pilocarpine has been researched along with Aura in 521 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pilocarpine-induced (PILO) model has helped elucidate the electrophysiological and molecular aspects related to mesial temporal lobe epilepsy." | 8.31 | Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival. ( Athié, MCP; Cavalheiro, EA; Cendes, F; Conte, FF; Covolan, L; Gilioli, R; Lopes-Cendes, I; Malheiros, JM; Marchesini, RB; Matos, AHB; Pascoal, LB; Pascoal, VDB; Pereira, TC; Polli, RS; Secolin, R; Tannús, A; Vieira, AS, 2023) |
| "The present study aims to formulate and evaluate the efficacy of chrysin-loaded nanoemulsion (CH NE) against lithium/pilocarpine-induced epilepsy in rats, as well as, elucidate its effect on main epilepsy pathogenesis cornerstones; neuronal hyperactivity, oxidative stress, and neuroinflammation." | 8.31 | Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway. ( Ahmed, N; Ahmed, Y; Alshafei, H; Alshafei, R; Ashraf, N; El-Derany, MO; Ezz, S; George, MY; Ibrahim, C; Ibrahim, SS; Khaled, G; Khaled, H; Saleh, A; Waleed, H; Zaher, M, 2023) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 8.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| "The present study was undertaken to investigate the efficacy of a characterized hydroalcoholic extract (NJET) of Nardostachys jatamansi in the lithium-pilocarpine rat model of spontaneous recurrent seizures (SRS) and associated cardiac irregularities." | 8.31 | Protective effect of Nardostachys jatamansi extract against lithium-pilocarpine-induced spontaneous recurrent seizures and associated cardiac irregularities in a rat model. ( Patial, V; Rahmatkar, SN; Rana, AK; Sharma, S; Singh, D, 2023) |
| "A common way to investigate epilepsy and the effect of antiepileptic pharmaceuticals is to analyze the movement patterns of zebrafish larvae treated with different convulsants like pentylenetetrazol (PTZ), pilocarpine, etc." | 8.31 | A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae. ( Aly, N; Budan, F; Dittrich, B; Gorbe, A; Jin, M; Sik, A; Szentpeteri, JL; Szep, D, 2023) |
| " A single, systemic dose of mefloquine administered early after pilocarpine-induced status epilepticus (SE) in rat reduced both development of SRS and behavioral co-morbidities." | 8.31 | Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus. ( Santhakumar, V; Shao, M; Yu, H; Yu, J, 2023) |
| " This study aimed to analyze the changes in gene expression of mGluR subtypes (1-5, 7, 8) in various rat brain regions in the latent and chronic phases of a lithium-pilocarpine model of epilepsy." | 8.12 | Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy. ( Dyomina, AV; Kovalenko, AA; Schwarz, AP; Zaitsev, AV; Zakharova, MV; Zubareva, OE, 2022) |
| "Based on the pilocarpine hydrochloride-induced rat model of epilepsy, cortical-striatum brain slices of rats were examined based on field excitatory post-synaptic potentials." | 8.12 | Cu-Zn SOD suppresses epilepsy in pilocarpine-treated rats and alters SCN2A/Nrf2/HO-1 expression ( Tan, ZG; Wen, F; Xiang, J, 2022) |
| "Morphine is widely used in patients and has been reported to alter seizure threshold, but its role in the development of epilepsy is unknown." | 8.12 | Effect of morphine administration after status epilepticus on epileptogenesis in rats. ( Gupta, YK; Joshi, D; Katyal, J; Kumar, H, 2022) |
| " The objective of the current study was to investigate the effects of endurance training, applied before and after pilocarpine (Pilo) administration, on status epilepticus (SE) severity, and its relation to epileptogenesis deleterious consequences during the chronic epileptic phase." | 8.12 | Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. ( Atanasova, M; Georgieva, K; Ioanidu, L; Nenchovska, Z; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "We investigated the correlations among cognitive impairment, MFS, seizure frequency and drug resistance in a rat model of epilepsy induced by lithium-pilocarpine." | 8.02 | Cognitive Impairment and Mossy Fiber Sprouting in a Rat Model of Drug-resistant Epilepsy Induced by Lithium-pilocarpine. ( Huang, Y; Li, Y; Luo, X; Ren, S; Wang, L; Wu, G; Wu, J; Wu, Q, 2021) |
| "Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures." | 8.02 | Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network. ( Dabirmanesh, B; Fathollahi, Y; Khajeh, K; Khorsand, B; Mirnajafi-Zadeh, J; Rizvanov, AA; Sadeghi, L; Salafutdinov, II; Sayyah, M; Shojaei, A; Zahiri, J, 2021) |
| "We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test." | 8.02 | Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test. ( Bocca Nejm, M; Cysneiros, RM; Finsterer, J; Guimarães-Marques, MJ; Scorza, CA; Scorza, FA; Victorino, DB, 2021) |
| " In the present study, the effects of CCR2 antagonist was investigated using the pilocarpine rat model of epilepsy." | 7.96 | Treatment with CCR2 antagonist is neuroprotective but does not alter epileptogenesis in the pilocarpine rat model of epilepsy. ( Arisi, GM; Campbell, JJ; Foresti, ML; Mello, LE, 2020) |
| "We investigated the coronary arteries reactivity alterations in rats with epilepsy induced by pilocarpine." | 7.91 | Coronary vasodilation impairment in pilocarpine model of epilepsy. ( Colugnati, DB; da Silva, M; de Castro, CH; Dos Santos, FCA; Ghazale, PP; Gomes, KP; Mendes, EP; Pansani, AP; Scorza, FA; Vitorino, PR, 2019) |
| " Next, we tested an intravenous preparation of CBD (10 mg/kg single dose) in a rat model of pilocarpine-induced status epilepticus." | 7.91 | Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. ( Barker-Haliski, M; Bazelot, M; Glyn, S; Jones, N; McNeish, AJ; Patra, PH; Sandhu, H; Whalley, BJ; White, HS; Williams, CM, 2019) |
| " We examined the impact of early minor activation of TLR4 and TLR2 on the severity of seizure in the pilocarpine rat model of temporal lobe epilepsy (TLE)." | 7.91 | Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy. ( Daftari, M; Hosseinzadeh, M; Khodagholi, F; Motamedi, F; Naderi, N; Pourbadie, HG, 2019) |
| " We evaluated the neuroprotective effects of AA1R on hippocampal neuronal injury after lithium chloride-pilocarpine-induced epilepsy in rats." | 7.91 | ADENOSINE A1 RECEPTOR AGONIST PROTECTS AGAINST HIPPOCAMPAL NEURONAL INJURY AFTER LITHIUM CHLORIDE-PILOCARPINE-INDUCED EPILEPSY. ( Cui, G; Ji, H; Kong, L; Liu, Y; Tang, H; Xiao, Q, 2019) |
| " Accordingly, in the present study, we sought to explore whether TRPV4 is involved in the regulation of Cx expression following pilocarpine-induced status epilepticus (PISE) in mice." | 7.91 | Transient receptor potential vanilloid 4 is involved in the upregulation of connexin expression following pilocarpine-induced status epilepticus in mice. ( An, D; Chen, L; Men, C; Qi, M; Wang, Z; Xu, W; Zhan, Y; Zhou, L, 2019) |
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 7.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| " This study aimed to investigate the role of mitochondrial Rho (Miro) 1 in epilepsy, using a mouse model of pilocarpine-induced status epilepticus (SE)." | 7.88 | Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy. ( Lian, Y; Xie, N; Zhang, H; Zheng, Y, 2018) |
| " In the present study in the mouse pilocarpine model of temporal lobe epilepsy, we investigated the alterations of alpha 1 subunits of L-type VDCC in the CA3 area of the hippocampus at different stages of epileptogenesis, i." | 7.88 | Alterations of L-type voltage dependent calcium channel alpha 1 subunit in the hippocampal CA3 region during and after pilocarpine-induced epilepsy. ( Tang, FR; Wang, H; Xu, JH; Zhang, W, 2018) |
| "Initially, hippocampal slices were obtained from sham rats and rats subjected to the Li-pilocarpine model of epilepsy, at 1, 14, and 56 days after status epilepticus (SE), which correspond to the acute, silent, and chronic phases." | 7.88 | Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis. ( de Oliveira, DL; Gonçalves, CA; Hansen, F; Leite, MC; Negri, E; Vizuete, AFK, 2018) |
| " Therefore, the aim of this study was to verify the role of long-term treatment with vitamin E in rats submitted to the pilocarpine model of epilepsy." | 7.88 | Long-term monotherapy treatment with vitamin E reduces oxidative stress, but not seizure frequency in rats submitted to the pilocarpine model of epilepsy. ( Colugnati, DB; Cysneiros, RM; de Lima, E; Ferrari, D; Ghazale, PP; Janjoppi, L; Pansani, AP; Scorza, FA; Sinigaglia-Coimbra, R, 2018) |
| "We studied early alterations in the GABAergic system of the rat hippocampus in the lithium-pilocarpine model of epilepsy." | 7.85 | Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy. ( Karyakin, VB; Magazanik, LG; Vasil'ev, DS; Zaitsev, AV; Zhuravin, IA, 2017) |
| "The present results indicate that tangeretin exerted potent neuroprotective effects against pilocarpine-induced seizures via the activation of PI3K/Akt signaling and the regulation of MMPs." | 7.85 | Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway. ( Cao, YL; Guo, XQ; Hao, F; Liu, XW; Wang, ML; Yan, ZR, 2017) |
| " We examined the protein expression levels of hippocampal Cx36 (the prominent Cx present between GABAergic interneurons) and Cx43 (the main Cx expressed by astrocytes) during epileptogenesis in the pilocarpine model of epilepsy." | 7.85 | Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy. ( Babapour, V; Mahdian, R; Motaghi, S; Sayyah, M, 2017) |
| " We performed long-term video-EEG monitoring of 16 epileptic rats after pilocarpine-induced status epilepticus and five control animals." | 7.83 | Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats. ( Bajorat, R; Brenndörfer, L; Goerss, D; Kirschstein, T; Köhling, R; Schwabe, L, 2016) |
| " A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration." | 7.83 | Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| " The main objective of this work was to investigate the effect of the selective 5-HT selective reuptake inhibitor (SSRI) fluoxetine administered subacutely (10mg/kg/day×7 days) on the eventual metabolic impairment induced by the lithium-pilocarpine model of epilepsy in rats." | 7.81 | Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2015) |
| "TO determine neuroprotective properties of levetiracetam and simvastatin using rats with pilocaroine-induced epilepsy." | 7.81 | [Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models]. ( Chen, T; Li, MQ; Liu, L; Zhang, WW, 2015) |
| "Triheptanoin, the triglyceride of heptanoate, is anticonvulsant in various epilepsy models." | 7.80 | Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy. ( Borges, K; Hadera, MG; McDonald, TS; Smeland, OB; Sonnewald, U; Tan, KN, 2014) |
| "In vivo mGluR5 images were acquired using [11C]ABP688 microPET/CT in pilocarpine-induced chronic epilepsy rat models and controls." | 7.80 | In vivo imaging of mGluR5 changes during epileptogenesis using [11C]ABP688 PET in pilocarpine-induced epilepsy rat model. ( Choi, H; Chung, JK; Hwang, DW; Im, HJ; Jeong, JM; Kang, H; Kim, EE; Kim, YK; Lee, B; Lee, DS; Lee, YS; Oh, SW, 2014) |
| "To explore the effects of neuronal Per-Arnt-Sim domain protein 4 (Npas4) on seizures in pilocarpine-induced epileptic rats, Npas4 expression was detected by double-label immunofluorescence, immunohistochemistry, and Western blotting in the brains of pilocarpine-induced epileptic model rats at 6 h, 24 h, 72 h, 7 d, 14 d, 30 d, and 60 d after status epilepticus." | 7.80 | The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats. ( Guo, J; Hu, R; Long, X; Ren, M; Shen, W; Wang, D; Wang, X; Yang, G; Zeng, K, 2014) |
| "To analyze the survival and the changes of proportions of Calbindin, Calretinin and Parvalbumin positive neurons in mouse hippocampal CA area at chronic stage of Pilocarpine-induced epilepsy." | 7.79 | [Survival of calbindin, calretinin and parvalbumin positive neurons in mouse hippocampal CA area at chronic stage of pilocarpine-induced epilepsy]. ( Liu, J; Liu, Y; Tang, F, 2013) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 7.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| " The pilocarpine model in rodents reproduces the main features of mesial temporal lobe epilepsy related to hippocampus sclerosis (MTLE-HS) in humans." | 7.78 | Time-dependent modulation of mitogen activated protein kinases and AKT in rat hippocampus and cortex in the pilocarpine model of epilepsy. ( de Cordova, FM; de Mello, N; Leal, RB; Lopes, MW; Nunes, JC; Soares, FM; Walz, R, 2012) |
| " The present study aimed to test the feasibility of using manganese-enhanced magnetic resonance imaging (MEMRI) to detect MFS in the chronic phase of the well-established pilocarpine (Pilo) rat model of temporal lobe epilepsy (TLE)." | 7.78 | Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy. ( Covolan, L; Longo, BM; Malheiros, JM; Mello, LE; Paiva, FF; Polli, RS; Silva, AC; Tannús, A, 2012) |
| "The effects of ALAC administered per os were evaluated by standard protocols against audiogenic seizures in Genetic Epilepsy Prone Rats (GEPR-9 rats), maximal electroshock (MES)-induced seizures in rats, pilocarpine-induced seizures in mice, spontaneous chronic seizures in mice exposed to pilocarpine-induced status epilepticus (SE), and absence seizures in WAG/Rij rats." | 7.77 | Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy. ( Citraro, R; De Fazio, S; De Sarro, G; Mainardi, P; Perucca, E; Raggio, R; Russo, E; Scicchitano, F, 2011) |
| "The present paper is the first work to determine the effect of lipopolysaccharide (LPS) in the pilocarpine model of epilepsy on the morphology of rat hippocampal astrocytes in vivo." | 7.77 | Investigations of hippocampal astrocytes in lipopolysaccharide-preconditioned rats in the pilocarpine model of epilepsy. ( Cybulska, R; Dmowska, M; Jaworska-Adamu, J; Krawczyk, A; Pawlikowska-Pawlęga, B, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 7.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| "Status epilepticus was induced in the rats by administration of pilocarpine 350 mg/kg i." | 7.77 | Piperine protects epilepsy associated depression: a study on role of monoamines. ( Nayak, S; Pal, A; Sahu, PK; Swain, T, 2011) |
| "Chronic epilepsy was elicited after status epilepticus (SE) induced by lithium-pilocarpine in adult Wistar rats." | 7.76 | Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine. ( Guo, Y; Jiang, L, 2010) |
| " We induced status epilepticus (SE) with pilocarpine in adult rats, and investigated endothelial cell proliferation (BrdU and rat endothelial cell antigen-1 (RECA-1) double-labeling), vessel length (unbiased stereology), thrombocyte aggregation (thrombocyte immunostaining), neurodegeneration (Nissl staining), neurogenesis (doublecortin (DCX) immunohistochemistry), and mossy fiber sprouting (Timm staining) in the hippocampus at different time points post-SE." | 7.76 | Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. ( Gröhn, O; Hayward, N; Ndode-Ekane, XE; Pitkänen, A, 2010) |
| " Pilocarpine was administered to induce status epilepticus." | 7.76 | Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus. ( Choy, M; Gadian, DG; Lythgoe, MF; Scott, RC; Thomas, DL; Wells, JA, 2010) |
| "To analyze cellular mechanisms of limbic-seizure suppression, the response to pilocarpine-induced seizures was investigated in cortex and thalamus, comparing epilepsy-resistant rats Proechimys guyannensis with Wistar rats." | 7.75 | Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Spreafico, R, 2009) |
| "The lithium-pilocarpine model of epilepsy in rat has been used extensively to investigate basic mechanisms of epilepsy and mimics human temporal lobe epilepsy." | 7.75 | Longitudinal microPET imaging of brain glucose metabolism in rat lithium-pilocarpine model of epilepsy. ( Dupont, P; Goffin, K; Van Laere, K; Van Paesschen, W, 2009) |
| "To investigate whether anterior thalamic nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy." | 7.75 | Bilateral anterior thalamic nucleus lesions are not protective against seizures in chronic pilocarpine epileptic rats. ( Ballester, G; Bonilha, SM; Covolan, L; Ewerton, FI; Fantin Cavarsan, C; Hamani, C; Lozano, AM; Marcolin de Almeida, F; Mello, LE, 2009) |
| " To determine if a single event of status epilepticus and its latent consequences can affect motor map expression, we assessed forelimb motor maps in rats using the pilocarpine model of temporal lobe epilepsy." | 7.75 | Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain. ( Flynn, C; Ozen, LJ; Teskey, GC; Vuong, J; Young, NA, 2009) |
| " Using the epilepsy model obtained by systemic administration of pilocarpine in rats, we investigated the lipid peroxidation, nitrite content, superoxide dismutase (SOD) and catalase activities in the hippocampus of rats during chronic period." | 7.75 | Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine. ( Freitas, RM, 2009) |
| " In this study, we aimed to investigate the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus (PISE) and their relationship with epileptogenesis." | 7.74 | Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE). ( Chen, S; Chen, Z; Li, X; Zhou, J; Zhou, L; Zhu, F, 2008) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 7.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| "Recently we reported that astroglial loss and subsequent gliogenesis in the dentate gyrus play a role in epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 7.74 | Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus. ( Choi, KC; Choi, SY; Kang, TC; Kim, DS; Kim, DW; Kim, JE; Kwak, SE; Kwon, OS, 2008) |
| "Ecto-nucleotidases, one of the main mechanisms involved in the control of adenosine levels in the synaptic cleft, have shown increased activities after the pilocarpine model of epilepsy." | 7.74 | Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. ( Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ, 2007) |
| " Our study showed that there was an increased CD40 expression on activated microglia in the brain injury after lithium pilocarpine-induced status epilepticus (SE) in rats." | 7.74 | Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. ( Deng, Y; Huang, Y; Li, R; Li, Y; Sun, H; Yang, J; Yu, X; Zhao, G, 2008) |
| "Kainic acid was administered in repeated low doses (5 mg/kg) every hour until each Sprague-Dawley rat experienced convulsive status epilepticus for >3 h." | 7.73 | Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy. ( Chapman, PL; Dudek, FE; Ferraro, DJ; Grabenstatter, HL; Williams, PA, 2005) |
| " We studied the nestin distribution in the hippocampal formation of rats submitted to pilocarpine model of epilepsy." | 7.73 | Expression of nestin in the hippocampal formation of rats submitted to the pilocarpine model of epilepsy. ( Arida, RM; Cavalheiro, EA; Naffah-Mazzacoratti, MG; Scorza, CA; Scorza, FA, 2005) |
| " In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2h during pilocarpine induced status epilepticus, and never recovered." | 7.73 | Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. ( Burgunder, JM; Chang, ML; Chia, SC; Ma, DL; Probst, A; Tang, FR; Tang, YC, 2006) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 7.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| " Most animals present seizures at rest rather than during exercise and LCMRglu was measured during the interictal phase of the chronic period of a pilocarpine model of epilepsy by the [14C]2-deoxyglucose (2DG) method." | 7.72 | Physical training does not influence interictal LCMRglu in pilocarpine-treated rats with epilepsy. ( Arida, RM; Cavalheiro, EA; Fernandes, MJ; Preti, SC; Scorza, FA, 2003) |
| " In order to test whether the revealed abnormalities give rise to increased susceptibility to seizures in TN-R-deficient mice, we used the pilocarpine model of epilepsy." | 7.72 | Mice deficient for the extracellular matrix glycoprotein tenascin-r show physiological and structural hallmarks of increased hippocampal excitability, but no increased susceptibility to seizures in the pilocarpine model of epilepsy. ( Brenneke, F; Bukalo, O; Dityatev, A; Lie, AA, 2004) |
| "At 4 h during pilocarpine-induced status epilepticus (DPISE) in rat, protein kinase C (PKC)beta1, PKCbeta2, and PKCgamma were induced at the border between the stratum oriens and alveus (O/A border) of CA1 in the hippocampus." | 7.72 | Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus. ( Chen, Y; Chia, SC; Gao, H; Lee, WL; Loh, YT; Tang, FR, 2004) |
| " Here, we examine two neuroprotective agents, the noncompetitive NMDA antagonist ketamine and the dopaminergic antagonist acepromazine, for their efficacy in attenuating cognitive impairments in the lithium-pilocarpine (LI-PILO) model of rat limbic epilepsy." | 7.72 | Normal spatial and contextual learning for ketamine-treated rats in the pilocarpine epilepsy model. ( McKay, BE; Persinger, MA, 2004) |
| "Thirty days after the induction of seizures in 16 rats with lithium (3 mEq/kg) and pilocarpine (30 mg/kg), the numbers of episodes of motor seizures (rapid forelimb clonus) during daily 10-minute observational periods were recorded for 11 months." | 7.72 | Emergence of spontaneous seizures during the year following lithium/pilocarpine-induced epilepsy and neuronal loss within the right temporal cortices. ( Dupont, MJ; Persinger, MA, 2004) |
| " Neural activation was studied in the Proechimys hippocampus, using Fos induction, within 24 h after pilocarpine-induced seizures; neurodegenerative events were investigated in parallel, using FluoroJade B histochemistry." | 7.72 | Fos induction and persistence, neurodegeneration, and interneuron activation in the hippocampus of epilepsy-resistant versus epilepsy-prone rats after pilocarpine-induced seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Priel, MR, 2004) |
| "We studied the effects of TPM on mitochondrial function in the pilocarpine rat model of chronic epilepsy and in isolated mitochondria from rat brain." | 7.72 | The mechanism of neuroprotection by topiramate in an animal model of epilepsy. ( Debska-Vielhaber, G; Elger, CE; Kudin, AP; Kunz, WS; Vielhaber, S, 2004) |
| "This study addresses the question of epileptogenesis by investigating the effects of carbamazepine (CBZ) on the silent period of the pilocarpine model of epilepsy." | 7.71 | Effect on epileptogenesis of carbamazepine treatment during the silent period of the pilocarpine model of epilepsy. ( Capella, HM; Lemos, T, 2002) |
| "Fluoxetine (20 mg/kg) and TFMPP (5 mg/kg) were administered to rats with pilocarpine-induced epilepsy." | 7.71 | Effects of fluoxetine and TFMPP on spontaneous seizures in rats with pilocarpine-induced epilepsy. ( Dudek, FE; Hernandez, EJ; Williams, PA, 2002) |
| "The aim of the study was to detect by texture analysis non easily visible anomalies of magnetic resonance (MR) images of piriform and entorhinal cortices relevant to the lithium-pilocarpine (Li-Pilo) model of temporal lobe epilepsy in rats." | 7.71 | Detection of late epilepsy by the texture analysis of MR brain images in the lithium-pilocarpine rat model. ( Chambron, J; Mauss, Y; Namer, IJ; Roch, C; Yu, O, 2002) |
| "At variance with pilocarpine-induced epilepsy in the laboratory rat, pilocarpine administration to the tropical rodent Proechimys guyannensis (casiragua) elicited an acute seizure that did not develop in long-lasting status epilepticus and was not followed by spontaneous seizures up to 30 days, when the hippocampus was investigated in treated and control animals." | 7.71 | The spiny rat Proechimys guyannensis as model of resistance to epilepsy: chemical characterization of hippocampal cell populations and pilocarpine-induced changes. ( Bentivoglio, M; Carvalho, RA; Cavalheiro, EA; Correia, L; Fabene, PF, 2001) |
| " Here we have decided to investigate the participation of the GABAergic system of the zona incerta, one of its major neurotransmitters with widespread projections to the neocortex, in the pilocarpine (Pilo) model of epilepsy." | 7.71 | Inhibitory role of the zona incerta in the pilocarpine model of epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Hamani, C; Mello, LE; Sakabe, S, 2002) |
| "Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both." | 7.70 | Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: a qualitative study. ( Calderazzo, L; Cavalheiro, EA; Sanabria, ER; Scorza, FA, 1998) |
| "Systemic administration of pilocarpine, which results in status epilepticus followed by recurrent seizures in rats, is a widely used experimental model of chronic limbic epilepsy." | 7.70 | Persistence and atrophy of septal/diagonal band neurons expressing the p75 neurotrophin receptor in pilocarpine-induced chronic epilepsy in the rat. ( Amado, D; Bentivoglio, M; Cavalheiro, EA; Correia, L, 1998) |
| " Pilocarpine-treated rats present status epilepticus, which is followed by a seizure-free period (silent), by a period of spontaneous recurrent seizures (chronic), and the hippocampus of these animals exhibits cell loss and mossy fiber sprouting." | 7.70 | Selective alterations of glycosaminoglycans synthesis and proteoglycan expression in rat cortex and hippocampus in pilocarpine-induced epilepsy. ( Amado, D; Argañaraz, GA; Bellissimo, MI; Cavalheiro, EA; Nader, HB; Naffah-Mazzacoratti, MG; Porcionatto, MA; Scorza, FA; Silva, R, 1999) |
| "Pilocarpine (PILO) administered to rats acutely induces status epilepticus (acute period), which is followed by a transient seizure-free period (silent period), and finally by a chronic phase of spontaneous recurrent seizures (chronic period, SRS) that lasts for the rest of animal's life." | 7.69 | Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. ( Bellíssimo, MI; Cavalheiro, EA; Naffah-Mazzacoratti, MG, 1995) |
| "Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice." | 7.69 | The pilocarpine model of epilepsy in mice. ( Cavalheiro, EA; Priel, MR; Santos, NF, 1996) |
| " To study the age-related susceptibility to the development of chronic epilepsy we used the pilocarpine model of epilepsy (PME)." | 7.69 | Developmental aspects of the pilocarpine model of epilepsy. ( Cavalheiro, EA; dos Santos, NF; Priel, MR, 1996) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 7.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "Berberine hydrochloride is a plant alkaloid with versatile medicinal applications, yet it has suffered from multiple limitations in its usage." | 5.91 | Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy. ( Aly, RG; El-Kamel, AH; El-Nahas, AE; Elbedaiwy, HM; Helmy, MW; Masoud, IM, 2023) |
| "Epilepsy is one of the most common neurologic diseases, and around 30% of all epilepsies, particularly the temporal lobe epilepsy (TLE), are highly refractory to current pharmacological treatments." | 5.91 | A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes. ( Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á, 2023) |
| "Icariin has been identified that it could cross the blood-brain barrier and enter the hippocampus to exhibit therapeutic effects." | 5.91 | Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy. ( Feng, L; Liu, Y; Wang, J; Wu, Y; Yan, L; Yang, K, 2023) |
