pilocarpine has been researched along with Asthma in 23 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether increased release of acetylcholine may be involved in propranolol-induced bronchoconstriction (PIB), the inhibitory effect of pilocarpine (Pilo), an agonist of M2-muscarinic receptors that in 11 stable asthmatic subjects." | 7.69 | Effect of pilocarpine on propranolol-induced bronchoconstriction in asthma. ( Inoue, H; Lin, JT; Midorikawa, J; Okayama, M; Shen, T; Shirato, K; Takishima, T, 1994) |
| "RWJ 22108 (N-benzyl-N-methylaminoethyl 9-(2-chloro-6-fluorophenyl)-2,3,4,5,6,9-hexahydro-7-methyl-1, 1-dioxothiacyclohepteno-[3,2-b]pyridine-8-carboxylate) is a new bronchoselective calcium entry blocker with potential use as an antiasthmatic agent." | 7.68 | Experimental antiasthmatic activity of RWJ 22108: a bronchoselective calcium entry blocker. ( Ahmed, T; Anderson, DW; Capetola, RJ; Dodd, JH; Kirchner, T; Moore, JB; Ritchie, DM, 1993) |
| "To investigate whether increased release of acetylcholine may be involved in propranolol-induced bronchoconstriction (PIB), the inhibitory effect of pilocarpine (Pilo), an agonist of M2-muscarinic receptors that in 11 stable asthmatic subjects." | 3.69 | Effect of pilocarpine on propranolol-induced bronchoconstriction in asthma. ( Inoue, H; Lin, JT; Midorikawa, J; Okayama, M; Shen, T; Shirato, K; Takishima, T, 1994) |
| " In a second case report we describe, in a 61-year-old patient suffering from aspirin-sensitive asthma, recurrent ciliary body oedema with a marked spastic component which was triggered by the medications acetazolamide, dipivefrine and pilocarpine." | 3.69 | Drug-induced ciliary body oedema: a new theory. ( Krieg, PH; Schipper, I, 1996) |
| "RWJ 22108 (N-benzyl-N-methylaminoethyl 9-(2-chloro-6-fluorophenyl)-2,3,4,5,6,9-hexahydro-7-methyl-1, 1-dioxothiacyclohepteno-[3,2-b]pyridine-8-carboxylate) is a new bronchoselective calcium entry blocker with potential use as an antiasthmatic agent." | 3.68 | Experimental antiasthmatic activity of RWJ 22108: a bronchoselective calcium entry blocker. ( Ahmed, T; Anderson, DW; Capetola, RJ; Dodd, JH; Kirchner, T; Moore, JB; Ritchie, DM, 1993) |
| " We investigated whether these receptors may be involved in feedback inhibition of cholinergic reflex bronchoconstriction induced by sulfur dioxide (SO2) in seven nonasthmatic atopic subjects and in six mild asthmatic subjects." | 3.67 | A muscarinic agonist inhibits reflex bronchoconstriction in normal but not in asthmatic subjects. ( Barnes, PJ; Dixon, CM; Lammers, JW; McCusker, MT; Minette, PA, 1989) |
| " At about the same time that the Progestasert system was being developed, a membrane-based ocular system also was developed for the delivery of pilocarpine to treat glaucoma." | 3.67 | Membrane systems: practical applications. ( Smith, KL, 1985) |
| "Newly developing anisocoria may cause confusion and diagnostic difficulty in the emergency department (ED)." | 1.51 | Pharmacologic anisocoria due to nebulized ipratropium bromide: A diagnostic challenge. ( Akça, HŞ; Altunok, İ; Eroğlu, SE; Kokulu, K; Öner, H; Özen, C, 2019) |
