pilocarpine has been researched along with Astrocytosis in 38 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Initially, hippocampal slices were obtained from sham rats and rats subjected to the Li-pilocarpine model of epilepsy, at 1, 14, and 56 days after status epilepticus (SE), which correspond to the acute, silent, and chronic phases." | 7.88 | Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis. ( de Oliveira, DL; Gonçalves, CA; Hansen, F; Leite, MC; Negri, E; Vizuete, AFK, 2018) |
| "The status epilepticus (SE) induced by lithium-pilocarpine is a well characterized rodent model of the human temporal lobe epilepsy (TLE) which is accompanied by severe brain damage." | 7.85 | Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model. ( Bankstahl, JP; Bascuñana, P; Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MA; Shiha, AA; Silván, Á, 2017) |
| "It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium-pilocarpine model of status epilepticus (SE) in rats." | 7.83 | Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2016) |
| "The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period." | 7.79 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| " Therefore, the present study investigated the temporal pattern of KLF6 expression in the mouse hippocampus and identified cell types expressing KLF6 after pilocarpine-induced status epilepticus (SE)." | 7.77 | Upregulation of Krüppel-like factor 6 in the mouse hippocampus after pilocarpine-induced status epilepticus. ( Cho, KO; Jeong, KH; Kim, SY; Lee, KE, 2011) |
| "Status epilepticus (SE) models were established by intraperitoneal injection of pilocarpine." | 7.75 | ERK1/2 activation in reactive astrocytes of mice with pilocarpine-induced status epilepticus. ( Chen, YM; Li, YQ; Liu, H; Xu, J; Xu, ZC; Xue, T, 2009) |
| " In this study, we assessed changes in vascular structure, gene expression, and the time course of neuronal degeneration in the cerebral cortex during the acute period after onset of pilocarpine-induced status epilepticus (SE)." | 7.74 | Pilocarpine-induced status epilepticus in rats involves ischemic and excitotoxic mechanisms. ( Benati, D; Bernardi, P; Fabene, PF; Farace, P; Galiè, M; Marzola, P; Merigo, F; Nicolato, E; Sbarbati, A, 2007) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 7.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| " In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2h during pilocarpine induced status epilepticus, and never recovered." | 7.73 | Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. ( Burgunder, JM; Chang, ML; Chia, SC; Ma, DL; Probst, A; Tang, FR; Tang, YC, 2006) |
| "Significant reduction in glutamate receptor 1 (GluR1)- and GluR2/3-immunopositive neurons was demonstrated in the hilus of the dentate gyrus in mice killed on days 1, 7 and 60 after pilocarpine-induced status epilepticus (PISE)." | 7.73 | Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus. ( Chen, PM; Chia, SC; Gao, H; Khanna, S; Lee, WL; Liu, CP; Tang, FR; Zhang, S, 2005) |
| "The expression of metabotropic glutamate receptor 8 (mGluR8) was studied in the rat hippocampus after pilocarpine-induced status epilepticus (APISE) by light immunohistochemistry and immunoelectron microscopy." | 7.71 | Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus. ( Lee, WL; Ling, EA; Sim, MK; Tang, FR; Yang, J, 2001) |
| "Epilepsy is one of the most common neurologic diseases, and around 30% of all epilepsies, particularly the temporal lobe epilepsy (TLE), are highly refractory to current pharmacological treatments." | 5.91 | A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes. ( Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á, 2023) |