| "Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear." | 5.72 | MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy. ( Antonova, IV; Dyomina, AV; Griflyuk, AV; Kovalenko, AA; Postnikova, TY; Smolensky, IV; Zaitsev, AV; Zakharova, MV, 2022) |
| "Epilepsy is one of the most common neurological disorders affecting most social, economic and biological aspects of human life." | 5.72 | Treatment of pilocarpine-induced epileptic seizures in adult male mice. ( Abdelbasset, WK; Huldani, H; Jalil, AT; Jasim, SA; Margiana, R; Mohammad, HJ; Ridha, HS; Rudiansyah, M; Yasin, G, 2022) |
| "Demyelination is observed in animal models of intractable epilepsy (IE)." | 5.62 | Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study. ( Chen, Z; Gu, J; Ma, K; Niu, J; Tao, S; Wang, P; Wang, S; Wei, S; Yang, L; Ye, M; Zhang, G; Zhang, L, 2021) |
| "Gastrodin has shown the potential as an anticonvulsant." | 5.62 | Gastrodin attenuates lithium-pilocarpine-induced epilepsy by activating AMPK-mediated PPARα in a juvenile rat model. ( Han, J; Li, Y; Wang, Y; Yang, Y, 2021) |
| "Epilepsy is one of the most frequent neurological disorders characterized by an enduring predisposition to generate epileptic seizures." | 5.62 | Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy. ( Al-Rafiah, AR; Mehdar, KM, 2021) |
| "Baicalein has multiple effects, including anti-inflammatory action." | 5.56 | Baicalein Ameliorates Epilepsy Symptoms in a Pilocarpine-Induced Rat Model by Regulation of IGF1R. ( Du, Z; Fu, P; Hu, J; Li, Z; Lv, K; Sun, Y; Wu, X; Yu, J; Yuan, Q, 2020) |
| "Kynurenic acid is an endogenous modulator of ionotropic glutamate receptors and a suppressor of the immune system." | 5.56 | Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104. ( Dulka, K; Földesi, I; Fülöp, F; Gulya, K; Kata, D; Lajkó, N; Mátyás, A; Mihály, A; Szabó, M; Vécsei, L, 2020) |
| "Neurotrophic factors are candidates for treating epilepsy, but their development has been hampered by difficulties in achieving stable and targeted delivery of efficacious concentrations within the desired brain region." | 5.51 | Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy. ( Barbieri, M; Bell, WJ; Emerich, DF; Falcicchia, C; Fradet, T; Kokaia, M; Lovisari, F; Paolone, G; Simonato, M; Wahlberg, LU, 2019) |
| "Aucubin (AU) is an iridoid glycoside derived from Eucommia ulmoides that possesses anti-inflammatory and neuroprotective effects." | 5.51 | Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission. ( Chen, L; Chen, S; Hu, K; Huang, Q; Huang, X; Li, C; Ouyang, DS; Wang, X; Zeng, G; Zeng, X; Zhou, L; Zong, W, 2019) |
| "Epilepsy is associated with increased morbidity and mortality together and places a large financial burden on individuals and society." | 5.48 | Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy. ( Chen, Y; Fajol, A; Ren, B; Shi, S; Song, S, 2018) |
| " The aim of the study was to conduct an in vivo evaluation of the relationship between treatments with synthetic cannabinoid arachidonyl-2'-chloroethylamide (ACEA) alone or in combination with valproic acid (VPA) and hippocampal neurogenesis in a mouse pilocarpine model of epilepsy." | 5.46 | A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy. ( Andres-Mach, M; Dudra-Jastrzębska, M; Haratym, J; Haratym-Maj, A; Maj, M; Rola, R; Zagaja, M; Łuszczki, JJ, 2017) |
| "Epilepsy affects 60 million people worldwide." | 5.46 | Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice. ( Benninger, F; Griffioen, K; Gross, A; Illouz, T; Madar, R; Offen, D; Okun, E; Steiner, I, 2017) |
| "No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups." | 5.43 | N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "EEG documented seizure activity and status epilepticus (SE) developed in 87." | 5.39 | Electrical stimulation of left anterior thalamic nucleus with high-frequency and low-intensity currents reduces the rate of pilocarpine-induced epilepsy in rats. ( Chang, FC; Jou, SB; Kao, IF; Yi, PL, 2013) |
| "In pilocarpine-treated mice, CCK was observed in dendritic spines and these were proportionally increased relative to controls, whereas the proportion of CCK-labeled terminals forming symmetric synapses was decreased." | 5.38 | Increased cholecystokinin labeling in the hippocampus of a mouse model of epilepsy maps to spines and glutamatergic terminals. ( Houser, CR; Wyeth, MS; Zhang, N, 2012) |
| "Epilepsy was induced by i." | 5.38 | Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. ( Aboul Ezz, HS; Faraag, AR; Khadrawy, YA; Noor, NA, 2012) |
| "Pilocarpine treatment significantly reduced the GAP-43 immunoreactivity in the inner molecular layer in both species, with some minor differences in the staining pattern." | 5.37 | Comparative immunohistochemistry of synaptic markers in the rodent hippocampus in pilocarpine epilepsy. ( Dobó, E; Károly, N; Mihály, A, 2011) |
| "Treatment with curcumin, NSO or valproate ameliorated most of the changes induced by pilocarpine and restored Na⁺, K⁺-ATPase activity in the hippocampus to control levels." | 5.37 | The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. ( Ezz, HS; Khadrawy, YA; Noor, NA, 2011) |
| "At the initiation of the seizure, (14)C-acetate uptake did not change significantly." | 5.36 | Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpine. ( Gee, A; Hosoi, R; Inoue, O; Kitano, D; Kuse, K; Momosaki, S, 2010) |
| "Status epilepticus is a clinical emergency that can lead to the development of acquired epilepsy following neuronal injury." | 5.36 | Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. ( Carter, DS; DeLorenzo, RJ; Deshpande, LS; Nagarkatti, N, 2010) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 5.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear." | 5.35 | Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009) |
| "Epilepsy is a syndrome of episodic brain dysfunction characterized by recurrent unpredictable, spontaneous seizures." | 5.35 | Down-regulation of cerebellar 5-HT(2C) receptors in pilocarpine-induced epilepsy in rats: therapeutic role of Bacopa monnieri extract. ( Abraham, PM; Krishnakumar, A; Paul, J; Paulose, CS, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 5.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| " For this study, we used the same pilocarpine ramping-up dosing protocol and behavioral test battery than in a previous study in NMRI mice, thus allowing direct comparison between these two mouse strains." | 5.35 | Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. ( Bankstahl, M; Gröticke, I; Löscher, W; Müller, CJ, 2009) |
| "Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality." | 5.35 | Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus. ( Bracey, JM; Churn, SB; Kurz, JE; Low, B, 2009) |
| "The course of untreated epilepsy is not well established." | 5.30 | The course of untreated seizures in the pilocarpine model of epilepsy. ( Arida, RM; Cavalheiro, EA; Peres, CA; Scorza, FA, 1999) |
| "Here we evaluated whether spontaneous seizures would lead to similar impairments." | 5.29 | Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures. ( Covolan, L; Mello, LE, 1996) |
| " A narrow bell-shaped dose-response relationship was found." | 5.28 | ACTH: a structure-activity study on pilocarpine-induced epilepsy. ( Croiset, G; De Wied, D, 1992) |
| " Motor limbic seizures induced by pilocarpine, 380 mg/kg intraperitoneally, are prevented by prior injection into the substantia nigra, pars reticulata, or the entopeduncular nucleus, of 2-APH, 10 nmol or 10 pmol, respectively." | 4.77 | Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. ( de Sarro, G; Meldrum, B; Millan, M; Patel, S, 1988) |
| "The pilocarpine-induced (PILO) model has helped elucidate the electrophysiological and molecular aspects related to mesial temporal lobe epilepsy." | 4.31 | Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival. ( Athié, MCP; Cavalheiro, EA; Cendes, F; Conte, FF; Covolan, L; Gilioli, R; Lopes-Cendes, I; Malheiros, JM; Marchesini, RB; Matos, AHB; Pascoal, LB; Pascoal, VDB; Pereira, TC; Polli, RS; Secolin, R; Tannús, A; Vieira, AS, 2023) |
| "The present study aims to formulate and evaluate the efficacy of chrysin-loaded nanoemulsion (CH NE) against lithium/pilocarpine-induced epilepsy in rats, as well as, elucidate its effect on main epilepsy pathogenesis cornerstones; neuronal hyperactivity, oxidative stress, and neuroinflammation." | 4.31 | Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway. ( Ahmed, N; Ahmed, Y; Alshafei, H; Alshafei, R; Ashraf, N; El-Derany, MO; Ezz, S; George, MY; Ibrahim, C; Ibrahim, SS; Khaled, G; Khaled, H; Saleh, A; Waleed, H; Zaher, M, 2023) |
| "9% saline, n = 5), the EP groups (lithium-pilocarpine was used to induce epilepsy, and tissues were harvested at 6 and 24 h, every time point, n = 5), the EP + Compound C group (the specific inhibitor of PGC-1α, 15 mg/kg in 2% DMSO, n = 5), and the EP + DMSO group (0." | 4.31 | PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats. ( Li, D; Liu, X; Luo, Z; Qiu, X; Tai, Z; Tuo, J; Wang, J; Xu, Z; Yang, J; Zhang, F; Zhang, H; Zhang, L, 2023) |
| "05) and STR (42%) and had no effect on pilocarpine-induced seizures." | 4.31 | Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity. ( Adassi, MB; Foutsop, AF; Kom, TD; Ngo Bum, E; Ngoupaye, GT; Yassi, FB, 2023) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 4.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| "The present study was undertaken to investigate the efficacy of a characterized hydroalcoholic extract (NJET) of Nardostachys jatamansi in the lithium-pilocarpine rat model of spontaneous recurrent seizures (SRS) and associated cardiac irregularities." | 4.31 | Protective effect of Nardostachys jatamansi extract against lithium-pilocarpine-induced spontaneous recurrent seizures and associated cardiac irregularities in a rat model. ( Patial, V; Rahmatkar, SN; Rana, AK; Sharma, S; Singh, D, 2023) |
| "Untreated lithium/pilocarpine SE induced a large increase in aggressive behavior, which involved all aspects of aggression in the resident-intruder paradigm when tested 3 months after SE." | 4.31 | Interictal aggression in rats with chronic seizures after an early life episode of status epilepticus. ( Baldwin, RA; Niquet, J; Suchomelova, L; Thompson, KW; Wasterlain, CG, 2023) |
| "A common way to investigate epilepsy and the effect of antiepileptic pharmaceuticals is to analyze the movement patterns of zebrafish larvae treated with different convulsants like pentylenetetrazol (PTZ), pilocarpine, etc." | 4.31 | A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae. ( Aly, N; Budan, F; Dittrich, B; Gorbe, A; Jin, M; Sik, A; Szentpeteri, JL; Szep, D, 2023) |
| " A single, systemic dose of mefloquine administered early after pilocarpine-induced status epilepticus (SE) in rat reduced both development of SRS and behavioral co-morbidities." | 4.31 | Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus. ( Santhakumar, V; Shao, M; Yu, H; Yu, J, 2023) |
| " This study aimed to analyze the changes in gene expression of mGluR subtypes (1-5, 7, 8) in various rat brain regions in the latent and chronic phases of a lithium-pilocarpine model of epilepsy." | 4.12 | Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy. ( Dyomina, AV; Kovalenko, AA; Schwarz, AP; Zaitsev, AV; Zakharova, MV; Zubareva, OE, 2022) |
| "This study aimed to evaluate the potential neuroprotective effects of ketogenic diet (KD) against the neuronal disruptions induced by SE in lithium-pilocarpine rat model of status epilepticus (SE)." | 4.12 | Ameliorating effect of ketogenic diet on acute status epilepticus: Insights into biochemical and histological changes in rat hippocampus. ( Abdelsamad, MA; Amin, HAA; Sadik, NAH; Shaheen, AA; Shehata, NI, 2022) |
| " In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy." | 4.12 | Dopamine depletion in wistar rats with epilepsy. ( Becker, EL; Biase, CLCL; Carvalho, EGA; Castro, DN; Cavalcante, JBN; Costa, AF; Costa, MV; Costa, PJMS; de Melo, MR; Félix, VB; Leão, SABF; Leite, ML; Lima, JA; Lino, ATS; Moura, IMFB; Mousinho, KC; Pai, JD; Quintella, GB; Saldanha-Filho, AJM; Santos, SDBD; Silva, ATMD; Silva, JCD; Tavares, MMA; Trindade-Filho, EM; Vieira, JSS; Zambrano, LI, 2022) |
| "Based on the pilocarpine hydrochloride-induced rat model of epilepsy, cortical-striatum brain slices of rats were examined based on field excitatory post-synaptic potentials." | 4.12 | Cu-Zn SOD suppresses epilepsy in pilocarpine-treated rats and alters SCN2A/Nrf2/HO-1 expression ( Tan, ZG; Wen, F; Xiang, J, 2022) |
| " In this study, we induced a generalized status epilepticus (SE) by systemic administration of lithium-pilocarpine to adult female rats." | 4.12 | Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain. ( Aripaka, SS; Bankstahl, JP; Bankstahl, M; Bascuñana, P; Mikkelsen, JD; Pazarlar, BA, 2022) |
| "Levetiracetam (LEV) suppresses the upregulation of proinflammatory molecules that occurs during epileptogenesis after status epilepticus (SE)." | 4.12 | Regulation of Inflammation-Related Genes through ( Hashimoto, R; Ishihara, Y; Itoh, K; Komori, R; Kono, T; Kozawa, C; Kubo, S; Matsuo, T; Yokota-Nakatsuma, A, 2022) |
| "Morphine is widely used in patients and has been reported to alter seizure threshold, but its role in the development of epilepsy is unknown." | 4.12 | Effect of morphine administration after status epilepticus on epileptogenesis in rats. ( Gupta, YK; Joshi, D; Katyal, J; Kumar, H, 2022) |
| " The objective of the current study was to investigate the effects of endurance training, applied before and after pilocarpine (Pilo) administration, on status epilepticus (SE) severity, and its relation to epileptogenesis deleterious consequences during the chronic epileptic phase." | 4.12 | Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. ( Atanasova, M; Georgieva, K; Ioanidu, L; Nenchovska, Z; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "We investigated the correlations among cognitive impairment, MFS, seizure frequency and drug resistance in a rat model of epilepsy induced by lithium-pilocarpine." | 4.02 | Cognitive Impairment and Mossy Fiber Sprouting in a Rat Model of Drug-resistant Epilepsy Induced by Lithium-pilocarpine. ( Huang, Y; Li, Y; Luo, X; Ren, S; Wang, L; Wu, G; Wu, J; Wu, Q, 2021) |
| " First, at the beginning of epileptic chronic phase, 30 days post-pilocarpine-induced Status Epilepticus (SE)." | 4.02 | In vitro Oscillation Patterns Throughout the Hippocampal Formation in a Rodent Model of Epilepsy. ( Calcagnotto, ME; Righes Marafiga, J; Vendramin Pasquetti, M, 2021) |
| " Pilocarpine epilepsy model mice with confirmed cluster pattern of spontaneous recurrent seizures by long-term video-electroencpehalography were sacrificed at the onset, peak, or end of a seizure cluster or in the seizure-free period." | 4.02 | Proteins related to ictogenesis and seizure clustering in chronic epilepsy. ( Chu, K; Han, D; Jeon, D; Jung, KH; Lee, SK; Lee, ST; Lee, WJ; Lim, JA; Moon, J; Park, DK; Park, KI; Yoo, JS, 2021) |
| "Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures." | 4.02 | Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network. ( Dabirmanesh, B; Fathollahi, Y; Khajeh, K; Khorsand, B; Mirnajafi-Zadeh, J; Rizvanov, AA; Sadeghi, L; Salafutdinov, II; Sayyah, M; Shojaei, A; Zahiri, J, 2021) |
| "We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test." | 4.02 | Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test. ( Bocca Nejm, M; Cysneiros, RM; Finsterer, J; Guimarães-Marques, MJ; Scorza, CA; Scorza, FA; Victorino, DB, 2021) |
| " Finally, we assessed PR regulation of epileptic seizures and status epilepticus (SE) induced by lithium-pilocarpine in female rats with the global deletion of PRs (PR knockout; PRKO) using video electroencephalography (-EEG)." | 4.02 | Limbic progesterone receptor activity enhances neuronal excitability and seizures. ( Batabyal, T; Joshi, S; Kapur, J; Labuz, A; Shiono, S; Sun, H; Williamson, J, 2021) |
| " In the present study, the effects of CCR2 antagonist was investigated using the pilocarpine rat model of epilepsy." | 3.96 | Treatment with CCR2 antagonist is neuroprotective but does not alter epileptogenesis in the pilocarpine rat model of epilepsy. ( Arisi, GM; Campbell, JJ; Foresti, ML; Mello, LE, 2020) |
| " We used the lithium-pilocarpine-induced epilepsy model in adolescent Sprague-Dawley rats in order to evaluate hippocampal neurogenesis and epileptogenesis following the onset of status epilepticus (SE)." | 3.96 | The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis. ( Chen, H; Chen, J; Cheng, L; Han, W; Jiang, L; Xie, L; Yuan, P, 2020) |
| "The present study tested whether ictal onset sites are regions of more severe interneuron loss in epileptic pilocarpine-treated rats, a model of human temporal lobe epilepsy." | 3.96 | Ictal onset sites and γ-aminobutyric acidergic neuron loss in epileptic pilocarpine-treated rats. ( Buckmaster, PS; Nagendran, M; Wyeth, M, 2020) |
| "The lithium-pilocarpine-induced epilepsy model was established in rats." | 3.96 | Chaihu-Longgu-Muli decoction relieves epileptic symptoms by improving autophagy in hippocampal neurons. ( Huang, HY; Li, F; Li, L; Lu, J; Qin, Y; Wang, Q; Xia, SS; Yang, P; Zhou, B; Zhu, Y, 2020) |
| " Similarly, we found that both focal and generalized seizures coexist in some pilocarpine-induced chronic temporal lobe epilepsy (TLE) rats." | 3.96 | Time-variant Epileptic Brain Functional Connectivity of Focal and Generalized Seizure in Chronic Temporal Lobe Epilepsy Rat ( Wang, Y; Xu, K; Yang, Y; Zhang, F; Zhu, J, 2020) |
| " Therefore, in the present study, SB203580 was used to inhibit the p38 MAPK signaling pathway in rats, and the expression levels of A1R and ENT1 in the brain tissue of rats with acute LiCl‑pilocarpine‑induced status epilepticus was detected." | 3.96 | Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1. ( Chen, Q; Chen, Y; Feng, Z; Huang, H; Peng, Y; Wang, J; Xu, Z; Zeng, J; Zhang, H; Zhang, J; Zhou, X, 2020) |
| " In the earlier work, 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine demonstrated anticonvulsant activity against pentylenetetrazole (PTZ)-induced seizures." | 3.96 | In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models. ( Askani, M; Malhi, SM; Nisar, U; Shaheen, F; Shahid, M; Simjee, SU, 2020) |
| "To observe the expressions of sphingosine kinase 1 (SphK1) and sphingosine-1-phosphate receptor 2 (S1PR2) in hippocampus of epileptic rats and to investigate the pathogenesis of SphK1 and S1PR2 in epilepsy." | 3.91 | [Altered expressions of SphK1 and S1PR2 in hippocampus of epileptic rats]. ( Chu, X; Cui, S; Dong, YY; Kong, QX; Wang, L, 2019) |
| "We investigated the coronary arteries reactivity alterations in rats with epilepsy induced by pilocarpine." | 3.91 | Coronary vasodilation impairment in pilocarpine model of epilepsy. ( Colugnati, DB; da Silva, M; de Castro, CH; Dos Santos, FCA; Ghazale, PP; Gomes, KP; Mendes, EP; Pansani, AP; Scorza, FA; Vitorino, PR, 2019) |
| " Next, we tested an intravenous preparation of CBD (10 mg/kg single dose) in a rat model of pilocarpine-induced status epilepticus." | 3.91 | Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. ( Barker-Haliski, M; Bazelot, M; Glyn, S; Jones, N; McNeish, AJ; Patra, PH; Sandhu, H; Whalley, BJ; White, HS; Williams, CM, 2019) |
| "A rat model of epilepsy was established using lithium chloride." | 3.91 | Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression. ( Dai, D; Fu, WL; Li, Y; Liu, J; Xu, XW; Yang, JZ; Zhu, HX, 2019) |
| " We examined the impact of early minor activation of TLR4 and TLR2 on the severity of seizure in the pilocarpine rat model of temporal lobe epilepsy (TLE)." | 3.91 | Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy. ( Daftari, M; Hosseinzadeh, M; Khodagholi, F; Motamedi, F; Naderi, N; Pourbadie, HG, 2019) |
| " We evaluated the neuroprotective effects of AA1R on hippocampal neuronal injury after lithium chloride-pilocarpine-induced epilepsy in rats." | 3.91 | ADENOSINE A1 RECEPTOR AGONIST PROTECTS AGAINST HIPPOCAMPAL NEURONAL INJURY AFTER LITHIUM CHLORIDE-PILOCARPINE-INDUCED EPILEPSY. ( Cui, G; Ji, H; Kong, L; Liu, Y; Tang, H; Xiao, Q, 2019) |
| " Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy." | 3.91 | The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019) |
| " Accordingly, in the present study, we sought to explore whether TRPV4 is involved in the regulation of Cx expression following pilocarpine-induced status epilepticus (PISE) in mice." | 3.91 | Transient receptor potential vanilloid 4 is involved in the upregulation of connexin expression following pilocarpine-induced status epilepticus in mice. ( An, D; Chen, L; Men, C; Qi, M; Wang, Z; Xu, W; Zhan, Y; Zhou, L, 2019) |
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 3.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| "The present study was designed to understand the molecular changes and cardiac parameters during different phases of epileptogenesis in lithium-pilocarpine (Li-pilo) rat model of epilepsy." | 3.91 | Spontaneous Recurrent Seizures Mediated Cardiac Dysfunction via mTOR Pathway Upregulation: A Putative Target for SUDEP Management. ( Mazumder, AG; Patial, V; Rana, AK; Sharma, S; Singh, D, 2019) |
| " Poststatus epilepticus model of TLE induced by pilocarpine in rodents has enhanced the understanding of the processes leading to epilepsy and thus, of potential targets for antiepileptogenic therapies." | 3.88 | Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis. ( Canzian, JM; Duarte, MMMF; Duarte, T; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS, 2018) |
| " Although it has been reported that AM404, a metabolite of acetaminophen, has anticonvulsant effects in several animal seizure models, little is known about the relation between acetaminophen and seizures." | 3.88 | Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs. ( Araki, H; Aso, H; Suemaru, K; Tanaka, A; Watanabe, M; Yoshikawa, M, 2018) |
| " This study aimed to investigate the role of mitochondrial Rho (Miro) 1 in epilepsy, using a mouse model of pilocarpine-induced status epilepticus (SE)." | 3.88 | Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy. ( Lian, Y; Xie, N; Zhang, H; Zheng, Y, 2018) |
| " In the present study in the mouse pilocarpine model of temporal lobe epilepsy, we investigated the alterations of alpha 1 subunits of L-type VDCC in the CA3 area of the hippocampus at different stages of epileptogenesis, i." | 3.88 | Alterations of L-type voltage dependent calcium channel alpha 1 subunit in the hippocampal CA3 region during and after pilocarpine-induced epilepsy. ( Tang, FR; Wang, H; Xu, JH; Zhang, W, 2018) |
| " Considering the importance in developing therapeutic strategies to prevent or modify epileptogenesis, we aimed the present study to test the hypothesis that atorvastatin modifies seizure susceptibility of mice after status epilepticus (SE)." | 3.88 | Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis. ( Fighera, MR; Furian, AF; Oliveira, CV; Oliveira, MS; Royes, LFF; Zorzi, VN, 2018) |
| "Initially, hippocampal slices were obtained from sham rats and rats subjected to the Li-pilocarpine model of epilepsy, at 1, 14, and 56 days after status epilepticus (SE), which correspond to the acute, silent, and chronic phases." | 3.88 | Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis. ( de Oliveira, DL; Gonçalves, CA; Hansen, F; Leite, MC; Negri, E; Vizuete, AFK, 2018) |
| " Therefore, hippocampal Pol1 activity was examined in mouse models of epilepsy including kainic acid- and pilocarpine-induced status epilepticus (SE) as well as a single seizure in response to pentylenetetrazole (PTZ)." | 3.88 | RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy. ( Hetman, M; Kolikonda, M; Naik, SP; Parlato, R; Pietrzak, M; Slomnicki, LP; Smith, SC; Vashishta, A, 2018) |
| "To explore the role of cGKII in epilepsy, we investigated the expression of cGKII in patients with temporal lobe epilepsy (TLE) and in a pilocarpine-induced rat model and then performed behavioral, histological, and electrophysiological analyses by applying either a cGKII agonist or inhibitor in the hippocampus of the animal model." | 3.88 | Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1. ( Gu, J; Lin, P; Lin, Z; Lu, S; Luo, J; Ma, Y; Tian, X; Wang, W; Wang, X; Xiao, F; Xiong, Y; Xu, D; Yang, Q; Yang, Y; Zhang, Y, 2018) |
| "In this research, rat model of epilepsy was established by pilocarpine induction." | 3.88 | LncRNA UCA1 inhibits epilepsy and seizure-induced brain injury by regulating miR-495/Nrf2-ARE signal pathway. ( Fan, WF; Geng, JF; Geng, JJ; Liu, X; Liu, XZ; Zhao, HB, 2018) |
| "A recent report has found that glucose oxidation and the activity of pyruvate dehydrogenase (PDH) are reduced in the chronic stage of the pilocarpine mouse epilepsy model." | 3.88 | The effect of dichloroacetate in mouse models of epilepsy. ( Borges, K; Durie, D; McDonald, TS, 2018) |
| "We have used voltage clamp recordings in isolated dentate granule cells (DGCs) and cortical pyramidal neurons of control versus chronically epileptic rats (pilocarpine model of epilepsy) and in DGCs isolated from hippocampal specimens from temporal lobe epilepsy patients to examine S-Lic effects on sodium channel slow inactivation." | 3.88 | Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells. ( Beck, H; Hebeisen, S; Holtkamp, D; Opitz, T; Soares-da-Silva, P, 2018) |
| " We found that different doses of lithium affect epileptic seizure activity and bidirectionally modulate the susceptibility to and severity of seizures induced by pilocarpine in rats." | 3.88 | Lithium affects rat hippocampal electrophysiology and epileptic seizures in a dose dependent manner. ( Cao, X; Jiang, G; Li, Z; Pu, T; Wang, X; Yu, J; Zhang, X; Zhou, R, 2018) |
| "Morris water maze test was used to evaluate learning and memory deficits in pilocarpine-induced chronic epilepsy rats 12 weeks after status epilepticus." | 3.88 | Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A [ ( Cheng, DF; Ding, J; Shi, HC; Si, Z; Wang, X; Wu, XQ; Zhao, YN, 2018) |
| "Rat models of epilepsy were induced by pilocarpine hydrochloride." | 3.88 | Disruption of GluR2/GAPDH Complex Interaction by TAT-GluR2 ( Liu, J; Mi, Q; Wang, J; Yao, G; Zhang, GY; Zhang, J; Zhao, P, 2018) |
| " Therefore, the aim of this study was to verify the role of long-term treatment with vitamin E in rats submitted to the pilocarpine model of epilepsy." | 3.88 | Long-term monotherapy treatment with vitamin E reduces oxidative stress, but not seizure frequency in rats submitted to the pilocarpine model of epilepsy. ( Colugnati, DB; Cysneiros, RM; de Lima, E; Ferrari, D; Ghazale, PP; Janjoppi, L; Pansani, AP; Scorza, FA; Sinigaglia-Coimbra, R, 2018) |
| " The first experimental block included a Pilocarpine rat model of epilepsy, in which a magnetic neodymium nickel-plated cylinder, a magnetic field of 0." | 3.88 | Static magnetic fields reduce epileptiform activity in anesthetized rat and monkey. ( Aguila, J; Aguilar, J; Coletti, M; Cudeiro, J; Prieto, S; Rivadulla, C, 2018) |
| " The epilepsy model was induced by injection of pilocarpine in rats." | 3.88 | [Efficacy of brain-targeted rapamycin for treatment of epilepsy in rats]. ( Dong, J; Liu, L; Wang, Q; Zeng, L; Zhang, B; Zhang, Y; Zhu, F, 2018) |
