pilocarpine has been researched along with Absence Status in 1003 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "PT after SE reduces the recurrent seizures and improves the morphological, biochemical and cognitive profiles of pilocarpine epileptic models." | 8.95 | Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models. ( Chen, XL; Iqbal, M; Liu, JX; Liu, Y; Rahman, MS; Zafar, S, 2017) |
| "The pilocarpine-induced (PILO) model has helped elucidate the electrophysiological and molecular aspects related to mesial temporal lobe epilepsy." | 8.31 | Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival. ( Athié, MCP; Cavalheiro, EA; Cendes, F; Conte, FF; Covolan, L; Gilioli, R; Lopes-Cendes, I; Malheiros, JM; Marchesini, RB; Matos, AHB; Pascoal, LB; Pascoal, VDB; Pereira, TC; Polli, RS; Secolin, R; Tannús, A; Vieira, AS, 2023) |
| "The blockage of transient receptor potential vanilloid 4 (TRPV4) inhibits inflammation and reduces hippocampal neuronal injury in a pilocarpine-induced mouse model of temporal lobe epilepsy." | 8.31 | Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus. ( An, D; Chen, L; Chen, X; Du, Y; Li, K; Qi, X; Sha, S; Wang, Y; Wu, C; Xu, W, 2023) |
| "The present study aims to formulate and evaluate the efficacy of chrysin-loaded nanoemulsion (CH NE) against lithium/pilocarpine-induced epilepsy in rats, as well as, elucidate its effect on main epilepsy pathogenesis cornerstones; neuronal hyperactivity, oxidative stress, and neuroinflammation." | 8.31 | Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway. ( Ahmed, N; Ahmed, Y; Alshafei, H; Alshafei, R; Ashraf, N; El-Derany, MO; Ezz, S; George, MY; Ibrahim, C; Ibrahim, SS; Khaled, G; Khaled, H; Saleh, A; Waleed, H; Zaher, M, 2023) |
| "The anticonvulsant and antioxidant effects of lamotrigine on status epilepticus (SE) are incompletely understood." | 8.31 | Anticonvulsant and antioxidant effects of lamotrigine on pilocarpine-induced status epilepticus in mice. ( Fujiki, M; Kamida, T; Momii, Y; Onishi, K; Sugita, K, 2023) |
| "Status epilepticus (SE) triggered by lithium-pilocarpine is a model of epileptogenesis widely used in rats, reproducing many of the pathological features of human temporal lobe epilepsy (TLE)." | 8.31 | The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection. ( Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MÁ, 2023) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 8.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| "The objective of this work was to evaluate the antiseizure effect of the antioxidants allopurinol (ALL) and ellagic acid during status epilepticus induced by pilocarpine (PILO)." | 8.31 | Allopurinol and ellagic acid decrease epileptiform activity and the severity of convulsive behavior in a model of status epilepticus. ( Martínez-Gallegos, S; Medina-Ceja, L; Pardo-Peña, K; Sánchez-Lira, A, 2023) |
| " In this study, we investigated the anti-inflammatory action of eugenol in an experimental epilepsy model of pilocarpine-induced status epilepticus (SE)." | 8.31 | Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus. ( Jeong, KH; Kim, CH; Kim, WJ; Park, S; Zhu, J, 2023) |
| "The authors investigated changes in vascular reactivity in rats following pilocarpine-induced status epilepticus." | 8.31 | Reduction of vascular reactivity in rat aortas following pilocarpine-induced status epilepticus. ( Cavalheiro, EA; Nunes, KZ; Scorza, FA; Vassallo, DV, 2023) |
| " U50488, a selective KOR agonist is used to determine its effect on status epilepticus (SE), spontaneous convulsive seizures (SS) and cognitive impairment in rat lithium-pilocarpine SE model." | 8.31 | Effect of U50488, a selective kappa opioid receptor agonist and levetiracetam against lithium-pilocarpine-induced status epilepticus, spontaneous convulsive seizures and related cognitive impairment. ( Katyal, J; Kumar Gupta, Y; Kumar, H, 2023) |
| " A single, systemic dose of mefloquine administered early after pilocarpine-induced status epilepticus (SE) in rat reduced both development of SRS and behavioral co-morbidities." | 8.31 | Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus. ( Santhakumar, V; Shao, M; Yu, H; Yu, J, 2023) |
| " Using a pilocarpine-induced mice model of epilepsy, we showed that Gpc4 expression was significantly increased in the stratum granulosum of the dentate gyrus at 1 week after status epilepticus (SE)." | 8.12 | Neuronal Glypican4 promotes mossy fiber sprouting through the mTOR pathway after pilocarpine-induced status epilepticus in mice. ( Hu, HB; Ji, C; Liu, JX; Ma, KG; Ma, YB; Peng, SM; Ren, LD; Si, KW; Wu, F; Wu, XL; Xiao, XL; Yan, QS; Yang, BN; Zhou, JS, 2022) |
| "Only few studies have focus on animals that received Pilocarpine (Pilo) and did not develop behavioral status epilepticus (SE) and, whether they may become epileptic in the model's chronic phase." | 8.12 | Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. ( Amado, D; Amorim, RP; Cossa, AC; da Silva, JC; Dal Pai, J; Predebon, G; Sanabria, V; Trindade-Filho, E, 2022) |
| " In the present study, we aimed to investigate the effects of adjudin on pilocarpine-induced status epilepticus (SE) and its role in the regulation of reactive gliosis and neuroinflammation." | 8.12 | Adjudin prevents neuronal damage and neuroinflammation via inhibiting mTOR activation against pilocarpine-induced status epilepticus. ( Jeong, KH; Kim, WJ; Park, S; Zhu, J, 2022) |
| "LiCl/pilocarpine status epilepticus (SE) induced in immature rats leads, after a latent period, to hippocampal hyperexcitability." | 8.12 | Adenosine Kinase Isoforms in the Developing Rat Hippocampus after LiCl/Pilocarpine Status Epilepticus. ( Fábera, P; Kubová, H; Mareš, P; Tsenov, G; Uttl, L, 2022) |
| "Beta-caryophyllene-treated animals presented fewer short-term recurrent seizures than vehicle-treated counterparts, suggesting an anticonvulsant effect after SE." | 8.12 | Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats. ( da Costa Sobral, KG; Fighera, MR; Furian, AF; Mallmann, MP; Mello, FK; Neuberger, B; Oliveira, MS; Royes, LFF, 2022) |
| ") was administered 3 h after the pilocarpine (pilo)-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 8.12 | The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats. ( Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| "Morphine is widely used in patients and has been reported to alter seizure threshold, but its role in the development of epilepsy is unknown." | 8.12 | Effect of morphine administration after status epilepticus on epileptogenesis in rats. ( Gupta, YK; Joshi, D; Katyal, J; Kumar, H, 2022) |
| " The objective of the current study was to investigate the effects of endurance training, applied before and after pilocarpine (Pilo) administration, on status epilepticus (SE) severity, and its relation to epileptogenesis deleterious consequences during the chronic epileptic phase." | 8.12 | Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. ( Atanasova, M; Georgieva, K; Ioanidu, L; Nenchovska, Z; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| " Therefore, we investigated the expression pattern of GRIM-19 in the CA1 area of the hippocampus in 8-week-old male C57BL/6 mice following pilocarpine-induced status epilepticus (SE)." | 7.96 | Alteration of Gene Associated with Retinoid-interferon-induced Mortality-19-expressing Cell Types in the Mouse Hippocampus Following Pilocarpine-induced Status Epilepticus. ( Hwang, SN; Kim, JC; Kim, SY, 2020) |
| " Here, in this study, we observed a significant increase in neuroinflammation and in the proliferation and survival of newborn granular cells in the hippocampus of pilocarpine-induced status epilepticus (SE) mice." | 7.96 | Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice. ( Gan, G; Ge, Q; Liu, X; Niu, D; Yang, J; Yao, H; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2020) |
| " Therefore, in the present study, we investigated the expression of parvalbumin (PV), one of the calcium-binding proteins, and morphological changes in the rat main olfactory bulb (MOB) following pilocarpine- induced status epilepticus (SE)." | 7.96 | Altered expression of parvalbumin immunoreactivity in rat main olfactory bulb following pilocarpine-induced status epilepticus. ( Kim, DS; Park, DK; Yoo, DY; Yu, YH, 2020) |
| " In the study, we established a mouse model of status epilepticus (SE) with pilocarpine and a cell model of TLE." | 7.96 | Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice. ( Chen, C; Cheng, X; Lian, Y; Xie, N; Xu, H; Zhang, H; Zheng, Y, 2020) |
| " To investigate role of miRNA in the latent stage following status epilepticus, we first compared microRNA expression profiles in mice hippocampus at 1 week after pilocarpine-induced status epilepticus (SE) vs." | 7.96 | Identification of microRNA-target genes in mice hippocampus at 1 week after pilocarpine-induced status epilepticus. ( Liu, JX; Liu, LF; Ma, YB; Si, KW; Tan, J; Tong, H; Wu, XL; Xiao, XL; Zhou, JS, 2020) |
| "The present study aimed to evaluate the effect of topiramate (TPM) and lacosamide (LCM) on the emotional and cognitive re-sponses in naive animals and in animals with pilocarpine-induced status epilepticus." | 7.96 | The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model. ( Georgieva, K; Ivanova, N; Nenchovska, Z; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J, 2020) |
| "Rosiglitazone reverses microglial polarization in the brains of SE mice and also affords neuroprotection against pilocarpine-induced status epilepticus without inducing significant changes in brain inflammation." | 7.91 | Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus. ( Guan, Y; Hao, Y; Li, Y; Peng, J; Wang, K; Xiang, W, 2019) |
| " We followed up progressive preclinical investigation in mice against pilocarpine (PILO)-induced status epilepticus (SE) and temporal lobe epilepsy (TLE)." | 7.91 | The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. ( Alam, MS; Ansari, MA; Ashraf, GM; Barkat, MA; Barreto, GE; Javed, MN; Khan, A; Maqbool, A; Nigar, S; Pottoo, FH; Rasheed, R; Tabassum, N, 2019) |
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 7.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| " We aim in this study to investigate the neuroprotective effects of GL in a rat model after lithium-pilocarpine-induced status epilepticus (SE)." | 7.91 | Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus. ( Gao, F; Li, YJ; Wang, L; Yang, CM; Zhang, B, 2019) |
| " Next, we tested an intravenous preparation of CBD (10 mg/kg single dose) in a rat model of pilocarpine-induced status epilepticus." | 7.91 | Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. ( Barker-Haliski, M; Bazelot, M; Glyn, S; Jones, N; McNeish, AJ; Patra, PH; Sandhu, H; Whalley, BJ; White, HS; Williams, CM, 2019) |
| "To investigate possible correlations between serum S100B levels and microglial/astrocytic activation in status epilepticus (SE) in lithium-pilocarpine-exposed rat hippocampi and whether serum S100B levels linearly reflect neuroinflammation." | 7.91 | The Effects of Minocycline on the Hippocampus in Lithium- Pilocarpine Induced Status Epilepticus in Rat: Relations with Microglial/Astrocytic Activation and Serum S100B Level. ( Atilla, P; Aydemir, O; Barun, S; Bulduk, EB; Kiziltas, M; Kurt, G; Muftuoglu, S; Oktem, M; Turhan, T, 2019) |
| " We investigated the effect of early administration of endocannabinoid receptor agonist WIN-55,212-2 on the development of spontaneous seizures, long-term behavioral and memory impairments, and neurodegeneration in the hippocampus on the lithium-pilocarpine model of status epilepticus (SE)." | 7.91 | Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model. ( Borisova, MA; Suleymanova, EM; Vinogradova, LV, 2019) |
| " Status epilepticus (SE) was induced via systemic injection of pilocarpine." | 7.91 | Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment. ( Huang, H; Huang, M; Lin, R; Lin, W; Liu, C; Ma, Y; Wen, Y, 2019) |
| " Accordingly, in the present study, we sought to explore whether TRPV4 is involved in the regulation of Cx expression following pilocarpine-induced status epilepticus (PISE) in mice." | 7.91 | Transient receptor potential vanilloid 4 is involved in the upregulation of connexin expression following pilocarpine-induced status epilepticus in mice. ( An, D; Chen, L; Men, C; Qi, M; Wang, Z; Xu, W; Zhan, Y; Zhou, L, 2019) |
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 7.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| " Here, we investigated the effects of triheptanoin against changes of hippocampal mitochondrial functions, oxidative stress and cell death induced by pilocarpine-induced status epilepticus (SE) in mice." | 7.88 | Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. ( Borges, K; Carrasco-Pozo, C; Simmons, D; Tan, KN, 2018) |
| " This study aimed to investigate the role of mitochondrial Rho (Miro) 1 in epilepsy, using a mouse model of pilocarpine-induced status epilepticus (SE)." | 7.88 | Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy. ( Lian, Y; Xie, N; Zhang, H; Zheng, Y, 2018) |
| "Although convulsive seizures occurring during pilocarpine-induced epileptogenesis have received considerable attention, nonconvulsive seizures have not been closely examined, even though they may reflect the earliest signs of epileptogenesis and potentially guide research on antiepileptogenic interventions." | 7.88 | Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus. ( Barth, DS; Benison, AM; Bercum, FM; Dudek, FE; Smith, ZZ, 2018) |
| " In this study, the expression of Cx36 was investigated in the mouse hippocampus at 1 h, 4 h during pilocarpine-induced status epilepticus (PISE) and 1 week, 2 months after PISE." | 7.88 | Cx36 in the mouse hippocampus during and after pilocarpine-induced status epilepticus. ( Huo, YW; Lu, M; Ma, DM; Tang, FR; Wu, XL; Zhang, W; Zhou, JS, 2018) |
| " The present pilot study aims to investigate whether liraglutide alleviates the chronic inflammation response and mitochondrial stress induced by SE in the lithium-pilocarpine animal model." | 7.88 | Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. ( Feng, P; Hölscher, C; Li, DF; Tian, MJ; Wang, RF; Xue, GF; Zheng, JY, 2018) |
| "Currently, lacosamide (LCM) is not approved for use in status epilepticus (SE) but several shreds of evidence are available to support its use." | 7.88 | Inverted-U response of lacosamide on pilocarpine-induced status epilepticus and oxidative stress in C57BL/6 mice is independent of hippocampal collapsin response mediator protein-2. ( Nirwan, N; Siraj, F; Vohora, D, 2018) |
| "To investigate the spatiotemporal expression of cannabinoid receptor type 2 (CB2R) in the hippocampus of pilocarpine-treated rats experiencing a status epilepticus (SE)." | 7.88 | The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus. ( Wang, H; Wu, Q, 2018) |
| " Thus, we evaluated SV2A protein expression throughout the hippocampi of lithium-pilocarpine rats after status epilepticus (SE) and during early and late epilepsy." | 7.88 | Differential expression of synaptic vesicle protein 2A after status epilepticus and during epilepsy in a lithium-pilocarpine model. ( Contreras-García, IJ; Gómez-González, B; Mendoza Torreblanca, JG; Pichardo-Macías, LA; Ramírez-Hernández, R; Rocha, L; Sánchez-Huerta, K; Santana-Gómez, CE, 2018) |
| " This study aims at investigating AO effects on (i) latency to first seizure, seizure severity, weight loss, mortality rate, (ii) lipid peroxidation level, nitrite level, and catalase activity in the hippocampus after SE induced by pilocarpine (PC)." | 7.88 | Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats. ( Ammouri, H; Bahbiti, Y; Berkiks, I; Bikjdaouene, L; Chakit, M; Hessni, AE; Mesfioui, A; Nakache, R; Ouichou, A, 2018) |
| "The status epilepticus (SE) induced by lithium-pilocarpine is a well characterized rodent model of the human temporal lobe epilepsy (TLE) which is accompanied by severe brain damage." | 7.85 | Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model. ( Bankstahl, JP; Bascuñana, P; Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MA; Shiha, AA; Silván, Á, 2017) |
| " We have investigated whether the intrinsic firing response gain, quantified by the slope of the function relating the number of evoked spikes (Ns) to input excitatory current intensity (I), is modified in principal rat hippocampal neurons in the pilocarpine-status epilepticus (SE) model of TLE." | 7.85 | Plasticity of intrinsic firing response gain in principal hippocampal neurons following pilocarpine-induced status epilepticus. ( Daninos, M; Tamir, I; Yaari, Y, 2017) |
| "This study aims to investigate the role of zolpidem in lithium-pilocarpine induced status epilepticus (SE) and probable mechanisms involved in seizure threshold alteration." | 7.85 | Involvement of nitrergic system in anticonvulsant effect of zolpidem in lithium-pilocarpine induced status epilepticus: Evaluation of iNOS and COX-2 genes expression. ( Bahremand, T; Dehpour, AR; Eslami, SM; Ghasemi, M; Gholami, M; Momeny, M; Sharifzadeh, M, 2017) |
| " In order to delineate the immune response following pilocarpine-induced status epilepticus (SE) in the mouse, we monitored the kinetics of leukocyte presence in the hippocampus over the period of four weeks." | 7.85 | Mycophenolate mofetil prevents the delayed T cell response after pilocarpine-induced status epilepticus in mice. ( Abele, J; Engelmann, R; Kirschstein, T; Köhling, R; Müller-Hilke, B; Neumann, AM; Sellmann, T, 2017) |
| " When the brain slices were prepared from mice which underwent a pilocarpine-induced status epilepticus or when brain slices were incubated in pilocarpine-containing external medium, the sensitivity of P2X7 and P2Y1 receptors was invariably increased." | 7.85 | Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus. ( Araújo, MGL; Fernandes, MJS; Franke, H; Gao, P; Illes, P; Khan, MT; Krügel, U; Liu, J; Rong, W; Rozmer, K; Tang, Y, 2017) |
| " By utilizing a combination of behavioral surveys, immunofluorescence and electrophysiological recordings, the present study characterized the anticonvulsant effect of GAS in a pilocarpine-induced status epilepticus (SE) rat model of TLE and explored the underlying cellular mechanisms." | 7.85 | Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents. ( Cao, XY; Hong, P; Ji, WG; Qi, AP; Shao, H; Yang, Y; Zhu, GX; Zhu, ZR, 2017) |
| " In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE)." | 7.85 | TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice. ( Abramowitz, J; Birnbaumer, L; Cozart, MA; Mock, MM; Phelan, KD; Shwe, UT; Wu, H; Zheng, F, 2017) |
| " We hypothesized that pilocarpine-induced status epilepticus would disrupt oscillations and behavioral performance and that electrical neuromodulation to entrain theta would improve cognition specifically in injured rats." | 7.85 | Stimulation of the medial septum improves performance in spatial learning following pilocarpine-induced status epilepticus. ( Echeverri, A; Gurkoff, GG; Izadi, A; Lee, DJ; Melnik, M; Seidl, S; Shahlaie, K, 2017) |
| "This study aimed to determine the role C5aR1 plays in mediating immune responses acutely after pilocarpine-induced status epilepticus (SE), specifically those of brain-infiltrating leukocytes." | 7.85 | The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus. ( Benson, MJ; Borges, K; Manzanero, S, 2017) |
| "The intracranial EEG was continuously registered in Krushinskii-Molodkina rats with inherited susceptibility to audiogenic seizures and in Wistar rats, which are resistant to the audiogenic convulsions in the lithium-pilocarpine model of status epilepticus (SE)." | 7.83 | [CHANGES IN BRAIN ELECTRICAL ACTIVITY PATTERNS IN RATS WITH DIFFERENT SUSCEPTIBILITY TO SEIZURES IN LITHIUM-PILOCARPINE MODEL OF STATUS EPILEPTICUS]. ( Kim, KK; Lukomskaya, NY; Magazanik, LG; Vataev, SI; Zaitsev, AV, 2016) |
| "It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium-pilocarpine model of status epilepticus (SE) in rats." | 7.83 | Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2016) |
| " In the present study, we examined the time-course changes of neuronal degeneration and hippocalcin protein level in the mouse hippocampus following pilocarpine-induced status epilepticus (SE)." | 7.83 | Time-course changes of hippocalcin expression in the mouse hippocampus following pilocarpine-induced status epilepticus. ( Choi, HS; Lee, CH, 2016) |
| " During status epilepticus, ACh levels were increased threefold but returned to baseline after the termination of seizures by diazepam." | 7.83 | Extracellular levels of ATP and acetylcholine during lithium-pilocarpine induced status epilepticus in rats. ( Imran, I; Klein, J; Lietsche, J, 2016) |
| " In the present study the pilocarpine-induced status epilepticus (SE) model of TLE was used to study the regulation of CRTC1 during and following SE." | 7.83 | CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy. ( Dubey, D; Porter, BE, 2016) |
| " Herein, we confirmed that pilocarpine application promptly (<30 min) induces status epilepticus (SE) as revealed by changes in rat electrocorticogram particularly in fast-beta range (21-30 Hz)." | 7.83 | Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons. ( Britto, LR; Damico, MV; de Sousa, E; Higa, GS; Kihara, AH; Kinjo, ER; Morya, E; Santos, BA; Valle, AC; Walter, LT, 2016) |
| " We performed long-term video-EEG monitoring of 16 epileptic rats after pilocarpine-induced status epilepticus and five control animals." | 7.83 | Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats. ( Bajorat, R; Brenndörfer, L; Goerss, D; Kirschstein, T; Köhling, R; Schwabe, L, 2016) |
| "5h with pilocarpine to study anxiety-related behaviors, changes in the electroencephalogram of the cerebral cortex and hippocampus, and expression of hippocampal proteins." | 7.83 | Dual mechanisms of rapid expression of anxiety-related behavior in pilocarpine-treated epileptic mice. ( Iida, Y; Itakura, M; Miyaoka, H; Ohkido, T; Otsuka, S; Saito, M; Takahashi, M; Watanabe, S; Yamamori, S, 2016) |
| " During pilocarpine induced status epilepticus, a transient down-regulation of neuronal CCR6 in the stratum oriens of CA1 was demonstrated at 2h during status epilepticus." | 7.83 | Altered expression of neuronal CCR6 during pilocarpine induced status epilepticus in mice. ( Cao, X; Liu, JX; Liu, Y; Tang, FR, 2016) |
| " The aims of the present study were to evaluate GL scavenging properties and to investigate GL's effect on oxidative stress and inflammation in the lithium/pilocarpine-induced seizure model in two cerebral regions, hippocampus and olfactory bulb, at acute time intervals (3 or 24h) after status epilepticus (SE)." | 7.83 | Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats. ( González-Reyes, S; Guevara-Guzmán, R; Jiménez-Osorio, AS; Pedraza-Chaverri, J; Santillán-Cigales, JJ, 2016) |
| " Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE." | 7.83 | Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. ( Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV, 2016) |
| "To study the effect of a microRNA-132 antagonist on lithium-pilocarpine-induced status epilepticus (SE) in young Sprague-Dawley (SD) rats." | 7.83 | [Effect of a microRNA-132 antagonist on pilocarpine-induced status epilepticus in young rats]. ( Kong, HM; Li, LH; Peng, J; Wu, TH; Yin, F, 2016) |
| " In the present study, we measured dendritic spine volume in mice injected with miR-134-targeting antagomirs and tested effects of the antagomirs on status epilepticus triggered by the cholinergic agonist pilocarpine." | 7.81 | Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus. ( Conroy, RM; deFelipe, J; Engel, T; Fernaud-Espinosa, I; Henshall, DC; Jimenez-Mateos, EM; McKiernan, RC; Merino-Serrais, P; Reschke, CR; Reynolds, J; Rodriguez-Alvarez, N, 2015) |
| " We investigated the effects of ketogenic diets (KDs) containing coconut oil, triheptanoin, or soybean oil on pilocarpine-induced status epilepticus (SE) in rats." | 7.81 | Effects of ketogenic diets on the occurrence of pilocarpine-induced status epilepticus of rats. ( Barros, EM; Bueno, NB; Cabral-Junior, CR; da Rocha Ataide, T; Domingos, BR; Ferreira, RC; Galvão, JA; Gama, IR; Melo, IT; Oliveira, SL; Pereira, WS; Trindade-Filho, EM, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 7.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "Experiments were designed to evaluate changes in the histamine release, mast cell number and neuronal damage in hippocampus induced by status epilepticus." | 7.81 | The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus. ( Orozco-Suárez, SA; Rocha, L; Santana-Gómez, CE; Valle-Dorado, MG, 2015) |
| " To further address this issue, we investigated the progressive changes of Cx 43 and Cx 40 in the mouse hippocampus at 4 h, 1 day, 1 week and 2 months during and after pilocarpine-induced status epilepticus (PISE)." | 7.81 | Astrocytic Cx 43 and Cx 40 in the mouse hippocampus during and after pilocarpine-induced status epilepticus. ( Lu, QY; Song, TB; Tang, FR; Tang, YC; Wu, XL; Xiao, XL, 2015) |
| "The aim of the present study was to evaluate the effects of transcranial focal electrical stimulation (TFS) on γ-aminobutyric acid (GABA) and glutamate release in the hippocampus under basal conditions and during pilocarpine-induced status epilepticus (SE)." | 7.81 | Transcranial focal electrical stimulation reduces the convulsive expression and amino acid release in the hippocampus during pilocarpine-induced status epilepticus in rats. ( Alcántara-González, D; Bañuelos-Cabrera, I; Besio, W; Fernández-Mas, R; Luna-Munguía, H; Magdaleno-Madrigal, V; Rocha, L; Santana-Gómez, CE, 2015) |
| " In this study, we found that the MCU inhibitor Ru360 significantly attenuated neuronal death and exerted an anti-apoptotic effect on rat hippocampal neurons after pilocarpine-induced status epilepticus (SE), while the MCU activator spermine increased seizure-induced neuronal death and apoptosis." | 7.81 | Role of the Mitochondrial Calcium Uniporter in Rat Hippocampal Neuronal Death After Pilocarpine-Induced Status Epilepticus. ( Ge, X; Li, Y; Wang, C; Wang, M; Wang, Y; Xie, N, 2015) |
| "The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy." | 7.81 | Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. ( Hillert, MH; Imran, I; Klein, J, 2015) |
| "Pilocarpine chemoconvulsant was used to induce status epilepticus." | 7.81 | Suppressing cAMP response element-binding protein transcription shortens the duration of status epilepticus and decreases the number of spontaneous seizures in the pilocarpine model of epilepsy. ( Bermudez, C; Dubey, D; Porter, BE; Zhu, X, 2015) |
| "Pilocarpine-induced status epilepticus (SE) is a widely used seizure model in mice, and the Racine scale has been used to index seizure intensity." | 7.81 | Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale. ( Greenfield, LJ; Phelan, KD; Shwe, UT; Williams, DK; Zheng, F, 2015) |
| "In a previous study, we reported a persistent reduction of F-actin puncta but a compensating increase in puncta size in the mouse hippocampus at 2 months after pilocarpine-induced status epilepticus (Epilepsy Res." | 7.81 | The progressive changes of filamentous actin cytoskeleton in the hippocampal neurons after pilocarpine-induced status epilepticus. ( Dai, G; Hou, Y; Li, S; Li, Y; Liu, H; Liu, J; Song, Y; Tan, B; Xiong, T; Zhang, Y, 2015) |
| "Pilocarpine-induced status epilepticus (SE), which results in temporal lobe epilepsy (TLE) in rodents, activates the JAK/STAT pathway." | 7.80 | The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. ( Brooks-Kayal, AR; Carlsen, J; Cogswell, M; Del Angel, YC; Grabenstatter, HL; Russek, SJ; Wempe, MF; White, AM, 2014) |
| "Status epilepticus (SE) was induced by intraperitoneal injection of 340mg/kg pilocarpine, and terminated by diazepam after 40min." | 7.80 | Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizures. ( Groeneweg, L; Kirschstein, T; Köhling, R; Müller, L; Müller, S; Sellmann, T; Tokay, T, 2014) |
| "We investigated localization of Phospholipase C beta (PLCβ1 and PLCβ4) in laminaes of dorsal hippocampus and different subtypes of hippocampal interneurons in normal Kunming mouse, and their progressive changes during pilocarpine induced status epilepticus (SE) by quantitative immunohistochemistry and real time PCR." | 7.80 | Reduced expression of Phospholipase C beta in hippocampal interneuron during pilocarpine induced status epilepticus in mice. ( Chen, XL; Hu, M; Liu, JX; Liu, Y; Xu, JH; Yang, PB; Zhang, JS, 2014) |
| " Thus, the aim of the present study was to evaluate the effect of sleep deprivation in the expression of microRNA (miRNA) in the frontal cortex and heart tissues of adult male rats after 50days of saline (SAL) or pilocarpine-induced status epilepticus (PILO)." | 7.80 | The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus. ( Andersen, ML; Cavalheiro, EA; Guindalini, C; Matos, G; Mazzotti, DR; Scorza, FA; Tufik, S, 2014) |
| " After pilocarpine-induced status epilepticus (SE), increases in neurotrophins regulate a wide variety of cell-signaling pathways, including prosurvival and cell-death machinery in a receptor-specific manner." | 7.80 | Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. ( Brooks-Kayal, AR; Carlsen, J; Cruz Del Angel, Y; Gonzalez, MI; Grabenstatter, HL; Hund, D; Longo, FM; Raol, YH; Russek, SJ; White, AM; Yang, T, 2014) |
| "The lithium-pilocarpine model is a rat model of epilepsy that mimics status epilepticus in humans." | 7.80 | Dynamics of hippocampal acetylcholine release during lithium-pilocarpine-induced status epilepticus in rats. ( Hillert, MH; Imran, I; Klein, J; Lau, H; Weinfurter, S; Zimmermann, M, 2014) |
| " Activity of Na(+),K(+)-ATPase decreased in the hippocampus of C57BL/6 mice 60 days after pilocarpine-induced status epilepticus (SE)." | 7.80 | Long-term decrease in Na+,K+-ATPase activity after pilocarpine-induced status epilepticus is associated with nitration of its alpha subunit. ( de Oliveira, CV; Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, MS; Pereira, LM; Ribeiro, LR; Royes, LF, 2014) |
| "Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin." | 7.80 | Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus. ( Argaãaraz, GA; Cavalheiro, EA; Graça Naffah-Mazzacoratti, Md; Perosa, SR; Silva, JA; Vieira, MJ, 2014) |
| "Levetiracetam has been reported to be well tolerated and effective in status epilepticus (SE) refractory to benzodiazepine." | 7.79 | The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus. ( Choi, HC; Kang, TC; Kim, JE; Kim, YI; Lee, DS; Ryu, HJ; Song, HK, 2013) |
| "Administration of carisbamate during status epilepticus (SE) prevents the occurrence of motor seizures in the lithium-pilocarpine model and leads in a subpopulation of rats to spike-and-wave discharges characteristic of absence epilepsy." | 7.79 | A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus. ( Akimana, G; Carneiro, JE; Cassel, JC; Cosquer, B; Faure, JB; Ferrandon, A; Geiger, K; Koning, E; Nehlig, A; Penazzi, L, 2013) |
| "Experiments were conducted to evaluate the effects of transcranial focal electrical stimulation (TFS) applied via tripolar concentric ring electrodes, alone and associated with a sub-effective dose of diazepam (DZP) on the expression of status epilepticus (SE) induced by lithium-pilocarpine (LP) and subsequent neuronal damage in the hippocampus." | 7.79 | Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats. ( Besio, W; Cuellar-Herrera, M; Luna-Munguia, H; Orozco-Suárez, S; Rocha, L, 2013) |
| " Here we report that both protein and mRNA levels of cortical and hippocampal PGRN are significantly enhanced following pilocarpine-induced status epilepticus." | 7.79 | Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. ( Chang, Q; Cynader, MS; Dong, Z; Jia, W; Leavitt, BR; Liao, C; MacVicar, BA; Petkau, TL; Tai, C; Tian Wang, Y; Wen, W; Zhang, S; Zhu, S, 2013) |
| " The present study used the lithium pilocarpine model of acquired epilepsy in immature animals to assess which structures outside the hippocampus are injured acutely after status epilepticus." | 7.79 | Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat. ( Dudek, FE; Ekstrand, JJ; Scholl, EA, 2013) |
| " In the present study, the PPARγ agonist rosiglitazone inhibited increases in BDNF and TrkB after status epilepticus (SE), and also prevented hippocampal neuronal loss." | 7.79 | The PPARγ agonist rosiglitazone prevents neuronal loss and attenuates development of spontaneous recurrent seizures through BDNF/TrkB signaling following pilocarpine-induced status epilepticus. ( GuiLian, Z; HaiQin, W; Hong, S; HuQing, W; Li, Y; Ning, B; Ru, Z; ShuQin, Z; Xin, Y; YongNan, L, 2013) |
| "6 (SCN8A) and its adapter protein ankyrin G in the AIS of the hippocampal cornu ammonis 3 (CA3) pyramidal cells of rat after status epilepticus induced by lithium-pilocarpine (PISE)." | 7.79 | Plasticity at axon initial segment of hippocampal CA3 neurons in rat after status epilepticus induced by lithium-pilocarpine. ( Feng, L; Li, AP; Long, LL; Sun, DN; Wang, MP; Wang, YL; Xiao, B, 2013) |
| "The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period." | 7.79 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| " In the present study, we demonstrate the presence of CD11c-positive DCs in the hippocampus, thalamus and temporal cortex following Li-pilocarpine induced status epilepticus (SE) in rats." | 7.79 | Brain recruitment of dendritic cells following Li-pilocarpine induced status epilepticus in adult rats. ( Jiang, W; Li, XW; Ma, L; Wang, JC; Wang, YG; Yang, F, 2013) |
| "This study aims to establish pilocarpine-induced rat model of status epilepticus (SE), observe the activity of calpain I in the rat hippocampus and the subsequent neuronal death, and explore the relationship between calpain I activity and neuronal death in the hippocampus." | 7.79 | Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model. ( Gao, H; Geng, Z, 2013) |
| " To better understand microRNA expression changes that might contribute to the development of epilepsy, microRNA arrays were performed on rat hippocampus 4 hours, 48 hours and 3 weeks following an episode of pilocarpine induced status epilepticus." | 7.79 | Changes in microRNA expression in the whole hippocampus and hippocampal synaptoneurosome fraction following pilocarpine induced status epilepticus. ( Porter, BE; Risbud, RM, 2013) |
| " Thus, we hypothesized that rosiglitazone, a PPARγ agonist, would prevent cognitive impairment by inhibiting astrocyte activation and regulating glutathione (GSH) homeostasis after status epilepticus (SE)." | 7.78 | The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus. ( GuiLian, Z; HaiQin, W; Hong, S; HuQing, W; Li, Y; Ru, Z; ShuQin, Z; Xin, Y; Yun, D, 2012) |
| "The pilocarpine-induced status epilepticus (SE) in rodents provides a valuable animal model of temporal lobe epilepsy." | 7.78 | The 27-kDa heat shock protein (HSP27) is a reliable hippocampal marker of full development of pilocarpine-induced status epilepticus. ( Bender, R; Glocker, MO; Kirschstein, T; Köhling, R; Kreutzer, M; Mikkat, S; Mikkat, U; Schulz, R, 2012) |
| " The effects of pilocarpine-induced status epilepticus (SE) and the subsequent spontaneous recurrent eizures on the number of GnRH-positive neurons were studied in adult female mice." | 7.78 | Pilocarpine-induced status epilepticus and subsequent spontaneous seizures: lack of effect on the number of gonadotropin-releasing hormone-positive neurons in a mouse model of temporal lobe epilepsy. ( Dudek, FE; Fawley, JA; Pouliot, WA, 2012) |
| "We investigated the cellular localization and progressive changes of corticotropin releasing factor (CRF) in the mouse hippocampus, during and after pilocarpine induced status epilepticus (PISE) and subsequent epileptogenesis." | 7.78 | Corticotropin releasing factor (CRF) in the hippocampus of the mouse pilocarpine model of status epilepticus. ( Ling, EA; Ma, DL; Tang, FR; Wu, J, 2012) |
| "Systemic injection of pilocarpine in rodents induces status epilepticus (SE) and reproduces the main characteristics of temporal lobe epilepsy (TLE)." | 7.78 | Consequences of pilocarpine-induced status epilepticus in immunodeficient mice. ( Coimbra, Rde C; Fernandes, MJ; Massironi, SG; Mazzacoratti, Mda G; Nehlig, A; Neto, EF; Persike, DS; Silva, IR; Vignoli, T, 2012) |
| " The present study evaluated the effects of sleep deprivation on locomotor activity and genetic damage in the brains of rats treated with saline or pilocarpine-induced status epilepticus (SE)." | 7.78 | Behavioral and genetic effects promoted by sleep deprivation in rats submitted to pilocarpine-induced status epilepticus. ( Alvarenga, TA; Andersen, ML; Cavalheiro, EA; Hirotsu, C; Le Sueur-Maluf, L; Matos, G; Noguti, J; Ribeiro, DA; Scorza, FA; Tufik, S, 2012) |
| "5-2 fold increase in EAAT2 protein levels as compared to their non-transgenic counterparts, were tested in a pilocarpine-induced status epilepticus (SE) model." | 7.78 | Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus. ( Kong, Q; Lin, CL; Lin, Y; Schulte, D; Stouffer, N; Takahashi, K, 2012) |
| " In the present work, we investigated whether pilocarpine-induced status epilepticus (SE) would alter Homer1a and mGluR5 expression in hippocampus." | 7.78 | Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression. ( Blanco, MM; Cavarsan, CF; Mello, LE; Morais, RL; Motta, FL; Tescarollo, F; Tesone-Coelho, C, 2012) |
| " The pilocarpine model in rodents reproduces the main features of mesial temporal lobe epilepsy related to hippocampus sclerosis (MTLE-HS) in humans." | 7.78 | Time-dependent modulation of mitogen activated protein kinases and AKT in rat hippocampus and cortex in the pilocarpine model of epilepsy. ( de Cordova, FM; de Mello, N; Leal, RB; Lopes, MW; Nunes, JC; Soares, FM; Walz, R, 2012) |
| " Pilocarpine-induced status epilepticus animal model was taken as our researching material." | 7.78 | Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. ( Chen, IC; Jaw, T; Lee, CY; Liou, HH; Tseng, HC, 2012) |
| " Here, we examined the anti-epileptogenic effect and possible mechanisms of aspirin, a non-selective Cyclooxygenase (COX) inhibitor, in a rat model of lithium-pilocarpine-induced status epilepticus (SE)." | 7.78 | Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats. ( Cui, XL; Jiang, W; Li, XW; Ma, L; Wang, Y; Wei, D; Yang, F, 2012) |
| "Status epilepticus (SE), a pro-epileptogenic brain insult in rodent models of temporal lobe epilepsy, is successfully induced by pilocarpine in some, but not all, rats." | 7.78 | Hippocampal desynchronization of functional connectivity prior to the onset of status epilepticus in pilocarpine-treated rats. ( Chen, MT; Hung, CP; Lin, YY; Shih, YH; Wang, CH, 2012) |
| " During and after pilocarpine induced status epilepticus (SE), a down-regulated expression of CCL28 in hippocampal interneurons in the CA1 area and in the hilus of the dentate gyrus was demonstrated." | 7.78 | CCL28 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus. ( Cao, X; Liu, JX; Liu, Y; Tang, FR, 2012) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 7.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| "The expression pattern of a global set of Hsps in the adult rat cerebral cortex was examined during the first week following pilocarpine-induced status epilepticus (SE)." | 7.77 | Induction of heat shock proteins in the adult rat cerebral cortex following pilocarpine-induced status epilepticus. ( Brown, IR; Lively, S, 2011) |
| "The aims of this study were to characterize the spatial distribution of neurodegeneration after status epilepticus (SE) induced by either systemic (S) or intrahippocampal (H) injection of pilocarpine (PILO), two models of temporal lobe epilepsy (TLE), using FluoroJade (FJ) histochemistry, and to evaluate the kinetics of FJ staining in the H-PILO model." | 7.77 | Comparative neuroanatomical and temporal characterization of FluoroJade-positive neurodegeneration after status epilepticus induced by systemic and intrahippocampal pilocarpine in Wistar rats. ( Castro, OW; Fernandes, A; Furtado, MA; Garcia-Cairasco, N; Pajolla, GP; Tilelli, CQ, 2011) |
| " Therefore, the present study investigated the temporal pattern of KLF6 expression in the mouse hippocampus and identified cell types expressing KLF6 after pilocarpine-induced status epilepticus (SE)." | 7.77 | Upregulation of Krüppel-like factor 6 in the mouse hippocampus after pilocarpine-induced status epilepticus. ( Cho, KO; Jeong, KH; Kim, SY; Lee, KE, 2011) |
| "We investigated the protein expression of different protein kinase C (PKC) isoforms (PKC-alpha, PKC-beta1, PKC-beta2, PKC-gamma, PKC-delta, PKC-epsilon, PKC-eta and PKC-zeta) in the hippocampus of normal control mice and progressive changes in PKC isoforms expression during and after pilocarpine induced status epilepticus (PISE)." | 7.77 | Pilocarpine-induced status epilepticus alters hippocampal PKC expression in mice. ( Liu, JX; Liu, Y; Tang, FR, 2011) |
| "The main purposes of this study were (1) to describe the whole course of status epilepticus induced by a low dose lithium-pilocarpine model in rats, including depth-EEG from the hippocampus, ECoG from cortex and gross behaviors, and (2) to investigate the possible changes of the intrinsic neural network in the hippocampus during the status epilepticus by model simulation." | 7.77 | Description and computational modeling of the whole course of status epilepticus induced by low dose lithium-pilocarpine in rats. ( Chiang, CC; Ju, MS; Lin, CC, 2011) |
| " In this study we aimed to characterize the anticonvulsive activity of ghrelin and other growth hormone secretagogue receptor 1a (GHSR(1a)) ligands in rats exposed to status epilepticus induced by pilocarpine or kainate." | 7.77 | Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus. ( Biagini, G; Bresciani, E; Coco, S; Gualtieri, F; Locatelli, V; Marinelli, C; Torsello, A; Vezzali, R, 2011) |
| "CFV, Fluoro Jade B and c-Fos staining were done at multiple time points after pilocarpine induced status epilepticus." | 7.77 | Neuron activation, degeneration and death in the hippocampus of mice after pilocarpine induced status epilepticus. ( Liu, J; Liu, Y; Tang, F, 2011) |
| "Status epilepticus was induced in the rats by administration of pilocarpine 350 mg/kg i." | 7.77 | Piperine protects epilepsy associated depression: a study on role of monoamines. ( Nayak, S; Pal, A; Sahu, PK; Swain, T, 2011) |
| " A significant loss of total dorsal subicular neurons, particularly calbindin, parvalbumin (PV) and immunopositive interneurons, was found at 2 months after pilocarpine-induced status epilepticus (SE)." | 7.76 | Morpho-physiologic characteristics of dorsal subicular network in mice after pilocarpine-induced status epilepticus. ( Bragin, A; Engel, J; He, DF; Ma, DL; Tang, FR; Tang, YC, 2010) |
| "Pilocarpine (PC), a muscarinic receptor agonist, is used for the induction of experimental models of status epilepticus (SE) for studying the type of seizure-induced brain injury and other neuropathophysiological mechanisms of related disorder." | 7.76 | The effects of pilocarpine-induced status epilepticus on oxidative stress/damage in developing animals. ( Chang, CN; Chang, SJ; Tsai, HL, 2010) |
| "Chronic epilepsy was elicited after status epilepticus (SE) induced by lithium-pilocarpine in adult Wistar rats." | 7.76 | Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine. ( Guo, Y; Jiang, L, 2010) |
| " We studied the buspirone effects on oxidative stress in rat hippocampus after seizures and status epilepticus (SE) induced by pilocarpine." | 7.76 | Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone. ( de Freitas, RL; de Freitas, RM; de Souza, GF; Saldanha, GB; Santos, IM; Tomé, Ada R, 2010) |
| "2 at acute and chronic stages during and after pilocarpine-induced status epilepticus (PISE), in order to find out the roles it may play in epileptogenesis." | 7.76 | Nuclear localization of Ca(v)2.2 and its distribution in the mouse central nervous system, and changes in the hippocampus during and after pilocarpine-induced status epilepticus. ( Hu, HT; Long, L; Soong, TW; Tang, FR; Tang, YC; Wang, J; Xu, JH, 2010) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 7.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " We induced status epilepticus (SE) with pilocarpine in adult rats, and investigated endothelial cell proliferation (BrdU and rat endothelial cell antigen-1 (RECA-1) double-labeling), vessel length (unbiased stereology), thrombocyte aggregation (thrombocyte immunostaining), neurodegeneration (Nissl staining), neurogenesis (doublecortin (DCX) immunohistochemistry), and mossy fiber sprouting (Timm staining) in the hippocampus at different time points post-SE." | 7.76 | Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. ( Gröhn, O; Hayward, N; Ndode-Ekane, XE; Pitkänen, A, 2010) |
| "In this study we investigated the effectiveness of two antiepileptic drugs: riluzole and topiramate against pilocarpine-induced seizures, which are considered to be a model of intractable epilepsy commonly used to investigate the antiepileptic effect of drugs and mechanisms of epileptogenesis." | 7.76 | Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats. ( Brzana, W; Czuczwar, M; Kiś, J; Nieoczym, D; Turski, WA; Wlaź, P; Zgrajka, W, 2010) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 7.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| " In focusing on the role of the DNA repair pathway, we determined the response of the mitochondrial base excision repair (mtBER) pathway in pilocarpine-induced status epilepticus (SE) in hippocampi of male Wistar rats." | 7.76 | Mitochondrial base excision repair pathway failed to respond to status epilepticus induced by pilocarpine. ( Cao, L; Chi, Z; Gao, J; Han, Y; Jiang, H; Lin, Y; Xie, N; Xu, J; Zhao, X, 2010) |
| " We investigate whether microinjections of GABAergic agonists into the AN were protective against pilocarpine-induced generalized seizures and status epilepticus (SE)." | 7.76 | Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus. ( Andrade, D; Bittencourt, S; Covolan, L; Dubiela, FP; Hamani, C; Lozano, A; Mello, LE; Queiroz, C, 2010) |
| " Pilocarpine was administered to induce status epilepticus." | 7.76 | Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus. ( Choy, M; Gadian, DG; Lythgoe, MF; Scott, RC; Thomas, DL; Wells, JA, 2010) |
| "In the present study we analyzed aquaporin-4 (AQP4) immunoreactivity in the piriform cortex (PC) and the hippocampus of pilocarpine-induced rat epilepsy model to elucidate the roles of AQP4 in brain edema following status epilepticus (SE)." | 7.76 | Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. ( Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, MJ; Ryu, HJ; Yeo, SI, 2010) |
| " Chi, Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus." | 7.75 | Participation of mu-calpain in status epilepticus-induced hippocampal injury. ( Lopez-Meraz, ML; Niquet, J, 2009) |
| " To address this issue, we examined the behavioral sequelae of repeated brief seizures evoked by electroconvulsive shock (ECS) and compared them with those resulting from prolonged status epilepticus (SE) induced with pilocarpine." | 7.75 | Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat. ( Cardoso, A; Carvalho, LS; Lukoyanov, NV; Lukoyanova, EA, 2009) |
| " We found that rats previously subjected to lithium-pilocarpine (LiPC)-induced neonatal status epilepticus (NeoSE) exhibited enhanced behavioral sensitization to methamphetamine (MA) in adolescence." | 7.75 | Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence. ( Chen, GS; Huang, LT; Huang, YN; Lin, TC; Wang, JY, 2009) |
| " Here we investigated the alterations of the two alpha-subunits SCN8A and SCN1A and their adapter ankyrin-G in the hippocampal cornu ammonis 1 (CA1) of rats after pilocarpine induced status epilepticus (PISE), compared to the sham-control group (C1) and blank-control group (C2)." | 7.75 | Long-term increasing co-localization of SCN8A and ankyrin-G in rat hippocampal cornu ammonis 1 after pilocarpine induced status epilepticus. ( Chen, L; Chen, S; Chen, Z; Dai, Q; Li, X; Yang, L; Zhou, J; Zhou, L, 2009) |
| " To determine if a single event of status epilepticus and its latent consequences can affect motor map expression, we assessed forelimb motor maps in rats using the pilocarpine model of temporal lobe epilepsy." | 7.75 | Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain. ( Flynn, C; Ozen, LJ; Teskey, GC; Vuong, J; Young, NA, 2009) |
| " Our laboratory recently characterized a novel plasticity change of the cannabinoid type 1 (CB(1)) receptor in hippocampi of epileptic rats following pilocarpine-induced status epilepticus (SE)." | 7.75 | Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Falenski, KW; Harrison, AJ; Martin, BR, 2009) |
| "Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus." | 7.75 | Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus. ( Cunha, AO; dos Santos, WF; Liberato, JL; Mortari, MR, 2009) |
| "To investigate the activation pattern of extracellular signal-regulated kinase 1/2 (ERK1/2) in the hippocampus of mice during pilocarpine-induced status epilepticus (SE) and its relationship with reactive astrogliosis." | 7.75 | ERK1/2 activation in reactive astrocytes of mice with pilocarpine-induced status epilepticus. ( Chen, YM; Li, YQ; Liu, H; Xu, J; Xu, ZC; Xue, T, 2009) |
| "Lithium-pilocarpine induced status epilepticus (LPSE) causes selective and age-dependent neuronal death, although the mechanism of maturation-related injury has not yet been clarified." | 7.75 | Differential expression of activating transcription factor-2 and c-Jun in the immature and adult rat hippocampus following lithium-pilocarpine induced status epilepticus. ( Han, SR; Kim, YI; Park, J; Park, S; Rhyu, S; Shin, C, 2009) |
| " Whole cell patch-clamp recordings were made from normotopic granule cells in hippocampal slices from control rats and from both normotopic and hilar ectopic granule cells in slices from rats subjected to pilocarpine-induced status epilepticus." | 7.75 | Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus. ( Nadler, JV; Zhan, RZ, 2009) |
| "To investigate protein and gene expressions of chemokine subtypes CCR3, CCR2A and their respective ligands macrophage inflammatory protein 1-alpha (MIP-1alpha), monocyte chemotactic protein-1 (MCP-1) in the normal mouse central nervous system (CNS) and in the hippocampus at different time points during and after pilocarpine-induced status epilepticus (PISE)." | 7.75 | CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE) . ( Hut, HT; Long, L; Tang, FR; Tang, YC; Xu, JH; Zhang, JT, 2009) |
| "Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy." | 7.75 | Does pilocarpine-induced epilepsy in adult rats require status epilepticus? ( Bramanti, P; Chakir, A; Fabene, PF; Marzola, P; Navarro Mora, G; Nicolato, E; Osculati, F; Sbarbati, A, 2009) |
| " The main purpose of this study was to determine whether other ketones, 2-butanone (methyl ethyl ketone: MEK) and 3-pentanone (diethyl ketone: DEK), also show anticonvulsive effects in lithium-pilocarpine (Li-pilocarpine)-induced status epilepticus (SE) in rats." | 7.75 | Methyl ethyl ketone blocks status epilepticus induced by lithium-pilocarpine in rats. ( Abe, K; Gee, A; Hasebe, N; Hosoi, R; Inoue, O; Sugiyama, E; Tsuchiya, N; Yamaguchi, M, 2009) |
| " To determine if there is a window of vulnerability in the developing rat, post-natal day 19 animals were subjected to a severe lateral fluid percussion injury followed by pilocarpine (Pc)-induced status epilepticus at 1, 6 or 24 h post TBI." | 7.75 | Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. ( Auvin, S; Giza, CC; Gurkoff, GG; Hovda, DA; Sankar, R; Shin, D, 2009) |
| " The effect of PDTC on status epilepticus-associated cell loss in the hippocampus and piriform cortex was evaluated in the rat fractionated pilocarpine model." | 7.75 | Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model. ( Fuest, C; Nickel, A; Pekcec, A; Potschka, H; Soerensen, J, 2009) |
| " In this work CCR2 and CCL2 expression were examined following status epilepticus (SE) induced by pilocarpine injection." | 7.75 | Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus. ( Arisi, GM; Foresti, ML; Katki, K; Montañez, A; Sanchez, RM; Shapiro, LA, 2009) |
| " In this study, we aimed to investigate the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus (PISE) and their relationship with epileptogenesis." | 7.74 | Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE). ( Chen, S; Chen, Z; Li, X; Zhou, J; Zhou, L; Zhu, F, 2008) |
| " Male Wistar rats were subjected to LiCl and pilocarpine status epilepticus (SE)." | 7.74 | Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. ( Baldwin, RA; Caplan, R; Mazarati, A; Sankar, R; Shin, D; Siddarth, P, 2008) |
| " We studied the activity of caspase-1, -3 and -8 in the hippocampus of rats exhibiting status epilepticus induced by pilocarpine." | 7.74 | Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus. ( Cavalheiro, EA; Cunha, RL; Dona, F; Fernandes, MJ; Juliano, L; Persike, DS; Rosim, FE; Silva, IR; Vignoli, T, 2008) |
| " Here, we investigated seizure-induced changes in mGlu2 and mGlu3 mRNA following pilocarpine-inducted status epilepticus (SE) and subsequent epileptogenesis." | 7.74 | Differential changes in mGlu2 and mGlu3 gene expression following pilocarpine-induced status epilepticus: a comparative real-time PCR analysis. ( Arshadmansab, MF; Ermolinsky, B; Garrido-Sanabria, ER; Pacheco Otalora, LF; Zarei, MM, 2008) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 7.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| "In the present study, we performed an analysis of tandem of P domains in a weak inwardly rectifying K+ channel (TWIK)-related acid-sensitive K+ (TASK)-1 channel immunoreactivity in the rat hippocampal complex following pilocarpine-induced status epilepticus (SE)." | 7.74 | Region-specific alterations in astroglial TWIK-related acid-sensitive K+-1 channel immunoreactivity in the rat hippocampal complex following pilocarpine-induced status epilepticus. ( Choi, SY; Kang, TC; Kim, JE; Kwak, SE, 2008) |
| " In the present study the effects of chronic treatment with levetiracetam were assessed in rats that sustained pilocarpine-induced status epilepticus (SE)." | 7.74 | Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats. ( Kaminski, RM; Klitgaard, H; Margineanu, DG; Matagne, A, 2008) |
| " In the present study in mGluR5 wild-type (mGluR5+/+) mice, we showed induced PKCbeta2 or PKCgamma expression at the border between the stratum oriens and alveus (O/A border) at 2h during pilocarpine induced status epilepticus (SE), and in the stratum pyramidale in CA1 area at 1 day after pilocarpine induced SE; at 1 day, induced expression of PLCbeta4 in the stratum pyramidale of CA1 area was observed." | 7.74 | mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice. ( Liu, JX; Liu, Y; Tang, FR; Tang, YC, 2008) |
| "Pilocarpine-induced status epilepticus (SE) mimics many features of temporal lobe epilepsy and is a useful model to study neural changes that result from prolonged seizure activity." | 7.74 | Extracellular matrix protein SC1/hevin in the hippocampus following pilocarpine-induced status epilepticus. ( Brown, IR; Lively, S, 2008) |
| "Recently we reported that astroglial loss and subsequent gliogenesis in the dentate gyrus play a role in epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 7.74 | Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus. ( Choi, KC; Choi, SY; Kang, TC; Kim, DS; Kim, DW; Kim, JE; Kwak, SE; Kwon, OS, 2008) |
| "2 channel and of its major modulator, voltage-dependent potassium channel-interacting protein (KChIP1), is altered following lithium-pilocarpine induced status epilepticus (SE) and the chronic-epilepsy phase in the rat model." | 7.74 | Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus. ( Cong, WD; Deng, WY; Liao, WP; Long, YS; Luo, AH; Su, T; Sun, WW, 2008) |
| "The COX-2 inhibitor celecoxib decreased neuronal excitability and prevented epileptogenesis in pilocarpine-induced status epilepticus rats." | 7.74 | Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats. ( Lei, GF; Liu, CX; Sun, RP; Yang, L; Zhang, HJ, 2008) |
| " We have shown recently that topiramate (TPM) dose-dependently protects hippocampal CA1 and CA3 neurons during initial status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibition of mitochondrial transition pore opening." | 7.74 | Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. ( Elger, CE; Frisch, C; Helmstaedter, C; Kudin, AP; Kunz, WS, 2007) |
| "The present study was designed to examine whether neuroprotective agents, FK506 or cyclosporin A (CsA), applied to rats undergoing pilocarpine-induced seizures can minimize further development of the status epilepticus." | 7.74 | Neuroprotectants FK-506 and cyclosporin A ameliorate the course of pilocarpine-induced seizures. ( Ciarach, M; Setkowicz, Z, 2007) |
| " Here, we measured the response of hippocampal Epo system components (Epo, Epo-R and betac) during neurodegenerative processes following pilocarpine-induced status epilepticus (SE), and examined whether recombinant human Epo (rHuEpo) could support neuronal survival." | 7.74 | Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus. ( Bezin, L; Georges, B; Laglaine, A; Morales, A; Moulin, C; Nadam, J; Navarro, F; Pequignot, JM; Ryvlin, P; Sanchez, P, 2007) |
| " During and after pilocarpine-induced status epilepticus, progressive changes of each of CCR7, CCR8, CCR9 and CCR10 proteins occurred in different patterns at various time points." | 7.74 | CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus. ( Cao, X; Liu, JX; Liu, Y; Tang, FR; Tang, YC, 2007) |
| "The effects of repetitive pilocarpine-induced status epilepticus (SE) in the hippocampal Na(+)/K(+)ATPase activity were studied in developing rat." | 7.74 | The Na+/K+ATPase activity is increased in the hippocampus after multiple status epilepticus induced by pilocarpine in developing rats. ( Arida, RM; da Silva Fernandes, MJ; Mara de Oliveira, D; Reime Kinjo, E, 2007) |
| " Neurochemical studies have proposed a role for catalase in brain mechanisms responsible by development to status epilepticus (SE) induced by pilocarpine." | 7.74 | Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats. ( Barbosa, CO; Barros, DO; Freitas, RL; Freitas, RM; Maia, FD; Oliveira, AA; Silva, RF; Takahashi, RN; Xavier, SM, 2007) |
| "We sought to investigate the anticonvulsive and neuroprotective effect of a selective metabotropic glutamate receptor 8 (mGluR8) agonist (S)-3,4-dicarboxyphenylglycines (S-3,4-DCPG) on pilocarpine-induced status epilepticus (PISE) and subsequent loss of hilar neurons in the dentate gyrus after systemic (intravenous) or local (intracerebroventricular) administration." | 7.74 | Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. ( Chia, SC; Jay, TM; Jiang, FL; Tang, FR; Tang, YC, 2007) |
| "Pilocarpine administration to rats results in status epilepticus (SE) and after a latency period to the occurrence of spontaneous seizures." | 7.74 | Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat. ( Goffin, K; Nissinen, J; Pitkänen, A; Van Laere, K, 2007) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| " Antioxidant properties have been showed in seizures and status epilepticus (SE) induced by pilocarpine in adult rats." | 7.74 | Vitamin C antioxidant effects in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpine. ( Barbosa, CO; Barros, DO; Freitas, RM; Oliveira, AA; Silva, RF; Xavier, SM, 2007) |
| "The aim of this pilot study was to investigate the antiepileptic effects of a novel noninvasive stimulation technique, transcutaneous electrical stimulation (TcES) via scalp concentric ring electrodes, on pilocarpine-induced status epilepticus (SE) in rats." | 7.74 | Effects of noninvasive transcutaneous electrical stimulation via concentric ring electrodes on pilocarpine-induced status epilepticus in rats. ( Besio, WG; Cole, AJ; Koka, K, 2007) |
| "By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200mg/kg), SIB1893 (from 25 to 100mg/kg), MPEP (from 25 to 100mg/kg) injected at 1 or 2h during PISE were ineffective in controlling status epilepticus (SE)." | 7.74 | Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus. ( Chen, PM; Lee, WL; Tang, FR; Tang, YC; Tsai, MC, 2007) |
| " To study developmental changes of this role LiCl/pilocarpine status epilepticus (SE) was induced in P12, P25 and/or adult rats." | 7.74 | Effects of LiCl/pilocarpine-induced status epilepticus on rat brain mu and benzodiazepine receptor binding: regional and ontogenetic studies. ( Kubová, H; Mares, P; Rocha, L; Suchomelová, L, 2007) |
| "To investigate the effects of olomoucine, a cyclin dependent protein kinase (CDK) inhibitor, on the neuronal apoptosis after status epilepticus (SE)." | 7.74 | [Effects of cyclin dependent protein kinase inhibitor olomoucine on the neuronal apoptosis after status epilepticus: experiment with rats]. ( Chen, HX; Du, XP; Sun, MZ; Tian, DS; Wang, W; Xie, MJ; Yu, ZY, 2007) |
| " In this study, we assessed changes in vascular structure, gene expression, and the time course of neuronal degeneration in the cerebral cortex during the acute period after onset of pilocarpine-induced status epilepticus (SE)." | 7.74 | Pilocarpine-induced status epilepticus in rats involves ischemic and excitotoxic mechanisms. ( Benati, D; Bernardi, P; Fabene, PF; Farace, P; Galiè, M; Marzola, P; Merigo, F; Nicolato, E; Sbarbati, A, 2007) |
| "The anticonvulsant effects of AN stimulation against pilocarpine-induced seizures were mainly determined by the current and not the frequency of stimulation." | 7.74 | Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus. ( Andrade, DM; Chiang, J; del Campo, M; Hamani, C; Hodaie, M; Lozano, AM; Mello, LE; Mirski, M; Sherman, D, 2008) |
