pilocarpine has been researched along with Aging in 77 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine if there is a window of vulnerability in the developing rat, post-natal day 19 animals were subjected to a severe lateral fluid percussion injury followed by pilocarpine (Pc)-induced status epilepticus at 1, 6 or 24 h post TBI." | 7.75 | Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. ( Auvin, S; Giza, CC; Gurkoff, GG; Hovda, DA; Sankar, R; Shin, D, 2009) |
| "The effects of repetitive pilocarpine-induced status epilepticus (SE) in the hippocampal Na(+)/K(+)ATPase activity were studied in developing rat." | 7.74 | The Na+/K+ATPase activity is increased in the hippocampus after multiple status epilepticus induced by pilocarpine in developing rats. ( Arida, RM; da Silva Fernandes, MJ; Mara de Oliveira, D; Reime Kinjo, E, 2007) |
| "Distribution of LiCl/pilocarpine status epilepticus-induced neuronal damage was studied in the piriform cortex and in adjoining structures in 12-day-old, 25-day-old and adult rats." | 7.72 | Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent. ( Druga, R; Haugvicová, R; Kubová, H; Suchomelová, L, 2003) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 7.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| "Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain." | 7.71 | Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats. ( Cheng, SC; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, TJ; Wu, CL; Yang, SN, 2002) |
| " This study investigated p53 expression in the immature and adult rat brain following status epilepticus induced by the administration of lithium-pilocarpine (LPSE)." | 7.71 | Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus. ( Liu, H; Sankar, R; Schreiber, SS; Shin, D; Sun, N; Tan, Z; Wasterlain, CG, 2002) |
| " Lithium-pilocarpine-induced status epilepticus is associated with extended damage in adult rats, mostly in the forebrain limbic areas and thalamus, whereas damage was moderate in 21-day-old rats (P21) or absent in P10 rats." | 7.71 | Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage. ( Ferrandon, A; Nehlig, A; Pereira de Vasconcelos, A, 2002) |
| "Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE)." | 7.71 | Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss. ( Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL, 2001) |
| "The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE)." | 7.70 | Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats. ( Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A, 1999) |
| " However, unlike monkeys, humans exhibit no loss of the intraocular pressure or outflow facility response to pilocarpine with age." | 7.69 | Aging effects on accommodation and outflow facility responses to pilocarpine in humans. ( Croft, MA; Fisher, MR; Gange, SJ; Kaufman, PL; Oyen, MJ, 1996) |
| "Lithium is known to potentiate the ability of pilocarpine to induce status epilepticus in rats." | 7.68 | Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats. ( Baram, TZ; Hirsch, E; Snead, OC, 1992) |
| "Additionally, once status epilepticus is observed at any age, there is a corresponding SE-induced inhibition of CaM kinase II." | 5.33 | Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat. ( Churn, SB; Holbert, WH; Kurz, JE; Lee, AT; Ryan, ML; Singleton, MW, 2005) |
| "Propranolol was given in high (20 mg/kg/day) and low (10 mg/kg/day) doses via osmotic pumps." | 5.29 | The effect of propranolol on salivary gland function and dental caries development in young and aged rats. ( Bowen, WH; O'Connell, AC; Pearson, SK; Van Wuyckhuyse, BC, 1993) |
| "No overt motor seizures were observed in this age group." | 5.27 | The susceptibility of rats to pilocarpine-induced seizures is age-dependent. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Silva, DF; Turski, L; Turski, WA, 1987) |
| "The present study examined whether status epilepticus (SE) induced by LiCl-pilocarpine in immature rats (postnatal day [P]12) interferes with normal development; leads to progressive epileptogenesis, or cognitive decline and to pathology similar to that seen in human temporal lobe epilepsy." | 3.79 | Are morphologic and functional consequences of status epilepticus in infant rats progressive? ( Kubová, H; Mareš, P, 2013) |
| " Inflammation, angiogenesis and BBB permeability were studied in postnatal day (PN)9 and PN21 rats, 1 week and 4 months after pilocarpine-induced status epilepticus." | 3.75 | Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis. ( Balosso, S; Gagliardi, B; Lerner-Natoli, M; Marcon, J; Maroso, M; Morin, M; Noé, F; Ravizza, T; Vezzani, A, 2009) |