| "We studied early alterations in the GABAergic system of the rat hippocampus in the lithium-pilocarpine model of epilepsy." | 3.85 | Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy. ( Karyakin, VB; Magazanik, LG; Vasil'ev, DS; Zaitsev, AV; Zhuravin, IA, 2017) |
| "The present results indicate that tangeretin exerted potent neuroprotective effects against pilocarpine-induced seizures via the activation of PI3K/Akt signaling and the regulation of MMPs." | 3.85 | Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway. ( Cao, YL; Guo, XQ; Hao, F; Liu, XW; Wang, ML; Yan, ZR, 2017) |
| "We aimed to discuss the mechanism of occurrence and progression of epilepsy through analyzing the expression changes of UCA1 and NF-Kb in temporal hippocampus and UCA1 in peripheral blood in rats with epilepsy induced by lithium chloride-pilocarpine." | 3.85 | Dynamic regulation effect of long non-coding RNA-UCA1 on NF-kB in hippocampus of epilepsy rats. ( Wang, HK; Wang, J; Wang, K; Yan, H, 2017) |
| "Transplantation of progenitor cells from embryonic medial or caudal ganglionic eminence (MGE, CGE) were made in a well-characterized mouse model of status epilepticus-induced epilepsy (systemic pilocarpine)." | 3.85 | Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors. ( Baraban, SC; Casalia, ML; Howard, MA, 2017) |
| "The aim of the present study was to investigate the role of paroxetine intervention in epilepsy, and its association with the expression of serotonin transporter (SERT) and hippocampal apoptosis." | 3.85 | Novel insights into the effect of paroxetine administration in pilocarpine‑induced chronic epileptic rats. ( Huang, HP; Li, XF; Lin, MX; Lin, WH; Zhou, Y, 2017) |
| " We examined the protein expression levels of hippocampal Cx36 (the prominent Cx present between GABAergic interneurons) and Cx43 (the main Cx expressed by astrocytes) during epileptogenesis in the pilocarpine model of epilepsy." | 3.85 | Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy. ( Babapour, V; Mahdian, R; Motaghi, S; Sayyah, M, 2017) |
| " Inhibition of SALM3 by SALM3 shRNA inhibited status epilepticus in the acute stage of disease and decreased spontaneous recurrent seizures in the Lithium-pilocarpine model of chronic stages of epilepsy." | 3.85 | Effect of synaptic adhesion-like molecule 3 on epileptic seizures: Evidence from animal models. ( Chen, L; Jiang, G; Li, J; Wang, N; Wu, Y; Zhang, Y, 2017) |
| " We performed long-term video-EEG monitoring of 16 epileptic rats after pilocarpine-induced status epilepticus and five control animals." | 3.83 | Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats. ( Bajorat, R; Brenndörfer, L; Goerss, D; Kirschstein, T; Köhling, R; Schwabe, L, 2016) |
| " A1 receptor agonists increase the latency for the development of seizures and status epilepticus following pilocarpine administration." | 3.83 | Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. ( Amorim, BO; Covolan, L; de Almeida, AG; Fernandes, MJS; Ferreira, E; Hamani, C; Miranda, MF; Rodrigues, AM, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "Pentylenetetrazol (PTZ)-induced chronic kindling model and lithium-pilocarpine-induced status epilepticus (SE) model were used in this study." | 3.81 | Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. ( Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F, 2015) |
| " monnieri extract in ameliorating pilocarpine induced temporal lobe epilepsy through regulation of 5-HT2C and NMDA receptors in cerebral cortex." | 3.81 | Alteration in 5-HT₂C, NMDA receptor and IP3 in cerebral cortex of epileptic rats: restorative role of Bacopa monnieri. ( Abraham, PM; Anju, TR; Krishnakumar, A; Paulose, CS, 2015) |
| " The main objective of this work was to investigate the effect of the selective 5-HT selective reuptake inhibitor (SSRI) fluoxetine administered subacutely (10mg/kg/day×7 days) on the eventual metabolic impairment induced by the lithium-pilocarpine model of epilepsy in rats." | 3.81 | Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2015) |
| "TO determine neuroprotective properties of levetiracetam and simvastatin using rats with pilocaroine-induced epilepsy." | 3.81 | [Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models]. ( Chen, T; Li, MQ; Liu, L; Zhang, WW, 2015) |
| " This study aimed to assess αSNAP expression in temporal lobe epilepsy (TLE) patients and pilocarpine-induced rat model and to determine whether altered αSNAP expression leads to increased susceptibility to seizures." | 3.81 | Association of Alpha-Soluble NSF Attachment Protein with Epileptic Seizure. ( Deng, W; Li, J; Mi, X; Wang, L; Wang, N; Wang, X; Wang, Z; Xi, Z; Xiao, F, 2015) |
| " Based on this, we measured the serum levels of C-reactive protein (CRP) and cytokines during acute, silent, and chronic phases of rats submitted to the pilocarpine model of epilepsy." | 3.81 | High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process? ( Cysneiros, RM; de Almeida, SS; de Brito, MV; Gouveia, TL; Naffah-Mazzacoratti, Mda G; Nejm, MB; Oliva, ML; Salu, BR; Scorza, FA; Vieira de Brito, JM; Vieira de Sousa, PV, 2015) |
| "Triheptanoin, the triglyceride of heptanoate, is anticonvulsant in various epilepsy models." | 3.80 | Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy. ( Borges, K; Hadera, MG; McDonald, TS; Smeland, OB; Sonnewald, U; Tan, KN, 2014) |
| "In the mouse pilocarpine-induced epilepsy model, we administered levetiracetam (LEV) and valproate (VPA) in sequence." | 3.80 | Unique behavioral characteristics and microRNA signatures in a drug resistant epilepsy model. ( Ban, JJ; Choi, J; Chu, K; Jeon, D; Jung, KH; Khalid, A; Kim, JM; Lee, SK; Lee, ST; Moon, J; Park, KI; Shin, JW; Yang, H; Yi, GS, 2014) |
| "In vivo mGluR5 images were acquired using [11C]ABP688 microPET/CT in pilocarpine-induced chronic epilepsy rat models and controls." | 3.80 | In vivo imaging of mGluR5 changes during epileptogenesis using [11C]ABP688 PET in pilocarpine-induced epilepsy rat model. ( Choi, H; Chung, JK; Hwang, DW; Im, HJ; Jeong, JM; Kang, H; Kim, EE; Kim, YK; Lee, B; Lee, DS; Lee, YS; Oh, SW, 2014) |
| " A similar profusion of immature GABAergic cells was seen in rats with pilocarpine-induced chronic epilepsy." | 3.80 | Transient muscarinic and glutamatergic stimulation of neural stem cells triggers acute and persistent changes in differentiation. ( DeFranco, DB; Di Maio, R; Kanuparthi, PS; Samarasinghe, RA; Timothy Greenamyre, J, 2014) |
| "To explore the effects of neuronal Per-Arnt-Sim domain protein 4 (Npas4) on seizures in pilocarpine-induced epileptic rats, Npas4 expression was detected by double-label immunofluorescence, immunohistochemistry, and Western blotting in the brains of pilocarpine-induced epileptic model rats at 6 h, 24 h, 72 h, 7 d, 14 d, 30 d, and 60 d after status epilepticus." | 3.80 | The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats. ( Guo, J; Hu, R; Long, X; Ren, M; Shen, W; Wang, D; Wang, X; Yang, G; Zeng, K, 2014) |
| "Behaviors of calcium/calmodulin-dependent protein kinase II alpha (α-CaMKII) heterozygous knock-out (KO) mice, which are a representative bipolar disorder/schizophrenia model displaying iDG, and pilocarpine-treated mice, which are a representative epilepsy model, were tested followed by quantitative polymerase chain reaction (qPCR)/immunohistochemistry for mRNA/protein expression associated with an iDG phenotype." | 3.79 | The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease. ( Chen, Q; Gross, AK; Hagihara, H; Heusner, CL; Kobayashi, K; Kogan, JH; Matsumoto, M; Miyakawa, T; Miyake, S; Shin, R; Tajinda, K; Tamura, K; Walton, NM, 2013) |
| "To analyze the survival and the changes of proportions of Calbindin, Calretinin and Parvalbumin positive neurons in mouse hippocampal CA area at chronic stage of Pilocarpine-induced epilepsy." | 3.79 | [Survival of calbindin, calretinin and parvalbumin positive neurons in mouse hippocampal CA area at chronic stage of pilocarpine-induced epilepsy]. ( Liu, J; Liu, Y; Tang, F, 2013) |
| " NKCC1 or KCC2 expression changes have been demonstrated previously in the hippocampal neurons of mice with pilocarpine-induced status epilepticus (PISE)." | 3.79 | STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy. ( Cai, X; Chen, S; Chen, Y; Chen, Z; Fang, Z; Wang, Q; Yang, L; Zhou, J; Zhou, L, 2013) |
| " Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P < 0." | 3.79 | Hypoxia markers are expressed in interneurons exposed to recurrent seizures. ( Biagini, G; Gualtieri, F; Longo, D; Marinelli, C; Meletti, S; Nichelli, PF; Pugnaghi, M, 2013) |
| "Both proconvulsive and anticonvulsive roles of leptin have been reported, suggesting cell-specific actions of leptin in different models of seizure and epilepsy." | 3.79 | Protective role of astrocytic leptin signaling against excitotoxicity. ( Hsuchou, H; Jayaram, B; Kastin, AJ; Khan, RS; Pan, W; Wu, X, 2013) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 3.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| " The endocannabinoid system is known to modulate seizure activity in several in vivo and in vitro models, and CB(1) -receptor activation is anticonvulsant in the rat pilocarpine model of acquired epilepsy (AE)." | 3.78 | Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain. ( Blair, RE; DeLorenzo, RJ; Nguyen, PT; Sayers, KW; Sim-Selley, LJ, 2012) |
| " The pilocarpine model in rodents reproduces the main features of mesial temporal lobe epilepsy related to hippocampus sclerosis (MTLE-HS) in humans." | 3.78 | Time-dependent modulation of mitogen activated protein kinases and AKT in rat hippocampus and cortex in the pilocarpine model of epilepsy. ( de Cordova, FM; de Mello, N; Leal, RB; Lopes, MW; Nunes, JC; Soares, FM; Walz, R, 2012) |
| " The present study aimed to test the feasibility of using manganese-enhanced magnetic resonance imaging (MEMRI) to detect MFS in the chronic phase of the well-established pilocarpine (Pilo) rat model of temporal lobe epilepsy (TLE)." | 3.78 | Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy. ( Covolan, L; Longo, BM; Malheiros, JM; Mello, LE; Paiva, FF; Polli, RS; Silva, AC; Tannús, A, 2012) |
| "To investigate the relationship between serotonin (5-HT) and epilepsy and the mechanism of learning-memory in pilocarpine (PILO)-induced epileptic rats after 5,7-dihydroxytryptamine (5,7-DHT) microinjection in median raphe nucleus." | 3.78 | [Effect of serotonin depletion on seizures learning-memory in pilocarpine-induced epileptic rats]. ( Chen, SG; Huang, HP; Lin, WH; Lv, XC, 2012) |
| " We assessed the susceptibility to epilepsy after subthreshold dose of pilocarpine, as well as glial fibrillary acidic protein (GFAP) expression using immunohistochemistry." | 3.78 | Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine. ( Feng, B; Pan, XH; Sun, HL; Wang, CY; Xu, Y; Yang, LX; Zhang, SH; Zhang, SP; Zhong, K; Zhu, W, 2012) |
| " In this study, we investigated DZ attenuating neuronal loss caused by pilocarpine-induced seizures in rat hippocampus." | 3.77 | Diazoxide preconditioning against seizure-induced oxidative injury is via the PI3K/Akt pathway in epileptic rat. ( Cao, L; Chi, Z; Jiang, H; Xie, N; Xue, Y; Zhao, X, 2011) |
| "The effects of ALAC administered per os were evaluated by standard protocols against audiogenic seizures in Genetic Epilepsy Prone Rats (GEPR-9 rats), maximal electroshock (MES)-induced seizures in rats, pilocarpine-induced seizures in mice, spontaneous chronic seizures in mice exposed to pilocarpine-induced status epilepticus (SE), and absence seizures in WAG/Rij rats." | 3.77 | Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy. ( Citraro, R; De Fazio, S; De Sarro, G; Mainardi, P; Perucca, E; Raggio, R; Russo, E; Scicchitano, F, 2011) |
| "The present paper is the first work to determine the effect of lipopolysaccharide (LPS) in the pilocarpine model of epilepsy on the morphology of rat hippocampal astrocytes in vivo." | 3.77 | Investigations of hippocampal astrocytes in lipopolysaccharide-preconditioned rats in the pilocarpine model of epilepsy. ( Cybulska, R; Dmowska, M; Jaworska-Adamu, J; Krawczyk, A; Pawlikowska-Pawlęga, B, 2011) |
| "To evaluate a potential insult in the cerebellum of pups exposed to maternal epileptic seizures during intrauterine life, female rats were subjected to pilocarpine-induced epilepsy." | 3.77 | Neuroglobin is up-regulated in the cerebellum of pups exposed to maternal epileptic seizures. ( Amado, D; Cavalheiro, EA; Cossa, AC; da Graça Naffah-Mazzacoratti, M; da Silva Fernandes, MJ; da Silva, IR; da Silva, JA; de Oliveira, EM; Higa, EM; Lima, DC; Perosa, SR, 2011) |
| "Acute application of human ASCs-E before SE led to earlier attenuation of seizure spike activities after treatment with diazepam, reduction of BBB leakage, and inhibition of the development of epilepsy." | 3.77 | A cell-free extract from human adipose stem cells protects mice against epilepsy. ( Ban, JJ; Chu, K; Jeon, D; Jung, KH; Kang, KM; Kim, M; Kim, S; Lee, SK; Lee, ST; Roh, JK; Seo, JS; Won, CH, 2011) |
| " This "period without stimulus" was used to observe the influence of early physical exercise on susceptibility to seizures induced by the pilocarpine model of epilepsy at P150." | 3.77 | Early physical exercise and seizure susceptibility later in life. ( Arida, RM; Cavalheiro, EA; de Almeida, AA; Gomes da Silva, S; Scorza, FA; Silva Araújo, BH, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 3.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| "Status epilepticus was induced in the rats by administration of pilocarpine 350 mg/kg i." | 3.77 | Piperine protects epilepsy associated depression: a study on role of monoamines. ( Nayak, S; Pal, A; Sahu, PK; Swain, T, 2011) |
| "Chronic epilepsy was elicited after status epilepticus (SE) induced by lithium-pilocarpine in adult Wistar rats." | 3.76 | Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine. ( Guo, Y; Jiang, L, 2010) |
| " We examined whether pharmacological blockade of hippocampal interleukin-1 receptor exerts antidepressant effects in an animal model of comorbidity between TLE and depression, which developed in Wistar rats following pilocarpine status epilepticus (SE)." | 3.76 | Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta. ( Mazarati, AM; Pineda, E; Sankar, R; Shin, D; Taylor, AN; Tio, D, 2010) |
| " We induced status epilepticus (SE) with pilocarpine in adult rats, and investigated endothelial cell proliferation (BrdU and rat endothelial cell antigen-1 (RECA-1) double-labeling), vessel length (unbiased stereology), thrombocyte aggregation (thrombocyte immunostaining), neurodegeneration (Nissl staining), neurogenesis (doublecortin (DCX) immunohistochemistry), and mossy fiber sprouting (Timm staining) in the hippocampus at different time points post-SE." | 3.76 | Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. ( Gröhn, O; Hayward, N; Ndode-Ekane, XE; Pitkänen, A, 2010) |
| "Levetiracetam (LEV, 2S-(oxo-1-pyrrolidinyl)butanamide, Keppra, UCB Pharma) is a new anti-epileptic drug used to treat certain types of seizures in epilepsy patients." | 3.76 | Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. ( Choi, HC; Choi, SY; Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Song, HK, 2010) |
| "Changes in the transcriptome of hippocampal cells from rats subjected to the pilocarpine model of epilepsy were evaluated by microarrays covering 34,000 transcripts representing all annotated rat genes to date." | 3.76 | Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis. ( Bonone, FM; Cavalheiro, EA; da Silva, AV; Janjoppi, L; Okamoto, OK; Pansani, AP; Scorza, FA, 2010) |
| " An epilepsy model was induced in female rats by administration of pilocarpine." | 3.76 | Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures. ( Amado, D; Arganãraz, GA; Cavalheiro, EA; Frussa-Filho, R; Lima, DC; Naffah-Mazzacoratti, Mda G; Vale, TG; Varella, PP, 2010) |
| " Pilocarpine was administered to induce status epilepticus." | 3.76 | Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus. ( Choy, M; Gadian, DG; Lythgoe, MF; Scott, RC; Thomas, DL; Wells, JA, 2010) |
| "Extreme obesity slowly develops in female rats over the months following seizures induced by a single systemic injection of lithium and pilocarpine if the resulting limbic seizures are treated with the atypical neuroleptic acepromazine (but not with ketamine)." | 3.75 | Insidious weight gain in prepubertal seized rats treated with an atypical neuroleptic: the role of food consumption, fluid consumption, and spontaneous ambulatory activity. ( Bubenik, GA; Parker, GH; Persinger, MA; St-Pierre, LS, 2009) |
| "To analyze cellular mechanisms of limbic-seizure suppression, the response to pilocarpine-induced seizures was investigated in cortex and thalamus, comparing epilepsy-resistant rats Proechimys guyannensis with Wistar rats." | 3.75 | Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Spreafico, R, 2009) |
| "The lithium-pilocarpine model of epilepsy in rat has been used extensively to investigate basic mechanisms of epilepsy and mimics human temporal lobe epilepsy." | 3.75 | Longitudinal microPET imaging of brain glucose metabolism in rat lithium-pilocarpine model of epilepsy. ( Dupont, P; Goffin, K; Van Laere, K; Van Paesschen, W, 2009) |
| "To investigate whether anterior thalamic nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy." | 3.75 | Bilateral anterior thalamic nucleus lesions are not protective against seizures in chronic pilocarpine epileptic rats. ( Ballester, G; Bonilha, SM; Covolan, L; Ewerton, FI; Fantin Cavarsan, C; Hamani, C; Lozano, AM; Marcolin de Almeida, F; Mello, LE, 2009) |
| " To determine if a single event of status epilepticus and its latent consequences can affect motor map expression, we assessed forelimb motor maps in rats using the pilocarpine model of temporal lobe epilepsy." | 3.75 | Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain. ( Flynn, C; Ozen, LJ; Teskey, GC; Vuong, J; Young, NA, 2009) |
| " The muscarinic convulsant pilocarpine was used to elicit status epilepticus (SE) in adult female Sprague Dawley rats." | 3.75 | A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures. ( Friedman, D; Harden, CL; Maclusky, NJ; Malthankar-Phatak, GH; McCloskey, DP; Pearce, P; Scharfman, HE, 2009) |
| " Moreover, pilocarpine induced a significant down-regulation of APLP1 mRNA expression at 6 h after epilepsy initiation (P< 0." | 3.75 | Down-regulation of APLP1 mRNA expression in hippocampus of pilocarpine-induced epileptic rats. ( Wang, C; You, ZL; Zhang, DD, 2009) |
| "In rodents, the cholinomimetic convulsant pilocarpine is widely used to induce status epilepticus (SE), followed by hippocampal damage and spontaneous recurrent seizures, resembling temporal lobe epilepsy." | 3.75 | Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice. ( Gröticke, I; Hoffmann, K; Löscher, W; Müller, CJ; Schughart, K, 2009) |
| "In the present study, we explored the consequences of epilepsy on the neurobehavioral development of the offspring in a rat model of spontaneous epilepsy, the lithium-pilocarpine model of temporal lobe epilepsy not dependent on genetic factors and in animals not receiving any antiepileptic treatment." | 3.75 | Neurobehavioral maturation of offspring from epileptic dams: study in the rat lithium-pilocarpine model. ( Boehrer, A; de Vasconcelos, AP; Desor, D; Nehlig, A; Raffo, E, 2009) |
| " Using the epilepsy model obtained by systemic administration of pilocarpine in rats, we investigated the lipid peroxidation, nitrite content, superoxide dismutase (SOD) and catalase activities in the hippocampus of rats during chronic period." | 3.75 | Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine. ( Freitas, RM, 2009) |
| "Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence." | 3.75 | Alcohol consumption and sudden unexpected death in epilepsy: experimental approach. ( Arida, RM; Cavalheiro, EA; Cysneiros, RM; de Almeida, AC; Machado, HR; Scorza, FA; Scorzai, CA; Terra, VC, 2009) |
| " In this study, we aimed to investigate the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus (PISE) and their relationship with epileptogenesis." | 3.74 | Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE). ( Chen, S; Chen, Z; Li, X; Zhou, J; Zhou, L; Zhu, F, 2008) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 3.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| " Animals (n = 14) were administered pilocarpine to induce status epilepticus." | 3.74 | Oral administration of fructose-1,6-diphosphate has anticonvulsant activity. ( Lian, XY; Stringer, JL; Xu, K, 2008) |
| "Recently we reported that astroglial loss and subsequent gliogenesis in the dentate gyrus play a role in epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 3.74 | Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus. ( Choi, KC; Choi, SY; Kang, TC; Kim, DS; Kim, DW; Kim, JE; Kwak, SE; Kwon, OS, 2008) |
| " Present studies were carried out to decipher seizure-dependent changes in mitochondrial function and ultrastructure in the chronic condition of temporal lobe epilepsy (TLE) induced by pilocarpine in rat hippocampus." | 3.74 | Mitochondrial dysfunction and ultrastructural damage in the hippocampus of pilocarpine-induced epileptic rat. ( Chi, ZF; Gao, J; Liu, XW; Shan, PY; Wang, R, 2007) |
| "Ecto-nucleotidases, one of the main mechanisms involved in the control of adenosine levels in the synaptic cleft, have shown increased activities after the pilocarpine model of epilepsy." | 3.74 | Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. ( Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ, 2007) |
| "Sixty-one SD rats underwent intraperitoneal injection of lithium chloride and pilocarpine to establish models of status epilepticus characterized with temporal lobe epilepsy." | 3.74 | [Correlation between hippocampal mossy fiber sprouting and synaptic reorganization and mechanisms of temporal lobe epilepsy]. ( Chen, YC; Huang, YG; Lin, H; Wen, XN; Wu, LW, 2007) |
| " Electron microscopic immunolabeling was therefore used to determine if mossy cell axon terminals form synapses with hilar EGC dendrites, using animals that underwent pilocarpine-induced status epilepticus." | 3.74 | Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures. ( McCloskey, DP; Pierce, JP; Punsoni, M; Scharfman, HE, 2007) |
| " Our study showed that there was an increased CD40 expression on activated microglia in the brain injury after lithium pilocarpine-induced status epilepticus (SE) in rats." | 3.74 | Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. ( Deng, Y; Huang, Y; Li, R; Li, Y; Sun, H; Yang, J; Yu, X; Zhao, G, 2008) |
| "Kainic acid was administered in repeated low doses (5 mg/kg) every hour until each Sprague-Dawley rat experienced convulsive status epilepticus for >3 h." | 3.73 | Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy. ( Chapman, PL; Dudek, FE; Ferraro, DJ; Grabenstatter, HL; Williams, PA, 2005) |
| " We studied the nestin distribution in the hippocampal formation of rats submitted to pilocarpine model of epilepsy." | 3.73 | Expression of nestin in the hippocampal formation of rats submitted to the pilocarpine model of epilepsy. ( Arida, RM; Cavalheiro, EA; Naffah-Mazzacoratti, MG; Scorza, CA; Scorza, FA, 2005) |
| "Systemic administration of pilocarpine preceded by lithium induces status epilepticus (SE) that results in neurodegeneration and may lead to the development of spontaneous recurrent seizures." | 3.73 | Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus. ( Bissoon, N; Gurd, JW; Ikeda-Douglas, C; Milgram, NW; Moussa, R; Niimura, M, 2005) |
| "Here we investigated the effects of electroacupuncture over the cognitive deficits in the pilocarpine model of epilepsy in rats." | 3.73 | Electroacupuncture prevents cognitive deficits in pilocarpine-epileptic rats. ( Blanco, MM; de Oliveira Freire, A; do Monte, FH; Dos Santos, JG; Mello, LE; Tabosa, A, 2005) |
| " In the pilocarpine and KA models, doses lower than those used in Wistar rats were able to induce status epilepticus (SE) in PG animals." | 3.73 | Proechimys guyannensis: an animal model of resistance to epilepsy. ( Arida, RM; Cavalheiro, EA; de Amorim Carvalho, R; Scorza, FA, 2005) |
| " It has been previously reported that ectonucleotidase activities are increased in female adult rats submitted to the pilocarpine model of epilepsy." | 3.73 | Ontogenetic profile of ectonucleotidase activities from brain synaptosomes of pilocarpine-treated rats. ( Bonan, CD; Bruno, AN; de Paula Cognato, G; Sarkis, JJ; Vuaden, FC, 2005) |
| " In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2h during pilocarpine induced status epilepticus, and never recovered." | 3.73 | Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. ( Burgunder, JM; Chang, ML; Chia, SC; Ma, DL; Probst, A; Tang, FR; Tang, YC, 2006) |
| " Because OX-A is known to exert excitatory actions in the hippocampus, we hypothesized that the level of OXs targeted toward the hippocampus may be increased following status-epilepticus (SE)-induced epileptogenesis in the rat pilocarpine model of temporal lobe epilepsy." | 3.73 | Unexpected expression of orexin-B in basal conditions and increased levels in the adult rat hippocampus during pilocarpine-induced epileptogenesis. ( Bezin, L; Bonnet, C; Bourgoin, N; Georges, B; Laglaine, A; Morales, A; Moulin, C; Nadam, J; Navarro, F; Pequignot, JM; Touvier, T, 2006) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 3.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| "Apnea is known to occur during seizures, but systematic studies of ictal respiratory changes in adults are few." | 3.72 | Respiratory pattern in a rat model of epilepsy. ( Campos, RR; Mello, LE; Tolentino-Silva, FR, 2003) |
| "The rodent pilocarpine model of epilepsy exhibits hippocampal sclerosis and spontaneous seizures and thus resembles human temporal lobe epilepsy." | 3.72 | Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. ( Almonte, AG; Borges, K; Dingledine, R; Gearing, M; McDermott, DL; Smith, AB; Wainer, BH, 2003) |
| " We have, therefore, analysed the effects of phenytoin (100 micro m), lamotrigine (100 micro m) and valproate (600 micro m) on Na+ currents in dissociated rat hippocampal granule neurons in the pilocarpine model of chronic epilepsy." | 3.72 | Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats. ( Beck, H; Elger, CE; Remy, S; Urban, BW, 2003) |
| " Most animals present seizures at rest rather than during exercise and LCMRglu was measured during the interictal phase of the chronic period of a pilocarpine model of epilepsy by the [14C]2-deoxyglucose (2DG) method." | 3.72 | Physical training does not influence interictal LCMRglu in pilocarpine-treated rats with epilepsy. ( Arida, RM; Cavalheiro, EA; Fernandes, MJ; Preti, SC; Scorza, FA, 2003) |
| " The rats subjected to lithium-pilocarpine (Li/PC)-induced status epilepticus at P21 were grouped as the SE group." | 3.72 | Long-term effects of early-life malnutrition and status epilepticus: assessment by spatial navigation and CREB(Serine-133) phosphorylation. ( Hsieh, CS; Huang, LT; Lai, MC; Liou, CW; Wang, CA; Wang, CL; Yang, CH; Yang, SN, 2003) |