| "Pilocarpine, which is an M2R stimulant, increased the density of M3R in the lung tissue and the rate of the increase in sensitized guinea pigs was less than that in the control group." | 1.31 | Role of muscarinic acetylcholine receptors in a guinea pig model of asthma. ( Fukuoka, M; Haraguchi, R; Itoh, M; Kubo, H; Nakajima, S; Ohkawa, K; Tohda, Y, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (52.17) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, MR | 1 |
| Dukan, E | 1 |
| Milne, I | 1 |
| Kokulu, K | 1 |
| Öner, H | 1 |
| Özen, C | 1 |
| Eroğlu, SE | 1 |
| Altunok, İ | 1 |
| Akça, HŞ | 1 |
| CURRY, JJ | 1 |
| LEARD, SE | 1 |
| Tohda, Y | 1 |
| Haraguchi, R | 1 |
| Itoh, M | 1 |
| Ohkawa, K | 1 |
| Kubo, H | 1 |
| Fukuoka, M | 1 |
| Nakajima, S | 1 |
| Hirota, N | 1 |
| Kamei, H | 1 |
| Hirano, M | 1 |
| Kawano, K | 1 |
| Murata, S | 1 |
| Imanishi, H | 1 |
| Kawaguchi, H | 1 |
| Van der Straeten, M | 1 |
| ten Berge, RE | 1 |
| Santing, RE | 1 |
| Hamstra, JJ | 1 |
| Roffel, AF | 1 |
| Zaagsma, J | 1 |
| Okayama, M | 1 |
| Shen, T | 1 |
| Midorikawa, J | 1 |
| Lin, JT | 1 |
| Inoue, H | 1 |
| Takishima, T | 1 |
| Shirato, K | 1 |
| Ritchie, DM | 1 |
| Kirchner, T | 1 |
| Moore, JB | 1 |
| Dodd, JH | 1 |
| Ahmed, T | 1 |
| Anderson, DW | 1 |
| Capetola, RJ | 1 |
| Krieg, PH | 1 |
| Schipper, I | 1 |
| Song, P | 1 |
| Milanese, M | 1 |
| Crimi, E | 1 |
| Rehder, K | 1 |
| Brusasco, V | 1 |
| Schulman, SR | 1 |
| Canada, AT | 1 |
| Fryer, AD | 2 |
| Winsett, DW | 1 |
| Costa, DL | 1 |
| Costello, RW | 1 |
| Schofield, BH | 1 |
| Kephart, GM | 1 |
| Gleich, GJ | 1 |
| Jacoby, DB | 1 |
| Wang, SZ | 1 |
| Minette, PA | 1 |
| Lammers, JW | 1 |
| Dixon, CM | 1 |
| McCusker, MT | 1 |
| Barnes, PJ | 1 |
| Böhm, E | 1 |
| Fabel, H | 1 |
| Jannun, DR | 1 |
| Mickel, SF | 1 |
| Smith, KL | 1 |
| Takino, M | 1 |
| Bruchhausen, D | 3 |
| Haschem, J | 3 |
| Baack, G | 1 |
| Ricken, D | 1 |
| Dardenne, MU | 2 |
2 trials available for pilocarpine and Asthma
| Article | Year |
|---|---|
[A study on the functional condition of airway muscarinic M2-receptors in asthma].
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Fema | 1992 |
[Changes in lung function following administration of eyedrops containing timolol, metipranolol, pindolol and pilocarpine in healthy probands and patients with mild bronchial asthma].
Topics: Airway Resistance; Asthma; Bronchial Spasm; Clinical Trials as Topic; Double-Blind Method; Humans; L | 1987 |
21 other studies available for pilocarpine and Asthma
| Article | Year |
|---|---|
Amanita muscaria (fly agaric): from a shamanistic hallucinogen to the search for acetylcholine.
Topics: Acetylcholine; Amanita; Asthma; Cholinergic Antagonists; History, 16th Century; History, 17th Centur | 2018 |
Pharmacologic anisocoria due to nebulized ipratropium bromide: A diagnostic challenge.
Topics: Adult; Aerosols; Anisocoria; Asthma; Bronchodilator Agents; Female; Humans; Ipratropium; Pilocarpine | 2019 |
The action of pilocarpine on the lungs in normal and asthmatic subjects.