| " To determine if there is a window of vulnerability in the developing rat, post-natal day 19 animals were subjected to a severe lateral fluid percussion injury followed by pilocarpine (Pc)-induced status epilepticus at 1, 6 or 24 h post TBI." | 3.75 | Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. ( Auvin, S; Giza, CC; Gurkoff, GG; Hovda, DA; Sankar, R; Shin, D, 2009) |
| "The effects of repetitive pilocarpine-induced status epilepticus (SE) in the hippocampal Na(+)/K(+)ATPase activity were studied in developing rat." | 3.74 | The Na+/K+ATPase activity is increased in the hippocampus after multiple status epilepticus induced by pilocarpine in developing rats. ( Arida, RM; da Silva Fernandes, MJ; Mara de Oliveira, D; Reime Kinjo, E, 2007) |
| "Distribution of LiCl/pilocarpine status epilepticus-induced neuronal damage was studied in the piriform cortex and in adjoining structures in 12-day-old, 25-day-old and adult rats." | 3.72 | Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent. ( Druga, R; Haugvicová, R; Kubová, H; Suchomelová, L, 2003) |
| "Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain." | 3.71 | Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats. ( Cheng, SC; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, TJ; Wu, CL; Yang, SN, 2002) |
| "Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE)." | 3.71 | Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss. ( Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL, 2001) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 3.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| " Lithium-pilocarpine-induced status epilepticus is associated with extended damage in adult rats, mostly in the forebrain limbic areas and thalamus, whereas damage was moderate in 21-day-old rats (P21) or absent in P10 rats." | 3.71 | Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage. ( Ferrandon, A; Nehlig, A; Pereira de Vasconcelos, A, 2002) |
| " This study investigated p53 expression in the immature and adult rat brain following status epilepticus induced by the administration of lithium-pilocarpine (LPSE)." | 3.71 | Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus. ( Liu, H; Sankar, R; Schreiber, SS; Shin, D; Sun, N; Tan, Z; Wasterlain, CG, 2002) |
| "The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE)." | 3.70 | Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats. ( Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A, 1999) |
| " However, unlike monkeys, humans exhibit no loss of the intraocular pressure or outflow facility response to pilocarpine with age." | 3.69 | Aging effects on accommodation and outflow facility responses to pilocarpine in humans. ( Croft, MA; Fisher, MR; Gange, SJ; Kaufman, PL; Oyen, MJ, 1996) |
| " Significant elevations of extracellular glutamate were observed following seizures induced by either kainic acid or pilocarpine." | 3.69 | Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study. ( Holmes, GL; Hori, A; Liu, Z; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y, 1997) |
| "Lithium is known to potentiate the ability of pilocarpine to induce status epilepticus in rats." | 3.68 | Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats. ( Baram, TZ; Hirsch, E; Snead, OC, 1992) |
| "Focal sweating in the dorsum of foot induced by iontophoresis of 1% pilocarpine was quantitatively evaluated using silastic impression mold technique in 111 control subjects (71 men & 40 women), aged 14 to 89 years, to reveal the effect of aging on the density of active sweat glands." | 3.68 | [The effect of ageing on the active sweat gland density in the dorsum of foot]. ( Ikeda, M; Muta, Y; Ohnishi, A; Yamamoto, T, 1991) |
| "In aging eyes phenylephrine drops have no significant effect on the depth of the anterior chamber, whereas pilocarpine drops produce a significant shallowing." | 3.66 | Acute shallowing of the anterior chamber. ( Mapstone, R, 1981) |
| "Pilocarpine treatment reduced immobility time in forced swimming test but did not affect fear conditioning response, sucrose preference or novelty supressed feeding behaviour." | 1.51 | Enduring effects of muscarinic receptor activation on adult hippocampal neurogenesis, microRNA expression and behaviour. ( Cryan, JF; Dinan, TG; Gururajan, A; Hoeller, AA; Levone, BR; Lino-de-Oliveira, C; Moloney, G; Monteiro de Lima, TC; O'Leary, OF; Ramos Costa, AP, 2019) |