| "This study investigated putative correlations among behavioral changes and: (1) neuronal loss, (2) hippocampal mossy fiber sprouting, and (3) reactive astrogliosis in adult rats submitted to early-life LiCl-pilocarpine-induced status epilepticus (SE)." | 7.74 | Effects of early-life LiCl-pilocarpine-induced status epilepticus on memory and anxiety in adult rats are associated with mossy fiber sprouting and elevated CSF S100B protein. ( da Silva, MC; de Oliveira, DL; e Souza, TM; Fischer, A; Gonçalves, CA; Jorge, RS; Leite, M; Quillfeldt, JA; Souza, DO; Wofchuk, S, 2008) |
| "The neuroprotective effects of pentoxifylline (PTX) against lithium-pilocarpine (Li-Pc)-induced status epilepticus (SE) in young rats are described." | 7.74 | Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats. ( Ahmad, M; Deeb, SA; Moutaery, KA; Tariq, M, 2008) |
| " A correlative study between diffusion characteristics and the severity of MFS was investigated in the pilocarpine-induced status epilepticus (SE) rat model." | 7.74 | Mossy fiber sprouting in pilocarpine-induced status epilepticus rat hippocampus: a correlative study of diffusion spectrum imaging and histology. ( Chen, CC; Chen, JH; Kuo, LW; Lee, CY; Liou, HH; Tseng, WY; Wedeen, VJ, 2008) |
| " Our study showed that there was an increased CD40 expression on activated microglia in the brain injury after lithium pilocarpine-induced status epilepticus (SE) in rats." | 7.74 | Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. ( Deng, Y; Huang, Y; Li, R; Li, Y; Sun, H; Yang, J; Yu, X; Zhao, G, 2008) |
| " The rat lithium-pilocarpine model, which mimics many features of temporal lobe epilepsy, has been used to study processes leading to the development of recurrent seizures." | 7.74 | The extracellular matrix protein SC1/hevin localizes to excitatory synapses following status epilepticus in the rat lithium-pilocarpine seizure model. ( Brown, IR; Lively, S, 2008) |
| "Kainic acid was administered in repeated low doses (5 mg/kg) every hour until each Sprague-Dawley rat experienced convulsive status epilepticus for >3 h." | 7.73 | Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy. ( Chapman, PL; Dudek, FE; Ferraro, DJ; Grabenstatter, HL; Williams, PA, 2005) |
| "The role of oxidative stress in pilocarpine-induced status epilepticus was investigated by measuring lipid peroxidation level, nitrite content, GSH concentration, and superoxide dismutase and catalase activities in the hippocampus of Wistar rats." | 7.73 | Oxidative stress in the hippocampus after pilocarpine-induced status epilepticus in Wistar rats. ( Fonteles, MM; Freitas, RM; Souza, FC; Vasconcelos, SM; Viana, GS, 2005) |
| "Multiple episodes of pilocarpine-induced status epilepticus (SE) in developing rats (P7-P9) lead to progressive epileptiform activity and severe cognitive impairment in adulthood." | 7.73 | Neocortical and hippocampal changes after multiple pilocarpine-induced status epilepticus in rats. ( Cavalheiro, EA; Cipelletti, B; Frassoni, C; Regondi, MC; Silva, AV; Spreafico, R, 2005) |
| "The status epilepticus (SE) induced in rats by lithium-pilocarpine (Li-pilo) shares many common features with soman-induced SE including extensive limbic neuropathology." | 7.73 | Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus. ( Griffith, JW; Peterson, SL; Purvis, RS, 2005) |
| "Significant reduction in glutamate receptor 1 (GluR1)- and GluR2/3-immunopositive neurons was demonstrated in the hilus of the dentate gyrus in mice killed on days 1, 7 and 60 after pilocarpine-induced status epilepticus (PISE)." | 7.73 | Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus. ( Chen, PM; Chia, SC; Gao, H; Khanna, S; Lee, WL; Liu, CP; Tang, FR; Zhang, S, 2005) |
| " We tested this hypothesis by repeatedly assessing granule cell excitability after pilocarpine-induced status epilepticus (SE) and monitoring granule cell behavior during 235 spontaneous seizures in awake, chronically implanted rats." | 7.73 | Hippocampal granule cell activity and c-Fos expression during spontaneous seizures in awake, chronically epileptic, pilocarpine-treated rats: implications for hippocampal epileptogenesis. ( Harvey, BD; Sloviter, RS, 2005) |
| "The aim of the present study was to observe possible cortical abnormalities after repetitive pilocarpine-induced status epilepticus (SE) in rats during development." | 7.73 | Disruption of cortical development as a consequence of repetitive pilocarpine-induced status epilepticus in rats. ( Cavalheiro, EA; da Silva, AV; Regondi, MC; Spreafico, R, 2005) |
| "To test effects of paraldehyde on behavioral outcome of status epilepticus (SE) in developing rats." | 7.73 | Outcome of status epilepticus in immature rats varies according to the paraldehyde treatment. ( Kubová, H; Mares, P; Redkozubova, O; Rejchrtová, J, 2005) |
| "To explore the age character of the activity of Caspase 3 and neuron death induced by LiCl-pilocarpine status epilepticus." | 7.73 | [Age difference of the activation of apoptotic cascade reaction following LiCl-pilocarpine status epilepticus]. ( Cai, FC; Cai, XT, 2005) |
| "To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 7.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
| "To further characterize the capacity of lovastatin to prevent hippocampal neuronal loss after pilocarpine-induced status epilepticus (SE) METHOD: Adult male Wistar rats were divided into four groups: (A) control rats, received neither pilocarpine nor lovastatin (n=5); (B) control rats, received just lovastatin (n=5); (C) rats that received just pilocarpine (n=5); (D) rats that received pilocarpine and lovastatin (n=5)." | 7.73 | Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results. ( Arida, RM; Cavalheiro, EA; Colugnati, DB; Cysneiros, RM; de Albuquerque, M; Rangel, P; Scorza, CA; Scorza, FA, 2005) |
| " Biochemical studies have proposed a role for AChE in brain mechanisms responsible by development to status epilepticus (SE) induced by pilocarpine." | 7.73 | Acetylcholinesterase activities in hippocampus, frontal cortex and striatum of Wistar rats after pilocarpine-induced status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Viana, GS, 2006) |
| "The administration of lithium followed by pilocarpine induces status epilepticus (SE) that produces neurodegeneration and the subsequent development of spontaneous recurrent seizures." | 7.73 | Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. ( Dykstra, CM; Gurd, JW; Huo, JZ, 2006) |
| " Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE)." | 7.73 | Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus. ( Borges, K; Dingledine, R; Irier, H; McDermott, D; Smith, Y, 2006) |
| " In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2h during pilocarpine induced status epilepticus, and never recovered." | 7.73 | Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. ( Burgunder, JM; Chang, ML; Chia, SC; Ma, DL; Probst, A; Tang, FR; Tang, YC, 2006) |
| "We developed a rat pilocarpine seizure/status epilepticus (SE) model, which closely resembles 1." | 7.73 | Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure. ( Gordon, RK; Nambiar, MP; Ratcliffe, RH; Rezk, PE; Steele, KE; Tetz, LM, 2006) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 7.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.73 | Effect of gabaergic, glutamatergic, antipsychotic and antidepressant drugs on pilocarpine-induced seizures and status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Viana, GS, 2006) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.73 | Pharmacological studies of the opioids, mood stabilizer and dopaminergic drugs on pilocarpine-induced seizures and status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Vasconcelos, SM; Viana, GS, 2006) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 7.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| " Hippocampal neurogenesis may be a critical step in the development of MFS, given that it is enhanced by at least 2-fold in the aftermath of pilocarpine-induced status epilepticus." | 7.72 | Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanism. ( Jacobs, BL; Radley, JJ, 2003) |
| "Distribution of LiCl/pilocarpine status epilepticus-induced neuronal damage was studied in the piriform cortex and in adjoining structures in 12-day-old, 25-day-old and adult rats." | 7.72 | Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent. ( Druga, R; Haugvicová, R; Kubová, H; Suchomelová, L, 2003) |
| "We applied nonlinear analysis to the results of electroencephalography (EEG) in a pilocarpine-induced status epilepticus (SE) model to characterize nonlinear dynamics according to SE phase." | 7.72 | Nonlinear dynamic characteristics of electroencephalography in a high-dose pilocarpine-induced status epilepticus model. ( Jung, KY; Kim, DW; Kim, JM, 2003) |
| " Here, we investigated the effects of antazoline on NMDA toxicity and current in rat hippocampal neuronal cultures, and on an in vivo model of status epilepticus." | 7.72 | Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus. ( Bockaert, J; Lafon-Cazal, M; Lerner-Natoli, M; Milhaud, D; Rondouin, G, 2003) |
| "High doses of the muscarinic cholinergic agonist, pilocarpine, result in behavioural changes, seizures and status epilepticus in rats." | 7.72 | [Acute alterations of neurotransmitters levels in striatum of young rat after pilocarpine-induced status epilepticus]. ( de Freitas, RM; de Sousa, FC; Fonteles, MM; Vasconcelos, SM; Viana, GS, 2003) |
| "Administration of pilocarpine causes epilepsy in rats if status epilepticus (SE) is induced at an early age." | 7.72 | Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life. ( Cavalheiro, EA; Ferreira, BL; Timo-Iaria, C; Valle, AC, 2003) |
| " Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE)." | 7.72 | Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus. ( Ballester, G; Bonilha, SM; Ewerton, FI; Hamani, C; Lozano, AM; Mello, LE, 2004) |
| "In this work, we show extensive phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2alpha) occurring in the brain of mice subjected to 30 min of status epilepticus induced by pilocarpine." | 7.72 | Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice. ( Avedissian, M; Carnevalli, LS; Castilho, BA; Jaqueta, CB; Longo, BM; Mello, LE; Pereira, CM, 2004) |
| "At 4 h during pilocarpine-induced status epilepticus (DPISE) in rat, protein kinase C (PKC)beta1, PKCbeta2, and PKCgamma were induced at the border between the stratum oriens and alveus (O/A border) of CA1 in the hippocampus." | 7.72 | Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus. ( Chen, Y; Chia, SC; Gao, H; Lee, WL; Loh, YT; Tang, FR, 2004) |
| " Experimental status epilepticus was induced with pilocarpine, and Ara-C or vehicle alone was infused continuously with an osmotic minipump." | 7.72 | Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Chu, K; Jeong, SW; Jung, KH; Kim, JY; Kim, M; Lee, SK; Lee, ST; Roh, JK; Song, YM, 2004) |
| "The aim of the study was to investigate the lipid peroxidation levels, nitrite formation, GABAergic and glutamatergic receptor densities in the hippocampus, frontal cortex and striatum of Wistar rats after seizures and status epilepticus (SE) induced by pilocarpine." | 7.72 | Pilocarpine-induced status epilepticus in rats: lipid peroxidation level, nitrite formation, GABAergic and glutamatergic receptor alterations in the hippocampus, striatum and frontal cortex. ( Fonteles, MM; Freitas, RM; Sousa, FC; Vasconcelos, SM; Viana, GS, 2004) |
| "The mechanism underlying the vulnerability of the brain to status epilepticus (SE) induced by pilocarpine remains unknown." | 7.72 | Catalase activity in cerebellum, hippocampus, frontal cortex and striatum after status epilepticus induced by pilocarpine in Wistar rats. ( Fonteles, MM; Freitas, RM; Nascimento, VS; Sousa, FC; Vasconcelos, SM; Viana, GS, 2004) |
| "The administration of pilocarpine (PILO) is widely recognized as resulting in an experimental model of temporal lobe epilepsy; it is characterized by induction of status epilepticus (SE) and spontaneous recurrent seizures after a latent period." | 7.72 | Neuroethological study of status epilepticus induced by systemic pilocarpine in Wistar audiogenic rats (WAR strain). ( Furtado, Mde A; Garcia-Cairasco, N; Oliveira, JA; Rossetti, F, 2004) |
| "The status epilepticus (SE) induced in rats by lithium-pilocarpine (Li-pilo) shares many common features with soman-induced SE including a glutamatergic phase that is inhibited by NMDA antagonists." | 7.72 | Differential neuroprotective effects of the NMDA receptor-associated glycine site partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine in lithium-pilocarpine status epilepticus. ( Griffith, JW; Peterson, SL; Purvis, RS, 2004) |
| "Pilocarpine-induced status epilepticus (SE) is an useful model to study the involvement of neurotransmitter systems as epileptogenesis modulators." | 7.72 | Monoamine levels after pilocarpine-induced status epilepticus in hippocampus and frontal cortex of Wistar rats. ( Fonteles, MM; Freitas, RM; Souza, FC; Vasconcelos, SM; Viana, GS, 2004) |
| "We studied the effects of TPM on mitochondrial function in the pilocarpine rat model of chronic epilepsy and in isolated mitochondria from rat brain." | 7.72 | The mechanism of neuroprotection by topiramate in an animal model of epilepsy. ( Debska-Vielhaber, G; Elger, CE; Kudin, AP; Kunz, WS; Vielhaber, S, 2004) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 7.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "This study characterized the electrophysiological and neuropathological changes in rat brains caused by pilocarpine (PILO)-induced status epilepticus (SE) of different duration." | 7.71 | Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations. ( Klitgaard, H; Margineanu, DG; Matagne, A; Vanneste-Goemaere, J, 2002) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 7.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| "The aim of the study was to detect by texture analysis non easily visible anomalies of magnetic resonance (MR) images of piriform and entorhinal cortices relevant to the lithium-pilocarpine (Li-Pilo) model of temporal lobe epilepsy in rats." | 7.71 | Detection of late epilepsy by the texture analysis of MR brain images in the lithium-pilocarpine rat model. ( Chambron, J; Mauss, Y; Namer, IJ; Roch, C; Yu, O, 2002) |
| "The expression of metabotropic glutamate receptor 8 (mGluR8) was studied in the rat hippocampus after pilocarpine-induced status epilepticus (APISE) by light immunohistochemistry and immunoelectron microscopy." | 7.71 | Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus. ( Lee, WL; Ling, EA; Sim, MK; Tang, FR; Yang, J, 2001) |
| " Therefore, intracellular recording and intracellular dye injection were used to characterize hilar cells in hippocampal slices from pilocarpine-treated rats that had status epilepticus and recurrent seizures ('epileptic' rats)." | 7.71 | Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells. ( Goodman, JH; Scharfman, HE; Smith, KL; Sollas, AL, 2001) |
| "The expression of metabotropic glutamate receptor 1alpha was studied in the rat hippocampus after pilocarpine-induced status epilepticus by Western blot and immunocytochemistry at both light and electron microscopic levels." | 7.71 | Expression of metabotropic glutamate receptor 1alpha in the hippocampus of rat pilocarpine model of status epilepticus. ( Lee, WL; Ling, EA; Sim, MK; Tang, FR; Yang, J, 2001) |
| "The aim of this study was to determine the effect of the duration of pilocarpine-induced status epilepticus (SE) on subsequent cognitive function in rats." | 7.71 | Effect of duration of pilocarpine-induced status epilepticus on subsequent cognitive function in rats. ( Balakrishnan, S; Nidhi, G; Pandhi, P, 2001) |
| "Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE)." | 7.71 | Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss. ( Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL, 2001) |
| " Lithium-pilocarpine-induced status epilepticus is associated with extended damage in adult rats, mostly in the forebrain limbic areas and thalamus, whereas damage was moderate in 21-day-old rats (P21) or absent in P10 rats." | 7.71 | Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage. ( Ferrandon, A; Nehlig, A; Pereira de Vasconcelos, A, 2002) |
| " This study investigated p53 expression in the immature and adult rat brain following status epilepticus induced by the administration of lithium-pilocarpine (LPSE)." | 7.71 | Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus. ( Liu, H; Sankar, R; Schreiber, SS; Shin, D; Sun, N; Tan, Z; Wasterlain, CG, 2002) |
| " Recent studies have demonstrated an age-dependent induction of both p53 mRNA and protein in the rat brain following lithium-pilocarpine-mediated status epilepticus (LPSE)." | 7.71 | Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus. ( Liu, H; Sankar, R; Schreiber, SS; Shin, D; Tan, Z; Tu, W; Wasterlain, CG, 2002) |
| "Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain." | 7.71 | Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats. ( Cheng, SC; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, TJ; Wu, CL; Yang, SN, 2002) |
| " To address this issue further, we asked whether the new hilar granule cells were active during spontaneous limbic seizures that follow status epilepticus induced by pilocarpine injection." | 7.71 | Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus. ( Goodman, JH; Scharfman, HE; Sollas, AL, 2002) |
| " Using digital imaging and fluorescence microscopy it is possible to evaluate neuronal ethidium accumulation in specific brain regions of rats damaged in the lithium-pilocarpine model of status epilepticus." | 7.71 | Hydroethidine detection of superoxide production during the lithium-pilocarpine model of status epilepticus. ( Liu, KJ; Liu, S; Morrow, D; Peterson, SL, 2002) |
| "Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures." | 7.71 | The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures. ( Berkeley, JL; Decker, MJ; Levey, AI, 2002) |
| "In order to follow the spatial and temporal evolution of neuronal damage, cellular activation and stress responses subsequent to lithium-pilocarpine seizures of various durations in the adult rat, we analyzed the expression of Fos protein and local cerebral glucose utilization as markers of cellular activation, HSP72 immunoreactivity and acid fuchsin staining as indicators of cellular stress and injury, and Cresyl violet staining for the assessment of neuronal damage." | 7.70 | Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. ( Baram, TZ; Fernandes, MJ; Motte, J; Nehlig, A, 1998) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 7.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| "The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE)." | 7.70 | Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats. ( Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A, 1999) |
| "Changes in residual ATP concentrations were investigated following subcellular fractionation of rat brain cortex after a prolonged period of status epilepticus induced by sequential administration of lithium and pilocarpine." | 7.70 | Altered residual ATP content in rat brain cortex subcellular fractions following status epilepticus induced by lithium and pilocarpine. ( Nagy, AK; Treiman, DM; Walton, NY, 1998) |
| "Status epilepticus (SE) was induced in adult Long-Evans rats by pilocarpine (320 mg/kg, i." | 7.70 | Cognitive functions after pilocarpine-induced status epilepticus: changes during silent period precede appearance of spontaneous recurrent seizures. ( Broźek, G; Hort, J; Komárek, V; Langmeier, M; Mares, P, 1999) |
| "Functional modulation of gamma-aminobutyric acid(A) (GABA(A)) receptors by Zn(2+), pentobarbital, neuroactive steroid alphaxalone, and flunitrazepam was studied in the cerebral cortex and cerebellum of rats undergoing status epilepticus induced by pilocarpine." | 7.70 | Zinc inhibition of gamma-aminobutyric acid(A) receptor function is decreased in the cerebral cortex during pilocarpine-induced status epilepticus. ( Banerjee, PK; Olsen, RW; Snead, OC, 1999) |
| " Pilocarpine-treated rats present status epilepticus, which is followed by a seizure-free period (silent), by a period of spontaneous recurrent seizures (chronic), and the hippocampus of these animals exhibits cell loss and mossy fiber sprouting." | 7.70 | Selective alterations of glycosaminoglycans synthesis and proteoglycan expression in rat cortex and hippocampus in pilocarpine-induced epilepsy. ( Amado, D; Argañaraz, GA; Bellissimo, MI; Cavalheiro, EA; Nader, HB; Naffah-Mazzacoratti, MG; Porcionatto, MA; Scorza, FA; Silva, R, 1999) |
| "The aim of the study was to investigate the changes in biochemical mechanisms facilitating cellular damages in the lithium plus pilocarpine treatment and the resulting status epilepticus." | 7.70 | Lithium plus pilocarpine induced status epilepticus--biochemical changes. ( Eraković, V; Laginja, J; Simonić, A; Varljen, J; Zupan, G, 2000) |
| " As temporal lobe epilepsy is linked to neuronal damage in the hippocampus, we tested the effect of repeated ECS on subsequent status epilepticus (SE) induced by lithium-pilocarpine and leading to cell death and temporal epilepsy in the rat." | 7.70 | Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy. ( André, V; Ferrandon, A; Marescaux, C; Nehlig, A, 2000) |
| "Estimates of neuronal dropout for approximately 100 structures as defined by Paxinos-Watson were completed for brains of male Wistar albino rats between 1 and 50 days after status epilepticus was evoked by a single systemic injection of lithium and pilocarpine." | 7.70 | Temporal changes in neuronal dropout following inductions of lithium/pilocarpine seizures in the rat. ( Mastrosov, L; Parker, G; Peredery, O; Persinger, MA, 2000) |
| "The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats." | 7.70 | Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus. ( Güleç, G; Noyan, B, 2000) |
| " We studied the expression of hippocampal substance P in rats in using lithium-pilocarpine model of status epilepticus during development." | 7.70 | Patterns of status epilepticus-induced substance P expression during development. ( Liu, H; Mazarati, AM; Sankar, R; Shin, DH; Wasterlain, CG, 2000) |
| "We investigated the neuroprotective effect of the noncompetitive N-methyl-D-asparatate (NMDA) antagonist ketamine when administered after onset of lithium-pilocarpine-induced status epilepticus (SE)." | 7.69 | Neuroprotective effect of ketamine administered after status epilepticus onset. ( Fujikawa, DG, 1995) |
| "Status epilepticus induced by pilocarpine in rats induces massive tissue damage comprising neurons and astrocytes (incomplete infarction) in substantia nigra pars reticulata (SNR) and in basal cortical areas (BCTX)." | 7.69 | Loss of immunoreactivity for glial fibrillary acidic protein (GFAP) in astrocytes as a marker for profound tissue damage in substantia nigra and basal cortical areas after status epilepticus induced by pilocarpine in rat. ( Ingvar, M; Schmidt-Kastner, R, 1994) |
| " Using limbic motor status epilepticus induced by pilocarpine to activate neurons in motor and limbic areas, we now demonstrate GDNF mRNA signals in the striatum, hippocampus and cortex using in situ hybridisation." | 7.69 | Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats. ( Bektesh, S; Hoffer, B; Olson, L; Rosenzweig, B; Schmidt-Kastner, R; Tomac, A, 1994) |
| "The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats." | 7.69 | Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine. ( Jope, RS; Williams, MB, 1994) |
| "Pilocarpine (PILO) administered to rats acutely induces status epilepticus (acute period), which is followed by a transient seizure-free period (silent period), and finally by a chronic phase of spontaneous recurrent seizures (chronic period, SRS) that lasts for the rest of animal's life." | 7.69 | Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. ( Bellíssimo, MI; Cavalheiro, EA; Naffah-Mazzacoratti, MG, 1995) |
| "We studied the effects of status epilepticus (SE) induced by lithium chloride/pilocarpine treatment on gene expression of neurotrophins of the nerve growth factor (NGF) family and of their high-affinity receptors of the tyrosine protein kinase (trk) family in the forebrain." | 7.69 | Change in neurotrophins and their receptor mRNAs in the rat forebrain after status epilepticus induced by pilocarpine. ( Belluardo, N; Bindoni, M; Jiang, XH; Mudò, G; Timmusk, T, 1996) |
| ") or intrahippocampal injection of carbachol (100 micrograms/1 microliters) induced limbic motor seizures in rats, characterized by head weaving and paw treading, rearing and falling, and forepaw myoclonus, developing into status epilepticus." | 7.69 | Regional changes in brain dopamine utilization during status epilepticus in the rat induced by systemic pilocarpine and intrahippocampal carbachol. ( Alam, AM; Starr, MS, 1996) |
| " In this study, a high dose of pilocarpine (300 mg/kg) was used to induce long-lasting, limbic motor status epilepticus and a selective pattern of brain damage." | 7.69 | Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus. ( Humpel, C; Olson, L; Schmidt-Kastner, R; Wetmore, C, 1996) |
| "Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice." | 7.69 | The pilocarpine model of epilepsy in mice. ( Cavalheiro, EA; Priel, MR; Santos, NF, 1996) |
| "Acute seizures and status epilepticus induced by pilocarpine lead to the expression of Fos-like immunoreactivity in several specific brain areas in a manner similar to that of other models of limbic seizures." | 7.69 | Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats. ( Cavalheiro, EA; Finch, DM; Kohman, CM; Mello, LE; Tan, AM, 1996) |
| " To study the age-related susceptibility to the development of chronic epilepsy we used the pilocarpine model of epilepsy (PME)." | 7.69 | Developmental aspects of the pilocarpine model of epilepsy. ( Cavalheiro, EA; dos Santos, NF; Priel, MR, 1996) |
| "Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice." | 7.69 | Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. ( Cohen, AL; Karp, E; Kokate, TG; Rogawski, MA, 1996) |
| "Since its original description over 10 years ago, the pilocarpine model of status epilepticus (SE) has gained considerable attention." | 7.69 | Status epilepticus induced by pilocarpine and picrotoxin. ( Hamani, C; Mello, LE, 1997) |
| "Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats." | 7.69 | Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. ( George, B; Kulkarni, SK, 1997) |
| "The present work studied the effect of a calcium channel blocker (nimodipine) on rat behavioural changes and brain lesions observed after seizures induced by high doses of pilocarpine (400 mg/kg, s." | 7.69 | Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats. ( Aguiar, LM; de Bruin, VM; de Pinho, RS; de Sousa, FC; Marinho, MM; Viana, GS, 1997) |
| " after they had been assigned to one of 8 groups in a 3-way analysis of variance design that involved (1) induction of limbic seizures by a systemic injection of lithium/pilocarpine, (2) physical restraint, and (3) administration of acepromazine." | 7.68 | Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury. ( Bureau, YR; Persinger, MA, 1993) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 7.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "Lithium is known to potentiate the ability of pilocarpine to induce status epilepticus in rats." | 7.68 | Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats. ( Baram, TZ; Hirsch, E; Snead, OC, 1992) |
| " The object of this study was to determine the effect of SCC on behavioral and EEG symptomatology in the lithium-pilocarpine model of seizures and status epilepticus in the rat." | 7.68 | Corpus callosotomy in the lithium-pilocarpine model of seizures and status epilepticus. ( Gilles, F; Hirsch, E; Snead, OC; Vergnes, M, 1992) |
| "The specific binding of [3H]hemicholinium-3 ([3H]HCh-3) and high-affinity [3H]choline uptake were measured in rats with status epilepticus induced by lithium and pilocarpine." | 7.68 | [3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine. ( Coyle, JT; Saltarelli, MD; Yamada, K, 1991) |
| "Amino acid concentrations were measured in specific structures from the brains of rats decapitated before and during the course of status epilepticus induced by lithium and pilocarpine, with the stages of status defined by the electroencephalographic (EEG) pattern displayed." | 7.68 | Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine. ( Gunawan, S; Treiman, DM; Walton, NY, 1990) |
| "Male Wistar rats were subjected to pilocarpine-induced status epilepticus and allowed to recover." | 7.68 | Learning impairment in chronic epileptic rats following pilocarpine-induced status epilepticus. ( Cavalheiro, EA; Leite, JP; Lemos, T; Masur, J; Nakamura, EM, 1990) |
| "We measured the effects of four weeks of dietary lithium treatment and of status epilepticus induced by administration of pilocarpine to lithium-treated rats on the concentrations of amino acids in four regions of rat brain: cerebral cortex, hippocampus, striatum, and substantia nigra." | 7.67 | Chronic lithium treatment and status epilepticus induced by lithium and pilocarpine cause selective changes of amino acid concentrations in rat brain regions. ( Ferraro, TN; Hare, TA; Jope, RS; Miller, JM, 1989) |
| "Status epilepticus was produced in rats by administering pilocarpine (30 mg/kg, s." | 7.67 | Neurochemical consequences of status epilepticus induced in rats by coadministration of lithium and pilocarpine. ( Jope, RS; Morrisett, RA, 1986) |
| "Status epilepticus (SE) was induced in rats by administration of 3 mmol/kg lithium chloride followed 24 h later by injection of 25 mg/kg pilocarpine." | 7.67 | Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. ( Treiman, DM; Walton, NY, 1988) |
| "The ability of various drugs to prevent the onset of status epilepticus induced by administration of the muscarinic agonist, pilocarpine, to lithium-pretreated rats was determined." | 7.67 | Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. ( Jope, RS; Morrisett, RA; Snead, OC, 1987) |
| "The effects of status epilepticus on the concentration, synthesis, release, and subcellular localization of acetylcholine, the concentration of choline, and the activity of acetylcholinesterase in rat brain regions were studied." | 7.67 | Acetylcholine content in rat brain is elevated by status epilepticus induced by lithium and pilocarpine. ( Jope, RS; Lally, K; Simonato, M, 1987) |
| "Subcutaneous administration of pilocarpine to rats that were pretreated with a small dose of lithium chloride results in the evolution of generalized convulsive status epilepticus." | 7.67 | Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats. ( Jope, RS; Morrisett, RA; Snead, OC, 1986) |
| "Status epilepticus is a neurological disorder that can result in various neuropathological conditions and presentations." | 7.01 | The applications of the pilocarpine animal model of status epilepticus: 40 years of progress (1983-2023). ( Che Has, AT, 2023) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 5.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Epilepsy is one of the most common neurologic diseases, and around 30% of all epilepsies, particularly the temporal lobe epilepsy (TLE), are highly refractory to current pharmacological treatments." | 5.91 | A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes. ( Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á, 2023) |
| "Acute brain inflammation after status epilepticus (SE) is involved in blood-brain barrier (BBB) dysfunction and brain edema, which cause the development of post-SE symptomatic epilepsy." | 5.72 | Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice. ( Dohgu, S; Ishihara, Y; Itoh, K; Komori, R; Matsumoto, J; Matsuo, T; Nakatani, M; Ochi, S; Takata, F; Yokota-Nakatsuma, A, 2022) |
| "However, the effect of seizures on Cx expression is controversial." | 5.72 | Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus. ( Andrioli, A; Barresi, V; Bentivoglio, M; Condorelli, DF; Di Liberto, V; Fabene, PF; Frinchi, M; Mudò, G, 2022) |
| "Rosiglitazone has recently been considered as a potential neuroprotective factor in epilepsy because of its antioxidative function." | 5.62 | Rosiglitazone Prevents Autophagy by Regulating Nrf2-Antioxidant Response Element in a Rat Model of Lithium-pilocarpine-induced Status Epilepticus. ( Chen, L; Peng, Y; Qu, Y; Wang, D; Zhu, Y, 2021) |
| "In mice that experienced seizures without status epilepticus (SE), the number of proliferating progenitors and immature neurons were significantly increased, whereas no changes were observed in RGL cells." | 5.56 | The polarity and properties of radial glia-like neural stem cells are altered by seizures with status epilepticus: Study using an improved mouse pilocarpine model of epilepsy. ( Sasaki-Takahashi, N; Seki, T; Shinohara, H; Shioda, S, 2020) |
| "Pilocarpine-treated neonatal rats showed long-term abnormal neurobehavioral parameters." | 5.51 | Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin. ( Chen, SH; Jin, MF; Li, LL; Ni, H, 2019) |
| "Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus." | 5.51 | Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. ( Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J, 2019) |
| "Ifenprodil (20 mg/kg) was administered intraperitoneally (ip) after the stimulation with 3." | 5.48 | Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats? ( Abbasova, K; Kubová, H; Mareš, P, 2018) |
| "Treatment with memantine increase latency to SE onset only in groups treated 3 h before or concomitant with pilocarpine." | 5.48 | Memantine decreases neuronal degeneration in young rats submitted to LiCl-pilocarpine-induced status epilepticus. ( de Oliveira, DL; Dos Santos, TG; Kalinine, E; Mussulini, BHM; Portela, LVC; Zenki, KC; Zimmer, ER, 2018) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 5.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| " Therefore, in the present study, the neuroprotective effects and mechanisms of vit-D alone or in combination with lamotrigine have been evaluated in the lithium-pilocarpine model of SE in rats." | 5.46 | Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats. ( Abdel-Wahab, AF; Afify, MA; Al Ghamdi, SS; Bamagous, GA; ElSawy, NA; Ibrahim, IAA; Mahfoz, AM; Shahzad, N, 2017) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Since traumatic brain injury is one of the strongest determinants of epileptogenesis, the present study focuses on the question whether a moderate long-term physical training can decrease susceptibility to seizures evoked following brain damage." | 5.43 | Physical training decreases susceptibility to pilocarpine-induced seizures in the injured rat brain. ( Gzieło-Jurek, K; Janeczko, K; Kaczyńska, M; Kosonowska, E; Setkowicz, Z, 2016) |
| "The limbic seizures were classified using the Racine's scale, and the amount of wet dog shakes (WDS) was quantified before and during SE." | 5.43 | Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus. ( Cardoso-Sousa, L; Castro, OW; Costa, MA; Duzzioni, M; Garcia-Cairasco, N; Gitaí, DLG; Goulart, LR; Melo, IS; Pacheco, ALD; Pereira, UP; Sabino-Silva, R; Santos, YMO; Silva, NKGT; Tilelli, CQ, 2016) |
| "Thymoquinone (TQ) is a bioactive monomer extracted from black seed (Nigella sativa) oil, which has anti-inflammatory properties in the context of various diseases." | 5.43 | Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus. ( Chen, L; Chen, Y; Feng, Y; Li, B; Luo, Q; Shao, Y; Xie, Y, 2016) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 5.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| "Mounting evidence suggests that brain inflammation mediated by glial cells may contribute to epileptogenesis." | 5.42 | Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Gao, B; Gu, J; Mi, X; Wang, N; Wang, W; Wang, X; Zhang, Y, 2015) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 5.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| "In pilocarpine-treated chronically epileptic rats, we describe a novel mechanism that causes an increased proximal dendritic persistent Na(+) current (INaP)." | 5.42 | Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. ( Beck, H; Becker, A; Kaupp, UB; Kelly, T; Opitz, T; Otte, DM; Pitsch, J; Rennhack, A; Royeck, M; Schoch, S; Woitecki, A; Yaari, Y; Zimmer, A, 2015) |
| "Status epilepticus affected male and female rats differentially." | 5.40 | Effect of lithium-pilocarpine-induced status epilepticus on ultrasonic vocalizations in the infant rat pup. ( Beltrán-Parrazal, L; López-Meraz, ML; Manzo, J; Medel-Matus, JS; Morgado-Valle, C; Pérez-Estudillo, C, 2014) |
| "Brain edema was assessed by means of magnetic resonance imaging (T2 relaxometry) and hippocampal volumetry was used as a marker of neuronal injury." | 5.40 | Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus. ( Chun, KP; Duffy, BA; Lythgoe, MF; Ma, D; Scott, RC, 2014) |
| "Proglumide (Pgm) is a known cholecystokinin (CCK) antagonist and any changes in the level of CCK and in the number of CCK receptors has been linked with SE." | 5.40 | Ameliorating effects of proglumide on neurobehavioral and biochemical deficits in animal model of status epilepticus. ( Ahmad, M; Wadaan, MA, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 5.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| "Better treatment of status epilepticus (SE), which typically becomes refractory after about 30 min, will require new pharmacotherapies." | 5.39 | A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus. ( Bialer, M; Dudek, FE; Hen, N; Kaufmann, D; Nelson, C; Pouliot, W; Ricks, K; Roach, B; Shekh-Ahmad, T; Yagen, B, 2013) |
| "Ketamine post-SE onset treatment prevented neuronal death in all regions assessed." | 5.38 | Ketamine reduces neuronal degeneration and anxiety levels when administered during early life-induced status epilepticus in rats. ( Córdova, SD; de Oliveira, DL; Loss, CM, 2012) |
| "The effects of cathodal tDCS on convulsions and spatial memory after status epilepticus (SE) in immature animals were investigated." | 5.37 | Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats. ( Abe, T; Eshima, N; Fujiki, M; Kamida, T; Kobayashi, H; Kong, S, 2011) |
| "Status epilepticus was induced in postnatal day 20 Sprague-Dawley rat pups with the chemoconvulsant lithium-pilocarpine and brain tissue was examined with Fluoro-Jade B." | 5.37 | Lithium pilocarpine-induced status epilepticus in postnatal day 20 rats results in greater neuronal injury in ventral versus dorsal hippocampus. ( Dudek, FE; Ekstrand, JJ; Pouliot, W; Scheerlinck, P, 2011) |
| "Status epilepticus is a clinical emergency that can lead to the development of acquired epilepsy following neuronal injury." | 5.36 | Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. ( Carter, DS; DeLorenzo, RJ; Deshpande, LS; Nagarkatti, N, 2010) |
| "Edaravone (MCI-186) is a newly developed antioxidative radical scavenger for the treatment of acute cerebral infarction, exerting neuroprotective effects against ischemic insult." | 5.35 | Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus. ( Abe, T; Anan, M; Fujiki, M; Kamida, T; Kobayashi, H; Ooba, H, 2009) |
| " For this study, we used the same pilocarpine ramping-up dosing protocol and behavioral test battery than in a previous study in NMRI mice, thus allowing direct comparison between these two mouse strains." | 5.35 | Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. ( Bankstahl, M; Gröticke, I; Löscher, W; Müller, CJ, 2009) |
| "Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality." | 5.35 | Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus. ( Bracey, JM; Churn, SB; Kurz, JE; Low, B, 2009) |
| "Convulsive status epilepticus is associated with subsequent hippocampal damage and development of mesial temporal sclerosis in a subset of individuals." | 5.34 | Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. ( Bamidele, A; Begum, S; Choy, M; de Castro, SC; Gadian, DG; Greene, ND; Leung, KY; Lythgoe, MF; Scott, RC; Wait, R, 2007) |
| "The pilocarpine model of SE was characterized both behaviorally and electrographically." | 5.33 | Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat. ( Churn, SB; Holbert, WH; Kurz, JE; Lee, AT; Ryan, ML; Singleton, MW, 2005) |
| "The pilocarpine model of SE was characterized both behaviorally and electrographically." | 5.33 | Modulation of CaM kinase II activity is coincident with induction of status epilepticus in the rat pilocarpine model. ( Bracey, JM; Churn, SB; Holbert, WH; Lee, AT; Singleton, MW, 2005) |
| "Thereafter, seizures were induced by pilocarpine injections in trained and non-trained control groups." | 5.33 | Physical training decreases susceptibility to subsequent pilocarpine-induced seizures in the rat. ( Mazur, A; Setkowicz, Z, 2006) |
| "Spontaneous recurrent seizures were monitored with Racine's seizure severity scale." | 5.32 | Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. ( Chu, K; Jeon, D; Jeong, SW; Jung, KH; Kim, J; Kim, M; Kim, SU; Lee, SK; Lee, ST; Roh, JK; Shin, HS, 2004) |
| "Pilocarpine was administered systemically (380mg/kg i." | 5.31 | Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus. ( Capek, R; De Koninck, Y; Poirier, JL, 2000) |
| "Status epilepticus is associated with sustained and elevated levels of cytosolic Ca(2+)." | 5.31 | Pilocarpine-induced status epilepticus causes N-methyl-D-aspartate receptor-dependent inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake. ( Churn, SB; DeLorenzo, RJ; Kochan, LD; Parsons, JT, 2000) |
| "Status epilepticus was induced by pilocarpine injection and allowed to continue for 60 min." | 5.31 | A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus. ( Churn, SB; Delorenzo, RJ; Kurz, JE; Parsons, JT; Rana, A; Sheets, D, 2001) |
| "We examined spontaneous seizure development and correlative axon sprouting in the dentate gyrus of CD-1 and C57BL/6 mice after systemic injection of pilocarpine." | 5.31 | Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice. ( Shibley, H; Smith, BN, 2002) |
| "Behavioral seizures were characterized by sustained or recurrent bouts of clonus in all limbs." | 5.30 | Lithium-pilocarpine status epilepticus in the immature rabbit. ( Thompson, K; Wasterlain, C, 1997) |
| "The course of untreated epilepsy is not well established." | 5.30 | The course of untreated seizures in the pilocarpine model of epilepsy. ( Arida, RM; Cavalheiro, EA; Peres, CA; Scorza, FA, 1999) |
| "Dizocilpine maleate-pretreated animals responded rapidly to diazepam treatment, even after 60 min of status epilepticus." | 5.30 | N-methyl-D-aspartate receptor activation regulates refractoriness of status epilepticus to diazepam. ( DeLorenzo, RJ; Rice, AC, 1999) |
| "These seizures were followed by seemingly complete neurological recovery." | 5.29 | Long-term behavioral deficits following pilocarpine seizures in immature rats. ( Gatt, A; Holmes, GL; Liu, Z; Mikati, MA; Werner, SJ, 1994) |
| "Initially seizures are discrete, then undergo waxing-and-waning of convulsive/electroencephalographic severity." | 5.29 | Functional mapping of the early stages of status epilepticus: a 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat. ( Handforth, A; Treiman, DM, 1995) |
| " These results demonstrated that both acute and chronic administration of lithium enhance cholinergic function in vivo." | 5.27 | Status epilepticus is produced by administration of cholinergic agonists to lithium-treated rats: comparison with kainic acid. ( Jope, RS; Morrisett, RA; Snead, OC, 1987) |
| "Behaviorally, the animals showed motor seizures which varied between stages I through IV, with evidence of extensive bilateral hemispheric involvement through much of the seizure episode." | 5.27 | Status epilepticus facilitated by pilocarpine in amygdala-kindled rats. ( Buterbaugh, GG; Keyser, DO; Michelson, HB, 1986) |
| "Fundamental work on the mechanisms leading to focal epileptic discharges in mesial temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial status epilepticus (SE) is induced by kainic acid or pilocarpine." | 5.12 | The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches. ( Avoli, M; Biagini, G; de Curtis, M; Gnatkovsky, V; Lévesque, M; Pitsch, J; Wang, S, 2021) |
| "PT after SE reduces the recurrent seizures and improves the morphological, biochemical and cognitive profiles of pilocarpine epileptic models." | 4.95 | Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models. ( Chen, XL; Iqbal, M; Liu, JX; Liu, Y; Rahman, MS; Zafar, S, 2017) |
| "The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs)." | 4.85 | The pilocarpine model of epilepsy: what have we learned? ( Arida, RM; Calderazzo, L; Cavalheiro, EA; Naffah-Mazzacoratti, Mda G; Scerni, DA; Scorza, FA, 2009) |
| "Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the use of models of status epilepticus (SE), as in the case of the pilocarpine model." | 4.84 | The pilocarpine model of temporal lobe epilepsy. ( Avoli, M; Biagini, G; Curia, G; Jones, RS; Longo, D, 2008) |
| "Local or systemic administration of pilocarpine and kainate in rodents leads to a pattern of repetitive limbic seizures and status epilepticus, which can last for several hours." | 4.81 | New insights from the use of pilocarpine and kainate models. ( Cavalheiro, EA; Garcia-Cairasco, N; Leite, JP, 2002) |
| "The pilocarpine-induced (PILO) model has helped elucidate the electrophysiological and molecular aspects related to mesial temporal lobe epilepsy." | 4.31 | Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival. ( Athié, MCP; Cavalheiro, EA; Cendes, F; Conte, FF; Covolan, L; Gilioli, R; Lopes-Cendes, I; Malheiros, JM; Marchesini, RB; Matos, AHB; Pascoal, LB; Pascoal, VDB; Pereira, TC; Polli, RS; Secolin, R; Tannús, A; Vieira, AS, 2023) |
| "The blockage of transient receptor potential vanilloid 4 (TRPV4) inhibits inflammation and reduces hippocampal neuronal injury in a pilocarpine-induced mouse model of temporal lobe epilepsy." | 4.31 | Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus. ( An, D; Chen, L; Chen, X; Du, Y; Li, K; Qi, X; Sha, S; Wang, Y; Wu, C; Xu, W, 2023) |
| "The present study aims to formulate and evaluate the efficacy of chrysin-loaded nanoemulsion (CH NE) against lithium/pilocarpine-induced epilepsy in rats, as well as, elucidate its effect on main epilepsy pathogenesis cornerstones; neuronal hyperactivity, oxidative stress, and neuroinflammation." | 4.31 | Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway. ( Ahmed, N; Ahmed, Y; Alshafei, H; Alshafei, R; Ashraf, N; El-Derany, MO; Ezz, S; George, MY; Ibrahim, C; Ibrahim, SS; Khaled, G; Khaled, H; Saleh, A; Waleed, H; Zaher, M, 2023) |
| "The anticonvulsant and antioxidant effects of lamotrigine on status epilepticus (SE) are incompletely understood." | 4.31 | Anticonvulsant and antioxidant effects of lamotrigine on pilocarpine-induced status epilepticus in mice. ( Fujiki, M; Kamida, T; Momii, Y; Onishi, K; Sugita, K, 2023) |
| "Status epilepticus (SE) triggered by lithium-pilocarpine is a model of epileptogenesis widely used in rats, reproducing many of the pathological features of human temporal lobe epilepsy (TLE)." | 4.31 | The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection. ( Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MÁ, 2023) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 4.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| "The objective of this work was to evaluate the antiseizure effect of the antioxidants allopurinol (ALL) and ellagic acid during status epilepticus induced by pilocarpine (PILO)." | 4.31 | Allopurinol and ellagic acid decrease epileptiform activity and the severity of convulsive behavior in a model of status epilepticus. ( Martínez-Gallegos, S; Medina-Ceja, L; Pardo-Peña, K; Sánchez-Lira, A, 2023) |
| " In this study, we investigated the anti-inflammatory action of eugenol in an experimental epilepsy model of pilocarpine-induced status epilepticus (SE)." | 4.31 | Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus. ( Jeong, KH; Kim, CH; Kim, WJ; Park, S; Zhu, J, 2023) |
| "Untreated lithium/pilocarpine SE induced a large increase in aggressive behavior, which involved all aspects of aggression in the resident-intruder paradigm when tested 3 months after SE." | 4.31 | Interictal aggression in rats with chronic seizures after an early life episode of status epilepticus. ( Baldwin, RA; Niquet, J; Suchomelova, L; Thompson, KW; Wasterlain, CG, 2023) |
| "The authors investigated changes in vascular reactivity in rats following pilocarpine-induced status epilepticus." | 4.31 | Reduction of vascular reactivity in rat aortas following pilocarpine-induced status epilepticus. ( Cavalheiro, EA; Nunes, KZ; Scorza, FA; Vassallo, DV, 2023) |
| " Here, tau expression and phosphorylation at three canonical loci known to be hyperphosphorylated in AD (S202/T205, T181, and T231) were studied in the rat pilocarpine status epilepticus (SE) model of temporal lobe epilepsy (TLE)." | 4.31 | Progressive Dysregulation of Tau Phosphorylation in an Animal Model of Temporal Lobe Epilepsy. ( Concepcion, FA; Ekstrom, NA; Estes, OO; Khan, MN; Poolos, NP, 2023) |
| " We recently found that in the pilocarpine-induced status epilepticus (PILO-SE) mouse model of TLE there was an increase in CA2 intrinsic excitability associated with a loss of CA2 synaptic inhibition." | 4.31 | Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy. ( Barnett, A; Lisgaras, CP; Santoro, B; Scharfman, HE; Siegelbaum, SA; Whitebirch, AC, 2023) |
| " U50488, a selective KOR agonist is used to determine its effect on status epilepticus (SE), spontaneous convulsive seizures (SS) and cognitive impairment in rat lithium-pilocarpine SE model." | 4.31 | Effect of U50488, a selective kappa opioid receptor agonist and levetiracetam against lithium-pilocarpine-induced status epilepticus, spontaneous convulsive seizures and related cognitive impairment. ( Katyal, J; Kumar Gupta, Y; Kumar, H, 2023) |
| " A single, systemic dose of mefloquine administered early after pilocarpine-induced status epilepticus (SE) in rat reduced both development of SRS and behavioral co-morbidities." | 4.31 | Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus. ( Santhakumar, V; Shao, M; Yu, H; Yu, J, 2023) |
| " Using a pilocarpine-induced mice model of epilepsy, we showed that Gpc4 expression was significantly increased in the stratum granulosum of the dentate gyrus at 1 week after status epilepticus (SE)." | 4.12 | Neuronal Glypican4 promotes mossy fiber sprouting through the mTOR pathway after pilocarpine-induced status epilepticus in mice. ( Hu, HB; Ji, C; Liu, JX; Ma, KG; Ma, YB; Peng, SM; Ren, LD; Si, KW; Wu, F; Wu, XL; Xiao, XL; Yan, QS; Yang, BN; Zhou, JS, 2022) |
| "Only few studies have focus on animals that received Pilocarpine (Pilo) and did not develop behavioral status epilepticus (SE) and, whether they may become epileptic in the model's chronic phase." | 4.12 | Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. ( Amado, D; Amorim, RP; Cossa, AC; da Silva, JC; Dal Pai, J; Predebon, G; Sanabria, V; Trindade-Filho, E, 2022) |
| " We examined the contribution of surviving mossy cells to network activity in the reorganized dentate gyrus after pilocarpine-induced status epilepticus (SE)." | 4.12 | Adaptive Mossy Cell Circuit Plasticity after Status Epilepticus. ( Butler, CR; Schnell, E; Westbrook, GL, 2022) |
| " In the present study, we aimed to investigate the effects of adjudin on pilocarpine-induced status epilepticus (SE) and its role in the regulation of reactive gliosis and neuroinflammation." | 4.12 | Adjudin prevents neuronal damage and neuroinflammation via inhibiting mTOR activation against pilocarpine-induced status epilepticus. ( Jeong, KH; Kim, WJ; Park, S; Zhu, J, 2022) |
| "LiCl/pilocarpine status epilepticus (SE) induced in immature rats leads, after a latent period, to hippocampal hyperexcitability." | 4.12 | Adenosine Kinase Isoforms in the Developing Rat Hippocampus after LiCl/Pilocarpine Status Epilepticus. ( Fábera, P; Kubová, H; Mareš, P; Tsenov, G; Uttl, L, 2022) |
| "Beta-caryophyllene-treated animals presented fewer short-term recurrent seizures than vehicle-treated counterparts, suggesting an anticonvulsant effect after SE." | 4.12 | Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats. ( da Costa Sobral, KG; Fighera, MR; Furian, AF; Mallmann, MP; Mello, FK; Neuberger, B; Oliveira, MS; Royes, LFF, 2022) |
| "This study aimed to evaluate the potential neuroprotective effects of ketogenic diet (KD) against the neuronal disruptions induced by SE in lithium-pilocarpine rat model of status epilepticus (SE)." | 4.12 | Ameliorating effect of ketogenic diet on acute status epilepticus: Insights into biochemical and histological changes in rat hippocampus. ( Abdelsamad, MA; Amin, HAA; Sadik, NAH; Shaheen, AA; Shehata, NI, 2022) |
| " In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy." | 4.12 | Dopamine depletion in wistar rats with epilepsy. ( Becker, EL; Biase, CLCL; Carvalho, EGA; Castro, DN; Cavalcante, JBN; Costa, AF; Costa, MV; Costa, PJMS; de Melo, MR; Félix, VB; Leão, SABF; Leite, ML; Lima, JA; Lino, ATS; Moura, IMFB; Mousinho, KC; Pai, JD; Quintella, GB; Saldanha-Filho, AJM; Santos, SDBD; Silva, ATMD; Silva, JCD; Tavares, MMA; Trindade-Filho, EM; Vieira, JSS; Zambrano, LI, 2022) |
| ") was administered 3 h after the pilocarpine (pilo)-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 4.12 | The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats. ( Atanasova, D; Atanasova, M; Ioanidu, L; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| " In this study, we induced a generalized status epilepticus (SE) by systemic administration of lithium-pilocarpine to adult female rats." | 4.12 | Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain. ( Aripaka, SS; Bankstahl, JP; Bankstahl, M; Bascuñana, P; Mikkelsen, JD; Pazarlar, BA, 2022) |
| "Levetiracetam (LEV) suppresses the upregulation of proinflammatory molecules that occurs during epileptogenesis after status epilepticus (SE)." | 4.12 | Regulation of Inflammation-Related Genes through ( Hashimoto, R; Ishihara, Y; Itoh, K; Komori, R; Kono, T; Kozawa, C; Kubo, S; Matsuo, T; Yokota-Nakatsuma, A, 2022) |
| "Morphine is widely used in patients and has been reported to alter seizure threshold, but its role in the development of epilepsy is unknown." | 4.12 | Effect of morphine administration after status epilepticus on epileptogenesis in rats. ( Gupta, YK; Joshi, D; Katyal, J; Kumar, H, 2022) |
| "Intrahippocampal pilocarpine microinjection (H-PILO) induces status epilepticus (SE) that can lead to spontaneous recurrent seizures (SRS) and neurodegeneration in rodents." | 4.12 | Neuroprotective Effect of Exogenous Galectin-1 in Status Epilepticus. ( Amaral, MMC; Borbely, AU; Cummings, RD; de Araujo Costa, M; de Castro, OW; de Gusmão Taveiros Silva, NK; de Melo, IS; Dias-Baruffi, M; Donatti, ALF; Duzzioni, M; Fuzo, CA; Garcia-Cairasco, N; Gitaí, DLG; Mestriner, L; Pacheco, ALD; Santos, YMO; Silva, RS, 2022) |
| " The objective of the current study was to investigate the effects of endurance training, applied before and after pilocarpine (Pilo) administration, on status epilepticus (SE) severity, and its relation to epileptogenesis deleterious consequences during the chronic epileptic phase." | 4.12 | Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. ( Atanasova, M; Georgieva, K; Ioanidu, L; Nenchovska, Z; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y, 2022) |
| " In fact, decreased expression of ALOXE3 and elevated concentration of AA in the hippocampus was found after status epilepticus (SE) induced by pilocarpine." | 4.12 | Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility. ( Chen, SY; Gao, MM; Long, YS; Lu, P; Su, T; Sun, WW; Tang, HL; Zeng, XD; Zhang, H, 2022) |
| " First, at the beginning of epileptic chronic phase, 30 days post-pilocarpine-induced Status Epilepticus (SE)." | 4.02 | In vitro Oscillation Patterns Throughout the Hippocampal Formation in a Rodent Model of Epilepsy. ( Calcagnotto, ME; Righes Marafiga, J; Vendramin Pasquetti, M, 2021) |
| " Therefore, the present study hypothesized an antiepileptic potential of chondroitin sulfate (CS) in pentylenetetrazole-induced kindled epilepsy and pilocarpine-induced status epilepticus in mice." | 4.02 | Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice. ( Abdel-Daim, MM; Almeer, R; Kamel, M; Najda, A; Nurzyńska-Wierdak, R; Singh, M; Singh, S; Singh, TG, 2021) |
| " Here, we detected the VFRs in the hippocampal network and tracked their roles during status epilepticus (SE) in rats with pilocarpine-induced temporal lobe epilepsy (TLE)." | 4.02 | Roles of Very Fast Ripple (500-1000[Formula: see text]Hz) in the Hippocampal Network During Status Epilepticus. ( Cui, Y; Guo, D; Hao, J; Lin, Y; Niu, B; Xia, Y; Yao, D; Yu, L, 2021) |
| "LMR-101 is a bisphenol derivative of propofol, a short-acting general anesthetic, which is also used to manage status epilepticus (SE)." | 4.02 | LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors. ( An, L; Chen, T; Guo, S; Huang, X; Liu, L; Mei, Q; Sun, X; Tian, H; Wang, R; Zhao, Y, 2021) |
| " Epilepsy was induced by lithium-pilocarpine-induced status epilepticus." | 4.02 | Enriched environment ameliorates chronic temporal lobe epilepsy-induced behavioral hyperexcitability and restores synaptic plasticity in CA3-CA1 synapses in male Wistar rats. ( Annamalai, K; Kutty, BM; Nair, KP; Salaka, RJ; Shankaranarayana Rao, BS; Srikumar, BN, 2021) |
| "Mice were treated with either C108297 or vehicle for 10 days beginning one day after pilocarpine-induced status epilepticus." | 4.02 | The glucocorticoid receptor specific modulator CORT108297 reduces brain pathology following status epilepticus. ( Arafa, SR; Danzer, SC; Gaitonde, KD; Herman, JP; Kraus, KL; Packard, BA; Suru, V; Wulsin, AC, 2021) |
| ") was administered 3 h after the pilocarpine-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats." | 4.02 | Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy. ( Atanasova, D; Marinov, P; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J; Uzunova, Y; Yoanidu, L, 2021) |
| " Finally, we assessed PR regulation of epileptic seizures and status epilepticus (SE) induced by lithium-pilocarpine in female rats with the global deletion of PRs (PR knockout; PRKO) using video electroencephalography (-EEG)." | 4.02 | Limbic progesterone receptor activity enhances neuronal excitability and seizures. ( Batabyal, T; Joshi, S; Kapur, J; Labuz, A; Shiono, S; Sun, H; Williamson, J, 2021) |
| " Therefore, we investigated the expression pattern of GRIM-19 in the CA1 area of the hippocampus in 8-week-old male C57BL/6 mice following pilocarpine-induced status epilepticus (SE)." | 3.96 | Alteration of Gene Associated with Retinoid-interferon-induced Mortality-19-expressing Cell Types in the Mouse Hippocampus Following Pilocarpine-induced Status Epilepticus. ( Hwang, SN; Kim, JC; Kim, SY, 2020) |
| " We used the lithium-pilocarpine-induced epilepsy model in adolescent Sprague-Dawley rats in order to evaluate hippocampal neurogenesis and epileptogenesis following the onset of status epilepticus (SE)." | 3.96 | The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis. ( Chen, H; Chen, J; Cheng, L; Han, W; Jiang, L; Xie, L; Yuan, P, 2020) |
| " Our further findings revealed that treatment with SR9009 inhibited NLRP3 inflammasome activation, inflammatory cytokine (IL-1β, IL-18, IL-6, and TNF-α) production, astrocytosis, microgliosis, and neuronal damage in the hippocampus after SE." | 3.96 | Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model. ( He, J; Liu, S; Shen, K; Wei, Y; Wu, K; Yang, H; Yang, X; Yue, J; Zhang, C, 2020) |
| " Here, in this study, we observed a significant increase in neuroinflammation and in the proliferation and survival of newborn granular cells in the hippocampus of pilocarpine-induced status epilepticus (SE) mice." | 3.96 | Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice. ( Gan, G; Ge, Q; Liu, X; Niu, D; Yang, J; Yao, H; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2020) |
| " Therefore, in the present study, we investigated the expression of parvalbumin (PV), one of the calcium-binding proteins, and morphological changes in the rat main olfactory bulb (MOB) following pilocarpine- induced status epilepticus (SE)." | 3.96 | Altered expression of parvalbumin immunoreactivity in rat main olfactory bulb following pilocarpine-induced status epilepticus. ( Kim, DS; Park, DK; Yoo, DY; Yu, YH, 2020) |
| " In the study, we established a mouse model of status epilepticus (SE) with pilocarpine and a cell model of TLE." | 3.96 | Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice. ( Chen, C; Cheng, X; Lian, Y; Xie, N; Xu, H; Zhang, H; Zheng, Y, 2020) |
| " To investigate role of miRNA in the latent stage following status epilepticus, we first compared microRNA expression profiles in mice hippocampus at 1 week after pilocarpine-induced status epilepticus (SE) vs." | 3.96 | Identification of microRNA-target genes in mice hippocampus at 1 week after pilocarpine-induced status epilepticus. ( Liu, JX; Liu, LF; Ma, YB; Si, KW; Tan, J; Tong, H; Wu, XL; Xiao, XL; Zhou, JS, 2020) |
| " Therefore, in the present study, SB203580 was used to inhibit the p38 MAPK signaling pathway in rats, and the expression levels of A1R and ENT1 in the brain tissue of rats with acute LiCl‑pilocarpine‑induced status epilepticus was detected." | 3.96 | Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1. ( Chen, Q; Chen, Y; Feng, Z; Huang, H; Peng, Y; Wang, J; Xu, Z; Zeng, J; Zhang, H; Zhang, J; Zhou, X, 2020) |
| "The lithium-pilocarpine model in rats is commonly used to study the characteristic events of acute status epilepticus (SE), epileptogenesis and temporal lobe epilepsy (TLE)." | 3.96 | Time course evaluation of lacosamide alone and in polypharmacy on behavioral manifestations and oxidative stress in lithium-pilocarpine-induced model. ( Alaqil, FA; Alasmari, AF; Alasmari, F; Alotaibi, FM; Alqahtani, F; Alqarni, SA; Anjum, SMM; Imran, I; Javaid, S; Rasool, MF; Samad, N; Shakeel, W, 2020) |