| "Pilocarpine was administered systemically (380mg/kg i." | 5.31 | Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus. ( Capek, R; De Koninck, Y; Poirier, JL, 2000) |
| " Our further findings revealed that treatment with SR9009 inhibited NLRP3 inflammasome activation, inflammatory cytokine (IL-1β, IL-18, IL-6, and TNF-α) production, astrocytosis, microgliosis, and neuronal damage in the hippocampus after SE." | 3.96 | Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model. ( He, J; Liu, S; Shen, K; Wei, Y; Wu, K; Yang, H; Yang, X; Yue, J; Zhang, C, 2020) |
| " In the present study, we found that PEA15 was distinctly phosphorylated in reactive astrocytes and apoptotic astrocytes in the rat hippocampus following LiCl-pilocarpine-induced status epilepticus (SE, a prolonged seizure activity)." | 3.88 | The differential roles of PEA15 phosphorylations in reactive astrogliosis and astroglial apoptosis following status epilepticus. ( Kang, TC; Park, JY, 2018) |
| "Initially, hippocampal slices were obtained from sham rats and rats subjected to the Li-pilocarpine model of epilepsy, at 1, 14, and 56 days after status epilepticus (SE), which correspond to the acute, silent, and chronic phases." | 3.88 | Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis. ( de Oliveira, DL; Gonçalves, CA; Hansen, F; Leite, MC; Negri, E; Vizuete, AFK, 2018) |
| "The status epilepticus (SE) induced by lithium-pilocarpine is a well characterized rodent model of the human temporal lobe epilepsy (TLE) which is accompanied by severe brain damage." | 3.85 | Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model. ( Bankstahl, JP; Bascuñana, P; Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MA; Shiha, AA; Silván, Á, 2017) |
| "It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium-pilocarpine model of status epilepticus (SE) in rats." | 3.83 | Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2016) |
| "The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period." | 3.79 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| "Both proconvulsive and anticonvulsive roles of leptin have been reported, suggesting cell-specific actions of leptin in different models of seizure and epilepsy." | 3.79 | Protective role of astrocytic leptin signaling against excitotoxicity. ( Hsuchou, H; Jayaram, B; Kastin, AJ; Khan, RS; Pan, W; Wu, X, 2013) |
| " Therefore, the present study investigated the temporal pattern of KLF6 expression in the mouse hippocampus and identified cell types expressing KLF6 after pilocarpine-induced status epilepticus (SE)." | 3.77 | Upregulation of Krüppel-like factor 6 in the mouse hippocampus after pilocarpine-induced status epilepticus. ( Cho, KO; Jeong, KH; Kim, SY; Lee, KE, 2011) |
| "Levetiracetam (LEV, 2S-(oxo-1-pyrrolidinyl)butanamide, Keppra, UCB Pharma) is a new anti-epileptic drug used to treat certain types of seizures in epilepsy patients." | 3.76 | Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. ( Choi, HC; Choi, SY; Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Song, HK, 2010) |
| "Status epilepticus (SE) models were established by intraperitoneal injection of pilocarpine." | 3.75 | ERK1/2 activation in reactive astrocytes of mice with pilocarpine-induced status epilepticus. ( Chen, YM; Li, YQ; Liu, H; Xu, J; Xu, ZC; Xue, T, 2009) |