| "Transition into limbic seizures and recurrent seizures were delayed in both age groups and threshold intensities for limbic ADs were at some intervals higher in SE than in control animals." | 1.35 | Changes of cortical epileptic afterdischarges after status epilepticus in immature rats. ( Kubová, H; Mares, P; Tsenov, G, 2008) |
| "Additionally, once status epilepticus is observed at any age, there is a corresponding SE-induced inhibition of CaM kinase II." | 1.33 | Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat. ( Churn, SB; Holbert, WH; Kurz, JE; Lee, AT; Ryan, ML; Singleton, MW, 2005) |
| "Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior." | 1.33 | Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. ( Holmes, GL; Liu, Z; Mikati, M; Neill, JC, 2005) |
| "The treatment with pilocarpine improved in a specific manner these age-related deficits in 24 month-old rats without altering their motor performance." | 1.33 | Pilocarpine improves olfactory discrimination and social recognition memory deficits in 24 month-old rats. ( De-Mello, N; Prediger, RD; Takahashi, RN, 2006) |
| "Propranolol was given in high (20 mg/kg/day) and low (10 mg/kg/day) doses via osmotic pumps." | 1.29 | The effect of propranolol on salivary gland function and dental caries development in young and aged rats. ( Bowen, WH; O'Connell, AC; Pearson, SK; Van Wuyckhuyse, BC, 1993) |
| "Inositol-4-phosphate was stable in the young rats but increased in the frontal cortex and the hippocampus in the old rats." | 1.29 | Sustained effects of pilocarpine-induced convulsions on brain inositol and inositol monophosphate levels and brain morphology in young and old male rats. ( Hirvonen, MR; Paljärvi, L; Savolainen, KM, 1993) |
| "Isoproterenol (IPR) was given to mice 27 and 29 months old to assess whether levels of mucin could be restored to levels similar to those in younger mice." | 1.28 | Increased mucin levels in submandibular glands of aged male mice after chronic isoproterenol treatment. ( Denny, PA; Denny, PC; Klauser, DK; Villa, BJ, 1991) |
| "Drug induced xerostomia is not uncommon particularly among the aging." | 1.28 | Drug-induced xerostomia. ( Butt, GM, 1991) |
| "No overt motor seizures were observed in this age group." | 1.27 | The susceptibility of rats to pilocarpine-induced seizures is age-dependent. ( Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Silva, DF; Turski, L; Turski, WA, 1987) |
| "Spiperone produced catalepsy in rats 1, 5 and 10 days old, and also in adults." | 1.26 | Postnatal development of dopaminergic and cholinergic catalepsy in the rat. ( Baez, LA; Eskridge, NK; Schein, R, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (32.47) | 18.7374 |
| 1990's | 26 (33.77) | 18.2507 |
| 2000's | 20 (25.97) | 29.6817 |
| 2010's | 5 (6.49) | 24.3611 |
| 2020's | 1 (1.30) | 2.80 |
| Authors | Studies |
|---|---|
| Mátyás, A | 1 |
| Borbély, E | 1 |
| Mihály, A | 1 |
| Ramos Costa, AP | 1 |
| Levone, BR | 1 |
| Gururajan, A | 1 |
| Moloney, G | 1 |
| Hoeller, AA | 1 |
| Lino-de-Oliveira, C | 1 |
| Dinan, TG | 1 |
| O'Leary, OF | 1 |
| Monteiro de Lima, TC | 1 |
| Cryan, JF | 1 |
| Marcon, J | 1 |
| Gagliardi, B | 1 |
| Balosso, S | 1 |
| Maroso, M | 1 |
| Noé, F | 1 |
| Morin, M | 1 |
| Lerner-Natoli, M | 1 |
| Vezzani, A | 1 |
| Ravizza, T | 1 |
| Gurkoff, GG | 1 |
| Giza, CC | 1 |
| Shin, D | 4 |
| Auvin, S | 2 |
| Sankar, R | 4 |
| Hovda, DA | 1 |
| Sprenger, N | 1 |
| Julita, M | 1 |
| Donnicola, D | 1 |
| Jann, A | 1 |
| Lopez-Meraz, ML | 1 |
| Wasterlain, CG | 2 |
| Rocha, LL | 1 |
| Allen, S | 1 |
| Niquet, J | 1 |
| Mazarati, A | 2 |
| Leroy, C | 1 |
| Pierre, K | 1 |
| Simpson, IA | 1 |
| Pellerin, L | 1 |
| Vannucci, SJ | 1 |
| Nehlig, A | 4 |
| Kubová, H | 3 |
| Mareš, P | 2 |
| Liu, H | 2 |
| Wasterlain, C | 1 |
| Dubé, C | 2 |
| Koning, E | 1 |
| Druga, R | 1 |
| Suchomelová, L | 1 |
| Haugvicová, R | 1 |
| Setkowicz, Z | 1 |
| Janeczko, K | 1 |
| ARMALY, MF | 2 |
| LIEBERMAN, J | 1 |
| KELLOGG, F | 1 |
| PRUITT, A | 1 |
| HALASA, AH | 1 |
| TAMMISTO, T | 1 |
| CASTREN, JA | 1 |
| MARTTILA, I | 1 |
| HUNTER, RL | 1 |
| ROCHA, JT | 1 |
| PFRENDER, AR | 1 |
| DEJONG, DC | 1 |
| De-Mello, N | 2 |
| Souza-Junior, IQ | 1 |
| Carobrez, AP | 1 |
| Singleton, MW | 1 |
| Holbert, WH | 1 |
| Ryan, ML | 1 |
| Lee, AT | 1 |
| Kurz, JE | 1 |
| Churn, SB | 1 |
| Prediger, RD | 1 |
| Takahashi, RN | 1 |
| Neill, JC | 1 |
| Liu, Z | 2 |
| Mikati, M | 1 |
| Holmes, GL | 2 |