| "The present study aimed to evaluate the effect of topiramate (TPM) and lacosamide (LCM) on the emotional and cognitive re-sponses in naive animals and in animals with pilocarpine-induced status epilepticus." | 3.96 | The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model. ( Georgieva, K; Ivanova, N; Nenchovska, Z; Peychev, L; Shishmanova-Doseva, M; Tchekalarova, J, 2020) |
| "Based on combined behavioral, biochemical, and physiological analyses, we assessed the impact on animal well-being and condition in different phases of the pilocarpine post-status epilepticus (SE) model in rats." | 3.91 | Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model. ( Di Liberto, V; Hellweg, R; Koska, I; Möller, C; Palme, R; Potschka, H; Seiffert, I; van Dijk, RM, 2019) |
| " In the CA1 region of hippocampus less GABAergic activity precede the appearance of spontaneous seizures and calpain overactivation has been detected after chemoconvulsant-induced status epilepticus (SE)." | 3.91 | Calpain-dependent cleavage of GABAergic proteins during epileptogenesis. ( González, MI, 2019) |
| "Rosiglitazone reverses microglial polarization in the brains of SE mice and also affords neuroprotection against pilocarpine-induced status epilepticus without inducing significant changes in brain inflammation." | 3.91 | Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus. ( Guan, Y; Hao, Y; Li, Y; Peng, J; Wang, K; Xiang, W, 2019) |
| " We followed up progressive preclinical investigation in mice against pilocarpine (PILO)-induced status epilepticus (SE) and temporal lobe epilepsy (TLE)." | 3.91 | The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. ( Alam, MS; Ansari, MA; Ashraf, GM; Barkat, MA; Barreto, GE; Javed, MN; Khan, A; Maqbool, A; Nigar, S; Pottoo, FH; Rasheed, R; Tabassum, N, 2019) |
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 3.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| " Histological analysis and electrocorticograms (ECoG) were performed in animals fed with and without hypercholesterolemic diet before and during the status epilepticus induced by pilocarpine." | 3.91 | Can a hypercholesterolemic diet change the basal brain electrical activity and during status epilepticus in rats? ( Costa, EVL; da Silva, ELA; Nogueira, RA; Pessoa, DT, 2019) |
| " Using serial hippocampal microdialysis collections starting two weeks after the pilocarpine-induced status epilepticus, we evaluated how this chronic epilepsy model affects molecule levels and their interactions." | 3.91 | Chemical biomarkers of epileptogenesis and ictogenesis in experimental epilepsy. ( Gliske, SV; Kennedy, RT; Luna-Munguia, H; Stacey, WC; Zestos, AG, 2019) |
| " We aim in this study to investigate the neuroprotective effects of GL in a rat model after lithium-pilocarpine-induced status epilepticus (SE)." | 3.91 | Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus. ( Gao, F; Li, YJ; Wang, L; Yang, CM; Zhang, B, 2019) |
| " Some characteristic aftermaths of pilocarpine-induced status epilepticus (SE) in the immature rat are nerve cell loss and rearrangement of neuronal fibers." | 3.91 | Early Aberrant Growth of Mossy Fibers after Status Epilepticus in the Immature Rat Brain. ( Konoplew, A; Niquet, J; Rami, A, 2019) |
| " In this study we used the pilocarpine-induced status epilepticus model of TLE (i." | 3.91 | Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy. ( Derera, ID; Smith, BN; Smith, KC, 2019) |
| " Next, we tested an intravenous preparation of CBD (10 mg/kg single dose) in a rat model of pilocarpine-induced status epilepticus." | 3.91 | Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. ( Barker-Haliski, M; Bazelot, M; Glyn, S; Jones, N; McNeish, AJ; Patra, PH; Sandhu, H; Whalley, BJ; White, HS; Williams, CM, 2019) |
| "To investigate possible correlations between serum S100B levels and microglial/astrocytic activation in status epilepticus (SE) in lithium-pilocarpine-exposed rat hippocampi and whether serum S100B levels linearly reflect neuroinflammation." | 3.91 | The Effects of Minocycline on the Hippocampus in Lithium- Pilocarpine Induced Status Epilepticus in Rat: Relations with Microglial/Astrocytic Activation and Serum S100B Level. ( Atilla, P; Aydemir, O; Barun, S; Bulduk, EB; Kiziltas, M; Kurt, G; Muftuoglu, S; Oktem, M; Turhan, T, 2019) |
| " The aim of the present study was to determine if modulation by PPAR-γ could attenuate pilocarpine-induced seizures and decrease neuronal excitability." | 3.91 | The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity. ( Chu, FL; Huang, CW; Hung, TY; Wu, DC; Wu, SN, 2019) |
| " We investigated the effect of early administration of endocannabinoid receptor agonist WIN-55,212-2 on the development of spontaneous seizures, long-term behavioral and memory impairments, and neurodegeneration in the hippocampus on the lithium-pilocarpine model of status epilepticus (SE)." | 3.91 | Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model. ( Borisova, MA; Suleymanova, EM; Vinogradova, LV, 2019) |
| " Status epilepticus (SE) was induced via systemic injection of pilocarpine." | 3.91 | Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment. ( Huang, H; Huang, M; Lin, R; Lin, W; Liu, C; Ma, Y; Wen, Y, 2019) |
| " Accordingly, in the present study, we sought to explore whether TRPV4 is involved in the regulation of Cx expression following pilocarpine-induced status epilepticus (PISE) in mice." | 3.91 | Transient receptor potential vanilloid 4 is involved in the upregulation of connexin expression following pilocarpine-induced status epilepticus in mice. ( An, D; Chen, L; Men, C; Qi, M; Wang, Z; Xu, W; Zhan, Y; Zhou, L, 2019) |
| "This study aimed to investigate whether 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor with anti-inflammatory effects, could alleviate spontaneous recurrent seizures (SRS) and epilepsy-associated depressive behaviours in the lithium chloride (LiCl)-pilocarpine-induced post-status epilepticus (SE) rat model." | 3.91 | Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. ( Chen, Q; Ding, J; Hammock, BD; Li, D; Liu, J; Peng, W; Shen, Y; Wang, X; Yang, J, 2019) |
| "Adult female rats that developed epilepsy following lithium-pilocarpine-induced status epilepticus (SE) were used." | 3.91 | Progesterone receptor activation regulates seizure susceptibility. ( Joshi, S; Kapur, J; Shiono, S; Williamson, J, 2019) |
| " Poststatus epilepticus model of TLE induced by pilocarpine in rodents has enhanced the understanding of the processes leading to epilepsy and thus, of potential targets for antiepileptogenic therapies." | 3.88 | Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis. ( Canzian, JM; Duarte, MMMF; Duarte, T; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS, 2018) |
| " Here, we investigated the effects of triheptanoin against changes of hippocampal mitochondrial functions, oxidative stress and cell death induced by pilocarpine-induced status epilepticus (SE) in mice." | 3.88 | Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. ( Borges, K; Carrasco-Pozo, C; Simmons, D; Tan, KN, 2018) |
| " This study aimed to investigate the role of mitochondrial Rho (Miro) 1 in epilepsy, using a mouse model of pilocarpine-induced status epilepticus (SE)." | 3.88 | Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy. ( Lian, Y; Xie, N; Zhang, H; Zheng, Y, 2018) |
| " In the present study, we found that PEA15 was distinctly phosphorylated in reactive astrocytes and apoptotic astrocytes in the rat hippocampus following LiCl-pilocarpine-induced status epilepticus (SE, a prolonged seizure activity)." | 3.88 | The differential roles of PEA15 phosphorylations in reactive astrogliosis and astroglial apoptosis following status epilepticus. ( Kang, TC; Park, JY, 2018) |
| "Although convulsive seizures occurring during pilocarpine-induced epileptogenesis have received considerable attention, nonconvulsive seizures have not been closely examined, even though they may reflect the earliest signs of epileptogenesis and potentially guide research on antiepileptogenic interventions." | 3.88 | Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus. ( Barth, DS; Benison, AM; Bercum, FM; Dudek, FE; Smith, ZZ, 2018) |
| " In this study, the expression of Cx36 was investigated in the mouse hippocampus at 1 h, 4 h during pilocarpine-induced status epilepticus (PISE) and 1 week, 2 months after PISE." | 3.88 | Cx36 in the mouse hippocampus during and after pilocarpine-induced status epilepticus. ( Huo, YW; Lu, M; Ma, DM; Tang, FR; Wu, XL; Zhang, W; Zhou, JS, 2018) |
| " Considering the importance in developing therapeutic strategies to prevent or modify epileptogenesis, we aimed the present study to test the hypothesis that atorvastatin modifies seizure susceptibility of mice after status epilepticus (SE)." | 3.88 | Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis. ( Fighera, MR; Furian, AF; Oliveira, CV; Oliveira, MS; Royes, LFF; Zorzi, VN, 2018) |
| " In this study, the mice were injected with methylazoxymethanol acetate (MAM) both before and after pilocarpine-induced status epilepticus (SE) to achieve an overall ablation of newborn cells contributing to the pathological recruitment." | 3.88 | Ablation of aberrant neurogenesis fails to attenuate cognitive deficit of chronically epileptic mice. ( Feng, GF; Hu, M; Li, CJ; Liu, JX; Liu, Y; Xu, JH; Yuan, B; Zhu, K, 2018) |
| " Therefore, hippocampal Pol1 activity was examined in mouse models of epilepsy including kainic acid- and pilocarpine-induced status epilepticus (SE) as well as a single seizure in response to pentylenetetrazole (PTZ)." | 3.88 | RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy. ( Hetman, M; Kolikonda, M; Naik, SP; Parlato, R; Pietrzak, M; Slomnicki, LP; Smith, SC; Vashishta, A, 2018) |
| " The present pilot study aims to investigate whether liraglutide alleviates the chronic inflammation response and mitochondrial stress induced by SE in the lithium-pilocarpine animal model." | 3.88 | Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. ( Feng, P; Hölscher, C; Li, DF; Tian, MJ; Wang, RF; Xue, GF; Zheng, JY, 2018) |
| " The analysis was performed in three conditions: naïve, during latent phase after pilocarpine-induced status epilepticus and after 21 days of transauricular electric shocks." | 3.88 | Profiles of gene expression in the hippocampal formation of rats with experimentally-induced brain dysplasia. ( Gzielo, K; Janeczko, K; Kielbinski, M; Setkowicz, Z, 2018) |
| "Currently, lacosamide (LCM) is not approved for use in status epilepticus (SE) but several shreds of evidence are available to support its use." | 3.88 | Inverted-U response of lacosamide on pilocarpine-induced status epilepticus and oxidative stress in C57BL/6 mice is independent of hippocampal collapsin response mediator protein-2. ( Nirwan, N; Siraj, F; Vohora, D, 2018) |
| " In addition, pilocarpine-induced neuronal damage and spontaneously recurrent seizures were evaluated after equivalent chemoconvulsant-induced status epilepticus was achieved by coadministration of the M-current-specific channel inhibitor, XE991." | 3.88 | Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden and prevents status epilepticus-induced neuronal death and epileptogenesis. ( Greene, DL; Hoshi, N; Kosenko, A, 2018) |
| " The GA group was given GA (150 μg/kg, ip) and the control group was given a saline injection prior to pilocarpine-induced seizures." | 3.88 | The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures. ( Huang, CW; Lai, MC; Lin, KM; Wu, SN; Yeh, PS, 2018) |
| "To investigate the spatiotemporal expression of cannabinoid receptor type 2 (CB2R) in the hippocampus of pilocarpine-treated rats experiencing a status epilepticus (SE)." | 3.88 | The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus. ( Wang, H; Wu, Q, 2018) |
| " Thus, we evaluated SV2A protein expression throughout the hippocampi of lithium-pilocarpine rats after status epilepticus (SE) and during early and late epilepsy." | 3.88 | Differential expression of synaptic vesicle protein 2A after status epilepticus and during epilepsy in a lithium-pilocarpine model. ( Contreras-García, IJ; Gómez-González, B; Mendoza Torreblanca, JG; Pichardo-Macías, LA; Ramírez-Hernández, R; Rocha, L; Sánchez-Huerta, K; Santana-Gómez, CE, 2018) |
| " This study aims at investigating AO effects on (i) latency to first seizure, seizure severity, weight loss, mortality rate, (ii) lipid peroxidation level, nitrite level, and catalase activity in the hippocampus after SE induced by pilocarpine (PC)." | 3.88 | Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats. ( Ammouri, H; Bahbiti, Y; Berkiks, I; Bikjdaouene, L; Chakit, M; Hessni, AE; Mesfioui, A; Nakache, R; Ouichou, A, 2018) |
| "Vascular endothelial growth factor (VEGF) treatment during pilocarpine-induced status epilepticus (SE) causes sustained preservation of behavioral function in rats in the absence of enduring neuroprotection (Nicoletti et al." | 3.85 | VEGF treatment during status epilepticus attenuates long-term seizure-associated alterations in astrocyte morphology. ( Croll, SD; Lenzer-Fanara, JR; Li, T; Payen, F; Salerni, EA, 2017) |
| " In this study, we ablated the hippocampal neurogenesis by methylazoxymethanol acetate (MAM) treatment both before and after pilocarpine induced status epilepticus (SE)." | 3.85 | Reduced abnormal integration of adult-generated granule cells does not attenuate spontaneous recurrent seizures in mice. ( Feng, GF; Hu, M; Liu, JX; Liu, Y; Yuan, B; Zhu, K, 2017) |
| "Status epilepticus (SE) was induced via lithium pilocarpine in adult rats, and seizures were assessed by continuous video-electroencephalography (EEG) monitoring." | 3.85 | Neurosteroid-sensitive δ-GABA ( Joshi, S; Kapur, J; Rajasekaran, K; Williamson, J, 2017) |
| "The status epilepticus (SE) induced by lithium-pilocarpine is a well characterized rodent model of the human temporal lobe epilepsy (TLE) which is accompanied by severe brain damage." | 3.85 | Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model. ( Bankstahl, JP; Bascuñana, P; Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MA; Shiha, AA; Silván, Á, 2017) |
| " We have investigated whether the intrinsic firing response gain, quantified by the slope of the function relating the number of evoked spikes (Ns) to input excitatory current intensity (I), is modified in principal rat hippocampal neurons in the pilocarpine-status epilepticus (SE) model of TLE." | 3.85 | Plasticity of intrinsic firing response gain in principal hippocampal neurons following pilocarpine-induced status epilepticus. ( Daninos, M; Tamir, I; Yaari, Y, 2017) |
| " In epileptic rats analyzed up to approximately two weeks after pilocarpine-induced status epilepticus (SE), these patterns are associated with specific high-frequency oscillation (HFO) content: ripples (80-200Hz) or fast-ripples (250-500Hz) predominate in LVF or HYP seizures, respectively." | 3.85 | Time-dependent evolution of seizures in a model of mesial temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M; Stroh, T, 2017) |
| "This study aims to investigate the role of zolpidem in lithium-pilocarpine induced status epilepticus (SE) and probable mechanisms involved in seizure threshold alteration." | 3.85 | Involvement of nitrergic system in anticonvulsant effect of zolpidem in lithium-pilocarpine induced status epilepticus: Evaluation of iNOS and COX-2 genes expression. ( Bahremand, T; Dehpour, AR; Eslami, SM; Ghasemi, M; Gholami, M; Momeny, M; Sharifzadeh, M, 2017) |
| " The rats in the model group were injected intraperitoneally with lithium chloride-pilocarpine hydrochloride to establish the rat model of status epilepticus (SE)." | 3.85 | The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus. ( Chen, L; Chen, S; Gao, Q; Hu, K; Jiang, D; Luo, W; Ouyang, D; Xiao, B; Xiao, J; Zeng, G; Zeng, X; Zhou, L; Zong, W, 2017) |
| " In order to delineate the immune response following pilocarpine-induced status epilepticus (SE) in the mouse, we monitored the kinetics of leukocyte presence in the hippocampus over the period of four weeks." | 3.85 | Mycophenolate mofetil prevents the delayed T cell response after pilocarpine-induced status epilepticus in mice. ( Abele, J; Engelmann, R; Kirschstein, T; Köhling, R; Müller-Hilke, B; Neumann, AM; Sellmann, T, 2017) |
| " Epileptogenesis was initiated using the pilocarpine status epilepticus model in male and female mice." | 3.85 | Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression. ( Danzer, SC; Hosford, BE; Liska, JP; Rowley, S, 2017) |
| " When the brain slices were prepared from mice which underwent a pilocarpine-induced status epilepticus or when brain slices were incubated in pilocarpine-containing external medium, the sensitivity of P2X7 and P2Y1 receptors was invariably increased." | 3.85 | Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus. ( Araújo, MGL; Fernandes, MJS; Franke, H; Gao, P; Illes, P; Khan, MT; Krügel, U; Liu, J; Rong, W; Rozmer, K; Tang, Y, 2017) |
| " By utilizing a combination of behavioral surveys, immunofluorescence and electrophysiological recordings, the present study characterized the anticonvulsant effect of GAS in a pilocarpine-induced status epilepticus (SE) rat model of TLE and explored the underlying cellular mechanisms." | 3.85 | Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents. ( Cao, XY; Hong, P; Ji, WG; Qi, AP; Shao, H; Yang, Y; Zhu, GX; Zhu, ZR, 2017) |
| " In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE)." | 3.85 | TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice. ( Abramowitz, J; Birnbaumer, L; Cozart, MA; Mock, MM; Phelan, KD; Shwe, UT; Wu, H; Zheng, F, 2017) |
| " Using the lithium-pilocarpine model of temporal lobe epilepsy (TLE), we recently showed that inhibition of this receptor during the first ten days after pilocarpine-induced status epilepticus (SE) results in substantial anti-epileptogenic and neuroprotective effects." | 3.85 | Effects of protease-activated receptor 1 inhibition on anxiety and fear following status epilepticus. ( Bogovyk, R; Fedoriuk, M; Holmes, GL; Isaev, D; Isaeva, E; Krishtal, O; Lunko, O, 2017) |
| " We hypothesized that pilocarpine-induced status epilepticus would disrupt oscillations and behavioral performance and that electrical neuromodulation to entrain theta would improve cognition specifically in injured rats." | 3.85 | Stimulation of the medial septum improves performance in spatial learning following pilocarpine-induced status epilepticus. ( Echeverri, A; Gurkoff, GG; Izadi, A; Lee, DJ; Melnik, M; Seidl, S; Shahlaie, K, 2017) |
| "This study aimed to determine the role C5aR1 plays in mediating immune responses acutely after pilocarpine-induced status epilepticus (SE), specifically those of brain-infiltrating leukocytes." | 3.85 | The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus. ( Benson, MJ; Borges, K; Manzanero, S, 2017) |
| "Role of lithium chloride and paraldehyde in acute changes after lithium-pilocarpine status epilepticus (SE) induced at postnatal day 12 was studied in 15-day-old rats." | 3.85 | Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats? ( Kubová, H; Mareš, P; Tsenov, G, 2017) |
| "The intracranial EEG was continuously registered in Krushinskii-Molodkina rats with inherited susceptibility to audiogenic seizures and in Wistar rats, which are resistant to the audiogenic convulsions in the lithium-pilocarpine model of status epilepticus (SE)." | 3.83 | [CHANGES IN BRAIN ELECTRICAL ACTIVITY PATTERNS IN RATS WITH DIFFERENT SUSCEPTIBILITY TO SEIZURES IN LITHIUM-PILOCARPINE MODEL OF STATUS EPILEPTICUS]. ( Kim, KK; Lukomskaya, NY; Magazanik, LG; Vataev, SI; Zaitsev, AV, 2016) |
| "It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium-pilocarpine model of status epilepticus (SE) in rats." | 3.83 | Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2016) |
| " In the present study, we examined the time-course changes of neuronal degeneration and hippocalcin protein level in the mouse hippocampus following pilocarpine-induced status epilepticus (SE)." | 3.83 | Time-course changes of hippocalcin expression in the mouse hippocampus following pilocarpine-induced status epilepticus. ( Choi, HS; Lee, CH, 2016) |
| " During status epilepticus, ACh levels were increased threefold but returned to baseline after the termination of seizures by diazepam." | 3.83 | Extracellular levels of ATP and acetylcholine during lithium-pilocarpine induced status epilepticus in rats. ( Imran, I; Klein, J; Lietsche, J, 2016) |
| " In this study, we investigated how DGC birthdate influences participation in MFS and other aspects of axonal plasticity using the rat pilocarpine-induced status epilepticus (SE) model of mTLE." | 3.83 | Axonal plasticity of age-defined dentate granule cells in a rat model of mesial temporal lobe epilepsy. ( Althaus, AL; Parent, JM; Zhang, H, 2016) |
| " Lithium-pilocarpine model of seizures in rodents reproduces many features of human convulsive status epilepticus (SE) and subsequent TLE." | 3.83 | Structural alterations in the rat brain and behavioral impairment after status epilepticus: An MRI study. ( Abbasova, KR; Gulyaev, MV; Suleymanova, EM, 2016) |
| " Using the pilocarpine-induced status epilepticus (SE) model of epilepsy, we find that the basic physiological characteristics of AC-INs in epileptic rats are not different from age-matched controls." | 3.83 | Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy. ( Proddutur, A; Santhakumar, V; Swietek, B; Yu, J, 2016) |
| " In the present study the pilocarpine-induced status epilepticus (SE) model of TLE was used to study the regulation of CRTC1 during and following SE." | 3.83 | CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy. ( Dubey, D; Porter, BE, 2016) |
| " Herein, we confirmed that pilocarpine application promptly (<30 min) induces status epilepticus (SE) as revealed by changes in rat electrocorticogram particularly in fast-beta range (21-30 Hz)." | 3.83 | Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons. ( Britto, LR; Damico, MV; de Sousa, E; Higa, GS; Kihara, AH; Kinjo, ER; Morya, E; Santos, BA; Valle, AC; Walter, LT, 2016) |
| " We performed long-term video-EEG monitoring of 16 epileptic rats after pilocarpine-induced status epilepticus and five control animals." | 3.83 | Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats. ( Bajorat, R; Brenndörfer, L; Goerss, D; Kirschstein, T; Köhling, R; Schwabe, L, 2016) |
| " To determine if mTOR activation is necessary for abnormal granule cell development, transgenic mice that harbored fluorescently-labeled adult-born granule cells were treated with rapamycin following pilocarpine-induced status epilepticus." | 3.83 | Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain. ( Danzer, SC; Garcia-Cairasco, N; Hester, MS; Hosford, BE; LaSarge, CL; Liska, JP; Rolle, IJ; Santos, VR; Singh, SP, 2016) |
| "5h with pilocarpine to study anxiety-related behaviors, changes in the electroencephalogram of the cerebral cortex and hippocampus, and expression of hippocampal proteins." | 3.83 | Dual mechanisms of rapid expression of anxiety-related behavior in pilocarpine-treated epileptic mice. ( Iida, Y; Itakura, M; Miyaoka, H; Ohkido, T; Otsuka, S; Saito, M; Takahashi, M; Watanabe, S; Yamamori, S, 2016) |
| " Here, we used a FACS-based approach to discriminate between microglia and myeloid infiltrates isolated from the hippocampus 24 h and 96 h after status epilepticus (SE) in pilocarpine-treated CD1 mice." | 3.83 | Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus. ( Biagini, G; Boddeke, HW; Bordini, D; Curia, G; Dominici, M; Eggen, BJ; Giordano, C; Spano, C; Vainchtein, ID; Vinet, J, 2016) |
| " Lithium chloride- and pilocarpine-induced status epilepticus (LiCl/Pilo-SE) in rodents represents a model of severe seizures that result in development of temporal lobe epilepsy (TLE)." | 3.83 | Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors. ( Druga, R; Ergang, P; Kubová, H; Mareš, P; Salaj, M; Szczurowska, E, 2016) |
| " In this study, we investigated the chronic effects of hypoxic preconditioning on spontaneous recurrent seizures (SRS), neuronal death, and spatial memory performance in rats subjected to pilocarpine (Pilo)-induced status epilepticus (SE)." | 3.83 | Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia. ( Balista, PA; Bassi, M; Do Val-da Silva, RA; Galvis-Alonso, OY; Glass, ML; Leite, JP; Peixoto-Santos, JE; Romcy-Pereira, RN; Scandiuzzi, RC, 2016) |
| " During pilocarpine induced status epilepticus, a transient down-regulation of neuronal CCR6 in the stratum oriens of CA1 was demonstrated at 2h during status epilepticus." | 3.83 | Altered expression of neuronal CCR6 during pilocarpine induced status epilepticus in mice. ( Cao, X; Liu, JX; Liu, Y; Tang, FR, 2016) |
| ") gabapentin (GBP), carbamazepine (CBZ) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on learning and memory, anxiety, and locomotor activity in rats with lithium-pilocarpine-induced status epilepticus (SE)." | 3.83 | Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats. ( Gulec Suyen, G; Isbil-Buyukcoskun, N; Kahveci, N; Ozluk, K; Sengun, E, 2016) |
| " The aims of the present study were to evaluate GL scavenging properties and to investigate GL's effect on oxidative stress and inflammation in the lithium/pilocarpine-induced seizure model in two cerebral regions, hippocampus and olfactory bulb, at acute time intervals (3 or 24h) after status epilepticus (SE)." | 3.83 | Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats. ( González-Reyes, S; Guevara-Guzmán, R; Jiménez-Osorio, AS; Pedraza-Chaverri, J; Santillán-Cigales, JJ, 2016) |
| " Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE." | 3.83 | Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. ( Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV, 2016) |
| " Induction of status epilepticus (SE) by Li-pilocarpine was performed on groups G2-G7." | 3.83 | The effect of some immunomodulatory and anti-inflammatory drugs on Li-pilocarpine-induced epileptic disorders in Wistar rats. ( Al Ghamdi, S; ALrefai, AA; Alshareef, A; Bin Sef, B; Borham, LE; Ibrahim, IAA; Khan, M; Labib, AA; Mahfoz, AM; Milibary, A; Shahzad, N, 2016) |
| " Using combined methods of behavioral testing, immunofluorescence and electrophysiological recordings, we characterized the anticonvulsant effect of RIN in a pilocarpine-induced status epilepticus (SE) rat model of temporal lobe epilepsy (TLE) and investigated the underlying cellular mechanisms." | 3.83 | Anticonvulsant effect of Rhynchophylline involved in the inhibition of persistent sodium current and NMDA receptor current in the pilocarpine rat model of temporal lobe epilepsy. ( Ji, WG; Mi, Z; Qi, AP; Shao, H; Yang, Y; Zhu, GX; Zhu, ZR, 2016) |
| " Here, we perform a miRNA microarray analysis of the hippocampus of Wistar rats 24 hours after intra-hippocampal pilocarpine-induced Status Epilepticus (H-PILO SE)." | 3.83 | Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis. ( Araújo, MA; Arroxelas-Silva, CL; Castro, OW; Duzzioni, M; Garcia-Cairasco, N; Góes Gitaí, DL; Kandratavicius, L; Leite, JP; Marques, TE; Octacílio-Silva, S; Paçó-Larson, ML; Passos, GA; Peixoto-Santos, JE; Pereira, MG, 2016) |
| " Here, we show that the biogenesis of miR-21 is altered following pilocarpine-induced status epilepticus (SE) with an increase in precursor miR-21 (pre-miR-21) in rats." | 3.83 | Increased precursor microRNA-21 following status epilepticus can compete with mature microRNA-21 to alter translation. ( Chak, K; Kay, MA; Kemp, KC; Kim, HK; Porter, BE; Roy-Chaudhuri, B, 2016) |
| "To study the effect of a microRNA-132 antagonist on lithium-pilocarpine-induced status epilepticus (SE) in young Sprague-Dawley (SD) rats." | 3.83 | [Effect of a microRNA-132 antagonist on pilocarpine-induced status epilepticus in young rats]. ( Kong, HM; Li, LH; Peng, J; Wu, TH; Yin, F, 2016) |
| " In the present study, we measured dendritic spine volume in mice injected with miR-134-targeting antagomirs and tested effects of the antagomirs on status epilepticus triggered by the cholinergic agonist pilocarpine." | 3.81 | Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus. ( Conroy, RM; deFelipe, J; Engel, T; Fernaud-Espinosa, I; Henshall, DC; Jimenez-Mateos, EM; McKiernan, RC; Merino-Serrais, P; Reschke, CR; Reynolds, J; Rodriguez-Alvarez, N, 2015) |
| "2 promoter activation, were imaged in vivo in the pilocarpine model of status epilepticus (SE)." | 3.81 | Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice. ( Becker, AJ; Kulbida, R; Mandelkow, EM; Schoch, S; van Loo, KM; Wang, Y, 2015) |
| " We investigated the effects of ketogenic diets (KDs) containing coconut oil, triheptanoin, or soybean oil on pilocarpine-induced status epilepticus (SE) in rats." | 3.81 | Effects of ketogenic diets on the occurrence of pilocarpine-induced status epilepticus of rats. ( Barros, EM; Bueno, NB; Cabral-Junior, CR; da Rocha Ataide, T; Domingos, BR; Ferreira, RC; Galvão, JA; Gama, IR; Melo, IT; Oliveira, SL; Pereira, WS; Trindade-Filho, EM, 2015) |
| " We measured the expression of two subtypes of TRPC channels, TRPC3 and TRPC6, in temporal lobe epileptic foci excised from patients with intractable epilepsy and in hippocampus of mice with pilocarpine-induced status epilepticus (SE), an animal model of TLE." | 3.81 | Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy. ( Feng, L; Jiang, T; Liu, R; Long, X; Ma, Y; Tang, W; Tian, F; Xiao, B; Yuan, C; Zeng, C; Zhou, P, 2015) |
| "Inhibiting the mammalian target of rapamycin (mTOR) signaling pathway with rapamycin blocks granule cell axon (mossy fiber) sprouting after epileptogenic injuries, including pilocarpine-induced status epilepticus." | 3.81 | Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Thind, K; Yamawaki, R, 2015) |
| "Pentylenetetrazol (PTZ)-induced chronic kindling model and lithium-pilocarpine-induced status epilepticus (SE) model were used in this study." | 3.81 | Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. ( Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 3.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "Experiments were designed to evaluate changes in the histamine release, mast cell number and neuronal damage in hippocampus induced by status epilepticus." | 3.81 | The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus. ( Orozco-Suárez, SA; Rocha, L; Santana-Gómez, CE; Valle-Dorado, MG, 2015) |
| " In the present study we studied seizure susceptibility along the longitudinal axis of the hippocampus following pilocarpine-induced status epilepticus (SE)." | 3.81 | Status epilepticus results in region-specific alterations in seizure susceptibility along the hippocampal longitudinal axis. ( Holmes, GL; Isaev, D; Isaeva, E; Romanov, A, 2015) |
| " Here we have examined hippocampal neuronal network activities in the pilocarpine post-status epilepticus model of limbic epileptogenesis and asked whether or not the docosahexaenoic acid (DHA)-derived lipid mediator, neuroprotectin D1 (NPD1), modulates epileptogenesis." | 3.81 | Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. ( Bazan, NG; Musto, AE; Petasis, NA; Walker, CP, 2015) |
| " To further address this issue, we investigated the progressive changes of Cx 43 and Cx 40 in the mouse hippocampus at 4 h, 1 day, 1 week and 2 months during and after pilocarpine-induced status epilepticus (PISE)." | 3.81 | Astrocytic Cx 43 and Cx 40 in the mouse hippocampus during and after pilocarpine-induced status epilepticus. ( Lu, QY; Song, TB; Tang, FR; Tang, YC; Wu, XL; Xiao, XL, 2015) |
| "As a result of the growing availability of genetically engineered mouse lines, the pilocarpine post-status epilepticus (SE) model of temporal lobe epilepsy is increasingly used in mice." | 3.81 | Pilocarpine-induced convulsive activity is limited by multidrug transporters at the rodent blood-brain barrier. ( Bankstahl, JP; Bankstahl, M; Löscher, W; Römermann, K, 2015) |
| " Status epilepticus evoked by pilocarpine administeration was used to induce epilepsy in rats." | 3.81 | Dynamic Expression of MicroRNAs (183, 135a, 125b, 128, 30c and 27a) in the Rat Pilocarpine Model and Temporal Lobe Epilepsy Patients. ( Alsharafi, W; Xiao, B, 2015) |
| " Therefore, we modified kainic acid (KA)- and pilocarpine-induced status epilepticus (SE) models of epilepsy so that seizures were rare for the first months after SE, and conducted video-EEG during this time." | 3.81 | Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy. ( D'Amour, J; Fenton, AA; Friedman, D; LaFrancois, JJ; MacLusky, NJ; Magagna-Poveda, A; Moretto, J; Pearce, P; Scharfman, HE, 2015) |
| "The aim of the present study was to evaluate the effects of transcranial focal electrical stimulation (TFS) on γ-aminobutyric acid (GABA) and glutamate release in the hippocampus under basal conditions and during pilocarpine-induced status epilepticus (SE)." | 3.81 | Transcranial focal electrical stimulation reduces the convulsive expression and amino acid release in the hippocampus during pilocarpine-induced status epilepticus in rats. ( Alcántara-González, D; Bañuelos-Cabrera, I; Besio, W; Fernández-Mas, R; Luna-Munguía, H; Magdaleno-Madrigal, V; Rocha, L; Santana-Gómez, CE, 2015) |
| " In the present study, we investigated the roles of ER stress in vasogenic edema and its related events in rat epilepsy models provoked by pilocarpine-induced status epilepticus (SE)." | 3.81 | Endothelial NOS activation induces the blood-brain barrier disruption via ER stress following status epilepticus. ( Hyun, HW; Kim, JE; Kim, JY; Ko, AR, 2015) |
| " Diazepam produced a dose-dependent protection against 6-Hz seizures in control and pilocarpine mice, both at 2 weeks and 8 weeks after SE, but with a more pronounced increase in potency in post-SE animals at 2 weeks." | 3.81 | Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model. ( Kaminski, RM; Leclercq, K, 2015) |
| "Pilocarpine-induced status epilepticus causes a rapid increase of multiple cytokines in limbic and neocortical regions." | 3.81 | Increased CCL2, CCL3, CCL5, and IL-1β cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures. ( Arisi, GM; Foresti, ML; Katki, K; Shapiro, LA, 2015) |
| " In this study, we found that the MCU inhibitor Ru360 significantly attenuated neuronal death and exerted an anti-apoptotic effect on rat hippocampal neurons after pilocarpine-induced status epilepticus (SE), while the MCU activator spermine increased seizure-induced neuronal death and apoptosis." | 3.81 | Role of the Mitochondrial Calcium Uniporter in Rat Hippocampal Neuronal Death After Pilocarpine-Induced Status Epilepticus. ( Ge, X; Li, Y; Wang, C; Wang, M; Wang, Y; Xie, N, 2015) |
| "In a rat model of status epilepticus (SE) induced by lithium and pilocarpine and refractory to midazolam, deep hypothermia (20 °C for 30 min) reduced EEG power over 50-fold, stopped SE within 12 min, and reduced EEG spikes by 87%." | 3.81 | Deep hypothermia for the treatment of refractory status epilepticus. ( Baldwin, R; Gezalian, M; Niquet, J; Wasterlain, CG, 2015) |
| " In this study, we used the pilocarpine model of MTLE to establish the effects of a third generation drug, lacosamide (LCM), on seizures, interictal spikes and high-frequency oscillations (HFOs, ripples: 80-200 Hz, fast ripples: 250-500 Hz)." | 3.81 | Lacosamide modulates interictal spiking and high-frequency oscillations in a model of mesial temporal lobe epilepsy. ( Avoli, M; Behr, C; Lévesque, M; Ragsdale, D, 2015) |
| " Epileptic rats that developed spontaneous recurrent seizures after a pilocarpine-induced status epilepticus were treated with a KD or control diet (CD)." | 3.81 | Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats. ( Akula, KK; Boison, D; Coffman, SQ; Lusardi, TA; Masino, SA; Ruskin, DN, 2015) |
| " Based on this, we measured the serum levels of C-reactive protein (CRP) and cytokines during acute, silent, and chronic phases of rats submitted to the pilocarpine model of epilepsy." | 3.81 | High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process? ( Cysneiros, RM; de Almeida, SS; de Brito, MV; Gouveia, TL; Naffah-Mazzacoratti, Mda G; Nejm, MB; Oliva, ML; Salu, BR; Scorza, FA; Vieira de Brito, JM; Vieira de Sousa, PV, 2015) |
| "In the present study, we investigated whether endoplasmic reticulum (ER) stress is associated with neuronal- and astroglial-death in the hippocampus using LiCl-pilocarpine-induced status epilepticus (SE) rat model." | 3.81 | Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats. ( Hyun, HW; Kim, JE; Kim, JY; Ko, AR, 2015) |
| "The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy." | 3.81 | Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. ( Hillert, MH; Imran, I; Klein, J, 2015) |
| " To address the issue, newly generated cells in the sub-granular zone of the dentate gyrus were labeled by the proliferation marker bromodeoxyuridine (BrdU) or retroviral vector expressing green fluorescent protein 2 months after pilocarpine-induced status epilepticus." | 3.81 | Newly generated neurons at 2 months post-status epilepticus are functionally integrated into neuronal circuitry in mouse hippocampus. ( Chen, XL; Hu, M; Liu, JX; Liu, Y; Xiao, XL; Zhang, JS; Zhang, YJ; Zhu, K, 2015) |
| "Pilocarpine chemoconvulsant was used to induce status epilepticus." | 3.81 | Suppressing cAMP response element-binding protein transcription shortens the duration of status epilepticus and decreases the number of spontaneous seizures in the pilocarpine model of epilepsy. ( Bermudez, C; Dubey, D; Porter, BE; Zhu, X, 2015) |
| "Pilocarpine-induced status epilepticus (SE) is a widely used seizure model in mice, and the Racine scale has been used to index seizure intensity." | 3.81 | Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale. ( Greenfield, LJ; Phelan, KD; Shwe, UT; Williams, DK; Zheng, F, 2015) |
| "Inflammation was induced by injecting poly(I:C) (pIC 10 mg/kg, postnatal day 12-14), seizure was induced by injecting pilocarpine hydrochloride (PILO 200 mg/kg, postnatal day 15) into C57BL/6J mice, and the pIC+PILO mice were used as the iSE model (miSE)." | 3.81 | Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus. ( Hirai, S; Morio, T; Nakajima, K; Okado, H, 2015) |
| "In a previous study, we reported a persistent reduction of F-actin puncta but a compensating increase in puncta size in the mouse hippocampus at 2 months after pilocarpine-induced status epilepticus (Epilepsy Res." | 3.81 | The progressive changes of filamentous actin cytoskeleton in the hippocampal neurons after pilocarpine-induced status epilepticus. ( Dai, G; Hou, Y; Li, S; Li, Y; Liu, H; Liu, J; Song, Y; Tan, B; Xiong, T; Zhang, Y, 2015) |
| "Pilocarpine-induced status epilepticus (SE), which results in temporal lobe epilepsy (TLE) in rodents, activates the JAK/STAT pathway." | 3.80 | The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. ( Brooks-Kayal, AR; Carlsen, J; Cogswell, M; Del Angel, YC; Grabenstatter, HL; Russek, SJ; Wempe, MF; White, AM, 2014) |
| "Status epilepticus (SE) was induced by intraperitoneal injection of 340mg/kg pilocarpine, and terminated by diazepam after 40min." | 3.80 | Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizures. ( Groeneweg, L; Kirschstein, T; Köhling, R; Müller, L; Müller, S; Sellmann, T; Tokay, T, 2014) |
| "Present studies were carried out to decipher seizure-dependent changes in mitochondrial function and ultrastructure in rat hippocampus after status epilepticus (SE) induced by pilocarpine (PILO)." | 3.80 | Alteration of mitochondrial function and ultrastructure in the hippocampus of pilocarpine-treated rat. ( Gao, J; Liu, ZC; Ma, AJ; Pan, XD; Song, JH; Xie, AM; Yao, H; Zhang, L, 2014) |
| "We investigated localization of Phospholipase C beta (PLCβ1 and PLCβ4) in laminaes of dorsal hippocampus and different subtypes of hippocampal interneurons in normal Kunming mouse, and their progressive changes during pilocarpine induced status epilepticus (SE) by quantitative immunohistochemistry and real time PCR." | 3.80 | Reduced expression of Phospholipase C beta in hippocampal interneuron during pilocarpine induced status epilepticus in mice. ( Chen, XL; Hu, M; Liu, JX; Liu, Y; Xu, JH; Yang, PB; Zhang, JS, 2014) |
| "To investigate the possible role of bone marrow-derived cells in angiogenesis after seizures, we induced SE by pilocarpine injection in previously prepared chimeric mice." | 3.80 | Participation of bone marrow-derived cells in hippocampal vascularization after status epilepticus. ( Bittencourt, S; Covolan, L; Garcia, Kde O; Longo, BM; Mello, LE; Paiva, Dde S; Romariz, SA, 2014) |
| " Thus, the aim of the present study was to evaluate the effect of sleep deprivation in the expression of microRNA (miRNA) in the frontal cortex and heart tissues of adult male rats after 50days of saline (SAL) or pilocarpine-induced status epilepticus (PILO)." | 3.80 | The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus. ( Andersen, ML; Cavalheiro, EA; Guindalini, C; Matos, G; Mazzotti, DR; Scorza, FA; Tufik, S, 2014) |
| "Lithium chloride-pilocarpine-induced rats with status epilepticus (SE) were established." | 3.80 | Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy. ( Du, Y; Liu, W; Shi, R; Yang, W; Yu, W; Zhao, N; Zou, Y, 2014) |
| " Whereas MTA reduced the neuronal cell death in pilocarpine-induced status epilepticus and the size of the lesion in global but not focal ischemic brain damage, it was ineffective in preserving dopaminergic neurons of the substantia nigra in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-mice model." | 3.80 | Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. ( Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H, 2014) |
| "Thirty-five Sprague-Dawley rats were subjected to lithium-pilocarpine status epilepticus." | 3.80 | Attention and executive functions in a rat model of chronic epilepsy. ( Akimana, G; Barbelivien, A; Cassel, JC; Cosquer, B; Faure, JB; Ferrandon, A; Herbeaux, K; Koning, E; Marques-Carneiro, JE; Nehlig, A, 2014) |
| " After pilocarpine-induced status epilepticus (SE), increases in neurotrophins regulate a wide variety of cell-signaling pathways, including prosurvival and cell-death machinery in a receptor-specific manner." | 3.80 | Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. ( Brooks-Kayal, AR; Carlsen, J; Cruz Del Angel, Y; Gonzalez, MI; Grabenstatter, HL; Hund, D; Longo, FM; Raol, YH; Russek, SJ; White, AM; Yang, T, 2014) |
| " The purpose of our study was to investigate whether a physical exercise program applied during brain development could influence the hippocampal plasticity of rats submitted to status epilepticus (SE) induced by pilocarpine model at two different ages of the postnatal period." | 3.80 | Beneficial influence of physical exercise following status epilepticus in the immature brain of rats. ( Arida, RM; Cavalheiro, EA; Gomes Da Silva, S; Gomes, FG, 2014) |
| "The lithium-pilocarpine model is a rat model of epilepsy that mimics status epilepticus in humans." | 3.80 | Dynamics of hippocampal acetylcholine release during lithium-pilocarpine-induced status epilepticus in rats. ( Hillert, MH; Imran, I; Klein, J; Lau, H; Weinfurter, S; Zimmermann, M, 2014) |
| "We have previously reported that an episode of pentylenetetrazole (PTZ)-induced status epilepticus (SE) in immature rats induces a long-term increase in cholinergic excitation assessed in the adult brain in vitro." | 3.80 | A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way. ( Kouis, P; Mikroulis, A; Psarropoulou, C, 2014) |
| " Activity of Na(+),K(+)-ATPase decreased in the hippocampus of C57BL/6 mice 60 days after pilocarpine-induced status epilepticus (SE)." | 3.80 | Long-term decrease in Na+,K+-ATPase activity after pilocarpine-induced status epilepticus is associated with nitration of its alpha subunit. ( de Oliveira, CV; Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, MS; Pereira, LM; Ribeiro, LR; Royes, LF, 2014) |
| "Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin." | 3.80 | Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus. ( Argaãaraz, GA; Cavalheiro, EA; Graça Naffah-Mazzacoratti, Md; Perosa, SR; Silva, JA; Vieira, MJ, 2014) |
| " To analyse early processes in epileptogenesis we used the juvenile pilocarpine model to study status epilepticus (SE)-induced changes in expression of key components in the glutamate-glutamine cycle, known to be affected in MTS patients." | 3.80 | Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats. ( Bos, IW; de Graan, PN; Hessel, EV; Mulder, SD; van der Hel, WS; van Eijsden, P; Verlinde, SA, 2014) |
| "We pretreated mice with MG before seizure induction with picrotoxin or pilocarpine and then assessed seizures behaviorally or by electroencephalography (EEG)." | 3.79 | Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility. ( Distler, MG; Escayg, A; Gorfinkle, N; Palmer, AA; Papale, LA; Termini, J; Winawer, MR; Wuenschell, GE, 2013) |
| "2, the expression of these subunits in hippocampus of five groups of mice with pilocarpine-induced status epilepticus (SE) was evaluated." | 3.79 | The antiepileptic effect of the glycolytic inhibitor 2-deoxy-D-glucose is mediated by upregulation of K(ATP) channel subunits Kir6.1 and Kir6.2. ( Guo, R; Huang, L; Huang, X; Liu, D; Liu, W; Peng, Y; Song, Z; Wu, J; Xie, D; Yang, H; Zheng, W, 2013) |
| "Levetiracetam has been reported to be well tolerated and effective in status epilepticus (SE) refractory to benzodiazepine." | 3.79 | The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus. ( Choi, HC; Kang, TC; Kim, JE; Kim, YI; Lee, DS; Ryu, HJ; Song, HK, 2013) |
| "Administration of carisbamate during status epilepticus (SE) prevents the occurrence of motor seizures in the lithium-pilocarpine model and leads in a subpopulation of rats to spike-and-wave discharges characteristic of absence epilepsy." | 3.79 | A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus. ( Akimana, G; Carneiro, JE; Cassel, JC; Cosquer, B; Faure, JB; Ferrandon, A; Geiger, K; Koning, E; Nehlig, A; Penazzi, L, 2013) |
| " We next used 2 models presenting with increased BBB permeability, hypoxia/reoxygenation and pilocarpine-induced status epilepticus, to assess the response of VWF(-/-) animals." | 3.79 | Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice. ( Brill, A; Cabral, JE; Cifuni, SM; De Meyer, SF; Suidan, GL; Voorhees, JR; Wagner, DD, 2013) |
| " The present paper is the continuation of our previous study which has shown an increased occurrence of creatine inclusions in rat hippocampal formations from the acute phase of pilocarpine-induced status epilepticus (SE) and positive correlation between their quantity and the total time of seizure activity within the observation period." | 3.79 | Differences in the hippocampal frequency of creatine inclusions between the acute and latent phases of pilocarpine model defined using synchrotron radiation-based FTIR microspectroscopy. ( Chwiej, J; Dumas, P; Janeczko, K; Kutorasinska, J; Sandt, C; Setkowicz, Z, 2013) |
| "Experiments were conducted to evaluate the effects of transcranial focal electrical stimulation (TFS) applied via tripolar concentric ring electrodes, alone and associated with a sub-effective dose of diazepam (DZP) on the expression of status epilepticus (SE) induced by lithium-pilocarpine (LP) and subsequent neuronal damage in the hippocampus." | 3.79 | Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats. ( Besio, W; Cuellar-Herrera, M; Luna-Munguia, H; Orozco-Suárez, S; Rocha, L, 2013) |
| " Here we report that both protein and mRNA levels of cortical and hippocampal PGRN are significantly enhanced following pilocarpine-induced status epilepticus." | 3.79 | Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. ( Chang, Q; Cynader, MS; Dong, Z; Jia, W; Leavitt, BR; Liao, C; MacVicar, BA; Petkau, TL; Tai, C; Tian Wang, Y; Wen, W; Zhang, S; Zhu, S, 2013) |
| " The present study used the lithium pilocarpine model of acquired epilepsy in immature animals to assess which structures outside the hippocampus are injured acutely after status epilepticus." | 3.79 | Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat. ( Dudek, FE; Ekstrand, JJ; Scholl, EA, 2013) |
| " In the present study, the PPARγ agonist rosiglitazone inhibited increases in BDNF and TrkB after status epilepticus (SE), and also prevented hippocampal neuronal loss." | 3.79 | The PPARγ agonist rosiglitazone prevents neuronal loss and attenuates development of spontaneous recurrent seizures through BDNF/TrkB signaling following pilocarpine-induced status epilepticus. ( GuiLian, Z; HaiQin, W; Hong, S; HuQing, W; Li, Y; Ning, B; Ru, Z; ShuQin, Z; Xin, Y; YongNan, L, 2013) |
| "6 (SCN8A) and its adapter protein ankyrin G in the AIS of the hippocampal cornu ammonis 3 (CA3) pyramidal cells of rat after status epilepticus induced by lithium-pilocarpine (PISE)." | 3.79 | Plasticity at axon initial segment of hippocampal CA3 neurons in rat after status epilepticus induced by lithium-pilocarpine. ( Feng, L; Li, AP; Long, LL; Sun, DN; Wang, MP; Wang, YL; Xiao, B, 2013) |
| " NKCC1 or KCC2 expression changes have been demonstrated previously in the hippocampal neurons of mice with pilocarpine-induced status epilepticus (PISE)." | 3.79 | STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy. ( Cai, X; Chen, S; Chen, Y; Chen, Z; Fang, Z; Wang, Q; Yang, L; Zhou, J; Zhou, L, 2013) |
| "The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period." | 3.79 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| " Using an antibody selective to pTrkB in conjunction with confocal microscopy and cellular markers, we determined the cellular and subcellular locale of enhanced pTrkB induced by status epilepticus (SE) evoked by infusion of kainic acid into the amygdala of adult mice." | 3.79 | The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis. ( Helgager, J; Liu, G; McNamara, JO, 2013) |
| " Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P < 0." | 3.79 | Hypoxia markers are expressed in interneurons exposed to recurrent seizures. ( Biagini, G; Gualtieri, F; Longo, D; Marinelli, C; Meletti, S; Nichelli, PF; Pugnaghi, M, 2013) |
| " In the present study, we demonstrate the presence of CD11c-positive DCs in the hippocampus, thalamus and temporal cortex following Li-pilocarpine induced status epilepticus (SE) in rats." | 3.79 | Brain recruitment of dendritic cells following Li-pilocarpine induced status epilepticus in adult rats. ( Jiang, W; Li, XW; Ma, L; Wang, JC; Wang, YG; Yang, F, 2013) |
| "This study aims to establish pilocarpine-induced rat model of status epilepticus (SE), observe the activity of calpain I in the rat hippocampus and the subsequent neuronal death, and explore the relationship between calpain I activity and neuronal death in the hippocampus." | 3.79 | Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model. ( Gao, H; Geng, Z, 2013) |
| "The present study examined whether status epilepticus (SE) induced by LiCl-pilocarpine in immature rats (postnatal day [P]12) interferes with normal development; leads to progressive epileptogenesis, or cognitive decline and to pathology similar to that seen in human temporal lobe epilepsy." | 3.79 | Are morphologic and functional consequences of status epilepticus in infant rats progressive? ( Kubová, H; Mareš, P, 2013) |
| " To better understand microRNA expression changes that might contribute to the development of epilepsy, microRNA arrays were performed on rat hippocampus 4 hours, 48 hours and 3 weeks following an episode of pilocarpine induced status epilepticus." | 3.79 | Changes in microRNA expression in the whole hippocampus and hippocampal synaptoneurosome fraction following pilocarpine induced status epilepticus. ( Porter, BE; Risbud, RM, 2013) |
| " The purpose of this study was to evaluate sexual behavior in female rats submitted to pilocarpine-induced status epilepticus (SE)." | 3.79 | Sexual response in female rats with status epilepticus. ( Alvarenga, TA; Amado, D; Andersen, ML; Cavalheiro, EA; Matos, G; Scorza, FA; Tufik, S, 2013) |
| " We found that in the mouse pilocarpine model of status epilepticus (SE), systemic administration of TG6-10-1 completely recapitulates the effects of conditional ablation of cyclooxygenase-2 from principal forebrain neurons, namely reduced delayed mortality, accelerated recovery from weight loss, reduced brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely." | 3.79 | Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. ( Dingledine, R; Dudek, FE; Ganesh, T; Jiang, J; Pouliot, WA; Quan, Y, 2013) |
| " Here we show that mice with decreased CREB levels (CREB(α∆) mutants) have a ~50% reduction in spontaneous seizures following pilocarpine induced status epilepticus (SE) and require more stimulation to electrically kindle." | 3.78 | Decreased CREB levels suppress epilepsy. ( Blendy, JA; Han, X; Porter, BE; Zhu, X, 2012) |
| " Thus, we hypothesized that rosiglitazone, a PPARγ agonist, would prevent cognitive impairment by inhibiting astrocyte activation and regulating glutathione (GSH) homeostasis after status epilepticus (SE)." | 3.78 | The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus. ( GuiLian, Z; HaiQin, W; Hong, S; HuQing, W; Li, Y; Ru, Z; ShuQin, Z; Xin, Y; Yun, D, 2012) |
| "The pilocarpine-induced status epilepticus (SE) in rodents provides a valuable animal model of temporal lobe epilepsy." | 3.78 | The 27-kDa heat shock protein (HSP27) is a reliable hippocampal marker of full development of pilocarpine-induced status epilepticus. ( Bender, R; Glocker, MO; Kirschstein, T; Köhling, R; Kreutzer, M; Mikkat, S; Mikkat, U; Schulz, R, 2012) |
| " The effects of pilocarpine-induced status epilepticus (SE) and the subsequent spontaneous recurrent eizures on the number of GnRH-positive neurons were studied in adult female mice." | 3.78 | Pilocarpine-induced status epilepticus and subsequent spontaneous seizures: lack of effect on the number of gonadotropin-releasing hormone-positive neurons in a mouse model of temporal lobe epilepsy. ( Dudek, FE; Fawley, JA; Pouliot, WA, 2012) |
| "We investigated the cellular localization and progressive changes of corticotropin releasing factor (CRF) in the mouse hippocampus, during and after pilocarpine induced status epilepticus (PISE) and subsequent epileptogenesis." | 3.78 | Corticotropin releasing factor (CRF) in the hippocampus of the mouse pilocarpine model of status epilepticus. ( Ling, EA; Ma, DL; Tang, FR; Wu, J, 2012) |
| " To measure directly the long-term effects of pilocarpine-induced status epilepticus on vesicular release and recycling in hippocampal mossy fibre presynaptic boutons, we used (i) two-photon imaging of FM1-43 vesicular release in rat hippocampal slices; and (ii) transgenic mice expressing the genetically encoded pH-sensitive fluorescent reporter synaptopHluorin preferentially at glutamatergic synapses." | 3.78 | Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy. ( Garrido-Sanabria, ER; Jones, T; Maglakelidze, G; Otero, R; Pacheco, LF; Partida, C; Romanovicz, D; Skinner, F; Stanton, PK; Thakker, R; Upreti, C; Velíšek, L; Velíšková, J; Zhou, ZY, 2012) |
| "Systemic injection of pilocarpine in rodents induces status epilepticus (SE) and reproduces the main characteristics of temporal lobe epilepsy (TLE)." | 3.78 | Consequences of pilocarpine-induced status epilepticus in immunodeficient mice. ( Coimbra, Rde C; Fernandes, MJ; Massironi, SG; Mazzacoratti, Mda G; Nehlig, A; Neto, EF; Persike, DS; Silva, IR; Vignoli, T, 2012) |
| " The present study evaluated the effects of sleep deprivation on locomotor activity and genetic damage in the brains of rats treated with saline or pilocarpine-induced status epilepticus (SE)." | 3.78 | Behavioral and genetic effects promoted by sleep deprivation in rats submitted to pilocarpine-induced status epilepticus. ( Alvarenga, TA; Andersen, ML; Cavalheiro, EA; Hirotsu, C; Le Sueur-Maluf, L; Matos, G; Noguti, J; Ribeiro, DA; Scorza, FA; Tufik, S, 2012) |
| "5-2 fold increase in EAAT2 protein levels as compared to their non-transgenic counterparts, were tested in a pilocarpine-induced status epilepticus (SE) model." | 3.78 | Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus. ( Kong, Q; Lin, CL; Lin, Y; Schulte, D; Stouffer, N; Takahashi, K, 2012) |
| " Following pilocarpine-induced status epilepticus (SE), experimental animals not only developed spontaneous recurrent seizures, but also exhibited significantly elevated levels of aggressive behavior." | 3.78 | Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy. ( Huang, X; Huang, Y; McMahon, J, 2012) |
| " In the present work, we investigated whether pilocarpine-induced status epilepticus (SE) would alter Homer1a and mGluR5 expression in hippocampus." | 3.78 | Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression. ( Blanco, MM; Cavarsan, CF; Mello, LE; Morais, RL; Motta, FL; Tescarollo, F; Tesone-Coelho, C, 2012) |
| "Status epilepticus (SE) induced by pilocarpine or kainate is associated with yet not systemically investigated astrocytic and vascular injuries." | 3.78 | Increased perivascular laminin predicts damage to astrocytes in CA3 and piriform cortex following chemoconvulsive treatments. ( Biagini, G; Curia, G; Gualtieri, F; Marinelli, C, 2012) |
| " The pilocarpine model in rodents reproduces the main features of mesial temporal lobe epilepsy related to hippocampus sclerosis (MTLE-HS) in humans." | 3.78 | Time-dependent modulation of mitogen activated protein kinases and AKT in rat hippocampus and cortex in the pilocarpine model of epilepsy. ( de Cordova, FM; de Mello, N; Leal, RB; Lopes, MW; Nunes, JC; Soares, FM; Walz, R, 2012) |
| "Experimental TLE was triggered by pilocarpine- or kainic acid-induced status epilepticus (SE)." | 3.78 | Changes in interictal spike features precede the onset of temporal lobe epilepsy. ( Bartolomei, F; Bernard, C; Chauvière, L; Doublet, T; Ghestem, A; Huys, R; Jirsa, V; Siyoucef, SS; Wendling, F, 2012) |
| "The present study investigated the effects of phytol in pilocarpine-induced seizures." | 3.78 | Anticonvulsant effect of phytol in a pilocarpine model in mice. ( Costa, JP; De Sousa, DP; Ferreira, PB; Freitas, RM; Jordan, J, 2012) |
| " Pilocarpine-induced status epilepticus animal model was taken as our researching material." | 3.78 | Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. ( Chen, IC; Jaw, T; Lee, CY; Liou, HH; Tseng, HC, 2012) |
| " Here, we examined the anti-epileptogenic effect and possible mechanisms of aspirin, a non-selective Cyclooxygenase (COX) inhibitor, in a rat model of lithium-pilocarpine-induced status epilepticus (SE)." | 3.78 | Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats. ( Cui, XL; Jiang, W; Li, XW; Ma, L; Wang, Y; Wei, D; Yang, F, 2012) |
| "Status epilepticus (SE), a pro-epileptogenic brain insult in rodent models of temporal lobe epilepsy, is successfully induced by pilocarpine in some, but not all, rats." | 3.78 | Hippocampal desynchronization of functional connectivity prior to the onset of status epilepticus in pilocarpine-treated rats. ( Chen, MT; Hung, CP; Lin, YY; Shih, YH; Wang, CH, 2012) |
| "Pilocarpine induces prolonged status epilepticus (SE) in rodents that results in neurodegeneration and cognitive deficits, both commonly observed to be associated with human temporal lobe epilepsy." | 3.78 | Reduction in delayed mortality and subtle improvement in retrograde memory performance in pilocarpine-treated mice with conditional neuronal deletion of cyclooxygenase-2 gene. ( Dingledine, R; Levin, JR; Serrano, G, 2012) |
| "Computer simulations of external current stimulations of dentate gyrus granule cells of rats with Status Epilepticus induced by pilocarpine and control rats were used to evaluate whether morphological differences alone between these cells have an impact on their electrophysiological behavior." | 3.78 | Morphological alterations in newly born dentate gyrus granule cells that emerge after status epilepticus contribute to make them less excitable. ( Arisi, GM; García-Cairasco, N; Roque, AC; Tejada, J, 2012) |
| " During and after pilocarpine induced status epilepticus (SE), a down-regulated expression of CCL28 in hippocampal interneurons in the CA1 area and in the hilus of the dentate gyrus was demonstrated." | 3.78 | CCL28 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus. ( Cao, X; Liu, JX; Liu, Y; Tang, FR, 2012) |
| "The lithium-pilocarpine-induced status epilepticus model and the temporal lobe epilepsy model were established in Sprague-Dawley rats." | 3.78 | MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus. ( Feng, L; Hu, K; Li, Y; Long, HY; Long, LL; Ouyang, DS; Sun, DN; Xiao, B; Xie, YY; Zhang, C, 2012) |
| " Here, we tested the hypothesis that increased levels of the stress-associated hormone corticosterone (CORT) would increase epileptiform activity and spontaneous seizure frequency in mice rendered epileptic following pilocarpine-induced status epilepticus." | 3.78 | Impact of corticosterone treatment on spontaneous seizure frequency and epileptiform activity in mice with chronic epilepsy. ( Batie, M; Castro, OW; Danzer, SC; Garcia-Cairasco, N; Gardner, M; Herman, JP; Holland, KD; McKlveen, JM; Pun, RY; Santos, VR, 2012) |
| " In the study, one of the status epilepticus animal models of epilepsy was used, namely the model of temporal lobe epilepsy with pilocarpine-induced seizures." | 3.78 | Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy--an X-ray fluorescence microscopy study. ( Appel, K; Chwiej, J; Gzielo-Jurek, K; Janeczko, K; Kutorasinska, J; Setkowicz, Z; Simon, R; Uram, L, 2012) |
| "Pilocarpine injection induces epileptic seizures in rodents, an experimental paradigm extensively used to model temporal lobe epilepsy in humans." | 3.78 | Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin-1. ( Barde, YA; Bischoff, V; Deogracias, R; Poirier, F, 2012) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 3.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| " Here, we describe a real time quantitative PCR (qPCR) approach to investigate relative changes in the expression of STREX and ZERO splice variants using a newly designed set of probes and primers for TaqMan-based qPCR analysis of cDNA from the rat dentate gyrus at different time points following pilocarpine-induced status epilepticus." | 3.77 | Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy. ( Arshadmansab, MF; Ermolinsky, BS; Garcia, I; Garrido-Sanabria, ER; Otalora, LF; Skinner, F; Zarei, MM, 2011) |