| " To assess this hypothesis, the pilocarpine model of temporal lobe epilepsy was selected because an important reorganization of the glutamatergic network, which includes an aberrant sprouting of granule cell axons, neo-synaptogenesis, and dendritic spine remodeling, is well established in the dentate gyrus." | 3.72 | Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures. ( Ben-Ari, Y; Esclapez, M; Fattoum, A; Ferhat, L; Represa, A; Shirao, T, 2003) |
| " In order to test whether the revealed abnormalities give rise to increased susceptibility to seizures in TN-R-deficient mice, we used the pilocarpine model of epilepsy." | 3.72 | Mice deficient for the extracellular matrix glycoprotein tenascin-r show physiological and structural hallmarks of increased hippocampal excitability, but no increased susceptibility to seizures in the pilocarpine model of epilepsy. ( Brenneke, F; Bukalo, O; Dityatev, A; Lie, AA, 2004) |
| "At 4 h during pilocarpine-induced status epilepticus (DPISE) in rat, protein kinase C (PKC)beta1, PKCbeta2, and PKCgamma were induced at the border between the stratum oriens and alveus (O/A border) of CA1 in the hippocampus." | 3.72 | Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus. ( Chen, Y; Chia, SC; Gao, H; Lee, WL; Loh, YT; Tang, FR, 2004) |
| "A pilocarpine-induced SRS model of epilepsy affords a reliable model of epileptogenesis suitable for evaluating new chemical entities as putative antiepileptogenics." | 3.72 | Implementing a bioassay to screen molecules for antiepileptogenic activity: chronic pilocarpine versus subdudral haematoma models. ( Lyon, A; Marone, S; Wainman, D; Weaver, DF, 2004) |
| " Here, we examine two neuroprotective agents, the noncompetitive NMDA antagonist ketamine and the dopaminergic antagonist acepromazine, for their efficacy in attenuating cognitive impairments in the lithium-pilocarpine (LI-PILO) model of rat limbic epilepsy." | 3.72 | Normal spatial and contextual learning for ketamine-treated rats in the pilocarpine epilepsy model. ( McKay, BE; Persinger, MA, 2004) |
| "Thirty days after the induction of seizures in 16 rats with lithium (3 mEq/kg) and pilocarpine (30 mg/kg), the numbers of episodes of motor seizures (rapid forelimb clonus) during daily 10-minute observational periods were recorded for 11 months." | 3.72 | Emergence of spontaneous seizures during the year following lithium/pilocarpine-induced epilepsy and neuronal loss within the right temporal cortices. ( Dupont, MJ; Persinger, MA, 2004) |
| " BDNF mRNA and protein accumulate in dendrites in all hippocampal subfields after pilocarpine seizures and in selected subfields after other epileptogenic stimuli (kainate and kindling)." | 3.72 | Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. ( Armellin, M; Bregola, G; Cattaneo, A; Giulianini, PG; Paradiso, B; Simonato, M; Steward, O; Tongiorgi, E; Zucchini, S, 2004) |
| " Neural activation was studied in the Proechimys hippocampus, using Fos induction, within 24 h after pilocarpine-induced seizures; neurodegenerative events were investigated in parallel, using FluoroJade B histochemistry." | 3.72 | Fos induction and persistence, neurodegeneration, and interneuron activation in the hippocampus of epilepsy-resistant versus epilepsy-prone rats after pilocarpine-induced seizures. ( Andrioli, A; Bentivoglio, M; Cavalheiro, EA; Fabene, PF; Priel, MR, 2004) |
| "We studied the effects of TPM on mitochondrial function in the pilocarpine rat model of chronic epilepsy and in isolated mitochondria from rat brain." | 3.72 | The mechanism of neuroprotection by topiramate in an animal model of epilepsy. ( Debska-Vielhaber, G; Elger, CE; Kudin, AP; Kunz, WS; Vielhaber, S, 2004) |
| "This study addresses the question of epileptogenesis by investigating the effects of carbamazepine (CBZ) on the silent period of the pilocarpine model of epilepsy." | 3.71 | Effect on epileptogenesis of carbamazepine treatment during the silent period of the pilocarpine model of epilepsy. ( Capella, HM; Lemos, T, 2002) |
| "Fluoxetine (20 mg/kg) and TFMPP (5 mg/kg) were administered to rats with pilocarpine-induced epilepsy." | 3.71 | Effects of fluoxetine and TFMPP on spontaneous seizures in rats with pilocarpine-induced epilepsy. ( Dudek, FE; Hernandez, EJ; Williams, PA, 2002) |
| "The aim of the study was to detect by texture analysis non easily visible anomalies of magnetic resonance (MR) images of piriform and entorhinal cortices relevant to the lithium-pilocarpine (Li-Pilo) model of temporal lobe epilepsy in rats." | 3.71 | Detection of late epilepsy by the texture analysis of MR brain images in the lithium-pilocarpine rat model. ( Chambron, J; Mauss, Y; Namer, IJ; Roch, C; Yu, O, 2002) |
| "At variance with pilocarpine-induced epilepsy in the laboratory rat, pilocarpine administration to the tropical rodent Proechimys guyannensis (casiragua) elicited an acute seizure that did not develop in long-lasting status epilepticus and was not followed by spontaneous seizures up to 30 days, when the hippocampus was investigated in treated and control animals." | 3.71 | The spiny rat Proechimys guyannensis as model of resistance to epilepsy: chemical characterization of hippocampal cell populations and pilocarpine-induced changes. ( Bentivoglio, M; Carvalho, RA; Cavalheiro, EA; Correia, L; Fabene, PF, 2001) |
| " Using the epilepsy model obtained by systemic administration of pilocarpine (PILO) in rats, we investigated the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as well as the hydroperoxide (HPx) concentration in the hippocampus of rats during status epilepticus (SE), silent and chronic periods." | 3.71 | Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats. ( Abdalla, DS; Amado, D; Bellissimo, MI; Cavalheiro, EA; Ferreira, EC; Naffah-Mazzacoratti, MG, 2001) |
| " Here we have decided to investigate the participation of the GABAergic system of the zona incerta, one of its major neurotransmitters with widespread projections to the neocortex, in the pilocarpine (Pilo) model of epilepsy." | 3.71 | Inhibitory role of the zona incerta in the pilocarpine model of epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Hamani, C; Mello, LE; Sakabe, S, 2002) |
| " The pilocarpine model of limbic epilepsy involves inducing status epilepticus (SE) with the subsequent development of spontaneous recurrent seizures (SRSs) and is widely accepted as a model of limbic epilepsy in humans." | 3.70 | NMDA receptor activation during status epilepticus is required for the development of epilepsy. ( DeLorenzo, RJ; Rice, AC, 1998) |
| "Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both." | 3.70 | Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: a qualitative study. ( Calderazzo, L; Cavalheiro, EA; Sanabria, ER; Scorza, FA, 1998) |
| " In the present study, glutamatergic modulation of GABAA receptor-mediated inhibition was investigated by whole-cell patch clamp recordings from visualized hippocampal dentate granule cells (DGCs) in slices that were prepared from surgically-removed human medial temporal lobe specimens and the rat pilocarpine model of temporal lobe epilepsy." | 3.70 | Modulation of GABAA receptor-mediated inhibition by postsynaptic calcium in epileptic hippocampal neurons. ( Isokawa, M, 1998) |
| "Systemic administration of pilocarpine, which results in status epilepticus followed by recurrent seizures in rats, is a widely used experimental model of chronic limbic epilepsy." | 3.70 | Persistence and atrophy of septal/diagonal band neurons expressing the p75 neurotrophin receptor in pilocarpine-induced chronic epilepsy in the rat. ( Amado, D; Bentivoglio, M; Cavalheiro, EA; Correia, L, 1998) |
| " Pilocarpine-treated rats present status epilepticus, which is followed by a seizure-free period (silent), by a period of spontaneous recurrent seizures (chronic), and the hippocampus of these animals exhibits cell loss and mossy fiber sprouting." | 3.70 | Selective alterations of glycosaminoglycans synthesis and proteoglycan expression in rat cortex and hippocampus in pilocarpine-induced epilepsy. ( Amado, D; Argañaraz, GA; Bellissimo, MI; Cavalheiro, EA; Nader, HB; Naffah-Mazzacoratti, MG; Porcionatto, MA; Scorza, FA; Silva, R, 1999) |
| "We tested the sensitivity of PrPc knockout mice to seizures induced by single convulsant or repeated subconvulsant (kindling) doses of pentylenetetrazol (PTZ), and to status epilepticus (SE) induced by kainic acid or pilocarpine." | 3.70 | Increased sensitivity to seizures in mice lacking cellular prion protein. ( Amaral, OB; Brentani, RR; Cavalheiro, EA; Izquierdo, I; Martins, VR; Rockenbach, IC; Roesler, R; Walz, R, 1999) |
| "Pilocarpine (PILO) administered to rats acutely induces status epilepticus (acute period), which is followed by a transient seizure-free period (silent period), and finally by a chronic phase of spontaneous recurrent seizures (chronic period, SRS) that lasts for the rest of animal's life." | 3.69 | Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. ( Bellíssimo, MI; Cavalheiro, EA; Naffah-Mazzacoratti, MG, 1995) |
| "Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice." | 3.69 | The pilocarpine model of epilepsy in mice. ( Cavalheiro, EA; Priel, MR; Santos, NF, 1996) |
| " To study the age-related susceptibility to the development of chronic epilepsy we used the pilocarpine model of epilepsy (PME)." | 3.69 | Developmental aspects of the pilocarpine model of epilepsy. ( Cavalheiro, EA; dos Santos, NF; Priel, MR, 1996) |
| "Following pilocarpine-induced status epilepticus, rats become chronically epileptic showing 2-3 spontaneous recurrent seizures per week." | 3.69 | Blockade of spreading depression in chronic epileptic rats: reversion by diazepam. ( Cavalheiro, EA; Guedes, RC, 1997) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 3.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "Pilocarpine-induced status epilepticus leads to widespread limbic forebrain damage in rats and provides a model for studying intractable epilepsy." | 3.68 | Some evidence that intrahippocampal grafting of noradrenergic neurons suppresses spontaneous seizures in epileptic rats. ( Bortolotto, ZA; Calderazzo, L; Cavalheiro, EA, 1990) |
| "Interictal activity and seizures are the hallmarks of focal epileptic disorders (which include mesial temporal lobe epilepsy, MTLE) in humans and in animal models." | 3.01 | Evolution of interictal activity in models of mesial temporal lobe epilepsy. ( Avoli, M; Lévesque, M; Macey-Dare, ADB; Salami, P; Wang, S, 2023) |
| "Limbic seizures can be mimicked in vitro using preparations of combined hippocampus-entorhinal cortex slices perfused with artificial cerebrospinal fluid containing convulsants or nominally zero Mg(2+), in order to produce epileptiform synchronization." | 2.41 | Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. ( Avoli, M; Biagini, G; D'Antuono, M; D'Arcangelo, G; Köhling, R; Louvel, J; Pumain, R; Tancredi, V, 2002) |
| "Long-term ANT-DBS significantly reduced seizure generalization in pilocarpine-induced epileptic rats." | 1.91 | Long-term ANT-DBS effects in pilocarpine-induced epileptic rats: A combined 9.4T MRI and histological study. ( Deng, J; Gao, JH; Guan, Y; Jing, B; Li, T; Liang, X; Luan, G; Tang, C; Wang, X; Xie, P; Xu, K; Zhou, J, 2023) |
| "Epilepsy is a common, chronic neurological disorder characterized by recurrent spontaneous seizures." | 1.91 | Upregulation of SLITRK5 in patients with epilepsy and in a rat model. ( Ai, M; Chen, H; Chen, L; Liu, Y; Mei, R; Pang, R; Xia, D; Zhang, L; Zhong, L, 2023) |
| "Berberine hydrochloride is a plant alkaloid with versatile medicinal applications, yet it has suffered from multiple limitations in its usage." | 1.91 | Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy. ( Aly, RG; El-Kamel, AH; El-Nahas, AE; Elbedaiwy, HM; Helmy, MW; Masoud, IM, 2023) |
| "Epilepsy is the most common chronic disorder in the nervous system, mainly characterized by recurrent, periodic, unpredictable seizures." | 1.91 | Phosphoglycerate kinase (PGK) 1 succinylation modulates epileptic seizures and the blood-brain barrier. ( Huang, H; Luo, Y; Tai, Z; Xu, Z; Yang, J; Zhang, H; Zhang, L, 2023) |
| "Epilepsy is one of the most common neurologic diseases, and around 30% of all epilepsies, particularly the temporal lobe epilepsy (TLE), are highly refractory to current pharmacological treatments." | 1.91 | A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes. ( Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á, 2023) |
| "After 3 hr of stage 5 acute seizure, hippocampal astrocytes show increased intrinsic calcium activity in stratum radiatum as well as reactive astrogliosis in the stratum lacunosum moleculare and hilus regions of the hippocampus." | 1.91 | Pilocarpine-induced acute seizure causes rapid area-specific astrogliosis and alters purinergic signaling in rat hippocampus. ( Harshad, PA; Joshi, NB; Joshi, PG; Singh, M; Tewari, BP, 2023) |
| "Then, the spontaneous recurrent seizure (SRS) latency, SRS frequency and seizure duration were observed in each group." | 1.91 | The neuroprotective effect of Dl-3-n-butylphthalide in epileptic rats via inhibiting endoplasmic reticulum stress. ( Cao, H; Jia, L; Niu, X; Qiao, Q; Qu, Z; Tian, S; Wang, W; Zhang, B, 2023) |
| "During the 90 min of SE, epileptic seizures were analyzed according to the Racine's Scale." | 1.91 | N-Formyl-Methionyl-Leucyl-Phenylalanine Plays a Neuroprotective and Anticonvulsant Role in Status Epilepticus Model. ( Anselmo-E-Silva, CI; Caixeta, DC; Costa, MA; de Castro, OW; de Melo, IS; de Paula Soares Mendonça, T; de Souza, FMA; Dos Santos, YMO; Freitas-Santos, J; Goulart, LR; Oliveira, KB; Pacheco, ALD; Sabino-Silva, R; Vaz, ER, 2023) |
| "Icariin has been identified that it could cross the blood-brain barrier and enter the hippocampus to exhibit therapeutic effects." | 1.91 | Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy. ( Feng, L; Liu, Y; Wang, J; Wu, Y; Yan, L; Yang, K, 2023) |
| "Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear." | 1.72 | MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy. ( Antonova, IV; Dyomina, AV; Griflyuk, AV; Kovalenko, AA; Postnikova, TY; Smolensky, IV; Zaitsev, AV; Zakharova, MV, 2022) |
| "ANT-DBS alleviated seizure activity, abnormal locomotor behaviors, reduced theta-band, increased gamma-band EEG power in the interictal state, and increased the number of neurons in the dentate gyrus (DG)." | 1.72 | Deep brain stimulation of the anterior nuclei of the thalamus can alleviate seizure severity and induce hippocampal GABAergic neuronal changes in a pilocarpine-induced epileptic mouse brain. ( Bae, S; Jeong, Y; Kim, SG; Lim, HK; Park, SM; Shon, YM; Suh, M, 2022) |
| "Epilepsy is one of the most common neurological disorders affecting most social, economic and biological aspects of human life." | 1.72 | Treatment of pilocarpine-induced epileptic seizures in adult male mice. ( Abdelbasset, WK; Huldani, H; Jalil, AT; Jasim, SA; Margiana, R; Mohammad, HJ; Ridha, HS; Rudiansyah, M; Yasin, G, 2022) |
| "Epilepsy is characterised by abnormal neuronal discharges, including aberrant expression of extracellular matrix (ECM) components and synaptic plasticity stabilisation." | 1.72 | Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the hippocampus of lithium-pilocarpine-induced acute epileptic rats. ( Chen, L; Huang, H; Huang, Q; Niu, J; Ren, J; Su, X; Sun, T; Wan, D; Wang, P; Yang, L; Zhang, C, 2022) |
| "Demyelination is observed in animal models of intractable epilepsy (IE)." | 1.62 | Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study. ( Chen, Z; Gu, J; Ma, K; Niu, J; Tao, S; Wang, P; Wang, S; Wei, S; Yang, L; Ye, M; Zhang, G; Zhang, L, 2021) |
| "Epilepsy was induced by pilocarpine, which was shown to produce long-lasting increases in NKCC1 in the hippocampus, whereas MEST did not alter NKCC1 mRNA in this region." | 1.62 | Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice. ( Gailus, B; Gericke, B; Hampel, P; Johne, M; Kaczmarek, E; Löscher, W; Römermann, K, 2021) |
| "Gastrodin has shown the potential as an anticonvulsant." | 1.62 | Gastrodin attenuates lithium-pilocarpine-induced epilepsy by activating AMPK-mediated PPARα in a juvenile rat model. ( Han, J; Li, Y; Wang, Y; Yang, Y, 2021) |
| "Epilepsy is one of the most frequent neurological disorders characterized by an enduring predisposition to generate epileptic seizures." | 1.62 | Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy. ( Al-Rafiah, AR; Mehdar, KM, 2021) |
| "Baicalein has multiple effects, including anti-inflammatory action." | 1.56 | Baicalein Ameliorates Epilepsy Symptoms in a Pilocarpine-Induced Rat Model by Regulation of IGF1R. ( Du, Z; Fu, P; Hu, J; Li, Z; Lv, K; Sun, Y; Wu, X; Yu, J; Yuan, Q, 2020) |
| "Kynurenic acid is an endogenous modulator of ionotropic glutamate receptors and a suppressor of the immune system." | 1.56 | Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104. ( Dulka, K; Földesi, I; Fülöp, F; Gulya, K; Kata, D; Lajkó, N; Mátyás, A; Mihály, A; Szabó, M; Vécsei, L, 2020) |
| "Epilepsy is a chronic and severe neurological disorder." | 1.51 | Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy. ( Gong, SJ; Huang, WL; Wu, ZS, 2019) |
| "Neurotrophic factors are candidates for treating epilepsy, but their development has been hampered by difficulties in achieving stable and targeted delivery of efficacious concentrations within the desired brain region." | 1.51 | Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy. ( Barbieri, M; Bell, WJ; Emerich, DF; Falcicchia, C; Fradet, T; Kokaia, M; Lovisari, F; Paolone, G; Simonato, M; Wahlberg, LU, 2019) |
| "Aucubin (AU) is an iridoid glycoside derived from Eucommia ulmoides that possesses anti-inflammatory and neuroprotective effects." | 1.51 | Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission. ( Chen, L; Chen, S; Hu, K; Huang, Q; Huang, X; Li, C; Ouyang, DS; Wang, X; Zeng, G; Zeng, X; Zhou, L; Zong, W, 2019) |
| "Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world." | 1.51 | The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice. ( Guo, F; Li, X; Liu, N; Ma, L; Sun, T; Yu, J; Zhang, X; Zheng, P; Zhou, R, 2019) |
| "Epilepsy is a common chronic disease of the central nervous system that can last for years or even decades, causing serious adverse effects on the body, mind, and psychology of patients." | 1.51 | Anti-epileptic effect of 16-O-acetyldigitoxigenin via suppressing mTOR signaling pathway. ( Qian, S; Tu, W, 2019) |
| "Protocatechuic acid (PCA) is a type of phenolic acid found in green tea and has been shown to have potent antioxidant and anti-inflammatory properties." | 1.48 | Protective Effects of Protocatechuic Acid on Seizure-Induced Neuronal Death. ( Choi, BY; Choi, HC; Hong, DK; Jeong, JH; Kho, AR; Lee, MW; Lee, SH; Lee, SY; Song, HK; Suh, SW, 2018) |
| "Uridine is a potential endogenous neuromodulator studied for several decades for its antiepileptic effect, but the results were controversial." | 1.48 | Antiepileptic effect of uridine may be caused by regulating dopamine release and receptor expression in corpus striatum. ( Bai, Y; Li, L; Wang, T; Wu, C; Zhang, L; Zhou, X, 2018) |
| "Comorbid depression is common in patients with epilepsy." | 1.48 | Different behavioral and pathological changes between epilepsy-associated depression and primary depression models. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2018) |
| "Epilepsy is associated with increased morbidity and mortality together and places a large financial burden on individuals and society." | 1.48 | Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy. ( Chen, Y; Fajol, A; Ren, B; Shi, S; Song, S, 2018) |
| " The aim of the study was to conduct an in vivo evaluation of the relationship between treatments with synthetic cannabinoid arachidonyl-2'-chloroethylamide (ACEA) alone or in combination with valproic acid (VPA) and hippocampal neurogenesis in a mouse pilocarpine model of epilepsy." | 1.46 | A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy. ( Andres-Mach, M; Dudra-Jastrzębska, M; Haratym, J; Haratym-Maj, A; Maj, M; Rola, R; Zagaja, M; Łuszczki, JJ, 2017) |
| "Epilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment." | 1.46 | DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy. ( Li, XM; Ma, XX; Ni, KM; Sun, P; Wei, X; Xu, M; Yang, CH; Yang, CR; Zhang, Y; Zhang, YJ, 2017) |
| "In the acute seizure model, both the behavioral and electrographic seizure activities were record and analyzed in rats for 90min, starting immediately after pilocarpine injection." | 1.46 | Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats. ( Chen, Y; Feng, Y; Han, X; Li, J; Liu, H; Mi, X; Wang, N; Wang, X; Zhang, Y; Zhao, T, 2017) |
| "Epilepsy is a common neurological disease, manifested in unprovoked recurrent seizures." | 1.46 | Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity. ( Bekenstein, U; Berson, A; Friedman, A; Greenberg, DS; Hanin, G; Milikovsky, DZ; Mishra, N; Sheintuch, L; Soreq, H; Zelig, D, 2017) |
| "Perinatal arterial stroke is the most frequent form of cerebral infarction in children." | 1.46 | Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model. ( Auvin, S; Baud, O; Bonnin, P; Charriaut-Marlangue, C; Dupuis, N; Enderlin, J; Leger, PL; Morin, L; Perrotte, G, 2017) |
| "Epilepsy affects 60 million people worldwide." | 1.46 | Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice. ( Benninger, F; Griffioen, K; Gross, A; Illouz, T; Madar, R; Offen, D; Okun, E; Steiner, I, 2017) |
| "Epilepsy is one of the most common and severe neurologic diseases." | 1.43 | Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models. ( Chen, G; Chen, L; Deng, W; Jiang, G; Li, J; Mi, X; Wang, N; Wang, X; Wang, Z; Zhang, Y, 2016) |
| "No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups." | 1.43 | N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model. ( Ding, J; Fan, F; Li, X; Peng, WF; Wang, X; Zhang, QQ, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| "Epilepsy is a common neurological disorder." | 1.42 | Altered Expression of Intersectin1-L in Patients with Refractory Epilepsy and in Experimental Epileptic Rats. ( Li, M; Wang, S; Wang, X; Xu, X; Yang, X; Zhang, Y, 2015) |
| "Epilepsy is a frequent neurological disorder that affects directly 0." | 1.42 | The loss of Ivy cells and the hippocampal input modulatory O-LM cells contribute to the emergence of hyperexcitability in the hippocampus. ( Orbán-Kis, K; Szabadi, T; Szilágyi, T, 2015) |
| "Temporal lobe epilepsy is often presented by medically intractable recurrent seizures due to dysfunction of temporal lobe structures, mostly the temporomesial structures." | 1.42 | Effects of TRPV1 on the hippocampal synaptic plasticity in the epileptic rat brain. ( Eslamizade, MJ; Ghadiri, T; Gorji, A; Hadjighassem, M; Modarres Mousavi, SM; Saffarzadeh, F, 2015) |
| "Sulforaphane was anticonvulsant in two acute mouse models of epilepsy and protected mice against pilocarpine-induced status epilepticus (SE)." | 1.42 | Sulforaphane is anticonvulsant and improves mitochondrial function. ( Borges, K; Carrasco-Pozo, C; Tan, KN, 2015) |
| "Epilepsy was induced in male Wistar rats via pilocarpine status epilepticus." | 1.40 | Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder. ( Griesbach, G; Jentsch, JD; Mazarati, A; Pineda, E; Sankar, R; Shin, D, 2014) |
| "Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood." | 1.40 | Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. ( Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z, 2014) |
| "EEG documented seizure activity and status epilepticus (SE) developed in 87." | 1.39 | Electrical stimulation of left anterior thalamic nucleus with high-frequency and low-intensity currents reduces the rate of pilocarpine-induced epilepsy in rats. ( Chang, FC; Jou, SB; Kao, IF; Yi, PL, 2013) |
| "In pilocarpine-treated mice, CCK was observed in dendritic spines and these were proportionally increased relative to controls, whereas the proportion of CCK-labeled terminals forming symmetric synapses was decreased." | 1.38 | Increased cholecystokinin labeling in the hippocampus of a mouse model of epilepsy maps to spines and glutamatergic terminals. ( Houser, CR; Wyeth, MS; Zhang, N, 2012) |
| "Bacopa monnieri and Bacoside-A treatment reverses epilepsy associated changes to near control suggesting that decreased GABA receptors in the cerebral cortex have an important role in epileptic occurrence; Bacopa monnieri and Bacoside-A have therapeutic application in epilepsy management." | 1.38 | Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. ( Abraham, PM; Antony, S; Balakrishnan, S; Mathew, J; Paulose, CS, 2012) |
| " We assessed, quantitatively and morphometrically, glial fibrillary acidic protein (GFAP) expression and cell densities in hippocampus in a dose-response manner 2, 4 and 8 weeks after the pilocarpine insult." | 1.38 | Glial activation in a pilocarpine rat model for epileptogenesis: a morphometric and quantitative analysis. ( Corona-Morales, AA; Escobar, A; Estrada, FS; Hernández, VS; López-Hernández, E; Solís, H; Zhang, L, 2012) |
| "Pretreatment with baicalin significantly delayed the onset of the first limbic seizures and SE, reduced the mortality rate, and attenuated the changes in the levels of lipid peroxidation, nitrite content and reduced glutathione in the hippocampus of pilocarpine-treated rats." | 1.38 | The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats. ( Gao, F; Jia, RH; Jiang, W; Jing, YY; Li, XW; Liu, YF; Meng, XD; Wang, Y; Zhao, R, 2012) |
| "Epilepsy was induced by i." | 1.38 | Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. ( Aboul Ezz, HS; Faraag, AR; Khadrawy, YA; Noor, NA, 2012) |
| "The mean frequency of seizures in the control and SHAM groups increased significantly from period 1 to period 2." | 1.38 | A strength exercise program in rats with epilepsy is protective against seizures. ( Arida, RM; Cassilhas, R; Cavalheiro, EA; de Almeida, AA; de Mello, MT; Fernandes, J; Novaes Gomes, FG; Peixinho-Pena, LF; Scorza, FA; Venancio, DP, 2012) |
| "At the spontaneous recurrent seizure period, acute stress stimulations such as cat's urine and foot electrical shock were applied to observe the behavioral changes and seizure occurrence." | 1.38 | [Effect of acute stress stimulation on the seizure induction in epileptic model rats]. ( Ju, JG; Li, ST; Li, XR; Lu, QC; Sun, Z; Wu, SJ; Zhou, P, 2012) |
| "Pilocarpine treatment significantly reduced the GAP-43 immunoreactivity in the inner molecular layer in both species, with some minor differences in the staining pattern." | 1.37 | Comparative immunohistochemistry of synaptic markers in the rodent hippocampus in pilocarpine epilepsy. ( Dobó, E; Károly, N; Mihály, A, 2011) |
| "Acquired epilepsy is associated with long-term neuronal plasticity changes in the hippocampus resulting in the expression of spontaneous recurrent seizures." | 1.37 | Characterization of spontaneous recurrent epileptiform discharges in hippocampal-entorhinal cortical slices prepared from chronic epileptic animals. ( Carter, DS; DeLorenzo, RJ; Deshpande, LS; Rafiq, A; Sombati, S, 2011) |