| Reime Kinjo, E | 1 |
| Arida, RM | 1 |
| Mara de Oliveira, D | 1 |
| da Silva Fernandes, MJ | 1 |
| Tsenov, G | 1 |
| Wendt, M | 1 |
| Croft, MA | 3 |
| McDonald, J | 1 |
| Kaufman, PL | 5 |
| Glasser, A | 1 |
| Lobeck, CC | 1 |
| McSherry, NR | 1 |
| Bodner, L | 2 |
| Baum, BJ | 2 |
| Webster, HL | 1 |
| Mapstone, R | 1 |
| Hitchings, RA | 1 |
| Powell, DJ | 1 |
| Hirvonen, MR | 1 |
| Paljärvi, L | 1 |
| Savolainen, KM | 1 |
| O'Connell, AC | 2 |
| Van Wuyckhuyse, BC | 1 |
| Pearson, SK | 1 |
| Bowen, WH | 2 |
| da Penha Berzaghi, M | 1 |
| Cooper, J | 1 |
| Castrén, E | 1 |
| Zafra, F | 1 |
| Sofroniew, M | 1 |
| Thoenen, H | 1 |
| Lindholm, D | 1 |
| Hartmann, H | 1 |
| Cohen, SA | 1 |
| Müller, WE | 1 |
| Oyen, MJ | 1 |
| Gange, SJ | 1 |
| Fisher, MR | 1 |
| Stafstrom, CE | 1 |
| Sarkisian, MR | 1 |
| Yang, Y | 1 |
| Hori, A | 1 |
| Tandon, P | 1 |
| Fox, PC | 1 |
| Fernandes, MJ | 1 |
| Boyet, S | 1 |
| Marescaux, C | 1 |
| Pardue, MT | 1 |
| Sivak, JG | 1 |
| Wu, CL | 2 |
| Huang, LT | 2 |
| Liou, CW | 2 |
| Wang, TJ | 2 |
| Tung, YR | 1 |
| Hsu, HY | 1 |
| Lai, MC | 2 |
| Pereira de Vasconcelos, A | 1 |
| Ferrandon, A | 1 |
| Tan, Z | 1 |
| Sun, N | 1 |
| Schreiber, SS | 1 |
| Vilches, JJ | 1 |
| Ceballos, D | 1 |
| Verdú, E | 1 |
| Navarro, X | 4 |
| Yang, SN | 1 |
| Hung, PL | 1 |
| Cheng, SC | 1 |
| Baez, LA | 1 |
| Eskridge, NK | 1 |
| Schein, R | 1 |
| Hirsch, E | 1 |
| Baram, TZ | 1 |
| Snead, OC | 1 |
| Rajakumar, G | 1 |
| Koller, MM | 2 |
| Scarpace, PJ | 2 |
| Maeda, N | 1 |
| Purushotham, KR | 1 |
| Humphreys-Beher, MG | 1 |
| Tamm, E | 2 |
| Jungkunz, W | 1 |
| Lütjen-Drecoll, E | 2 |
| Riekkinen, P | 8 |
| Riekkinen, M | 2 |
| Jäkälä, P | 2 |
| Sirvioö, J | 1 |
| Lammintausta, R | 2 |
| Sirviö, J | 2 |
| Denny, PC | 1 |
| Denny, PA | 1 |
| Villa, BJ | 1 |
| Klauser, DK | 1 |
| Melvin, JE | 1 |
| Koek, L | 1 |
| Muta, Y | 1 |
| Ohnishi, A | 1 |
| Yamamoto, T | 1 |
| Ikeda, M | 1 |
| Drummond, PD | 1 |
| Aaltonen, M | 1 |
| Gabelt, BT | 1 |
| Crawford, K | 1 |
| Butt, GM | 1 |
| Ishikawa, S | 1 |
| Panzeri, G | 1 |
| Torsello, A | 1 |
| Cella, SG | 1 |
| Müller, EE | 1 |
| Locatelli, V | 1 |
| Kennedy, WR | 3 |
| Sugiyama, T | 1 |
| Utsumi, T | 1 |
| Miyashita, Y | 1 |
| Moriya, S | 1 |
| Suzuki, M | 1 |
| Maetani, S | 1 |
| Senda, S | 1 |
| Cheng, E | 1 |
| Kawanishi, H | 1 |
| Steuhl, KP | 1 |
| Ordway, GA | 1 |
| Esbenshade, TA | 1 |
| Kolta, MG | 1 |
| Gerald, MC | 1 |
| Wallace, LJ | 1 |
| Inanaga, A | 1 |
| Habu, T | 1 |
| Tanaka, E | 1 |
| Taniguchi, T | 1 |
| Nishiura, T | 1 |
| Ishibashi, K | 1 |
| Naruse, S | 1 |
| Abe, K | 1 |
| Kishimoto, O | 1 |
| Kamei, H | 1 |
| Cavalheiro, EA | 1 |
| Silva, DF | 1 |
| Turski, WA | 1 |
| Calderazzo-Filho, LS | 1 |
| Bortolotto, ZA | 1 |
| Turski, L | 1 |
| Igata, A | 1 |
| Marley, E | 1 |
| Seller, TJ | 1 |
| Yamamoto, Y | 1 |
| Suzumura, A | 1 |
| Taniguchi, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Inhaled Corticosteroids on Intraocular Pressure in Patients With Ocular Hypertension or Controlled Glaucoma.[NCT02338362] | Phase 4 | 22 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| An Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray on the Relief of Dry Mouth Symptoms[NCT04186806] | 40 participants (Actual) | Interventional | 2019-11-02 | Completed | |||
| Multicenter, Controlled Parallel Groups Trial to Evaluate the Efficacy, Safety and Acceptability of OGT Oromucosal Spray Versus a Saliva Substitute in the Treatment of Xerostomia in Geriatrics[NCT00350350] | 74 participants (Actual) | Observational | 2003-10-31 | Completed | |||
| Multicenter Controlled Parallel-Groups Trial to Evaluate the Efficacy, Safety and Acceptability of TGO Buccal Spray Versus a Saliva Substitute in the Treatment of Psychotropic Medicines-Induced Xerostomia[NCT00332618] | 74 participants | Observational | 2003-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Adherence was calculated from self-reported study diaries and correlated to a counter that measured number of inhaled puffs built into the placebo metered-dose inhalers (NCT02338362)
Timeframe: Completion of study, up to 6 weeks
| Intervention | percentage of required doses (Mean) |
|---|---|
| Fluticasone | 93.6 |
| Saline Placebo | 96.1 |
Masked assessment of intraocular pressure using goldmann application tonometry. Mean of 2 measurements within 1 mmHg will be recorded. (NCT02338362)
Timeframe: week 6
| Intervention | mmHg (Mean) |
|---|---|
| Fluticasone | 14.7 |
| Saline Placebo | 14.8 |