| "The expression pattern of a global set of Hsps in the adult rat cerebral cortex was examined during the first week following pilocarpine-induced status epilepticus (SE)." | 3.77 | Induction of heat shock proteins in the adult rat cerebral cortex following pilocarpine-induced status epilepticus. ( Brown, IR; Lively, S, 2011) |
| " In the widely used pilocarpine-status epilepticus (SE) rat model of temporal lobe epilepsy (TLE), a major alteration is the marked increase in the fraction of intrinsically bursting CA1 pyramidal cells." | 3.77 | An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus. ( Beck, H; Chen, S; Opitz, T; Remy, S; Royeck, M; Sochivko, D; Su, H; Yaari, Y; Yue, C, 2011) |
| "We analyzed corticostriatal long-term potentiation (LTP) in brain slices of pilocarpine-treated rats after status epilepticus (SE)." | 3.77 | Altered physiology and pharmacology in the corticostriatal system in a model of temporal lobe epilepsy. ( Avchalumov, Y; Kirschstein, T; Köhling, R, 2011) |
| "The aims of this study were to characterize the spatial distribution of neurodegeneration after status epilepticus (SE) induced by either systemic (S) or intrahippocampal (H) injection of pilocarpine (PILO), two models of temporal lobe epilepsy (TLE), using FluoroJade (FJ) histochemistry, and to evaluate the kinetics of FJ staining in the H-PILO model." | 3.77 | Comparative neuroanatomical and temporal characterization of FluoroJade-positive neurodegeneration after status epilepticus induced by systemic and intrahippocampal pilocarpine in Wistar rats. ( Castro, OW; Fernandes, A; Furtado, MA; Garcia-Cairasco, N; Pajolla, GP; Tilelli, CQ, 2011) |
| " Therefore, the present study investigated the temporal pattern of KLF6 expression in the mouse hippocampus and identified cell types expressing KLF6 after pilocarpine-induced status epilepticus (SE)." | 3.77 | Upregulation of Krüppel-like factor 6 in the mouse hippocampus after pilocarpine-induced status epilepticus. ( Cho, KO; Jeong, KH; Kim, SY; Lee, KE, 2011) |
| "Recently, we demonstrated that mRNA for the neuronal glutamate transporter, excitatory amino acid carrier 1 (EAAC1), is found in dendrites of hippocampal neurons in culture and in dendrites of hippocampal pyramidal cells after pilocarpine-induced status epilepticus (SE)." | 3.77 | Group I mGluR-regulated translation of the neuronal glutamate transporter, excitatory amino acid carrier 1. ( Porter, BE; Ramakrishnan, H; Robinson, MB; Ross, JR, 2011) |
| "After pilocarpine-induced status epilepticus, many granule cells born into the postseizure environment migrate aberrantly into the dentate hilus." | 3.77 | Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy. ( Cameron, MC; Nadler, JV; Zhan, RZ, 2011) |
| " We induced cortical malformations by exposing rats prenatally to methylazoxymethanol acetate and triggered status epilepticus and recurrent seizures in adult methylazoxymethanol acetate rats with pilocarpine." | 3.77 | Status epilepticus-induced pathologic plasticity in a rat model of focal cortical dysplasia. ( Balosso, S; Battaglia, G; Carriero, G; Colciaghi, F; Finardi, A; Frasca, A; Locatelli, D; Nobili, P; Vezzani, A, 2011) |
| "We investigated the protein expression of different protein kinase C (PKC) isoforms (PKC-alpha, PKC-beta1, PKC-beta2, PKC-gamma, PKC-delta, PKC-epsilon, PKC-eta and PKC-zeta) in the hippocampus of normal control mice and progressive changes in PKC isoforms expression during and after pilocarpine induced status epilepticus (PISE)." | 3.77 | Pilocarpine-induced status epilepticus alters hippocampal PKC expression in mice. ( Liu, JX; Liu, Y; Tang, FR, 2011) |
| "Pilocarpine-induced status epilepticus (SE) results in chronic spontaneous recurrent seizures resembling human temporal lobe epilepsy." | 3.77 | Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm. ( Bajorat, R; Kirschstein, T; Köhling, R; Sellmann, T; Wilde, M, 2011) |
| " Prolonged seizures (status epilepticus, SE) were induced by pilocarpine." | 3.77 | Seizure-induced structural and functional changes in the rat hippocampal formation: comparison between brief seizures and status epilepticus. ( Cardoso, A; Lukoyanov, NV; Lukoyanova, EA; Madeira, MD, 2011) |
| "Status epilepticus was induced by systemic pilocarpine treatment in green fluorescent protein (GFP)-expressing inhibitory nerurons (GIN) mice in which a subset of somatostatin interneurons expresses GFP." | 3.77 | Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Wen, X, 2011) |
| " Using C57BL/6J × A/J chromosome substitution strains (CSS), we previously identified a locus on mouse chromosome 10 (Ch10) conferring susceptibility to pilocarpine, a muscarinic cholinergic agonist that models human temporal lobe epilepsy by inducing initial limbic seizures and status epilepticus (status), followed by hippocampal cell loss and delayed-onset chronic spontaneous limbic seizures." | 3.77 | Mapping a mouse limbic seizure susceptibility locus on chromosome 10. ( Gildersleeve, SS; Palmer, AA; Phillips, AG; Rabinowitz, D; Winawer, MR, 2011) |
| "The main purposes of this study were (1) to describe the whole course of status epilepticus induced by a low dose lithium-pilocarpine model in rats, including depth-EEG from the hippocampus, ECoG from cortex and gross behaviors, and (2) to investigate the possible changes of the intrinsic neural network in the hippocampus during the status epilepticus by model simulation." | 3.77 | Description and computational modeling of the whole course of status epilepticus induced by low dose lithium-pilocarpine in rats. ( Chiang, CC; Ju, MS; Lin, CC, 2011) |
| " In this study we aimed to characterize the anticonvulsive activity of ghrelin and other growth hormone secretagogue receptor 1a (GHSR(1a)) ligands in rats exposed to status epilepticus induced by pilocarpine or kainate." | 3.77 | Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus. ( Biagini, G; Bresciani, E; Coco, S; Gualtieri, F; Locatelli, V; Marinelli, C; Torsello, A; Vezzali, R, 2011) |
| "Chronically epileptic male adult rats in the pilocarpine model of temporal lobe epilepsy (TLE), exhibited gross expansion of abdominal fat mass and significant weight gain several months after induction of status epilepticus (SE) when compared to control rats." | 3.77 | Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. ( Cox, CB; Ermolinsky, BS; Farrell, B; Garrido-Sanabria, ER; Nair, S; Pacheco, LF; Ruiz, N, 2011) |
| "CFV, Fluoro Jade B and c-Fos staining were done at multiple time points after pilocarpine induced status epilepticus." | 3.77 | Neuron activation, degeneration and death in the hippocampus of mice after pilocarpine induced status epilepticus. ( Liu, J; Liu, Y; Tang, F, 2011) |
| "Status epilepticus was induced in the rats by administration of pilocarpine 350 mg/kg i." | 3.77 | Piperine protects epilepsy associated depression: a study on role of monoamines. ( Nayak, S; Pal, A; Sahu, PK; Swain, T, 2011) |
| " A significant loss of total dorsal subicular neurons, particularly calbindin, parvalbumin (PV) and immunopositive interneurons, was found at 2 months after pilocarpine-induced status epilepticus (SE)." | 3.76 | Morpho-physiologic characteristics of dorsal subicular network in mice after pilocarpine-induced status epilepticus. ( Bragin, A; Engel, J; He, DF; Ma, DL; Tang, FR; Tang, YC, 2010) |
| "Pilocarpine (PC), a muscarinic receptor agonist, is used for the induction of experimental models of status epilepticus (SE) for studying the type of seizure-induced brain injury and other neuropathophysiological mechanisms of related disorder." | 3.76 | The effects of pilocarpine-induced status epilepticus on oxidative stress/damage in developing animals. ( Chang, CN; Chang, SJ; Tsai, HL, 2010) |
| "Chronic epilepsy was elicited after status epilepticus (SE) induced by lithium-pilocarpine in adult Wistar rats." | 3.76 | Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine. ( Guo, Y; Jiang, L, 2010) |
| " The pattern of SC1 localization was not disrupted following hyperthermia or pilocarpine-induced status epilepticus." | 3.76 | The extracellular matrix protein SC1/Hevin localizes to multivesicular bodies in Bergmann glial fibers in the adult rat cerebellum. ( Brown, IR; Lively, S, 2010) |
| " We studied the buspirone effects on oxidative stress in rat hippocampus after seizures and status epilepticus (SE) induced by pilocarpine." | 3.76 | Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone. ( de Freitas, RL; de Freitas, RM; de Souza, GF; Saldanha, GB; Santos, IM; Tomé, Ada R, 2010) |
| "2 at acute and chronic stages during and after pilocarpine-induced status epilepticus (PISE), in order to find out the roles it may play in epileptogenesis." | 3.76 | Nuclear localization of Ca(v)2.2 and its distribution in the mouse central nervous system, and changes in the hippocampus during and after pilocarpine-induced status epilepticus. ( Hu, HT; Long, L; Soong, TW; Tang, FR; Tang, YC; Wang, J; Xu, JH, 2010) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 3.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " We examined whether pharmacological blockade of hippocampal interleukin-1 receptor exerts antidepressant effects in an animal model of comorbidity between TLE and depression, which developed in Wistar rats following pilocarpine status epilepticus (SE)." | 3.76 | Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta. ( Mazarati, AM; Pineda, E; Sankar, R; Shin, D; Taylor, AN; Tio, D, 2010) |
| " We induced status epilepticus (SE) with pilocarpine in adult rats, and investigated endothelial cell proliferation (BrdU and rat endothelial cell antigen-1 (RECA-1) double-labeling), vessel length (unbiased stereology), thrombocyte aggregation (thrombocyte immunostaining), neurodegeneration (Nissl staining), neurogenesis (doublecortin (DCX) immunohistochemistry), and mossy fiber sprouting (Timm staining) in the hippocampus at different time points post-SE." | 3.76 | Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. ( Gröhn, O; Hayward, N; Ndode-Ekane, XE; Pitkänen, A, 2010) |
| "In this study we investigated the effectiveness of two antiepileptic drugs: riluzole and topiramate against pilocarpine-induced seizures, which are considered to be a model of intractable epilepsy commonly used to investigate the antiepileptic effect of drugs and mechanisms of epileptogenesis." | 3.76 | Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats. ( Brzana, W; Czuczwar, M; Kiś, J; Nieoczym, D; Turski, WA; Wlaź, P; Zgrajka, W, 2010) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 3.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| " To better define the role of increased homocysteine in epilepsy, we analyzed the effects of homocysteine pretreatment in the pilocarpine model of status epilepticus (SE), which is used to mimic temporal lobe epilepsy (TLE) in rodents." | 3.76 | Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment. ( Agnati, LF; Andreoli, N; Baldelli, E; Biagini, G; Fuxe, K; Leo, G, 2010) |
| " Stereological techniques were used to estimate numbers of gephyrin-positive punctae in the dentate gyrus, which were reduced short-term (5 days after pilocarpine-induced status epilepticus) but later rebounded beyond controls in epileptic rats." | 3.76 | Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy. ( Buckmaster, PS; Phanwar, I; Thind, KK; Wen, X; Yamawaki, R; Zhang, G, 2010) |
| " In focusing on the role of the DNA repair pathway, we determined the response of the mitochondrial base excision repair (mtBER) pathway in pilocarpine-induced status epilepticus (SE) in hippocampi of male Wistar rats." | 3.76 | Mitochondrial base excision repair pathway failed to respond to status epilepticus induced by pilocarpine. ( Cao, L; Chi, Z; Gao, J; Han, Y; Jiang, H; Lin, Y; Xie, N; Xu, J; Zhao, X, 2010) |
| " Brain injury was launched by status epilepticus induced by intraperitoneal injection of either kainic acid or pilocarpine." | 3.76 | Diffusion tensor MRI of axonal plasticity in the rat hippocampus. ( Gröhn, O; Laitinen, T; Pitkänen, A; Sierra, A, 2010) |
| "To explore the mechanism underlying the development of learning deficits in patients with epilepsy, we generated a mouse model for temporal lobe epilepsy by intraperitoneally injecting mice with pilocarpine with lithium chloride, and investigated time-dependent changes in both contextual fear memory of those model mice and long-term potentiation (LTP) in hippocampal CA1 neurons 1 day, 2 weeks, and 6 weeks after the onset of status epilepticus (SE)." | 3.76 | Time-dependent changes in learning ability and induction of long-term potentiation in the lithium-pilocarpine-induced epileptic mouse model. ( Cai, GE; Ju, G; Li, ST; Lu, QC; Yang, Q; Zhang, Y, 2010) |
| " We investigate whether microinjections of GABAergic agonists into the AN were protective against pilocarpine-induced generalized seizures and status epilepticus (SE)." | 3.76 | Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus. ( Andrade, D; Bittencourt, S; Covolan, L; Dubiela, FP; Hamani, C; Lozano, A; Mello, LE; Queiroz, C, 2010) |
| " A pilocarpine-induced status epilepticus mouse model of TLE was used to study the effect of cannabinoid agonists on recurrent excitatory circuits of the dentate gyrus using electrophysiological recordings in hippocampal slices isolated from control mice and mice with TLE." | 3.76 | Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. ( Bhaskaran, MD; Smith, BN, 2010) |
| " Pilocarpine was administered to induce status epilepticus." | 3.76 | Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus. ( Choy, M; Gadian, DG; Lythgoe, MF; Scott, RC; Thomas, DL; Wells, JA, 2010) |
| " Consistent with our in vitro studies, induction of status epilepticus (SE) in mice using pilocarpine, a mAChR agonist, induces large deficits in the cell surface stability of KCC2 together with enhanced tyrosine phosphorylation." | 3.76 | Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. ( Jurd, R; Lee, HH; Moss, SJ, 2010) |
| " We established that animals that had been subjected to lithium chloride and pilocarpine status epilepticus (SE) and developed spontaneous recurrent seizures, exhibited a set of impairments congruent with a depressive state: behavioral equivalents of anhedonia and despair, dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis, and compromised raphe-hippocampal serotonergic transmission." | 3.76 | Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms. ( Mazarati, AM; Pineda, E; Sankar, R; Shin, D, 2010) |
| "To investigate the localization and progressive changes of cyclic-AMP dependent protein kinase (cPKA) in the mouse hippocampus at acute stages during and after pilocarpine induced status epilepticus." | 3.76 | Status epilepticus alters hippocampal PKAbeta and PKAgamma expression in mice. ( Liu, JX; Liu, Y; Tang, FR; Tang, YC, 2010) |
| " In the rat Li-pilocarpine status epilepticus model, CYM2503, injected intraperitoneally, increased the latency to first electrographic seizure and the latency to first stage 3 behavioral seizure, decreased the latency to the establishment of status epilepticus, and dramatically decreased the mortality." | 3.76 | GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. ( Baldwin, R; Bartfai, T; Chang, J; Liu, T; Lu, X; Roberts, E; Sanchez-Alavez, M; Wasterlain, CG; Wu, S; Xia, F, 2010) |
| "We analyzed with EEG-video monitoring the epileptic activity recorded during the latent and chronic periods in rats undergoing 30 or 120 min pilocarpine-induced convulsive status epilepticus (SE)." | 3.76 | Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system. ( Avoli, M; Biagini, G; Bortel, A; Gotman, J; Lévesque, M, 2010) |
| " We previously reported that endogenous VEGF protein is dramatically upregulated after pilocarpine-induced status epilepticus in the rat, and that intra-hippocampal infusions of recombinant human VEGF significantly protected against the loss of hippocampal CA1 neurons in this model (Nicoletti JN, Shah SK, McCloskey DP, et al." | 3.76 | Vascular endothelial growth factor attenuates status epilepticus-induced behavioral impairments in rats. ( Betancourth, D; Croll, SD; Elkady, A; Khalid, S; Lenzer, J; Nicoletti, JN; Quinteros, D; Rotella, F; Salerni, EA; Shah, SK, 2010) |
| "In the present study we analyzed aquaporin-4 (AQP4) immunoreactivity in the piriform cortex (PC) and the hippocampus of pilocarpine-induced rat epilepsy model to elucidate the roles of AQP4 in brain edema following status epilepticus (SE)." | 3.76 | Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. ( Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, MJ; Ryu, HJ; Yeo, SI, 2010) |
| "Status epilepticus (SE) was induced by pilocarpine in rats that were intracerebroventricularly infused with either saline, 2',3'-O-(4-benzoylbenzoyl)-adenosine 5'-triphosphate (BzATP), adenosine 5'-triphosphate-2',3'-dialdehyde (OxATP), or IL-1Ra (interleukin 1 receptor antagonist) prior to SE induction." | 3.76 | P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus. ( Kang, TC; Kim, JE; Ryu, HJ; Yeo, SI, 2010) |
| "Experimental status epilepticus (SE) was induced using a lithium-pilocarpine injection." | 3.75 | Region-specific plasticity in the epileptic rat brain: a hippocampal and extrahippocampal analysis. ( Chu, K; Jung, KH; Kang, KM; Kim, JH; Kim, M; Kim, SJ; Lee, SK; Lee, ST; Park, HK; Roh, JK; Song, EC, 2009) |
| " Chi, Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus." | 3.75 | Participation of mu-calpain in status epilepticus-induced hippocampal injury. ( Lopez-Meraz, ML; Niquet, J, 2009) |
| " To address this issue, we examined the behavioral sequelae of repeated brief seizures evoked by electroconvulsive shock (ECS) and compared them with those resulting from prolonged status epilepticus (SE) induced with pilocarpine." | 3.75 | Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat. ( Cardoso, A; Carvalho, LS; Lukoyanov, NV; Lukoyanova, EA, 2009) |
| " We sought to determine which cells express P450cc and whether neurosteroids play a role in the regulation of epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 3.75 | Neurosteroids and epileptogenesis in the pilocarpine model: evidence for a relationship between P450scc induction and length of the latent period. ( Avoli, M; Baldelli, E; Bertazzoni, G; Biagini, G; Longo, D; Rogawski, MA; Zoli, M, 2009) |
| " We found that rats previously subjected to lithium-pilocarpine (LiPC)-induced neonatal status epilepticus (NeoSE) exhibited enhanced behavioral sensitization to methamphetamine (MA) in adolescence." | 3.75 | Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence. ( Chen, GS; Huang, LT; Huang, YN; Lin, TC; Wang, JY, 2009) |
| " Here we investigated the alterations of the two alpha-subunits SCN8A and SCN1A and their adapter ankyrin-G in the hippocampal cornu ammonis 1 (CA1) of rats after pilocarpine induced status epilepticus (PISE), compared to the sham-control group (C1) and blank-control group (C2)." | 3.75 | Long-term increasing co-localization of SCN8A and ankyrin-G in rat hippocampal cornu ammonis 1 after pilocarpine induced status epilepticus. ( Chen, L; Chen, S; Chen, Z; Dai, Q; Li, X; Yang, L; Zhou, J; Zhou, L, 2009) |
| " Inflammation, angiogenesis and BBB permeability were studied in postnatal day (PN)9 and PN21 rats, 1 week and 4 months after pilocarpine-induced status epilepticus." | 3.75 | Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis. ( Balosso, S; Gagliardi, B; Lerner-Natoli, M; Marcon, J; Maroso, M; Morin, M; Noé, F; Ravizza, T; Vezzani, A, 2009) |
| " To determine if a single event of status epilepticus and its latent consequences can affect motor map expression, we assessed forelimb motor maps in rats using the pilocarpine model of temporal lobe epilepsy." | 3.75 | Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain. ( Flynn, C; Ozen, LJ; Teskey, GC; Vuong, J; Young, NA, 2009) |
| " Our laboratory recently characterized a novel plasticity change of the cannabinoid type 1 (CB(1)) receptor in hippocampi of epileptic rats following pilocarpine-induced status epilepticus (SE)." | 3.75 | Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Falenski, KW; Harrison, AJ; Martin, BR, 2009) |
| "Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus." | 3.75 | Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus. ( Cunha, AO; dos Santos, WF; Liberato, JL; Mortari, MR, 2009) |
| "To investigate the activation pattern of extracellular signal-regulated kinase 1/2 (ERK1/2) in the hippocampus of mice during pilocarpine-induced status epilepticus (SE) and its relationship with reactive astrogliosis." | 3.75 | ERK1/2 activation in reactive astrocytes of mice with pilocarpine-induced status epilepticus. ( Chen, YM; Li, YQ; Liu, H; Xu, J; Xu, ZC; Xue, T, 2009) |
| "Lithium-pilocarpine induced status epilepticus (LPSE) causes selective and age-dependent neuronal death, although the mechanism of maturation-related injury has not yet been clarified." | 3.75 | Differential expression of activating transcription factor-2 and c-Jun in the immature and adult rat hippocampus following lithium-pilocarpine induced status epilepticus. ( Han, SR; Kim, YI; Park, J; Park, S; Rhyu, S; Shin, C, 2009) |
| " The muscarinic convulsant pilocarpine was used to elicit status epilepticus (SE) in adult female Sprague Dawley rats." | 3.75 | A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures. ( Friedman, D; Harden, CL; Maclusky, NJ; Malthankar-Phatak, GH; McCloskey, DP; Pearce, P; Scharfman, HE, 2009) |
| " Whole cell patch-clamp recordings were made from normotopic granule cells in hippocampal slices from control rats and from both normotopic and hilar ectopic granule cells in slices from rats subjected to pilocarpine-induced status epilepticus." | 3.75 | Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus. ( Nadler, JV; Zhan, RZ, 2009) |
| "To investigate protein and gene expressions of chemokine subtypes CCR3, CCR2A and their respective ligands macrophage inflammatory protein 1-alpha (MIP-1alpha), monocyte chemotactic protein-1 (MCP-1) in the normal mouse central nervous system (CNS) and in the hippocampus at different time points during and after pilocarpine-induced status epilepticus (PISE)." | 3.75 | CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE) . ( Hut, HT; Long, L; Tang, FR; Tang, YC; Xu, JH; Zhang, JT, 2009) |
| " In the rat pilocarpine model, status epilepticus significantly increased P-glycoprotein expression by 92 to 197% in the hippocampal hilus and granule cell layer as well as the piriform cortex." | 3.75 | Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation. ( Bauer, B; Gorter, JA; Hartz, AM; Pekcec, A; Potschka, H; Schlichtiger, J; Soerensen, J; Unkrüer, B; van Vliet, EA, 2009) |
| " The ventral limbic region (VLR) in the rat brain was used because we determined that its neurons express minimal EpoR under basal conditions, and they are highly sensitive to excitotoxic damage, such as occurs with pilocarpine-induced status epilepticus (Pilo-SE)." | 3.75 | Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons. ( Baulieu, EE; Belmeguenai, A; Bezin, L; Bodennec, J; Bonnet, C; Bouvard, S; Fares, RP; Georges, B; Le-Cavorsin, M; Levine, RA; Morales, A; Moulin, C; Pequignot, JM; Risso, JJ; Sanchez, PE, 2009) |
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| "Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy." | 3.75 | Does pilocarpine-induced epilepsy in adult rats require status epilepticus? ( Bramanti, P; Chakir, A; Fabene, PF; Marzola, P; Navarro Mora, G; Nicolato, E; Osculati, F; Sbarbati, A, 2009) |
| " Rapamycin was focally, continuously, and unilaterally infused into the dorsal hippocampus for prolonged periods beginning within hours after rats sustained pilocarpine-induced status epilepticus." | 3.75 | Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. ( Buckmaster, PS; Ingram, EA; Wen, X, 2009) |
| " The main purpose of this study was to determine whether other ketones, 2-butanone (methyl ethyl ketone: MEK) and 3-pentanone (diethyl ketone: DEK), also show anticonvulsive effects in lithium-pilocarpine (Li-pilocarpine)-induced status epilepticus (SE) in rats." | 3.75 | Methyl ethyl ketone blocks status epilepticus induced by lithium-pilocarpine in rats. ( Abe, K; Gee, A; Hasebe, N; Hosoi, R; Inoue, O; Sugiyama, E; Tsuchiya, N; Yamaguchi, M, 2009) |
| " To determine if there is a window of vulnerability in the developing rat, post-natal day 19 animals were subjected to a severe lateral fluid percussion injury followed by pilocarpine (Pc)-induced status epilepticus at 1, 6 or 24 h post TBI." | 3.75 | Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. ( Auvin, S; Giza, CC; Gurkoff, GG; Hovda, DA; Sankar, R; Shin, D, 2009) |
| " The effect of PDTC on status epilepticus-associated cell loss in the hippocampus and piriform cortex was evaluated in the rat fractionated pilocarpine model." | 3.75 | Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model. ( Fuest, C; Nickel, A; Pekcec, A; Potschka, H; Soerensen, J, 2009) |
| " In this work CCR2 and CCL2 expression were examined following status epilepticus (SE) induced by pilocarpine injection." | 3.75 | Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus. ( Arisi, GM; Foresti, ML; Katki, K; Montañez, A; Sanchez, RM; Shapiro, LA, 2009) |
| " In this study, we aimed to investigate the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus (PISE) and their relationship with epileptogenesis." | 3.74 | Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE). ( Chen, S; Chen, Z; Li, X; Zhou, J; Zhou, L; Zhu, F, 2008) |
| " Male Wistar rats were subjected to LiCl and pilocarpine status epilepticus (SE)." | 3.74 | Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. ( Baldwin, RA; Caplan, R; Mazarati, A; Sankar, R; Shin, D; Siddarth, P, 2008) |
| " We studied the activity of caspase-1, -3 and -8 in the hippocampus of rats exhibiting status epilepticus induced by pilocarpine." | 3.74 | Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus. ( Cavalheiro, EA; Cunha, RL; Dona, F; Fernandes, MJ; Juliano, L; Persike, DS; Rosim, FE; Silva, IR; Vignoli, T, 2008) |
| " Here, we investigated seizure-induced changes in mGlu2 and mGlu3 mRNA following pilocarpine-inducted status epilepticus (SE) and subsequent epileptogenesis." | 3.74 | Differential changes in mGlu2 and mGlu3 gene expression following pilocarpine-induced status epilepticus: a comparative real-time PCR analysis. ( Arshadmansab, MF; Ermolinsky, B; Garrido-Sanabria, ER; Pacheco Otalora, LF; Zarei, MM, 2008) |
| " Here, we describe a lesion that destroys the perforant path in CA3 after status epilepticus (SE) induced by pilocarpine injection in 8-week-old rats." | 3.74 | Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. ( Avoli, M; Baldelli, E; Biagini, G; Contri, MB; Gelosa, P; Guerrini, U; Longo, D; Ragsdale, DS; Sironi, L; Zini, I, 2008) |
| " Here, we induced lithium-pilocarpine status epilepticus (SE) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) or in Wistar audiogenic sensitive (AS) rats." | 3.74 | The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats. ( Ferrandon, A; Hanaya, R; Koning, E; Nehlig, A, 2008) |
| "In the present study, we performed an analysis of tandem of P domains in a weak inwardly rectifying K+ channel (TWIK)-related acid-sensitive K+ (TASK)-1 channel immunoreactivity in the rat hippocampal complex following pilocarpine-induced status epilepticus (SE)." | 3.74 | Region-specific alterations in astroglial TWIK-related acid-sensitive K+-1 channel immunoreactivity in the rat hippocampal complex following pilocarpine-induced status epilepticus. ( Choi, SY; Kang, TC; Kim, JE; Kwak, SE, 2008) |
| " Here, we report a long-lasting deficit in gene expression of Kcnma1 coding for the large-conductance calcium-activated potassium (BK, MaxiK) channel alpha-subunits after pilocarpine-induced status epilepticus." | 3.74 | Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats. ( Arshadmansab, MF; Ermolinsky, B; Garrido-Sanabria, ER; Pacheco Otalora, LF; Zarei, MM, 2008) |
| " In the present study the effects of chronic treatment with levetiracetam were assessed in rats that sustained pilocarpine-induced status epilepticus (SE)." | 3.74 | Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats. ( Kaminski, RM; Klitgaard, H; Margineanu, DG; Matagne, A, 2008) |
| " In the present study in mGluR5 wild-type (mGluR5+/+) mice, we showed induced PKCbeta2 or PKCgamma expression at the border between the stratum oriens and alveus (O/A border) at 2h during pilocarpine induced status epilepticus (SE), and in the stratum pyramidale in CA1 area at 1 day after pilocarpine induced SE; at 1 day, induced expression of PLCbeta4 in the stratum pyramidale of CA1 area was observed." | 3.74 | mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice. ( Liu, JX; Liu, Y; Tang, FR; Tang, YC, 2008) |
| "Pilocarpine-induced status epilepticus (SE) mimics many features of temporal lobe epilepsy and is a useful model to study neural changes that result from prolonged seizure activity." | 3.74 | Extracellular matrix protein SC1/hevin in the hippocampus following pilocarpine-induced status epilepticus. ( Brown, IR; Lively, S, 2008) |
| " Animals (n = 14) were administered pilocarpine to induce status epilepticus." | 3.74 | Oral administration of fructose-1,6-diphosphate has anticonvulsant activity. ( Lian, XY; Stringer, JL; Xu, K, 2008) |
| "Recently we reported that astroglial loss and subsequent gliogenesis in the dentate gyrus play a role in epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 3.74 | Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus. ( Choi, KC; Choi, SY; Kang, TC; Kim, DS; Kim, DW; Kim, JE; Kwak, SE; Kwon, OS, 2008) |
| "2 channel and of its major modulator, voltage-dependent potassium channel-interacting protein (KChIP1), is altered following lithium-pilocarpine induced status epilepticus (SE) and the chronic-epilepsy phase in the rat model." | 3.74 | Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus. ( Cong, WD; Deng, WY; Liao, WP; Long, YS; Luo, AH; Su, T; Sun, WW, 2008) |
| "The COX-2 inhibitor celecoxib decreased neuronal excitability and prevented epileptogenesis in pilocarpine-induced status epilepticus rats." | 3.74 | Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats. ( Lei, GF; Liu, CX; Sun, RP; Yang, L; Zhang, HJ, 2008) |
| " Thus, we submitted developing rats to pilocarpine-induced status epilepticus (SE) to study the relationship between neurogenesis and mossy fiber sprouting." | 3.74 | Neurogenesis induced by seizures in the dentate gyrus is not related to mossy fiber sprouting but is age dependent in developing rats. ( Amado, D; Argañaraz, GA; Cavalheiro, EA; Lima, E; Loeb, LM; Naffah-Mazzacoratti, Mda G; Priel, MR; Sanabria, Ydel C; Scorza, FA; Trindade, Eda S, 2008) |
| "Lithium-pilocarpine status epilepticus (SE) resulted in delayed changes of single cortical interhemisperic (transcallosal) responses in immature rats." | 3.74 | Depression and/or potentiation of cortical responses after status epilepticus in immature rats. ( Mares, P; Tsenov, G, 2007) |
| " We have shown recently that topiramate (TPM) dose-dependently protects hippocampal CA1 and CA3 neurons during initial status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibition of mitochondrial transition pore opening." | 3.74 | Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. ( Elger, CE; Frisch, C; Helmstaedter, C; Kudin, AP; Kunz, WS, 2007) |
| "The present study was designed to examine whether neuroprotective agents, FK506 or cyclosporin A (CsA), applied to rats undergoing pilocarpine-induced seizures can minimize further development of the status epilepticus." | 3.74 | Neuroprotectants FK-506 and cyclosporin A ameliorate the course of pilocarpine-induced seizures. ( Ciarach, M; Setkowicz, Z, 2007) |
| " Here, we measured the response of hippocampal Epo system components (Epo, Epo-R and betac) during neurodegenerative processes following pilocarpine-induced status epilepticus (SE), and examined whether recombinant human Epo (rHuEpo) could support neuronal survival." | 3.74 | Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus. ( Bezin, L; Georges, B; Laglaine, A; Morales, A; Moulin, C; Nadam, J; Navarro, F; Pequignot, JM; Ryvlin, P; Sanchez, P, 2007) |
| " During and after pilocarpine-induced status epilepticus, progressive changes of each of CCR7, CCR8, CCR9 and CCR10 proteins occurred in different patterns at various time points." | 3.74 | CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus. ( Cao, X; Liu, JX; Liu, Y; Tang, FR; Tang, YC, 2007) |
| "The effects of repetitive pilocarpine-induced status epilepticus (SE) in the hippocampal Na(+)/K(+)ATPase activity were studied in developing rat." | 3.74 | The Na+/K+ATPase activity is increased in the hippocampus after multiple status epilepticus induced by pilocarpine in developing rats. ( Arida, RM; da Silva Fernandes, MJ; Mara de Oliveira, D; Reime Kinjo, E, 2007) |
| "Lithium-pilocarpine-induced status epilepticus (SE) generates neuronal lesions in the limbic forebrain, cerebral cortex and thalamus that lead to circuit reorganization and spontaneous recurrent seizures." | 3.74 | Dissociation of the immunoreactivity of synaptophysin and GAP-43 during the acute and latent phases of the lithium-pilocarpine model in the immature and adult rat. ( Boehm, N; Hanaya, R; Nehlig, A, 2007) |
| " Neurochemical studies have proposed a role for catalase in brain mechanisms responsible by development to status epilepticus (SE) induced by pilocarpine." | 3.74 | Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats. ( Barbosa, CO; Barros, DO; Freitas, RL; Freitas, RM; Maia, FD; Oliveira, AA; Silva, RF; Takahashi, RN; Xavier, SM, 2007) |
| "We sought to investigate the anticonvulsive and neuroprotective effect of a selective metabotropic glutamate receptor 8 (mGluR8) agonist (S)-3,4-dicarboxyphenylglycines (S-3,4-DCPG) on pilocarpine-induced status epilepticus (PISE) and subsequent loss of hilar neurons in the dentate gyrus after systemic (intravenous) or local (intracerebroventricular) administration." | 3.74 | Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. ( Chia, SC; Jay, TM; Jiang, FL; Tang, FR; Tang, YC, 2007) |
| " In this study, we analyzed the contribution of neuronal necrosis and caspase-3 activation to CA1 damage following lithium-pilocarpine SE in P14 rat pups." | 3.74 | Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain. ( Allen, S; Archie, M; Auvin, S; Niquet, J; Sankar, R; Seo, DW; Wasterlain, CG, 2007) |
| "Pilocarpine administration to rats results in status epilepticus (SE) and after a latency period to the occurrence of spontaneous seizures." | 3.74 | Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat. ( Goffin, K; Nissinen, J; Pitkänen, A; Van Laere, K, 2007) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| " In the present study, we compared the effects of riluzole and valproate (VPA) in the pilocarpine-induced limbic seizure model and in the gamma-hydroxybutyrate lactone (GBL)-induced absence seizure model." | 3.74 | Anti-glutamatergic effect of riluzole: comparison with valproic acid. ( Choi, HC; Choi, SY; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Kwak, SE; Kwon, OS; Song, HK, 2007) |
| " Antioxidant properties have been showed in seizures and status epilepticus (SE) induced by pilocarpine in adult rats." | 3.74 | Vitamin C antioxidant effects in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpine. ( Barbosa, CO; Barros, DO; Freitas, RM; Oliveira, AA; Silva, RF; Xavier, SM, 2007) |
| " The recordings were performed in epileptic rats 24 h after an early behavioural spontaneous seizure between 5 and 21 days after pilocarpine-induced status epilepticus." | 3.74 | Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study. ( Mello, LE; Queiroz, CM, 2007) |
| " Electron microscopic immunolabeling was therefore used to determine if mossy cell axon terminals form synapses with hilar EGC dendrites, using animals that underwent pilocarpine-induced status epilepticus." | 3.74 | Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures. ( McCloskey, DP; Pierce, JP; Punsoni, M; Scharfman, HE, 2007) |
| "A common experimental model of status epilepticus (SE) utilizes intraperitoneal administration of the cholinergic agonist pilocarpine preceded by methyl-scopolamine treatment." | 3.74 | In vivo and in vitro effects of pilocarpine: relevance to ictogenesis. ( Batra, A; De Curtis, M; Hernandez, N; Janigro, D; Marchi, N; Najm, I; Oby, E; Uva, L; Van Boxel-Dezaire, A, 2007) |
| "The aim of this pilot study was to investigate the antiepileptic effects of a novel noninvasive stimulation technique, transcutaneous electrical stimulation (TcES) via scalp concentric ring electrodes, on pilocarpine-induced status epilepticus (SE) in rats." | 3.74 | Effects of noninvasive transcutaneous electrical stimulation via concentric ring electrodes on pilocarpine-induced status epilepticus in rats. ( Besio, WG; Cole, AJ; Koka, K, 2007) |
| "By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200mg/kg), SIB1893 (from 25 to 100mg/kg), MPEP (from 25 to 100mg/kg) injected at 1 or 2h during PISE were ineffective in controlling status epilepticus (SE)." | 3.74 | Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus. ( Chen, PM; Lee, WL; Tang, FR; Tang, YC; Tsai, MC, 2007) |
| " These strains were compared using the chemoconvulsant pilocarpine, because pilocarpine induces status epilepticus, a state of severe, prolonged seizures." | 3.74 | Acute and chronic responses to the convulsant pilocarpine in DBA/2J and A/J mice. ( Hintz, TM; Makarenko, N; McCloskey, DP; Nair, N; Palmer, AA; Scharfman, HE; Winawer, MR, 2007) |
| " Postnatal day 7 (P7) and P14 rat pups were injected with an exogenous provocative agent of inflammation, lipopolysaccharide (LPS), 2 h prior to limbic SE induced by either lithium-pilocarpine (LiPC) or kainic acid." | 3.74 | Inflammation exacerbates seizure-induced injury in the immature brain. ( Auvin, S; Mazarati, A; Miyamoto, J; Nakagawa, J; Sankar, R; Shin, D, 2007) |
| " To study developmental changes of this role LiCl/pilocarpine status epilepticus (SE) was induced in P12, P25 and/or adult rats." | 3.74 | Effects of LiCl/pilocarpine-induced status epilepticus on rat brain mu and benzodiazepine receptor binding: regional and ontogenetic studies. ( Kubová, H; Mares, P; Rocha, L; Suchomelová, L, 2007) |
| "To investigate the effects of olomoucine, a cyclin dependent protein kinase (CDK) inhibitor, on the neuronal apoptosis after status epilepticus (SE)." | 3.74 | [Effects of cyclin dependent protein kinase inhibitor olomoucine on the neuronal apoptosis after status epilepticus: experiment with rats]. ( Chen, HX; Du, XP; Sun, MZ; Tian, DS; Wang, W; Xie, MJ; Yu, ZY, 2007) |
| " In this study, we assessed changes in vascular structure, gene expression, and the time course of neuronal degeneration in the cerebral cortex during the acute period after onset of pilocarpine-induced status epilepticus (SE)." | 3.74 | Pilocarpine-induced status epilepticus in rats involves ischemic and excitotoxic mechanisms. ( Benati, D; Bernardi, P; Fabene, PF; Farace, P; Galiè, M; Marzola, P; Merigo, F; Nicolato, E; Sbarbati, A, 2007) |
| " Because a linear relationship does not always exist between expression of mRNA and protein, we investigated whether VEGF protein expression increased after pilocarpine-induced status epilepticus." | 3.74 | Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. ( Atassi, H; Croll, SD; Elkady, A; Goodman, JH; Hylton, D; McCloskey, DP; Nicoletti, JN; Rudge, JS; Scharfman, HE; Shah, SK, 2008) |
| "The anticonvulsant effects of AN stimulation against pilocarpine-induced seizures were mainly determined by the current and not the frequency of stimulation." | 3.74 | Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus. ( Andrade, DM; Chiang, J; del Campo, M; Hamani, C; Hodaie, M; Lozano, AM; Mello, LE; Mirski, M; Sherman, D, 2008) |
| "This study investigated putative correlations among behavioral changes and: (1) neuronal loss, (2) hippocampal mossy fiber sprouting, and (3) reactive astrogliosis in adult rats submitted to early-life LiCl-pilocarpine-induced status epilepticus (SE)." | 3.74 | Effects of early-life LiCl-pilocarpine-induced status epilepticus on memory and anxiety in adult rats are associated with mossy fiber sprouting and elevated CSF S100B protein. ( da Silva, MC; de Oliveira, DL; e Souza, TM; Fischer, A; Gonçalves, CA; Jorge, RS; Leite, M; Quillfeldt, JA; Souza, DO; Wofchuk, S, 2008) |
| "The neuroprotective effects of pentoxifylline (PTX) against lithium-pilocarpine (Li-Pc)-induced status epilepticus (SE) in young rats are described." | 3.74 | Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats. ( Ahmad, M; Deeb, SA; Moutaery, KA; Tariq, M, 2008) |
| "Partial limbic seizures in rodents induced by pilocarpine progress from stages I-II (mouth and facial movements; head nodding) to stage III (forelimb clonus) and then progress rapidly to stages IV-V (generalized limbic seizures; rearing, and rearing with falling) followed by status epilepticus (SE)." | 3.74 | Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus. ( Feng, HJ; Kao, C; Macdonald, RL; Mathews, GC, 2008) |
| "We determined the efficacy of diazepam (DZP) and pentobarbital (PTB) in controlling prolonged status epilepticus (SE) in developing rats." | 3.74 | Effective treatments of prolonged status epilepticus in developing rats. ( Hasson, H; Kim, M; Moshé, SL, 2008) |
| " A correlative study between diffusion characteristics and the severity of MFS was investigated in the pilocarpine-induced status epilepticus (SE) rat model." | 3.74 | Mossy fiber sprouting in pilocarpine-induced status epilepticus rat hippocampus: a correlative study of diffusion spectrum imaging and histology. ( Chen, CC; Chen, JH; Kuo, LW; Lee, CY; Liou, HH; Tseng, WY; Wedeen, VJ, 2008) |
| " Our study showed that there was an increased CD40 expression on activated microglia in the brain injury after lithium pilocarpine-induced status epilepticus (SE) in rats." | 3.74 | Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. ( Deng, Y; Huang, Y; Li, R; Li, Y; Sun, H; Yang, J; Yu, X; Zhao, G, 2008) |
| "Morphological changes in the hippocampi of rats subjected to lithium-pilocarpine-induced status epilepticus (SE) were examined with respect to neuronal loss, inflammation, blood-brain barrier (BBB) leakage, and cell genesis." | 3.74 | Erythropoietin reduces epileptogenic processes following status epilepticus. ( Chu, K; Jung, KH; Kang, KM; Kim, HK; Kim, JH; Kim, M; Lee, SK; Lee, ST; Lim, JS; Park, HK; Roh, JK, 2008) |
| " The rat lithium-pilocarpine model, which mimics many features of temporal lobe epilepsy, has been used to study processes leading to the development of recurrent seizures." | 3.74 | The extracellular matrix protein SC1/hevin localizes to excitatory synapses following status epilepticus in the rat lithium-pilocarpine seizure model. ( Brown, IR; Lively, S, 2008) |
| "Kainic acid was administered in repeated low doses (5 mg/kg) every hour until each Sprague-Dawley rat experienced convulsive status epilepticus for >3 h." | 3.73 | Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy. ( Chapman, PL; Dudek, FE; Ferraro, DJ; Grabenstatter, HL; Williams, PA, 2005) |
| "Systemic administration of pilocarpine preceded by lithium induces status epilepticus (SE) that results in neurodegeneration and may lead to the development of spontaneous recurrent seizures." | 3.73 | Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus. ( Bissoon, N; Gurd, JW; Ikeda-Douglas, C; Milgram, NW; Moussa, R; Niimura, M, 2005) |
| "The role of oxidative stress in pilocarpine-induced status epilepticus was investigated by measuring lipid peroxidation level, nitrite content, GSH concentration, and superoxide dismutase and catalase activities in the hippocampus of Wistar rats." | 3.73 | Oxidative stress in the hippocampus after pilocarpine-induced status epilepticus in Wistar rats. ( Fonteles, MM; Freitas, RM; Souza, FC; Vasconcelos, SM; Viana, GS, 2005) |
| "Multiple episodes of pilocarpine-induced status epilepticus (SE) in developing rats (P7-P9) lead to progressive epileptiform activity and severe cognitive impairment in adulthood." | 3.73 | Neocortical and hippocampal changes after multiple pilocarpine-induced status epilepticus in rats. ( Cavalheiro, EA; Cipelletti, B; Frassoni, C; Regondi, MC; Silva, AV; Spreafico, R, 2005) |
| "The status epilepticus (SE) induced in rats by lithium-pilocarpine (Li-pilo) shares many common features with soman-induced SE including extensive limbic neuropathology." | 3.73 | Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus. ( Griffith, JW; Peterson, SL; Purvis, RS, 2005) |
| "Significant reduction in glutamate receptor 1 (GluR1)- and GluR2/3-immunopositive neurons was demonstrated in the hilus of the dentate gyrus in mice killed on days 1, 7 and 60 after pilocarpine-induced status epilepticus (PISE)." | 3.73 | Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus. ( Chen, PM; Chia, SC; Gao, H; Khanna, S; Lee, WL; Liu, CP; Tang, FR; Zhang, S, 2005) |
| " We tested this hypothesis by repeatedly assessing granule cell excitability after pilocarpine-induced status epilepticus (SE) and monitoring granule cell behavior during 235 spontaneous seizures in awake, chronically implanted rats." | 3.73 | Hippocampal granule cell activity and c-Fos expression during spontaneous seizures in awake, chronically epileptic, pilocarpine-treated rats: implications for hippocampal epileptogenesis. ( Harvey, BD; Sloviter, RS, 2005) |
| "The aim of the present study was to observe possible cortical abnormalities after repetitive pilocarpine-induced status epilepticus (SE) in rats during development." | 3.73 | Disruption of cortical development as a consequence of repetitive pilocarpine-induced status epilepticus in rats. ( Cavalheiro, EA; da Silva, AV; Regondi, MC; Spreafico, R, 2005) |
| "Lithium-pilocarpine status epilepticus was elicited in 12- (SE12) or 25-day-old (SE25) rats." | 3.73 | Changes of cortical interhemispheric responses after status epilepticus in immature rats. ( Aleksakhina, K; Druga, R; Kubová, H; Mares, P; Tsenov, G, 2005) |
| "To test effects of paraldehyde on behavioral outcome of status epilepticus (SE) in developing rats." | 3.73 | Outcome of status epilepticus in immature rats varies according to the paraldehyde treatment. ( Kubová, H; Mares, P; Redkozubova, O; Rejchrtová, J, 2005) |
| "We describe the use of a clinically relevant pharmacological intervention that alters the clinical history of status epilepticus (SE)-induced spontaneous recurrent seizures (SRS) in the pilocarpine model and the possible plastic changes underlying such an effect." | 3.73 | Plastic changes and disease-modifying effects of scopolamine in the pilocarpine model of epilepsy in rats. ( Benassi, SK; Mello, LE; Pereira, HA, 2005) |
| " To investigate how GAP43 expression (GAP43-ir) correlates with MFS, we assessed the intensity (densitometry) and extension (width) of GAP43-ir in the inner molecular layer of the dentate gyrus (IML) of rats subject to status epilepticus induced by pilocarpine (Pilo), previously injected or not with cycloheximide (CHX), which has been shown to inhibit MFS." | 3.73 | Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide. ( Longo, B; Mello, LE; Vezzani, A, 2005) |
| " The purposes of this study were to characterize the role of adenosine receptors in modulating status epilepticus (SE) induced by pilocarpine and evaluate its neuroprotective action." | 3.73 | Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats. ( Cavalheiro, EA; da Silva Fernandes, MJ; Doná, F; Ferreira, AT; Vianna, EP, 2005) |
| " In the pilocarpine and KA models, doses lower than those used in Wistar rats were able to induce status epilepticus (SE) in PG animals." | 3.73 | Proechimys guyannensis: an animal model of resistance to epilepsy. ( Arida, RM; Cavalheiro, EA; de Amorim Carvalho, R; Scorza, FA, 2005) |
| " After 2 days of infusion, rats were treated with pilocarpine to induce status epilepticus." | 3.73 | Prolonged infusion of cycloheximide does not block mossy fiber sprouting in a model of temporal lobe epilepsy. ( Buckmaster, PS; Toyoda, I, 2005) |
| "To explore the age character of the activity of Caspase 3 and neuron death induced by LiCl-pilocarpine status epilepticus." | 3.73 | [Age difference of the activation of apoptotic cascade reaction following LiCl-pilocarpine status epilepticus]. ( Cai, FC; Cai, XT, 2005) |
| "To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 3.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
| " In the present study, chronically epileptic rats had their brains processed for neo-Timm and acetylcholinesterase two months after the induction of status epilepticus with pilocarpine." | 3.73 | Neo-Timm staining in the thalamus of chronically epileptic rats. ( Hamani, C; Mello, LE; Paulo, Id, 2005) |
| " Rats were assigned randomly to the following five groups: (1) control (CONT) rats; (2) NI rats that underwent daily separation from their dams from postnatal day 2 (P2) to P9; (3) status epilepticus (SE) rats, induced by lithium-pilocarpine (Li-Pilo) model at P10; (4) NI plus SE (NIS) rats and (5) NISM rats, a subset of NIS rats receiving metyrapone (100 mg/kg), a CORT synthesis inhibitor, immediately after SE induction." | 3.73 | Effect of neonatal isolation on outcome following neonatal seizures in rats--the role of corticosterone. ( Holmes, GL; Hsieh, CS; Huang, LT; Lai, MC; Lee, CH; Lee, KH; Tiao, MM; Wang, CA; Wu, CL; Yang, SN, 2006) |
| " In this study, we investigated whether increased generation of FR during status epilepticus would be sufficient to provoke abnormalities in mtDNA and in the expression and activity of cytochrome c oxidase (CCO), complex IV of the respiratory chain, in the chronic phase of the pilocarpine model of temporal lobe epilepsy." | 3.73 | Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine. ( Amado, D; Cavalheiro, EA; Naffah-Mazzacoratti, Mda G; Nasseh, IE; Tengan, CH, 2006) |
| "To further characterize the capacity of lovastatin to prevent hippocampal neuronal loss after pilocarpine-induced status epilepticus (SE) METHOD: Adult male Wistar rats were divided into four groups: (A) control rats, received neither pilocarpine nor lovastatin (n=5); (B) control rats, received just lovastatin (n=5); (C) rats that received just pilocarpine (n=5); (D) rats that received pilocarpine and lovastatin (n=5)." | 3.73 | Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results. ( Arida, RM; Cavalheiro, EA; Colugnati, DB; Cysneiros, RM; de Albuquerque, M; Rangel, P; Scorza, CA; Scorza, FA, 2005) |
| "We studied the effects of treating status epilepticus (SE) induced by lithium and pilocarpine at postnatal day 15 (P15) or 28 (P28), on the severity of acute SE and of SE-induced epileptogenesis." | 3.73 | Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects. ( Baldwin, RA; Kubova, H; Sankar, R; Suchomelova, L; Thompson, KW; Wasterlain, CG, 2006) |
| " Biochemical studies have proposed a role for AChE in brain mechanisms responsible by development to status epilepticus (SE) induced by pilocarpine." | 3.73 | Acetylcholinesterase activities in hippocampus, frontal cortex and striatum of Wistar rats after pilocarpine-induced status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Viana, GS, 2006) |
| " Recently, we reported eIF2alpha(P) (phosphorylated eIF2alpha) in the brain during SE (status epilepticus) induced by pilocarpine in mice, an animal model of TLE (temporal lobe epilepsy) [Carnevalli, Pereira, Longo, Jaqueta, Avedissian, Mello and Castilho (2004) Neurosci." | 3.73 | Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus. ( Alves, VS; Carnevalli, LS; Castilho, BA; Jaqueta, CB; Mello, LE; Paiva, VN; Pereira, CM; Vattem, KM; Wek, RC, 2006) |
| "The administration of lithium followed by pilocarpine induces status epilepticus (SE) that produces neurodegeneration and the subsequent development of spontaneous recurrent seizures." | 3.73 | Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. ( Dykstra, CM; Gurd, JW; Huo, JZ, 2006) |
| " In this study, we examined possible neuroprotective effects of uridine by administering the agent following lithium-pilocarpine induced status epilepticus." | 3.73 | Effects of uridine in models of epileptogenesis and seizures. ( Holmes, GL; Marolewski, A; Rusche, JR; Zhao, Q, 2006) |
| "The effect of glycemic state on status epilepticus (SE) development was studied in animals of different ages, submitted to pilocarpine model of epilepsy." | 3.73 | Effect of glycemic state in rats submitted to status epilepticus during development. ( Amado, D; Carvalho, FF; Cavalheiro, EA; Cruz, JW; da Graça Naffah-Mazzacoratti, M; Fernandes, MJ; Perosa, SR; Santiago, JF; Siliano, MR, 2006) |
| " Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE)." | 3.73 | Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus. ( Borges, K; Dingledine, R; Irier, H; McDermott, D; Smith, Y, 2006) |
| " In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2h during pilocarpine induced status epilepticus, and never recovered." | 3.73 | Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. ( Burgunder, JM; Chang, ML; Chia, SC; Ma, DL; Probst, A; Tang, FR; Tang, YC, 2006) |
| "We developed a rat pilocarpine seizure/status epilepticus (SE) model, which closely resembles 1." | 3.73 | Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure. ( Gordon, RK; Nambiar, MP; Ratcliffe, RH; Rezk, PE; Steele, KE; Tetz, LM, 2006) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 3.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "Lithium-pilocarpine induces status epilepticus (SE), leading to extensive damage and spontaneous recurrent seizures (SRS)." | 3.73 | The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy. ( Ferrandon, A; François, J; Koning, E; Nehlig, A, 2006) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.73 | Effect of gabaergic, glutamatergic, antipsychotic and antidepressant drugs on pilocarpine-induced seizures and status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Viana, GS, 2006) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.73 | Pharmacological studies of the opioids, mood stabilizer and dopaminergic drugs on pilocarpine-induced seizures and status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Vasconcelos, SM; Viana, GS, 2006) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 3.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| "The rat brain was investigated with structural and functional magnetic resonance imaging (MRI) 12 h after the arrest of pilocarpine-induced status epilepticus lasting 4 h." | 3.72 | Magnetic resonance imaging of changes elicited by status epilepticus in the rat brain: diffusion-weighted and T2-weighted images, regional blood volume maps, and direct correlation with tissue and cell damage. ( Bentivoglio, M; Fabene, PF; Marzola, P; Sbarbati, A, 2003) |
| " Hippocampal neurogenesis may be a critical step in the development of MFS, given that it is enhanced by at least 2-fold in the aftermath of pilocarpine-induced status epilepticus." | 3.72 | Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanism. ( Jacobs, BL; Radley, JJ, 2003) |
| " To determine whether early-life insults that lead to epilepsy result in similar structural changes, we subjected rat pups to lithium-pilocarpine-induced status epilepticus during postnatal development (day 20) and examined them as adults for the occurrence of spontaneous seizures and alterations in hippocampal morphology." | 3.72 | Epilepsy after early-life seizures can be independent of hippocampal injury. ( Brooks-Kayal, AR; Budreck, EC; Raol, YS, 2003) |
| "Distribution of LiCl/pilocarpine status epilepticus-induced neuronal damage was studied in the piriform cortex and in adjoining structures in 12-day-old, 25-day-old and adult rats." | 3.72 | Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent. ( Druga, R; Haugvicová, R; Kubová, H; Suchomelová, L, 2003) |
| "3 g/L) for 15 days before the induction of status epilepticus (SE) by lithium-pilocarpine and for 7 days after SE." | 3.72 | Prolonged low-dose caffeine exposure protects against hippocampal damage but not against the occurrence of epilepsy in the lithium-pilocarpine model in the rat. ( Ferrandon, A; Koning, E; Leroy, C; Nehlig, A; Rigoulot, MA, 2003) |
| "To determine whether a pharmacologic treatment could delay or prevent the epileptogenesis induced by status epilepticus (SE) through the protection of some brain areas, we studied the effects of the long-term exposure to pregabalin (PGB) on neuronal damage and epileptogenesis induced by lithium-pilocarpine SE." | 3.72 | Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat. ( André, V; Ferrandon, A; Koning, E; Nehlig, A; Rigoulot, MA, 2003) |
| "We applied nonlinear analysis to the results of electroencephalography (EEG) in a pilocarpine-induced status epilepticus (SE) model to characterize nonlinear dynamics according to SE phase." | 3.72 | Nonlinear dynamic characteristics of electroencephalography in a high-dose pilocarpine-induced status epilepticus model. ( Jung, KY; Kim, DW; Kim, JM, 2003) |
| " Here, we investigated the effects of antazoline on NMDA toxicity and current in rat hippocampal neuronal cultures, and on an in vivo model of status epilepticus." | 3.72 | Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus. ( Bockaert, J; Lafon-Cazal, M; Lerner-Natoli, M; Milhaud, D; Rondouin, G, 2003) |
| "High doses of the muscarinic cholinergic agonist, pilocarpine, result in behavioural changes, seizures and status epilepticus in rats." | 3.72 | [Acute alterations of neurotransmitters levels in striatum of young rat after pilocarpine-induced status epilepticus]. ( de Freitas, RM; de Sousa, FC; Fonteles, MM; Vasconcelos, SM; Viana, GS, 2003) |
| " To characterize the response of ectopic hilar granule cells to perforant path stimulation, intracellular recordings were made in hippocampal slices from rats that had pilocarpine-induced status epilepticus and subsequent spontaneous recurrent seizures." | 3.72 | Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizures. ( Berger, RE; Goodman, JH; Pierce, JP; Scharfman, HE; Sollas, AE, 2003) |
| " The rats subjected to lithium-pilocarpine (Li/PC)-induced status epilepticus at P21 were grouped as the SE group." | 3.72 | Long-term effects of early-life malnutrition and status epilepticus: assessment by spatial navigation and CREB(Serine-133) phosphorylation. ( Hsieh, CS; Huang, LT; Lai, MC; Liou, CW; Wang, CA; Wang, CL; Yang, CH; Yang, SN, 2003) |
| " To assess this hypothesis, the pilocarpine model of temporal lobe epilepsy was selected because an important reorganization of the glutamatergic network, which includes an aberrant sprouting of granule cell axons, neo-synaptogenesis, and dendritic spine remodeling, is well established in the dentate gyrus." | 3.72 | Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures. ( Ben-Ari, Y; Esclapez, M; Fattoum, A; Ferhat, L; Represa, A; Shirao, T, 2003) |
| "We induced status epilepticus in rats, by using lithium-pilocarpine, and then 2-12 weeks later, used whole-cell voltage-clamp to examine voltage-activated sodium currents of acutely dissociated layer V neurons." | 3.72 | Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy. ( Agrawal, N; Alonso, A; Ragsdale, DS, 2003) |
| "Administration of pilocarpine causes epilepsy in rats if status epilepticus (SE) is induced at an early age." | 3.72 | Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life. ( Cavalheiro, EA; Ferreira, BL; Timo-Iaria, C; Valle, AC, 2003) |
| " Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE)." | 3.72 | Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus. ( Ballester, G; Bonilha, SM; Ewerton, FI; Hamani, C; Lozano, AM; Mello, LE, 2004) |
| "To determine the fate of newborn dentate granule cells (DGCs) after lithium-pilocarpine-induced status epilepticus (SE) in an immature rat." | 3.72 | Fate of newborn dentate granule cells after early life status epilepticus. ( Brooks-Kayal, AR; Maronski, M; Porter, BE, 2004) |
| "In this work, we show extensive phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2alpha) occurring in the brain of mice subjected to 30 min of status epilepticus induced by pilocarpine." | 3.72 | Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice. ( Avedissian, M; Carnevalli, LS; Castilho, BA; Jaqueta, CB; Longo, BM; Mello, LE; Pereira, CM, 2004) |
| "At 4 h during pilocarpine-induced status epilepticus (DPISE) in rat, protein kinase C (PKC)beta1, PKCbeta2, and PKCgamma were induced at the border between the stratum oriens and alveus (O/A border) of CA1 in the hippocampus." | 3.72 | Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus. ( Chen, Y; Chia, SC; Gao, H; Lee, WL; Loh, YT; Tang, FR, 2004) |
| "Adult rats were treated with pilocarpine to induce status epilepticus." | 3.72 | Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats. ( Buckmaster, PS, 2004) |
| " After pilocarpine-induced status epilepticus (SE) in mice most hilar neurons died and neuropeptide Y (NPY) immunoreactivity appeared in the dentate inner molecular layer (IML) after 10-31 days indicative of MFS." | 3.72 | Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice. ( Borges, K; Dingledine, R; McDermott, DL, 2004) |
| " Experimental status epilepticus was induced with pilocarpine, and Ara-C or vehicle alone was infused continuously with an osmotic minipump." | 3.72 | Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Chu, K; Jeong, SW; Jung, KH; Kim, JY; Kim, M; Lee, SK; Lee, ST; Roh, JK; Song, YM, 2004) |
| "The aim of the study was to investigate the lipid peroxidation levels, nitrite formation, GABAergic and glutamatergic receptor densities in the hippocampus, frontal cortex and striatum of Wistar rats after seizures and status epilepticus (SE) induced by pilocarpine." | 3.72 | Pilocarpine-induced status epilepticus in rats: lipid peroxidation level, nitrite formation, GABAergic and glutamatergic receptor alterations in the hippocampus, striatum and frontal cortex. ( Fonteles, MM; Freitas, RM; Sousa, FC; Vasconcelos, SM; Viana, GS, 2004) |