| " In this study, we assessed changes in vascular structure, gene expression, and the time course of neuronal degeneration in the cerebral cortex during the acute period after onset of pilocarpine-induced status epilepticus (SE)." | 3.74 | Pilocarpine-induced status epilepticus in rats involves ischemic and excitotoxic mechanisms. ( Benati, D; Bernardi, P; Fabene, PF; Farace, P; Galiè, M; Marzola, P; Merigo, F; Nicolato, E; Sbarbati, A, 2007) |
| "Significant reduction in glutamate receptor 1 (GluR1)- and GluR2/3-immunopositive neurons was demonstrated in the hilus of the dentate gyrus in mice killed on days 1, 7 and 60 after pilocarpine-induced status epilepticus (PISE)." | 3.73 | Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus. ( Chen, PM; Chia, SC; Gao, H; Khanna, S; Lee, WL; Liu, CP; Tang, FR; Zhang, S, 2005) |
| " In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2h during pilocarpine induced status epilepticus, and never recovered." | 3.73 | Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. ( Burgunder, JM; Chang, ML; Chia, SC; Ma, DL; Probst, A; Tang, FR; Tang, YC, 2006) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 3.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| "The rodent pilocarpine model of epilepsy exhibits hippocampal sclerosis and spontaneous seizures and thus resembles human temporal lobe epilepsy." | 3.72 | Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. ( Almonte, AG; Borges, K; Dingledine, R; Gearing, M; McDermott, DL; Smith, AB; Wainer, BH, 2003) |
| "For half of the animals (nine of 17) subject to pilocarpine-induced status epilepticus (SE), when assessed 60 days later, variable levels of reactive astrocytes were seen in many thalamic, hippocampal, amygdalar, and neocortical areas." | 3.71 | Characterization of reactive astrocytes in the chronic phase of the pilocarpine model of epilepsy. ( Garzillo, CL; Mello, LE, 2002) |
| "The expression of metabotropic glutamate receptor 8 (mGluR8) was studied in the rat hippocampus after pilocarpine-induced status epilepticus (APISE) by light immunohistochemistry and immunoelectron microscopy." | 3.71 | Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus. ( Lee, WL; Ling, EA; Sim, MK; Tang, FR; Yang, J, 2001) |
| "After 3 hr of stage 5 acute seizure, hippocampal astrocytes show increased intrinsic calcium activity in stratum radiatum as well as reactive astrogliosis in the stratum lacunosum moleculare and hilus regions of the hippocampus." | 1.91 | Pilocarpine-induced acute seizure causes rapid area-specific astrogliosis and alters purinergic signaling in rat hippocampus. ( Harshad, PA; Joshi, NB; Joshi, PG; Singh, M; Tewari, BP, 2023) |
| "Epilepsy is one of the most common neurologic diseases, and around 30% of all epilepsies, particularly the temporal lobe epilepsy (TLE), are highly refractory to current pharmacological treatments." | 1.91 | A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes. ( Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á, 2023) |
| "Long-term ANT-DBS significantly reduced seizure generalization in pilocarpine-induced epileptic rats." | 1.91 | Long-term ANT-DBS effects in pilocarpine-induced epileptic rats: A combined 9.4T MRI and histological study. ( Deng, J; Gao, JH; Guan, Y; Jing, B; Li, T; Liang, X; Luan, G; Tang, C; Wang, X; Xie, P; Xu, K; Zhou, J, 2023) |
| "Then, spontaneous recurrent seizures (SRS), neuronal loss and astrogliosis were assessed." | 1.51 | The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy. ( Chen, Y; Sun, M; van Luijtelaar, G; Wang, J; Wang, Q, 2019) |