best corrected logMAR visual acuity for each eye. 20/20 vision corresponds with a logMAR score of 0, while negative logMAR scores indicate better than 20/20 vision, values > 0.5 correspond with low vision, and values > 1.3 correspond with blindness. (NCT02338362)
Timeframe: week 6
| Intervention | logMAR (Mean) |
|---|---|
| Fluticasone | 0.15 |
| Saline Placebo | 0.15 |
Participants with 2 consecutive intraocular pressure measurements exceeding 20% increase from baseline were discontinued from study. (NCT02338362)
Timeframe: within 6-week observation period
| Intervention | participants (Number) | |
|---|---|---|
| elevation >20% | no elevation >20% | |
| Fluticasone | 1 | 9 |
| Saline Placebo | 0 | 10 |
subjective (reported) and objective (slit lamp examination) side-effects attributable to study medications (NCT02338362)
Timeframe: from baseline to week 6
| Intervention | participants (Number) | ||||
|---|---|---|---|---|---|
| lens opacity | throat discomfort | headache | difficulty sleeping | no adverse effects | |
| Fluticasone | 0 | 1 | 1 | 0 | 8 |
| Saline Placebo | 0 | 1 | 0 | 1 | 8 |
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 120 minutes
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 4.86 |
| Biotene Moisturizing Mouth Spray | 5.41 |
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 30 minutes
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 4.51 |
| Biotene Moisturizing Mouth Spray | 4.75 |
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 60 minutes
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 4.58 |
| Biotene Moisturizing Mouth Spray | 5.04 |
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 240 minutes post dose
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 5.14 |
| Biotene Moisturizing Mouth Spray | 5.68 |
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms (NCT04186806)
Timeframe: 5 minutes
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 4.54 |
| Biotene Moisturizing Mouth Spray | 4.62 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 15 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | -2.394 |
| Biotene Moisturizing Mouth Spray | -2.036 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 30 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | -2.420 |
| Biotene Moisturizing Mouth Spray | -1.900 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 5 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | -2.203 |
| Biotene Moisturizing Mouth Spray | -1.871 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 120 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | -2.364 |
| Biotene Moisturizing Mouth Spray | -1.657 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 240 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M Dry Mouth Moisturizing Spray | -2.322 |
| Biotene Moisturizing Mouth Spray | -1.665 |
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water. (NCT04186806)
Timeframe: 60 minutes
| Intervention | cm (Least Squares Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | -2.455 |
| Biotene Moisturizing Mouth Spray | -1.833 |
Primary endpoint will be paired-difference in Visual Analog Scale (VAS) between experimental and active control product. On the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms. (NCT04186806)
Timeframe: 15 minutes post dose
| Intervention | cm (Mean) |
|---|---|
| 3M(TM) Dry Mouth Moisturizing Spray | 4.51 |
| Biotene Moisturizing Mouth Spray | 4.6 |
3 reviews available for pilocarpine and Aging
| Article | Year |
|---|---|
Laboratory diagnosis of cystic fibrosis.
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Chlorides; Cystic Fibrosis; Disease; Electric Con | 1983 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Management of dry mouth.
Topics: Aged; Aging; Drug-Related Side Effects and Adverse Reactions; Humans; Mouth; Mouth Diseases; Parasym | 1997 |
Ultrastructure of the conjunctival epithelium.
Topics: Absorption; Aging; Animals; Conjunctiva; Cornea; Epithelium; Eye Diseases; Histocytochemistry; Human | 1989 |
74 other studies available for pilocarpine and Aging
| Article | Year |
|---|---|
Hippocampal Sclerosis in Pilocarpine Epilepsy: Survival of Peptide-Containing Neurons and Learning and Memory Disturbances in the Adult NMRI Strain Mouse.
Topics: Aging; Animals; Calbindin 2; Cell Proliferation; Cell Survival; Densitometry; Epilepsy; Hippocampus; | 2021 |
Enduring effects of muscarinic receptor activation on adult hippocampal neurogenesis, microRNA expression and behaviour.