Topics: Asthma; Pilocarpine; Tripelennamine | 1948 |
Role of muscarinic acetylcholine receptors in a guinea pig model of asthma.
Topics: Animals; Asthma; Diamines; Gallamine Triethiodide; Guinea Pigs; Membranes; Muscarinic Agonists; Nico | 2002 |
[Studies on urinary catecholamines and their metabolites in bronchial asthma].
Topics: Adolescent; Adult; Aged; Animals; Asthma; Betamethasone; Catecholamines; Epinephrine; Female; Humans | 1966 |
Pharmacological studies on BB-1502, a new bronchodilator.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetylcholine; Adenine; Aminophylline; Animals; Asthma; Broncho | 1981 |
Bronchial hyperreactivity. Ghent, 8 November 1980. Introduction.
Topics: Asthma; Bronchi; Histamine; History, 20th Century; Humans; Male; Pilocarpine; Respiratory Hypersensi | 1982 |
Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Benzodiazepinones; Bronchial Hyperreactivity | 1995 |
Effect of pilocarpine on propranolol-induced bronchoconstriction in asthma.
Topics: Acetylcholine; Adolescent; Adult; Airway Resistance; Asthma; Atropine; Bronchial Provocation Tests; | 1994 |
Experimental antiasthmatic activity of RWJ 22108: a bronchoselective calcium entry blocker.
Topics: Airway Obstruction; Airway Resistance; Animals; Antigens; Asthma; Bronchial Spasm; Bronchoconstricti | 1993 |
Drug-induced ciliary body oedema: a new theory.
Topics: Acetazolamide; Adult; Asthma; Chlorthalidone; Ciliary Body; Diuretics; Edema; Epinephrine; Female; H | 1996 |
Allergen challenge of passively sensitized human bronchi alters M2 and beta2 receptor function.
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Allergens; Animals; Asthma; Bronchi; Bronchial Hyp | 1997 |
Airway hyperreactivity produced by short-term exposure to hyperoxia in neonatal guinea pigs.
Topics: Acetylcholine; Acetylcholinesterase; Airway Resistance; Animals; Animals, Newborn; Asthma; Bronchial | 1997 |
Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function.
Topics: Acetylcholinesterase; Adult; Animals; Antigens; Asthma; Eosinophils; Female; Guinea Pigs; Humans; Hy | 1997 |
A muscarinic agonist inhibits reflex bronchoconstriction in normal but not in asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Female; Histamine; Humans; Male; Pilocarpine; Receptors, | 1989 |
Anisocoria and aerosolized anticholinergics.
Topics: Acute Disease; Adolescent; Adult; Aerosols; Aged; Asthma; Female; Humans; Male; Middle Aged; Parasym | 1986 |
Membrane systems: practical applications.
Topics: Administration, Topical; Asthma; Bronchitis; Delayed-Action Preparations; Drug Implants; Estriol; Fe | 1985 |
The role of the autonomic nervous system in the pathogenesis of allergy, with special reference of organ vagotonia.
Topics: Acetylcholine; Antibody Formation; Asthma; Bradykinin; Bronchi; Carotid Sinus; Histamine; Hypersensi | 1973 |
[Drug-induced bronchospasms in asthmatic patients].
Topics: Asthma; Bronchial Spasm; Humans; Pilocarpine | 1971 |
Effect of intraconjunctival application of pilocarpine on bronchial resistance in asthmatics.
Topics: Asthma; Bronchi; Conjunctiva; Constriction; Glaucoma; Humans; Injections; Ophthalmic Solutions; Para | 1969 |
[Changes in the brinchial resistance in asthmatics following application of pilocarpine in the conjunctival sac].
Topics: Acetazolamide; Asthma; Bronchial Spasm; Conjunctiva; Dosage Forms; Glaucoma; Humans; Medical History | 1969 |