| "However, whether STAT3 controls astrogliosis in epilepsy is not clear." | 1.37 | Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy. ( Chen, Y; Fang, M; Lei, X; Li, Y; Wang, L; Wang, X; Xie, Y; Xu, P; Xu, Z; Xue, T; Zhang, J; Zhang, Z, 2011) |
| "Pilocarpine was administered systemically (380mg/kg i." | 1.31 | Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus. ( Capek, R; De Koninck, Y; Poirier, JL, 2000) |
| "Cell death, reactive gliosis, and axonal sprouting are among the best studied alterations in the epileptic brain." | 1.30 | Differential regulation of cytokine expression following pilocarpine-induced seizure. ( Jankowsky, JL; Patterson, PH, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 14 (36.84) | 29.6817 |
| 2010's | 16 (42.11) | 24.3611 |
| 2020's | 7 (18.42) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, K | 1 |
| Xie, P | 1 |
| Deng, J | 1 |
| Tang, C | 1 |
| Wang, X | 2 |
| Guan, Y | 1 |
| Zhou, J | 1 |
| Li, T | 1 |
| Liang, X | 1 |
| Jing, B | 1 |
| Gao, JH | 1 |
| Luan, G | 1 |
| Hernández-Martín, N | 1 |
| Gomez, F | 2 |
| Silván, Á | 2 |
| Rosa, RF | 1 |
| Delgado, M | 3 |
| Bascuñana, P | 3 |
| Pozo, MÁ | 3 |
| García-García, L | 3 |
| Tewari, BP | 1 |
| Harshad, PA | 1 |
| Singh, M | 1 |
| Joshi, NB | 1 |
| Joshi, PG | 1 |
| Yue, J | 1 |
| He, J | 1 |
| Wei, Y | 1 |
| Shen, K | 1 |
| Wu, K | 1 |
| Yang, X | 1 |
| Liu, S | 1 |
| Zhang, C | 1 |
| Yang, H | 1 |
| Santillán-Cigales, JJ | 1 |
| Mercado-Gómez, OF | 1 |
| Arriaga-Ávila, V | 1 |
| Landgrave-Gómez, J | 1 |
| Guevara-Guzmán, R | 1 |
| Rojas, A | 1 |
| Amaradhi, R | 1 |
| Banik, A | 1 |
| Jiang, C | 1 |
| Abreu-Melon, J | 1 |
| Wang, S | 1 |
| Dingledine, R | 2 |
| Ganesh, T | 1 |
| Sano, F | 1 |
| Shigetomi, E | 1 |
| Shinozaki, Y | 1 |
| Tsuzukiyama, H | 1 |
| Saito, K | 1 |
| Mikoshiba, K | 1 |
| Horiuchi, H | 1 |
| Cheung, DL | 1 |
| Nabekura, J | 1 |
| Sugita, K | 1 |
| Aihara, M | 1 |
| Koizumi, S | 1 |
| Shiha, AA | 2 |
| Fernández de la Rosa, R | 2 |
| Bankstahl, JP | 1 |
| Park, JY | 1 |
| Kang, TC | 3 |
| Vizuete, AFK | 1 |
| Hansen, F | 1 |
| Negri, E | 1 |
| Leite, MC | 1 |
| de Oliveira, DL | 1 |
| Gonçalves, CA | 1 |
| Wang, J | 1 |
| Chen, Y | 2 |
| Wang, Q | 1 |
| van Luijtelaar, G | 1 |
| Sun, M | 1 |
| Brewster, AL | 1 |
| Lugo, JN | 1 |
| Patil, VV | 1 |
| Lee, WL | 3 |
| Qian, Y | 1 |
| Vanegas, F | 1 |
| Anderson, AE | 1 |
| Vargas, JR | 1 |
| Takahashi, DK | 1 |
| Thomson, KE | 1 |
| Wilcox, KS | 1 |
| Rossi, AR | 1 |
| Angelo, MF | 1 |
| Villarreal, A | 1 |
| Lukin, J | 1 |
| Ramos, AJ | 1 |
| de Cristóbal, J | 1 |
| Lima, IVA | 1 |
| Campos, AC | 1 |
| Bellozi, PMQ | 1 |
| Doria, JG | 1 |
| Ribeiro, FM | 1 |
| Moraes, MFD | 1 |
| de Oliveira, ACP | 1 |
| Marchi, N | 1 |
| Fan, Q | 1 |
| Ghosh, C | 1 |
| Fazio, V | 1 |
| Bertolini, F | 1 |
| Betto, G | 1 |
| Batra, A | 1 |
| Carlton, E | 1 |
| Najm, I | 1 |
| Granata, T | 1 |
| Janigro, D | 1 |
| Kim, JE | 2 |
| Kwak, SE | 1 |
| Jo, SM | 2 |
| Li, YQ | 1 |
| Xue, T | 2 |
| Xu, J | 1 |
| Xu, ZC | 1 |
| Liu, H | 1 |
| Chen, YM | 1 |
| Choi, HC | 1 |
| Song, HK | 1 |
| Kim, DS | 1 |
| Choi, SY | 1 |
| Kim, YI | 1 |
| Auvin, S | 1 |
| Mazarati, A | 1 |
| Shin, D | 1 |
| Sankar, R | 1 |
| Jeong, KH | 1 |
| Lee, KE | 1 |
| Kim, SY | 1 |
| Cho, KO | 1 |
| Isaev, D | 1 |
| Zhao, Q | 1 |
| Kleen, JK | 1 |
| Lenck-Santini, PP | 1 |
| Adstamongkonkul, D | 1 |
| Isaeva, E | 1 |
| Holmes, GL | 1 |
| Xu, Z | 1 |
| Zhang, Z | 1 |
| Xu, P | 1 |
| Zhang, J | 1 |
| Lei, X | 1 |
| Li, Y | 1 |
| Xie, Y | 1 |
| Wang, L | 1 |
| Fang, M | 1 |