| "Epilepsy affects 0." | 1.37 | Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. ( Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G, 2011) |
| "Treatment with curcumin, NSO or valproate ameliorated most of the changes induced by pilocarpine and restored Na⁺, K⁺-ATPase activity in the hippocampus to control levels." | 1.37 | The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. ( Ezz, HS; Khadrawy, YA; Noor, NA, 2011) |
| "However, whether STAT3 controls astrogliosis in epilepsy is not clear." | 1.37 | Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy. ( Chen, Y; Fang, M; Lei, X; Li, Y; Wang, L; Wang, X; Xie, Y; Xu, P; Xu, Z; Xue, T; Zhang, J; Zhang, Z, 2011) |
| "Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear." | 1.37 | Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. ( Hu, XL; Liu, YY; Mei, L; Tan, GH; Xiong, ZQ; Yin, DM, 2011) |
| "At the initiation of the seizure, (14)C-acetate uptake did not change significantly." | 1.36 | Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpine. ( Gee, A; Hosoi, R; Inoue, O; Kitano, D; Kuse, K; Momosaki, S, 2010) |
| "During seizures, firing of individual neurons and interneuronal synchronization further increased." | 1.36 | Network dynamics during development of pharmacologically induced epileptic seizures in rats in vivo. ( Cymerblit-Sabba, A; Schiller, Y, 2010) |
| "Status epilepticus is a clinical emergency that can lead to the development of acquired epilepsy following neuronal injury." | 1.36 | Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. ( Carter, DS; DeLorenzo, RJ; Deshpande, LS; Nagarkatti, N, 2010) |
| "The development of epilepsy is often associated with marked changes in central nervous system cell structure and function." | 1.36 | Proteomic profiling of the epileptic dentate gyrus. ( Cao, R; Cho, HY; Choi, YS; Dziema, H; Jung, YJ; Li, A; Obrietan, K, 2010) |
| "Pilocarpine-induced SE was chosen as a model to generate chronic epileptic rats." | 1.36 | Changes in the numbers and distribution of calretinin in the epileptic rat hippocampus. ( Abuhamed, MM; Alsharafi, WA; Bo, X; Jing, L; Long, L; Zhi, S; Zhiguo, W, 2010) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 1.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "Epilepsy is a serious neurological disorder with neuronal loss and spontaneous recurrent seizures, but the neurochemical basis remains largely unclear." | 1.35 | Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. ( Chen, LW; Huang, YG; Liu, YH; Wang, L; Wei, LC, 2009) |
| "Epilepsy is a syndrome of episodic brain dysfunction characterized by recurrent unpredictable, spontaneous seizures." | 1.35 | Down-regulation of cerebellar 5-HT(2C) receptors in pilocarpine-induced epilepsy in rats: therapeutic role of Bacopa monnieri extract. ( Abraham, PM; Krishnakumar, A; Paul, J; Paulose, CS, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 1.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| " For this study, we used the same pilocarpine ramping-up dosing protocol and behavioral test battery than in a previous study in NMRI mice, thus allowing direct comparison between these two mouse strains." | 1.35 | Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. ( Bankstahl, M; Gröticke, I; Löscher, W; Müller, CJ, 2009) |
| "Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality." | 1.35 | Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus. ( Bracey, JM; Churn, SB; Kurz, JE; Low, B, 2009) |
| "ACh-induced seizure-like events could be completely blocked by the non-specific muscarinic antagonist, atropine, and were partially blocked by the muscarinic-1 receptor antagonist, pirenzepine; but were not affected by the non-specific nicotinic antagonist, mecamylamine." | 1.35 | Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. ( Behrens, CJ; Friedman, A; Gross, M; Heinemann, U; Ivens, S; Njunting, M; Soreq, H; Tolner, E; Tolner, EA; Zimmerman, G, 2008) |
| "Epilepsy is a major public health problem affecting nearly 50 million people world wide." | 1.35 | Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats. ( El Elshamy, KA; Elwakkad, AS; Sibaii, H, 2008) |
| "Drug design in epilepsy is now tackling a new target--epileptogenesis." | 1.33 | A spontaneous recurrent seizure bioassay for anti-epileptogenic molecules. ( Lyon, AP; Marone, S; Wainman, D; Weaver, DF, 2005) |
| "Among the causes for sudden death in epilepsy, cardiac dysfunction has been an area of interest." | 1.33 | [Analysis of cardiac parameters in animals with epilepsy: possible cause of sudden death?]. ( Arida, RM; Cavalheiro, EA; Colugnati, DB; Cysneiros, RM; de Albuquerque, M; Gomes, PA; Scorza, FA, 2005) |
| " In contrast, in human neocortical preparations obtained from epilepsy surgery, in approximately 20% of the slices spontaneous epileptiform activity appeared with this bicuculline dosage without SDs." | 1.32 | Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue. ( Hagemann, G; Koch, UR; Köhling, R; Redecker, C; Speckmann, EJ; Straub, H, 2003) |
| " In addition, long-term administration of high-dose topiramate in the normal developing rat brain does not appear to impair cognitive performance." | 1.31 | Effect of topiramate following recurrent and prolonged seizures during early development. ( Cha, BH; Holmes, GL; Hu, Y; Liu, X; Silveira, DC, 2002) |
| "The course of untreated epilepsy is not well established." | 1.30 | The course of untreated seizures in the pilocarpine model of epilepsy. ( Arida, RM; Cavalheiro, EA; Peres, CA; Scorza, FA, 1999) |
| "Pilocarpine-treated rats were studied because they not only have seizures and increased BDNF expression in granule cells, but they also have reorganization of granule cell "mossy fiber" axons." | 1.30 | Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus. ( Goodman, JH; Scharfman, HE; Sollas, AL, 1999) |
| "When pilocarpine was administered to this group of rats, there were further selective, significant, transient increases in the extracellular levels of aspartate (31%) and glutamate (18%) which preceded the onset of seizures." | 1.29 | Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures. ( Chapman, AG; Meldrum, BS; Millan, MH, 1993) |
| "Here we evaluated whether spontaneous seizures would lead to similar impairments." | 1.29 | Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures. ( Covolan, L; Mello, LE, 1996) |
| " A narrow bell-shaped dose-response relationship was found." | 1.28 | ACTH: a structure-activity study on pilocarpine-induced epilepsy. ( Croiset, G; De Wied, D, 1992) |
| "Pretreatment with reserpine had no effect on either the time to onset or duration of maximal dentate activation." | 1.28 | Cholinergic and adrenergic agents modify the initiation and termination of epileptic discharges in the dentate gyrus. ( Lothman, EW; Stringer, JL, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (1.15) | 18.7374 |
| 1990's | 43 (8.25) | 18.2507 |
| 2000's | 134 (25.72) | 29.6817 |
| 2010's | 247 (47.41) | 24.3611 |
| 2020's | 91 (17.47) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, J | 2 |
| Wang, L | 9 |
| Huang, Y | 4 |
| Wu, Q | 1 |
| Luo, X | 1 |
| Li, Y | 7 |
| Ren, S | 1 |
| Wu, G | 1 |
| Wang, Y | 8 |
| Yuan, J | 3 |
| Yu, X | 4 |
| Liu, X | 12 |
| Tan, C | 1 |
| Chen, Y | 11 |
| Xu, T | 3 |
| Righes Marafiga, J | 1 |
| Vendramin Pasquetti, M | 1 |
| Calcagnotto, ME | 2 |
| Lee, WJ | 1 |
| Moon, J | 4 |
| Lim, JA | 3 |
| Jeon, D | 5 |
| Yoo, JS | 2 |
| Park, DK | 2 |
| Han, D | 1 |
| Lee, ST | 5 |
| Jung, KH | 5 |
| Park, KI | 3 |
| Lee, SK | 5 |
| Chu, K | 5 |
| Wang, P | 3 |
| Ma, K | 1 |
| Yang, L | 3 |
| Zhang, G | 2 |
| Ye, M | 1 |
| Wang, S | 3 |
| Wei, S | 1 |
| Chen, Z | 5 |
| Gu, J | 2 |
| Zhang, L | 10 |
| Niu, J | 3 |
| Tao, S | 1 |
| Harb, IA | 1 |
| Ashour, H | 1 |
| Mostafa, A | 1 |
| El Hanbuli, HM | 1 |
| Nadwa, EH | 1 |
| Javed, L | 1 |
| Hanif, F | 1 |
| Malhi, SM | 2 |
| Zaman, U | 1 |
| Jahan, N | 1 |
| Amir, Q | 1 |
| Javed, A | 1 |
| Malik, AB | 1 |
| Abrar, H | 1 |
| Mátyás, A | 2 |
| Borbély, E | 1 |
| Mihály, A | 3 |
| Dyomina, AV | 4 |
| Kovalenko, AA | 3 |
| Zakharova, MV | 2 |
| Postnikova, TY | 2 |
| Griflyuk, AV | 2 |
| Smolensky, IV | 3 |
| Antonova, IV | 1 |
| Zaitsev, AV | 6 |
| Pascoal, VDB | 2 |
| Marchesini, RB | 1 |
| Athié, MCP | 1 |
| Matos, AHB | 1 |
| Conte, FF | 1 |
| Pereira, TC | 1 |
| Secolin, R | 1 |
| Gilioli, R | 1 |
| Malheiros, JM | 3 |
| Polli, RS | 2 |
| Tannús, A | 3 |
| Covolan, L | 6 |
| Pascoal, LB | 1 |
| Vieira, AS | 1 |
| Cavalheiro, EA | 45 |
| Cendes, F | 1 |
| Lopes-Cendes, I | 2 |
| Qi, R | 1 |
| Wang, M | 2 |
| Zhong, Q | 1 |
| Yang, X | 3 |
| Huang, B | 1 |
| Yang, Z | 6 |
| Zhang, C | 3 |
| Geng, X | 1 |
| Luo, C | 1 |
| Wang, W | 6 |
| Li, J | 9 |
| Yu, H | 2 |
| Wei, J | 1 |
| Bae, S | 1 |
| Lim, HK | 1 |
| Jeong, Y | 1 |
| Kim, SG | 1 |
| Park, SM | 1 |
| Shon, YM | 2 |
| Suh, M | 1 |
| Schwarz, AP | 1 |
| Zubareva, OE | 2 |
| Bera, A | 1 |
| Srivastava, A | 1 |
| Dubey, V | 1 |
| Dixit, AB | 1 |
| Tripathi, M | 1 |
| Sharma, MC | 1 |
| Lalwani, S | 1 |
| Chandra, PS | 1 |
| Banerjee, J | 1 |
| Tong, F | 1 |
| Liu, L | 4 |
| Su, Z | 2 |
| Ding, J | 5 |
| Wang, Q | 4 |
| Wang, X | 25 |
| Seo, GY | 1 |
| Neal, ES | 2 |
| Han, F | 1 |
| Vidovic, D | 1 |
| Nooru-Mohamed, F | 1 |
| Dienel, GA | 1 |
| Sullivan, MA | 1 |
| Borges, K | 8 |
| Shehata, NI | 1 |
| Abdelsamad, MA | 1 |
| Amin, HAA | 1 |
| Sadik, NAH | 1 |
| Shaheen, AA | 1 |
| Trindade-Filho, EM | 2 |
| Pai, JD | 1 |
| Castro, DN | 1 |
| Silva, ATMD | 1 |
| Costa, AF | 1 |
| Vieira, JSS | 1 |
| Santos, SDBD | 1 |
| Félix, VB | 1 |
| Leão, SABF | 1 |
| Zambrano, LI | 1 |
| Saldanha-Filho, AJM | 1 |
| Carvalho, EGA | 1 |
| Cavalcante, JBN | 1 |
| Quintella, GB | 1 |
| Lino, ATS | 1 |
| Costa, MV | 1 |
| Lima, JA | 1 |
| Tavares, MMA | 1 |
| de Melo, MR | 1 |
| Mousinho, KC | 1 |
| Biase, CLCL | 1 |
| Leite, ML | 1 |
| Costa, PJMS | 1 |
| Becker, EL | 1 |
| Moura, IMFB | 1 |
| Silva, JCD | 1 |
| Abdelbasset, WK | 1 |
| Jasim, SA | 1 |
| Rudiansyah, M | 1 |
| Huldani, H | 1 |
| Margiana, R | 1 |
| Jalil, AT | 1 |
| Mohammad, HJ | 1 |
| Ridha, HS | 1 |
| Yasin, G | 1 |
| Zhang, J | 7 |
| Qiao, N | 2 |
| Wang, J | 11 |
| Li, B | 1 |
| Wan, D | 1 |
| Ren, J | 2 |
| Huang, H | 6 |
| Chen, L | 10 |
| Su, X | 1 |
| Huang, Q | 4 |
| Sun, T | 3 |
| Wen, F | 1 |
| Tan, ZG | 1 |
| Xiang, J | 1 |
| Mikkelsen, JD | 1 |
| Aripaka, SS | 1 |
| Bascuñana, P | 3 |
| Bankstahl, M | 2 |
| Bankstahl, JP | 1 |
| Pazarlar, BA | 1 |
| Komori, R | 1 |
| Matsuo, T | 1 |
| Yokota-Nakatsuma, A | 1 |
| Hashimoto, R | 1 |
| Kubo, S | 1 |
| Kozawa, C | 1 |
| Kono, T | 1 |
| Ishihara, Y | 1 |
| Itoh, K | 1 |
| Araújo Delmondes, G | 1 |
| Pereira Lopes, MJ | 1 |
| Araújo, IM | 1 |
| de Sousa Borges, A | 1 |
| Batista, PR | 1 |
| Melo Coutinho, HD | 1 |
| Alencar de Menezes, IR | 1 |
| Barbosa-Filho, JM | 1 |
| Bezerra Felipe, CF | 1 |
| Kerntopf, MR | 1 |
| Yue, J | 1 |
| Xu, R | 1 |
| Yin, C | 1 |
| Yang, H | 3 |
| Zhao, D | 2 |
| Sun, Y | 2 |
| Peng, Z | 2 |
| Wei, X | 2 |
| Zhang, N | 3 |
| Huang, CS | 2 |
| Wallner, M | 1 |
| Mody, I | 2 |
| Houser, CR | 4 |
| Oliveira, MET | 1 |
| Paulino, GVB | 1 |
| Dos Santos Júnior, ED | 1 |
| da Silva Oliveira, FA | 1 |
| Melo, VMM | 1 |
| Ursulino, JS | 1 |
| de Aquino, TM | 1 |
| Shetty, AK | 2 |
| Landell, MF | 1 |
| Gitaí, DLG | 2 |
| Liu, Z | 2 |
| Zeng, C | 1 |
| Xu, Y | 4 |
| He, L | 1 |
| Fang, Q | 1 |
| Kumar, H | 1 |
| Katyal, J | 1 |
| Joshi, D | 1 |
| Gupta, YK | 1 |
| Arshad, MN | 1 |
| Oppenheimer, S | 1 |
| Jeong, J | 1 |
| Buyukdemirtas, B | 1 |
| Naegele, JR | 1 |
| Singh, S | 1 |
| Singh, TG | 1 |
| Guo, A | 1 |
| Zhang, H | 12 |
| Li, H | 1 |
| Chiu, A | 1 |
| García-Rodríguez, C | 1 |
| Lagos, CF | 1 |
| Sáez, JC | 1 |
| Lau, CG | 1 |
| Shishmanova-Doseva, M | 1 |
| Georgieva, K | 1 |
| Uzunova, Y | 1 |
| Ioanidu, L | 1 |
| Atanasova, M | 2 |
| Nenchovska, Z | 1 |
| Tchekalarova, J | 1 |
| George, MY | 3 |
| El-Derany, MO | 3 |
| Ahmed, Y | 3 |
| Zaher, M | 3 |
| Ibrahim, C | 3 |
| Waleed, H | 3 |
| Khaled, H | 3 |
| Khaled, G | 3 |
| Saleh, A | 3 |
| Alshafei, H | 3 |
| Alshafei, R | 3 |
| Ahmed, N | 3 |
| Ezz, S | 3 |
| Ashraf, N | 3 |
| Ibrahim, SS | 3 |
| Li, D | 5 |
| Tuo, J | 3 |
| Zhang, F | 4 |
| Tai, Z | 4 |
| Qiu, X | 4 |
| Yang, J | 9 |
| Luo, Z | 3 |
| Xu, Z | 8 |
| Adassi, MB | 2 |
| Ngoupaye, GT | 2 |
| Yassi, FB | 2 |
| Foutsop, AF | 2 |
| Kom, TD | 2 |
| Ngo Bum, E | 2 |
| Vizuete, AFK | 2 |
| Leal, MB | 1 |
| Moreira, AP | 1 |
| Seady, M | 1 |
| Taday, J | 1 |
| Gonçalves, CA | 2 |
| de Labra, C | 1 |
| Cudeiro, J | 2 |
| Rivadulla, C | 2 |
| Xu, K | 4 |
| Xie, P | 2 |
| Deng, J | 2 |
| Tang, C | 2 |
| Guan, Y | 2 |
| Zhou, J | 4 |
| Li, T | 3 |
| Liang, X | 1 |
| Jing, B | 1 |
| Gao, JH | 1 |
| Luan, G | 3 |
| Liu, Y | 8 |
| Ai, M | 1 |
| Xia, D | 1 |
| Chen, H | 4 |
| Pang, R | 1 |
| Mei, R | 1 |
| Zhong, L | 1 |
| Sharma, S | 3 |
| Rana, AK | 3 |
| Rahmatkar, SN | 1 |
| Patial, V | 2 |
| Singh, D | 3 |
| Lévesque, M | 3 |
| Macey-Dare, ADB | 1 |
| Salami, P | 1 |
| Avoli, M | 9 |
| Suchomelova, L | 2 |
| Thompson, KW | 2 |
| Baldwin, RA | 2 |
| Niquet, J | 3 |
| Wasterlain, CG | 4 |
| Liu, S | 1 |
| Xiong, Z | 1 |
| Zhang, B | 3 |
| He, B | 2 |
| Zhai, F | 1 |
| Sun, S | 2 |
| Wang, H | 3 |
| El-Nahas, AE | 1 |
| Elbedaiwy, HM | 1 |
| Masoud, IM | 1 |
| Aly, RG | 1 |
| Helmy, MW | 1 |
| El-Kamel, AH | 1 |
| Diespirov, GP | 1 |
| Gao, F | 2 |
| Chen, R | 1 |
| Li, S | 3 |
| Li, A | 4 |
| Bai, B | 1 |
| Mi, R | 1 |
| Xue, G | 1 |
| Luo, Y | 2 |
| Hernández-Martín, N | 1 |
| Gomez, F | 1 |
| Silván, Á | 1 |
| Rosa, RF | 1 |
| Delgado, M | 2 |
| Pozo, MÁ | 2 |
| García-García, L | 2 |
| Tewari, BP | 1 |
| Harshad, PA | 1 |
| Singh, M | 1 |
| Joshi, NB | 1 |
| Joshi, PG | 1 |
| Balaha, MF | 1 |
| Alamer, AA | 1 |
| Abdel-Kader, MS | 1 |
| Alharthy, KM | 1 |
| Szep, D | 1 |
| Dittrich, B | 1 |
| Gorbe, A | 1 |
| Szentpeteri, JL | 1 |
| Aly, N | 1 |
| Jin, M | 1 |
| Budan, F | 1 |
| Sik, A | 1 |
| Tian, S | 1 |
| Qu, Z | 3 |
| Cao, H | 1 |
| Niu, X | 1 |
| Qiao, Q | 2 |
| Jia, L | 2 |
| de Melo, IS | 2 |
| Sabino-Silva, R | 2 |
| Costa, MA | 2 |
| Vaz, ER | 1 |
| Anselmo-E-Silva, CI | 1 |
| de Paula Soares Mendonça, T | 1 |
| Oliveira, KB | 1 |
| de Souza, FMA | 2 |
| Dos Santos, YMO | 1 |
| Pacheco, ALD | 2 |
| Freitas-Santos, J | 2 |
| Caixeta, DC | 1 |
| Goulart, LR | 1 |
| de Castro, OW | 2 |
| Burke, CT | 1 |
| Vitko, I | 1 |
| Straub, J | 1 |
| Nylund, EO | 1 |
| Gawda, A | 1 |
| Blair, K | 1 |
| Sullivan, KA | 1 |
| Ergun, L | 1 |
| Ottolini, M | 1 |
| Patel, MK | 1 |
| Perez-Reyes, E | 1 |
| Wu, Y | 3 |
| Yang, K | 2 |
| Yan, L | 1 |
| Feng, L | 5 |
| Shao, M | 1 |
| Santhakumar, V | 1 |
| Yu, J | 4 |
| Wu, ZS | 1 |
| Huang, WL | 1 |
| Gong, SJ | 1 |
| Dong, YY | 1 |
| Chu, X | 1 |
| Cui, S | 1 |
| Kong, QX | 1 |
| Gelfuso, EA | 1 |
| Reis, SL | 1 |
| Pereira, AMS | 1 |
| Aguiar, DSR | 1 |
| Beleboni, RO | 1 |
| Foresti, ML | 1 |
| Arisi, GM | 1 |
| Campbell, JJ | 1 |
| Mello, LE | 12 |
| Ying, C | 1 |
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| Yanxia, L | 1 |
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| Lili, C | 1 |
| Yuan, P | 1 |
| Han, W | 2 |
| Xie, L | 3 |
| Cheng, L | 3 |
| Chen, J | 3 |
| Jiang, L | 4 |
| Wyeth, M | 1 |
| Nagendran, M | 1 |
| Buckmaster, PS | 1 |
| Yang, P | 1 |
| Qin, Y | 1 |
| Zhu, Y | 1 |
| Li, F | 1 |
| Xia, SS | 1 |
| Zhou, B | 1 |
| Lu, J | 1 |
| Li, L | 2 |
| Huang, HY | 1 |
| Park, KM | 1 |
| Kim, JE | 6 |
| Choi, IY | 1 |
| Cho, KO | 4 |
| Hu, H | 1 |
| Zhu, T | 1 |
| Gong, L | 1 |
| Zhao, Y | 1 |
| Shao, Y | 1 |
| Sun, Z | 2 |
| Ling, Y | 1 |
| Tao, Y | 1 |
| Ying, Y | 1 |
| Lan, C | 1 |
| Xie, Y | 4 |
| Jiang, P | 1 |
| Yang, Y | 5 |
| Zhu, J | 4 |
| Fu, P | 2 |
| Yuan, Q | 1 |
| Wu, X | 2 |
| Du, Z | 1 |
| Li, Z | 3 |
| Lv, K | 1 |
| Hu, J | 2 |
| Zhou, X | 3 |
| Chen, Q | 3 |
| Peng, Y | 1 |
| Zeng, J | 1 |
| Feng, Z | 1 |
| Lajkó, N | 1 |
| Kata, D | 1 |
| Szabó, M | 1 |
| Dulka, K | 1 |
| Földesi, I | 1 |
| Fülöp, F | 1 |
| Gulya, K | 1 |
| Vécsei, L | 1 |
| Tang, W | 1 |
| He, X | 1 |
| Liu, D | 1 |
| Xiao, B | 3 |
| Sharma, M | 1 |
| Joshi, R | 1 |
| Swarnkar, MK | 1 |
| Acharya, V | 1 |
| Hampel, P | 1 |
| Römermann, K | 1 |
| Gailus, B | 1 |
| Johne, M | 1 |
| Gericke, B | 1 |
| Kaczmarek, E | 1 |
| Löscher, W | 6 |
| Schmidt, S | 1 |
| Pothmann, L | 2 |
| Müller-Komorowska, D | 1 |
| Opitz, T | 3 |
| Soares da Silva, P | 1 |
| Beck, H | 11 |
| Nicácio, DCSP | 1 |
| Oliveira Dos Santos, YM | 1 |
| Cavalcante, CMB | 1 |
| Gomes Dos Santos Neto, J | 1 |
| Torres de Miranda, C | 1 |
| Borbely, AU | 1 |
| Duzzioni, M | 1 |
| Geng, J | 2 |
| Zhao, H | 1 |
| Gao, Y | 2 |
| Hou, X | 1 |
| Yang, F | 3 |
| Ma, N | 1 |
| Lin, S | 1 |
| Lin, Y | 3 |
| Yan, X | 1 |
| Zheng, M | 1 |
| Lee, TH | 1 |
| Zhou, XZ | 1 |
| Lu, KP | 1 |
| Liu, H | 3 |
| Nisar, U | 1 |
| Shahid, M | 1 |
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| Shaheen, F | 1 |
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| Lybrand, ZR | 2 |
| Goswami, S | 1 |
| Jarzabek, V | 1 |
| Merlock, N | 1 |
| Aktar, M | 2 |
| Smith, C | 1 |
| Varma, P | 1 |
| Ge, S | 1 |
| Hsieh, J | 3 |
| Han, J | 1 |
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| Bichler, E | 1 |
| Benveniste, M | 1 |
| Mihály, I | 1 |
| Molnár, T | 1 |
| Berki, ÁJ | 1 |
| Bod, RB | 1 |
| Orbán-Kis, K | 2 |
| Gáll, Z | 1 |
| Szilágyi, T | 2 |
| Sano, F | 1 |
| Shigetomi, E | 1 |
| Shinozaki, Y | 1 |
| Tsuzukiyama, H | 1 |
| Saito, K | 1 |
| Mikoshiba, K | 1 |
| Horiuchi, H | 1 |
| Cheung, DL | 1 |
| Nabekura, J | 1 |
| Sugita, K | 1 |
| Aihara, M | 1 |
| Koizumi, S | 1 |
| Zhang, Y | 15 |
| Cheng, W | 1 |
| Sadeghi, L | 1 |
| Rizvanov, AA | 1 |
| Dabirmanesh, B | 1 |
| Salafutdinov, II | 1 |
| Sayyah, M | 2 |
| Shojaei, A | 1 |
| Zahiri, J | 1 |
| Mirnajafi-Zadeh, J | 1 |
| Khorsand, B | 1 |
| Khajeh, K | 1 |
| Fathollahi, Y | 1 |
| Bocca Nejm, M | 1 |
| Victorino, DB | 1 |
| Guimarães-Marques, MJ | 1 |
| Scorza, CA | 6 |
| Finsterer, J | 1 |
| Scorza, FA | 27 |
| Cysneiros, RM | 10 |
| Al-Rafiah, AR | 1 |
| Mehdar, KM | 1 |
| Shiono, S | 1 |
| Sun, H | 3 |
| Batabyal, T | 1 |
| Labuz, A | 1 |
| Williamson, J | 1 |
| Kapur, J | 1 |
| Joshi, S | 1 |
| McDonald, TS | 3 |
| Brulet, R | 2 |
| Karyakin, VB | 1 |
| Vasil'ev, DS | 1 |
| Zhuravin, IA | 1 |
| Magazanik, LG | 1 |
| Watanabe, S | 1 |
| Saito, M | 1 |
| Soma, M | 1 |
| Miyaoka, H | 1 |
| Takahashi, M | 1 |
| Andres-Mach, M | 1 |
| Zagaja, M | 1 |
| Haratym-Maj, A | 1 |
| Rola, R | 1 |
| Maj, M | 1 |
| Haratym, J | 1 |
| Dudra-Jastrzębska, M | 1 |
| Łuszczki, JJ | 1 |
| Ma, L | 3 |
| Li, R | 3 |
| Ou, S | 2 |
| Rocha, AKAA | 1 |
| de Lima, E | 3 |
| Amaral, F | 1 |
| Peres, R | 2 |
| Cipolla-Neto, J | 2 |
| Amado, D | 9 |
| Xu, M | 1 |
| Sun, P | 1 |
| Yang, CH | 2 |
| Ma, XX | 1 |
| Yang, CR | 1 |
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| Li, XM | 3 |
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| Hao, F | 1 |
| Yan, ZR | 1 |
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| Liu, XW | 2 |
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| Friedman, A | 3 |
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| Shin, D | 4 |
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| Mazarati, A | 3 |
| Amorim, RP | 1 |
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| da Silva Fernandes, MJ | 3 |
| Lösing, P | 1 |
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| Zhou, L | 5 |
| Luo, W | 1 |
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| Macedo, CE | 1 |
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| Aarão, MC | 1 |
| Miranda, MF | 2 |
| Rodrigues, AM | 3 |
| de Almeida, AG | 2 |
| Longo, BM | 4 |
| Yamasaki, T | 1 |
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| Mori, W | 1 |
| Wakizaka, H | 1 |
| Nengaki, N | 1 |
| Hatori, A | 1 |
| Zhang, MR | 1 |
| Rehberg, M | 1 |
| Kirschstein, T | 3 |
| Guli, X | 1 |
| Müller, S | 1 |
| Rohde, M | 1 |
| Franz, D | 1 |
| Tokay, T | 2 |
| Köhling, R | 5 |
| Oya, M | 1 |
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| Anas, ARJ | 1 |
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| Oliveira, CV | 3 |
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| Canzian, JM | 1 |
| Duarte, MMMF | 1 |
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| Furian, AF | 3 |
| Oliveira, MS | 4 |
| Suemaru, K | 1 |
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| Tanaka, A | 1 |
| Araki, H | 1 |
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| Watanabe, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| Searching for Exosomal microRNAs and Cellular Biomarkers and Mechanisms Underlying the Differences Between Panic Disorder Patients Who Are Responders and Non-responders to Cognitive Behavior Therapy[NCT04029740] | 80 participants (Anticipated) | Interventional | 2019-03-24 | Recruiting | |||
| Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury[NCT04945213] | Phase 3 | 312 participants (Anticipated) | Interventional | 2023-01-10 | Recruiting | ||
| A Phase 2A/2B Placebo-controlled Randomised Clinical Trial to Test the Ability of Triheptanoin to Protect Primary Airway Epithelial Cells Obtained From Participants With Ataxia-telangiectasia Against Death Induced by Glucose Deprivation[NCT04513002] | Phase 2 | 30 participants (Actual) | Interventional | 2022-03-15 | Completed | ||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for pilocarpine and Aura
| Article | Year |
|---|---|
Evolution of interictal activity in models of mesial temporal lobe epilepsy.
Topics: Animals; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pil | 2023 |
The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity.
Topics: Action Potentials; Animals; Cyclic AMP Response Element-Binding Protein; Epilepsy; Gene Expression R | 2016 |
High-frequency oscillations and mesial temporal lobe epilepsy.
Topics: Animals; Brain Waves; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pilocarpine | 2018 |
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; | 2010 |
Hippocampal MRI and other structural biomarkers: experimental approach to epileptogenesis.
Topics: Animals; Biomarkers; Diffusion Magnetic Resonance Imaging; Epilepsy; Hippocampus; Magnetic Resonance | 2011 |
Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Electric Stimulation; Electrophysiology; Entorhinal Cor | 2002 |
Neuropeptide Y in the recurrent mossy fiber pathway.
Topics: Animals; Epilepsy; Humans; Mice; Mossy Fibers, Hippocampal; Neuronal Plasticity; Neuropeptide Y; Pil | 2007 |
Recurrent seizures in the developing brain are harmful.
Topics: Adult; Animals; Brain; Brain Injuries; Child; Disease Models, Animal; Entorhinal Cortex; Epilepsy; H | 1997 |
Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Disease Su | 1988 |
512 other studies available for pilocarpine and Aura
| Article | Year |
|---|---|
Cognitive Impairment and Mossy Fiber Sprouting in a Rat Model of Drug-resistant Epilepsy Induced by Lithium-pilocarpine.
Topics: Animals; Cognitive Dysfunction; Epilepsy; Humans; Lithium; Mossy Fibers, Hippocampal; Pilocarpine; R | 2021 |
Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.
Topics: Animals; Carrier Proteins; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epilepsy; E | 2021 |
In vitro Oscillation Patterns Throughout the Hippocampal Formation in a Rodent Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Pilocarpine; Rats; | 2021 |
Proteins related to ictogenesis and seizure clustering in chronic epilepsy.
Topics: Animals; Cerebral Cortex; Cluster Analysis; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mic | 2021 |
Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study.
Topics: Animals; Cell Differentiation; Demyelinating Diseases; Disease Models, Animal; Epilepsy; Hippocampus | 2021 |
Cardioprotective effects of amiodarone in a rat model of epilepsy-induced cardiac dysfunction.
Topics: Adjuvants, Immunologic; Amiodarone; Animals; Anti-Arrhythmia Agents; Biomarkers; Epilepsy; Glutathio | 2022 |
Diclofenac sodium enhances the antiepileptic effect of levetiracetam in pilocarpine induced epileptic mice model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Behavior, Animal; Convulsants; Di | 2021 |
Hippocampal Sclerosis in Pilocarpine Epilepsy: Survival of Peptide-Containing Neurons and Learning and Memory Disturbances in the Adult NMRI Strain Mouse.
Topics: Aging; Animals; Calbindin 2; Cell Proliferation; Cell Survival; Densitometry; Epilepsy; Hippocampus; | 2021 |
MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Hippocampus; Lithium; Male; Neurons; Ne | 2022 |
Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Interleukin-1beta; | 2023 |
Chronic vagus nerve stimulation (VNS) altered IL-6, IL-1β, CXCL-1 and IL-13 levels in the hippocampus of rats with LiCl-pilocarpine-induced epilepsy.
Topics: Animals; Chemokine CXCL1; Epilepsy; Hippocampus; Interleukin-13; Interleukin-1beta; Interleukin-6; L | 2022 |
Deep brain stimulation of the anterior nuclei of the thalamus can alleviate seizure severity and induce hippocampal GABAergic neuronal changes in a pilocarpine-induced epileptic mouse brain.
Topics: Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Epilepsy; Hippocampus; Mice; Pilocarpine; | 2022 |
Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Brain; Epilepsy; Epilepsy, Temporal Lobe; Gene Expression; Hippocampus; Humans; Lithium; Pi | 2022 |
Altered hippocampal expression and function of cytosolic phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE).
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Group IV Phospholipases A2; Hipp | 2022 |
CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy.
Topics: Animals; Dentate Gyrus; Epilepsy; Epilepsy, Temporal Lobe; Humans; Mossy Fibers, Hippocampal; Piloca | 2022 |
Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Glutamate-Ammonia Ligase; Glycogen; Mice; Pilocarp | 2022 |
Ameliorating effect of ketogenic diet on acute status epilepticus: Insights into biochemical and histological changes in rat hippocampus.
Topics: Animals; Diet, Ketogenic; Epilepsy; Female; Hippocampus; Pilocarpine; Rats; Status Epilepticus | 2022 |
Dopamine depletion in wistar rats with epilepsy.
Topics: Animals; Dopamine; Epilepsy; Male; Muscarinic Agonists; Oxidopamine; Pilocarpine; Rats; Rats, Wistar | 2022 |
Treatment of pilocarpine-induced epileptic seizures in adult male mice.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Epilepsy; Humans; Male; Mice; Pilocarpine; Pioglit | 2022 |
Nuclear translocation of GluA2/ GAPDH promotes neurotoxicity after pilocarpine-induced epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Glyceraldehyde-3-Phosphate Dehydrogenases; Hippocampus; P | 2022 |
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the hippocampus of lithium-pilocarpine-induced acute epileptic rats.
Topics: Animals; Epilepsy; Hippocampus; Lithium; Matrix Metalloproteinases; Pilocarpine; Rats; Seizures; Tis | 2022 |
Cu-Zn SOD suppresses epilepsy in pilocarpine-treated rats and alters SCN2A/Nrf2/HO-1 expression
Topics: Animals; Epilepsy; Humans; NAV1.2 Voltage-Gated Sodium Channel; Neuroblastoma; NF-E2-Related Factor | 2022 |
Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain.
