pilocarpine has been researched along with Autosomal Dominant Juvenile Parkinson Disease in 6 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tremulous jaw movements were used as a model of parkinsonian tremor in these studies, and the effects of tropicamide were compared with those of the nonselective muscarinic antagonist atropine." | 7.74 | The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. ( Betz, AJ; Burgos, M; McLaughlin, PJ; Salamone, JD; Weber, SM, 2007) |
| "Safinamide is an α-aminoamide derivative that is currently in Phase III clinical trial development as an add-on therapy to levodopa or dopamine agonists for patients with Parkinson's disease." | 5.39 | Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor. ( Collins-Praino, LE; Lobianco, C; Podurgiel, S; Randall, PA; Roach, A; Salamone, JD; Yohn, S, 2013) |
| " Here, using a model for parkisonian tremor, the pilocarpine-induced tremulous jaw movements (TJMs), we show that the deletion of GPR37 attenuated the TJMs in response to this cholinomimetic." | 3.81 | Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent. ( Ciruela, F; Fernández-Dueñas, V; Gandía, J; Morató, X; Stagljar, I, 2015) |
| "Tremulous jaw movements were used as a model of parkinsonian tremor in these studies, and the effects of tropicamide were compared with those of the nonselective muscarinic antagonist atropine." | 3.74 | The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. ( Betz, AJ; Burgos, M; McLaughlin, PJ; Salamone, JD; Weber, SM, 2007) |
| "Safinamide is an α-aminoamide derivative that is currently in Phase III clinical trial development as an add-on therapy to levodopa or dopamine agonists for patients with Parkinson's disease." | 1.39 | Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor. ( Collins-Praino, LE; Lobianco, C; Podurgiel, S; Randall, PA; Roach, A; Salamone, JD; Yohn, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yasuda, K | 1 |
| Abe, H | 1 |
| Koganemaru, G | 1 |
| Ikeda, T | 1 |
| Arimori, K | 1 |
| Ishida, Y | 1 |
| Gandía, J | 1 |
| Morató, X | 1 |
| Stagljar, I | 1 |
| Fernández-Dueñas, V | 1 |
| Ciruela, F | 1 |
| Podurgiel, S | 1 |
| Collins-Praino, LE | 1 |
| Yohn, S | 1 |
| Randall, PA | 1 |
| Roach, A | 1 |
| Lobianco, C | 1 |
| Salamone, JD | 3 |
| FEINBERG, I | 1 |
| KORESKO, RL | 1 |
| HELLER, N | 1 |
| STEINBERG, HR | 1 |
| Betz, AJ | 1 |
| McLaughlin, PJ | 1 |
| Burgos, M | 1 |
| Weber, SM | 1 |
| Correa, M | 1 |
| Carlson, BB | 1 |
| Wisniecki, A | 1 |
| Mayorga, AJ | 1 |
| Nisenbaum, E | 1 |
| Nisenbaum, L | 1 |
| Felder, C | 1 |
1 review available for pilocarpine and Autosomal Dominant Juvenile Parkinson Disease
| Article | Year |
|---|---|
Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism.
Topics: Acetylcholine; Animals; Humans; Jaw; Mice; Mice, Knockout; Motor Activity; Muscarinic Agonists; Musc | 2001 |
5 other studies available for pilocarpine and Autosomal Dominant Juvenile Parkinson Disease
| Article | Year |
|---|---|
Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum.
Topics: Animals; Antiparkinson Agents; Apomorphine; Benzothiazoles; Disease Models, Animal; Infusions, Intra | 2015 |
Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.
Topics: Adenosine A2 Receptor Antagonists; Animals; Jaw; Male; Mice, Inbred C57BL; Mice, Knockout; Movement; | 2015 |
Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor.
Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Dopamine Agonists; Locomotion; Male; Muscarini | 2013 |
UNUSUALLY HIGH DREAM TIME IN A HALLUCINATING PATIENT.
Topics: Dreams; Drug Therapy; Electroencephalography; Eye Movements; Geriatrics; Hallucinations; Humans; Par | 1965 |
The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors.
Topics: Animals; Atropine; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; J | 2007 |