Topics: Aging; Animals; Behavior, Animal; Hippocampus; Male; MicroRNAs; Neurogenesis; Neurons; Pilocarpine; | 2019 |
Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis.
Topics: Aging; Animals; Astrocytes; Blood-Brain Barrier; Encephalitis; Fluorescein-5-isothiocyanate; Genes, | 2009 |
Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat.
Topics: Aging; Animals; Brain Injuries; Cell Count; Cell Death; Hippocampus; Immunohistochemistry; Male; Neu | 2009 |
Sialic acid feeding aged rats rejuvenates stimulated salivation and colon enteric neuron chemotypes.
Topics: Aging; Animals; Brain Chemistry; Colon; Dietary Supplements; Drug Evaluation, Preclinical; Eating; E | 2009 |
Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Apoptosis; Apoptosis Regulatory Proteins; Calbin | 2010 |
Inflammation enhances epileptogenesis in the developing rat brain.
Topics: Age Factors; Aging; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy; Gliosis; Inflamma | 2010 |
Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Blood Glucose; Disease Models, Animal; Epilepsy, | 2011 |
Are morphologic and functional consequences of status epilepticus in infant rats progressive?
Topics: Aggression; Aging; Animals; Animals, Newborn; Antimanic Agents; Atrophy; Behavior, Animal; Brain; Ce | 2013 |
Epileptogenesis during development: injury, circuit recruitment, and plasticity.
Topics: Aging; Animals; Animals, Newborn; Convulsants; Dentate Gyrus; Electric Stimulation; Hippocampus; Imm | 2002 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; | 2002 |
Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent.
Topics: Aging; Animals; Brain; Cerebral Cortex; Disease Susceptibility; Lithium; Pilocarpine; Rats; Status E | 2003 |
Long-term changes in susceptibility to pilocarpine-induced status epilepticus following neocortical injuries in the rat at different developmental stages.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain Injuries; Disease Susceptibility; Drug Res | 2003 |
EFFECT OF CORTICOSTEROIDS ON INTRAOCULAR PRESSURE AND FLUID DYNAMICS. II. THE EFFECT OF DEXAMETHASONE IN THE GLAUCOMATOUS EYE.
Topics: Acetazolamide; Aging; Aqueous Humor; Dexamethasone; Epinephrine; Eye Diseases; Glaucoma; Glucocortic | 1963 |
EVALUATION OF THE SWEAT CHLORIDE ASSAY IN ADULTS: USE OF PILOCARPINE IONTOPHORESIS.
Topics: Adolescent; Adult; Aging; Child; Chlorides; Cystic Fibrosis; Humans; Infant; Iontophoresis; Lung Dis | 1963 |
THE EFFECT OF EXTERNAL COMPRESSION OF THE EYE ON INTRAOCULAR PRESSURE. II. RECOVERY: TONOGRAPHIC CHANGES AND THE INFLUENCE OF PHARMACOLOGIC AGENTS.
Topics: Acetazolamide; Aging; Atropa belladonna; Eye Diseases; Geriatrics; Humans; Intraocular Pressure; Man | 1963 |
INTRAMUSCULARLY ADMINISTERED ATROPINE AND THE EYE.
Topics: Accommodation, Ocular; Aging; Atropine; Cataract Extraction; Eye; Geriatrics; Glaucoma; Humans; Intr | 1964 |
THE IMPACT OF GEL ELECTROPHORESIS UPON OUR UNDERSTANDING OF THE ESTERASES.
Topics: Aging; Animals; Blood; Blood Proteins; Duodenum; Electrophoresis; Esterases; Female; Hepatectomy; Li | 1964 |
Pilocarpine prevents age-related spatial learning impairments in rats.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Male; Maze Learning; Memory; Muscarinic Agonists; | 2005 |
Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Blotting, Western; Brain; Calcium; Calcium-Calmodulin | 2005 |
Pilocarpine improves olfactory discrimination and social recognition memory deficits in 24 month-old rats.
Topics: Aging; Animals; Discrimination, Psychological; Injections, Intraperitoneal; Male; Memory Disorders; | 2006 |
Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.
Topics: Aging; Animals; Animals, Newborn; Auditory Perception; Brain Mapping; Cell Survival; Discrimination | 2005 |
The Na+/K+ATPase activity is increased in the hippocampus after multiple status epilepticus induced by pilocarpine in developing rats.
Topics: Aging; Animals; Animals, Newborn; Hippocampus; Pilocarpine; Rats; Rats, Wistar; Recurrence; Sodium-P | 2007 |
Changes of cortical epileptic afterdischarges after status epilepticus in immature rats.
Topics: Aging; Animals; Cerebral Cortex; Convulsants; Electric Stimulation; Electroencephalography; Epilepsy | 2008 |
Lens diameter and thickness as a function of age and pharmacologically stimulated accommodation in rhesus monkeys.
Topics: Accommodation, Ocular; Aging; Animals; Lens, Crystalline; Macaca mulatta; Miotics; Monkey Diseases; | 2008 |
The ionic composition of pilocarpine induced sweat in relation to gland output during aging and in cystic fibrosis.