| do Nascimento, AL | 1 |
| Dos Santos, NF | 1 |
| Campos Pelágio, F | 1 |
| Aparecida Teixeira, S | 1 |
| de Moraes Ferrari, EA | 1 |
| Langone, F | 1 |
| Jayaram, B | 1 |
| Khan, RS | 1 |
| Kastin, AJ | 1 |
| Hsuchou, H | 1 |
| Wu, X | 1 |
| Pan, W | 1 |
| Garzillo, CL | 1 |
| Mello, LE | 1 |
| Borges, K | 1 |
| Gearing, M | 1 |
| McDermott, DL | 1 |
| Smith, AB | 1 |
| Almonte, AG | 1 |
| Wainer, BH | 1 |
| Fasen, K | 1 |
| Elger, CE | 1 |
| Lie, AA | 1 |
| Tang, FR | 3 |
| Chia, SC | 2 |
| Zhang, S | 1 |
| Chen, PM | 1 |
| Gao, H | 1 |
| Liu, CP | 1 |
| Khanna, S | 1 |
| Ma, DL | 1 |
| Tang, YC | 1 |
| Chang, ML | 1 |
| Probst, A | 1 |
| Burgunder, JM | 1 |
| Chakir, A | 1 |
| Fabene, PF | 2 |
| Ouazzani, R | 1 |
| Bentivoglio, M | 1 |
| Lively, S | 1 |
| Brown, IR | 1 |
| Merigo, F | 1 |
| Galiè, M | 1 |
| Benati, D | 1 |
| Bernardi, P | 1 |
| Farace, P | 1 |
| Nicolato, E | 1 |
| Marzola, P | 1 |
| Sbarbati, A | 1 |
| Jankowsky, JL | 1 |
| Patterson, PH | 1 |
| Poirier, JL | 1 |
| Capek, R | 1 |
| De Koninck, Y | 1 |
| Fujikawa, DG | 1 |
| Itabashi, HH | 1 |
| Wu, A | 1 |
| Shinmei, SS | 1 |
| Yang, J | 1 |
| Sim, MK | 1 |
| Ling, EA | 1 |
38 other studies available for pilocarpine and Astrocytosis
| Article | Year |
|---|---|
Long-term ANT-DBS effects in pilocarpine-induced epileptic rats: A combined 9.4T MRI and histological study.
Topics: Adult; Animals; Deep Brain Stimulation; Epilepsy; Gliosis; Hippocampus; Humans; Magnetic Resonance I | 2023 |
A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Flufen | 2023 |
Pilocarpine-induced acute seizure causes rapid area-specific astrogliosis and alters purinergic signaling in rat hippocampus.
Topics: Animals; Astrocytes; Calcium; Epilepsy; Gliosis; Hippocampus; Pilocarpine; Rats; Seizures | 2023 |
Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model.
Topics: Adolescent; Adult; Animals; Anti-Inflammatory Agents; Convulsants; Cytokines; Encephalitis; Epilepsy | 2020 |
Daytime-restricted feeding modulates the expression of inflammatory mediators and diminishes reactive astrogliosis and microgliosis following status epilepticus.
Topics: Animals; Brain; Fasting; Gene Expression; Gliosis; Inflammation Mediators; Male; Microglia; Pilocarp | 2020 |
A Novel Second-Generation EP2 Receptor Antagonist Reduces Neuroinflammation and Gliosis After Status Epilepticus in Rats.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Gliosis; Humans; Inflammation Mediators; Male; | 2021 |
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
Topics: Animals; Astrocytes; Calcium Signaling; Disease Models, Animal; Disease Progression; Disease Suscept | 2021 |
Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model.
Topics: Animals; Astrocytes; Autoradiography; Brain; Carbazoles; Carrier Proteins; Disease Models, Animal; E | 2017 |
The differential roles of PEA15 phosphorylations in reactive astrogliosis and astroglial apoptosis following status epilepticus.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Astrocytes; Benzylamines; Fluorescent Antibody Te | 2018 |
Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cytokines; Dexamethasone; Dinoprostone; Disease Mode | 2018 |
The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2019 |
Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.
Topics: Animals; Dendrites; Dendritic Spines; Disease Models, Animal; Electroencephalography; Gliosis; Hippo | 2013 |
The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Neuro | 2013 |
Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus.