| "The mechanism underlying the vulnerability of the brain to status epilepticus (SE) induced by pilocarpine remains unknown." | 3.72 | Catalase activity in cerebellum, hippocampus, frontal cortex and striatum after status epilepticus induced by pilocarpine in Wistar rats. ( Fonteles, MM; Freitas, RM; Nascimento, VS; Sousa, FC; Vasconcelos, SM; Viana, GS, 2004) |
| "The administration of pilocarpine (PILO) is widely recognized as resulting in an experimental model of temporal lobe epilepsy; it is characterized by induction of status epilepticus (SE) and spontaneous recurrent seizures after a latent period." | 3.72 | Neuroethological study of status epilepticus induced by systemic pilocarpine in Wistar audiogenic rats (WAR strain). ( Furtado, Mde A; Garcia-Cairasco, N; Oliveira, JA; Rossetti, F, 2004) |
| " BDNF mRNA and protein accumulate in dendrites in all hippocampal subfields after pilocarpine seizures and in selected subfields after other epileptogenic stimuli (kainate and kindling)." | 3.72 | Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. ( Armellin, M; Bregola, G; Cattaneo, A; Giulianini, PG; Paradiso, B; Simonato, M; Steward, O; Tongiorgi, E; Zucchini, S, 2004) |
| "The status epilepticus (SE) induced in rats by lithium-pilocarpine (Li-pilo) shares many common features with soman-induced SE including a glutamatergic phase that is inhibited by NMDA antagonists." | 3.72 | Differential neuroprotective effects of the NMDA receptor-associated glycine site partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine in lithium-pilocarpine status epilepticus. ( Griffith, JW; Peterson, SL; Purvis, RS, 2004) |
| "Pilocarpine-induced status epilepticus (SE) is an useful model to study the involvement of neurotransmitter systems as epileptogenesis modulators." | 3.72 | Monoamine levels after pilocarpine-induced status epilepticus in hippocampus and frontal cortex of Wistar rats. ( Fonteles, MM; Freitas, RM; Souza, FC; Vasconcelos, SM; Viana, GS, 2004) |
| "We studied the effects of TPM on mitochondrial function in the pilocarpine rat model of chronic epilepsy and in isolated mitochondria from rat brain." | 3.72 | The mechanism of neuroprotection by topiramate in an animal model of epilepsy. ( Debska-Vielhaber, G; Elger, CE; Kudin, AP; Kunz, WS; Vielhaber, S, 2004) |
| " In this study, immature rats were exposed to status epilepticus (SE) followed by a series of 25 flurothyl-induced seizures, SE alone, 25 flurothyl-induced seizures alone, or no seizures." | 3.72 | Cognitive impairment following status epilepticus and recurrent seizures during early development: support for the "two-hit hypothesis". ( Hoffmann, AF; Holmes, GL; Zhao, Q, 2004) |
| "For half of the animals (nine of 17) subject to pilocarpine-induced status epilepticus (SE), when assessed 60 days later, variable levels of reactive astrocytes were seen in many thalamic, hippocampal, amygdalar, and neocortical areas." | 3.71 | Characterization of reactive astrocytes in the chronic phase of the pilocarpine model of epilepsy. ( Garzillo, CL; Mello, LE, 2002) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 3.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "This study characterized the electrophysiological and neuropathological changes in rat brains caused by pilocarpine (PILO)-induced status epilepticus (SE) of different duration." | 3.71 | Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations. ( Klitgaard, H; Margineanu, DG; Matagne, A; Vanneste-Goemaere, J, 2002) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 3.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| " Using a chromatin immunoprecipitation assay, we found that acetylation of histone H4 in rat hippocampal CA3 neurons was reduced at the glutamate receptor 2 (GluR2; GRIA2) glutamate receptor promoter but increased at brain-derived neurotrophic factor promoter P2 as soon as 3 hr after induction of status epilepticus by pilocarpine." | 3.71 | Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus. ( Dingledine, R; Doherty, JJ; Huang, Y, 2002) |
| " We determined whether caspase-3 is activated by lithium-pilocarpine-induced status epilepticus in six brain regions with necrosis-induced DNA laddering." | 3.71 | Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage. ( Fujikawa, DG; Ke, X; Shinmei, SS; Trinidad, RB; Wu, A, 2002) |
| " As in patients, the consequences of the lithium-pilocarpine-induced status epilepticus (SE) are age dependent, and only a subset of 21-day-old rats will develop epilepsy." | 3.71 | Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model. ( Leroy, C; Namer, IJ; Nehlig, A; Roch, C, 2002) |
| " In adult rats, the only effective dose and agent was 125 ng V2 receptor antagonist, which prevented pilocarpine-induced status epilepticus, extended the status epilepticus latency and improved the 24 h survival rate." | 3.71 | Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy. ( Gulec, G; Noyan, B, 2002) |
| "The aim of the study was to detect by texture analysis non easily visible anomalies of magnetic resonance (MR) images of piriform and entorhinal cortices relevant to the lithium-pilocarpine (Li-Pilo) model of temporal lobe epilepsy in rats." | 3.71 | Detection of late epilepsy by the texture analysis of MR brain images in the lithium-pilocarpine rat model. ( Chambron, J; Mauss, Y; Namer, IJ; Roch, C; Yu, O, 2002) |
| "The expression of metabotropic glutamate receptor 8 (mGluR8) was studied in the rat hippocampus after pilocarpine-induced status epilepticus (APISE) by light immunohistochemistry and immunoelectron microscopy." | 3.71 | Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus. ( Lee, WL; Ling, EA; Sim, MK; Tang, FR; Yang, J, 2001) |
| "Pilocarpine induced time-limited nonconvulsive status epilepticus (NCSE)." | 3.71 | An animal model of nonconvulsive status epilepticus: a contribution to clinical controversies. ( Druga, R; Hlinák, Z; Krsek, P; Kubová, H; Mares, P; Mikulecká, A, 2001) |
| " Therefore, intracellular recording and intracellular dye injection were used to characterize hilar cells in hippocampal slices from pilocarpine-treated rats that had status epilepticus and recurrent seizures ('epileptic' rats)." | 3.71 | Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells. ( Goodman, JH; Scharfman, HE; Smith, KL; Sollas, AL, 2001) |
| " Using the epilepsy model obtained by systemic administration of pilocarpine (PILO) in rats, we investigated the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as well as the hydroperoxide (HPx) concentration in the hippocampus of rats during status epilepticus (SE), silent and chronic periods." | 3.71 | Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats. ( Abdalla, DS; Amado, D; Bellissimo, MI; Cavalheiro, EA; Ferreira, EC; Naffah-Mazzacoratti, MG, 2001) |
| "The expression of metabotropic glutamate receptor 1alpha was studied in the rat hippocampus after pilocarpine-induced status epilepticus by Western blot and immunocytochemistry at both light and electron microscopic levels." | 3.71 | Expression of metabotropic glutamate receptor 1alpha in the hippocampus of rat pilocarpine model of status epilepticus. ( Lee, WL; Ling, EA; Sim, MK; Tang, FR; Yang, J, 2001) |
| "The aim of this study was to determine the effect of the duration of pilocarpine-induced status epilepticus (SE) on subsequent cognitive function in rats." | 3.71 | Effect of duration of pilocarpine-induced status epilepticus on subsequent cognitive function in rats. ( Balakrishnan, S; Nidhi, G; Pandhi, P, 2001) |
| " Multiple intracerebroventricular infusions of caspase inhibitors (pancaspase inhibitor zVADfmk, and caspase 3 and 9 inhibitor) prior to, just after, 1 day after, and 1 week following 2 h of lithium-pilocarpine-induced status epilepticus reduced the number of terminal deoxynucleotidyl transferase-mediated fluorescein-dUTP nick-end labelled (TUNEL) cells and increased the number of bromodeoxyuridine (BrdU) -stained proliferated cells in the subgranular zone at 1 week." | 3.71 | Caspase inhibitors increase short-term survival of progenitor-cell progeny in the adult rat dentate gyrus following status epilepticus. ( Ekdahl, CT; Elmér, E; Lindvall, O; Mohapel, P, 2001) |
| "Rat pups age of 14 postnatal day (P14) were subjected to lithium-pilocarpine (Li-PC) model of status epilepticus (SE)." | 3.71 | Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss. ( Hsu, HY; Huang, LT; Lai, MC; Liou, CW; Tung, YR; Wang, TJ; Wu, CL, 2001) |
| " Lithium-pilocarpine-induced status epilepticus is associated with extended damage in adult rats, mostly in the forebrain limbic areas and thalamus, whereas damage was moderate in 21-day-old rats (P21) or absent in P10 rats." | 3.71 | Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage. ( Ferrandon, A; Nehlig, A; Pereira de Vasconcelos, A, 2002) |
| " This study investigated p53 expression in the immature and adult rat brain following status epilepticus induced by the administration of lithium-pilocarpine (LPSE)." | 3.71 | Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus. ( Liu, H; Sankar, R; Schreiber, SS; Shin, D; Sun, N; Tan, Z; Wasterlain, CG, 2002) |
| " Recent studies have demonstrated an age-dependent induction of both p53 mRNA and protein in the rat brain following lithium-pilocarpine-mediated status epilepticus (LPSE)." | 3.71 | Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus. ( Liu, H; Sankar, R; Schreiber, SS; Shin, D; Tan, Z; Tu, W; Wasterlain, CG, 2002) |
| "Here, we investigated whether aminophylline, an adenosine receptor antagonist used usually as a treatment for premature apnea, had synergistic effects on status epilepticus in the developing brain." | 3.71 | Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats. ( Cheng, SC; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, TJ; Wu, CL; Yang, SN, 2002) |
| " To address this issue further, we asked whether the new hilar granule cells were active during spontaneous limbic seizures that follow status epilepticus induced by pilocarpine injection." | 3.71 | Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus. ( Goodman, JH; Scharfman, HE; Sollas, AL, 2002) |
| " Using digital imaging and fluorescence microscopy it is possible to evaluate neuronal ethidium accumulation in specific brain regions of rats damaged in the lithium-pilocarpine model of status epilepticus." | 3.71 | Hydroethidine detection of superoxide production during the lithium-pilocarpine model of status epilepticus. ( Liu, KJ; Liu, S; Morrow, D; Peterson, SL, 2002) |
| "Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures." | 3.71 | The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures. ( Berkeley, JL; Decker, MJ; Levey, AI, 2002) |
| " The pilocarpine model of limbic epilepsy involves inducing status epilepticus (SE) with the subsequent development of spontaneous recurrent seizures (SRSs) and is widely accepted as a model of limbic epilepsy in humans." | 3.70 | NMDA receptor activation during status epilepticus is required for the development of epilepsy. ( DeLorenzo, RJ; Rice, AC, 1998) |
| "In order to follow the spatial and temporal evolution of neuronal damage, cellular activation and stress responses subsequent to lithium-pilocarpine seizures of various durations in the adult rat, we analyzed the expression of Fos protein and local cerebral glucose utilization as markers of cellular activation, HSP72 immunoreactivity and acid fuchsin staining as indicators of cellular stress and injury, and Cresyl violet staining for the assessment of neuronal damage." | 3.70 | Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. ( Baram, TZ; Fernandes, MJ; Motte, J; Nehlig, A, 1998) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 3.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| "The lithium-pilocarpine model of status epilepticus (SE) was used to study the type and distribution of seizure-induced neuronal injury in the rat and its consequences during development." | 3.70 | Patterns of status epilepticus-induced neuronal injury during development and long-term consequences. ( Liu, H; Mazarati, A; Pereira de Vasconcelos, A; Sankar, R; Shin, DH; Wasterlain, CG, 1998) |
| "The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE)." | 3.70 | Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats. ( Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A, 1999) |
| "Changes in residual ATP concentrations were investigated following subcellular fractionation of rat brain cortex after a prolonged period of status epilepticus induced by sequential administration of lithium and pilocarpine." | 3.70 | Altered residual ATP content in rat brain cortex subcellular fractions following status epilepticus induced by lithium and pilocarpine. ( Nagy, AK; Treiman, DM; Walton, NY, 1998) |
| "Status epilepticus (SE) was induced in adult Long-Evans rats by pilocarpine (320 mg/kg, i." | 3.70 | Cognitive functions after pilocarpine-induced status epilepticus: changes during silent period precede appearance of spontaneous recurrent seizures. ( Broźek, G; Hort, J; Komárek, V; Langmeier, M; Mares, P, 1999) |
| "Functional modulation of gamma-aminobutyric acid(A) (GABA(A)) receptors by Zn(2+), pentobarbital, neuroactive steroid alphaxalone, and flunitrazepam was studied in the cerebral cortex and cerebellum of rats undergoing status epilepticus induced by pilocarpine." | 3.70 | Zinc inhibition of gamma-aminobutyric acid(A) receptor function is decreased in the cerebral cortex during pilocarpine-induced status epilepticus. ( Banerjee, PK; Olsen, RW; Snead, OC, 1999) |
| "In a recent report we have shown that a protein synthesis inhibitor, cycloheximide (CHX), is able to block the mossy fiber sprouting (MFS) that would otherwise be triggered by pilocarpine (Pilo)-induced status epilepticus (SE), and also gives relative protection against hippocampal neuronal death." | 3.70 | Effect of long-term spontaneous recurrent seizures or reinduction of status epilepticus on the development of supragranular mossy fiber sprouting. ( Longo, BM; Mello, LE, 1999) |
| " Pilocarpine-treated rats present status epilepticus, which is followed by a seizure-free period (silent), by a period of spontaneous recurrent seizures (chronic), and the hippocampus of these animals exhibits cell loss and mossy fiber sprouting." | 3.70 | Selective alterations of glycosaminoglycans synthesis and proteoglycan expression in rat cortex and hippocampus in pilocarpine-induced epilepsy. ( Amado, D; Argañaraz, GA; Bellissimo, MI; Cavalheiro, EA; Nader, HB; Naffah-Mazzacoratti, MG; Porcionatto, MA; Scorza, FA; Silva, R, 1999) |
| "The aim of the study was to investigate the changes in biochemical mechanisms facilitating cellular damages in the lithium plus pilocarpine treatment and the resulting status epilepticus." | 3.70 | Lithium plus pilocarpine induced status epilepticus--biochemical changes. ( Eraković, V; Laginja, J; Simonić, A; Varljen, J; Zupan, G, 2000) |
| " As temporal lobe epilepsy is linked to neuronal damage in the hippocampus, we tested the effect of repeated ECS on subsequent status epilepticus (SE) induced by lithium-pilocarpine and leading to cell death and temporal epilepsy in the rat." | 3.70 | Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy. ( André, V; Ferrandon, A; Marescaux, C; Nehlig, A, 2000) |
| "To determine definitively the morphology of neuronal death from lithium-pilocarpine (LPC)-and kainic acid (KA)-induced status epilepticus (SE), and to correlate this with markers of DNA fragmentation that have been associated with cellular apoptosis." | 3.70 | Seizure-induced neuronal necrosis: implications for programmed cell death mechanisms. ( Cai, B; Fujikawa, DG; Shinmei, SS, 2000) |
| "In the rat pilocarpine model, dendrites of DGCs revealed a generalized spine loss immediately after the acute status epilepticus induced by pilocarpine." | 3.70 | Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model. ( Isokawa, M, 2000) |
| " In the present study, we explored the correlation between metabolic changes, neuronal damage, and epileptogenesis during the silent and chronic phases after status epilepticus (SE) induced by lithium-pilocarpine in 10-day-old (P10), 21-day-old (P21), and adult rats." | 3.70 | A metabolic and neuropathological approach to the understanding of plastic changes that occur in the immature and adult rat brain during lithium-pilocarpine-induced epileptogenesis. ( Dubé, C; Marescaux, C; Nehlig, A, 2000) |
| "Rat pups of 2 and 3 weeks postnatal age were subjected to lithium-pilocarpine status epilepticus (LiPC SE)." | 3.70 | Granule cell neurogenesis after status epilepticus in the immature rat brain. ( Katsumori, H; Liu, H; Sankar, R; Shin, D; Wasterlain, CG, 2000) |
| "Estimates of neuronal dropout for approximately 100 structures as defined by Paxinos-Watson were completed for brains of male Wistar albino rats between 1 and 50 days after status epilepticus was evoked by a single systemic injection of lithium and pilocarpine." | 3.70 | Temporal changes in neuronal dropout following inductions of lithium/pilocarpine seizures in the rat. ( Mastrosov, L; Parker, G; Peredery, O; Persinger, MA, 2000) |
| "The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats." | 3.70 | Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus. ( Güleç, G; Noyan, B, 2000) |
| " The present study determined whether status epilepticus-induced HBDs on dentate granule cells occur in the pilocarpine model of temporal lobe epilepsy and whether these dendrites are targeted by mossy fibers." | 3.70 | Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry. ( Nadler, JV; Okazaki, MM; Ribak, CE; Spigelman, I; Tran, PH, 2000) |
| " Transverse slices of the caudal hippocampal formation were prepared from pilocarpine-treated rats that either had or had not developed status epilepticus with subsequent recurrent mossy fiber growth." | 3.70 | Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth. ( Hardison, JL; Nadler, JV; Okazaki, MM, 2000) |
| " We studied the expression of hippocampal substance P in rats in using lithium-pilocarpine model of status epilepticus during development." | 3.70 | Patterns of status epilepticus-induced substance P expression during development. ( Liu, H; Mazarati, AM; Sankar, R; Shin, DH; Wasterlain, CG, 2000) |
| "An animal model of human complex partial status epilepticus induced by lithium chloride and pilocarpine administration was developed in our laboratory." | 3.70 | Nonconvulsive status epilepticus in rats: impaired responsiveness to exteroceptive stimuli. ( Druga, R; Hlinák, Z; Krsek, P; Mares, P; Mikulecká, A, 2000) |
| "Status epilepticus was induced in rats by sequential injections of lithium and pilocarpine." | 3.69 | Cardiac hypertrophy secondary to status epilepticus in the rat. ( Rubinstein, BK; Treiman, DM; Walton, NY, 1995) |
| "Pilocarpine (PILO) induces in rats limbic seizures that become secondarily generalized and evolve to status epilepticus (SE)." | 3.69 | Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats. ( Cavalheiro, EA; Leite, JP, 1995) |
| "We investigated the neuroprotective effect of the noncompetitive N-methyl-D-asparatate (NMDA) antagonist ketamine when administered after onset of lithium-pilocarpine-induced status epilepticus (SE)." | 3.69 | Neuroprotective effect of ketamine administered after status epilepticus onset. ( Fujikawa, DG, 1995) |
| "Status epilepticus induced by pilocarpine in rats induces massive tissue damage comprising neurons and astrocytes (incomplete infarction) in substantia nigra pars reticulata (SNR) and in basal cortical areas (BCTX)." | 3.69 | Loss of immunoreactivity for glial fibrillary acidic protein (GFAP) in astrocytes as a marker for profound tissue damage in substantia nigra and basal cortical areas after status epilepticus induced by pilocarpine in rat. ( Ingvar, M; Schmidt-Kastner, R, 1994) |
| " Using limbic motor status epilepticus induced by pilocarpine to activate neurons in motor and limbic areas, we now demonstrate GDNF mRNA signals in the striatum, hippocampus and cortex using in situ hybridisation." | 3.69 | Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats. ( Bektesh, S; Hoffer, B; Olson, L; Rosenzweig, B; Schmidt-Kastner, R; Tomac, A, 1994) |
| "We studied the efficacy of the competitive NMDA receptor antagonist CGP 40116 in protecting against seizure-induced neuronal necrosis from lithium-pilocarpine-induced status epilepticus (SE)." | 3.69 | The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage. ( Daniels, AH; Fujikawa, DG; Kim, JS, 1994) |
| "The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats." | 3.69 | Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine. ( Jope, RS; Williams, MB, 1994) |
| "Pilocarpine (PILO) administered to rats acutely induces status epilepticus (acute period), which is followed by a transient seizure-free period (silent period), and finally by a chronic phase of spontaneous recurrent seizures (chronic period, SRS) that lasts for the rest of animal's life." | 3.69 | Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. ( Bellíssimo, MI; Cavalheiro, EA; Naffah-Mazzacoratti, MG, 1995) |
| "We studied the effects of status epilepticus (SE) induced by lithium chloride/pilocarpine treatment on gene expression of neurotrophins of the nerve growth factor (NGF) family and of their high-affinity receptors of the tyrosine protein kinase (trk) family in the forebrain." | 3.69 | Change in neurotrophins and their receptor mRNAs in the rat forebrain after status epilepticus induced by pilocarpine. ( Belluardo, N; Bindoni, M; Jiang, XH; Mudò, G; Timmusk, T, 1996) |
| ") or intrahippocampal injection of carbachol (100 micrograms/1 microliters) induced limbic motor seizures in rats, characterized by head weaving and paw treading, rearing and falling, and forepaw myoclonus, developing into status epilepticus." | 3.69 | Regional changes in brain dopamine utilization during status epilepticus in the rat induced by systemic pilocarpine and intrahippocampal carbachol. ( Alam, AM; Starr, MS, 1996) |
| " In this study, a high dose of pilocarpine (300 mg/kg) was used to induce long-lasting, limbic motor status epilepticus and a selective pattern of brain damage." | 3.69 | Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus. ( Humpel, C; Olson, L; Schmidt-Kastner, R; Wetmore, C, 1996) |
| "Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice." | 3.69 | The pilocarpine model of epilepsy in mice. ( Cavalheiro, EA; Priel, MR; Santos, NF, 1996) |
| "Acute seizures and status epilepticus induced by pilocarpine lead to the expression of Fos-like immunoreactivity in several specific brain areas in a manner similar to that of other models of limbic seizures." | 3.69 | Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats. ( Cavalheiro, EA; Finch, DM; Kohman, CM; Mello, LE; Tan, AM, 1996) |
| " To study the age-related susceptibility to the development of chronic epilepsy we used the pilocarpine model of epilepsy (PME)." | 3.69 | Developmental aspects of the pilocarpine model of epilepsy. ( Cavalheiro, EA; dos Santos, NF; Priel, MR, 1996) |
| "Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice." | 3.69 | Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. ( Cohen, AL; Karp, E; Kokate, TG; Rogawski, MA, 1996) |
| " Pilocarpine-induced status epilepticus caused a dramatic and prolonged increase in cell proliferation in the dentate subgranular proliferative zone (SGZ), an area known to contain neuronal precursor cells." | 3.69 | Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. ( Geschwind, DH; Leibowitz, RT; Lowenstein, DH; Parent, JM; Sloviter, RS; Yu, TW, 1997) |
| "Following pilocarpine-induced status epilepticus, rats become chronically epileptic showing 2-3 spontaneous recurrent seizures per week." | 3.69 | Blockade of spreading depression in chronic epileptic rats: reversion by diazepam. ( Cavalheiro, EA; Guedes, RC, 1997) |
| "Since its original description over 10 years ago, the pilocarpine model of status epilepticus (SE) has gained considerable attention." | 3.69 | Status epilepticus induced by pilocarpine and picrotoxin. ( Hamani, C; Mello, LE, 1997) |
| "Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats." | 3.69 | Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. ( George, B; Kulkarni, SK, 1997) |
| "The present work studied the effect of a calcium channel blocker (nimodipine) on rat behavioural changes and brain lesions observed after seizures induced by high doses of pilocarpine (400 mg/kg, s." | 3.69 | Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats. ( Aguiar, LM; de Bruin, VM; de Pinho, RS; de Sousa, FC; Marinho, MM; Viana, GS, 1997) |
| " after they had been assigned to one of 8 groups in a 3-way analysis of variance design that involved (1) induction of limbic seizures by a systemic injection of lithium/pilocarpine, (2) physical restraint, and (3) administration of acepromazine." | 3.68 | Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury. ( Bureau, YR; Persinger, MA, 1993) |
| " Infarcts in substantia nigra pars reticulata were evoked by prolonged pilocarpine-induced status epilepticus." | 3.68 | Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat. ( Bellander, BM; Ingvar, M; Meller, D; Schmidt-Kastner, R, 1993) |
| "The metabolism of GABA and other amino acids was studied in the substantia nigra, the hippocampus and the parietal cortex of rats following microinjections of GAMMA-vinyl-GABA during status epilepticus induced by lithium and pilocarpine." | 3.68 | GABA metabolism in the substantia nigra, cortex, and hippocampus during status epilepticus. ( Baldwin, RA; Baxter, CF; Wasterlain, CG, 1993) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 3.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "Lithium is known to potentiate the ability of pilocarpine to induce status epilepticus in rats." | 3.68 | Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats. ( Baram, TZ; Hirsch, E; Snead, OC, 1992) |
| "The influence of seizures on phosphoinositide hydrolysis and protein kinase C activity was measured in rat hippocampus and cerebral cortex, primarily using a model in which generalized convulsive status epilepticus was induced by administration of LiCl (3 mmole/kg) 20 hr prior to pilocarpine (30 mg/kg)." | 3.68 | Seizures selectively impair agonist-stimulated phosphoinositide hydrolysis without affecting protein kinase C activity in rat brain. ( Jope, RS; Kolasa, K; Ormandy, GC; Song, L, 1992) |
| " The object of this study was to determine the effect of SCC on behavioral and EEG symptomatology in the lithium-pilocarpine model of seizures and status epilepticus in the rat." | 3.68 | Corpus callosotomy in the lithium-pilocarpine model of seizures and status epilepticus. ( Gilles, F; Hirsch, E; Snead, OC; Vergnes, M, 1992) |
| "We describe a novel model of status epilepticus produced by the focal application of bicuculline methiodide into the deep prepiriform cortex of rats pretreated with lithium chloride." | 3.68 | A rodent model of focally evoked self-sustaining status epilepticus. ( Gale, K; Pazos, A; Peterson, CJ; Vinayak, S, 1992) |
| "The specific binding of [3H]hemicholinium-3 ([3H]HCh-3) and high-affinity [3H]choline uptake were measured in rats with status epilepticus induced by lithium and pilocarpine." | 3.68 | [3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine. ( Coyle, JT; Saltarelli, MD; Yamada, K, 1991) |
| "Amino acid concentrations were measured in specific structures from the brains of rats decapitated before and during the course of status epilepticus induced by lithium and pilocarpine, with the stages of status defined by the electroencephalographic (EEG) pattern displayed." | 3.68 | Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine. ( Gunawan, S; Treiman, DM; Walton, NY, 1990) |
| "Male Wistar rats were subjected to pilocarpine-induced status epilepticus and allowed to recover." | 3.68 | Learning impairment in chronic epileptic rats following pilocarpine-induced status epilepticus. ( Cavalheiro, EA; Leite, JP; Lemos, T; Masur, J; Nakamura, EM, 1990) |
| "In the present study glutamate decarboxylase immunoreactivity (GAD-IR) was used to quantify GABAergic neurons in the hippocampus of rats exhibiting spontaneous recurrent seizures following pilocarpine-induced status epilepticus." | 3.68 | GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures. ( Cavalheiro, EA, 1990) |
| "We measured the effects of four weeks of dietary lithium treatment and of status epilepticus induced by administration of pilocarpine to lithium-treated rats on the concentrations of amino acids in four regions of rat brain: cerebral cortex, hippocampus, striatum, and substantia nigra." | 3.67 | Chronic lithium treatment and status epilepticus induced by lithium and pilocarpine cause selective changes of amino acid concentrations in rat brain regions. ( Ferraro, TN; Hare, TA; Jope, RS; Miller, JM, 1989) |
| "Status epilepticus was produced in rats by administering pilocarpine (30 mg/kg, s." | 3.67 | Neurochemical consequences of status epilepticus induced in rats by coadministration of lithium and pilocarpine. ( Jope, RS; Morrisett, RA, 1986) |
| "Status epilepticus (SE) was induced in rats by administration of 3 mmol/kg lithium chloride followed 24 h later by injection of 25 mg/kg pilocarpine." | 3.67 | Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. ( Treiman, DM; Walton, NY, 1988) |
| "The ability of various drugs to prevent the onset of status epilepticus induced by administration of the muscarinic agonist, pilocarpine, to lithium-pretreated rats was determined." | 3.67 | Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. ( Jope, RS; Morrisett, RA; Snead, OC, 1987) |
| "The effects of status epilepticus on the concentration, synthesis, release, and subcellular localization of acetylcholine, the concentration of choline, and the activity of acetylcholinesterase in rat brain regions were studied." | 3.67 | Acetylcholine content in rat brain is elevated by status epilepticus induced by lithium and pilocarpine. ( Jope, RS; Lally, K; Simonato, M, 1987) |
| "Subcutaneous administration of pilocarpine to rats that were pretreated with a small dose of lithium chloride results in the evolution of generalized convulsive status epilepticus." | 3.67 | Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats. ( Jope, RS; Morrisett, RA; Snead, OC, 1986) |
| "2-deoxy-D-glucose has acute antiseizure actions in multiple in vivo and in vitro seizure models, including models of SE induced by the chemo convulsants pilocarpine and kainic acid, suggesting that focal enhanced delivery of 2DG to ictal brain circuits is a potential novel anticonvulsant intervention for the treatment of SE." | 3.01 | 2DG and glycolysis as therapeutic targets for status epilepticus. ( Fountain, NB; Sutula, TP, 2023) |
| "Status epilepticus is a neurological disorder that can result in various neuropathological conditions and presentations." | 3.01 | The applications of the pilocarpine animal model of status epilepticus: 40 years of progress (1983-2023). ( Che Has, AT, 2023) |
| "Based on data from diverse seizure models, we hypothesized that cholinergic mechanisms are involved in the mechanisms underlying ASD resistance of SE." | 2.52 | Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models. ( Löscher, W, 2015) |
| "Thalidomide (TAL) has shown potential therapeutic effects in neurological diseases like epilepsy." | 1.91 | Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model. ( Cumbres-Vargas, IM; Pichardo-Macías, LA; Ramírez-San Juan, E; Zamudio, SR, 2023) |
| "Epilepsy is one of the most common neurologic diseases, and around 30% of all epilepsies, particularly the temporal lobe epilepsy (TLE), are highly refractory to current pharmacological treatments." | 1.91 | A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes. ( Bascuñana, P; Delgado, M; García-García, L; Gomez, F; Hernández-Martín, N; Pozo, MÁ; Rosa, RF; Silván, Á, 2023) |
| "During the 90 min of SE, epileptic seizures were analyzed according to the Racine's Scale." | 1.91 | N-Formyl-Methionyl-Leucyl-Phenylalanine Plays a Neuroprotective and Anticonvulsant Role in Status Epilepticus Model. ( Anselmo-E-Silva, CI; Caixeta, DC; Costa, MA; de Castro, OW; de Melo, IS; de Paula Soares Mendonça, T; de Souza, FMA; Dos Santos, YMO; Freitas-Santos, J; Goulart, LR; Oliveira, KB; Pacheco, ALD; Sabino-Silva, R; Vaz, ER, 2023) |
| "In the PV-ChR2 day 13 group, rates of seizures (p < 0." | 1.72 | Bilateral optogenetic activation of inhibitory cells favors ictogenesis. ( Avoli, M; Etter, G; Lévesque, M; Wang, S; Williams, S, 2022) |
| "Acute brain inflammation after status epilepticus (SE) is involved in blood-brain barrier (BBB) dysfunction and brain edema, which cause the development of post-SE symptomatic epilepsy." | 1.72 | Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice. ( Dohgu, S; Ishihara, Y; Itoh, K; Komori, R; Matsumoto, J; Matsuo, T; Nakatani, M; Ochi, S; Takata, F; Yokota-Nakatsuma, A, 2022) |
| "However, the effect of seizures on Cx expression is controversial." | 1.72 | Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus. ( Andrioli, A; Barresi, V; Bentivoglio, M; Condorelli, DF; Di Liberto, V; Fabene, PF; Frinchi, M; Mudò, G, 2022) |
| "Rosiglitazone has recently been considered as a potential neuroprotective factor in epilepsy because of its antioxidative function." | 1.62 | Rosiglitazone Prevents Autophagy by Regulating Nrf2-Antioxidant Response Element in a Rat Model of Lithium-pilocarpine-induced Status Epilepticus. ( Chen, L; Peng, Y; Qu, Y; Wang, D; Zhu, Y, 2021) |
| "Gastrodin reduced the acute seizure severity in lithium-pilocarpine-induced seizure model." | 1.62 | Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission. ( Chiu, SC; Huang, CW; Lai, MC; Liu, PY; Wu, SN; Yang, CS, 2021) |
| "The pilocarpine animal model has been broadly used to study the acute effects of seizures on neurogenesis and plasticity processes and the resulting epileptogenesis." | 1.62 | Effects of acute seizures on cell proliferation, synaptic plasticity and long-term behavior in adult zebrafish. ( Budaszewski Pinto, C; Cagliari Zenki, K; Calcagnotto, ME; Dalmaz, C; de Sá Couto-Pereira, N; Kawa Odorcyk, F; Losch de Oliveira, D, 2021) |
| "In mice that experienced seizures without status epilepticus (SE), the number of proliferating progenitors and immature neurons were significantly increased, whereas no changes were observed in RGL cells." | 1.56 | The polarity and properties of radial glia-like neural stem cells are altered by seizures with status epilepticus: Study using an improved mouse pilocarpine model of epilepsy. ( Sasaki-Takahashi, N; Seki, T; Shinohara, H; Shioda, S, 2020) |
| "Pilocarpine-treated neonatal rats showed long-term abnormal neurobehavioral parameters." | 1.51 | Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin. ( Chen, SH; Jin, MF; Li, LL; Ni, H, 2019) |
| "Then, spontaneous recurrent seizures (SRS), neuronal loss and astrogliosis were assessed." | 1.51 | The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy. ( Chen, Y; Sun, M; van Luijtelaar, G; Wang, J; Wang, Q, 2019) |
| "Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus." | 1.51 | Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. ( Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J, 2019) |
| "Ifenprodil (20 mg/kg) was administered intraperitoneally (ip) after the stimulation with 3." | 1.48 | Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats? ( Abbasova, K; Kubová, H; Mareš, P, 2018) |
| "Treatment with memantine increase latency to SE onset only in groups treated 3 h before or concomitant with pilocarpine." | 1.48 | Memantine decreases neuronal degeneration in young rats submitted to LiCl-pilocarpine-induced status epilepticus. ( de Oliveira, DL; Dos Santos, TG; Kalinine, E; Mussulini, BHM; Portela, LVC; Zenki, KC; Zimmer, ER, 2018) |
| "Clinical factors contributing to benzodiazepine failure in treating status epilepticus (SE) include suboptimal dosing and seizure duration." | 1.48 | Status epilepticus: Role for etiology in determining response to benzodiazepines. ( Chester, SJ; Goodkin, HP; Hawk, KM; Joshi, S; Rajasekaran, K, 2018) |
| "Mesial temporal lobe epilepsy is a serious brain disorder in adults that is often preceded by an initial brain insult, such as status epilepticus (SE), that after a latent period leads to recurrent seizures." | 1.48 | Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis. ( Cavalheiro, EA; Gomes da Silva, S; Marques, MJG; Naffah-Mazzacoratti, MDG; Scorza, CA; Scorza, FA, 2018) |
| "Meanwhile, cerebral edema, as well as neuronal loss, was decreased in several brain areas in the GBC group." | 1.46 | Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus. ( Gu, Y; Hu, Y; Huang, H; Huang, K; Ji, Z; Lin, Z; Pan, S; Wang, S; Wu, Y; Yang, T, 2017) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 1.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| "Status epilepticus is a common manifestation of nerve agent toxicity and represents a serious medical emergency with high rates of mortality and neurologic injury in those that survive." | 1.46 | Oxidative Stress Contributes to Status Epilepticus Associated Mortality. ( Day, BJ; Liang, LP; Patel, M; Pearson-Smith, JN; Rowley, SD, 2017) |
| " Therefore, in the present study, the neuroprotective effects and mechanisms of vit-D alone or in combination with lamotrigine have been evaluated in the lithium-pilocarpine model of SE in rats." | 1.46 | Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats. ( Abdel-Wahab, AF; Afify, MA; Al Ghamdi, SS; Bamagous, GA; ElSawy, NA; Ibrahim, IAA; Mahfoz, AM; Shahzad, N, 2017) |
| "Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available." | 1.46 | Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis. ( Liang, LP; Patel, M; Pearson, JN; Roberts, LJ; Warren, E, 2017) |
| "In addition, status epilepticus is known to enhance the transient proliferation of adult NPCs, but the c-jun expression pattern was not significantly affected." | 1.46 | c-jun is differentially expressed in embryonic and adult neural precursor cells. ( Kawashima, F; Kurata, H; Maegaki, Y; Mori, T; Saito, K, 2017) |
| "In this study, we observed the seizure behavior induced by kainic acid (20 mg/kg or 30 mg/kg) or pilocarpine (350 mg/kg) in AC8 KO and wild-type mice." | 1.43 | A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice. ( Chen, X; Dong, G; Wang, H; Yun, W; Zheng, C; Zhou, X, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Since traumatic brain injury is one of the strongest determinants of epileptogenesis, the present study focuses on the question whether a moderate long-term physical training can decrease susceptibility to seizures evoked following brain damage." | 1.43 | Physical training decreases susceptibility to pilocarpine-induced seizures in the injured rat brain. ( Gzieło-Jurek, K; Janeczko, K; Kaczyńska, M; Kosonowska, E; Setkowicz, Z, 2016) |
| "The limbic seizures were classified using the Racine's scale, and the amount of wet dog shakes (WDS) was quantified before and during SE." | 1.43 | Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus. ( Cardoso-Sousa, L; Castro, OW; Costa, MA; Duzzioni, M; Garcia-Cairasco, N; Gitaí, DLG; Goulart, LR; Melo, IS; Pacheco, ALD; Pereira, UP; Sabino-Silva, R; Santos, YMO; Silva, NKGT; Tilelli, CQ, 2016) |
| "Thymoquinone (TQ) is a bioactive monomer extracted from black seed (Nigella sativa) oil, which has anti-inflammatory properties in the context of various diseases." | 1.43 | Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus. ( Chen, L; Chen, Y; Feng, Y; Li, B; Luo, Q; Shao, Y; Xie, Y, 2016) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 1.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| " To allow efficient xenotransplantation for the purpose of optimizing potential cell-based therapy of human TLE, we have determined the optimal dosing strategy to produce spontaneous recurring seizures in immunodeficient NodScid mice." | 1.42 | Optimization of pilocarpine-mediated seizure induction in immunodeficient NodScid mice. ( Ahn, S; Chung, S; Cunningham, M; Iskandar, D; Kim, KS; Kim, Y; Leung, A; Luna, MJ; Savvidis, G, 2015) |
| "Mounting evidence suggests that brain inflammation mediated by glial cells may contribute to epileptogenesis." | 1.42 | Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus. ( Gao, B; Gu, J; Mi, X; Wang, N; Wang, W; Wang, X; Zhang, Y, 2015) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 1.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| "Status epilepticus is an emergency condition in patients with prolonged seizure or recurrent seizures without full recovery between them." | 1.42 | State and parameter estimation of a neural mass model from electrophysiological signals during the status epilepticus. ( Castillo-Toledo, B; López-Cuevas, A; Medina-Ceja, L; Ventura-Mejía, C, 2015) |
| "In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα)." | 1.42 | Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats. ( Amorim, BO; Brito, JG; Covolan, L; de Morais, DG; deAlmeida, AC; Ferreira, E; Hamani, C; Nobrega, JN; Nunes, DP; Rodrigues, AM, 2015) |
| "In pilocarpine-treated chronically epileptic rats, we describe a novel mechanism that causes an increased proximal dendritic persistent Na(+) current (INaP)." | 1.42 | Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. ( Beck, H; Becker, A; Kaupp, UB; Kelly, T; Opitz, T; Otte, DM; Pitsch, J; Rennhack, A; Royeck, M; Schoch, S; Woitecki, A; Yaari, Y; Zimmer, A, 2015) |
| "Status epilepticus affected male and female rats differentially." | 1.40 | Effect of lithium-pilocarpine-induced status epilepticus on ultrasonic vocalizations in the infant rat pup. ( Beltrán-Parrazal, L; López-Meraz, ML; Manzo, J; Medel-Matus, JS; Morgado-Valle, C; Pérez-Estudillo, C, 2014) |
| "Brain edema was assessed by means of magnetic resonance imaging (T2 relaxometry) and hippocampal volumetry was used as a marker of neuronal injury." | 1.40 | Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus. ( Chun, KP; Duffy, BA; Lythgoe, MF; Ma, D; Scott, RC, 2014) |
| "Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood." | 1.40 | Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. ( Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z, 2014) |
| "Proglumide (Pgm) is a known cholecystokinin (CCK) antagonist and any changes in the level of CCK and in the number of CCK receptors has been linked with SE." | 1.40 | Ameliorating effects of proglumide on neurobehavioral and biochemical deficits in animal model of status epilepticus. ( Ahmad, M; Wadaan, MA, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 1.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| "Better treatment of status epilepticus (SE), which typically becomes refractory after about 30 min, will require new pharmacotherapies." | 1.39 | A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus. ( Bialer, M; Dudek, FE; Hen, N; Kaufmann, D; Nelson, C; Pouliot, W; Ricks, K; Roach, B; Shekh-Ahmad, T; Yagen, B, 2013) |
| "Pretreatment with baicalin significantly delayed the onset of the first limbic seizures and SE, reduced the mortality rate, and attenuated the changes in the levels of lipid peroxidation, nitrite content and reduced glutathione in the hippocampus of pilocarpine-treated rats." | 1.38 | The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats. ( Gao, F; Jia, RH; Jiang, W; Jing, YY; Li, XW; Liu, YF; Meng, XD; Wang, Y; Zhao, R, 2012) |
| "Ketamine post-SE onset treatment prevented neuronal death in all regions assessed." | 1.38 | Ketamine reduces neuronal degeneration and anxiety levels when administered during early life-induced status epilepticus in rats. ( Córdova, SD; de Oliveira, DL; Loss, CM, 2012) |
| "The effects of cathodal tDCS on convulsions and spatial memory after status epilepticus (SE) in immature animals were investigated." | 1.37 | Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats. ( Abe, T; Eshima, N; Fujiki, M; Kamida, T; Kobayashi, H; Kong, S, 2011) |
| "Status epilepticus was induced in postnatal day 20 Sprague-Dawley rat pups with the chemoconvulsant lithium-pilocarpine and brain tissue was examined with Fluoro-Jade B." | 1.37 | Lithium pilocarpine-induced status epilepticus in postnatal day 20 rats results in greater neuronal injury in ventral versus dorsal hippocampus. ( Dudek, FE; Ekstrand, JJ; Pouliot, W; Scheerlinck, P, 2011) |
| " Our findings strongly suggest that CoQ10 can be considered a safe and effective adjuvant to phenytoin therapy in epilepsy both to ameliorate seizure severity and to protect against seizure-induced oxidative damage by reducing the cognitive impairment and oxidative stress associated with chronic use of phenytoin." | 1.37 | Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress. ( Tawfik, MK, 2011) |
| "Spontaneous recurrent seizures (SRS) were monitored using Racine's seizure severity scale." | 1.36 | Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy. ( Costa-Ferro, ZS; Cunha, FB; DaCosta, JC; Machado, DC; Pedroso, MF; Ribeiro-dos-Santos, R; Soares, MB; Vitola, AS; Xavier, LL, 2010) |
| " Based on pharmacokinetic studies with bumetanide, which showed extremely rapid elimination and low brain penetration of this drug in rats, bumetanide was administered systemically with different dosing protocols, including continuous intravenous infusion." | 1.36 | Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy. ( Brandt, C; Heuchert, N; Löscher, W; Nozadze, M; Rattka, M, 2010) |
| "Status epilepticus is a clinical emergency that can lead to the development of acquired epilepsy following neuronal injury." | 1.36 | Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. ( Carter, DS; DeLorenzo, RJ; Deshpande, LS; Nagarkatti, N, 2010) |
| "Pilocarpine was used to induce SE in OPN(-/-) and OPN(+/+) mice to compare seizure susceptibility, neuropathological markers including real time PCR for inflammatory genes, and osteopontin immunohistochemistry." | 1.35 | Characterization of osteopontin expression and function after status epilepticus. ( Borges, K; Denhardt, DT; Dingledine, R; Gearing, M; Kotloski, R; Rittling, S; Sorensen, ES, 2008) |
| "Edaravone (MCI-186) is a newly developed antioxidative radical scavenger for the treatment of acute cerebral infarction, exerting neuroprotective effects against ischemic insult." | 1.35 | Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus. ( Abe, T; Anan, M; Fujiki, M; Kamida, T; Kobayashi, H; Ooba, H, 2009) |
| "Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon." | 1.35 | Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage. ( Cheng, JT; Huang, CC; Huang, CW; Tsai, JJ; Wu, SN, 2009) |
| " For this study, we used the same pilocarpine ramping-up dosing protocol and behavioral test battery than in a previous study in NMRI mice, thus allowing direct comparison between these two mouse strains." | 1.35 | Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. ( Bankstahl, M; Gröticke, I; Löscher, W; Müller, CJ, 2009) |
| "Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality." | 1.35 | Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus. ( Bracey, JM; Churn, SB; Kurz, JE; Low, B, 2009) |
| "Severity of kindled seizures was assessed in terms of a composite kindled seizure severity score (KSSS)." | 1.35 | Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice. ( Kalra, R; Rehni, AK; Singh, N; Singh, TG, 2009) |
| "Although ventricular arrhythmias have been implicated in SE-related mortality, the effects of this prolonged seizure activity on the cardiac function and susceptibility to arrhythmias have not been directly investigated." | 1.35 | Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats. ( Bealer, SL; Little, JG; Metcalf, CS; Poelzing, S, 2009) |
| "The behavioral signs of the developing epileptic seizures were scored in all rats." | 1.35 | Status epilepticus affects the gigantocellular network of the pontine reticular formation. ( Baracskay, P; Czurkó, A; Juhász, G; Kékesi, KA; Kiglics, V, 2009) |
| "Transition into limbic seizures and recurrent seizures were delayed in both age groups and threshold intensities for limbic ADs were at some intervals higher in SE than in control animals." | 1.35 | Changes of cortical epileptic afterdischarges after status epilepticus in immature rats. ( Kubová, H; Mares, P; Tsenov, G, 2008) |
| "The data indicate that seizure-induced glutamate release is involved in the regulation of Pgp expression, which can be blocked by MK-801." | 1.35 | Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. ( Bankstahl, JP; Bethmann, K; Hoffmann, K; Löscher, W, 2008) |
| "Convulsive status epilepticus is associated with subsequent hippocampal damage and development of mesial temporal sclerosis in a subset of individuals." | 1.34 | Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. ( Bamidele, A; Begum, S; Choy, M; de Castro, SC; Gadian, DG; Greene, ND; Leung, KY; Lythgoe, MF; Scott, RC; Wait, R, 2007) |
| "The pilocarpine model of SE was characterized both behaviorally and electrographically." | 1.33 | Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat. ( Churn, SB; Holbert, WH; Kurz, JE; Lee, AT; Ryan, ML; Singleton, MW, 2005) |
| "The pilocarpine model of SE was characterized both behaviorally and electrographically." | 1.33 | Modulation of CaM kinase II activity is coincident with induction of status epilepticus in the rat pilocarpine model. ( Bracey, JM; Churn, SB; Holbert, WH; Lee, AT; Singleton, MW, 2005) |
| "pilocarpine also did not produce significant difference with respect to the 0." | 1.33 | Arginine vasopressin does not contribute to seizures induced by intracerebroventricularly-injected pilocarpine. ( Gulec, G; Isbil-Buyukcoskun, N, 2005) |
| "Pilocarpine-treated animals represent an established model of mesial temporal lobe epilepsy." | 1.33 | Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus. ( Avoli, M; Baldelli, E; Biagini, G; D'Antuono, M; D'Arcangelo, G; Tancredi, V, 2005) |
| "Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior." | 1.33 | Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. ( Holmes, GL; Liu, Z; Mikati, M; Neill, JC, 2005) |
| "Thereafter, seizures were induced by pilocarpine injections in trained and non-trained control groups." | 1.33 | Physical training decreases susceptibility to subsequent pilocarpine-induced seizures in the rat. ( Mazur, A; Setkowicz, Z, 2006) |
| "Cycloheximide-pilocarpine-treated animals, in contrast, had CGRP and neo-Timm staining similar to controls." | 1.32 | Sprouting of mossy fibers and the vacating of postsynaptic targets in the inner molecular layer of the dentate gyrus. ( Chadi, G; Covolan, L; Longo, B; Mello, LE, 2003) |
| "In all age groups, the dosage of DZP that stopped the seizures at 5 min was not effective in terminating seizures at 60 min." | 1.32 | Diazepam terminates brief but not prolonged seizures in young, naïve rats. ( Goodkin, HP; Holmes, GL; Liu, X, 2003) |
| "Pilocarpine treatment induced downregulation of (M(1)+M(2)) muscarinic receptors and reduced the dissociation constants of (M(1)+M(2)) muscarinic and D(2) dopaminergic receptors, suggesting that these systems exert opposite effects on the regulation of convulsive activity." | 1.32 | Pilocarpine-induced seizures in adult rats: monoamine content and muscarinic and dopaminergic receptor changes in the striatum. ( Bezerra Felipe, CF; Fonteles, MM; Freitas, RM; Nascimento, VS; Oliveira, AA; Viana, GS, 2003) |
| "Prolonged seizures in early childhood are associated with an increased risk of development of epilepsy in later life." | 1.32 | Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility. ( Brooks-Kayal, AR; Hsu, FC; Raol, YS; Zhang, G, 2004) |
| "To test whether seizure-prone phenotypes exhibit increased seizure-related morphological changes, we compared two standard rat strains (Long-Evans hooded and Wistar) and two specially bred strains following status epilepticus." | 1.32 | Strain differences affect the induction of status epilepticus and seizure-induced morphological changes. ( Fahnestock, M; McIntyre, DC; Racine, RJ; Xu, B, 2004) |
| "It is known that evoked seizures can increase neurogenesis in the dentate gyrus in adult rats." | 1.32 | Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis. ( Akman, C; Cha, BH; Holmes, GL; Liu, X; Silveira, DC, 2004) |
| "Spontaneous recurrent seizures were monitored with Racine's seizure severity scale." | 1.32 | Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. ( Chu, K; Jeon, D; Jeong, SW; Jung, KH; Kim, J; Kim, M; Kim, SU; Lee, SK; Lee, ST; Roh, JK; Shin, HS, 2004) |
| "Status epilepticus is a major medical emergency that results in significant alteration of neuronal function." | 1.31 | Status epilepticus results in an N-methyl-D-aspartate receptor-dependent inhibition of Ca2+/calmodulin-dependent kinase II activity in the rat. ( Churn, SB; DeLorenzo, RJ; Kochan, LD; Omojokun, O; Rice, A, 2000) |
| "Pilocarpine was administered systemically (380mg/kg i." | 1.31 | Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus. ( Capek, R; De Koninck, Y; Poirier, JL, 2000) |
| "Status epilepticus is associated with sustained and elevated levels of cytosolic Ca(2+)." | 1.31 | Pilocarpine-induced status epilepticus causes N-methyl-D-aspartate receptor-dependent inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake. ( Churn, SB; DeLorenzo, RJ; Kochan, LD; Parsons, JT, 2000) |
| "Choline is an essential nutrient for rats and humans, and its availability during fetal development has long-lasting cognitive effects (Blusztajn, 1998)." | 1.31 | Protective effects of prenatal choline supplementation on seizure-induced memory impairment. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y, 2000) |
| "Status epilepticus was induced by pilocarpine injection and allowed to continue for 60 min." | 1.31 | A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus. ( Churn, SB; Delorenzo, RJ; Kurz, JE; Parsons, JT; Rana, A; Sheets, D, 2001) |
| "Spontaneous behavioral seizures were observed in BDNF-infused rats (8/32; 25%) but not in controls (0/20; 0%)." | 1.31 | Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor. ( Croll, SD; Goodman, JH; Scharfman, HE; Sollas, AL, 2002) |
| "We examined spontaneous seizure development and correlative axon sprouting in the dentate gyrus of CD-1 and C57BL/6 mice after systemic injection of pilocarpine." | 1.31 | Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice. ( Shibley, H; Smith, BN, 2002) |
| "Behavioral seizures were characterized by sustained or recurrent bouts of clonus in all limbs." | 1.30 | Lithium-pilocarpine status epilepticus in the immature rabbit. ( Thompson, K; Wasterlain, C, 1997) |
| "Pilocarpine-treated animals scored significantly higher on two of the behavioral tests: the Touch test and the Pick-Up test." | 1.30 | Status epilepticus causes long-term NMDA receptor-dependent behavioral changes and cognitive deficits. ( DeLorenzo, RJ; Floyd, CL; Hamm, RJ; Lyeth, BG; Rice, AC, 1998) |
| "The course of untreated epilepsy is not well established." | 1.30 | The course of untreated seizures in the pilocarpine model of epilepsy. ( Arida, RM; Cavalheiro, EA; Peres, CA; Scorza, FA, 1999) |
| "Pilocarpine-treated rats were studied because they not only have seizures and increased BDNF expression in granule cells, but they also have reorganization of granule cell "mossy fiber" axons." | 1.30 | Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus. ( Goodman, JH; Scharfman, HE; Sollas, AL, 1999) |
| "Dizocilpine maleate-pretreated animals responded rapidly to diazepam treatment, even after 60 min of status epilepticus." | 1.30 | N-methyl-D-aspartate receptor activation regulates refractoriness of status epilepticus to diazepam. ( DeLorenzo, RJ; Rice, AC, 1999) |
| "Cell death, reactive gliosis, and axonal sprouting are among the best studied alterations in the epileptic brain." | 1.30 | Differential regulation of cytokine expression following pilocarpine-induced seizure. ( Jankowsky, JL; Patterson, PH, 1999) |
| "Thus, we used two different models of generalized status epilepticus, as widespread elevated neuronal activity, to study in vivo responses of the AMPA receptor mRNA expression in rat forebrain." | 1.29 | Changes in gene expression of AMPA-selective glutamate receptor subunits induced by status epilepticus in rat brain. ( Belluardo, N; Condorelli, DF; Dell'Albani, P; Giuffrida-Stella, AM; Jiang, X; Mudò, G, 1994) |
| "These seizures were followed by seemingly complete neurological recovery." | 1.29 | Long-term behavioral deficits following pilocarpine seizures in immature rats. ( Gatt, A; Holmes, GL; Liu, Z; Mikati, MA; Werner, SJ, 1994) |
| "Initially seizures are discrete, then undergo waxing-and-waning of convulsive/electroencephalographic severity." | 1.29 | Functional mapping of the early stages of status epilepticus: a 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat. ( Handforth, A; Treiman, DM, 1995) |
| " These results demonstrated that both acute and chronic administration of lithium enhance cholinergic function in vivo." | 1.27 | Status epilepticus is produced by administration of cholinergic agonists to lithium-treated rats: comparison with kainic acid. ( Jope, RS; Morrisett, RA; Snead, OC, 1987) |
| "Behaviorally, the animals showed motor seizures which varied between stages I through IV, with evidence of extensive bilateral hemispheric involvement through much of the seizure episode." | 1.27 | Status epilepticus facilitated by pilocarpine in amygdala-kindled rats. ( Buterbaugh, GG; Keyser, DO; Michelson, HB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (0.90) | 18.7374 |
| 1990's | 83 (8.28) | 18.2507 |
| 2000's | 345 (34.40) | 29.6817 |
| 2010's | 446 (44.47) | 24.3611 |
| 2020's | 120 (11.96) | 2.80 |
| Authors | Studies |
|---|---|
| Yi, YJ | 1 |
| Ran, X | 2 |
| Xiang, J | 2 |
| Li, XY | 1 |
| Jiang, L | 7 |
| Chen, HS | 1 |
| Hu, Y | 5 |
| Righes Marafiga, J | 1 |
| Vendramin Pasquetti, M | 1 |
| Calcagnotto, ME | 3 |
| Ma, KG | 1 |
| Hu, HB | 2 |
| Zhou, JS | 3 |
| Ji, C | 1 |
| Yan, QS | 1 |
| Peng, SM | 1 |
| Ren, LD | 1 |
| Yang, BN | 1 |
| Xiao, XL | 6 |
| Ma, YB | 2 |
| Wu, F | 2 |
| Si, KW | 4 |
| Wu, XL | 5 |
| Liu, JX | 15 |
| Vigier, A | 1 |
| Partouche, N | 1 |
| Michel, FJ | 1 |
| Crépel, V | 1 |
| Marissal, T | 1 |
| Singh, S | 2 |
| Singh, TG | 3 |
| Singh, M | 1 |
| Najda, A | 1 |
| Nurzyńska-Wierdak, R | 1 |
| Almeer, R | 1 |
| Kamel, M | 1 |
| Abdel-Daim, MM | 1 |
| Mátyás, A | 1 |
| Borbély, E | 1 |
| Mihály, A | 1 |
| Pascoal, VDB | 2 |
| Marchesini, RB | 1 |
| Athié, MCP | 1 |
| Matos, AHB | 1 |
| Conte, FF | 1 |
| Pereira, TC | 1 |
| Secolin, R | 1 |
| Gilioli, R | 1 |
| Malheiros, JM | 2 |
| Polli, RS | 1 |
| Tannús, A | 2 |
| Covolan, L | 12 |
| Pascoal, LB | 1 |
| Vieira, AS | 1 |
| Cavalheiro, EA | 52 |
| Cendes, F | 1 |
| Lopes-Cendes, I | 2 |
| Dal Pai, J | 1 |
| da Silva, JC | 1 |
| Sanabria, V | 2 |
| Amorim, RP | 2 |
| Predebon, G | 1 |
| Cossa, AC | 1 |
| Trindade-Filho, E | 1 |
| Amado, D | 16 |
| Butler, CR | 1 |
| Westbrook, GL | 1 |
| Schnell, E | 1 |
| Park, S | 4 |
| Zhu, J | 3 |
| Jeong, KH | 6 |
| Kim, WJ | 5 |
| Fábera, P | 1 |
| Uttl, L | 1 |
| Kubová, H | 21 |
| Tsenov, G | 5 |
| Mareš, P | 19 |
| Mallmann, MP | 1 |
| Mello, FK | 2 |
| Neuberger, B | 2 |
| da Costa Sobral, KG | 1 |
| Fighera, MR | 6 |
| Royes, LFF | 2 |
| Furian, AF | 7 |
| Oliveira, MS | 9 |
| Moradi, F | 1 |
| Eslami, F | 2 |
| Rahimi, N | 3 |
| Koohfar, A | 1 |
| Shayan, M | 2 |
| Maadani, M | 1 |
| Ghasemi, M | 2 |
| Dehpour, AR | 4 |
| Seo, GY | 1 |
| Neal, ES | 2 |
| Han, F | 1 |
| Vidovic, D | 1 |
| Nooru-Mohamed, F | 1 |
| Dienel, GA | 1 |
| Sullivan, MA | 1 |
| Borges, K | 7 |
| Shehata, NI | 1 |
| Abdelsamad, MA | 1 |
| Amin, HAA | 1 |
| Sadik, NAH | 1 |
| Shaheen, AA | 1 |
| Trindade-Filho, EM | 3 |
| Pai, JD | 1 |
| Castro, DN | 1 |
| Silva, ATMD | 1 |
| Costa, AF | 1 |
| Vieira, JSS | 1 |
| Santos, SDBD | 1 |
| Félix, VB | 1 |
| Leão, SABF | 1 |
| Zambrano, LI | 1 |
| Saldanha-Filho, AJM | 1 |
| Carvalho, EGA | 1 |
| Cavalcante, JBN | 1 |
| Quintella, GB | 1 |
| Lino, ATS | 1 |
| Costa, MV | 1 |
| Lima, JA | 1 |
| Tavares, MMA | 1 |
| de Melo, MR | 1 |
| Mousinho, KC | 1 |
| Biase, CLCL | 1 |
| Leite, ML | 1 |
| Costa, PJMS | 1 |
| Becker, EL | 1 |
| Moura, IMFB | 1 |
| Silva, JCD | 1 |
| Chen, L | 11 |
| Zhu, L | 3 |
| Xu, J | 7 |
| Xu, P | 2 |
| Han, Y | 4 |
| Chang, L | 2 |
| Wu, Q | 4 |
| Godale, CM | 2 |
| Parkins, EV | 1 |
| Gross, C | 1 |
| Danzer, SC | 8 |
| Zhang, J | 3 |
| Qiao, N | 1 |
| Wang, J | 6 |
| Li, B | 3 |
| Lévesque, M | 9 |
| Wang, S | 11 |
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| Hirsch, E | 2 |
| Falter, H | 1 |
| Chrétien, R | 1 |
| Kolasa, K | 1 |
| Song, L | 1 |
| Ormandy, GC | 2 |
| Turski, L | 1 |
| Mazzacoratti, MG | 1 |
| Vergnes, M | 1 |
| Gilles, F | 1 |
| Peterson, CJ | 1 |
| Vinayak, S | 1 |
| Pazos, A | 1 |
| Gale, K | 1 |
| Yamada, K | 1 |
| Saltarelli, MD | 1 |
| Coyle, JT | 1 |
| Heim, C | 1 |
| Sontag, KH | 1 |
| Gunawan, S | 1 |
| Nakamura, EM | 1 |
| Masur, J | 1 |
| Miller, JM | 1 |
| Ferraro, TN | 1 |
| Hare, TA | 1 |
| Morrisett, RA | 4 |
| Lally, K | 1 |
| Buterbaugh, GG | 1 |
| Michelson, HB | 1 |
| Keyser, DO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury[NCT04945213] | Phase 3 | 312 participants (Anticipated) | Interventional | 2023-01-10 | Recruiting | ||
| Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals[NCT00600717] | 420 participants (Anticipated) | Observational | 2000-11-01 | Enrolling by invitation | |||
| Efficacy of Combined Ketamine and Midazolam for Treatment of Generalized Convulsive Status Epilepticus in Children .[NCT05779657] | Phase 2/Phase 3 | 144 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| Phase 1 Study of Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy[NCT00916266] | Phase 1 | 20 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885] | Phase 2 | 6 participants (Anticipated) | Interventional | 2022-08-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 reviews available for pilocarpine and Absence Status
| Article | Year |
|---|---|
2DG and glycolysis as therapeutic targets for status epilepticus.