Topics: Animals; Brain; Epilepsy; Female; Hippocampus; Lithium; Membrane Glycoproteins; Nerve Tissue Protein | 2022 |
Regulation of Inflammation-Related Genes through
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Inflammation; Levetiracetam; Mice; Piloc | 2022 |
Possible mechanisms involved in the neuroprotective effect of Trans,trans-farnesol on pilocarpine-induced seizures in mice.
Topics: Animals; Dopamine; Epilepsy; Farnesol; Hippocampus; Mice; Neuroprotective Agents; Norepinephrine; Pi | 2022 |
Negative effects of brain regulatory T cells depletion on epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Pilo | 2022 |
Virally-induced expression of GABA
Topics: Animals; Dentate Gyrus; Epilepsy; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Neurosteroids; | 2022 |
Multi-omic Analysis of the Gut Microbiome in Rats with Lithium-Pilocarpine-Induced Temporal Lobe Epilepsy.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Gastrointestinal Microbiome; Lithium; Pilocarpine; Rats | 2022 |
Dynorphin/KOR inhibits neuronal autophagy by activating mTOR signaling pathway to prevent acute seizure epilepsy.
Topics: Animals; Anticonvulsants; Apoptosis; Autophagy; Biotin; Dynorphins; Epilepsy; Green Fluorescent Prot | 2022 |
Effect of morphine administration after status epilepticus on epileptogenesis in rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Lithium; Morphine; Naloxone; Pilocarpine; Rats; Seizures; | 2022 |
Hippocampal transplants of fetal GABAergic progenitors regulate adult neurogenesis in mice with temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Mice; Neurogenesis; Pilocarp | 2022 |
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetraz | 2023 |
Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy.
Topics: Animals; Connexins; Epilepsy; Epilepsy, Temporal Lobe; Mice; Neuroinflammatory Diseases; Pilocarpine | 2022 |
Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences.
Topics: Animals; Disease Models, Animal; Endurance Training; Epilepsy; Hippocampus; Humans; Pilocarpine; Rat | 2022 |
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway.
Topics: AMP-Activated Protein Kinases; Animals; Epilepsy; Lithium; Microglia; Oxidative Stress; Pilocarpine; | 2023 |
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway.
Topics: AMP-Activated Protein Kinases; Animals; Epilepsy; Lithium; Microglia; Oxidative Stress; Pilocarpine; | 2023 |
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway.
Topics: AMP-Activated Protein Kinases; Animals; Epilepsy; Lithium; Microglia; Oxidative Stress; Pilocarpine; | 2023 |
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway.
Topics: AMP-Activated Protein Kinases; Animals; Epilepsy; Lithium; Microglia; Oxidative Stress; Pilocarpine; | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Arundic acid (ONO-2506) downregulates neuroinflammation and astrocyte dysfunction after status epilepticus in young rats induced by Li-pilocarpine.
Topics: Animals; Astrocytes; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; Neuroinflammatory Disea | 2023 |
Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model.
Topics: Animals; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Magnetic Fields; Piloca | 2023 |
Long-term ANT-DBS effects in pilocarpine-induced epileptic rats: A combined 9.4T MRI and histological study.
Topics: Adult; Animals; Deep Brain Stimulation; Epilepsy; Gliosis; Hippocampus; Humans; Magnetic Resonance I | 2023 |
Upregulation of SLITRK5 in patients with epilepsy and in a rat model.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Neocortex; Pilocarp | 2023 |
Protective effect of Nardostachys jatamansi extract against lithium-pilocarpine-induced spontaneous recurrent seizures and associated cardiac irregularities in a rat model.
Topics: Animals; Epilepsy; Lithium; Molecular Docking Simulation; Nardostachys; Pilocarpine; Rats; Seizures; | 2023 |
Interictal aggression in rats with chronic seizures after an early life episode of status epilepticus.
Topics: Aggression; Animals; Epilepsy; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epil | 2023 |
Deep brain stimulation suppresses epileptic seizures in rats via inhibition of adenosine kinase and activation of adenosine A1 receptors.
Topics: Adenosine Kinase; Animals; Disease Progression; Epilepsy; Male; Pilocarpine; Rats; Rats, Sprague-Daw | 2023 |
Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Mice; Pilocarpine; Up-Regulation | 2023 |
Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy.
Topics: Animals; Berberine; Brain; Epilepsy; Hyaluronic Acid; Nanoparticles; Pilocarpine; Rats; Zein | 2023 |
Alterations in the Properties of the Rat Hippocampus Glutamatergic System in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Pilocarpin | 2023 |
(+)-Borneol exerts neuroprotective effects via suppressing the NF-κB pathway in the pilocarpine-induced epileptogenesis rat model.
Topics: Animals; Cyclooxygenase 2; Epilepsy; Neuroinflammatory Diseases; Neuroprotective Agents; NF-kappa B; | 2023 |
Phosphoglycerate kinase (PGK) 1 succinylation modulates epileptic seizures and the blood-brain barrier.
Topics: Adenosine Triphosphate; Angiostatins; Animals; Blood-Brain Barrier; Epilepsy; Lithium; Phosphoglycer | 2023 |
A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Flufen | 2023 |
Pilocarpine-induced acute seizure causes rapid area-specific astrogliosis and alters purinergic signaling in rat hippocampus.
Topics: Animals; Astrocytes; Calcium; Epilepsy; Gliosis; Hippocampus; Pilocarpine; Rats; Seizures | 2023 |
Ameliorative Potential of (-) Pseudosemiglabrin in Mice with Pilocarpine-Induced Epilepsy: Antioxidant, Anti-Inflammatory, Anti-Apoptotic, and Neurotransmission Modulation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; bcl-2-Associated X Protein; Epilepsy; Mice; NF-E2-R | 2023 |
A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy; Larva; Pentylenetetrazole; | 2023 |
The neuroprotective effect of Dl-3-n-butylphthalide in epileptic rats via inhibiting endoplasmic reticulum stress.
Topics: Animals; Endoplasmic Reticulum Stress; Epilepsy; Neuroprotective Agents; Pilocarpine; Rats; Rats, Sp | 2023 |
Refinement of the Barnes and Morris water maze protocols improves characterization of spatial cognitive deficits in the lithium-pilocarpine rat model of epilepsy.
Topics: Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe | 2023 |
N-Formyl-Methionyl-Leucyl-Phenylalanine Plays a Neuroprotective and Anticonvulsant Role in Status Epilepticus Model.
Topics: Animals; Anticonvulsants; Epilepsy; Male; N-Formylmethionine Leucyl-Phenylalanine; Peptides; Pilocar | 2023 |
EpiPro, a Novel, Synthetic, Activity-Regulated Promoter That Targets Hyperactive Neurons in Epilepsy for Gene Therapy Applications.
Topics: Animals; Disease Models, Animal; Epilepsy; Genetic Therapy; Hippocampus; Mice; Neurons; Pilocarpine; | 2023 |
Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Humans; Interleukin-6; Mice; Mi | 2023 |
Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Mefloquine; Neuropr | 2023 |
Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy.
Topics: Adenoviridae; Analysis of Variance; Animals; Apoptosis; Brain; Disease Models, Animal; Epilepsy; Hip | 2019 |
[Altered expressions of SphK1 and S1PR2 in hippocampus of epileptic rats].
Topics: Animals; Astrocytes; Epilepsy; Hippocampus; Male; Phosphotransferases (Alcohol Group Acceptor); Pilo | 2019 |
Neuroprotective effects and improvement of learning and memory elicited by erythravine and 11α-hydroxy-erythravine against the pilocarpine model of epilepsy.
Topics: Alkaloids; Animals; Convulsants; Epilepsy; Heterocyclic Compounds, 4 or More Rings; Hippocampus; Imm | 2020 |
Treatment with CCR2 antagonist is neuroprotective but does not alter epileptogenesis in the pilocarpine rat model of epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Chemokine CCL2; Disease Models, Animal; Epilepsy; Male; Microglia; | 2020 |
High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model.
Topics: Animals; Antibodies; Apoptosis; Autophagy; Disease Models, Animal; Epilepsy; Hippocampus; HMGB1 Prot | 2020 |
The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Epilepsy; Hippocampus; Lithium Chloride; Neur | 2020 |
Ictal onset sites and γ-aminobutyric acidergic neuron loss in epileptic pilocarpine-treated rats.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Female; GABAergic Neurons; Glutamate Decarboxylase | 2020 |
Chaihu-Longgu-Muli decoction relieves epileptic symptoms by improving autophagy in hippocampal neurons.
Topics: Animals; Anticonvulsants; Autophagosomes; Autophagy; Autophagy-Related Proteins; Behavior, Animal; D | 2020 |
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice.
Topics: Animals; Disease Models, Animal; Epilepsy; Male; Memory; Mice; Muscarinic Agonists; Pilocarpine | 2020 |
Transient receptor potential melastatin 2 contributes to neuroinflammation and negatively regulates cognitive outcomes in a pilocarpine-induced mouse model of epilepsy.
Topics: Animals; Behavior, Animal; Cognition; Cytokines; Disease Models, Animal; Epilepsy; Hippocampus; Infl | 2020 |
Time-variant Epileptic Brain Functional Connectivity of Focal and Generalized Seizure in Chronic Temporal Lobe Epilepsy Rat
Topics: Animals; Brain; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pilocarpine; Rats; Seizures | 2020 |
Baicalein Ameliorates Epilepsy Symptoms in a Pilocarpine-Induced Rat Model by Regulation of IGF1R.
Topics: Animals; Cell Proliferation; Epilepsy; Flavanones; Hippocampus; Inflammation; Male; Microglia; Piloc | 2020 |
Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; Equilibrative Nucleoside Transporter 1; Glutamic Acid; Hi | 2020 |
Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104.
Topics: Animals; Calcium-Binding Proteins; Cells, Cultured; Epilepsy; Excitatory Amino Acid Antagonists; Kyn | 2020 |
The Role of Hippocampal Neurogenesis in ANT-DBS for LiCl-Pilocarpine-Induced Epileptic Rats.
Topics: Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Doublecortin Protein; Epilepsy; Hippocamp | 2021 |
Deciphering key regulators involved in epilepsy-induced cardiac damage through whole transcriptome and proteome analysis in a rat model.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Epilepsy; Gene Expression Profiling; Gene R | 2021 |
Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice.
Topics: Animals; Anticonvulsants; Bumetanide; Drug Therapy, Combination; Epilepsy; Female; Mice; Phenobarbit | 2021 |
Complex effects of eslicarbazepine on inhibitory micro networks in chronic experimental epilepsy.
Topics: Adamantane; Animals; Anticonvulsants; CA1 Region, Hippocampal; Calcium; Dibenzazepines; Disease Mode | 2021 |
Maternal crack cocaine use in rats leads to depressive- and anxiety-like behavior, memory impairment, and increased seizure susceptibility in the offspring.
Topics: Animals; Anxiety; Cocaine-Related Disorders; Crack Cocaine; Epilepsy; Female; Male; Memory Disorders | 2021 |
MiR-101a-3p Attenuated Pilocarpine-Induced Epilepsy by Downregulating c-FOS.
Topics: Animals; Apoptosis; Autophagy; Cell Survival; Down-Regulation; Epilepsy; Hippocampus; MicroRNAs; Neu | 2021 |
The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Epilepsy; Genetic Predisposition | 2021 |
In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Pentylenetetrazole; Pilocarp | 2020 |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy.
Topics: Animals; Calcium; Clozapine; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Tem | 2021 |
Gastrodin attenuates lithium-pilocarpine-induced epilepsy by activating AMPK-mediated PPARα in a juvenile rat model.
Topics: Adenylate Kinase; Animals; Behavior, Animal; Benzyl Alcohols; Brain-Derived Neurotrophic Factor; Dis | 2021 |
Excitatory synaptic transmission in hippocampal area CA1 is enhanced then reduced as chronic epilepsy progresses.
Topics: Animals; CA1 Region, Hippocampal; Chronic Disease; Disease Progression; Epilepsy; Excitatory Postsyn | 2021 |
Short-Term Amygdala Low-Frequency Stimulation Does not Influence Hippocampal Interneuron Changes Observed in the Pilocarpine Model of Epilepsy.
Topics: Amygdala; Animals; Epilepsy; Hippocampus; Interneurons; Male; Pilocarpine; Rats; Rats, Wistar | 2021 |
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
Topics: Animals; Astrocytes; Calcium Signaling; Disease Models, Animal; Disease Progression; Disease Suscept | 2021 |
Decreased excitatory drive onto hilar neuronal nitric oxide synthase expressing interneurons in chronic models of epilepsy.
Topics: Animals; Chronic Disease; Convulsants; Epilepsy; Excitatory Postsynaptic Potentials; Gene Expression | 2021 |
Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network.
Topics: ADP-ribosyl Cyclase; Animals; Calcium; Cyclic ADP-Ribose; Disease Models, Animal; Electrophoresis; E | 2021 |
Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test.
Topics: Animals; Dietary Supplements; Epilepsy; Epilepsy, Temporal Lobe; Fish Oils; Morris Water Maze Test; | 2021 |
Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Lutein; Neuroprotective Agents; | 2021 |
Limbic progesterone receptor activity enhances neuronal excitability and seizures.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Neurons; Pilocarpine; Progesterone; | 2021 |
Fructose 1,6-bisphosphate is anticonvulsant and improves oxidative glucose metabolism within the hippocampus and liver in the chronic pilocarpine mouse epilepsy model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Fructose; Fructosediphosphates; Glucose; | 2021 |
Mice with conditional NeuroD1 knockout display reduced aberrant hippocampal neurogenesis but no change in epileptic seizures.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Doublecortin Domain P | 2017 |
Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy; GABA Plasma Membrane Transport P | 2017 |
A novel device for continuous long-term electroencephalogram recording and drug administration in mice with a nice, powerful and sophisticated wired system.
Topics: Animals; Anticonvulsants; Brain; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Dr | 2017 |
A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Astrocytes; Disease Models, Animal; Drug Therapy, Combi | 2017 |
Up-regulated BAFF and BAFF receptor expression in patients with intractable temporal lobe epilepsy and a pilocarpine-induced epilepsy rat model.
Topics: Adolescent; Adult; Animals; B-Cell Activating Factor; B-Cell Activation Factor Receptor; Blotting, W | 2017 |
Altered MT1 and MT2 melatonin receptors expression in the hippocampus of pilocarpine-induced epileptic rats.
Topics: Animals; Epilepsy; Gene Expression; Hippocampus; Male; Pilocarpine; Rats; Rats, Wistar; Receptor, Me | 2017 |
DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.
Topics: Action Potentials; Animals; Anthracenes; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; D | 2017 |
Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cells, Cultured; Epilepsy; Flavones; Male; Matrix | 2017 |
MicroRNA-129-5p inhibits the development of autoimmune encephalomyelitis-related epilepsy by targeting HMGB1 through the TLR4/NF-kB signaling pathway.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Epilepsy; Escherichia coli; Genetic Vectors; H | 2017 |
Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Convulsants; Electroencephalography; Epilepsy; Epilepsy | 2017 |
The Role of 5-HTR6 in Mossy Fiber Sprouting: Activating Fyn and p-ERK1/2 in Pilocarpine-Induced Chronic Epileptic Rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Flavonoids; GAP-43 Protein; Male; Mitogen-Activated Prote | 2017 |
Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain; Cholinergic Agents; Epilepsy; Humans; Mice; Mic | 2017 |
Inherent vulnerabilities in monoaminergic pathways predict the emergence of depressive impairments in an animal model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Convulsants; Depression; Disease Models, Animal; Epil | 2017 |
Silencing of P2X7R by RNA interference in the hippocampus can attenuate morphological and behavioral impact of pilocarpine-induced epilepsy.
Topics: Animals; Convulsants; Epilepsy; Gene Knockdown Techniques; Hippocampus; Male; Pilocarpine; Rats; Rat | 2017 |
SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model.
Topics: Animals; Disease Models, Animal; Dual-Specificity Phosphatases; Epilepsy; Gene Expression Regulation | 2017 |
Dynamic regulation effect of long non-coding RNA-UCA1 on NF-kB in hippocampus of epilepsy rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Disease Progression; Epilepsy; Gene Expression Re | 2017 |
Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors.
Topics: Animals; Cell Differentiation; Convulsants; Disease Models, Animal; Embryo, Mammalian; Epilepsy; Exp | 2017 |
Novel insights into the effect of paroxetine administration in pilocarpine‑induced chronic epileptic rats.
Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epileps | 2017 |
[Expression and spatial distribution of P2X7 receptor in pilocarpine-induced epileptic rat hippocampus].
Topics: Animals; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Hippocampus; Pilocarpine; Rat | 2017 |
Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy.
Topics: Animals; Complement C1q; Complement C3; Epilepsy; Hippocampus; Male; Pilocarpine; Rats, Sprague-Dawl | 2018 |
Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy.
Topics: Action Potentials; Animals; Autonomic Nervous System; Biperiden; Chronic Disease; Cytokines; Disease | 2017 |
In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET.
Topics: Animals; Benzamides; Brain; Carbon Radioisotopes; Epilepsy; Ligands; Male; Pilocarpine; Positron-Emi | 2017 |
Functional Metaplasticity of Hippocampal Schaffer Collateral-CA1 Synapses Is Reversed in Chronically Epileptic Rats.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Epilepsy; Hippocampus; Long-Term Potentiation; N | 2017 |
LC-MS/MS imaging with thermal film-based laser microdissection.
Topics: Acetylcholine; Animals; Choline; Chromatography, Liquid; Epilepsy; Female; gamma-Aminobutyric Acid; | 2018 |
Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Cerebral Cortex; Cognition Disorders; Convulsants; | 2018 |
Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cyclooxygenase Inh | 2018 |
Loss of constitutive functional γ-aminobutyric acid type A-B receptor crosstalk in layer 5 pyramidal neurons of human epileptic temporal cortex.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adolescent; Adult; Animals; Baclofen; Carbazoles; Cyclic AMP | 2018 |
Protective Effects of Protocatechuic Acid on Seizure-Induced Neuronal Death.
Topics: Animals; Antioxidants; Cell Death; Epilepsy; Glutathione; Hippocampus; Hydroxybenzoates; Male; Micro | 2018 |
Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy.
Topics: Animals; Apoptosis; Disease Models, Animal; Ectopic Gene Expression; Epilepsy; Hippocampus; Male; Mi | 2018 |
Alterations of L-type voltage dependent calcium channel alpha 1 subunit in the hippocampal CA3 region during and after pilocarpine-induced epilepsy.
Topics: Animals; CA3 Region, Hippocampal; Calcium Channels, L-Type; Epilepsy; Female; Mice; Mice, Inbred C57 | 2018 |
Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis.
Topics: Animals; Atorvastatin; Convulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy; Female; Male; M | 2018 |
Disruption of the GluA2/GAPDH complex using TAT-GluA2NT1-3-2 peptide protects against AMPAR-mediated excitotoxicity after epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administrat | 2018 |
Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cytokines; Dexamethasone; Dinoprostone; Disease Mode | 2018 |
Ephrin‑b3 modulates hippocampal neurogenesis and the reelin signaling pathway in a pilocarpine‑induced model of epilepsy.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Doublecortin Protein; Ephrin-B3; Epilepsy; Extracellular | 2018 |
Na
Topics: Animals; Antibodies; Anticonvulsants; Caspase 3; Disease Models, Animal; Drug Evaluation, Preclinica | 2018 |
RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice, Inbred C57 | 2018 |
Antiepileptic effect of uridine may be caused by regulating dopamine release and receptor expression in corpus striatum.
Topics: Animals; Anticonvulsants; Brain; Corpus Striatum; Dopamine; Epilepsy; Male; Mice; Pilocarpine; Recep | 2018 |
Clustering of spontaneous recurrent seizures separated by long seizure-free periods: An extended video-EEG monitoring study of a pilocarpine mouse model.
Topics: Animals; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Male; Mi | 2018 |
Ketogenic Diet Based on Extra Virgin Coconut Oil Has No Effects in Young Wistar Rats With Pilocarpine-Induced Epilepsy.
Topics: Animals; Coconut Oil; Cocos; Diet, Ketogenic; Epilepsy; Male; Pilocarpine; Rats; Rats, Wistar | 2018 |
Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1.
Topics: 4-Aminopyridine; Adolescent; Adult; Animals; Brain; Carbazoles; Child; Cyclic GMP; Cyclic GMP-Depend | 2018 |
LncRNA UCA1 inhibits epilepsy and seizure-induced brain injury by regulating miR-495/Nrf2-ARE signal pathway.
Topics: Animals; Antioxidant Response Elements; Apoptosis; Brain Injuries; Cells, Cultured; Epilepsy; Gene E | 2018 |
Different behavioral and pathological changes between epilepsy-associated depression and primary depression models.
Topics: Animals; Depression; Disease Models, Animal; Epilepsy; Hippocampus; Lithium Chloride; Male; Pilocarp | 2018 |
Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy.
Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Biomarkers; Caspa | 2018 |
The effect of dichloroacetate in mouse models of epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Dichloroacetic Acid; Disease Models, An | 2018 |
Imaging correlates of behavioral impairments: An experimental PET study in the rat pilocarpine epilepsy model.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Interpersonal Relations; Mental Disorders; Piloca | 2018 |
Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells.
Topics: Adult; Analysis of Variance; Animals; Anticonvulsants; Biophysics; Cells, Cultured; Dentate Gyrus; D | 2018 |
Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy; Hepatocyte Growth Factor; Hippocampus; I | 2018 |
Lithium affects rat hippocampal electrophysiology and epileptic seizures in a dose dependent manner.
Topics: Animals; Anticonvulsants; Brain Waves; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; Lith | 2018 |
Ghrelin improves pilocarpine‑induced cerebral cortex inflammation in epileptic rats by inhibiting NF‑κB and TNF‑α.
Topics: Animals; Anti-Inflammatory Agents; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Epileps | 2018 |
Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A [
Topics: Acholeplasmataceae; Animals; Brain; Chronic Disease; Disease Models, Animal; Epilepsy; Fluorodeoxygl | 2018 |
Disruption of GluR2/GAPDH Complex Interaction by TAT-GluR2
Topics: Amino Acid Sequence; Animals; Cell Death; Cell Nucleus; Epilepsy; Glyceraldehyde-3-Phosphate Dehydro | 2018 |
Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms.
Topics: Anacardic Acids; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Electroshock; Epile | 2018 |
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.
Topics: Animals; Anticonvulsants; Computer Simulation; Disease Models, Animal; Drug Discovery; Epilepsy; Epi | 2018 |
Long-term monotherapy treatment with vitamin E reduces oxidative stress, but not seizure frequency in rats submitted to the pilocarpine model of epilepsy.
Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Epilepsy; Hippocamp | 2018 |
Static magnetic fields reduce epileptiform activity in anesthetized rat and monkey.
Topics: Animals; Behavior, Animal; Case-Control Studies; Cerebral Cortex; Electroencephalography; Epilepsy; | 2018 |
Coronary vasodilation impairment in pilocarpine model of epilepsy.
Topics: Animals; Coronary Artery Disease; Disease Models, Animal; Epilepsy; Male; Muscarinic Agonists; Piloc | 2019 |
Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cannabidiol; Disease Models, Animal; Epilepsy; Epilepsy, | 2019 |
Catalpol Exerts an Anti-Epilepticus Effect, Possibly by Regulating the Nrf2-Keap1-ARE Signaling Pathway.
Topics: Animals; China; Disease Models, Animal; Epilepsy; Iridoid Glucosides; Kelch-Like ECH-Associated Prot | 2018 |
Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy.
Topics: Animals; Cell Encapsulation; Cell Line; Drug Delivery Systems; Epilepsy; Glial Cell Line-Derived Neu | 2019 |
Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Hippocampus; Iridoid Glucosides; Lithium; Mal | 2019 |
[Efficacy of brain-targeted rapamycin for treatment of epilepsy in rats].
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; | 2018 |
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; | 2019 |
Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Comorbidity; Depressive Disorder; Disease | 2019 |
Chronic mild hypoxia promotes hippocampal neurogenesis involving Notch1 signaling in epileptic rats.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cognition; Epilepsy; Hippocampus; Hypoxia; Male; | 2019 |
(-)-Epigallocatechin-3-Gallate Protects Against Lithium-Pilocarpine-Induced Epilepsy by Inhibiting the Toll-Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Signaling Pathway.
Topics: Animals; Catechin; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Lithium; | 2019 |
Proliferation of NG2 cells in the epileptic hippocampus.
Topics: Animals; Antigens; Calbindin 2; Calbindins; CD11b Antigen; Cell Proliferation; Epilepsy; Glial Fibri | 2019 |
Dexamethasone ameliorates the damage of hippocampal filamentous actin cytoskeleton but is not sufficient to cease epileptogenesis in pilocarpine induced epileptic mice.
Topics: Actin Cytoskeleton; Animals; Anti-Inflammatory Agents; Dexamethasone; Epilepsy; Hippocampus; Male; M | 2019 |
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutamic | 2019 |
Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy.
Topics: Animals; Epilepsy; Excitatory Postsynaptic Potentials; Lipid A; Lipopolysaccharides; Male; Neurons; | 2019 |
ADENOSINE A1 RECEPTOR AGONIST PROTECTS AGAINST HIPPOCAMPAL NEURONAL INJURY AFTER LITHIUM CHLORIDE-PILOCARPINE-INDUCED EPILEPSY.
Topics: Adenosine A1 Receptor Agonists; Animals; Apoptosis; Disease Models, Animal; Epilepsy; Hippocampus; L | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, | 2019 |
The novel GLP-1/GIP dual receptor agonist DA3-CH is neuroprotective in the pilocarpine-induced epileptogenesis rat model.
Topics: Animals; Disease Models, Animal; Epilepsy; Glucagon-Like Peptide-1 Receptor; Male; Neuroprotective A | 2019 |
Impairments in cognitive functions and emotional and social behaviors in a rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anxiety; Behavior, Animal; Cognition; Emotions; Epilepsy; Epilepsy, Temporal Lobe; Explorat | 2019 |
Transient receptor potential vanilloid 4 is involved in the upregulation of connexin expression following pilocarpine-induced status epilepticus in mice.
Topics: Animals; Connexin 43; Connexins; Epilepsy; Gap Junction beta-1 Protein; Hippocampus; Leucine; Male; | 2019 |
Anti-epileptic effect of 16-O-acetyldigitoxigenin via suppressing mTOR signaling pathway.
Topics: Animals; Anticonvulsants; Apocynaceae; Caspase 3; Digitoxigenin; Drugs, Chinese Herbal; Epilepsy; Hi | 2019 |
Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model.
Topics: Animals; Astrocytes; Brain; Depression; Depressive Disorder; Disease Models, Animal; Epilepsy; Epoxi | 2019 |
Hippocampal CA1 and cortical interictal oscillations in the pilocarpine model of epilepsy.
Topics: Animals; Brain Waves; CA1 Region, Hippocampal; Cerebral Cortex; Cortical Synchronization; Epilepsy; | 2019 |
Changes in excitatory and inhibitory receptor expression and network activity during induction and establishment of epilepsy in the rat Reduced Intensity Status Epilepticus (RISE) model.
Topics: Animals; Disease Models, Animal; Epilepsy; GluK2 Kainate Receptor; Hippocampus; Muscarinic Agonists; | 2019 |
Spontaneous Recurrent Seizures Mediated Cardiac Dysfunction via mTOR Pathway Upregulation: A Putative Target for SUDEP Management.
Topics: Animals; Disease Models, Animal; Epilepsy; Fibrosis; Heart Diseases; Lithium Compounds; Male; Myocar | 2019 |
Enhanced synaptic connectivity in the dentate gyrus during epileptiform activity: network simulation.
Topics: Algorithms; Computer Simulation; Dentate Gyrus; Electrophysiological Phenomena; Epilepsy; Humans; In | 2013 |
The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease.
Topics: Animals; Behavioral Symptoms; Biomarkers; Bipolar Disorder; Calbindin 2; Dentate Gyrus; Disease Mode | 2013 |
Omega-3 fatty acid supplementation reduces resting heart rate of rats with epilepsy.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Epilepsy; Fatty Acids, Omega-3; Heart Rate; Mu | 2013 |
Role of mitochondrial fission in neuronal injury in pilocarpine-induced epileptic rats.
Topics: Animals; Epilepsy; Male; Mitochondrial Dynamics; Neurons; Pilocarpine; Rats; Rats, Wistar | 2013 |
GABAergic transmission facilitates ictogenesis and synchrony between CA3, hilus, and dentate gyrus in slices from epileptic rats.
Topics: Animals; CA3 Region, Hippocampal; Cerebral Cortex; Dentate Gyrus; Epilepsy; Hippocampus; Male; Neura | 2013 |
Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy.
Topics: Animals; Dependovirus; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glutathione Tra | 2013 |
[Survival of calbindin, calretinin and parvalbumin positive neurons in mouse hippocampal CA area at chronic stage of pilocarpine-induced epilepsy].
Topics: Animals; Calbindin 2; Calbindins; Cell Survival; Chronic Disease; Epilepsy; gamma-Aminobutyric Acid; | 2013 |
Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity.