Topics: Adolescent; Adult; Aging; Calcium; Child; Child, Preschool; Chlorides; Cystic Fibrosis; Female; Huma | 1967 |
Submandibular gland secretory function in young adult and aged rats.
Topics: Aging; Animals; Female; Glucose; Male; Pilocarpine; Potassium; Proteins; Rats; Rats, Inbred Strains; | 1984 |
Acute shallowing of the anterior chamber.
Topics: Acetazolamide; Aged; Aging; Anterior Chamber; Glaucoma; Humans; Intraocular Pressure; Iris; Middle A | 1981 |
Pilocarpine and narrow-angle glaucoma.
Topics: Adult; Aged; Aging; Anterior Chamber; Eye Color; Glaucoma; Humans; Middle Aged; Pilocarpine | 1981 |
Sustained effects of pilocarpine-induced convulsions on brain inositol and inositol monophosphate levels and brain morphology in young and old male rats.
Topics: Aging; Animals; Brain; Inositol; Inositol Phosphates; Male; Neurons; Pilocarpine; Rats; Rats, Wistar | 1993 |
The effect of propranolol on salivary gland function and dental caries development in young and aged rats.
Topics: Aging; Alveolar Bone Loss; Animals; Dental Caries; Dental Caries Susceptibility; Dental Plaque; Diet | 1993 |
Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cerebral Ventricles; Dizocilpin | 1993 |
Effects of subchronic administration of pyritinol on receptor deficits and phosphatidylinositol metabolism in the brain of the aged mouse.
Topics: Aging; Animals; Brain; Brain Chemistry; Carbachol; Female; Kinetics; Mice; Neurons; Phosphatidylinos | 1993 |
Aging effects on accommodation and outflow facility responses to pilocarpine in humans.
Topics: Accommodation, Ocular; Adult; Aged; Aging; Aqueous Humor; Ciliary Body; Female; Humans; Intraocular | 1996 |
Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study.
Topics: Aging; Animals; Brain Chemistry; Electroencephalography; Excitatory Amino Acid Agonists; Extracellul | 1997 |
Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Glucose; Lactic Acid; Lithium; Male; Nerv | 1999 |
Age-related changes in human ciliary muscle.
Topics: Accommodation, Ocular; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Atropine; Cadaver; Child; | 2000 |
Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss.
Topics: Aging; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Lithium; Male; | 2001 |
Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Cerebrovascular Circulation; Drug Synergi | 2002 |
Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Brain; Caspase 3; Caspases; Cholinergic Agents; | 2002 |
Changes in mouse sudomotor function and sweat gland innervation with ageing.
Topics: Acetylcholine; Aging; Animals; Axons; Cholinergic Agents; Down-Regulation; Female; Immunohistochemis | 2002 |
Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats.
Topics: Aging; Aminophylline; Animals; Cell Differentiation; Cognition Disorders; Growth Cones; Hippocampus; | 2002 |
Postnatal development of dopaminergic and cholinergic catalepsy in the rat.
Topics: Aging; Animals; Butyrophenones; Catalepsy; Catecholamines; Female; Humans; Male; Neurons; Pilocarpin | 1976 |
Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats.
Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Chlorides; Drug Administration Schedule; Electroe | 1992 |
Beta-adrenergic receptors and salivary gland secretion during aging.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Female; Iodocyanopindolol; Isoproterenol; Pilocarp | 1992 |
A biochemical analysis of parotid and submandibular salivary gland function with age after simultaneous stimulation with pilocarpine and isoproterenol in female NIA Fischer 344 rats.
Topics: Aging; alpha-Amylases; Animals; DNA; Epidermal Growth Factor; Female; Isoproterenol; Parotid Gland; | 1992 |
Age-related loss of ciliary muscle mobility in the rhesus monkey. Role of the choroid.
Topics: Aging; Animals; Atropine; Choroid; Ciliary Body; Female; Macaca mulatta; Male; Muscles; Neuromuscula | 1992 |
Combination of atipamezole and tetrahydroaminoacridine/pilocarpine treatment suppresses high voltage spindle activity in aged rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Drug Combinations; Electrophysiology; Imidazoles; Male | 1991 |
Effects of alpha 2-drugs and pilocarpine on the high-voltage spindle activity of young and aged control and DSP4-lesioned rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Benzylamines; Brain Mapping; Electroencephalography; E | 1991 |
Increased mucin levels in submandibular glands of aged male mice after chronic isoproterenol treatment.
Topics: Aging; Analysis of Variance; Animals; Circadian Rhythm; Female; Injections, Intraperitoneal; Isoprot | 1991 |
Agonist-induced Ca2+ mobilization in the rat submandibular gland during aging and subsequent to chronic propranolol treatment.
Topics: Aging; Animals; Calcium; Carbachol; Female; In Vitro Techniques; Intracellular Fluid; Isoproterenol; | 1991 |
[The effect of ageing on the active sweat gland density in the dorsum of foot].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Female; Foot; Humans; Male; Middle Aged; P | 1991 |
Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate.