Topics: Deoxyglucose; Glucose; Glycolysis; Humans; Pilocarpine; Seizures; Status Epilepticus | 2023 |
The applications of the pilocarpine animal model of status epilepticus: 40 years of progress (1983-2023).
Topics: Animals; Disease Models, Animal; Electroencephalography; Models, Animal; Pilocarpine; Status Epilept | 2023 |
Rational polytherapy in the treatment of cholinergic seizures.
Topics: Animals; Anticonvulsants; Cholinesterase Inhibitors; Drug Therapy, Combination; Ketamine; Male; Mida | 2020 |
Early polytherapy for benzodiazepine-refractory status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Administration Schedule; Drug Resistant Epilepsy; Dr | 2019 |
The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mice; Pilocarpine; Rats; Rode | 2021 |
Systematic review and meta-analysis of the efficacy of different exercise programs in pilocarpine induced status epilepticus models.
Topics: Animals; Disease Models, Animal; Exercise Therapy; Physical Conditioning, Animal; Pilocarpine; Seizu | 2017 |
Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions.
Topics: Animals; Convulsants; Electric Stimulation Therapy; Flurothyl; Humans; Kainic Acid; Neurodegenerativ | 2013 |
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug T | 2015 |
The pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal L | 2008 |
The pilocarpine model of epilepsy: what have we learned?
Topics: Animals; Death, Sudden; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Exe | 2009 |
Comparison of status epilepticus models induced by pilocarpine and nerve agents - a systematic review of the underlying aetiology and adopted therapeutic approaches.
Topics: Animals; Brain; Chemical Warfare Agents; Humans; Pilocarpine; Sarin; Soman; Status Epilepticus | 2011 |
New insights from the use of pilocarpine and kainate models.
Topics: Animals; Convulsants; Electroencephalography; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Mus | 2002 |
Basic mechanisms in status epilepticus: role of calcium in neuronal injury and the induction of epileptogenesis.
Topics: Animals; Calcium; Cell Death; Drug Interactions; gamma-Aminobutyric Acid; Humans; Kainic Acid; Neuro | 2006 |
Neuropeptide Y in the recurrent mossy fiber pathway.
Topics: Animals; Epilepsy; Humans; Mice; Mossy Fibers, Hippocampal; Neuronal Plasticity; Neuropeptide Y; Pil | 2007 |
Lithium-pilocarpine neurotoxicity: a potential model of status epilepticus.
Topics: Animals; Disease Models, Animal; Lithium; Pilocarpine; Status Epilepticus | 1995 |
Recurrent seizures in the developing brain are harmful.
Topics: Adult; Animals; Brain; Brain Injuries; Child; Disease Models, Animal; Entorhinal Cortex; Epilepsy; H | 1997 |
1 trial available for pilocarpine and Absence Status
| Article | Year |
|---|---|
Two decades of research towards a potential first anti-epileptic drug.
Topics: Animals; Disease Models, Animal; Humans; Pharmaceutical Preparations; Pilocarpine; Seizures; Status | 2021 |
986 other studies available for pilocarpine and Absence Status
| Article | Year |
|---|---|
Effect of gap junction blockers on hippocampal ripple energy expression in rats with status epilepticus.
Topics: Animals; Gap Junctions; Hippocampus; Pilocarpine; Rats; Seizures; Status Epilepticus | 2021 |
In vitro Oscillation Patterns Throughout the Hippocampal Formation in a Rodent Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Pilocarpine; Rats; | 2021 |
Neuronal Glypican4 promotes mossy fiber sprouting through the mTOR pathway after pilocarpine-induced status epilepticus in mice.
Topics: Animals; Cells, Cultured; Glypicans; Male; Mice; Mossy Fibers, Hippocampal; Muscarinic Agonists; Pil | 2022 |
Substantial outcome improvement using a refined pilocarpine mouse model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Male; Mice; Pilocarpine; Seizures; | 2021 |
Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice.
Topics: Animals; Anticonvulsants; Chondroitin Sulfates; Male; Mice; Molecular Docking Simulation; Neuroprote | 2021 |
Hippocampal Sclerosis in Pilocarpine Epilepsy: Survival of Peptide-Containing Neurons and Learning and Memory Disturbances in the Adult NMRI Strain Mouse.
Topics: Aging; Animals; Calbindin 2; Cell Proliferation; Cell Survival; Densitometry; Epilepsy; Hippocampus; | 2021 |
Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Interleukin-1beta; | 2023 |
Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model.
Topics: Animals; Female; Models, Theoretical; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Seizures | 2022 |
Adaptive Mossy Cell Circuit Plasticity after Status Epilepticus.
Topics: Adaptation, Physiological; Animals; Dentate Gyrus; Male; Mice; Mossy Fibers, Hippocampal; Parvalbumi | 2022 |
Adjudin prevents neuronal damage and neuroinflammation via inhibiting mTOR activation against pilocarpine-induced status epilepticus.
Topics: Animals; Hydrazines; Indazoles; Male; Mammals; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; | 2022 |
Adenosine Kinase Isoforms in the Developing Rat Hippocampus after LiCl/Pilocarpine Status Epilepticus.
Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Disease Models, Animal; Hippocampus; Pilocarp | 2022 |
Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Generalized; Hippocampus; Pilocarpin | 2022 |
Modafinil exerts anticonvulsive effects against lithium-pilocarpine-induced status epilepticus in rats: A role for tumor necrosis factor-α and nitric oxide signaling.
Topics: Animals; Humans; Lithium; Modafinil; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pilocarpine; Rats; | 2022 |
Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Glutamate-Ammonia Ligase; Glycogen; Mice; Pilocarp | 2022 |
Ameliorating effect of ketogenic diet on acute status epilepticus: Insights into biochemical and histological changes in rat hippocampus.
Topics: Animals; Diet, Ketogenic; Epilepsy; Female; Hippocampus; Pilocarpine; Rats; Status Epilepticus | 2022 |
Dopamine depletion in wistar rats with epilepsy.
Topics: Animals; Dopamine; Epilepsy; Male; Muscarinic Agonists; Oxidopamine; Pilocarpine; Rats; Rats, Wistar | 2022 |
Disrupted in Schizophrenia 1 Regulates Ectopic Neurogenesis in the Mouse Hilus After Pilocarpine-induced Status Epilepticus.
Topics: Animals; Dentate Gyrus; Hippocampus; Mice; Nerve Tissue Proteins; Neurogenesis; Neurons; Pilocarpine | 2022 |
Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mammals; Mice; Mossy Fibers, | 2022 |
Nuclear translocation of GluA2/ GAPDH promotes neurotoxicity after pilocarpine-induced epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Glyceraldehyde-3-Phosphate Dehydrogenases; Hippocampus; P | 2022 |
Bilateral optogenetic activation of inhibitory cells favors ictogenesis.
Topics: Animals; Epilepsy, Temporal Lobe; Mice; Optogenetics; Pilocarpine; Seizures; Status Epilepticus | 2022 |
The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation | 2022 |
Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Antineoplastic Agents; HMGB1 Protein; Inflammation; Mice; NF-kappa B; NF-KappaB Inhibitor a | 2023 |
Pentylenetetrazole preconditioning attenuates severity of status epilepticus induced by lithium-pilocarpine in male rats: evaluation of opioid/NMDA receptors and nitric oxide pathway.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Enzyme Inhibitors; Lithium; Male; N-Methylaspartate; N | 2022 |
Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain.
Topics: Animals; Brain; Epilepsy; Female; Hippocampus; Lithium; Membrane Glycoproteins; Nerve Tissue Protein | 2022 |
Regulation of Inflammation-Related Genes through
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Inflammation; Levetiracetam; Mice; Piloc | 2022 |
Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
Topics: Animals; Anticonvulsants; Cytokines; Disease Models, Animal; Encephalitis; Levetiracetam; Mice; Mono | 2022 |
Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammasomes; Interl | 2022 |
Effect of morphine administration after status epilepticus on epileptogenesis in rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Lithium; Morphine; Naloxone; Pilocarpine; Rats; Seizures; | 2022 |
Neuroprotective Effect of Exogenous Galectin-1 in Status Epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Galectin 1; Hippocampus; Neuroprotective A | 2022 |
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetraz | 2023 |
Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences.
Topics: Animals; Disease Models, Animal; Endurance Training; Epilepsy; Hippocampus; Humans; Pilocarpine; Rat | 2022 |
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway.
Topics: AMP-Activated Protein Kinases; Animals; Epilepsy; Lithium; Microglia; Oxidative Stress; Pilocarpine; | 2023 |
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway.
Topics: AMP-Activated Protein Kinases; Animals; Epilepsy; Lithium; Microglia; Oxidative Stress; Pilocarpine; | 2023 |
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway.
Topics: AMP-Activated Protein Kinases; Animals; Epilepsy; Lithium; Microglia; Oxidative Stress; Pilocarpine; | 2023 |
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway.
Topics: AMP-Activated Protein Kinases; Animals; Epilepsy; Lithium; Microglia; Oxidative Stress; Pilocarpine; | 2023 |
Anticonvulsant and antioxidant effects of lamotrigine on pilocarpine-induced status epilepticus in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Dizocilpine Maleate; Glutathione; Hippocampus; Lamotrigine; | 2023 |
Anticonvulsant and antioxidant effects of lamotrigine on pilocarpine-induced status epilepticus in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Dizocilpine Maleate; Glutathione; Hippocampus; Lamotrigine; | 2023 |
Anticonvulsant and antioxidant effects of lamotrigine on pilocarpine-induced status epilepticus in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Dizocilpine Maleate; Glutathione; Hippocampus; Lamotrigine; | 2023 |
Anticonvulsant and antioxidant effects of lamotrigine on pilocarpine-induced status epilepticus in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Dizocilpine Maleate; Glutathione; Hippocampus; Lamotrigine; | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
The vasodilator naftidrofuryl attenuates short-term brain glucose hypometabolism in the lithium-pilocarpine rat model of status epilepticus without providing neuroprotection.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Hippocampus; Humans; Lithium; Nafronyl; Neuroprotec | 2023 |
Arundic acid (ONO-2506) downregulates neuroinflammation and astrocyte dysfunction after status epilepticus in young rats induced by Li-pilocarpine.
Topics: Animals; Astrocytes; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; Neuroinflammatory Disea | 2023 |
Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model.
Topics: Animals; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Magnetic Fields; Piloca | 2023 |
Allopurinol and ellagic acid decrease epileptiform activity and the severity of convulsive behavior in a model of status epilepticus.
Topics: Allopurinol; Animals; Antioxidants; Ellagic Acid; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; S | 2023 |
Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Astrocytes; Connexin 43; Connexins; Down-Regulation; Hippocampus; Pilocarpine; Rats; RNA, M | 2022 |
Hippocampal glucocorticoid receptors modulate status epilepticus severity.
Topics: Animals; Convulsants; Corticosterone; Female; Glucocorticoids; Hippocampus; Male; Mice; Pilocarpine; | 2023 |
Preclinical pharmacokinetics and tolerability of a novel meglumine-based parenteral solution of topiramate and topiramate combinations for treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Fructose; Levetiracetam; Pilocarpine; Rats; Status Epilepticus; Topiramate | 2023 |
Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus.
Topics: Anti-Inflammatory Agents; Eugenol; Hippocampus; Humans; Inflammasomes; Neuroinflammatory Diseases; N | 2023 |
Interictal aggression in rats with chronic seizures after an early life episode of status epilepticus.
Topics: Aggression; Animals; Epilepsy; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epil | 2023 |
Deep brain stimulation suppresses epileptic seizures in rats via inhibition of adenosine kinase and activation of adenosine A1 receptors.
Topics: Adenosine Kinase; Animals; Disease Progression; Epilepsy; Male; Pilocarpine; Rats; Rats, Sprague-Daw | 2023 |
Thalidomide Attenuates Epileptogenesis and Seizures by Decreasing Brain Inflammation in Lithium Pilocarpine Rat Model.
Topics: Animals; Disease Models, Animal; Encephalitis; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Male; | 2023 |
Expression of Cytokines and Neurodegeneration in the Rat Hippocampus and Cortex in the Lithium-Pilocarpine Model of Status Epilepticus and the Role of Modulation of Endocannabinoid System.
Topics: Animals; Cytokines; Disease Models, Animal; Endocannabinoids; Hippocampus; Interleukin-6; Lithium; N | 2023 |
Optogenetic activation of septal inhibitory cells abates focal seizures.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mice; Optogenetics; Parvalbum | 2023 |
Alterations in the Properties of the Rat Hippocampus Glutamatergic System in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Pilocarpin | 2023 |
Reduction of vascular reactivity in rat aortas following pilocarpine-induced status epilepticus.
Topics: Animals; Aorta, Thoracic; Catalase; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine | 2023 |
Progressive Dysregulation of Tau Phosphorylation in an Animal Model of Temporal Lobe Epilepsy.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Mo | 2023 |
A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Flufen | 2023 |
Dynamic effects of miR-20a-5p on hippocampal ripple energy after status epilepticus in rats.
Topics: Animals; Chloral Hydrate; Hippocampus; MicroRNAs; Pilocarpine; Rats; Seizures; Status Epilepticus; V | 2023 |
Disrupted in Schizophrenia 1 Reverse Ectopic Migration of Neural Precursors in Mouse Hilus After Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Mice; Neurogenesis; Pilocarpine; Schizophrenia; Seizures; Status Epilepticus | 2023 |
Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Animals; CA2 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2023 |
Dendritic reorganization in the hippocampus, anterior temporal lobe, and frontal neocortex of lithium-pilocarpine induced Status Epilepticus (SE).
Topics: Animals; Disease Models, Animal; Hippocampus; Lithium; Neocortex; Pilocarpine; Rats; Status Epilepti | 2023 |
Effect of U50488, a selective kappa opioid receptor agonist and levetiracetam against lithium-pilocarpine-induced status epilepticus, spontaneous convulsive seizures and related cognitive impairment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 2023 |
N-Formyl-Methionyl-Leucyl-Phenylalanine Plays a Neuroprotective and Anticonvulsant Role in Status Epilepticus Model.
Topics: Animals; Anticonvulsants; Epilepsy; Male; N-Formylmethionine Leucyl-Phenylalanine; Peptides; Pilocar | 2023 |
EpiPro, a Novel, Synthetic, Activity-Regulated Promoter That Targets Hyperactive Neurons in Epilepsy for Gene Therapy Applications.
Topics: Animals; Disease Models, Animal; Epilepsy; Genetic Therapy; Hippocampus; Mice; Neurons; Pilocarpine; | 2023 |
Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Mefloquine; Neuropr | 2023 |
Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model.
Topics: Animals; Disease Models, Animal; Evidence-Based Practice; Hippocampus; Pilocarpine; Rats; Rats, Spra | 2019 |
Forced Physical Training Increases Neuronal Proliferation and Maturation with Their Integration into Normal Circuits in Pilocarpine Induced Status Epilepticus Mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; CpG Islands; Dentate Gyrus; DNA; DNA | 2019 |
Calpain-dependent cleavage of GABAergic proteins during epileptogenesis.
Topics: Animals; CA1 Region, Hippocampal; Calpain; Male; Membrane Proteins; Neurons; Pilocarpine; Rats; Rats | 2019 |
Status Epilepticus Increases Cell Proliferation and Neurogenesis in the Developing Rat Cerebellum.
Topics: Animals; Cell Proliferation; Cerebellum; Female; Lithium Chloride; Male; Neurogenesis; Pentylenetetr | 2020 |
Systemic thrombin inhibition ameliorates seizures in a mouse model of pilocarpine-induced status epilepticus.
Topics: Animals; Anticoagulants; Disease Models, Animal; Hippocampus; Male; Mice; Pilocarpine; Pyrroles; Qui | 2019 |
Modulatory effect of opioid ligands on status epilepticus and the role of nitric oxide pathway.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Indazoles; Ligands; | 2019 |
Disentangling chemical and electrical effects of status epilepticus-induced dentate gyrus abnormalities.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Hippocampus; Mice; Neurogenesis; Pilocarpine; Status | 2021 |
Effects of Diazepam and Ketamine on Pilocarpine-Induced Status Epilepticus in Mice.
Topics: Animals; Anticonvulsants; Diazepam; Electroencephalography; Hippocampus; Ketamine; Mice; Pilocarpine | 2019 |
Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Kainic Acid; Male; Mitochondria; Mitophagy; | 2020 |
Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.
Topics: Animals; B7-2 Antigen; Brain Chemistry; Cell Polarity; Convulsants; Cytokines; Inflammation; Male; M | 2019 |
The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats.
Topics: Animals; Catalase; Disease Models, Animal; Histamine H3 Antagonists; Male; Neuroprotective Agents; P | 2019 |
Neuroprotective effects and improvement of learning and memory elicited by erythravine and 11α-hydroxy-erythravine against the pilocarpine model of epilepsy.
Topics: Alkaloids; Animals; Convulsants; Epilepsy; Heterocyclic Compounds, 4 or More Rings; Hippocampus; Imm | 2020 |
Long-term effects of status epilepticus during infancy in male rats: Sexual behavior and brain response upon exposure to sexually receptive females.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Corticosterone; Female; Male; Pilocarpine; Rats; Rats | 2020 |
Alteration of Gene Associated with Retinoid-interferon-induced Mortality-19-expressing Cell Types in the Mouse Hippocampus Following Pilocarpine-induced Status Epilepticus.
Topics: Animals; Astrocytes; Disease Models, Animal; Hippocampus; Interferons; Male; Mice, Inbred C57BL; Mic | 2020 |
Aberrant Connectivity During Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Brain Waves; Connectome; Disease Models, Animal; Electrocorticography; Epilepsy, Temporal L | 2020 |
The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Epilepsy; Hippocampus; Lithium Chloride; Neur | 2020 |
Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus.
Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Electroencephalography; Male; M | 2020 |
Ryanodine receptors drive neuronal loss and regulate synaptic proteins during epileptogenesis.
Topics: Animals; Calcium; Calcium Channel Blockers; Dantrolene; Hippocampus; Male; Neurons; Neuroprotective | 2020 |
Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model.
Topics: Adolescent; Adult; Animals; Anti-Inflammatory Agents; Convulsants; Cytokines; Encephalitis; Epilepsy | 2020 |
Neuroprotective effects of thromboxane receptor antagonist SQ 29,548 after pilocarpine-induced status epilepticus in mice.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Fatty Acids, Unsaturated; | 2020 |
Daytime-restricted feeding modulates the expression of inflammatory mediators and diminishes reactive astrogliosis and microgliosis following status epilepticus.
Topics: Animals; Brain; Fasting; Gene Expression; Gliosis; Inflammation Mediators; Male; Microglia; Pilocarp | 2020 |
The polarity and properties of radial glia-like neural stem cells are altered by seizures with status epilepticus: Study using an improved mouse pilocarpine model of epilepsy.
Topics: Animals; Cell Polarity; Disease Models, Animal; Ependymoglial Cells; Mice; Neural Stem Cells; Neurog | 2020 |
Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice.
Topics: Aggression; Animals; Cell Proliferation; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; | 2020 |
Propofol inhibited apoptosis of hippocampal neurons in status epilepticus through miR-15a-5p/NR2B/ERK1/2 pathway.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Down-Regulati | 2020 |
Altered expression of parvalbumin immunoreactivity in rat main olfactory bulb following pilocarpine-induced status epilepticus.
Topics: Animals; Dendrites; Disease Models, Animal; Interneurons; Male; Neurons; Olfactory Bulb; Parvalbumin | 2020 |
TRPV1 Contributes to the Neuroprotective Effect of Dexmedetomidine in Pilocarpine-Induced Status Epilepticus Juvenile Rats.
Topics: Animals; Apoptosis; Calcium; Caspase 3; Dexmedetomidine; Disease Models, Animal; Male; Membrane Pote | 2020 |
Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice.
Topics: Animals; Antagomirs; Apoptosis; Cell Death; Disease Models, Animal; Down-Regulation; Male; Mice, Inb | 2020 |
The P2X7 receptor in activated microglia promotes depression- and anxiety-like behaviors in lithium -pilocarpine induced epileptic rats.
Topics: Animals; Anxiety; Depression; Lithium; Male; Microglia; Pilocarpine; Purinergic P2X Receptor Antagon | 2020 |
Withanolide-A treatment exerts a neuroprotective effect via inhibiting neuroinflammation in the hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Hippocampus; Male; Mice, Inbred C57BL; Neuroprotection; Neuroprotec | 2020 |
2-Deoxyglucose terminates pilocarpine-induced status epilepticus in neonatal rats.
Topics: Animals; Animals, Newborn; Antimetabolites; Deoxyglucose; Electroencephalography; Muscarinic Agonist | 2020 |
Loss of Protection by Antiepileptic Drugs in Lipopolysaccharide-primed Pilocarpine-induced Status Epilepticus is Mediated via Inflammatory Signalling.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Pil | 2020 |
Modulation of neuropathology and cognitive deficits by lipopolysaccharide preconditioning in a mouse pilocarpine model of status epilepticus.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Lipopolysaccharides; Locomotion; Male; Mice; | 2020 |
Effects of Dexamethasone on Remodeling of the Hippocampal Synaptic Filamentous Actin Cytoskeleton in a Model of Pilocarpine-induced Status Epilepticus.
Topics: Actin Cytoskeleton; Actins; Animals; Dexamethasone; Disease Models, Animal; Hippocampus; Humans; Mic | 2020 |
Identification of microRNA-target genes in mice hippocampus at 1 week after pilocarpine-induced status epilepticus.
Topics: Animals; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Hippocampus; Mice; Mi | 2020 |
Vascular endothelial growth factor receptor-3 regulates astroglial glutamate transporter-1 expression via mTOR activation in reactive astrocytes following pilocarpine-induced status epilepticus.
Topics: Amino Acid Transport System X-AG; Astrocytes; Excitatory Amino Acid Transporter 2; Hippocampus; Huma | 2021 |
Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility.
Topics: Animals; Brain; Hippocampus; Mice; Pilocarpine; Seizures; Status Epilepticus | 2022 |
Role of Modulation of Hippocampal Glucose Following Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Antioxidants; Biomarkers; Cell Death; Glucose; Hippocampus; Male; Memory Consolidation; Neu | 2021 |
The efficacy of fructose-1,6-bisphosphate in suppressing status epilepticus in developing rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Fructose; Hippocampus; Pil | 2020 |
Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; Equilibrative Nucleoside Transporter 1; Glutamic Acid; Hi | 2020 |
Rosiglitazone Prevents Autophagy by Regulating Nrf2-Antioxidant Response Element in a Rat Model of Lithium-pilocarpine-induced Status Epilepticus.
Topics: Animals; Antioxidant Response Elements; Autophagy; Lithium; Male; NF-E2-Related Factor 2; Oxidative | 2021 |
Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Blood Glucose; Disease Models, Animal; Drug Resistant Epilepsy; Female; Hi | 2020 |
Status epilepticus induced Gadd45b is required for augmented dentate neurogenesis.
Topics: Animals; Antigens, Differentiation; Dentate Gyrus; Epigenesis, Genetic; Hippocampus; Mice; Neurogene | 2020 |
Time course evaluation of lacosamide alone and in polypharmacy on behavioral manifestations and oxidative stress in lithium-pilocarpine-induced model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biomarkers; Brain; Disease Models, Animal; Drug Therapy, | 2020 |
Roles of Very Fast Ripple (500-1000[Formula: see text]Hz) in the Hippocampal Network During Status Epilepticus.
Topics: Animals; Brain Waves; Epilepsy, Temporal Lobe; Hippocampus; Pilocarpine; Rats; Status Epilepticus | 2021 |
Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission.
Topics: Animals; Anticonvulsants; Benzyl Alcohols; Disease Models, Animal; Electroencephalography; Epilepsy, | 2021 |
Protein disulfide isomerase-mediated S-nitrosylation facilitates surface expression of P2X7 receptor following status epilepticus.
Topics: Animals; Enzyme Inhibitors; Gene Expression; Infusions, Intraventricular; Male; NG-Nitroarginine Met | 2021 |
A Novel Second-Generation EP2 Receptor Antagonist Reduces Neuroinflammation and Gliosis After Status Epilepticus in Rats.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Gliosis; Humans; Inflammation Mediators; Male; | 2021 |
The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model.
Topics: Animals; Anticonvulsants; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2020 |
LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroencephalography; GABA-A Receptor Ant | 2021 |
Maternal crack cocaine use in rats leads to depressive- and anxiety-like behavior, memory impairment, and increased seizure susceptibility in the offspring.
Topics: Animals; Anxiety; Cocaine-Related Disorders; Crack Cocaine; Epilepsy; Female; Male; Memory Disorders | 2021 |
Effects of acute seizures on cell proliferation, synaptic plasticity and long-term behavior in adult zebrafish.
Topics: Animals; Behavior, Animal; Cell Proliferation; Hippocampus; Neurogenesis; Neuronal Plasticity; Piloc | 2021 |
Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structure-activity relationship and biological activity as potential antitumor and anticonvulsant agents.
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Cell Surv | 2021 |
Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation.
Topics: Animals; Anticonvulsants; Biomarkers; Hippocampus; Inflammation; Interleukin-1beta; Lacosamide; Male | 2021 |
LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus.
Topics: Animals; ATP-Dependent Proteases; CA1 Region, Hippocampal; Caspase 3; Cell Death; Gene Knockdown Tec | 2021 |
Enriched environment ameliorates chronic temporal lobe epilepsy-induced behavioral hyperexcitability and restores synaptic plasticity in CA3-CA1 synapses in male Wistar rats.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Calbindins; Environment; Epilepsy, Tempor | 2021 |
Citral Effects on the Expression Profile of
Topics: Acyclic Monoterpenes; Animals; Brain-Derived Neurotrophic Factor; Cytokines; Disease Models, Animal; | 2021 |
The glucocorticoid receptor specific modulator CORT108297 reduces brain pathology following status epilepticus.
Topics: Animals; Aza Compounds; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; H | 2021 |
Excitatory synaptic transmission in hippocampal area CA1 is enhanced then reduced as chronic epilepsy progresses.
Topics: Animals; CA1 Region, Hippocampal; Chronic Disease; Disease Progression; Epilepsy; Excitatory Postsyn | 2021 |
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
Topics: Animals; Astrocytes; Calcium Signaling; Disease Models, Animal; Disease Progression; Disease Suscept | 2021 |
The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus.
Topics: Animals; Antioxidants; Apoptosis; Dose-Response Relationship, Drug; Fullerenes; Gene Expression Regu | 2021 |
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Diazepam; Hippocampus; Isoflurophate; Male; Neurons | 2021 |
Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antioxidants; Behavior, Animal; D | 2021 |
Limbic progesterone receptor activity enhances neuronal excitability and seizures.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Neurons; Pilocarpine; Progesterone; | 2021 |
Fructose 1,6-bisphosphate is anticonvulsant and improves oxidative glucose metabolism within the hippocampus and liver in the chronic pilocarpine mouse epilepsy model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Fructose; Fructosediphosphates; Glucose; | 2021 |
Sex-related Differences in Glial Fibrillary Acidic Protein-positive GABA Regulate Neuropathology Following Pilocarpine-induced Status Epilepticus.
Topics: Animals; Female; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Hippocampus; Male; Mice; | 2021 |
VEGF treatment during status epilepticus attenuates long-term seizure-associated alterations in astrocyte morphology.
Topics: Animals; Astrocytes; Cells, Cultured; Dentate Gyrus; Hippocampus; Male; Pilocarpine; Rats; Rats, Spr | 2017 |
Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Cognition Disorders; Disease Models, Animal; Gene | 2017 |
Reduced abnormal integration of adult-generated granule cells does not attenuate spontaneous recurrent seizures in mice.
Topics: Animals; Bromodeoxyuridine; Cell Count; Disease Models, Animal; Doublecortin Domain Proteins; Female | 2017 |
NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Mode | 2017 |
Phase-Dependent Astroglial Alterations in Li-Pilocarpine-Induced Status Epilepticus in Young Rats.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Lithium; Nerve De | 2017 |
Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice.
Topics: Animals; Antibodies, Monoclonal; Blood-Brain Barrier; Cerebral Cortex; Female; Hippocampus; HMGB1 Pr | 2017 |
Complex modulation by stress of the effect of seizures on long term potentiation in mouse hippocampal slices.
Topics: Animals; Anticonvulsants; Atropine; Corticosterone; Diazepam; Disease Models, Animal; Electric Stimu | 2017 |
Neurosteroid-sensitive δ-GABA
Topics: Animals; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; Down-Regulat | 2017 |
Simultaneous triple therapy for the treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Brain Waves; Combined Modality Therapy; Disease Models, Animal; Dose-Respo | 2017 |
Oxidative Stress Contributes to Status Epilepticus Associated Mortality.
Topics: Animals; Anticonvulsants; Antioxidants; Hippocampus; Male; Oxidative Stress; Pilocarpine; Rats; Rats | 2017 |
Involvement of microRNA-146a in the Inflammatory Response of S tatus Epilepticus Rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Cytokines; Disease Models, Animal; Gene Expression Regulati | 2017 |
TRPC6-mediated ERK1/2 phosphorylation prevents dentate granule cell degeneration via inhibiting mitochondrial elongation.
Topics: Animals; Butadienes; Disease Models, Animal; Dynamins; Enzyme Inhibitors; Male; Mitochondria; Mitoch | 2017 |
Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model.
Topics: Animals; Astrocytes; Autoradiography; Brain; Carbazoles; Carrier Proteins; Disease Models, Animal; E | 2017 |
4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid attenuates spontaneous recurrent seizures and vasogenic edema following lithium-pilocarpine induced status epilepticus.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anticonvulsants; Apoptosis; Blood-Brain B | 2017 |
The Role of 5-HTR6 in Mossy Fiber Sprouting: Activating Fyn and p-ERK1/2 in Pilocarpine-Induced Chronic Epileptic Rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Flavonoids; GAP-43 Protein; Male; Mitogen-Activated Prote | 2017 |
Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus.
Topics: Animals; Chronic Disease; Circadian Rhythm; Cluster Analysis; Disease Models, Animal; Electroencepha | 2017 |
A systems level analysis of epileptogenesis-associated proteome alterations.
Topics: Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Female; Gene Regulatory Networks; Mu | 2017 |
The neuroprotective effect of perampanel in lithium-pilocarpine rat seizure model.
Topics: Animals; Anticonvulsants; Antigens, Nuclear; Brain; Cell Death; Diazepam; Dose-Response Relationship | 2017 |
Plasticity of intrinsic firing response gain in principal hippocampal neurons following pilocarpine-induced status epilepticus.
Topics: Action Potentials; Animals; Disease Models, Animal; Hippocampus; Male; Neuronal Plasticity; Neurons; | 2017 |
HMGB1 regulates P-glycoprotein expression in status epilepticus rat brains via the RAGE/NF-κB signaling pathway.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Gene Expression Regulation; | 2017 |
EP2 receptor agonist ONO-AE1-259-01 attenuates pentylenetetrazole- and pilocarpine-induced seizures but causes hippocampal neurotoxicity.
Topics: Animals; Anticonvulsants; Dinoprostone; Hippocampus; Male; Mice; Neurons; Neurotoxicity Syndromes; P | 2017 |
Increased gyrification and aberrant adult neurogenesis of the dentate gyrus in adult rats.
Topics: Analysis of Variance; Animals; Atropine Derivatives; Bicuculline; Bromodeoxyuridine; Dentate Gyrus; | 2017 |
Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Lamotrigi | 2017 |
Time-dependent evolution of seizures in a model of mesial temporal lobe epilepsy.
Topics: Animals; Brain Waves; Disease Models, Animal; Disease Progression; Electrocorticography; Entorhinal | 2017 |
The role of necroptosis in status epilepticus-induced brain injury in juvenile rats.
Topics: Amygdala; Animals; Biomarkers; Brain Injuries; Cognitive Dysfunction; Lithium; Male; Necrosis; Neuro | 2017 |
Effect of diet with omega-3 in basal brain electrical activity and during status epilepticus in rats.
Topics: Animals; Brain; Cell Death; Dietary Supplements; Disease Models, Animal; Electrocorticography; Elect | 2017 |
An alkaloid extract obtained from Phlegmariurus Saururus induces neuroprotection after status epilepticus.
Topics: Animals; Apoptosis; Astrocytes; Cell Death; Cells, Cultured; Coculture Techniques; Disease Models, A | 2017 |
Involvement of nitrergic system in anticonvulsant effect of zolpidem in lithium-pilocarpine induced status epilepticus: Evaluation of iNOS and COX-2 genes expression.
Topics: Animals; Anticonvulsants; Arginine; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Interac | 2017 |
Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy.
Topics: Animals; Complement C1q; Complement C3; Epilepsy; Hippocampus; Male; Pilocarpine; Rats, Sprague-Dawl | 2018 |
The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus.
Topics: Analysis of Variance; Animals; Disease Models, Animal; G-Protein-Coupled Receptor Kinase 5; Hippocam | 2017 |
Epileptic pilocarpine-treated rats exhibit aberrant hippocampal EPSP-spike potentiation but retain long-term potentiation.
Topics: Action Potentials; Animals; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Postsynaptic P | 2017 |
Intracerebroventricular injection of miR-146a relieves seizures in an immature rat model of lithium-pilocarpine induced status epilepticus.
Topics: Animals; Antagomirs; Disease Models, Animal; Hippocampus; Inflammation; Lithium Compounds; Male; Mic | 2018 |
Mycophenolate mofetil prevents the delayed T cell response after pilocarpine-induced status epilepticus in mice.
Topics: Animals; Immunophenotyping; Mice; Mice, Inbred C57BL; Mycophenolic Acid; Pilocarpine; Reverse Transc | 2017 |
Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Cerebral Cortex; Cognition Disorders; Convulsants; | 2018 |
Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Citric Acid Cycle; Convu | 2018 |
Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression.
Topics: Animals; Disease Models, Animal; Disease Progression; Electroencephalography; Female; Hippocampus; M | 2017 |
Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats?
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain Waves; Cerebral Cortex; Disease Model | 2018 |
The effects of calcineurin inhibitor FK506 on actin cytoskeleton, neuronal survival and glial reactions after pilocarpine-induced status epilepticus in mice.
Topics: Actin Cytoskeleton; Actins; Animals; Anticonvulsants; Calcineurin Inhibitors; Calcium-Binding Protei | 2018 |
Antagonist targeting microRNA-146a protects against lithium-pilocarpine-induced status epilepticus in rats by nuclear factor-κB pathway.
Topics: Animals; Biomarkers; Cytokines; Gene Expression; Hippocampus; Inflammation Mediators; Lithium; Male; | 2018 |
Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy.
Topics: Animals; Apoptosis; Disease Models, Animal; Ectopic Gene Expression; Epilepsy; Hippocampus; Male; Mi | 2018 |
The differential roles of PEA15 phosphorylations in reactive astrogliosis and astroglial apoptosis following status epilepticus.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Astrocytes; Benzylamines; Fluorescent Antibody Te | 2018 |
Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Electroencephalography; Male; Muscarinic Agonists; Pilocarpine; Rat | 2018 |
Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus.
Topics: Animals; Disease Models, Animal; Glutamate Decarboxylase; Green Fluorescent Proteins; Hippocampus; I | 2018 |
Cx36 in the mouse hippocampus during and after pilocarpine-induced status epilepticus.
Topics: Animals; Connexins; Gap Junction delta-2 Protein; Gene Expression Regulation; Hippocampus; Male; Mic | 2018 |
Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis.
Topics: Animals; Atorvastatin; Convulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy; Female; Male; M | 2018 |
Ablation of aberrant neurogenesis fails to attenuate cognitive deficit of chronically epileptic mice.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Cognition Disorders; Disease Models, Animal; Doublec | 2018 |
Memantine decreases neuronal degeneration in young rats submitted to LiCl-pilocarpine-induced status epilepticus.
Topics: Animals; Brain; Excitatory Amino Acid Antagonists; Female; Lithium Chloride; Male; Memantine; Neuron | 2018 |
RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice, Inbred C57 | 2018 |
Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Blood Glucose; Convulsants; Cytokines | 2018 |
Clustering of spontaneous recurrent seizures separated by long seizure-free periods: An extended video-EEG monitoring study of a pilocarpine mouse model.
Topics: Animals; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Male; Mi | 2018 |
Neuroprotective effect of curcumin nanoparticles against rat model of status epilepticus induced by pilocarpine.
Topics: Animals; Antioxidants; Curcuma; Curcumin; Disease Models, Animal; Lipid Peroxidation; Male; Nanopart | 2018 |
Folate homeostasis in epileptic rats.
Topics: Animals; Brain; CD11b Antigen; Convulsants; Disease Models, Animal; Folate Receptor 1; Folic Acid; G | 2018 |
Status epilepticus: Role for etiology in determining response to benzodiazepines.
Topics: Animals; Benzodiazepines; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; | 2018 |
Acute Changes in Electrophysiological Properties of Cortical Regular-Spiking Cells Following Seizures in a Rat Lithium-Pilocarpine Model.
Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Lithium Compounds; Membrane Potentials; Models, | 2018 |
A novel online fluorescence method for in-vivo measurement of hydrogen peroxide during oxidative stress produced in a temporal lobe epilepsy model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hydrogen Peroxide; | 2018 |
Profiles of gene expression in the hippocampal formation of rats with experimentally-induced brain dysplasia.
Topics: Animals; Electroshock; Hippocampus; Male; Malformations of Cortical Development; Microarray Analysis | 2018 |
Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin.
Topics: Animals; Behavior, Animal; Cation Transport Proteins; Cerebral Cortex; Disease Models, Animal; Femal | 2019 |
Increased Superoxide Dismutase 2 by Allopregnanolone Ameliorates ROS-Mediated Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Pilocarpine; Pregnanolone | 2018 |
The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Bromocriptine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combi | 2019 |
Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice.
Topics: Amygdala; Animals; Apoptosis; Astrocytes; Cell Death; Cell Nucleus; Gene Expression; Hippocampus; In | 2018 |
Inverted-U response of lacosamide on pilocarpine-induced status epilepticus and oxidative stress in C57BL/6 mice is independent of hippocampal collapsin response mediator protein-2.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Beha | 2018 |
Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus.
Topics: Amantadine; Animals; Astrocytes; Behavior, Animal; Caspase 3; Cell Survival; Cognition Disorders; Di | 2019 |
A Hydroxypyrone-Based Inhibitor of Metalloproteinase-12 Displays Neuroprotective Properties in Both
Topics: Animals; CA3 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Enzyme Inhibitors; Humans; | 2018 |
Effects of gap junctions blockers on fast ripples and connexin in rat hippocampi after status epilepticus.
Topics: Animals; Anticonvulsants; Carbenoxolone; Connexins; Electrocorticography; Gap Junctions; Gene Expres | 2018 |
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.
Topics: ADAM10 Protein; Amyloid Precursor Protein Secretases; Animals; Calcium-Binding Proteins; Cyclooxygen | 2018 |
Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice.
Topics: Animals; Apoptosis; Cell Polarity; Cytokines; Disease Models, Animal; Female; Gene Expression Regula | 2018 |
Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden and prevents status epilepticus-induced neuronal death and epileptogenesis.
Topics: Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Female; Gene Exp | 2018 |
Protective Role of UCP2 in Oxidative Stress and Apoptosis during the Silent Phase of an Experimental Model of Epilepsy Induced by Pilocarpine.
Topics: Animals; Apoptosis; Disease Models, Animal; Male; Oxidative Stress; Pilocarpine; Rats; Rats, Wistar; | 2018 |
[CHANGES IN BRAIN ELECTRICAL ACTIVITY PATTERNS IN RATS WITH DIFFERENT SUSCEPTIBILITY TO SEIZURES IN LITHIUM-PILOCARPINE MODEL OF STATUS EPILEPTICUS].
Topics: Animals; Brain; Electroencephalography; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Status Epile | 2016 |
Neuroprotective effects of levetiracetam, both alone and combined with propylparaben, in the long-term consequences induced by lithium-pilocarpine status epilepticus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Hippocampus; Levetiracetam; Lith | 2018 |
Oral administration of the casein kinase 2 inhibitor TBB leads to persistent K
Topics: Administration, Oral; Animals; Anticonvulsants; CA1 Region, Hippocampal; Casein Kinase II; Disease M | 2018 |
Can a hypercholesterolemic diet change the basal brain electrical activity and during status epilepticus in rats?
Topics: Animals; Brain; Cholesterol; Diet, High-Fat; Disease Models, Animal; Electroencephalography; Male; P | 2019 |
The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures.
Topics: Action Potentials; Animals; Cell Differentiation; Cell Line; Disease Models, Animal; Glatiramer Acet | 2018 |
Chemical biomarkers of epileptogenesis and ictogenesis in experimental epilepsy.
Topics: Animals; Biomarkers; Brain; Convulsants; Disease Models, Animal; Extracellular Space; Male; Pilocarp | 2019 |
The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus.
Topics: Animals; Apoptosis; Disease Models, Animal; Hippocampus; Male; Necrosis; Neurons; Pilocarpine; Rando | 2018 |
Differential expression of synaptic vesicle protein 2A after status epilepticus and during epilepsy in a lithium-pilocarpine model.
Topics: Animals; Disease Models, Animal; Gene Expression; Hippocampus; Lithium Chloride; Male; Membrane Glyc | 2018 |
Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2019 |
Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Glycyrrhizic Acid; Hippocampus; HMG | 2019 |
Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; GABA-B Receptor Antagon | 2019 |
Early Aberrant Growth of Mossy Fibers after Status Epilepticus in the Immature Rat Brain.
Topics: Animals; Animals, Newborn; Female; Male; Mossy Fibers, Hippocampal; Neurogenesis; Neuronal Plasticit | 2019 |
Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Brugada Syndrome; Disease Models, Animal; Epilepsy, Tem | 2019 |
Intravenously Administered Ganaxolone Blocks Diazepam-Resistant Lithium-Pilocarpine-Induced Status Epilepticus in Rats: Comparison with Allopregnanolone.
Topics: Administration, Intravenous; Anesthetics; Animals; Anticonvulsants; Diazepam; Drug Resistant Epileps | 2019 |
Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cannabidiol; Disease Models, Animal; Epilepsy; Epilepsy, | 2019 |
Catalpol Exerts an Anti-Epilepticus Effect, Possibly by Regulating the Nrf2-Keap1-ARE Signaling Pathway.
Topics: Animals; China; Disease Models, Animal; Epilepsy; Iridoid Glucosides; Kelch-Like ECH-Associated Prot | 2018 |
The Effects of Minocycline on the Hippocampus in Lithium- Pilocarpine Induced Status Epilepticus in Rat: Relations with Microglial/Astrocytic Activation and Serum S100B Level.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Biomarkers; Convulsants; Disease Models, Animal; Hipp | 2019 |
The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity.
Topics: Animals; Blood Glucose; Blood-Brain Barrier; Hippocampus; Ion Channel Gating; Mice, Inbred C57BL; Ne | 2019 |
Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model.
Topics: Animals; Anticonvulsants; Benzoxazines; Disease Models, Animal; Endocannabinoids; Hippocampus; Lithi | 2019 |
Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment.
Topics: Animals; COP9 Signalosome Complex; Intracellular Signaling Peptides and Proteins; Maze Learning; Mem | 2019 |
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; | 2019 |
The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2019 |
The Neuroprotective Effect of
Topics: Animals; Basidiomycota; Cell Death; Disease Models, Animal; Hippocampus; Humans; Mice; Neurons; Neur | 2019 |
Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.
Topics: Animals; Calcium Channels; Disease Models, Animal; Early Growth Response Protein 1; Epilepsy, Tempor | 2019 |
Anticonvulsant and Neuroprotective Effects of Dexmedetomidine on Pilocarpine-Induced Status Epilepticus in Rats Using a Metabolomics Approach.
Topics: Animals; Anticonvulsants; Brain; Chromatography, Liquid; Dexmedetomidine; Disease Models, Animal; Hi | 2019 |
Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy.
Topics: Animals; Anticonvulsants; Brain Waves; Diazepam; Disease Models, Animal; Drug Combinations; Electroe | 2019 |
Targeting PSD95-nNOS interaction by Tat-N-dimer peptide during status epilepticus is neuroprotective in MAM-pilocarpine rat model.
Topics: Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; Female; Methylazoxymethanol Acetate; | 2019 |
MicroRNA-146a-5p Downregulates the Expression of P-Glycoprotein in Rats with Lithium-Pilocarpine-Induced Status Epilepticus.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cerebral Cortex; Down-Regulation; | 2019 |
Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus.
Topics: Animals; Apoptosis; CA1 Region, Hippocampal; Cognition Disorders; Disease Models, Animal; Hydrogen; | 2019 |
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.
Topics: Animals; Astrocytes; Epilepsy, Temporal Lobe; Inflammasomes; Inflammation; Leucine; Male; Mice; Mice | 2019 |
Impairments in cognitive functions and emotional and social behaviors in a rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anxiety; Behavior, Animal; Cognition; Emotions; Epilepsy; Epilepsy, Temporal Lobe; Explorat | 2019 |
Transient receptor potential vanilloid 4 is involved in the upregulation of connexin expression following pilocarpine-induced status epilepticus in mice.
Topics: Animals; Connexin 43; Connexins; Epilepsy; Gap Junction beta-1 Protein; Hippocampus; Leucine; Male; | 2019 |
Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model.
Topics: Animals; Astrocytes; Brain; Depression; Depressive Disorder; Disease Models, Animal; Epilepsy; Epoxi | 2019 |
Targeting Seizure-Induced Neurogenesis in a Clinically Relevant Time Period Leads to Transient But Not Persistent Seizure Reduction.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Male; Mice; Neural Stem Cells; Neu | 2019 |
Hippocampal CA1 and cortical interictal oscillations in the pilocarpine model of epilepsy.
Topics: Animals; Brain Waves; CA1 Region, Hippocampal; Cerebral Cortex; Cortical Synchronization; Epilepsy; | 2019 |
Progesterone receptor activation regulates seizure susceptibility.
Topics: Animals; Female; Mifepristone; Norprogesterones; Pilocarpine; Progesterone; Rats; Rats, Sprague-Dawl | 2019 |
Changes in excitatory and inhibitory receptor expression and network activity during induction and establishment of epilepsy in the rat Reduced Intensity Status Epilepticus (RISE) model.
Topics: Animals; Disease Models, Animal; Epilepsy; GluK2 Kainate Receptor; Hippocampus; Muscarinic Agonists; | 2019 |
Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility.
Topics: Animals; Anticonvulsants; Behavior, Animal; Databases, Genetic; Electroencephalography; Enzyme Inhib | 2013 |
Enhanced synaptic connectivity in the dentate gyrus during epileptiform activity: network simulation.
Topics: Algorithms; Computer Simulation; Dentate Gyrus; Electrophysiological Phenomena; Epilepsy; Humans; In | 2013 |
One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death.
Topics: Animals; Cell Death; Diazepam; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Mossy Fibers, H | 2013 |
The antiepileptic effect of the glycolytic inhibitor 2-deoxy-D-glucose is mediated by upregulation of K(ATP) channel subunits Kir6.1 and Kir6.2.
Topics: Animals; Anticonvulsants; Deoxyglucose; Glycolysis; Hippocampus; KATP Channels; Male; Mice; Mice, In | 2013 |
The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus.
Topics: Animals; Behavior, Animal; Cell Death; Diazepam; Disease Models, Animal; Drug Therapy, Combination; | 2013 |
AMPA receptor properties are modulated in the early stages following pilocarpine-induced status epilepticus.
Topics: Animals; CA3 Region, Hippocampal; Cerebral Cortex; Dentate Gyrus; Disease Progression; Excitatory Po | 2013 |
Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.
Topics: Animals; Dendrites; Dendritic Spines; Disease Models, Animal; Electroencephalography; Gliosis; Hippo | 2013 |
Changes in gene expression in the frontal cortex of rats with pilocarpine-induced status epilepticus after sleep deprivation.
Topics: Amidohydrolases; Analysis of Variance; Angiotensin-Converting Enzyme 2; Animals; Catalase; Disease M | 2013 |
Increased susceptibility to acetylcholine in the entorhinal cortex of pilocarpine-treated rats involves alterations in KCNQ channels.
Topics: Acetylcholine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Entorhinal Cortex; Evoke | 2013 |
Expressions of tumor necrosis factor alpha and microRNA-155 in immature rat model of status epilepticus and children with mesial temporal lobe epilepsy.
Topics: Adolescent; Animals; Astrocytes; Case-Control Studies; Child; Epilepsy, Temporal Lobe; Female; Hippo | 2013 |
A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Behavior, Animal; Brain; Carbamates; Cell Count; Dis | 2013 |
Trichosanthes tricuspidata modulates oxidative toxicity in brain hippocampus against pilocarpine induced status epilepticus in mice.
Topics: Animals; Cucurbitaceae; Gas Chromatography-Mass Spectrometry; Hippocampus; Male; Mice; Oxidative Str | 2013 |
Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cells, Cultured; Claudin-5; Disease Models, An | 2013 |
Differences in the hippocampal frequency of creatine inclusions between the acute and latent phases of pilocarpine model defined using synchrotron radiation-based FTIR microspectroscopy.
Topics: Animals; Behavior, Animal; Brain Mapping; Creatine; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2013 |
Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Deep Brain Stimulation; Diazepam; Diseas | 2013 |
Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus.
Topics: Animals; Cell Death; Dentate Gyrus; Disease Models, Animal; Granulins; Hippocampus; Intercellular Si | 2013 |
Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Hippocampus; Lithium; Nerve Degeneration; Piloc | 2013 |
The PPARγ agonist rosiglitazone prevents neuronal loss and attenuates development of spontaneous recurrent seizures through BDNF/TrkB signaling following pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Electroencephalography; Enzyme-Linked I | 2013 |
Plasticity at axon initial segment of hippocampal CA3 neurons in rat after status epilepticus induced by lithium-pilocarpine.
Topics: Action Potentials; Animals; Axons; Hippocampus; Lithium Compounds; Male; Neuronal Plasticity; Piloca | 2013 |
A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons.
Topics: Animals; Axons; Dendrites; Dentate Gyrus; GABAergic Neurons; Hippocampus; Interneurons; Mice; Mice, | 2013 |
Protective but not anticonvulsant effects of ghrelin and JMV-1843 in the pilocarpine model of Status epilepticus.
Topics: Animals; Corpus Striatum; Endothelin-1; Gene Expression Regulation; Ghrelin; Glial Fibrillary Acidic | 2013 |
The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Neuro | 2013 |
The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy.
Topics: Animals; Brain; Cell Death; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Hippocamp | 2014 |
STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy.
Topics: Animals; Behavior, Animal; Cells, Cultured; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Aci | 2013 |
Effect of lithium-pilocarpine-induced status epilepticus on ultrasonic vocalizations in the infant rat pup.
Topics: Age Factors; Animals; Animals, Newborn; Chi-Square Distribution; Convulsants; Disease Models, Animal | 2014 |
Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus.
Topics: Amines; Animals; Astrocytes; Cyclohexanecarboxylic Acids; Electroencephalography; Gabapentin; gamma- | 2013 |
Activation of group 2 metabotropic glutamate receptors reduces behavioral and electrographic correlates of pilocarpine induced status epilepticus.
Topics: Acute Disease; Amino Acids; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Down | 2014 |
Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizures.
Topics: Animals; Insufflation; Male; Mossy Fibers, Hippocampal; Oxygen; Pilocarpine; Random Allocation; Rats | 2014 |
Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Brain Injuries; Cerebral Cortex; Dexamethasone; Dise | 2014 |
Genetic deletion of the neuronal glutamate transporter, EAAC1, results in decreased neuronal death after pilocarpine-induced status epilepticus.