Topics: Animals; Depression; Disease Models, Animal; Disease Susceptibility; Epilepsy; Galanin; Gene Express | 2013 |
STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy.
Topics: Animals; Behavior, Animal; Cells, Cultured; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Aci | 2013 |
Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy.
Topics: Animals; Cerebral Cortex; Citric Acid Cycle; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mi | 2014 |
Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavioral Symptoms; Brain; Chronic Disease; | 2014 |
Decreased expression of proteins involved in energy metabolism in the hippocampal granular layer of rats submitted to the pilocarpine epilepsy model.
Topics: Animals; Energy Metabolism; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Male; Pilocarpine; Prote | 2014 |
[Rapamycin improves learning and memory ability in ICR mice with pilocarpine-induced temporal lobe epilepsy].
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy; Learning; Memory; Mice; Mice, Inbred ICR; Neu | 2013 |
[Comparison of seizure induced by different drugs in ICR Mice].
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetra | 2013 |
Unique behavioral characteristics and microRNA signatures in a drug resistant epilepsy model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Drug Resistance; Electroencephal | 2014 |
Pilocarpine-induced epilepsy is associated with actin cytoskeleton reorganization in the mossy fiber-CA3 synapses.
Topics: Actins; Animals; Cytoskeleton; Disease Models, Animal; Disks Large Homolog 4 Protein; Epilepsy; Gene | 2014 |
In vivo imaging of mGluR5 changes during epileptogenesis using [11C]ABP688 PET in pilocarpine-induced epilepsy rat model.
Topics: Amygdala; Animals; Epilepsy; Hippocampus; Male; Muscarinic Agonists; Oximes; Pilocarpine; Positron-E | 2014 |
Involvement of thalamus in initiation of epileptic seizures induced by pilocarpine in mice.
Topics: Algorithms; Animals; Atropine; CA1 Region, Hippocampal; Data Interpretation, Statistical; Electrodes | 2014 |
Lovastatin decreases the synthesis of inflammatory mediators during epileptogenesis in the hippocampus of rats submitted to pilocarpine-induced epilepsy.
Topics: Animals; Anticholesteremic Agents; Cytokines; Disease Models, Animal; Epilepsy; Gene Expression Regu | 2014 |
Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration.
Topics: Analysis of Variance; Animals; Calcium-Binding Proteins; CD11b Antigen; Cell Count; Chronic Disease; | 2015 |
Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chronic Diseas | 2014 |
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Dis | 2014 |
Transient muscarinic and glutamatergic stimulation of neural stem cells triggers acute and persistent changes in differentiation.
Topics: Animals; Chronic Disease; Disease Models, Animal; Epilepsy; GABAergic Neurons; Gap Junctions; Glutam | 2014 |
Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Biophysics; Carbamazepine; Convulsants; Disease Models, Animal; Electric S | 2014 |
5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Male; Pilocarpine; Rats, | 2015 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
Hypoxia inducible factor-1α expression is associated with hippocampal apoptosis during epileptogenesis.
Topics: Animals; Apoptosis; Convulsants; Dizocilpine Maleate; Electroencephalography; Epilepsy; Excitatory A | 2014 |
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green | 2015 |
Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; CHO Cells; Convulsants; Cricet | 2015 |
Alteration in 5-HT₂C, NMDA receptor and IP3 in cerebral cortex of epileptic rats: restorative role of Bacopa monnieri.
Topics: Animals; Anxiety; Bacopa; Behavior, Animal; Cerebral Cortex; Convulsants; Epilepsy; Excitatory Amino | 2015 |
The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Epilepsy; Male; Piloc | 2014 |
Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats.
Topics: Animals; Apoptosis; Astrocytes; Brain; Caspase 3; Disease Models, Animal; Epilepsy; Fluoxetine; Gluc | 2015 |
Epilepsy-induced electrocardiographic alterations following cardiac ischemia and reperfusion in rats.
Topics: Animals; Disease Models, Animal; Electric Conductivity; Electrocardiography; Epilepsy; Heart; Heart | 2015 |
Inhibition of the small GTPase Cdc42 in regulation of epileptic-seizure in rats.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; cdc42 GTP-Binding Protein; Disease Models, Anim | 2015 |
Transplantation of bone marrow mononuclear cells modulates hippocampal expression of growth factors in chronically epileptic animals.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chronic Disease; Disease Models, Animal; Ep | 2015 |
A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocamp | 2015 |
Altered Expression of Intersectin1-L in Patients with Refractory Epilepsy and in Experimental Epileptic Rats.
Topics: Adaptor Proteins, Vesicular Transport; Adolescent; Adult; Animals; Brain; Disease Models, Animal; Dr | 2015 |
Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cognition Disorders; Disease Models, Animal; | 2015 |
Neurosteroidal modulation of in vitro epileptiform activity is enhanced in pilocarpine-treated epileptic rats.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Desoxycorticosterone; Entorhinal Cortex; Epilepsy; In Vit | 2015 |
The loss of Ivy cells and the hippocampal input modulatory O-LM cells contribute to the emergence of hyperexcitability in the hippocampus.
Topics: Animals; Axons; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Male; Neurons; Neurope | 2015 |
Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models.
Topics: Analysis of Variance; Animals; Arginase; beta-N-Acetylhexosaminidases; Convulsants; Cytokines; Disea | 2015 |
[Dynamic expressions of Nav1.2 and Nav1.6 in hippocampal CA3 region of epileptic rats].
Topics: Animals; CA3 Region, Hippocampal; Epilepsy; Immunohistochemistry; Male; NAV1.2 Voltage-Gated Sodium | 2015 |
Fish oil provides protection against the oxidative stress in pilocarpine model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Fish Oils; Male; Neuroprotective Agents; Oxidative Stress | 2015 |
[Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models].
Topics: Animals; Calpain; Disease Models, Animal; Epilepsy; Hippocampus; Levetiracetam; Pilocarpine; Piracet | 2015 |
Effects of TRPV1 on the hippocampal synaptic plasticity in the epileptic rat brain.
Topics: Animals; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy; Gene Expression Regulat | 2015 |
Dysregulation of long non-coding RNAs in mouse models of localization-related epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Mice; Pilocarpine; RNA, Long Noncoding | 2015 |
Region-specific alterations of AMPA receptor phosphorylation and signaling pathways in the pilocarpine model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Male; Phosphorylation; Pilocarpine; Rats; Ra | 2015 |
Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Electroencep | 2015 |
Association of Alpha-Soluble NSF Attachment Protein with Epileptic Seizure.
Topics: Adolescent; Adult; Animals; Cerebral Cortex; Child; Down-Regulation; Epilepsy; Epilepsy, Temporal Lo | 2015 |
[Changes in CD40 expression in the pallium and hippocampus in epileptic rats].
Topics: Animals; CD40 Antigens; Epilepsy; Hippocampus; Immunohistochemistry; Lithium; Microglia; Pilocarpine | 2015 |
High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process?
Topics: Animals; Behavior, Animal; Biomarkers; C-Reactive Protein; Convulsants; Cytokines; Epilepsy; Fatty A | 2015 |
Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models.
Topics: Action Potentials; Adolescent; Adult; Animals; Blotting, Western; Disease Models, Animal; Down-Regul | 2016 |
Sulforaphane is anticonvulsant and improves mitochondrial function.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electron Transport Complex I; Electro | 2015 |
MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy--comparison with human epileptic samples.
Topics: Adult; Animals; Biomarkers; Case-Control Studies; Cluster Analysis; Epilepsy; Female; Gene Expressio | 2015 |
Myeloperoxidase Nuclear Imaging for Epileptogenesis.
Topics: 4-Aminobenzoic Acid; Animals; Blotting, Western; Disease Models, Animal; Epilepsy; Flow Cytometry; M | 2016 |
Alterations in hippocampal myelin and oligodendrocyte precursor cells during epileptogenesis.
Topics: Animals; Cell Differentiation; Diazepam; Disease Models, Animal; Epilepsy; Hippocampus; Muscarinic A | 2015 |
Neurofibromin Regulates Seizure Attacks in the Rat Pilocarpine-Induced Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy; Hippocampus; Lentivirus; Male; Neurofibr | 2016 |
Increased Expression of Rac1 in Epilepsy Patients and Animal Models.
Topics: Adult; Aminoquinolines; Animals; Behavior, Animal; Brain; Case-Control Studies; Disease Models, Anim | 2016 |
N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model.
Topics: Animals; Antigens, Nuclear; Chronic Disease; Depressive Disorder; Disease Models, Animal; Epilepsy; | 2016 |
[Protective effects of Purα on rat hippocampus DNA damage induced by epilepsy].
Topics: Animals; DNA Damage; DNA Repair; DNA-Binding Proteins; Epilepsy; Hippocampus; Pilocarpine; Rats; Tra | 2015 |
Pilocarpine-induced epilepsy alters the expression and daily variation of the nuclear receptor RORα in the hippocampus of rats.
Topics: Animals; Chronic Disease; Circadian Rhythm; Epilepsy; Gene Expression Regulation; Hippocampus; Male; | 2016 |
Xenograft of human umbilical mesenchymal stem cells from Wharton's jelly as a potential therapy for rat pilocarpine-induced epilepsy.
Topics: Animals; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Epilepsy; Hippocampus; Human | 2016 |
Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure.
Topics: Animals; Anticonvulsants; Antioxidants; Autophagy; Autophagy-Related Proteins; Cannabidiol; Epilepsy | 2016 |
Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats.
Topics: Age Factors; Animals; Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Male; Perio | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Characterization of Intracranial Pressure Behavior in Chronic Epileptic Animals: A Preliminary Study.
Topics: Animals; Anticonvulsants; Brain; Chronic Disease; Disease Models, Animal; Epilepsy; Epilepsy, Tempor | 2016 |
Role of CA3 theta-modulated interneurons during the transition to spontaneous seizures.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Disease Models, Animal; Epilepsy; Interneurons; | 2016 |
Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Brain; Convulsants; Elec | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice.
Topics: Animals; Anticonvulsants; Antioxidants; Apigenin; Behavior, Animal; Chlorogenic Acid; Epilepsy; gamm | 2016 |
Abnormal Expression of FBXL20 in Refractory Epilepsy Patients and a Pilocarpine-Induced Rat Model.
Topics: Adolescent; Adult; Animals; Disease Models, Animal; Epilepsy; F-Box Proteins; Female; Hippocampus; H | 2016 |
Administration of copper reduced the hyper-excitability of neurons in CA1 hippocampal slices from epileptic rats.
Topics: Animals; Copper; Epilepsy; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Neurons; Piloca | 2016 |
Residual neurogenesis in chronically epileptic hippocampus of mice.
Topics: Animals; Bromodeoxyuridine; Cell Movement; Chronic Disease; Disease Models, Animal; Epilepsy; Female | 2016 |
Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition.
Topics: Animals; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Glutamate-Ammo | 2017 |
Medial Ganglionic Eminence Cells Freshly Obtained or Expanded as Neurospheres Show Distinct Cellular and Molecular Properties in Reducing Epileptic Seizures.
Topics: Animals; Cell Differentiation; Cells, Cultured; Creatine; Disease Models, Animal; Embryo, Mammalian; | 2017 |
Activity of the anticonvulsant lacosamide in experimental and human epilepsy via selective effects on slow Na
Topics: Acetamides; Adult; Analysis of Variance; Animals; Anticonvulsants; Biophysics; Cells, Cultured; Dise | 2017 |
Altered Expression of CXCL13 and CXCR5 in Intractable Temporal Lobe Epilepsy Patients and Pilocarpine-Induced Epileptic Rats.
Topics: Adolescent; Adult; Animals; Biomarkers; Chemokine CXCL13; Child; Epilepsy; Epilepsy, Temporal Lobe; | 2017 |
Intraperitoneal injection of IL-4/IFN-γ modulates the proportions of microglial phenotypes and improves epilepsy outcomes in a pilocarpine model of acquired epilepsy.
Topics: Animals; Anticonvulsants; Brain; Cognition Disorders; Disease Models, Animal; Epilepsy; Immunologic | 2017 |
Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Ischemia; Disease Models, Animal; Epilepsy; | 2017 |
Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy.
Topics: Animals; Connexin 43; Connexins; Disease Models, Animal; Epilepsy; Gap Junction delta-2 Protein; Hip | 2017 |
Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice.
Topics: Animals; Convulsants; Cytokines; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocamp | 2017 |
PDI regulates seizure activity via NMDA receptor redox in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Ep | 2017 |
Effect of synaptic adhesion-like molecule 3 on epileptic seizures: Evidence from animal models.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Membrane Glycoproteins | 2017 |
Retrosplenial granular b cortex in normal and epileptic rats: a stereological study.
Topics: Analysis of Variance; Animals; Cell Count; Cerebral Cortex; Disease Models, Animal; Electroshock; Ep | 2008 |
Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE).
Topics: Animals; Chloride Channels; Chlorides; Disease Models, Animal; Epilepsy; Gene Expression Regulation; | 2008 |
Deducing the bioactive face of hydantoin anticonvulsant drugs using NMR spectroscopy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Hydantoins; Magnetic Resonance Spectrosc | 2008 |
[Detrended fluctuation analysis of epileptic rat EEG].
Topics: Animals; Brain; Electroencephalography; Epilepsy; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Sig | 2008 |
The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats.
Topics: Animals; Antimanic Agents; Cell Death; Convulsants; Disease Models, Animal; Electroencephalography; | 2008 |
Dynamic seizure-related changes in extracellular signal-regulated kinase activation in a mouse model of temporal lobe epilepsy.
Topics: Animals; Biomarkers; Cell Count; Convulsants; Disease Models, Animal; Enzyme Activation; Epilepsy; E | 2008 |
The role of trace elements in the pathogenesis and progress of pilocarpine-induced epileptic seizures.
Topics: Animals; Calcium; Cerebral Cortex; Copper; Dentate Gyrus; Epilepsy; Hippocampus; Metals; Microscopy, | 2008 |
Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Cerebral Cortex; Chronic Disease; Convulsa | 2008 |
Impaired expression and function of group II metabotropic glutamate receptors in pilocarpine-treated chronically epileptic rats.
Topics: Animals; Anticonvulsants; Blotting, Western; Brain; Chronic Disease; Convulsants; Cyclopropanes; Epi | 2008 |
Oral administration of fructose-1,6-diphosphate has anticonvulsant activity.
Topics: 4-Butyrolactone; Action Potentials; Administration, Oral; Animals; Anticonvulsants; Brain; Cerebral | 2008 |
Effect of electroacupuncture stimulation of hindlimb on seizure incidence and supragranular mossy fiber sprouting in a rat model of epilepsy.
Topics: Animals; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Electroacupuncture; Electrodes, Im | 2008 |
Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Cell Death; Cell Proliferation; Convulsants; Disease Models | 2008 |
Attenuation of epilepsy-induced brain damage in the temporal cortices of rats by exposure to LTP-patterned magnetic fields.
Topics: Animals; Brain Injuries; Dose-Response Relationship, Radiation; Epilepsy; Lithium Chloride; Long-Ter | 2009 |
Effect of infrared laser irradiation on amino acid neurotransmitters in an epileptic animal model induced by pilocarpine.
Topics: Alanine Transaminase; Amino Acids; Analysis of Variance; Animals; Aspartate Aminotransferases; Aspar | 2009 |
Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Body Weight; Diet, Ketogenic; Disease Models, | 2009 |
Insidious weight gain in prepubertal seized rats treated with an atypical neuroleptic: the role of food consumption, fluid consumption, and spontaneous ambulatory activity.
Topics: Acepromazine; Analysis of Variance; Animals; Antipsychotic Agents; Body Weight; Disease Models, Anim | 2009 |
Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy.
Topics: Animals; Cell Death; Cerebral Cortex; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mice; Ner | 2009 |
Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures.
Topics: Analysis of Variance; Animals; Cell Count; Cerebral Cortex; Disease Models, Animal; Electroencephalo | 2009 |
Longitudinal microPET imaging of brain glucose metabolism in rat lithium-pilocarpine model of epilepsy.
Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Electroencephalography; Epilepsy; Fluorodeoxy | 2009 |
Bilateral anterior thalamic nucleus lesions are not protective against seizures in chronic pilocarpine epileptic rats.
Topics: Animals; Anterior Thalamic Nuclei; Epilepsy; Male; Pilocarpine; Rats; Rats, Wistar; Seizures | 2009 |
Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Progression; Dose-Response Re | 2009 |
The changed immunoreactivity of StarD6 after pilocarpine-induced epilepsy.
Topics: Active Transport, Cell Nucleus; Animals; Carrier Proteins; Cell Nucleus; Cholesterol; Convulsants; C | 2009 |
Down-regulation of cerebellar 5-HT(2C) receptors in pilocarpine-induced epilepsy in rats: therapeutic role of Bacopa monnieri extract.
Topics: Animals; Anticonvulsants; Ataxia; Bacopa; Carbamazepine; Cerebellum; Down-Regulation; Drug Evaluatio | 2009 |
A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Estrous Cycle; Female; Pentobarbital; Pi | 2009 |
Down-regulation of APLP1 mRNA expression in hippocampus of pilocarpine-induced epileptic rats.
Topics: Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Base Sequence; Disease Models, Animal; | 2009 |
Adenosine A2A receptor deficient mice are partially resistant to limbic seizures.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Mic | 2009 |
Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration | 2009 |
Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Animals; Anxiety Disorders; Brain; Cognition Disorders; Convulsants; Disease Models, Animal; Epileps | 2009 |
Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus.
Topics: Animals; Cerebral Cortex; Chronic Disease; Convulsants; Cyclic AMP-Dependent Protein Kinases; Diseas | 2009 |
Neurobehavioral maturation of offspring from epileptic dams: study in the rat lithium-pilocarpine model.
Topics: Age Factors; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Body Weight; Chi-Squ | 2009 |
Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Choroid Plexus; Chronic Dis | 2010 |
Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine.
Topics: Animals; Catalase; Chronic Disease; Epilepsy; Hippocampus; Lipid Peroxidation; Male; Nitrites; Oxida | 2009 |
Lipoic Acid increases hippocampal choline acetyltransferase and acetylcholinesterase activities and improvement memory in epileptic rats.
Topics: Acetylcholinesterase; Animals; Choline O-Acetyltransferase; Epilepsy; Hippocampus; Male; Memory; Pil | 2010 |
A selective interplay between aberrant EPSPKA and INaP reduces spike timing precision in dentate granule cells of epileptic rats.
Topics: Action Potentials; Animals; Biophysics; Computer Simulation; Dentate Gyrus; Disease Models, Animal; | 2010 |
Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: antagonism by Bacopa monnieri.
Topics: Animals; Anticonvulsants; Bacopa; Carbamazepine; Disease Models, Animal; Epilepsy; Ergolines; Hippoc | 2009 |
Effects of lipoic acid on oxidative stress in rat striatum after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Catalase; Convulsants; Corpus Striatum; Disease Models, Animal; Drug Interact | 2010 |
Glucose utilization in the brain during acute seizure is a useful biomarker for the evaluation of anticonvulsants: effect of methyl ethyl ketone in lithium-pilocarpine status epilepticus rats.
Topics: Animals; Anticonvulsants; Biomarkers; Brain; Butanones; Drug Evaluation, Preclinical; Epilepsy; Gluc | 2009 |
Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Apoptosis; Apoptosis Regulatory Proteins; Calbin | 2010 |
Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Comorbidity; Convulsants; Depressive Disorder; Dis | 2010 |
Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpine.
Topics: Acetates; Acute Disease; Animals; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; | 2010 |
Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Hippocampus; Humans; Im | 2009 |
Qualitative analysis of hippocampal plastic changes in rats with epilepsy supplemented with oral omega-3 fatty acids.
Topics: Administration, Oral; Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine | 2010 |
Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy.
Topics: Animals; Antigens; Blood-Brain Barrier; Capillaries; Cell Proliferation; Convulsants; Disease Models | 2010 |
Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy.
Topics: Animals; Epilepsy; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscop | 2011 |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach.
Topics: Alcohol Drinking; Animals; Death, Sudden; Disease Models, Animal; Epilepsy; Male; Muscarinic Agonist | 2009 |
Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats.
Topics: Animals; Anticonvulsants; Astrocytes; Chronic Disease; Epilepsy; Gliosis; Hippocampus; Interleukin-1 | 2010 |
Increased excitability and metabolism in pilocarpine induced epileptic rats: effect of Bacopa monnieri.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Bacopa; Carbamazepine; Epilepsy; Epinephrine; Insuli | 2010 |
Network dynamics during development of pharmacologically induced epileptic seizures in rats in vivo.
Topics: Animals; Cortical Synchronization; Electroencephalography; Electrooculography; Epilepsy; Interneuron | 2010 |
Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: effect of Bacopa monnieri and bacoside A.
Topics: Animals; Anticonvulsants; Behavioral Symptoms; Bicuculline; Carbamazepine; Cerebellum; Disease Model | 2010 |
Hippocampal interictal spikes disrupt cognition in rats.
Topics: Animals; Cognition Disorders; Conditioning, Operant; Confidence Intervals; Electroencephalography; E | 2010 |
Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis.
Topics: Animals; Epilepsy; Gene Expression; Gene Expression Profiling; Genomics; Hippocampus; Male; Pilocarp | 2010 |
Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice.
Topics: Acute Disease; Animals; Behavior, Animal; Cell Death; Disease Models, Animal; Epilepsy; Female; Hipp | 2010 |
Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Long-Term Potentiation | 2010 |
Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Epilepsy; Female; Male; Motor Activity; Pilocarpine; | 2010 |
Prenatal stress potentiates pilocarpine-induced epileptic behaviors in infant rats both time and sex dependently.
Topics: Analysis of Variance; Animals; Animals, Newborn; Corticosterone; Disease Models, Animal; Epilepsy; F | 2010 |
Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mossy Fibers, Hippocampal | 2010 |
Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Dantrolene; Dizocilpine Maleate; Epilepsy; Excitatory | 2010 |
Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus.
Topics: Animals; Cerebrovascular Circulation; Convulsants; Disease Models, Animal; Epilepsy; Hippocampus; Ma | 2010 |
Inflammation enhances epileptogenesis in the developing rat brain.
Topics: Age Factors; Aging; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy; Gliosis; Inflamma | 2010 |
Proteomic profiling of the epileptic dentate gyrus.
Topics: Actins; Animals; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Electrophoresis, Gel | 2010 |
Effects of selective serotonin reuptake inhibitors on GABAergic inhibition in the hippocampus of normal and pilocarpine induced epileptic rats.
Topics: Analysis of Variance; Animals; Citalopram; Electroencephalography; Epilepsy; Fluoxetine; gamma-Amino | 2010 |
Neuronal damage and memory deficits after seizures are reversed by ascorbic acid?
Topics: Animals; Antioxidants; Ascorbic Acid; Epilepsy; Hippocampus; Male; Memory Disorders; Neurons; Piloca | 2010 |
Changes in the numbers and distribution of calretinin in the epileptic rat hippocampus.
Topics: Analysis of Variance; Animals; Calbindin 2; Disease Models, Animal; Epilepsy; Gene Expression Regula | 2010 |
Comparative immunohistochemistry of synaptic markers in the rodent hippocampus in pilocarpine epilepsy.
Topics: Animals; Biomarkers; Epilepsy; GAP-43 Protein; Hippocampus; Immunohistochemistry; Male; Mice; Mice, | 2011 |
Perirhinal cortex hyperexcitability in pilocarpine-treated epileptic rats.
Topics: Action Potentials; Amygdala; Animals; Cell Polarity; Entorhinal Cortex; Epilepsy; Interneurons; Male | 2011 |
Tachycardias and sudden unexpected death in epilepsy: a gold rush by an experimental route.
Topics: Analysis of Variance; Animals; Death, Sudden; Disease Models, Animal; Electrocardiography; Epilepsy; | 2010 |
Chronic deficit in the expression of voltage-gated potassium channel Kv3.4 subunit in the hippocampus of pilocarpine-treated epileptic rats.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Down-Regulation; Epilepsy; Gene Expression; Hippocam | 2011 |
[Time course of COX-2 expression in hippocampus of the seizure rats].
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Epilepsy; Hippocampus; Male; Pilocarpine; Random | 2009 |
Characterization of spontaneous recurrent epileptiform discharges in hippocampal-entorhinal cortical slices prepared from chronic epileptic animals.
Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Electric S | 2011 |
[Astrocytic gap junction in the hippocampus of rats with lithium pilocarpine-induced epilepsy].
Topics: Animals; Astrocytes; Connexin 43; Epilepsy; Gap Junctions; Glial Fibrillary Acidic Protein; Hippocam | 2010 |
Contact size does not affect high frequency oscillation detection in intracerebral EEG recordings in a rat epilepsy model.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epileps | 2011 |
Diazoxide preconditioning against seizure-induced oxidative injury is via the PI3K/Akt pathway in epileptic rat.
Topics: Androstadienes; Animals; Decanoic Acids; Diazoxide; Epilepsy; Hydroxy Acids; Male; Malondialdehyde; | 2011 |
Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy.
Topics: Amino Acids; Animals; Carbamazepine; Convulsants; Drug Evaluation, Preclinical; Electroshock; Epilep | 2011 |
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Di | 2011 |
Investigations of hippocampal astrocytes in lipopolysaccharide-preconditioned rats in the pilocarpine model of epilepsy.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Hippocampus; Lipopolysaccharides; Male; Piloc | 2011 |
The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate.
Topics: Acetylcholinesterase; Animals; Curcumin; Epilepsy; Glutathione; Hippocampus; Lipid Peroxidation; Nig | 2011 |
Neuroglobin is up-regulated in the cerebellum of pups exposed to maternal epileptic seizures.
Topics: Animals; Animals, Newborn; Cerebellum; Epilepsy; Female; Glial Fibrillary Acidic Protein; Globins; H | 2011 |
A cell-free extract from human adipose stem cells protects mice against epilepsy.
Topics: Adipose Tissue; Animals; Animals, Newborn; Anticonvulsants; Blood-Brain Barrier; Cell Extracts; Cell | 2011 |
Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy.
Topics: Adolescent; Adult; Animals; Astrocytes; Child; Child, Preschool; Disease Models, Animal; Epilepsy; F | 2011 |
Chronically epileptic human and rat neocortex display a similar resistance against spreading depolarization in vitro.
Topics: Animals; Cortical Spreading Depression; Epilepsy; Humans; Male; Neocortex; Pilocarpine; Rats; Rats, | 2011 |
Early physical exercise and seizure susceptibility later in life.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Disease Models, Animal; Disease Susceptibility; Epile | 2011 |
Impaired mitochondrial biogenesis in hippocampi of rats with chronic seizures.
Topics: Animals; Chronic Disease; Disease Models, Animal; DNA, Mitochondrial; Down-Regulation; Epilepsy; Hip | 2011 |
Correlation study on expression of GST-π protein in brain tissue and peripheral blood of epilepsy rats induced by pilocarpine.
Topics: Animals; Anticonvulsants; Biomarkers; Brain; Drug Resistance; Epilepsy; Glutathione S-Transferase pi | 2011 |
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; | 2011 |
Investigating the role of zinc in a rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Hippocampus; Male; Pilocarpine | 2012 |
Increased expression of calponin-3 in epileptic patients and experimental rats.
Topics: Adolescent; Adult; Animals; Brain; Calcium-Binding Proteins; Calponins; Disease Models, Animal; Elec | 2012 |
Increased cholecystokinin labeling in the hippocampus of a mouse model of epilepsy maps to spines and glutamatergic terminals.
Topics: Animals; CA1 Region, Hippocampal; Cholecystokinin; Dendritic Spines; Epilepsy; Excitatory Postsynapt | 2012 |
Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 2011 |
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.
Topics: Action Potentials; Animals; Biophysics; Caveolin 1; Cell Line, Transformed; Disease Models, Animal; | 2011 |
Piperine protects epilepsy associated depression: a study on role of monoamines.
Topics: Alkaloids; Anhedonia; Animals; Anticonvulsants; Behavior, Animal; Benzodioxoles; Biogenic Monoamines | 2011 |
Upregulation of presynaptic mGluR2, but not mGluR3 in the epileptic medial perforant path.
Topics: Animals; Epilepsy; Male; Perforant Pathway; Pilocarpine; Presynaptic Terminals; Rats; Rats, Wistar; | 2012 |
Reduced ictogenic potential of 4-aminopyridine in the hippocampal region in the pilocarpine model of epilepsy.
Topics: 4-Aminopyridine; Animals; Epilepsy; Hippocampus; Neurons; Pilocarpine; Potassium Channel Blockers; R | 2012 |
Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A.
Topics: Animals; Bacopa; Cerebral Cortex; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Ex | 2012 |
Glial activation in a pilocarpine rat model for epileptogenesis: a morphometric and quantitative analysis.
Topics: Animals; Astrocytes; Cytoskeleton; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; Male; Neu | 2012 |
Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Aspartic Acid; Brain Mapping; Choline; Creatine; Disease Models, Animal; Epilepsy; Fluorode | 2012 |
Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.
Topics: Animals; Anticonvulsants; Benzoxazines; Brain; Brain Mapping; Diazepam; Disease Models, Animal; Epil | 2012 |
The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Epilepsy; Flavonoids; Lipid Peroxidation; Male; Neuroprotective | 2012 |
Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate.