Topics: Aging; Alanine; Animals; Antidepressive Agents; Electroencephalography; Electrophysiology; Imidazole | 1991 |
The effect of light intensity and dose of dilute pilocarpine eyedrops on pupillary constriction in healthy subjects.
Topics: Adult; Aging; Dose-Response Relationship, Drug; Female; Humans; Light; Male; Middle Aged; Ophthalmic | 1991 |
Tetrahydroaminoacridine inhibits high voltage spindle activity in aged rats after acute and chronic treatment.
Topics: Aging; Animals; Brain; Cholinesterases; Electroencephalography; Electrophysiology; Female; Pilocarpi | 1991 |
Outflow facility and its response to pilocarpine decline in aging rhesus monkeys.
Topics: Accommodation, Ocular; Aging; Animals; Aqueous Humor; Carbachol; Ciliary Body; Macaca mulatta; Oculo | 1991 |
Drug-induced xerostomia.
Topics: Adolescent; Aged; Aging; Female; Humans; Male; Middle Aged; Pilocarpine; Saliva, Artificial; Xerosto | 1991 |
[Pupil--recent development of investigation].
Topics: Adolescent; Adult; Aged; Aging; Brain Death; Child; Female; Humans; Male; Middle Aged; Photic Stimul | 1990 |
Age-related modulatory activity by a cholinergic agonist on the growth hormone response to GH-releasing hormone in the rat.
Topics: Aging; Animals; Growth Hormone; Growth Hormone-Releasing Hormone; Hypothalamus; Male; Pilocarpine; R | 1990 |
Changes in sudomotor nerve territories with aging in the mouse.
Topics: Aging; Animals; Electric Stimulation; Female; Foot; Mice; Mice, Inbred Strains; Peripheral Nerves; P | 1990 |
[A re-evaluation of pupillary sensitivity to autonomics in diabetic patients].
Topics: Administration, Topical; Adult; Aging; Anterior Chamber; Diabetes Mellitus; Diabetic Retinopathy; Fl | 1990 |
IgG in murine intestinal secretions. Aging effect and possible physiological role.
Topics: Aging; Animals; Antibody Specificity; Antigens, Bacterial; Binding Sites, Antibody; Enterobacter; Es | 1989 |
Effect of age on cholinergic muscarinic responsiveness and receptors in the rat urinary bladder.
Topics: Acetylcholine; Aging; Animals; Atropine; Bethanechol; Bethanechol Compounds; Male; Muscle Contractio | 1986 |
Age changes in secretory function of male and female rat parotid glands in response to methoxamine and pilocarpine.
Topics: Aging; Animals; Body Weight; Electrophoresis; Female; Male; Methoxamine; Parotid Gland; Pilocarpine; | 1988 |
Age-related loss of morphologic responses to pilocarpine in rhesus monkey ciliary muscle.
Topics: Administration, Topical; Aging; Animals; Atropine; Macaca mulatta; Muscle Contraction; Oculomotor Mu | 1988 |
Effect of age on collateral reinnervation of sweat glands in the mouse.
Topics: Aging; Animals; Axons; Female; Hindlimb; Mice; Nerve Regeneration; Peripheral Nerves; Pilocarpine; S | 1988 |
[Age-related modification of dopaminergic-cholinergic neuronal interaction in rats].
Topics: Aging; Animals; Apomorphine; Drug Interactions; Male; Methyltyrosines; Physostigmine; Pilocarpine; R | 1988 |
Effect of age and maturation on sudomotor nerve regeneration in mice.
Topics: Aging; Animals; Axons; Hindlimb; Hot Temperature; Mice; Motor Neurons; Nerve Regeneration; Pilocarpi | 1988 |
The susceptibility of rats to pilocarpine-induced seizures is age-dependent.
Topics: Aging; Animals; Behavior, Animal; Brain; Disease Susceptibility; Electroencephalography; Female; Mal | 1987 |
Characteristics of stimulated parotid gland secretion in the aging rat.
Topics: Aging; Animals; Body Water; Female; Male; Parotid Gland; Pilocarpine; Potassium; Rats; Rats, Inbred | 1985 |
[The autonomic nervous system and aging].
Topics: Aged; Aging; Analysis of Variance; Atropine; Autonomic Nervous System; Autonomic Nervous System Dise | 1985 |
Effects of cholinomimetic agents given into the brain of fowls.
Topics: Acetylcholine; Aging; Animals; Behavior, Animal; Benzoates; Body Temperature; Carbachol; Cerebral Ve | 1974 |
[Age and sympathetic activity (author's transl)].
Topics: Adolescent; Adult; Aged; Aging; Animals; Catecholamines; Hemodynamics; Humans; Norepinephrine; Piloc | 1974 |
[Accommodation in presbyopics influenced by aging and extensive medication].
Topics: Accommodation, Ocular; Adult; Aging; Female; Humans; Male; Middle Aged; Ophthalmic Solutions; Piloca | 1971 |