Topics: Animals; CA1 Region, Hippocampal; Cell Death; Convulsants; Excitatory Amino Acid Transporter 3; Gene | 2014 |
Early transplantation of bone marrow mononuclear cells promotes neuroprotection and modulation of inflammation after status epilepticus in mice by paracrine mechanisms.
Topics: Animals; Base Sequence; Bone Marrow Transplantation; Cytokines; DNA Primers; Gene Expression; Green | 2014 |
Alteration of mitochondrial function and ultrastructure in the hippocampus of pilocarpine-treated rat.
Topics: Animals; Hippocampus; Male; Mitochondria; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2014 |
Serotonin 1A receptor inhibits the status epilepticus induced by lithium-pilocarpine in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Analysis of Variance; Animals; Disease Mo | 2014 |
Reduced expression of Phospholipase C beta in hippocampal interneuron during pilocarpine induced status epilepticus in mice.
Topics: Animals; Disease Models, Animal; Down-Regulation; Female; Hippocampus; Immunohistochemistry; Interne | 2014 |
NK1 receptors antagonism of dorsal hippocampus counteract the anxiogenic-like effects induced by pilocarpine in non-convulsive Wistar rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Dipeptides; Dose-Response Relationship, Drug; Hippoc | 2014 |
Participation of bone marrow-derived cells in hippocampal vascularization after status epilepticus.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Epilepsy, Temporal Lobe; Hippocampus; Mice, Inbred | 2014 |
The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Frontal Lobe; Gene Expression Regulation; Mal | 2014 |
Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Astrocytes; Cell Line; Coculture Techni | 2014 |
Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Chronic Disease; Disease Models, A | 2014 |
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ani | 2014 |
Attention and executive functions in a rat model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Attention; Brain; Brain Mapping; Carbamates; Cell Count; Disease Models, A | 2014 |
Reduced hippocampal manganese-enhanced MRI (MEMRI) signal during pilocarpine-induced status epilepticus: edema or apoptosis?
Topics: Animals; Aquaporins; Caspase 3; Hippocampus; Magnetic Resonance Imaging; Male; Pilocarpine; Proto-On | 2014 |
NDEL1 was decreased in the CA3 region but increased in the hippocampal blood vessel network during the spontaneous seizure period after pilocarpine-induced status epilepticus.
Topics: Animals; CA3 Region, Hippocampal; Capillaries; Carrier Proteins; Dentate Gyrus; Disease Models, Anim | 2014 |
Pre-control characterization of hippocampal epileptic models.
Topics: Algorithms; Animals; Disease Models, Animal; Electrodes, Implanted; Hippocampus; Kindling, Neurologi | 2014 |
Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Electroencephal | 2014 |
Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Exploratory Behavior; Kainic Acid; Male; Maze Learning; Memory, Sho | 2014 |
Beneficial influence of physical exercise following status epilepticus in the immature brain of rats.
Topics: Age Factors; Animals; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Cell Proliferation; Exerc | 2014 |
Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus.
Topics: Animals; Dendritic Spines; Disease Models, Animal; Electroencephalography; Gene Expression Regulatio | 2015 |
Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chronic Diseas | 2014 |
Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice.
Topics: Animals; Calcium Channels; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Mice; Molec | 2015 |
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Dis | 2014 |
Dynamics of hippocampal acetylcholine release during lithium-pilocarpine-induced status epilepticus in rats.
Topics: Acetylcholine; Animals; Extracellular Fluid; Hippocampus; Lithium; Male; Pilocarpine; Rats; Rats, Sp | 2014 |
Temporally unstructured electrical stimulation to the amygdala suppresses behavioral chronic seizures of the pilocarpine animal model.
Topics: Amygdala; Animals; Deep Brain Stimulation; Disease Models, Animal; Male; Muscarinic Agonists; Piloca | 2014 |
Effects of ketogenic diets on the occurrence of pilocarpine-induced status epilepticus of rats.
Topics: Animals; Coconut Oil; Convulsants; Diet, Ketogenic; Dietary Fats; Energy Intake; Male; Neuroprotecti | 2015 |
Critical role of canonical transient receptor potential channel 7 in initiation of seizures.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Electric Stimulation; Electroencephalography; L | 2014 |
A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Disease Progression; Female; Male; M | 2014 |
Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy.
Topics: Adolescent; Adult; Animals; CA3 Region, Hippocampal; Case-Control Studies; Child; Dendrites; Epileps | 2015 |
Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Mice; Micr | 2015 |
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green | 2015 |
p75NTR, but not proNGF, is upregulated following status epilepticus in mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Excitatory Amino Acid Agonists; | 2014 |
Long-term decrease in Na+,K+-ATPase activity after pilocarpine-induced status epilepticus is associated with nitration of its alpha subunit.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Hippocampus; Isoenzymes; Male; Mice, Inbred | 2014 |
Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Down-Regulation; Hippocampus; Indomethac | 2014 |
Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate | 2014 |
Ameliorating effects of proglumide on neurobehavioral and biochemical deficits in animal model of status epilepticus.
Topics: Animals; Cognition; Disease Models, Animal; Glutathione; Lithium; Male; Motor Activity; Oxidative St | 2014 |
Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing.
Topics: Animals; Base Sequence; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Disease | 2014 |
Long-term increases in BK potassium channel underlie increased action potential firing in dentate granule neurons following pilocarpine-induced status epilepticus in rats.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Dentate Gyrus; Large-Conductance Calcium-Activ | 2015 |
Bumetanide is not capable of terminating status epilepticus but enhances phenobarbital efficacy in different rat models.
Topics: Animals; Anticonvulsants; Basolateral Nuclear Complex; Bumetanide; Disease Models, Animal; Drug Syne | 2015 |
Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diazepam; Disease Models, A | 2015 |
The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus.
Topics: Animals; Cognition Disorders; Lithium Compounds; Male; Oxidative Stress; Pentoxifylline; Pilocarpine | 2014 |
Optimization of pilocarpine-mediated seizure induction in immunodeficient NodScid mice.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal L | 2015 |
Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Cerebral Cortex; Electroencephalography; Encepha | 2015 |
Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrodes, Implanted; Electroencephalog | 2015 |
The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus.
Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Anticonvulsants; Cell Count; Chromatography, H | 2015 |
Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Disease Models, Animal; Encephalitis; Hippocamp | 2015 |
Status epilepticus results in region-specific alterations in seizure susceptibility along the hippocampal longitudinal axis.
Topics: Animals; Disease Models, Animal; Hippocampus; Lithium Compounds; Male; Microelectrodes; Pilocarpine; | 2015 |
Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1.
Topics: Animals; Dendritic Spines; Docosahexaenoic Acids; Epilepsy, Temporal Lobe; Hippocampus; Limbic Syste | 2015 |
Effect of Argemone mexicana (L.) against lithium-pilocarpine induced status epilepticus and oxidative stress in Wistar rats.
Topics: Animals; Argemone; Brain; Lipid Peroxidation; Lithium Compounds; Male; Oxidative Stress; Pilocarpine | 2015 |
Astrocytic Cx 43 and Cx 40 in the mouse hippocampus during and after pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; Connexin 43; Connexins; Disease Models, Animal; Electroencephalography; Gap Jun | 2015 |
EP2 Receptor Signaling Regulates Microglia Death.
Topics: Alprostadil; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Female; Gene Expression Re | 2015 |
Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Age Factors; Analysis of Variance; Animals; Anticonvulsants; Cognition Disorders; Diazepam; Disease | 2015 |
State and parameter estimation of a neural mass model from electrophysiological signals during the status epilepticus.
Topics: Algorithms; Animals; CA1 Region, Hippocampal; Convulsants; Dentate Gyrus; Electroencephalography; El | 2015 |
Pilocarpine-induced convulsive activity is limited by multidrug transporters at the rodent blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2015 |
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Ge | 2015 |
Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam.
Topics: Animals; Anticonvulsants; Brain Edema; Cell Death; Disease Models, Animal; Levetiracetam; Magnetic R | 2015 |
Dynamic Expression of MicroRNAs (183, 135a, 125b, 128, 30c and 27a) in the Rat Pilocarpine Model and Temporal Lobe Epilepsy Patients.
Topics: Adult; Aged; Animals; Child; Disease Models, Animal; Drug Resistant Epilepsy; Epilepsy, Temporal Lob | 2015 |
Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Menstrual C | 2015 |
Contrasting effects of Na+, K+-ATPase activation on seizure activity in acute versus chronic models.
Topics: Animals; Antibodies; Anticonvulsants; Brain Waves; Convulsants; Disease Models, Animal; Electroencep | 2015 |
Ischemic-hypoxic mechanisms leading to hippocampal dysfunction as a consequence of status epilepticus.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Hypoxia, Brai | 2015 |
Transcranial focal electrical stimulation reduces the convulsive expression and amino acid release in the hippocampus during pilocarpine-induced status epilepticus in rats.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Pilocarp | 2015 |
Perineuronal net degradation in epilepsy.
Topics: Animals; Hippocampus; Male; Mice; Nerve Net; Oligodendroglia; Pilocarpine; Rats; Rats, Sprague-Dawle | 2015 |
Analysis of electrocorticographic patterns in rats fed standard or hyperlipidic diets in a normal state or during status epilepticus.
Topics: Algorithms; Alpha Rhythm; Animals; Beta Rhythm; Brain Waves; Computational Biology; Cortical Excitab | 2016 |
Endothelial NOS activation induces the blood-brain barrier disruption via ER stress following status epilepticus.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Caveolin 1; Cerebral Cortex; Disease Models, Animal; Endo | 2015 |
Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Levetiracetam; Male; Mice | 2015 |
Increased CCL2, CCL3, CCL5, and IL-1β cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures.
Topics: Animals; Biomarkers; Chemokine CCL2; Chemokine CCL3; Chemokine CCL5; Disease Models, Animal; Hippoca | 2015 |
Role of the Mitochondrial Calcium Uniporter in Rat Hippocampal Neuronal Death After Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Calcium Channels; Cell Death; Hippocampus; Male; Mitochondria; Neurons; Pilocarpine; Rats; | 2015 |
Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy.
Topics: Animals; Antioxidants; Cell Death; Cognition Disorders; Disease Models, Animal; Epilepsy, Temporal L | 2015 |
Deep hypothermia for the treatment of refractory status epilepticus.
Topics: Animals; Convulsants; Drug Resistant Epilepsy; Electroencephalography; Hypothermia, Induced; Lithium | 2015 |
Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats.
Topics: Animals; Disease Models, Animal; Fenclonine; Gliosis; Hippocampus; Lithium; Magnetic Resonance Imagi | 2016 |
Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and kainic acid.
Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; | 2015 |
Bimodal Imaging of Inflammation with SPECT/CT and MRI Using Iodine-125 Labeled VCAM-1 Targeting Microparticle Conjugates.
Topics: Animals; Antibodies, Monoclonal; Brain; Contrast Media; Ferric Compounds; Image Processing, Computer | 2015 |
Lacosamide modulates interictal spiking and high-frequency oscillations in a model of mesial temporal lobe epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Disease Models, Animal; Electrocorticography; Electrodes, Impl | 2015 |
Hypothermia mitigates neurochemical alterations in rat's cerebral cortex during status epilepticus induced by pilocarpine.
Topics: Amino Acids; Animals; Cerebral Cortex; Hyperthermia, Induced; Male; Muscarinic Agonists; Neurotransm | 2015 |
Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cells, Cultured; Diazepam; Disease Models, Animal; Enzym | 2015 |
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats.
Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; D | 2015 |
Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Cell Death; Di | 2015 |
[Changes in CD40 expression in the pallium and hippocampus in epileptic rats].
Topics: Animals; CD40 Antigens; Epilepsy; Hippocampus; Immunohistochemistry; Lithium; Microglia; Pilocarpine | 2015 |
High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process?
Topics: Animals; Behavior, Animal; Biomarkers; C-Reactive Protein; Convulsants; Cytokines; Epilepsy; Fatty A | 2015 |
Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats.
Topics: Animals; Apoptosis Inducing Factor; Astrocytes; Calnexin; Disease Models, Animal; Endoplasmic Reticu | 2015 |
Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cytokines; Deep Brain Stimulation; Disease Mode | 2015 |
Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain.
Topics: Animals; Brain; Choline; Convulsants; Disease Models, Animal; Electrochemistry; Electron Transport C | 2015 |
Newly generated neurons at 2 months post-status epilepticus are functionally integrated into neuronal circuitry in mouse hippocampus.
Topics: Animals; Cell Differentiation; Cell Movement; Cholera Toxin; Disease Models, Animal; Female; Follow- | 2015 |
Suppressing cAMP response element-binding protein transcription shortens the duration of status epilepticus and decreases the number of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Brain Chemistry; Convulsants; CREB-Binding Protein; Disease Models, Animal; Female; Immunob | 2015 |
Protein-caloric dietary restriction inhibits mossy fiber sprouting in the pilocarpine model of TLE without significantly altering seizure phenotype.
Topics: Animals; Caloric Restriction; Diet, Protein-Restricted; Disease Models, Animal; Electroencephalograp | 2015 |
Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Electroencephalography; Male; Mice; Piloca | 2015 |
Time-course changes of hippocalcin expression in the mouse hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Gene Expression Regulation; Hippocalcin; Hippocampus; Male; Mice; Mice, Inbred ICR; Nerve D | 2016 |
Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus.
Topics: Animals; Anticonvulsants; Apoptosis; Benzodiazepines; Convulsants; Exploratory Behavior; GABA Agonis | 2015 |
Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium-pilocarpine model of temporal lobe epilepsy in rats.
Topics: Animals; Biomarkers; Brain; Electroencephalography; Epilepsy, Temporal Lobe; Female; Lithium; Male; | 2015 |
Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus.
Topics: Action Potentials; Analysis of Variance; Animals; CA1 Region, Hippocampal; Dendrites; Disease Models | 2015 |
Network pharmacology for antiepileptogenesis: Tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid A | 2015 |
The progressive changes of filamentous actin cytoskeleton in the hippocampal neurons after pilocarpine-induced status epilepticus.
Topics: Actin Cytoskeleton; Actins; Analysis of Variance; Animals; Calcium-Binding Proteins; Cells, Cultured | 2015 |
Extracellular levels of ATP and acetylcholine during lithium-pilocarpine induced status epilepticus in rats.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anticonvulsants; Diazepam; Extracellular Space; Hipp | 2016 |
Axonal plasticity of age-defined dentate granule cells in a rat model of mesial temporal lobe epilepsy.
Topics: Animals; Animals, Newborn; Axons; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Mossy Fiber | 2016 |
A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice.
Topics: Adenylyl Cyclases; Animals; Cell Death; Convulsants; Disease Models, Animal; Hippocampus; Kainic Aci | 2016 |
The pervasive reduction of GABA-mediated synaptic inhibition of principal neurons in the hippocampus during status epilepticus.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Poten | 2016 |
Structural alterations in the rat brain and behavioral impairment after status epilepticus: An MRI study.
Topics: Animals; Brain; Disease Models, Animal; Lithium Compounds; Magnetic Resonance Imaging; Male; Motor A | 2016 |
Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups.
Topics: Animals; Animals, Newborn; Brain; Caspase 3; Disease Models, Animal; Electrocorticography; Electroen | 2016 |
Pilocarpine-induced epilepsy alters the expression and daily variation of the nuclear receptor RORα in the hippocampus of rats.
Topics: Animals; Chronic Disease; Circadian Rhythm; Epilepsy; Gene Expression Regulation; Hippocampus; Male; | 2016 |
Transcranial focal electrical stimulation reduces seizure activity and hippocampal glutamate release during status epilepticus.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Pilocarpine; Rats; Status Epilepticus; | 2015 |
Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy.
Topics: Action Potentials; Animals; Dentate Gyrus; Inhibitory Postsynaptic Potentials; Interneurons; Male; P | 2016 |
CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy.
Topics: Active Transport, Cell Nucleus; Animals; Convulsants; Cyclic AMP Response Element-Binding Protein; D | 2016 |
Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons.
Topics: Animals; Exoribonucleases; GABAergic Neurons; Gene Expression Regulation; Hippocampus; Interneurons; | 2016 |
Status Epilepticus Enhances Depotentiation after Fully Established LTP in an NMDAR-Dependent but GluN2B-Independent Manner.
Topics: Animals; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiati | 2016 |
Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats.
Topics: Age Factors; Animals; Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Male; Perio | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade.
Topics: Animals; Anticonvulsants; Apoptosis; Argonaute Proteins; Carbazoles; Convulsants; Disease Models, An | 2016 |
Physical training decreases susceptibility to pilocarpine-induced seizures in the injured rat brain.
Topics: Animals; Brain; Brain Injuries, Traumatic; Calbindin 2; Glial Fibrillary Acidic Protein; Male; Neuro | 2016 |
Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain.
Topics: Animals; Carrier Proteins; Cation Transport Proteins; Cell Movement; Disease Models, Animal; Gene Ex | 2016 |
The inhibition of transforming growth factor beta-activated kinase 1 contributed to neuroprotection via inflammatory reaction in pilocarpine-induced rats with epilepsy.
Topics: Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Encephalitis; Hippocampus; Interleu | 2016 |
Status epilepticus triggers early mitochondrial fusion in the rat hippocampus in a lithium-pilocarpine model.
Topics: Animals; Blotting, Western; Dynamins; GTP Phosphohydrolases; Hippocampus; Injections, Intraperitonea | 2016 |
Changes of AMPA receptor properties in the neocortex and hippocampus following pilocarpine-induced status epilepticus in rats.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hippocampus; Neocortex; Pilocar | 2016 |
Dual mechanisms of rapid expression of anxiety-related behavior in pilocarpine-treated epileptic mice.
Topics: Actins; Analysis of Variance; Animals; Anxiety; Behavior Observation Techniques; Brain-Derived Neuro | 2016 |
Spatiotemporal profile of Map2 and microglial changes in the hippocampal CA1 region following pilocarpine-induced status epilepticus.
Topics: Animals; CA1 Region, Hippocampal; Immunohistochemistry; Male; Microglia; Microtubule-Associated Prot | 2016 |
Hippocampal distribution of IL-1β and IL-1RI following lithium-pilocarpine-induced status epilepticus in the developing rat.
Topics: Animals; Convulsants; Disease Models, Animal; Hippocampus; Interleukin-1beta; Lithium; Pilocarpine; | 2016 |
Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus.
Topics: Animals; Astrocytes; Axl Receptor Tyrosine Kinase; CD40 Antigens; Disease Models, Animal; Hippocampu | 2016 |
Rats with Malformations of Cortical Development Exhibit Decreased Length of AIS and Hypersensitivity to Pilocarpine-Induced Status Epilepticus.
Topics: Animals; Axon Initial Segment; Disease Models, Animal; Female; Hypersensitivity; Malformations of Co | 2016 |
Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Convulsants; Disease Models, Animal; Fluoresceins; Ge | 2016 |
Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain.
Topics: Animals; Carrier Proteins; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Gree | 2016 |
Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus.
Topics: Adamantane; Adenosine Triphosphate; Aminoquinolines; Animals; Disease Models, Animal; Excitatory Ami | 2017 |
Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia.
Topics: Animals; Disease Models, Animal; Hippocampus; Ischemic Preconditioning; Male; Memory Disorders; Neur | 2016 |
Hippocampal YKL-40 expression in rats after status epilepticus.
Topics: Animals; Antigens, Nuclear; Chitinase-3-Like Protein 1; Cytoplasm; Disease Models, Animal; Fluoresce | 2016 |
Altered expression of neuronal CCR6 during pilocarpine induced status epilepticus in mice.
Topics: Animals; Calbindin 2; Calbindins; Dendrites; Disease Models, Animal; Female; GABAergic Neurons; Gene | 2016 |
Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amines; Animals; Behavior, Animal; Carbamazepine; Cognition; C | 2016 |
Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus.
Topics: Animals; Hippocampus; Male; Nerve Degeneration; Neurons; Phlorhizin; Pilocarpine; Rats; Rats, Wistar | 2016 |
Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Fluorometry; Glycyrrhizic A | 2016 |
Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Hippocam | 2016 |
The effect of some immunomodulatory and anti-inflammatory drugs on Li-pilocarpine-induced epileptic disorders in Wistar rats.
Topics: Animals; Anti-Inflammatory Agents; Dinoprostone; Electroencephalography; Encephalitis; HSP72 Heat-Sh | 2016 |
Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits.
Topics: Animals; Anticonvulsants; Brain; Cholinergic Agents; Disease Models, Animal; Drug Synergism; Drug Th | 2016 |
The cannabinoid receptor agonist WIN55.212 reduces consequences of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Agonists; Dentate Gyrus; Disease Models | 2016 |
Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats.
Topics: Animals; Anticonvulsants; Catalase; Diet; Disease Models, Animal; Hippocampus; Lipid Peroxidation; M | 2018 |
Leptomycin B ameliorates vasogenic edema formation induced by status epilepticus via inhibiting p38 MAPK/VEGF pathway.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Enzyme Inhibitors; Fatty Acids, U | 2016 |
Anticonvulsant effect of Rhynchophylline involved in the inhibition of persistent sodium current and NMDA receptor current in the pilocarpine rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippoc | 2016 |
Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Profiling; Gene Expression | 2016 |
Increased precursor microRNA-21 following status epilepticus can compete with mature microRNA-21 to alter translation.
Topics: Animals; Binding Sites; Computational Biology; Disease Models, Animal; Humans; Mice; MicroRNAs; Musc | 2016 |
Postictal alterations induced by intrahippocampal injection of pilocarpine in C57BL/6 mice.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Male; Me | 2016 |
Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents.
Topics: Animals; Benzyl Alcohols; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Tempor | 2017 |
[Effect of a microRNA-132 antagonist on pilocarpine-induced status epilepticus in young rats].
Topics: Animals; Electroencephalography; Male; MicroRNAs; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Ep | 2016 |
Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Cerebral Cortex; Cytokines; Electroencephalography | 2016 |
Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats.
Topics: Animals; Disease Models, Animal; Female; Motor Activity; Physical Conditioning, Animal; Pilocarpine; | 2016 |
Memantine attenuates cognitive impairments after status epilepticus induced in a lithium-pilocarpine model.
Topics: Animals; Cognition; Cognitive Dysfunction; Exploratory Behavior; Extinction, Psychological; Lithium; | 2016 |
Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis.
Topics: Aldehydes; Animals; Antioxidants; Cognitive Dysfunction; Disease Models, Animal; Epilepsy, Temporal | 2017 |
TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroence | 2017 |
Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Depression; Disease Models, Animal; Drug Delive | 2017 |
Effects of protease-activated receptor 1 inhibition on anxiety and fear following status epilepticus.
Topics: Animals; Anxiety; Epilepsy, Temporal Lobe; Fear; Male; Pilocarpine; Pyrroles; Quinazolines; Rats; Ra | 2017 |
c-jun is differentially expressed in embryonic and adult neural precursor cells.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Embryonic Stem Cells; Female; Immunohistochemis | 2017 |
Stimulation of the medial septum improves performance in spatial learning following pilocarpine-induced status epilepticus.
Topics: Animals; Cognition; Deep Brain Stimulation; Disease Models, Animal; Electrocorticography; Explorator | 2017 |
Pilocarpine-Induced Status Epilepticus Is Associated with Changes in the Actin-Modulating Protein Synaptopodin and Alterations in Long-Term Potentiation in the Mouse Hippocampus.
Topics: Actins; Animals; Cytoskeletal Proteins; Hippocampus; Long-Term Potentiation; Male; Mice; Mice, Inbre | 2017 |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats.
Topics: Action Potentials; Animals; Anticonvulsants; Cell Count; Diazepam; Disease Models, Animal; Electric | 2017 |
VEGF regulates hippocampal neurogenesis and reverses cognitive deficits in immature rats after status epilepticus through the VEGF R2 signaling pathway.
Topics: Animals; Cell Proliferation; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Neuroge | 2017 |
The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Flow Cytometry; Gene Expression Regulation; Interleukin-4; Leukocyt | 2017 |
Treatment of experimental status epilepticus with synergistic drug combinations.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; | 2017 |
Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?
Topics: Animals; Anticonvulsants; Cerebral Cortex; Convulsants; Disease Models, Animal; Lithium Chloride; Ma | 2017 |
Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis.
Topics: Animals; Cerebral Cortex; Cytokines; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; I | 2018 |
Status epilepticus induces a TrkB to p75 neurotrophin receptor switch and increases brain-derived neurotrophic factor interaction with p75 neurotrophin receptor: an initial event in neuronal injury induction.
Topics: Animals; Benzoxazines; Blotting, Western; Brain-Derived Neurotrophic Factor; Coloring Agents; Electr | 2008 |
Ischemia and status epilepitcus result in enhanced phosphorylation of calcium and calmodulin-stimulated protein kinase II on threonine 253.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Ischem | 2008 |
Characterization of osteopontin expression and function after status epilepticus.
Topics: Animals; CD11b Antigen; Cell Degranulation; Cells, Cultured; Disease Models, Animal; Electroshock; E | 2008 |
Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE).
Topics: Animals; Chloride Channels; Chlorides; Disease Models, Animal; Epilepsy; Gene Expression Regulation; | 2008 |
Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine.
Topics: Animals; Behavior, Animal; Depression; Epilepsy, Temporal Lobe; Fluoxetine; Hippocampus; Lithium Chl | 2008 |
Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Caspases; Electroencephalography; Enzyme Activation; Enzyme Inhibitors; Et | 2008 |
Differential changes in mGlu2 and mGlu3 gene expression following pilocarpine-induced status epilepticus: a comparative real-time PCR analysis.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Gene Expression Regulation; Pilocarpine; Rats | 2008 |
Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain Injuries; Diazepam; Disease Models, A | 2008 |
The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats.
Topics: Animals; Antimanic Agents; Cell Death; Convulsants; Disease Models, Animal; Electroencephalography; | 2008 |
Region-specific alterations in astroglial TWIK-related acid-sensitive K+-1 channel immunoreactivity in the rat hippocampal complex following pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Hippocampus; Male; Nerve Tissue Proteins; Pilo | 2008 |
Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Antipyrine; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone | 2009 |
Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats.
Topics: Analysis of Variance; Animals; Dentate Gyrus; Disease Models, Animal; Down-Regulation; Epilepsy, Tem | 2008 |
Minimal latency to hippocampal epileptogenesis and clinical epilepsy after perforant pathway stimulation-induced status epilepticus in awake rats.
Topics: Action Potentials; Animals; Behavior, Animal; Electric Stimulation; Hippocampus; Humans; Male; Musca | 2008 |
Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Hippocampus; Humans; Levetiracetam; Male | 2008 |
Status epilepticus produces chronic alterations in cardiac sympathovagal balance.
Topics: Analysis of Variance; Animals; Atropine; Baroreflex; Blood Pressure; Disease Models, Animal; Heart R | 2009 |
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Diazepam; Disease | 2008 |
mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.
Topics: Animals; Disease Progression; Female; Gene Deletion; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mi | 2008 |
Extracellular matrix protein SC1/hevin in the hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Calcium-Binding Proteins; Disease Models, Animal; Extracellular Matrix Proteins; Fluorescei | 2008 |
Oral administration of fructose-1,6-diphosphate has anticonvulsant activity.
Topics: 4-Butyrolactone; Action Potentials; Administration, Oral; Animals; Anticonvulsants; Brain; Cerebral | 2008 |
Serotonin depletion effects on the pilocarpine model of epilepsy.
Topics: 5,7-Dihydroxytryptamine; Acute Disease; Animals; Behavior, Animal; Chronic Disease; Disease Models, | 2008 |
Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Cell Death; Cell Proliferation; Convulsants; Disease Models | 2008 |
Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus.
Topics: 4-Aminopyridine; Animals; Calcium; Disease Models, Animal; Extracellular Fluid; Female; Gene Express | 2008 |
Myocyte-specific enhancer binding factor 2C (MEF2C) expression in the dentate gyrus during development and after pilocarpine-induced status epilepticus: a preliminary report.
Topics: Animals; Dentate Gyrus; In Situ Hybridization; Male; MEF2 Transcription Factors; Myogenic Regulatory | 2008 |
Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats.
Topics: Animals; Blotting, Western; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models | 2008 |
Antagonism of peripheral inflammation reduces the severity of status epilepticus.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Brain; Enz | 2009 |
Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.
Topics: Analysis of Variance; Animals; Antigens, Surface; Brain; Cocaine; Dendrites; Disease Models, Animal; | 2008 |
Region-specific plasticity in the epileptic rat brain: a hippocampal and extrahippocampal analysis.
Topics: Amygdala; Animals; Astrocytes; Cell Differentiation; Cell Division; Cell Survival; Chemokine CXCL12; | 2009 |
Complex time-dependent alterations in the brain expression of different drug efflux transporter genes after status epilepticus.
Topics: Analysis of Variance; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cyclo | 2009 |
Participation of mu-calpain in status epilepticus-induced hippocampal injury.
Topics: Animals; Antipsychotic Agents; Apoptosis; Apoptosis Inducing Factor; BH3 Interacting Domain Death Ag | 2009 |
Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat.
Topics: Analysis of Variance; Animals; Conditioning, Classical; Disease Models, Animal; Electroshock; Emotio | 2009 |
Neurogenesis induced by seizures in the dentate gyrus is not related to mossy fiber sprouting but is age dependent in developing rats.
Topics: Animals; Cell Proliferation; Dentate Gyrus; Immunohistochemistry; Mossy Fibers, Hippocampal; Neuroge | 2008 |
Neurosteroids and epileptogenesis in the pilocarpine model: evidence for a relationship between P450scc induction and length of the latent period.
Topics: Animals; Cholesterol Side-Chain Cleavage Enzyme; Disease Models, Animal; Enzyme Induction; Male; Neu | 2009 |
Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Corpus Striatum; Disease Models, Animal; D | 2009 |
A simple quantitative method for analyzing electrographic status epilepticus in rats.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; | 2009 |
Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus.
Topics: Animals; Antineoplastic Agents; Astrocytes; Cell Death; Cell Shape; Convulsants; Dentate Gyrus; Dise | 2009 |
Autophagy is upregulated in rats with status epilepticus and partly inhibited by Vitamin E.
Topics: Animals; Antioxidants; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Male; Membrane Proteins; | 2009 |
The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death.
Topics: Animals; Atropine; Brain-Derived Neurotrophic Factor; Cells, Cultured; Corpus Striatum; Cyclic AMP R | 2009 |
Glutamine induces epileptiform discharges in superficial layers of the medial entorhinal cortex from pilocarpine-treated chronic epileptic rats in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminoisobutyric Acids; Animals; Bicuculline; Disease Models, A | 2009 |
[Number changes and axonal sprouting of neuropeptide Y interneurons in the hippocampus of pilocarpine-induced rats].
Topics: Animals; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Male; Neuropeptide Y; Pilocarpine; Rand | 2009 |
Vitamin E inhibits activated chaperone-mediated autophagy in rats with status epilepticus.
Topics: Animals; Antioxidants; Autophagy; Hippocampus; Lysosomal-Associated Membrane Protein 2; Male; Molecu | 2009 |
Morpho-physiologic characteristics of dorsal subicular network in mice after pilocarpine-induced status epilepticus.
Topics: Animals; Behavior, Animal; Calbindin 2; Calbindins; Data Interpretation, Statistical; Dendrites; Den | 2010 |
Long-term increasing co-localization of SCN8A and ankyrin-G in rat hippocampal cornu ammonis 1 after pilocarpine induced status epilepticus.
Topics: Animals; Ankyrins; Hippocampus; Kindling, Neurologic; Muscarinic Agonists; NAV1.1 Voltage-Gated Sodi | 2009 |
Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis.
Topics: Aging; Animals; Astrocytes; Blood-Brain Barrier; Encephalitis; Fluorescein-5-isothiocyanate; Genes, | 2009 |
The effects of pilocarpine-induced status epilepticus on oxidative stress/damage in developing animals.
Topics: Animals; Brain; Catalase; Cell Death; Chickens; DNA Damage; DNA, Single-Stranded; Malondialdehyde; M | 2010 |
Enhanced pyridoxal 5'-phosphate synthetic enzyme immunoreactivities do not contribute to GABAergic inhibition in the rat hippocampus following pilocarpine-induced status epilepticus.
Topics: Action Potentials; Animals; Cell Death; Dentate Gyrus; gamma-Aminobutyric Acid; Glial Fibrillary Aci | 2009 |
Motor map expansion in the pilocarpine model of temporal lobe epilepsy is dependent on seizure severity and rat strain.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Progression; Dose-Response Re | 2009 |
Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus.
Topics: Animals; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Hippocampus; Immunohistochemistry | 2009 |
Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Carbamazepine; Dentate Gyrus; Diazepam; Drug Administration Schedule; Glia | 2009 |
Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Biophysics; Blood Glucose; Brain Injuries; Co | 2009 |
EEG stages predict treatment response in experimental status epilepticus.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Disease Progressio | 2009 |
Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus.
Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Cell Count; Cell Death; Hippocampus; | 2009 |
ERK1/2 activation in reactive astrocytes of mice with pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; Cell Count; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Immunohistoc | 2009 |
Age-dependent mortality in the pilocarpine model of status epilepticus.
Topics: Age Factors; Animals; Convulsants; Electroencephalography; Male; Pilocarpine; Rats; Rats, Sprague-Da | 2009 |
Differential expression of activating transcription factor-2 and c-Jun in the immature and adult rat hippocampus following lithium-pilocarpine induced status epilepticus.
Topics: Activating Transcription Factor 2; Animals; Antimanic Agents; Blotting, Western; Hippocampus; Immuno | 2009 |
A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Estrous Cycle; Female; Pentobarbital; Pi | 2009 |
Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus.
Topics: Action Potentials; Animals; Extracellular Space; GABA Plasma Membrane Transport Proteins; GABA Uptak | 2009 |
CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE) .
Topics: Animals; Blood Vessels; Blood-Brain Barrier; Chemokine CCL2; Chemokine CCL3; Convulsants; Down-Regul | 2009 |
Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western | 2009 |
Erythropoietin pre-treatment prevents cognitive impairments following status epilepticus in rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Assoc | 2009 |
Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Gene Expression Regulation; Hypoxia; Mal | 2009 |
Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Animals; Anxiety Disorders; Brain; Cognition Disorders; Convulsants; Disease Models, Animal; Epileps | 2009 |
Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus.
Topics: Animals; Cerebral Cortex; Chronic Disease; Convulsants; Cyclic AMP-Dependent Protein Kinases; Diseas | 2009 |
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
Does pilocarpine-induced epilepsy in adult rats require status epilepticus?
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Inflammatio | 2009 |
Neuroprotection after status epilepticus by targeting protein interactions with postsynaptic density protein 95.
Topics: Animals; Cell Count; Cell Death; Disks Large Homolog 4 Protein; Hippocampus; Immunohistochemistry; I | 2009 |
Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Atropine Derivatives; Axons; Dentate Gyrus; Disease Models, Animal; Epilep | 2009 |
Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice.
Topics: Analysis of Variance; Animals; Convulsants; Guanidines; Male; Mice; Nitric Oxide Synthase Type II; P | 2009 |
Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Choroid Plexus; Chronic Dis | 2010 |
Inhibitory effect of methyl ethyl ketone upon the enhancement of cerebral blood flow during status epilepticus induced by lithium-pilocarpine.
Topics: Animals; Anticonvulsants; Autoradiography; Butanones; Carbon Radioisotopes; Cerebellum; Cerebrovascu | 2009 |
Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage.
Topics: Animals; Behavior, Animal; Cognition; Female; Hippocampus; Learning; Mice; Neuroglia; Neurons; Piloc | 2009 |
Seizures increase cell proliferation in the dentate gyrus by shortening progenitor cell-cycle length.
Topics: Animals; Animals, Newborn; Cell Cycle; Cell Proliferation; Dentate Gyrus; Hippocampus; Humans; Immun | 2009 |
Development of epileptiform excitability in the deep entorhinal cortex after status epilepticus.
Topics: Animals; Blotting, Western; Cell Count; Electroencephalography; Electrophysiology; Entorhinal Cortex | 2009 |
Brain-derived neurotrophic factor facilitates TrkB down-regulation and neuronal injury after status epilepticus in the rat hippocampus.
Topics: Animals; Antibodies; Brain-Derived Neurotrophic Factor; Cell Death; Disease Models, Animal; Down-Reg | 2009 |
Methyl ethyl ketone blocks status epilepticus induced by lithium-pilocarpine in rats.
Topics: Acetone; Animals; Anticonvulsants; Butanones; Diet, Ketogenic; Hippocampus; Lithium Chloride; Male; | 2009 |
Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat.
Topics: Aging; Animals; Brain Injuries; Cell Count; Cell Death; Hippocampus; Immunohistochemistry; Male; Neu | 2009 |
Nestin down-regulation of cortical radial glia is delayed in rats submitted to recurrent status epilepticus during early postnatal life.
Topics: Animals; Animals, Newborn; Biomarkers; Cerebral Cortex; Disease Models, Animal; Immunohistochemistry | 2009 |
The extracellular matrix protein SC1/Hevin localizes to multivesicular bodies in Bergmann glial fibers in the adult rat cerebellum.
Topics: Animals; Calcium-Binding Proteins; Cerebellum; Extracellular Matrix Proteins; Glial Fibrillary Acidi | 2010 |
Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model.
Topics: Animals; Antioxidants; Cell Count; Cytoprotection; Female; Hippocampus; Nerve Degeneration; Neurons; | 2009 |
Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone.
Topics: Animals; Anticonvulsants; Buspirone; Catalase; Hippocampus; Lipid Peroxidation; Male; Nitrites; Oxid | 2010 |
Nuclear localization of Ca(v)2.2 and its distribution in the mouse central nervous system, and changes in the hippocampus during and after pilocarpine-induced status epilepticus.
Topics: Animals; Calcium Channels, N-Type; Cell Nucleus; Convulsants; Hippocampus; Immunohistochemistry; Mic | 2010 |
Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats.
Topics: Aconitine; Actin Cytoskeleton; Action Potentials; Animals; Arrhythmias, Cardiac; Biomarkers; Blood P | 2009 |
Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stim | 2010 |
Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Comorbidity; Convulsants; Depressive Disorder; Dis | 2010 |
Status epilepticus affects the gigantocellular network of the pontine reticular formation.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cell Shape; Electrodes, Implanted; Electroencephalograp | 2009 |
Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Hippocampus; Humans; Im | 2009 |
Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy.
Topics: Animals; Antigens; Blood-Brain Barrier; Capillaries; Cell Proliferation; Convulsants; Disease Models | 2010 |
Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats.
Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Convulsants; Drug Interaction | 2010 |
Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex.
Topics: Animals; Biomarkers; Cell Count; Cerebral Cortex; Convulsants; Disease Models, Animal; Electric Stim | 2010 |
Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; F | 2010 |
Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Convulsants; Dendritic Spines; Dentate Gyrus; Disease Models, Animal; Epilepsy, | 2010 |
Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; CA1 Region, Hippocampal; Cell Count; Chemokine CCL2; Dentate Gyrus; Endothelial | 2009 |
Quantitative MRI predicts status epilepticus-induced hippocampal injury in the lithium-pilocarpine rat model.
Topics: Analysis of Variance; Animals; Brain Mapping; Cell Count; Cell Death; Cerebrovascular Circulation; H | 2010 |
Akt pathway activation and increased neuropeptide Y mRNA expression in the rat hippocampus: implications for seizure blockade.
Topics: Analysis of Variance; Animals; Blotting, Western; Hippocampus; Immunohistochemistry; Male; Neuropept | 2010 |
Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy.
Topics: Analysis of Variance; Animals; Antigens, CD; Bone Marrow Transplantation; Cell Movement; Disease Mod | 2010 |
Oxidative stress mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Blotting, Western; Caspase 3; Cell Death; Hippocampus; Immunohistochemistry; Immunosuppress | 2010 |
Mitochondrial base excision repair pathway failed to respond to status epilepticus induced by pilocarpine.
Topics: Animals; DNA Damage; DNA Glycosylases; DNA Polymerase gamma; DNA Repair; DNA-(Apurinic or Apyrimidin | 2010 |
Diffusion tensor MRI of axonal plasticity in the rat hippocampus.
Topics: Animals; Convulsants; Diffusion Magnetic Resonance Imaging; Hippocampus; Kainic Acid; Male; Neuronal | 2010 |
Time-dependent changes in learning ability and induction of long-term potentiation in the lithium-pilocarpine-induced epileptic mouse model.
Topics: Animals; Biophysics; Conditioning, Classical; Disease Models, Animal; Electric Stimulation; Excitato | 2010 |
Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus.
Topics: Animals; Anterior Thalamic Nuclei; Bicuculline; Convulsants; Electroencephalography; GABA Agents; Hu | 2010 |
Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain; Bromodeoxyuridine; Cell Count; Cell | 2010 |
Granulocyte colony-stimulating factor treatment prevents cognitive impairment following status epilepticus in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cognition Disorders; Granulocyte Colony-S | 2010 |
Effect of ketogenic diet on nucleotide hydrolysis and hepatic enzymes in blood serum of rats in a lithium-pilocarpine-induced status epilepticus.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alkaline Phosphatase; Animals; Aspartate Aminotransfe | 2010 |
Decreased GABA receptor in the striatum and spatial recognition memory deficit in epileptic rats: effect of Bacopa monnieri and bacoside-A.
Topics: Animals; Anticonvulsants; Bacopa; Basal Ganglia; Behavior, Animal; Bicuculline; Binding, Competitive | 2010 |
Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Arachidonic Acids; Blotting, Western; Cannabinoids; Dentate Gyrus; Disea | 2010 |
Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats.
Topics: Age Factors; Alkanes; Analysis of Variance; Animals; Disease Models, Animal; Drug Interactions; Gene | 2010 |
Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bumetanide; Cell Count; | 2010 |
Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2010 |
Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Dantrolene; Dizocilpine Maleate; Epilepsy; Excitatory | 2010 |
Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus.
Topics: Animals; Cerebrovascular Circulation; Convulsants; Disease Models, Animal; Epilepsy; Hippocampus; Ma | 2010 |
Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2.
Topics: Animals; Cell Membrane; HEK293 Cells; Hippocampus; Humans; K Cl- Cotransporters; Mice; Mice, Knockou | 2010 |
Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans.
Topics: Animals; Convulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; H | 2010 |
Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms.
Topics: Animals; Convulsants; Depressive Disorder; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocam | 2010 |
Status epilepticus alters hippocampal PKAbeta and PKAgamma expression in mice.
Topics: Animals; Convulsants; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Electroencephalography | 2010 |
Ketogenic diet exhibits neuroprotective effects in hippocampus but fails to prevent epileptogenesis in the lithium-pilocarpine model of mesial temporal lobe epilepsy in adult rats.
Topics: Animals; Anticonvulsants; Caloric Restriction; Cerebral Cortex; Diet, Ketogenic; Dietary Carbohydrat | 2010 |
Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dialysis; Excitatory Amino Acids; gamma-Aminobutyric Acid; | 2011 |
GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Carbamates; Cell Line; Dipeptides; Disease Models, | 2010 |
Time course of neuronal damage in the hippocampus following lithium-pilocarpine status epilepticus in 12-day-old rats.
Topics: Animals; Animals, Newborn; Dentate Gyrus; Disease Models, Animal; Hippocampus; Lithium Chloride; Mal | 2010 |
The protective effects of interleukin-18 and interferon-γ on neuronal damages in the rat hippocampus following status epilepticus.
Topics: Animals; Astrocytes; Disease Models, Animal; Hippocampus; Infusions, Intraventricular; Interferon ga | 2010 |
Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system.
Topics: Animals; CA3 Region, Hippocampal; Disease Models, Animal; Dose-Response Relationship, Drug; Electroe | 2010 |
Basal dendrites are present in newly born dentate granule cells of young but not aged pilocarpine-treated chronic epileptic rats.
Topics: Age Factors; Animals; Chronic Disease; Dendrites; Dentate Gyrus; Disease Models, Animal; Male; Maze | 2010 |
Elevated cerebral blood flow and vascular density in the amygdala after status epilepticus in rats.
Topics: Amygdala; Animals; Cerebrovascular Circulation; Hemodynamics; Immunohistochemistry; Magnetic Resonan | 2010 |
Vascular endothelial growth factor attenuates status epilepticus-induced behavioral impairments in rats.
Topics: Adaptation, Ocular; Analysis of Variance; Animals; Behavioral Symptoms; Disease Models, Animal; Hipp | 2010 |
Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats.
Topics: Animals; Disease Models, Animal; Electric Stimulation Therapy; Hippocampus; Lithium Chloride; Male; | 2011 |
P2X7 receptor differentially modulates astroglial apoptosis and clasmatodendrosis in the rat brain following status epilepticus.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Astrocytes; CA1 Region, Hippocampal; Cell Shape; Dendrit | 2011 |
Mild hypothermia pretreatment protects against pilocarpine-induced status epilepticus and neuronalapoptosis in immature rats.
Topics: Animals; Apoptosis; Convulsants; Hypothermia, Induced; In Situ Nick-End Labeling; Neurons; Pilocarpi | 2011 |
High ratio of synaptic excitation to synaptic inhibition in hilar ectopic granule cells of pilocarpine-treated rats.
Topics: Animals; Cell Movement; Convulsants; Dentate Gyrus; Electric Stimulation; Excitatory Postsynaptic Po | 2010 |
Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; Calcium-Binding Proteins; Cell Count; Cerebral Cortex | 2010 |
Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy.
Topics: Alternative Splicing; Animals; Calcium; Dentate Gyrus; Epilepsy, Temporal Lobe; Exons; Large-Conduct | 2011 |
P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Count; Chemokine CCL2; Chemok | 2010 |
Induction of heat shock proteins in the adult rat cerebral cortex following pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; Cerebral Cortex; Heme Oxygenase (Decyclizing); HSP27 Heat-Shock Proteins; HSP70 | 2011 |
Early life LiCl-pilocarpine-induced status epilepticus reduces acutely hippocampal glutamate uptake and Na+/K+ ATPase activity.
Topics: Animals; Convulsants; Enzyme Activation; Glutamic Acid; Hippocampus; Lithium Chloride; Male; Nerve D | 2011 |
An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus.
Topics: Animals; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channels, T-Type; Male; Models, | 2011 |
Expression and localization of annexin A7 in the rat lithium-pilocarpine model of acquired epilepsy.
Topics: Animals; Annexin A7; Calcium; Cerebral Cortex; Disease Models, Animal; Fluorescent Antibody Techniqu | 2010 |
Altered physiology and pharmacology in the corticostriatal system in a model of temporal lobe epilepsy.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitato | 2011 |
Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Convulsants; Gene Expression Profiling; Hippocampus; Lithium; Male; MicroRNAs; Oligonucleot | 2011 |
Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus.
Topics: Analysis of Variance; Animals; Body Temperature; Cytokines; Fever; Hippocampus; Hydroxymethylglutary | 2011 |
Selective loss and axonal sprouting of GABAergic interneurons in the sclerotic hippocampus induced by LiCl-pilocarpine.
Topics: Animals; Axons; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lithium | 2011 |
Comparative neuroanatomical and temporal characterization of FluoroJade-positive neurodegeneration after status epilepticus induced by systemic and intrahippocampal pilocarpine in Wistar rats.
Topics: Animals; Fluoresceins; Fluorescent Dyes; Hippocampus; Male; Microinjections; Nerve Degeneration; Org | 2011 |
Heterogeneous integration of adult-generated granule cells into the epileptic brain.
Topics: Adult Stem Cells; Animals; Animals, Newborn; Cation Transport Proteins; Cell Count; Dendrites; Dendr | 2011 |
Study of spontaneous recurrent seizures and morphological alterations after status epilepticus induced by intrahippocampal injection of pilocarpine.
Topics: Animals; Axons; Behavior, Animal; Brain; Chi-Square Distribution; Disease Models, Animal; Fluorescei | 2011 |
High-frequency (80-500 Hz) oscillations and epileptogenesis in temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Electroencephalography; Epilepsy, Temporal Lobe; Pil | 2011 |
Morphometry of hilar ectopic granule cells in the rat.
Topics: Animals; Dendrites; Dentate Gyrus; Electrophysiology; Male; Muscarinic Agonists; Neurons; Pilocarpin | 2011 |
Upregulation of Krüppel-like factor 6 in the mouse hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Gliosis; Hippocampus; Kruppel-Like Factor 6; Kruppel-Like Transcrip | 2011 |
Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model.
Topics: Animals; Anticonvulsants; Convulsants; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Poten | 2011 |
Group I mGluR-regulated translation of the neuronal glutamate transporter, excitatory amino acid carrier 1.
Topics: Animals; Blotting, Western; Convulsants; Dendrites; Dose-Response Relationship, Drug; Excitatory Ami | 2011 |
Pilocapine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1/2 mechanisms.
Topics: Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Hippocampus; Immunohistochemistry | 2011 |
Melatonin administration after pilocarpine-induced status epilepticus: a new way to prevent or attenuate postlesion epilepsy?
Topics: Analysis of Variance; Animals; Antioxidants; Cell Death; Disease Models, Animal; Hippocampus; Male; | 2011 |
Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Cell Shape; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, | 2011 |
The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus.
Topics: Animals; Cell Count; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Disease Models, Animal; Fluorescei | 2011 |
Status epilepticus-induced pathologic plasticity in a rat model of focal cortical dysplasia.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Malformations of Cortical Development; Methylazoxy | 2011 |
Neuroprotective effects of recombinant human erythropoietin in the developing brain of rat after lithium-pilocarpine induced status epilepticus.
Topics: Animals; Apoptosis; Convulsants; Erythropoietin; Hippocampus; Humans; In Situ Nick-End Labeling; Lit | 2012 |
Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Blood Glucose; Disease Models, Animal; Epilepsy, | 2011 |
P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus.
Topics: Acetamides; Adenosine Triphosphate; Animals; CA3 Region, Hippocampal; Male; Muscarinic Agonists; Neu | 2011 |
Lithium pilocarpine-induced status epilepticus in postnatal day 20 rats results in greater neuronal injury in ventral versus dorsal hippocampus.
Topics: Animals; Disease Models, Animal; Hippocampus; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, | 2011 |
Adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor gamma coactivator 1α signaling provides neuroprotection in status epilepticus in rats.
Topics: AMP-Activated Protein Kinases; Animals; Cell Count; Hippocampus; Ion Channels; Male; Mitochondrial P | 2011 |
Pilocarpine-induced status epilepticus alters hippocampal PKC expression in mice.
Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Electroencephalography; Female; G | 2011 |
Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm.
Topics: Animals; Chi-Square Distribution; Circadian Rhythm; Disease Models, Animal; Electroencephalography; | 2011 |
Seizure-induced structural and functional changes in the rat hippocampal formation: comparison between brief seizures and status epilepticus.
Topics: Animals; Avoidance Learning; Cell Count; Electroshock; Hippocampus; Male; Maze Learning; Nerve Degen | 2011 |
The roles of P2X7 receptor in regional-specific microglial responses in the rat brain following status epilepticus.
Topics: Adenosine Triphosphate; Animals; Brain; Disease Models, Animal; Gene Expression Regulation; Male; Mi | 2012 |
Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus.
Topics: Adenosine; Analysis of Variance; Animals; Brain; Cell Count; Disease Models, Animal; Drug Interactio | 2011 |
Decreased CREB levels suppress epilepsy.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cyclic AMP Response Element Modulator; | 2012 |
Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus.
Topics: Animals; Cell Death; Dose-Response Relationship, Drug; Hippocampus; Mice; Mice, Inbred Strains; Neur | 2012 |
Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Convulsants; Disease Models, Animal; Disease Pr | 2011 |
Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy.
Topics: Animals; Axons; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Green Fluore | 2011 |
Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bi | 2011 |
Mapping a mouse limbic seizure susceptibility locus on chromosome 10.
Topics: Animals; Chromosome Mapping; Convulsants; Genetic Predisposition to Disease; Genotype; Limbic System | 2011 |
Description and computational modeling of the whole course of status epilepticus induced by low dose lithium-pilocarpine in rats.
Topics: Animals; Brain; Computer Simulation; Convulsants; Electroencephalography; Lithium Compounds; Models, | 2011 |
Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus.
Topics: Animals; Disease Models, Animal; Ghrelin; Kainic Acid; Male; Oligopeptides; Peptides; Pilocarpine; R | 2011 |
The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Astrocytes; Benzamides; Cell Count; Cognition Disorders; Disease Mode | 2012 |
The 27-kDa heat shock protein (HSP27) is a reliable hippocampal marker of full development of pilocarpine-induced status epilepticus.
Topics: Animals; Hippocampus; HSP27 Heat-Shock Proteins; Male; Muscarinic Agonists; Pilocarpine; Rats; Statu | 2012 |
Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus.
Topics: Alprostadil; Animals; Blood-Testis Barrier; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Ele | 2011 |
Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Catalase; Cognition Disorders; D | 2011 |
Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy.
Topics: Abdominal Fat; Analysis of Variance; Animals; Chronic Disease; Disease Models, Animal; Energy Metabo | 2011 |
Neuron activation, degeneration and death in the hippocampus of mice after pilocarpine induced status epilepticus.
Topics: Animals; Cell Death; Hippocampus; Male; Mice; Nerve Degeneration; Neurons; Pilocarpine; Status Epile | 2011 |
Piperine protects epilepsy associated depression: a study on role of monoamines.
Topics: Alkaloids; Anhedonia; Animals; Anticonvulsants; Behavior, Animal; Benzodioxoles; Biogenic Monoamines | 2011 |
Pilocarpine-induced status epilepticus and subsequent spontaneous seizures: lack of effect on the number of gonadotropin-releasing hormone-positive neurons in a mouse model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Epilepsy, Temporal Lobe; Estrous Cycle; Female; Gonadotropin-Releasing Hormone; | 2012 |
Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus.
Topics: Animals; Antigens, Surface; Brain Edema; Cell Count; Chemokine CXCL2; Disease Models, Animal; Endoth | 2012 |
Corticotropin releasing factor (CRF) in the hippocampus of the mouse pilocarpine model of status epilepticus.
Topics: Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Hippocampus; Interneurons; Male; M | 2012 |
Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Convulsants; Dentate Gyrus; Electrophysiologica | 2012 |
Consequences of pilocarpine-induced status epilepticus in immunodeficient mice.
Topics: Animals; Brain; Cell Count; Cell Death; Glutamic Acid; Mice; Mice, Nude; Neurons; Pilocarpine; Proto | 2012 |
Behavioral and genetic effects promoted by sleep deprivation in rats submitted to pilocarpine-induced status epilepticus.
Topics: Animals; DNA Damage; Hyperkinesis; Male; Motor Activity; Pilocarpine; Rats; Rats, Wistar; Sleep Depr | 2012 |
Effect of mild hypothermia on glutamate receptor expression after status epilepticus.
Topics: Animals; Apoptosis; Blotting, Western; Cell Count; Diazepam; Electrodes, Implanted; Electroencephalo | 2012 |
Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus.
Topics: Animals; Chronic Disease; Excitatory Amino Acid Transporter 2; Hippocampus; Male; Mice; Mice, Transg | 2012 |
Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy.
Topics: Aggression; Animals; Behavior, Animal; Disease Models, Animal; Immunosuppressive Agents; Physical St | 2012 |
The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Epilepsy; Flavonoids; Lipid Peroxidation; Male; Neuroprotective | 2012 |
Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression.
Topics: Animals; Carrier Proteins; Homer Scaffolding Proteins; Male; Pilocarpine; Rats; Rats, Wistar; Recept | 2012 |
Increased perivascular laminin predicts damage to astrocytes in CA3 and piriform cortex following chemoconvulsive treatments.
Topics: Animals; Astrocytes; Basement Membrane; Blood Vessels; Brain; CA3 Region, Hippocampal; Convulsants; | 2012 |
Time-dependent modulation of mitogen activated protein kinases and AKT in rat hippocampus and cortex in the pilocarpine model of epilepsy.
Topics: Animals; Blotting, Western; Cerebral Cortex; Epilepsy; Hippocampus; Male; MAP Kinase Signaling Syste | 2012 |
MK-801 prevents overexpression of multidrug resistance protein 2 after status epilepticus.
Topics: Analysis of Variance; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette S | 2012 |
Changes in interictal spike features precede the onset of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Brain Mapping; Brain Waves; Disease Models, Animal; Electrodes; Electroe | 2012 |
Anticonvulsant effect of phytol in a pilocarpine model in mice.
Topics: Animals; Anticonvulsants; Male; Mice; Phytol; Pilocarpine; Seizures; Status Epilepticus; Survival Ra | 2012 |
Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus.
Topics: Animals; Anticholesteremic Agents; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Electro | 2012 |
Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats.
Topics: Animals; Aspirin; Cell Death; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2012 |
Hippocampal desynchronization of functional connectivity prior to the onset of status epilepticus in pilocarpine-treated rats.
Topics: Action Potentials; Animals; Electroencephalography Phase Synchronization; Hippocampus; Male; Nerve N | 2012 |
Reduction in delayed mortality and subtle improvement in retrograde memory performance in pilocarpine-treated mice with conditional neuronal deletion of cyclooxygenase-2 gene.
Topics: Animals; Cyclooxygenase 2; Enzyme Induction; Exploratory Behavior; Female; Gene Knockdown Techniques | 2012 |
Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus.
Topics: Analysis of Variance; Animals; Cell Death; Disease Models, Animal; Disease Progression; Fluoresceins | 2012 |
Morphological alterations in newly born dentate gyrus granule cells that emerge after status epilepticus contribute to make them less excitable.
Topics: Animals; Computer Simulation; Dendritic Cells; Dentate Gyrus; Ion Channels; Models, Neurological; Mo | 2012 |
Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus.
Topics: Animals; Calcium; Cells, Cultured; Convulsants; Hippocampus; Male; Neurons; Pilocarpine; Rats; Recep | 2012 |
Ketamine reduces neuronal degeneration and anxiety levels when administered during early life-induced status epilepticus in rats.
Topics: Animals; Anxiety; Brain; Convulsants; Ketamine; Male; Nerve Degeneration; Neuroprotective Agents; Pi | 2012 |
Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electrodes, Implanted; Entropy; Image Proc | 2012 |
CCL28 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus.
Topics: Animals; Base Sequence; Chemokines, CC; Dentate Gyrus; DNA Primers; Hippocampus; Immunohistochemistr | 2012 |
The reverse roles of transient receptor potential canonical channel-3 and -6 in neuronal death following pilocarpine-induced status epilepticus.
Topics: Animals; Cell Death; Male; Nerve Degeneration; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Sta | 2013 |
TGFβ1 treatment reduces hippocampal damage, spontaneous recurrent seizures, and learning memory deficits in pilocarpine-treated rats.
Topics: Administration, Intranasal; Animals; Apoptosis; Hippocampus; Lithium; Male; Maze Learning; Memory Di | 2013 |
A ketogenic diet did not prevent effects on the ectonucleotidases pathway promoted by lithium-pilocarpine-induced status epilepticus in rat hippocampus.
Topics: 5'-Nucleotidase; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; An | 2012 |
Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model.
Topics: Animals; Astrocytes; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Fingol | 2012 |
The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis.
Topics: Animals; CA1 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Excitatory Amino Acid Agoni | 2013 |
MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cell Death; Computational Biology; Disease Mode | 2012 |
Impact of corticosterone treatment on spontaneous seizure frequency and epileptiform activity in mice with chronic epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Corticosterone; Male; Mice; Mice, Inbred C57BL; Pilocarpine; Seiz | 2012 |
Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy--an X-ray fluorescence microscopy study.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Male; Microscopy, Fluorescenc | 2012 |
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
Topics: Animals; Anticonvulsants; Biomarkers; Cell Hypoxia; Cerebral Cortex; Convulsants; Diazepam; Disease | 2013 |
Transsynaptic signaling by activity-dependent cleavage of neuroligin-1.
Topics: Animals; Animals, Newborn; Biotinylation; Calcium-Binding Proteins; Cell Adhesion Molecules, Neurona | 2012 |
Activity-dependent proteolytic cleavage of neuroligin-1.