Topics: Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Chromatography, High Press | 2012 |
Enhancement of asynchronous release from fast-spiking interneuron in human and rat epileptic neocortex.
Topics: Adolescent; Adult; Aged; Animals; Calcium; Child; Child, Preschool; Electrophysiological Phenomena; | 2012 |
Time-dependent modulation of mitogen activated protein kinases and AKT in rat hippocampus and cortex in the pilocarpine model of epilepsy.
Topics: Animals; Blotting, Western; Cerebral Cortex; Epilepsy; Hippocampus; Male; MAP Kinase Signaling Syste | 2012 |
Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Cycloheximide; Disease Models, Animal; Drug Interactions; Epilepsy; Hippoc | 2012 |
[Effect of serotonin depletion on seizures learning-memory in pilocarpine-induced epileptic rats].
Topics: 5,7-Dihydroxytryptamine; Animals; Epilepsy; Male; Maze Learning; Memory; Pilocarpine; Raphe Nuclei; | 2012 |
[Effects of Chinese herbal medicine Xifeng Capsule on multidrug resistance-associated protein 1 expression in hippocampus and cortex of rats with lithium-pilocarpine-induced epilepsy].
Topics: Animals; Cerebral Cortex; Drugs, Chinese Herbal; Epilepsy; Hippocampus; Lithium Compounds; Male; Mul | 2012 |
Patterns of the UP-Down state in normal and epileptic mice.
Topics: Action Potentials; Animals; Biophysics; Brain Waves; Dentate Gyrus; Electric Stimulation; Electroenc | 2012 |
Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis.
Topics: Animals; Convulsants; Epilepsy; Epilepsy, Absence; Excitatory Amino Acid Agonists; Excitatory Amino | 2012 |
The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cholinergic Agents; Convulsants; Electroencephalography; | 2013 |
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
Topics: Animals; Anticonvulsants; Biomarkers; Cell Hypoxia; Cerebral Cortex; Convulsants; Diazepam; Disease | 2013 |
A strength exercise program in rats with epilepsy is protective against seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Epilepsy; Male; Muscarinic Agonists; Muscle F | 2012 |
Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine.
Topics: 2-Aminoadipic Acid; Analysis of Variance; Animals; Astrocytes; Brain; Disease Models, Animal; Diseas | 2012 |
Protective role of astrocytic leptin signaling against excitotoxicity.
Topics: Animals; Astrocytes; Astrocytoma; Cell Line, Tumor; Convulsants; Epilepsy; Female; Gene Expression R | 2013 |
[Effect of acute stress stimulation on the seizure induction in epileptic model rats].
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Lithium Chloride; Pentylenetetrazole; P | 2012 |
Seizure-induced 5-HT release and chronic impairment of serotonergic function in rats.
Topics: Acute Disease; Animals; Brain; Chronic Disease; Electroencephalography; Epilepsy; Hippocampus; Hydro | 2013 |
Electrical stimulation of left anterior thalamic nucleus with high-frequency and low-intensity currents reduces the rate of pilocarpine-induced epilepsy in rats.
Topics: Animals; Anterior Thalamic Nuclei; Electric Stimulation Therapy; Epilepsy; Male; Pilocarpine; Rats; | 2013 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Effect on epileptogenesis of carbamazepine treatment during the silent period of the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Epilepsy; Hippocampus; Male; Pilocarpine; Rats | 2002 |
Determinants of ictal epileptiform patterns in the hippocampal slice.
Topics: Animals; Calcium; Calcium Channels, L-Type; Dantrolene; Electrophysiology; Enzyme Inhibitors; Epilep | 2002 |
Effect of topiramate following recurrent and prolonged seizures during early development.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Weight; Cell Death; Cognition; Convulsants; Disease | 2002 |
Effects of fluoxetine and TFMPP on spontaneous seizures in rats with pilocarpine-induced epilepsy.
Topics: Animals; Convulsants; Epilepsy; Fluoxetine; Male; Pilocarpine; Piperazines; Rats; Rats, Sprague-Dawl | 2002 |
Detection of late epilepsy by the texture analysis of MR brain images in the lithium-pilocarpine rat model.
Topics: Animals; Cerebral Cortex; Entorhinal Cortex; Epilepsy; Image Processing, Computer-Assisted; Lithium; | 2002 |
Overlapping microarray profiles of dentate gyrus gene expression during development- and epilepsy-associated neurogenesis and axon outgrowth.
Topics: Analysis of Variance; Animals; Antigens, CD; Atropine Derivatives; Axons; Calcium-Binding Proteins; | 2003 |
Respiratory pattern in a rat model of epilepsy.
Topics: Animals; Apnea; Blood Pressure; Chemoreceptor Cells; Convulsants; Epilepsy; Heart Rate; Hyperventila | 2003 |
Estradiol reduces seizure-induced hippocampal injury in ovariectomized female but not in male rats.
Topics: Animals; Epilepsy; Estradiol; Female; Hippocampus; Lithium; Male; Muscarinic Agonists; Neurons; Neur | 2003 |
Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Chronic Disease; Cortical Spreading Depression; D | 2003 |
Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Behavior, Animal; Cell Death; Disease Models, Animal | 2003 |
Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats.
Topics: Animals; Anticonvulsants; Cells, Cultured; Dentate Gyrus; Disease Models, Animal; Electric Stimulati | 2003 |
Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain.
Topics: Animals; Brain; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antago | 2003 |
In the lithium-pilocarpine model of epilepsy, brain lesions are not linked to changes in blood-brain barrier permeability: an autoradiographic study in adult and developing rats.
Topics: Age Factors; Animals; Autoradiography; Behavior, Animal; Blood Volume; Blood-Brain Barrier; Brain; D | 2003 |
Physical training does not influence interictal LCMRglu in pilocarpine-treated rats with epilepsy.
Topics: Animals; Blood Glucose; Brain; Brain Mapping; Carbon Radioisotopes; Deoxyglucose; Epilepsy; Physical | 2003 |
Long-term effects of early-life malnutrition and status epilepticus: assessment by spatial navigation and CREB(Serine-133) phosphorylation.
Topics: Animals; Animals, Newborn; Cell Death; Cyclic AMP Response Element-Binding Protein; Down-Regulation; | 2003 |
Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures.
Topics: Animals; Calcium-Binding Proteins; Calponins; Dendrites; Dentate Gyrus; Disease Models, Animal; Epil | 2003 |
Mice deficient for the extracellular matrix glycoprotein tenascin-r show physiological and structural hallmarks of increased hippocampal excitability, but no increased susceptibility to seizures in the pilocarpine model of epilepsy.
Topics: Animals; Astrocytes; Biomarkers; Calbindin 2; Cell Count; Convulsants; Disease Susceptibility; Elect | 2004 |
High-resolution in vivo imaging of hippocampal dendrites and spines.
Topics: Animals; Bicuculline; Dendrites; Electroencephalography; Epilepsy; GABA Antagonists; Green Fluoresce | 2004 |
Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Antagonists; Hippoca | 2004 |
Implementing a bioassay to screen molecules for antiepileptogenic activity: chronic pilocarpine versus subdudral haematoma models.
Topics: Animals; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy; Hematoma, Subdur | 2004 |
Normal spatial and contextual learning for ketamine-treated rats in the pilocarpine epilepsy model.
Topics: Animals; Disease Models, Animal; Epilepsy; Ketamine; Male; Maze Learning; Pilocarpine; Rats; Rats, W | 2004 |
Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy.
Topics: Animals; Brain; Cell Death; Cyclooxygenase 2; Cytokines; Demyelinating Diseases; Epilepsy; Gene Expr | 2004 |
Role of kinin B1 and B2 receptors in the development of pilocarpine model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knocko | 2004 |
Emergence of spontaneous seizures during the year following lithium/pilocarpine-induced epilepsy and neuronal loss within the right temporal cortices.
Topics: Animals; Cell Survival; Epilepsy; Functional Laterality; Lithium; Male; Nerve Degeneration; Neurons; | 2004 |
Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis.
Topics: Animals; Biological Transport; Brain-Derived Neurotrophic Factor; Cell Compartmentation; Convulsants | 2004 |
[Neuronal damage in the hippocampus of inbred mouse strains in the models of epilepsy induced by kainic acid and pilocarpine].
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred Strain | 2004 |
Fos induction and persistence, neurodegeneration, and interneuron activation in the hippocampus of epilepsy-resistant versus epilepsy-prone rats after pilocarpine-induced seizures.
Topics: Animals; Cell Count; Epilepsy; Genes, fos; Hippocampus; Immunohistochemistry; Interneurons; Muscarin | 2004 |
Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy.
Topics: Animals; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Postsynaptic Potentials; Hipp | 2004 |
Carbamazepine enhances discriminative memory in a rat model of epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Discrimination Learning; Disease Models, Animal; Drug Ad | 2004 |
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, | 2005 |
The mechanism of neuroprotection by topiramate in an animal model of epilepsy.
Topics: Animals; Brain; Cell Survival; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Dru | 2004 |
Epilepsy induced by extended amygdala-kindling in rats: lack of clear association between development of spontaneous seizures and neuronal damage.
Topics: Amygdala; Analysis of Variance; Animals; Cell Count; Differential Threshold; Disease Models, Animal; | 2004 |
Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Cross-Over Studies; Disease Models, Animal; Dose-Response | 2005 |
Expression of nestin in the hippocampal formation of rats submitted to the pilocarpine model of epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glial Fibri | 2005 |
Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Synergism; Epilepsy; Foc | 2005 |
A spontaneous recurrent seizure bioassay for anti-epileptogenic molecules.
Topics: Animals; Anticonvulsants; Biological Assay; Disease Models, Animal; Drug Evaluation, Preclinical; Ep | 2005 |
Electroacupuncture prevents cognitive deficits in pilocarpine-epileptic rats.
Topics: Animals; Cognition Disorders; Electroacupuncture; Epilepsy; Male; Maze Learning; Pilocarpine; Rats; | 2005 |
Anticonvulsant activity of androsterone and etiocholanolone.
Topics: 4-Aminopyridine; Androsterone; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; D | 2005 |
In vivo modulatory action of extracellular glutamate on the anticonvulsant effects of hippocampal dopamine and serotonin.
Topics: Animals; Anticonvulsants; Convulsants; Dopamine; Dopamine Antagonists; Epilepsy; Glutamic Acid; Hipp | 2005 |
Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats.
Topics: Afferent Pathways; Animals; Cell Differentiation; Cell Line; Cells, Cultured; Chronic Disease; Denta | 2005 |
Proechimys guyannensis: an animal model of resistance to epilepsy.
Topics: Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy; Hippo | 2005 |
[Qualitative study of hippocampal formation in hypertensive rats with epilepsy].
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Hippocampus; Hypertension; Male; Neurons; | 2005 |
Modifications in muscarinic, dopaminergic and serotonergic receptors concentrations in the hippocampus and striatum of epileptic rats.
Topics: Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Epilepsy; Hippocampus; Male; Pil | 2005 |
Ontogenetic profile of ectonucleotidase activities from brain synaptosomes of pilocarpine-treated rats.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine Triphosphatases; Age Factors; Analysis of Variance; | 2005 |
Studies of damage to hippocampal neurons in inbred mouse lines in models of epilepsy using kainic acid and pilocarpine.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Epilepsy; Hippocampus; HSP70 Heat-Shock Proteins; | 2005 |
[Analysis of cardiac parameters in animals with epilepsy: possible cause of sudden death?].
Topics: Animals; Death, Sudden; Disease Models, Animal; Electroencephalography; Epilepsy; Heart Rate; Male; | 2005 |
Functional properties and oxidative modulation of A-type K currents in hippocampal granule cells of control and chronically epileptic rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Impedance; Electric | 2006 |
Characterization of cortical spreading depression in adult well-nourished and malnourished rats submitted to the association of pilocarpine-induced epilepsy plus streptozotocin-induced hyperglycemia.
Topics: Animals; Association; Cortical Spreading Depression; Electroencephalography; Epilepsy; Hyperglycemia | 2006 |
Pro-epileptic effect of alfentanil in rats subjected to pilocarpine-induced chronic epilepsy.
Topics: Alfentanil; Animals; Brain; Chronic Disease; Convulsants; Disease Models, Animal; Dose-Response Rela | 2006 |
Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy.
Topics: Adenosine Triphosphatases; Animals; Astrocytes; Brain; Convulsants; Dentate Gyrus; Disease Models, A | 2006 |
Unexpected expression of orexin-B in basal conditions and increased levels in the adult rat hippocampus during pilocarpine-induced epileptogenesis.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Cell Count; Disease Models, Animal; Dr | 2006 |
Differential paired-pulse responses between the CA1 region and the dentate gyrus are related to altered CLC-2 immunoreactivity in the pilocarpine-induced rat epilepsy model.
Topics: Action Potentials; Animals; Chloride Channels; CLC-2 Chloride Channels; Convulsants; Dentate Gyrus; | 2006 |
Cell domain-dependent changes in the glutamatergic and GABAergic drives during epileptogenesis in the rat CA1 region.
Topics: Algorithms; Animals; Dendrites; Electrodes, Implanted; Electroencephalography; Electrophysiology; Ep | 2007 |
Mitochondrial dysfunction and ultrastructural damage in the hippocampus of pilocarpine-induced epileptic rat.
Topics: Animal Diseases; Animals; Blotting, Western; Electron Transport Complex IV; Epilepsy; Gene Expressio | 2007 |
Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat.
Topics: Animals; Anticonvulsants; Brain Damage, Chronic; Carbamazepine; Convulsants; Disease Models, Animal; | 2006 |
Effects of different types of physical exercise on the staining of parvalbumin-positive neurons in the hippocampal formation of rats with epilepsy.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Epilepsy; Hippo | 2007 |
Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; A | 2007 |
Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Dentate Gyrus; Disease | 2007 |
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Down-Regulation; Epilepsy; Epilepsy, Temporal Lobe; Ge | 2007 |
Loss of input from the mossy cells blocks maturation of newly generated granule cells.
Topics: Animals; Anticonvulsants; Biomarkers; Bromodeoxyuridine; Calbindin 2; Cell Differentiation; Cell Pro | 2007 |
[Correlation between hippocampal mossy fiber sprouting and synaptic reorganization and mechanisms of temporal lobe epilepsy].
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; In Situ Hybridization; Lithium C | 2007 |
Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures.
Topics: Action Potentials; Animals; Biomarkers; Calbindins; Calcitonin Gene-Related Peptide; Choristoma; Con | 2007 |
Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy.
Topics: Animals; Benzodiazepines; Dendrites; Dentate Gyrus; Desoxycorticosterone; Epilepsy; Male; Mice; Mice | 2007 |
Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells.
Topics: Animals; Axons; Cell Death; Cell Division; Cell Movement; Cellular Senescence; Dendrites; Dentate Gy | 2007 |
Newly generated granule cells show rapid neuroplastic changes in the adult rat dentate gyrus during the first five days following pilocarpine-induced seizures.
Topics: Age Factors; Animals; Biomarkers; Cell Count; Cell Differentiation; Cell Proliferation; Convulsants; | 2007 |
Glutamate binding is altered in hippocampus and cortex of Wistar rats after pilocarpine-induced Status Epilepticus.
Topics: Animals; Binding Sites; Cerebral Cortex; Convulsants; Epilepsy; Glutamic Acid; Hippocampus; Ligands; | 2007 |
[Synchronization analysis of ECoG and EHG from eplieptiform discharges rats].
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsy; Hippocampus; Male; Pilocarpine; Rats; Ra | 2007 |
Increased P-glycoprotein expression and decreased phenobarbital distribution in the brain of pentylenetetrazole-kindled rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Brain; Brain Ch | 2007 |
Reduced spike-timing reliability correlates with the emergence of fast ripples in the rat epileptic hippocampus.
Topics: Animals; Data Interpretation, Statistical; Delayed Rectifier Potassium Channels; Electrophysiology; | 2007 |
Hyperexcitability of the CA1 hippocampal region during epileptogenesis.
Topics: Action Potentials; Animals; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Ele | 2007 |
BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae.
Topics: Alternative Splicing; Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Dendrites; E | 2008 |
Sigma 1 receptor-mediated increase in hippocampal extracellular dopamine contributes to the mechanism of the anticonvulsant action of neuropeptide Y.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Chromatography, High Pressure Liqu | 2007 |
Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy.
Topics: Animals; Channelopathies; Cyclic Nucleotide-Gated Cation Channels; Dendrites; Disease Models, Animal | 2007 |
Acute induction of epileptiform discharges by pilocarpine in the in vitro isolated guinea-pig brain requires enhancement of blood-brain barrier permeability.
Topics: Acute Disease; Animals; Blood-Brain Barrier; Brain; Dose-Response Relationship, Drug; Epilepsy; Evok | 2008 |
Decreased glutamate receptor binding and NMDA R1 gene expression in hippocampus of pilocarpine-induced epileptic rats: neuroprotective role of Bacopa monnieri extract.
Topics: Analysis of Variance; Animals; Bacopa; Behavior, Animal; Disease Models, Animal; Dose-Response Relat | 2008 |
Network hyperexcitability within the deep layers of the pilocarpine-treated rat entorhinal cortex.
Topics: Action Potentials; Animals; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epileps | 2008 |
Neuroprotective effect caused by MPEP, an antagonist of metabotropic glutamate receptor mGluR5, on seizures induced by pilocarpine in 21-day-old rats.
Topics: Acetylcholinesterase; Animals; Brain; Convulsants; Cytoprotection; Disease Models, Animal; Dose-Resp | 2008 |
Neuroprotective activity of omega-3 fatty acids against epilepsy-induced hippocampal damage: Quantification with immunohistochemical for calcium-binding proteins.
Topics: Analysis of Variance; Animals; Brain Injuries; Calbindin 2; Cell Count; Disease Models, Animal; Epil | 2008 |
Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats.
Topics: Acetylcholine; Acetylcholinesterase; Alternative Splicing; Animals; Chronic Disease; Convulsants; El | 2008 |
Zinc transporter 3 immunohistochemical tracing of sprouting mossy fibres.
Topics: Animals; Blotting, Western; Carrier Proteins; Cation Transport Proteins; Epilepsy; Immunohistochemis | 2008 |
Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats.
Topics: Animals; Benzamides; Blotting, Western; Brain Injuries; CD40 Antigens; Central Nervous System Diseas | 2008 |
Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats.
Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Atropine; Biomarkers; Bone Resorption; Disease Model | 2008 |
Decrease of neurotrophin-3 mRNA in adult rat hippocampus after pilocarpine seizures.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; In Situ Hybridization; Male; Nerve Growth Fa | 1995 |
Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats.
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy; Hippocampus; Histocytochemistr | 1995 |
Kainic acid, bicuculline, pentylenetetrazol and pilocarpine elicit maximal dentate activation in the anesthetized rat.
Topics: Anesthesia; Animals; Bicuculline; Convulsants; Electric Stimulation; Epilepsy; Evoked Potentials; Hi | 1994 |
Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures.
Topics: Amino Acids; Animals; Behavior, Animal; Dialysis; Dicarboxylic Acids; Epilepsy; Glutamates; Glutamic | 1993 |
Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Felbam | 1993 |
Expression of c-fos protein in the experimental epilepsy induced by pilocarpine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Brain; Dose-Respo | 1993 |
Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy.
Topics: Animals; Dinoprost; Dinoprostone; Disease Models, Animal; Epilepsy; Hippocampus; Male; Muscarinic Ag | 1995 |
Epileptiform activity induced by pilocarpine in the rat hippocampal-entorhinal slice preparation.
Topics: Animals; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Hippocam | 1996 |
The pilocarpine model of epilepsy in mice.
Topics: Animals; Coloring Agents; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; E | 1996 |
Demands during maze. learning in limbic epileptic rats: selective damage in the thalamus?
Topics: Animals; Attention; Brain Mapping; Cell Count; Epilepsy; Limbic System; Lithium; Male; Maze Learning | 1996 |
Disruption of light-induced c-Fos immunoreactivity in the suprachiasmatic nuclei of chronic epileptic rats.
Topics: Animals; Antibody Specificity; Benzoxazines; Chronic Disease; Circadian Rhythm; Coloring Agents; Epi | 1996 |
Developmental aspects of the pilocarpine model of epilepsy.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Disease Models, Animal; Epilepsy; Male; Pilocarpine; | 1996 |
Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures.
Topics: Animals; Brain; Epilepsy; Female; Hippocampus; Interneurons; Limbic System; Male; Pilocarpine; Rats; | 1996 |
Blockade of spreading depression in chronic epileptic rats: reversion by diazepam.
Topics: Animals; Anticonvulsants; Chronic Disease; Cortical Spreading Depression; Diazepam; Electroencephalo | 1997 |
Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats.
Topics: Animals; Cycloheximide; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy; Excitatory A | 1997 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Membrane time constant as a tool to assess cell degeneration.
Topics: Animals; Cell Membrane; Dendrites; Dentate Gyrus; Electric Conductivity; Electric Impedance; Epileps | 1997 |
Interictal and ictal activity in the rat cobalt/pilocarpine model of epilepsy decreased by local perfusion of diazepam.
Topics: Animals; Anticonvulsants; Cobalt; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy | 1997 |
NMDA receptor activation during status epilepticus is required for the development of epilepsy.
Topics: Animals; Cell Count; Dizocilpine Maleate; Electroencephalography; Epilepsy; Excitatory Amino Acid An | 1998 |
Ictal epileptiform activity in the CA3 region of hippocampal slices produced by pilocarpine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Epilepsy; Extracellular Space; GABA Agonist | 1998 |
Persistent elevation of nocturnal activity in rodents following apparent recovery from lithium/pilocarpine-induced limbic seizures.
Topics: Animals; Behavior, Animal; Brain; Circadian Rhythm; Epilepsy; Limbic System; Lithium; Male; Melatoni | 1998 |
Geophysical variables and behavior: LXXXIV. Quantitative increases in group aggression in male epileptic rats during increases in geomagnetic activity.
Topics: Aggression; Animals; Behavior, Animal; Epilepsy; Geography; Limbic System; Lithium; Magnetics; Male; | 1998 |
Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy.
Topics: Animals; Epilepsy; Estradiol; Estrus; Female; Fertility; Follicle Stimulating Hormone; Humans; Lutei | 1998 |
Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: a qualitative study.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Electro | 1998 |
Modulation of GABAA receptor-mediated inhibition by postsynaptic calcium in epileptic hippocampal neurons.
Topics: Animals; Calcium; Chelating Agents; Electric Stimulation; Epilepsy; Epilepsy, Temporal Lobe; Hippoca | 1998 |
Persistence and atrophy of septal/diagonal band neurons expressing the p75 neurotrophin receptor in pilocarpine-induced chronic epilepsy in the rat.
Topics: Animals; Antibodies; Atrophy; Cholinergic Fibers; Chronic Disease; Epilepsy; Hippocampus; Male; Neur | 1998 |
Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic epilepsy.
Topics: Animals; Epilepsy; Male; Mossy Fibers, Hippocampal; Muscarinic Agonists; Pilocarpine; Rats; Rats, Sp | 1998 |
Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine.
Topics: Acetylcholine; Animals; Behavior, Animal; Brain Chemistry; Brain-Derived Neurotrophic Factor; Carbac | 1999 |
The course of untreated seizures in the pilocarpine model of epilepsy.
Topics: Animals; Behavior, Animal; Disease Progression; Electroencephalography; Epilepsy; Incidence; Muscari | 1999 |
Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus.
Topics: Action Potentials; Animals; Brain-Derived Neurotrophic Factor; Cell Size; Epilepsy; Excitatory Posts | 1999 |
Electroencephalographic study of the effect of neurotoxin DSP-4 in iron model of chronic focal epilepsy.
Topics: Animals; Benzylamines; Cerebral Cortex; Chlorides; Electroencephalography; Epilepsy; Ferric Compound | 1999 |
Selective alterations of glycosaminoglycans synthesis and proteoglycan expression in rat cortex and hippocampus in pilocarpine-induced epilepsy.
Topics: Animals; Cerebral Cortex; Chondroitin Sulfates; Epilepsy; Glycosaminoglycans; Heparitin Sulfate; Hip | 1999 |
Increased sensitivity to seizures in mice lacking cellular prion protein.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knoc | 1999 |
Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Central Nervous System Sti | 2000 |
Plasticity of excitatory amino acid transporters in experimental epilepsy.
Topics: Animals; Dicarboxylic Acids; Epilepsy; Female; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; N | 2000 |
Regional and subunit-specific downregulation of acid-sensing ion channels in the pilocarpine model of epilepsy.
Topics: Acid Sensing Ion Channels; Amino Acid Sequence; Animals; Blotting, Northern; Convulsants; DNA Probes | 2001 |
Activity-induced expression of common reference genes in individual cns neurons.
Topics: Actins; Animals; Central Nervous System; Convulsants; Cyclophilin A; Epilepsy; Gene Expression; Glyc | 2001 |
Agonistic behavior in groups of limbic epileptic male rats: pattern of brain damage and moderating effects from normal rats.
Topics: Agonistic Behavior; Animals; Antimanic Agents; Behavior, Animal; Brain Injuries; Cerebral Cortex; Co | 2001 |
The spiny rat Proechimys guyannensis as model of resistance to epilepsy: chemical characterization of hippocampal cell populations and pilocarpine-induced changes.
Topics: Animals; Calbindin 2; Calbindins; Cell Count; Disease Models, Animal; Epilepsy; Glutamate Decarboxyl | 2001 |
Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats.
Topics: Animals; Chronic Disease; Epilepsy; Glutathione Peroxidase; Hippocampus; Hydrogen Peroxide; Male; Mu | 2001 |
Chronic inhibition of cortex microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake in the rat pilocarpine model following epileptogenesis.
Topics: Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium Channel Blockers; Cerebral Cortex; Epilepsy; Immunol | 2001 |
Dopamine D2 receptor signaling controls neuronal cell death induced by muscarinic and glutamatergic drugs.
Topics: Acetylcholine; Animals; Behavior, Animal; Cell Death; Dose-Response Relationship, Drug; Epilepsy; Ex | 2002 |
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsy.
Topics: Acetylcholine; Action Potentials; Aggression; Animals; Behavior, Animal; Brain; Chronic Disease; Dis | 2002 |
Inhibitory role of the zona incerta in the pilocarpine model of epilepsy.
Topics: Animals; Bicuculline; Brain Mapping; Disease Models, Animal; Electroencephalography; Epilepsy; GABA | 2002 |
Seizure-dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus.
Topics: Animals; Cell Respiration; Cells, Cultured; Chronic Disease; DNA, Mitochondrial; Down-Regulation; El | 2002 |
Castration in female rats modifies the development of the pilocarpine model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Ovariectomy; Pilocarpine; Rats; Rats | 2002 |
Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures.
Topics: Action Potentials; Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2002 |
ACTH: a structure-activity study on pilocarpine-induced epilepsy.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Dose-R | 1992 |
Excitatory neurotransmitters in the lateral habenula and pedunculopontine nucleus of rat modulate limbic seizures induced by pilocarpine.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Electroencepha | 1992 |
Dopaminergic regulation of epileptic activity.
Topics: Animals; Dopamine; Dopamine Agonists; Dopamine Antagonists; Epilepsy; Injections; Male; Pilocarpine; | 1992 |
NMDA receptor-mediated excitability in dendritically deformed dentate granule cells in pilocarpine-treated rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dendrites; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; I | 1991 |
Seizures increase acetylcholine and choline concentrations in rat brain regions.
Topics: Acetylcholine; Animals; Brain; Choline; Epilepsy; Kainic Acid; Lithium; Male; Pilocarpine; Rats; Rat | 1991 |
Opposite effects of stimulation of D1 and D2 dopamine receptors on the expression of motor seizures in mouse and rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Dopamine Agents; | 1990 |
Cholinergic and adrenergic agents modify the initiation and termination of epileptic discharges in the dentate gyrus.
Topics: Animals; Atropine; Clonidine; Electric Stimulation; Epilepsy; Hippocampus; Male; Parasympathomimetic | 1991 |
Some evidence that intrahippocampal grafting of noradrenergic neurons suppresses spontaneous seizures in epileptic rats.
Topics: Adrenergic Fibers; Animals; Epilepsy; Hippocampus; Locus Coeruleus; Male; Pilocarpine; Random Alloca | 1990 |
Lithium enhances neuronal muscarinic excitation by presynaptic facilitation.
Topics: Animals; Drug Interactions; Electrophysiology; Epilepsy; In Vitro Techniques; Lithium; Male; Muscari | 1990 |
The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Epilepsy; Male; M | 1989 |
Paradoxical anticonvulsant activity of the excitatory amino acid N-methyl-D-aspartate in the rat caudate-putamen.
Topics: Animals; Anticonvulsants; Aspartic Acid; Caudate Nucleus; Epilepsy; Ibotenic Acid; Male; N-Methylasp | 1987 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; | 1971 |
Sensitivity of denervated cerebral cortex to cholinomimetics.
Topics: Animals; Atropine; Bethanechol Compounds; Carbachol; Cats; Cerebral Cortex; Cholinesterases; Denerva | 1972 |
Various physical parameters which influence photosensitive epilepsy in the Papio papio.
Topics: Animals; Dilatation; Electroencephalography; Epilepsy; Female; Filtration; Haplorhini; Light; Male; | 1973 |