Topics: Amines; Animals; Astrocytes; Cyclohexanecarboxylic Acids; Electroencephalography; Gabapentin; gamma- | 2013 |
Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats.
Topics: Animals; Disease Models, Animal; Fenclonine; Gliosis; Hippocampus; Lithium; Magnetic Resonance Imagi | 2016 |
Postictal alterations induced by intrahippocampal injection of pilocarpine in C57BL/6 mice.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Male; Me | 2016 |
Antagonism of peripheral inflammation reduces the severity of status epilepticus.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Brain; Enz | 2009 |
Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus.
Topics: Animals; Antineoplastic Agents; Astrocytes; Cell Death; Cell Shape; Convulsants; Dentate Gyrus; Dise | 2009 |
ERK1/2 activation in reactive astrocytes of mice with pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; Cell Count; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Immunohistoc | 2009 |
Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats.
Topics: Animals; Anticonvulsants; Astrocytes; Chronic Disease; Epilepsy; Gliosis; Hippocampus; Interleukin-1 | 2010 |
Inflammation enhances epileptogenesis in the developing rat brain.
Topics: Age Factors; Aging; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy; Gliosis; Inflamma | 2010 |
Upregulation of Krüppel-like factor 6 in the mouse hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Gliosis; Hippocampus; Kruppel-Like Factor 6; Kruppel-Like Transcrip | 2011 |
Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model.
Topics: Animals; Anticonvulsants; Convulsants; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Poten | 2011 |
Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy.
Topics: Adolescent; Adult; Animals; Astrocytes; Child; Child, Preschool; Disease Models, Animal; Epilepsy; F | 2011 |
Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Cell Death; Disease Models, Animal; Disease Progression; Fluoresceins | 2012 |
Protective role of astrocytic leptin signaling against excitotoxicity.
Topics: Animals; Astrocytes; Astrocytoma; Cell Line, Tumor; Convulsants; Epilepsy; Female; Gene Expression R | 2013 |
Characterization of reactive astrocytes in the chronic phase of the pilocarpine model of epilepsy.
Topics: Animals; Astrocytes; Brain; Chronic Disease; Convulsants; Gliosis; Male; Pilocarpine; Rats; Rats, Wi | 2002 |
Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Behavior, Animal; Cell Death; Disease Models, Animal | 2003 |
Distribution of alpha and beta integrin subunits in the adult rat hippocampus after pilocarpine-induced neuronal cell loss, axonal reorganization and reactive astrogliosis.
Topics: Animals; Astrocytes; Axons; Cell Death; Gliosis; Hippocampus; Immunohistochemistry; Integrins; Male; | 2003 |
Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Behavior, Animal; Calcium-Binding Proteins; Dentate Gyrus; DNA-Binding Proteins; Electroenc | 2005 |
Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy.
Topics: Adenosine Triphosphatases; Animals; Astrocytes; Brain; Convulsants; Dentate Gyrus; Disease Models, A | 2006 |
Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat.
Topics: Animals; Anticonvulsants; Brain Damage, Chronic; Carbamazepine; Convulsants; Disease Models, Animal; | 2006 |
Analysis of the extracellular matrix protein SC1 during reactive gliosis in the rat lithium-pilocarpine seizure model.
Topics: Animals; Astrocytes; Brain; Calcium-Binding Proteins; Disease Models, Animal; Extracellular Matrix P | 2007 |
Pilocarpine-induced status epilepticus in rats involves ischemic and excitotoxic mechanisms.
Topics: Animals; Brain; Endothelium, Vascular; Gliosis; Image Processing, Computer-Assisted; Ischemia; Magne | 2007 |
Differential regulation of cytokine expression following pilocarpine-induced seizure.
Topics: Animals; Cell Death; Ciliary Neurotrophic Factor; Cytokines; Gene Expression Regulation; Gliosis; Gr | 1999 |
Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Behavior, Animal; Brain Mapping; Cell Count; Cell Death; Fluorescent Dyes; Gliosis; Hippoca | 2000 |
Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy.
Topics: Animals; Astrocytes; Brain; Cell Death; Electroencephalography; Entorhinal Cortex; Gliosis; Hippocam | 2000 |
Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Male; Muscarinic Agonist | 2001 |