pilocarpine has been researched along with Alzheimer Disease in 15 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, tau expression and phosphorylation at three canonical loci known to be hyperphosphorylated in AD (S202/T205, T181, and T231) were studied in the rat pilocarpine status epilepticus (SE) model of temporal lobe epilepsy (TLE)." | 4.31 | Progressive Dysregulation of Tau Phosphorylation in an Animal Model of Temporal Lobe Epilepsy. ( Concepcion, FA; Ekstrom, NA; Estes, OO; Khan, MN; Poolos, NP, 2023) |
| "The comorbidity between epilepsy and Alzheimer's disease (AD) is a topic of growing interest." | 1.38 | Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice. ( Cai, H; Cai, Y; Deng, SH; Laferla, FM; Luo, XG; Oddo, S; Patrylo, PR; Rose, GM; Shelton, J; Yan, XX, 2012) |
| "Alzheimer disease, Pick disease and senile dementia are all characterized by similar morphological changes, both macroscopic and microscopic, and similar psychiatric symptoms." | 1.29 | The diseases of Alzheimer and Pick from the viewpoint of prevention. ( Marcinkowski, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Concepcion, FA | 1 |
| Ekstrom, NA | 1 |
| Khan, MN | 1 |
| Estes, OO | 1 |
| Poolos, NP | 1 |
| Chen, YY | 1 |
| Lai, YJ | 1 |
| Yen, YF | 1 |
| Shen, YC | 1 |
| Wang, CY | 1 |
| Liang, CY | 1 |
| Lin, KH | 1 |
| Fan, LW | 1 |
| Yan, XX | 1 |
| Cai, Y | 1 |
| Shelton, J | 1 |
| Deng, SH | 1 |
| Luo, XG | 1 |
| Oddo, S | 1 |
| Laferla, FM | 1 |
| Cai, H | 1 |
| Rose, GM | 1 |
| Patrylo, PR | 1 |
| Hanyu, H | 1 |
| Hirao, K | 1 |
| Shimizu, S | 1 |
| Kanetaka, H | 1 |
| Sakurai, H | 1 |
| Iwamoto, T | 1 |
| Pion, B | 1 |
| Salu, P | 1 |
| Pomara, N | 2 |
| Stanley, M | 1 |
| Idiaquez, J | 1 |
| Alvarez, G | 1 |
| Villagra, R | 1 |
| San Martin, RA | 1 |
| Katz, B | 1 |
| Sitaram, N | 1 |
| Marcinkowski, T | 1 |
| Kaneyuki, H | 1 |
| Mitsuno, S | 1 |
| Nishida, T | 1 |
| Yamada, M | 1 |
| Wozniak, DF | 1 |
| Dikranian, K | 1 |
| Ishimaru, MJ | 1 |
| Nardi, A | 1 |
| Corso, TD | 1 |
| Tenkova, T | 1 |
| Olney, JW | 1 |
| Fix, AS | 1 |
| Bymaster, FP | 1 |
| Carter, PA | 1 |
| DeLapp, NW | 1 |
| Calligaro, DO | 1 |
| Felder, CC | 1 |
| Fisher, A | 1 |
| Brandeis, R | 1 |
| Karton, I | 1 |
| Pittel, Z | 1 |
| Gurwitz, D | 1 |
| Haring, R | 1 |
| Sapir, M | 1 |
| Levy, A | 1 |
| Heldman, E | 1 |
| Reyes, PF | 1 |
| Dwyer, BA | 1 |
| Schwartzman, RJ | 1 |
| Sacchetti, T | 1 |
1 review available for pilocarpine and Alzheimer Disease
| Article | Year |
|---|---|
Herpes zoster ophthalmicus complicated by complete ophthalmoplegia and signs of pilocarpine hypersensitivity. A case report and literature review.
Topics: Acyclovir; Aged; Alzheimer Disease; Benzimidazoles; Drug Hypersensitivity; Drug Therapy, Combination | 2007 |
1 trial available for pilocarpine and Alzheimer Disease
| Article | Year |
|---|---|
Cholinergic supersensitivity of the iris in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Humans; Iris; Male; Middle Aged; Pilocarpine; Pu | 1994 |
13 other studies available for pilocarpine and Alzheimer Disease
| Article | Year |
|---|---|
Progressive Dysregulation of Tau Phosphorylation in an Animal Model of Temporal Lobe Epilepsy.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Mo | 2023 |
Association between normal tension glaucoma and the risk of Alzheimer's disease: a nationwide population-based cohort study in Taiwan.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Age Factors; Aged; Alzheimer Disease; Carbon | 2018 |
Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; As | 2012 |
Phenylephrine and pilocarpine eye drop test for dementia with Lewy bodies and Alzheimer's disease.
Topics: 3-Iodobenzylguanidine; Aged; Aged, 80 and over; Alzheimer Disease; Diagnosis, Differential; Female; | 2007 |
Cholinergic precursors in Alzheimer's disease.
Topics: Alzheimer Disease; Choline; Dementia; Humans; Pilocarpine; Receptors, Muscarinic | 1982 |
Detecting Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Pilocarpine; Pupil; Receptors, Cholinergic; Up-Regulation | 1995 |
Detecting Alzheimer's disease.
Topics: Alzheimer Disease; Eye Color; Humans; Pilocarpine; Pupil | 1995 |
The diseases of Alzheimer and Pick from the viewpoint of prevention.
Topics: Aged; Alzheimer Disease; Antigens; Dementia; Humans; Immune Complex Diseases; Parasympathomimetics; | 1996 |
Enhanced miotic response to topical dilute pilocarpine in patients with Alzheimer's disease.
Topics: Administration, Topical; Aged; Alzheimer Disease; Female; Humans; Male; Miotics; Mydriatics; Pilocar | 1998 |
Disseminated corticolimbic neuronal degeneration induced in rat brain by MK-801: potential relevance to Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Dizocilpine Maleate; Drug Combinations; Excitatory Amin | 1998 |
Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cholinergic Fibers; Dioxolanes; Dose-Response Relationshi | 2001 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Binding, Competitive; Cognition Disorders; Copper; D | 1991 |
Mental status changes induced by eye drops in dementia of the Alzheimer type.
Topics: Aged; Alzheimer Disease; Cognition; Female; Humans; Male; Ophthalmic Solutions; Pilocarpine | 1987 |