Topics: ADAM Proteins; ADAM10 Protein; Amyloid Precursor Protein Secretases; Animals; Animals, Newborn; Biot | 2012 |
Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin-1.
Topics: Animals; Axons; Cell Death; Cell Survival; Data Interpretation, Statistical; Female; Galectin 1; Imm | 2012 |
A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus.
Topics: Amides; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Elect | 2013 |
Alterations in hyperpolarization-activated cyclic nucleotidegated cation channel (HCN) expression in the hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Cyclic Nucleotide-Gated Cation Channels; Hippocampus; Hyperpolarization-Activated Cyclic Nu | 2012 |
Brain recruitment of dendritic cells following Li-pilocarpine induced status epilepticus in adult rats.
Topics: Animals; Blotting, Western; Brain; Convulsants; Dendritic Cells; Disease Models, Animal; Immunohisto | 2013 |
Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model.
Topics: Animals; Apoptosis; Atropine; Calpain; Chloral Hydrate; Disease Models, Animal; Hippocampus; Hypnoti | 2013 |
Are morphologic and functional consequences of status epilepticus in infant rats progressive?
Topics: Aggression; Aging; Animals; Animals, Newborn; Antimanic Agents; Atrophy; Behavior, Animal; Brain; Ce | 2013 |
Changes in microRNA expression in the whole hippocampus and hippocampal synaptoneurosome fraction following pilocarpine induced status epilepticus.
Topics: Animals; Gene Expression Regulation; Hippocampus; Microarray Analysis; MicroRNAs; Pilocarpine; Prote | 2013 |
Low-intensity physical training recovers object recognition memory impairment in rats after early-life induced Status epilepticus.
Topics: Animals; Behavior, Animal; Hippocampus; Male; Maze Learning; Memory Disorders; Physical Conditioning | 2013 |
Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells.
Topics: Action Potentials; Animals; Dentate Gyrus; GABA Agonists; GABAergic Neurons; gamma-Aminobutyric Acid | 2013 |
Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy.
Topics: Animals; Biomarkers; C-Reactive Protein; Electroencephalography; Enzyme-Linked Immunosorbent Assay; | 2013 |
Sexual response in female rats with status epilepticus.
Topics: Analysis of Variance; Animals; Corticosterone; Disease Models, Animal; Female; Gonadal Steroid Hormo | 2013 |
Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Disease Models, Animal; Hippocampus; Humans; I | 2013 |
Behavioral, morphologic, and electroencephalographic evaluation of seizures induced by intrahippocampal microinjection of pilocarpine.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Te | 2002 |
Epileptogenesis during development: injury, circuit recruitment, and plasticity.
Topics: Aging; Animals; Animals, Newborn; Convulsants; Dentate Gyrus; Electric Stimulation; Hippocampus; Imm | 2002 |
Characterization of reactive astrocytes in the chronic phase of the pilocarpine model of epilepsy.
Topics: Animals; Astrocytes; Brain; Chronic Disease; Convulsants; Gliosis; Male; Pilocarpine; Rats; Rats, Wi | 2002 |
Electrophysiologic abnormalities of the hippocampus in the pilocarpine/cycloheximide model of chronic spontaneous seizures.
Topics: Animals; Chronic Disease; Cycloheximide; Electrophysiology; Hippocampus; Male; Muscarinic Agonists; | 2002 |
Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure.
Topics: Animals; Axons; Cadherins; Immunoblotting; Immunohistochemistry; In Situ Hybridization; Male; Mossy | 2002 |
Long-lasting modification of intrinsic discharge properties in subicular neurons following status epilepticus.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Calcium Signaling; Cell Membrane; Dia | 2002 |
Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Chi-Square Distribution; Diazepam; Disease Models, Animal | 2002 |
The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anterior Thalamic Nuclei; Behavior, Animal; Disease Models, Animal; Male; Muscarinic Agonis | 2002 |
Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations.
Topics: Animals; Body Weight; Disease Models, Animal; Electroencephalography; Electrophysiology; Hippocampus | 2002 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; | 2002 |
Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus.
Topics: Acetylation; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Down-Regulation; En | 2002 |
Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain; Caspase 3; Caspases; Disease Models, Ani | 2002 |
Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model.
Topics: Age Factors; Animals; Brain Diseases; Cerebral Cortex; Disease Models, Animal; Entorhinal Cortex; Ep | 2002 |
Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Antidiuretic Hormone Receptor Antagonists; Arginine Vaso | 2002 |
Structural and functional asymmetry in the normal and epileptic rat dentate gyrus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Electrophysiology; Excitatory Amino Acid | 2002 |
Unaltered control of extracellular GABA-concentration through GAT-1 in the hippocampus of rats after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Extracellular Space; GABA Agonists; gamma-Aminobutyric Acid; Hippoc | 2003 |
Down-regulation of mGluR8 in pilocarpine epileptic rats.
Topics: Animals; Down-Regulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitat | 2003 |
Detection of late epilepsy by the texture analysis of MR brain images in the lithium-pilocarpine rat model.
Topics: Animals; Cerebral Cortex; Entorhinal Cortex; Epilepsy; Image Processing, Computer-Assisted; Lithium; | 2002 |
Magnetic resonance imaging of changes elicited by status epilepticus in the rat brain: diffusion-weighted and T2-weighted images, regional blood volume maps, and direct correlation with tissue and cell damage.
Topics: Amygdala; Animals; Brain; Brain Mapping; Cerebral Cortex; Gyrus Cinguli; Hippocampus; Image Enhancem | 2003 |
Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanism.
Topics: Animals; Cell Division; Dentate Gyrus; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Ser | 2003 |
Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Atropine Derivatives; Cell Count; Dentate Gyrus; Disease Models, Animal; | 2003 |
Epilepsy after early-life seizures can be independent of hippocampal injury.
Topics: Age Factors; Animals; Electroencephalography; Hippocampus; Lithium; Mossy Fibers, Hippocampal; Musca | 2003 |
Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent.
Topics: Aging; Animals; Brain; Cerebral Cortex; Disease Susceptibility; Lithium; Pilocarpine; Rats; Status E | 2003 |
Long-term effects of status epilepticus in the immature brain are specific for age and model.
Topics: Age Factors; Animals; Apoptosis; Convulsants; Electroencephalography; Hippocampus; Lithium Chloride; | 2003 |
Prolonged low-dose caffeine exposure protects against hippocampal damage but not against the occurrence of epilepsy in the lithium-pilocarpine model in the rat.
Topics: Age Factors; Animals; Anticonvulsants; Apoptosis; Caffeine; Convulsants; Disease Models, Animal; Dos | 2003 |
Long-term changes in susceptibility to pilocarpine-induced status epilepticus following neocortical injuries in the rat at different developmental stages.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain Injuries; Disease Susceptibility; Drug Res | 2003 |
Sprouting of mossy fibers and the vacating of postsynaptic targets in the inner molecular layer of the dentate gyrus.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Count; Cell Survival; Cycloheximide; Dentate Gyrus; D | 2003 |
Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells.
Topics: Animals; Dentate Gyrus; Electric Conductivity; Electric Stimulation; Fluorescent Dyes; Gene Expressi | 2003 |
Development of temporal lobe epilepsy in 21-day-old rats.
Topics: Age Factors; Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Magnetic Reso | 2003 |
Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat.
Topics: Animals; Anticonvulsants; Astrocytes; Brain; Cell Death; Cerebral Cortex; Convulsants; Electroenceph | 2003 |
Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain.
Topics: Animals; Brain; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antago | 2003 |
Nonlinear dynamic characteristics of electroencephalography in a high-dose pilocarpine-induced status epilepticus model.
Topics: Animals; Electroencephalography; Male; Nonlinear Dynamics; Pilocarpine; Rats; Rats, Sprague-Dawley; | 2003 |
Diazepam terminates brief but not prolonged seizures in young, naïve rats.
Topics: Age Factors; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; | 2003 |
Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus.
Topics: Animals; Animals, Newborn; Antazoline; Cell Count; Cells, Cultured; Cerebral Cortex; Disease Models, | 2003 |
[Acute alterations of neurotransmitters levels in striatum of young rat after pilocarpine-induced status epilepticus].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Female; Muscarinic Agonists; Neu | 2003 |
Effect of the postictal state on visual-spatial memory in immature rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Convulsant | 2003 |
Pilocarpine-induced seizures in adult rats: monoamine content and muscarinic and dopaminergic receptor changes in the striatum.
Topics: Animals; Biogenic Monoamines; Corpus Striatum; Disease Models, Animal; Female; Injections, Subcutane | 2003 |
Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizures.
Topics: Animals; Biotin; Cell Differentiation; Cell Movement; Choristoma; Dendrites; Dentate Gyrus; Electric | 2003 |
Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Blood Gas Analysis; Cell Death; Cerebral Cortex; Electroencephalography; Fructose; Hippocam | 2004 |
Long-term effects of early-life malnutrition and status epilepticus: assessment by spatial navigation and CREB(Serine-133) phosphorylation.
Topics: Animals; Animals, Newborn; Cell Death; Cyclic AMP Response Element-Binding Protein; Down-Regulation; | 2003 |
Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures.
Topics: Animals; Calcium-Binding Proteins; Calponins; Dendrites; Dentate Gyrus; Disease Models, Animal; Epil | 2003 |
Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Kindli | 2003 |
Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life.
Topics: Animals; Electroencephalography; Electrophysiology; Epilepsy, Absence; Female; Male; Muscarinic Agon | 2003 |
Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility.
Topics: Amino Acid Transport System X-AG; Animals; Cell Separation; Convulsants; Dentate Gyrus; Disease Mode | 2004 |
Status epilepticus-induced changes in the subcellular distribution and activity of calcineurin in rat forebrain.
Topics: Animals; Calcineurin; Calcium; Calcium Signaling; Cell Compartmentation; Cell Nucleus; Cerebral Cort | 2003 |
Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus.
Topics: Animals; Anterior Thalamic Nuclei; Disease Models, Animal; Electric Stimulation Therapy; Electroence | 2004 |
Fate of newborn dentate granule cells after early life status epilepticus.
Topics: Animals; Animals, Newborn; Cell Count; Dentate Gyrus; Pilocarpine; Rats; Status Epilepticus | 2004 |
Pilocarpine-induced status epilepticus increases glutamate release in rat hippocampal synaptosomes.
Topics: Animals; Glutamic Acid; Hippocampus; Male; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Syna | 2004 |
Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice.
Topics: Animals; Blotting, Western; Brain; Densitometry; Disease Models, Animal; Immunohistochemistry; Male; | 2004 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep | 2004 |
Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Antagonists; Hippoca | 2004 |
Effects of status epilepticus on hippocampal GABAA receptors are age-dependent.
Topics: Age Factors; Animals; Animals, Newborn; Blotting, Northern; Cell Survival; Cerebral Cortex; Dose-Res | 2004 |
Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats.
Topics: Animals; Cell Count; Dentate Gyrus; Electroencephalography; Epilepsy, Temporal Lobe; Immunohistochem | 2004 |
Long-term behavioral and morphological consequences of nonconvulsive status epilepticus in rats.
Topics: Animals; Arousal; Behavior, Animal; Brain; Brain Damage, Chronic; Brain Mapping; Calbindins; Convuls | 2004 |
Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; GAP-43 Protein; Growth Cone | 2004 |
Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Division; Cytarabine; Disease M | 2004 |
Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis.
Topics: Age Factors; Animals; Behavior, Animal; Body Weight; Brain; Cognition Disorders; Electroencephalogra | 2004 |
Pilocarpine-induced status epilepticus in rats: lipid peroxidation level, nitrite formation, GABAergic and glutamatergic receptor alterations in the hippocampus, striatum and frontal cortex.
Topics: Animals; Corpus Striatum; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus; Lipid Peroxidation; Ma | 2004 |
Strain differences affect the induction of status epilepticus and seizure-induced morphological changes.
Topics: Animals; Cell Count; Hippocampus; Male; Mossy Fibers, Hippocampal; Neurons; Pilocarpine; Rats; Rats, | 2004 |
Catalase activity in cerebellum, hippocampus, frontal cortex and striatum after status epilepticus induced by pilocarpine in Wistar rats.
Topics: Animals; Cerebellum; Corpus Striatum; Frontal Lobe; Hippocampus; Male; Pilocarpine; Rats; Rats, Wist | 2004 |
Neuroethological study of status epilepticus induced by systemic pilocarpine in Wistar audiogenic rats (WAR strain).
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Reflex; Limbic Sy | 2004 |
Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Division; Dentate Gyrus; Disease Models, Anim | 2004 |
Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis.
Topics: Animals; Biological Transport; Brain-Derived Neurotrophic Factor; Cell Compartmentation; Convulsants | 2004 |
Status epilepticus induced by pilocarpine and Ca2+ transport by microsome in the hippocampus of rats.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Biological Transport; Calcium; Calcium-Transp | 2004 |
Differential neuroprotective effects of the NMDA receptor-associated glycine site partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine in lithium-pilocarpine status epilepticus.
Topics: Amino Acids, Cyclic; Animals; Antimetabolites; Brain; Cycloserine; Electrodes, Implanted; Electroenc | 2004 |
Postnatal maturation of cytochrome oxidase and lactate dehydrogenase activity and age-dependent consequences of lithium-pilocarpine status epilepticus in the rat: a regional histoenzymology study.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Electron Transport Complex IV; Female; Glucose; L-Lac | 2004 |
Neuronal and glial cell populations in the piriform cortex distinguished by using an approximation of q-space imaging after status epilepticus.
Topics: Amygdala; Animals; Cell Death; Convulsants; Diffusion Magnetic Resonance Imaging; Disease Models, An | 2004 |
Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice.
Topics: Animals; Dentate Gyrus; Drug Combinations; Electric Stimulation; Hippocampus; Kainic Acid; Lithium C | 2004 |
Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats.
Topics: Aggression; Animals; Animals, Newborn; Behavior, Animal; Cell Count; Cell Death; Cells, Cultured; El | 2004 |
Monoamine levels after pilocarpine-induced status epilepticus in hippocampus and frontal cortex of Wistar rats.
Topics: Analysis of Variance; Animals; Biogenic Monoamines; Brain Chemistry; Chromatography, High Pressure L | 2004 |
In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat.
Topics: Animals; Brain; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Lithium; Male; Muscari | 2004 |
The mechanism of neuroprotection by topiramate in an animal model of epilepsy.
Topics: Animals; Brain; Cell Survival; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Dru | 2004 |
Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Epilepsy, Temporal Lobe; Inflammation; Interleuki | 2004 |
Cognitive impairment following status epilepticus and recurrent seizures during early development: support for the "two-hit hypothesis".
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cell Death; Cognition Disorders; | 2004 |
Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Cross-Over Studies; Disease Models, Animal; Dose-Response | 2005 |
Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Benzazepines; Bicuculline; Convulsants; Dentate Gyru | 2005 |
Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Synergism; Epilepsy; Foc | 2005 |
Oxidative stress in the hippocampus after pilocarpine-induced status epilepticus in Wistar rats.
Topics: Animals; Catalase; Glutathione; Hippocampus; Lipid Peroxidation; Motor Activity; Oxidative Stress; P | 2005 |
Neocortical and hippocampal changes after multiple pilocarpine-induced status epilepticus in rats.
Topics: Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Disease Models, Animal; Hippocampus; Immunob | 2005 |
Effects of pinealectomy and the treatment with melatonin on the temporal lobe epilepsy in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Denervation; Disease Models, Animal; Epilepsy, Temporal Lobe; H | 2005 |
Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Blotting, Western; Brain; Calcium; Calcium-Calmodulin | 2005 |
Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus.
Topics: Animals; Benzenesulfonates; Brain; Cyclic N-Oxides; Disease Models, Animal; Electroencephalography; | 2005 |
Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Behavior, Animal; Calcium-Binding Proteins; Dentate Gyrus; DNA-Binding Proteins; Electroenc | 2005 |
Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity.
Topics: Amygdala; Animals; Brain; CHO Cells; Cricetinae; Down-Regulation; Galanin; Gene Expression; Hippocam | 2005 |
Hippocampal granule cell activity and c-Fos expression during spontaneous seizures in awake, chronically epileptic, pilocarpine-treated rats: implications for hippocampal epileptogenesis.
Topics: Action Potentials; Animals; Cell Count; Evoked Potentials; Hippocampus; Male; Neural Inhibition; Neu | 2005 |
Disruption of cortical development as a consequence of repetitive pilocarpine-induced status epilepticus in rats.
Topics: Animals; Apoptosis; Behavior, Animal; Cerebral Cortex; Glutamate Decarboxylase; Immunohistochemistry | 2005 |
Changes of cortical interhemispheric responses after status epilepticus in immature rats.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Electric Stimulation; Fluoresceins; Fluorescent Dyes; Fun | 2005 |
Outcome of status epilepticus in immature rats varies according to the paraldehyde treatment.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Body Weight; Dose-Response Relationshi | 2005 |
Changes in cytochrome oxidase in the piriform cortex after status epilepticus in adult rats.
Topics: Animals; Brain Mapping; Cerebral Cortex; Electron Transport Complex IV; Lithium Chloride; Male; Neur | 2005 |
Plastic changes and disease-modifying effects of scopolamine in the pilocarpine model of epilepsy in rats.
Topics: Acetylcholinesterase; Animals; Dentate Gyrus; Disease Models, Animal; Male; Mossy Fibers, Hippocampa | 2005 |
Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide.
Topics: Animals; Chronic Disease; Cycloheximide; Densitometry; Dentate Gyrus; Disease Models, Animal; GAP-43 | 2005 |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Topics: 5'-Nucleotidase; Adenosine; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2005 |
Proechimys guyannensis: an animal model of resistance to epilepsy.
Topics: Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy; Hippo | 2005 |
Volumetric magnetic resonance imaging of functionally relevant structural alterations in chronic epilepsy after pilocarpine-induced status epilepticus in rats.
Topics: Animals; Behavior, Animal; Brain; Hippocampus; Magnetic Resonance Imaging; Male; Maze Learning; Memo | 2005 |
Prolonged infusion of cycloheximide does not block mossy fiber sprouting in a model of temporal lobe epilepsy.
Topics: Animals; Cycloheximide; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; | 2005 |
[Age difference of the activation of apoptotic cascade reaction following LiCl-pilocarpine status epilepticus].
Topics: Age Factors; Animals; Apoptosis; Caspase 3; Caspases; Female; Hippocampus; Lithium Chloride; Male; N | 2005 |
Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine.
Topics: Animals; Convulsants; Disease Models, Animal; Disease Susceptibility; Estrogens; Estrous Cycle; Fema | 2005 |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drin | 2005 |
Modulation of CaM kinase II activity is coincident with induction of status epilepticus in the rat pilocarpine model.
Topics: Animals; Behavior, Animal; Brain Mapping; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calciu | 2005 |
Congenital brain dysplasias of different genesis can differently affect susceptibility to pilocarpine- or kainic acid-induced seizures in the rat.
Topics: Animals; Behavior, Animal; Brain Diseases; Convulsants; Dose-Response Relationship, Drug; Electroenc | 2005 |
Arginine vasopressin does not contribute to seizures induced by intracerebroventricularly-injected pilocarpine.
Topics: Animals; Arginine Vasopressin; Convulsants; Dose-Response Relationship, Drug; Injections, Intraventr | 2005 |
Neo-Timm staining in the thalamus of chronically epileptic rats.
Topics: Acetylcholinesterase; Animals; Brain Mapping; Chronic Disease; Male; Nerve Endings; Pilocarpine; Rat | 2005 |
Effect of neonatal isolation on outcome following neonatal seizures in rats--the role of corticosterone.
Topics: Animals; Animals, Newborn; Behavior, Animal; Convulsants; Corticosterone; Cyclic AMP Response Elemen | 2006 |
Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine.
Topics: Animals; Convulsants; Disease Models, Animal; DNA Damage; DNA, Mitochondrial; Electron Transport Com | 2006 |
Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy, T | 2005 |
Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results.
Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Hippocampus; Lovastatin; Male; Muscarinic A | 2005 |
Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats.
Topics: Age Factors; Animals; Autoreceptors; Chronic Disease; Entorhinal Cortex; Epilepsy, Generalized; Exci | 2006 |
Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects.
Topics: Animals; Anticonvulsants; Atropine; Diazepam; Dose-Response Relationship, Drug; Electroencephalograp | 2006 |
Newly born dentate granule neurons after pilocarpine-induced epilepsy have hilar basal dendrites with immature synapses.
Topics: Animals; Astrocytes; Dendrites; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; H | 2006 |
Acetylcholinesterase activities in hippocampus, frontal cortex and striatum of Wistar rats after pilocarpine-induced status epilepticus.
Topics: Acetylcholinesterase; Animals; Corpus Striatum; Frontal Lobe; Hippocampus; Male; Pilocarpine; Rats; | 2006 |
Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus.
Topics: Animals; Brain; Cell Death; Cerebral Cortex; eIF-2 Kinase; Epilepsy, Temporal Lobe; Hippocampus; Mic | 2006 |
Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: a histologic and MRI study.
Topics: Amygdala; Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Entorhinal Cortex; Fluoresce | 2006 |
EAAC1 glutamate transporter expression in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Brain; Brain Chemistry; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 3; Fluor | 2006 |
Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.
Topics: Aging; Animals; Animals, Newborn; Auditory Perception; Brain Mapping; Cell Survival; Discrimination | 2005 |
Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Activation; Focal Adhesion Kinase 2; Guan | 2006 |
Effects of uridine in models of epileptogenesis and seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroencephalography; Hippocam | 2006 |
Erythropoietin preconditioning on hippocampus neuronal apoptosis following status epilepticus induced by Li-pilocarpine in rats through anti-caspase-3 expression.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Disease | 2006 |
Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Cholesterol Side-Chain | 2006 |
Effect of glycemic state in rats submitted to status epilepticus during development.
Topics: Age Factors; Animals; Cell Count; Disease Models, Animal; Glucose Transporter Type 3; Glycemic Index | 2006 |
Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; Cell Count; Cell Proliferation; Dentate Gyrus; Glial Fibrillary Acidic Protein; | 2006 |
Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus.
Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Female; gamma-Aminobutyric Acid; | 2006 |
Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus.
Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal; Hippocampus; Male; Muscarinic | 2006 |
Status epilepticus differentially alters AMPA and kainate receptor subunit expression in mature and immature dentate granule neurons.
Topics: Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Dentate Gyrus; Disease Models, Ani | 2006 |
Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy.
Topics: Adenosine Triphosphatases; Animals; Astrocytes; Brain; Convulsants; Dentate Gyrus; Disease Models, A | 2006 |
Assessment of the progressive nature of cell damage in the pilocarpine model of epilepsy.
Topics: Animals; Cell Death; Disease Models, Animal; Limbic System; Male; Muscarinic Agonists; Neurons; Pilo | 2006 |
Physical training decreases susceptibility to subsequent pilocarpine-induced seizures in the rat.
Topics: Animals; Female; Male; Physical Conditioning, Animal; Physical Exertion; Pilocarpine; Rats; Rats, Wi | 2006 |
Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Body Temperature; Brain; Chemical Warfare Agents; Cholin | 2006 |
Depression and/or potentiation of cortical responses after status epilepticus in immature rats.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electroencephalography; Evok | 2007 |
Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures.
Topics: Analysis of Variance; Animals; Cell Survival; Disease Models, Animal; Fluoresceins; gamma-Aminobutyr | 2006 |
The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Therapy, Combination; Electroenceph | 2006 |
Effect of gabaergic, glutamatergic, antipsychotic and antidepressant drugs on pilocarpine-induced seizures and status epilepticus.
Topics: Amines; Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2006 |
Pharmacological studies of the opioids, mood stabilizer and dopaminergic drugs on pilocarpine-induced seizures and status epilepticus.
Topics: Analgesics, Opioid; Animals; Antimanic Agents; Dopamine Antagonists; Haloperidol; Lithium Chloride; | 2006 |
Effect of levetiracetam on visual-spatial memory following status epilepticus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cell Death; Disease Models, Animal; Electroencephalograp | 2007 |
CRE-mediated transcription and COX-2 expression in the pilocarpine model of status epilepticus.
Topics: Animals; Astrocytes; Blotting, Western; Cell Line; Cyclic AMP Response Element-Binding Protein; Cycl | 2007 |
Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat.
Topics: Algorithms; Animals; Behavior, Animal; Cell Count; Cell Size; Cytoplasmic Granules; Dentate Gyrus; H | 2006 |
Increased GABA(A)-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus.
Topics: Animals; Animals, Newborn; Dentate Gyrus; Gene Expression; Hippocampus; Kainic Acid; Lithium; Nuclei | 2006 |
Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Fructo | 2007 |
Neuroprotectants FK-506 and cyclosporin A ameliorate the course of pilocarpine-induced seizures.
Topics: Animals; Behavior, Animal; Cyclosporine; Male; Neuroprotective Agents; Pilocarpine; Rats; Rats, Wist | 2007 |
Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat.
Topics: Animals; Anticonvulsants; Brain Damage, Chronic; Carbamazepine; Convulsants; Disease Models, Animal; | 2006 |
Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Astrocytes; Cell Survival; Convulsants; Erythropoietin; Hippocampus; Macro | 2007 |
CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus.
Topics: Animals; Dose-Response Relationship, Drug; Gene Expression Regulation; Hippocampus; Male; Mice; Pilo | 2007 |
Preferential neuron loss in the rat piriform cortex following pilocarpine-induced status epilepticus.
Topics: Animals; Cell Death; Cerebral Cortex; Cholecystokinin; Disease Models, Animal; Immunohistochemistry; | 2007 |
Ca(v)1.2, Ca(v)1.3, and Ca(v)2.1 in the mouse hippocampus during and after pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium-Binding Proteins; C | 2007 |
The Na+/K+ATPase activity is increased in the hippocampus after multiple status epilepticus induced by pilocarpine in developing rats.
Topics: Aging; Animals; Animals, Newborn; Hippocampus; Pilocarpine; Rats; Rats, Wistar; Recurrence; Sodium-P | 2007 |
Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Excitato | 2007 |
Dissociation of the immunoreactivity of synaptophysin and GAP-43 during the acute and latent phases of the lithium-pilocarpine model in the immature and adult rat.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain; Disease Models, Animal; GAP-43 Prot | 2007 |
Monitoring of acute generalized status epilepticus using multilocal diffusion MR imaging: early prediction of regional neuronal damage.
Topics: Acute Disease; Animals; Brain; Brain Mapping; Cell Death; Diffusion Magnetic Resonance Imaging; Dise | 2007 |
Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus.
Topics: Animals; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Hippocampus; Humans; Lithium | 2007 |
Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats.
Topics: Animals; Catalase; Disease Models, Animal; Drug Interactions; Enzyme Activation; Hippocampus; Male; | 2007 |
Treatment of late lithium-pilocarpine-induced status epilepticus with diazepam.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Diazepam; Electroencephalography; Lithium C | 2007 |
Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzoates; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationsh | 2007 |
Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy.
Topics: Animals; Autoradiography; Benzoxazines; Densitometry; Epitopes; Fluorescent Antibody Technique; Guan | 2007 |
Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain.
Topics: Animals; Animals, Newborn; Autophagy; Brain; Caspase 3; Cell Death; Disease Models, Animal; Dizocilp | 2007 |
Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat.
Topics: Animals; Behavior, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Male; Muscarinic Agonist | 2007 |
Loss of input from the mossy cells blocks maturation of newly generated granule cells.
Topics: Animals; Anticonvulsants; Biomarkers; Bromodeoxyuridine; Calbindin 2; Cell Differentiation; Cell Pro | 2007 |
Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Ga | 2007 |
Anti-glutamatergic effect of riluzole: comparison with valproic acid.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; Excitatory Posts | 2007 |
Vitamin C antioxidant effects in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpine.
Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Dose-Response Relationship, Drug; Hippocampus; Lipid | 2007 |
Involvement of nitric oxide in spatial memory deficits in status epilepticus rats.
Topics: Animals; Glutathione Peroxidase; Guanidines; Hippocampus; Indazoles; Male; Malondialdehyde; Maze Lea | 2007 |
Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study.
Topics: Action Potentials; Animals; Cell Death; Convulsants; Cortical Synchronization; Disease Models, Anima | 2007 |
Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures.
Topics: Action Potentials; Animals; Biomarkers; Calbindins; Calcitonin Gene-Related Peptide; Choristoma; Con | 2007 |
Acute and chronic changes in glycogen phosphorylase in hippocampus and entorhinal cortex after status epilepticus in the adult male rat.
Topics: Animals; Convulsants; Data Interpretation, Statistical; Entorhinal Cortex; Glycogen Phosphorylase; H | 2007 |
Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells.
Topics: Animals; Axons; Cell Death; Cell Division; Cell Movement; Cellular Senescence; Dendrites; Dentate Gy | 2007 |
Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Dose-Response Relationship, Radiation; Down-Regul | 2007 |
In vivo and in vitro effects of pilocarpine: relevance to ictogenesis.
Topics: Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Electroencephalography; Guinea Pigs; Hi | 2007 |
Effects of noninvasive transcutaneous electrical stimulation via concentric ring electrodes on pilocarpine-induced status epilepticus in rats.
Topics: Animals; Behavior, Animal; Control Groups; Disease Models, Animal; Electrodes; Electroencephalograph | 2007 |
Erythropoietin preconditioning suppresses neuronal death following status epilepticus in rats.
Topics: Analysis of Variance; Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; BH3 Interacting | 2007 |
Glutamate binding is altered in hippocampus and cortex of Wistar rats after pilocarpine-induced Status Epilepticus.
Topics: Animals; Binding Sites; Cerebral Cortex; Convulsants; Epilepsy; Glutamic Acid; Hippocampus; Ligands; | 2007 |
An enriched environment improves cognitive performance after early-life status epilepticus accompanied by an increase in phosphorylation of extracellular signal-regulated kinase 2.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cognition; Disease Models, Animal | 2007 |
Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Diazepam; Disease Models, Animal; D | 2007 |
Acute and chronic responses to the convulsant pilocarpine in DBA/2J and A/J mice.
Topics: Animals; Brain Chemistry; Convulsants; DNA-Binding Proteins; Electrodes, Implanted; Electroencephalo | 2007 |
Inflammation exacerbates seizure-induced injury in the immature brain.
Topics: Acute Disease; Animals; Animals, Newborn; Body Temperature; Brain; Cell Count; Disease Models, Anima | 2007 |
Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Autoradiography; Cell Count; Cerebral Cortex; Deoxygluco | 2007 |
Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus.
Topics: Animals; Anticonvulsants; Astrocytes; Calcium; Calcium Signaling; Cell Death; Chelating Agents; Dise | 2007 |
Effects of LiCl/pilocarpine-induced status epilepticus on rat brain mu and benzodiazepine receptor binding: regional and ontogenetic studies.
Topics: Age Factors; Analysis of Variance; Animals; Brain; Disease Models, Animal; Lithium Chloride; Pilocar | 2007 |
[Effects of cyclin dependent protein kinase inhibitor olomoucine on the neuronal apoptosis after status epilepticus: experiment with rats].
Topics: Animals; Apoptosis; Brain; Cyclin B; Cyclin B1; Cyclin-Dependent Kinases; Enzyme Inhibitors; Fluores | 2007 |
A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation.
Topics: Animals; Cerebral Cortex; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2008 |
Brain metabolism and diffusion in the rat cerebral cortex during pilocarpine-induced status epilepticus.
Topics: Animals; Body Water; Brain Chemistry; Cerebral Cortex; Diffusion Magnetic Resonance Imaging; Electro | 2008 |
Pilocarpine-induced status epilepticus in rats involves ischemic and excitotoxic mechanisms.
Topics: Animals; Brain; Endothelium, Vascular; Gliosis; Image Processing, Computer-Assisted; Ischemia; Magne | 2007 |
Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus.
Topics: Animals; Blood Vessels; Cell Death; Convulsants; Enzyme-Linked Immunosorbent Assay; Hippocampus; Imm | 2008 |
Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus.
Topics: Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Electric Stimulation; Electroencephalogra | 2008 |
Effects of early-life LiCl-pilocarpine-induced status epilepticus on memory and anxiety in adult rats are associated with mossy fiber sprouting and elevated CSF S100B protein.
Topics: Age Factors; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Fear; Hippocampus; Lithium Chlori | 2008 |
Changes of cortical epileptic afterdischarges after status epilepticus in immature rats.
Topics: Aging; Animals; Cerebral Cortex; Convulsants; Electric Stimulation; Electroencephalography; Epilepsy | 2008 |
Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus.
Topics: Animals; Biotinylation; Disease Models, Animal; Endocytosis; Enzyme Inhibitors; Hippocampus; Immunop | 2008 |
Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dopamine; Dose-Response Relatio | 2008 |
Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Disease Models, Animal; | 2008 |
Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus.
Topics: Animals; Benzamides; Cell Death; Convulsants; Disease Models, Animal; Glutathione; Heme Oxygenase (D | 2008 |
Inflammation modifies status epilepticus-induced hippocampal injury during development.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Hippocampus; Inflammation; Kainic Acid; Li | 2007 |
Effective treatments of prolonged status epilepticus in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, | 2008 |
Potential role of pyridoxal-5'-phosphate phosphatase/chronopin in epilepsy.
Topics: Actin Cytoskeleton; Actin Depolymerizing Factors; Animals; Cloning, Molecular; Disease Models, Anima | 2008 |
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Capill | 2008 |
Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Knockout; Pilocarpine; Status E | 2008 |
Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus.
Topics: Animals; Blotting, Western; Calbindin 1; Calbindins; Calcium; Hippocampus; Immunohistochemistry; Mal | 2008 |
Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Antipsychotic Agents; Apoptosis Inducing Factor; BH3 Interacting Domain Death Agonist Prote | 2008 |
Mossy fiber sprouting in pilocarpine-induced status epilepticus rat hippocampus: a correlative study of diffusion spectrum imaging and histology.
Topics: Animals; Anisotropy; Diffusion Magnetic Resonance Imaging; Imaging, Three-Dimensional; Male; Mossy F | 2008 |
Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats.
Topics: Animals; Benzamides; Blotting, Western; Brain Injuries; CD40 Antigens; Central Nervous System Diseas | 2008 |
Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Shape; Convulsants; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tempor | 2008 |
A cellular mechanism for dendritic spine loss in the pilocarpine model of status epilepticus.
Topics: Actins; Analysis of Variance; Animals; Brain; Calcineurin; Dendrites; Dendritic Spines; Disease Mode | 2008 |
Erythropoietin reduces epileptogenic processes following status epilepticus.
Topics: Analysis of Variance; Animals; Brain; Bromodeoxyuridine; Capillary Permeability; CD11b Antigen; Cell | 2008 |
Effect of TTX suppression of hippocampal activity following status epilepticus.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Electroencephalography; H | 2008 |
The extracellular matrix protein SC1/hevin localizes to excitatory synapses following status epilepticus in the rat lithium-pilocarpine seizure model.
Topics: Animals; Blotting, Western; Brain; Calcium-Binding Proteins; Extracellular Matrix Proteins; Image Pr | 2008 |
Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cell Death; Electric Stimulation; Entorhinal Cortex; Epilepsy, Temporal L | 1995 |
Selective inhibition of axon outgrowth by antibodies to NGF in a model of temporal lobe epilepsy.
Topics: Animals; Antibodies; Axons; Cholinergic Fibers; Epilepsy, Temporal Lobe; Male; Nerve Fibers; Nerve G | 1995 |
Changes in gene expression of AMPA-selective glutamate receptor subunits induced by status epilepticus in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Base Sequence; Blotting, Northern | 1994 |
Long-term behavioral deficits following pilocarpine seizures in immature rats.
Topics: Animals; Behavior, Animal; Electroencephalography; Hippocampus; Male; Pilocarpine; Rats; Rats, Sprag | 1994 |
Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats.
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy; Hippocampus; Histocytochemistr | 1995 |
Cardiac hypertrophy secondary to status epilepticus in the rat.
Topics: Animals; Body Weight; Cardiomegaly; Diazepam; Dizocilpine Maleate; Electroencephalography; Lithium C | 1995 |
Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Complex Partial; | 1995 |
Functional mapping of the early stages of status epilepticus: a 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Electro | 1995 |
Functional mapping of the late stages of status epilepticus in the lithium-pilocarpine model in rat: a 14C-2-deoxyglucose study.
Topics: Animals; Brain Mapping; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Lithium; Male; P | 1995 |
Neuroprotective effect of ketamine administered after status epilepticus onset.
Topics: Amygdala; Animals; Brain; Cell Death; Electroencephalography; Frontal Lobe; Injections, Intraperiton | 1995 |
Loss of immunoreactivity for glial fibrillary acidic protein (GFAP) in astrocytes as a marker for profound tissue damage in substantia nigra and basal cortical areas after status epilepticus induced by pilocarpine in rat.
Topics: Animals; Astrocytes; Biomarkers; Cerebral Cortex; Glial Fibrillary Acidic Protein; Immunohistochemis | 1994 |
Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats.
Topics: Animals; Cell Line; Cerebral Cortex; Corpus Striatum; Gene Expression Regulation; Glial Cell Line-De | 1994 |
The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Electroenc | 1994 |
Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine.
Topics: Animals; Anisomycin; Cerebral Ventricles; Cycloheximide; Electroencephalography; Hippocampus; Inject | 1994 |
Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury?
Topics: Animals; Apoptosis; Brain Ischemia; Dizocilpine Maleate; Genes, fos; Genes, jun; Haloperidol; Hypoxi | 1993 |
Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury.
Topics: Acepromazine; Animals; Body Temperature Regulation; Brain Injuries; Chlorides; Hypothermia; Limbic S | 1993 |
Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat.
Topics: Animals; Axons; Biomarkers; Brain Injuries; Cerebral Infarction; Immunoenzyme Techniques; Lactates; | 1993 |
GABA metabolism in the substantia nigra, cortex, and hippocampus during status epilepticus.
Topics: Amino Acids; Aminocaproates; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Hippocampus; Lithium | 1993 |
MK-801 sensitizes rats to pilocarpine induced limbic seizures and status epilepticus.
Topics: Animals; Atropine; Diazepam; Dizocilpine Maleate; Drug Synergism; Electroencephalography; Limbic Sys | 1993 |
Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Felbam | 1993 |
Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy.
Topics: Animals; Dinoprost; Dinoprostone; Disease Models, Animal; Epilepsy; Hippocampus; Male; Muscarinic Ag | 1995 |
Change in neurotrophins and their receptor mRNAs in the rat forebrain after status epilepticus induced by pilocarpine.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Gene Expression; Hippocampus; In Situ H | 1996 |
Regional changes in brain dopamine utilization during status epilepticus in the rat induced by systemic pilocarpine and intrahippocampal carbachol.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Carbachol; Dopamine; Homovanillic Acid; Male; Muscar | 1996 |
Differential expression of inducible transcription factors in basal ganglia neurons.
Topics: Animals; Basal Ganglia; Corpus Striatum; Dopamine Antagonists; Haloperidol; Immunohistochemistry; Ma | 1995 |
Protective effects of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Baclofen; Clonazepam; Diazepam; Dizocilpine Maleate; Ethanol; GABA Agents; | 1996 |
Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus.
Topics: Animals; Base Sequence; Brain-Derived Neurotrophic Factor; Cell Death; Fluorescent Antibody Techniqu | 1996 |
The pilocarpine model of epilepsy in mice.
Topics: Animals; Coloring Agents; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; E | 1996 |
The temporal evolution of neuronal damage from pilocarpine-induced status epilepticus.
Topics: Animals; Brain Diseases; Hippocampus; Male; Neurons; Pilocarpine; Rats; Rats, Wistar; Status Epilept | 1996 |
Expression of 9-O-acetylated gangliosides in the rat hippocampus.
Topics: Acetylation; Age Factors; Animals; Animals, Newborn; Antibodies, Monoclonal; Cell Movement; Ganglios | 1996 |
Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats.
Topics: Animals; Cerebral Cortex; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Male; Neuronal | 1996 |
Induction of astroglial gene expression by experimental seizures in the rat: spatio-temporal patterns of the early stages.
Topics: Animals; Astrocytes; Behavior, Animal; Brain; Brain Chemistry; Convulsants; Excitatory Amino Acid Ag | 1996 |
Developmental aspects of the pilocarpine model of epilepsy.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Disease Models, Animal; Epilepsy; Male; Pilocarpine; | 1996 |
GABA metabolism during status epilepticus in the developing rat brain.
Topics: Age Factors; Animals; gamma-Aminobutyric Acid; Hippocampus; Lithium; Muscarinic Agonists; Parietal L | 1997 |
Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.
Topics: Animals; Anticonvulsants; Clonazepam; Desoxycorticosterone; Dose-Response Relationship, Drug; Excita | 1996 |
Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cell Movement; Dentate Gyrus; Elect | 1997 |
Blockade of spreading depression in chronic epileptic rats: reversion by diazepam.
Topics: Animals; Anticonvulsants; Chronic Disease; Cortical Spreading Depression; Diazepam; Electroencephalo | 1997 |
Lithium-pilocarpine status epilepticus in the immature rabbit.
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Hippocampus; Lithium Carbonate; Neur | 1997 |
Status epilepticus induced by pilocarpine and picrotoxin.
Topics: Amygdala; Animals; Convulsants; Male; Parasympathomimetics; Picrotoxin; Pilocarpine; Rats; Rats, Wis | 1997 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Fos-like immunoreactivity after status epilepticus and spontaneous seizures in rats.
Topics: Animals; Brain; Brain Mapping; Gene Expression; Male; Muscarinic Agonists; Pilocarpine; Proto-Oncoge | 1996 |
Laminar damage of neurons and astrocytes in neocortex and hippocampus of rat after long-lasting status epilepticus induced by pilocarpine.
Topics: Animals; Astrocytes; Brain Damage, Chronic; Brain Mapping; Cerebral Cortex; Glial Fibrillary Acidic | 1996 |
Reduced cortical ecto-ATPase activity in rat brains during prolonged status epilepticus induced by sequential administration of lithium and pilocarpine.
Topics: Adenosine Triphosphatases; Analysis of Variance; Animals; Cerebral Cortex; Chronic Disease; Drug Adm | 1997 |
Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents.
Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Carbamazepine; Dipyridamole; Disease Models, | 1997 |
Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats.
Topics: Animals; Atropine; Brain Diseases; Lithium; Male; Nimodipine; Pilocarpine; Rats; Rats, Wistar; Seizu | 1997 |
Dopaminergic modulation of lithium/pilocarpine-induced status epilepticus in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Azepines; Benzazepines; Disease | 1997 |
NMDA receptor activation during status epilepticus is required for the development of epilepsy.
Topics: Animals; Cell Count; Dizocilpine Maleate; Electroencephalography; Epilepsy; Excitatory Amino Acid An | 1998 |
Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats.
Topics: Animals; Behavior, Animal; Brain Injuries; Electroencephalography; Lithium; Male; Neurons; Pilocarpi | 1998 |
Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Hippo | 1998 |
GABA(A) receptor function in epileptic human dentate granule cells: comparison to epileptic and control rat.
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; GABA Agonists; GABA Antagonists; gamma-Aminobutyric | 1998 |
Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy.
Topics: Animals; Epilepsy; Estradiol; Estrus; Female; Fertility; Follicle Stimulating Hormone; Humans; Lutei | 1998 |
Patterns of status epilepticus-induced neuronal injury during development and long-term consequences.
Topics: Age Factors; Animals; Apoptosis; Behavior, Animal; DNA; Electroencephalography; Female; In Situ Nick | 1998 |
Tyrosine phosphorylation is increased in the rat hippocampus during the status epilepticus induced by pilocarpine.
Topics: Animals; Blotting, Western; Disease Models, Animal; Hippocampus; Immunohistochemistry; Male; Phospho | 1998 |
Status epilepticus causes long-term NMDA receptor-dependent behavioral changes and cognitive deficits.
Topics: Animals; Behavior, Animal; Cognition; Electroencephalography; Memory; Pilocarpine; Rats; Receptors, | 1998 |
C-Fos, Jun D and HSP72 immunoreactivity, and neuronal injury following lithium-pilocarpine induced status epilepticus in immature and adult rats.
Topics: Age Factors; Animals; Brain Stem; Cerebral Cortex; Female; Heat-Shock Proteins; Hippocampus; HSP72 H | 1998 |
Remodeling dendritic spines in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Cell Size; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Ionto | 1998 |
Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Glucose; Lactic Acid; Lithium; Male; Nerv | 1999 |
Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Dentate Gyrus; Elect | 1999 |
The course of untreated seizures in the pilocarpine model of epilepsy.
Topics: Animals; Behavior, Animal; Disease Progression; Electroencephalography; Epilepsy; Incidence; Muscari | 1999 |
Lithium-pilocarpine-induced status epilepticus produces necrotic neurons with internucleosomal DNA fragmentation in adult rats.
Topics: Age Factors; Animals; Apoptosis; Cell Nucleolus; Dentate Gyrus; DNA Fragmentation; In Situ Nick-End | 1999 |
Altered residual ATP content in rat brain cortex subcellular fractions following status epilepticus induced by lithium and pilocarpine.
Topics: Adenosine Triphosphate; Animals; Cell Fractionation; Cell Membrane; Cerebral Cortex; Cytosol; Hydrol | 1998 |
Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus.
Topics: Action Potentials; Animals; Brain-Derived Neurotrophic Factor; Cell Size; Epilepsy; Excitatory Posts | 1999 |
N-methyl-D-aspartate receptor activation regulates refractoriness of status epilepticus to diazepam.
Topics: Animals; Anticonvulsants; Diazepam; Dizocilpine Maleate; Drug Resistance; Electroencephalography; Ex | 1999 |
Cognitive functions after pilocarpine-induced status epilepticus: changes during silent period precede appearance of spontaneous recurrent seizures.
Topics: Animals; Cell Count; Clonazepam; Cognition; Hippocampus; Ketamine; Male; Maze Learning; Memory; Pilo | 1999 |
Zinc inhibition of gamma-aminobutyric acid(A) receptor function is decreased in the cerebral cortex during pilocarpine-induced status epilepticus.
Topics: Animals; Biological Transport; Cerebellum; Cerebral Cortex; Chlorides; GABA Agonists; GABA-A Recepto | 1999 |
Persistent increased DNA-binding and expression of serum response factor occur with epilepsy-associated long-term plasticity changes.
Topics: Animals; Brain; Cell Nucleus; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; DNA-Binding Proteins | 1999 |
Differential regulation of cytokine expression following pilocarpine-induced seizure.
Topics: Animals; Cell Death; Ciliary Neurotrophic Factor; Cytokines; Gene Expression Regulation; Gliosis; Gr | 1999 |
Effect of long-term spontaneous recurrent seizures or reinduction of status epilepticus on the development of supragranular mossy fiber sprouting.
Topics: Animals; Cycloheximide; Male; Mossy Fibers, Hippocampal; Muscarinic Agonists; Pilocarpine; Protein S | 1999 |
Selective alterations of glycosaminoglycans synthesis and proteoglycan expression in rat cortex and hippocampus in pilocarpine-induced epilepsy.
Topics: Animals; Cerebral Cortex; Chondroitin Sulfates; Epilepsy; Glycosaminoglycans; Heparitin Sulfate; Hip | 1999 |
Status epilepticus results in an N-methyl-D-aspartate receptor-dependent inhibition of Ca2+/calmodulin-dependent kinase II activity in the rat.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Electroencephalography; Isoenzymes; Ph | 2000 |
Lithium plus pilocarpine induced status epilepticus--biochemical changes.
Topics: Animals; Brain; Female; Lithium; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus | 2000 |
Epileptogenesis in immature rats following recurrent status epilepticus.
Topics: Age Factors; Animals; Anxiety; Avoidance Learning; Brain; Electroencephalography; Exploratory Behavi | 2000 |
Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticus.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Kainic Acid; Male; Neurons; Pilocarpine; Rats; Rats, | 2000 |
Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus.
Topics: Animals; Behavior, Animal; Brain Mapping; Cell Count; Cell Death; Fluorescent Dyes; Gliosis; Hippoca | 2000 |
Cell damage and neurogenesis in the dentate granule cell layer of adult rats after pilocarpine- or kainate-induced status epilepticus.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cycloheximide; Excitatory Amino Acid Agonists; Kainic A | 2000 |
Interstrain differences in cognitive functions in rats in relation to status epilepticus.
Topics: Animals; Hippocampus; Male; Maze Learning; Muscarinic Agonists; Pilocarpine; Rats; Rats, Long-Evans; | 2000 |
Ultrastructural identification of dentate granule cell death from pilocarpine-induced seizures.
Topics: Animals; Cytoplasmic Granules; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Human | 2000 |
Pilocarpine-induced status epilepticus causes N-methyl-D-aspartate receptor-dependent inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake.
Topics: Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Cytosol; Kinetics; Male; Microsomes; Pilocarpine; Rats; Rats | 2000 |
Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy.
Topics: Animals; Astrocytes; Brain; Cell Death; Electroencephalography; Entorhinal Cortex; Gliosis; Hippocam | 2000 |
Chronic inhibition of Ca(2+)/calmodulin kinase II activity in the pilocarpine model of epilepsy.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Inhibitors | 2000 |
Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Lipid Pe | 2000 |
Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Down-Regulation; Electrophysiology; Electroshock; Immunoh | 2000 |
Seizure-induced neuronal necrosis: implications for programmed cell death mechanisms.
Topics: Animals; Apoptosis; Brain; Cell Nucleolus; Coloring Agents; DNA Damage; In Situ Nick-End Labeling; K | 2000 |
Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Lysine; Male; Mo | 2000 |
The role of mossy cell death and activation of protein synthesis in the sprouting of dentate mossy fibers: evidence from calretinin and neo-timm staining in pilocarpine-epileptic mice.
Topics: Animals; Calbindin 2; Cell Death; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tempor | 2000 |
A metabolic and neuropathological approach to the understanding of plastic changes that occur in the immature and adult rat brain during lithium-pilocarpine-induced epileptogenesis.
Topics: Age Factors; Animals; Brain; Female; Glucose; Lithium; Male; Nerve Degeneration; Neuronal Plasticity | 2000 |
Granule cell neurogenesis after status epilepticus in the immature rat brain.
Topics: Animals; Brain; Cell Division; Dentate Gyrus; Electric Stimulation; Hippocampus; Injections, Intrape | 2000 |
Multiple pilocarpine-induced status epilepticus in developing rats: a long-term behavioral and electrophysiological study.
Topics: Age Factors; Animals; Apoptosis; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; E | 2000 |
Does status epilepticus influence the motor development of immature rats?
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Exploratory Behavi | 2000 |
The lesional and epileptogenic consequences of lithium-pilocarpine-induced status epilepticus are affected by previous exposure to isolated seizures: effects of amygdala kindling and maximal electroshocks.
Topics: Amygdala; Animals; Disease Models, Animal; Electroencephalography; Electroshock; Kindling, Neurologi | 2000 |
Temporal changes in neuronal dropout following inductions of lithium/pilocarpine seizures in the rat.
Topics: Animals; Brain; Cell Survival; Lithium; Male; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, | 2000 |
Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Arginine; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2000 |
Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry.
Topics: Animals; Dendrites; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Micr | 2000 |
Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth.
Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Cyclopropanes; Extracellular Space; GABA A | 2000 |
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cell Count; Choline; Choline O-Acetyltransfe | 2000 |
Patterns of status epilepticus-induced substance P expression during development.
Topics: Age Factors; Animals; Dizocilpine Maleate; Female; Hippocampus; Lithium Chloride; Male; Neural Pathw | 2000 |
Nonconvulsive status epilepticus in rats: impaired responsiveness to exteroceptive stimuli.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Electroencephalography; Epilepsia Partiali | 2000 |
Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Topics: Action Potentials; Age Factors; Animals; Behavior, Animal; Cell Count; Chronic Disease; Dentate Gyru | 2001 |
Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Male; Muscarinic Agonist | 2001 |
An animal model of nonconvulsive status epilepticus: a contribution to clinical controversies.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Hippocampus; Humans; Lith | 2001 |
Reduced excitatory drive onto interneurons in the dentate gyrus after status epilepticus.
Topics: Action Potentials; Animals; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Excitatory | 2001 |
Brain-derived neurotrophic factor superinduction parallels anti-epileptic--neuroprotective treatment in the pilocarpine epilepsy model.
Topics: Animals; Brain-Derived Neurotrophic Factor; Diazepam; Gene Expression Regulation; Hippocampus; Male; | 2001 |
Lithium does not synergize the peripheral action of cholinomimetics as seen in the central nervous system.
Topics: Acetylcholine; Animals; Blood Pressure; Brain; Cholinergic Agents; Dose-Response Relationship, Drug; | 2001 |
Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Apoptosis; Avian Proteins; Basigin; Bl | 2001 |
Lack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsy.
Topics: Action Potentials; Animals; Dendrites; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Amin | 2001 |
Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calcium; Cell Survival; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluorescent Dyes; | 2001 |
Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells.
Topics: Action Potentials; Animals; Biotin; Cell Size; Cell Survival; Cortical Synchronization; Dendrites; E | 2001 |
A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus.
Topics: Animals; Brain; Calcineurin; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Hippocamp | 2001 |
Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Syne | 2001 |
Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats.
Topics: Animals; Chronic Disease; Epilepsy; Glutathione Peroxidase; Hippocampus; Hydrogen Peroxide; Male; Mu | 2001 |
Expression of metabotropic glutamate receptor 1alpha in the hippocampus of rat pilocarpine model of status epilepticus.
Topics: Animals; Blotting, Western; Hippocampus; Immunohistochemistry; Male; Microscopy, Immunoelectron; Pil | 2001 |
Effect of duration of pilocarpine-induced status epilepticus on subsequent cognitive function in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Diazepam; Male; Muscarinic Agonists; Pilocarpine; Rats | 2001 |
Differential regulation of basic helix-loop-helix mRNAs in the dentate gyrus following status epilepticus.
Topics: Animals; Annexins; Basic Helix-Loop-Helix Transcription Factors; Bromodeoxyuridine; Caenorhabditis e | 2001 |
Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation.
Topics: Action Potentials; Animals; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Ago | 2001 |
Caspase inhibitors increase short-term survival of progenitor-cell progeny in the adult rat dentate gyrus following status epilepticus.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Caspase Inhibitors; Cell Count; Cell Survival; Convulsa | 2001 |
Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss.
Topics: Aging; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Lithium; Male; | 2001 |
Weight gain in post-seized rats is facilitated by adding aspirin, glucose, or glucose-taurine-acetaminophen to food mush.
Topics: Acepromazine; Acetaminophen; Animals; Aspirin; Glucose; Hypothalamic Area, Lateral; Injections, Subc | 2001 |
Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Cerebrovascular Circulation; Drug Synergi | 2002 |
Acquisition and retrieval of conditioned taste aversion is impaired by brain damage caused by two hours of pilocarpine-induced status epilepticus.
Topics: Animals; Avoidance Learning; Conditioning, Psychological; Hippocampus; Male; Memory; Muscarinic Agon | 2001 |
Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus.
Topics: Aging; Animals; Animals, Newborn; Antimanic Agents; Brain; Caspase 3; Caspases; Cholinergic Agents; | 2002 |
Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; bcl-2-Associated X Protein; Carbon-Oxygen Lyases; C | 2002 |
Aminophylline aggravates long-term morphological and cognitive damages in status epilepticus in immature rats.
Topics: Aging; Aminophylline; Animals; Cell Differentiation; Cognition Disorders; Growth Cones; Hippocampus; | 2002 |
Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Disease Models, Animal; | 2002 |
Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Division; Cell Movement; Cerebral Ventricles; Genes, Re | 2002 |
Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus.
Topics: Animals; Calbindins; Cell Count; Dentate Gyrus; Male; Neurons; Neuropeptide Y; Parvalbumins; Pilocar | 2002 |
Upregulation of a T-type Ca2+ channel causes a long-lasting modification of neuronal firing mode after status epilepticus.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Separation; Dis | 2002 |
Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice.
Topics: Animals; Cell Death; Convulsants; Dentate Gyrus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strain | 2002 |
Glucose utilisation during status epilepticus in an epilepsy model induced by pilocarpine: a qualitative study.
Topics: Animals; Antimetabolites; Autoradiography; Brain; Deoxyglucose; Disease Models, Animal; Energy Metab | 2002 |
Hydroethidine detection of superoxide production during the lithium-pilocarpine model of status epilepticus.
Topics: Animals; Brain; Ethidium; Lithium; Male; Phenanthridines; Pilocarpine; Rats; Rats, Wistar; Reactive | 2002 |
The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures.
Topics: Aminoacetonitrile; Animals; Blotting, Western; Cell Death; Disease Models, Animal; Enzyme Activation | 2002 |
Granule cell dispersion in relation to mossy fiber sprouting, hippocampal cell loss, silent period and seizure frequency in the pilocarpine model of epilepsy.
Topics: Animals; Cell Count; Cytoplasmic Granules; Electroencephalography; Epilepsy, Temporal Lobe; Hippocam | 1992 |
Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats.
Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Chlorides; Drug Administration Schedule; Electroe | 1992 |
Transient suppression of a secondary humoral response in rats is evoked by lithium-pilocarpine-induced limbic seizures.
Topics: Adrenocorticotropic Hormone; Animals; Antibody Formation; Cyclophosphamide; Limbic System; Lithium; | 1992 |
Seizures selectively impair agonist-stimulated phosphoinositide hydrolysis without affecting protein kinase C activity in rat brain.
Topics: Animals; Brain; Disease Models, Animal; Hippocampus; Hydrolysis; In Vitro Techniques; Lithium; Male; | 1992 |
Neurochemical changes in the hippocampus of rats with spontaneous recurrent seizures.
Topics: Amino Acids; Animals; Dopamine; Electroencephalography; Epilepsies, Partial; Hippocampus; Male; Moto | 1992 |
Corpus callosotomy in the lithium-pilocarpine model of seizures and status epilepticus.
Topics: Animals; Corpus Callosum; Electroencephalography; Hippocampus; Histocytochemistry; Lithium; Pilocarp | 1992 |
A rodent model of focally evoked self-sustaining status epilepticus.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Electroencephalography; Lithium; Male; Piloc | 1992 |
[3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine.
Topics: Acetylcholine; Animals; Cerebral Cortex; Chlorides; Choline; Hemicholinium 3; Hippocampus; Kinetics; | 1991 |
Damage of substantia nigra pars reticulata during pilocarpine-induced status epilepticus in the rat: immunohistochemical study of neurons, astrocytes and serum-protein extravasation.
Topics: Animals; Astrocytes; Biomarkers; Blood Proteins; Corpus Striatum; Female; Glial Fibrillary Acidic Pr | 1991 |
Motor and electroencephalographic response of refractory experimental status epilepticus in rats to treatment with MK-801, diazepam, or MK-801 plus diazepam.
Topics: Animals; Behavior, Animal; Diazepam; Dizocilpine Maleate; Drug Interactions; Electroencephalography; | 1991 |
Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Electroencephalography; gamma-Aminobutyric Acid; Glutama | 1990 |
Learning impairment in chronic epileptic rats following pilocarpine-induced status epilepticus.
Topics: Animals; Behavior, Animal; Brain; Learning; Male; Memory; Pilocarpine; Rats; Rats, Inbred Strains; S | 1990 |
GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures.
Topics: Animals; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Male; N | 1990 |
Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; | 1989 |
Chronic lithium treatment and status epilepticus induced by lithium and pilocarpine cause selective changes of amino acid concentrations in rat brain regions.
Topics: Amino Acids; Animals; Brain; Cerebral Cortex; Corpus Striatum; Hippocampus; Lithium; Male; Pilocarpi | 1989 |
Status epilepticus is produced by administration of cholinergic agonists to lithium-treated rats: comparison with kainic acid.
Topics: Animals; Arecoline; Chlorides; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalogra | 1987 |
Neurochemical consequences of status epilepticus induced in rats by coadministration of lithium and pilocarpine.
Topics: Acetylcholine; Animals; Brain; Choline; Cyclic GMP; Decerebrate State; Drug Combinations; Lithium; M | 1986 |
Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam.
Topics: Analysis of Variance; Animals; Diazepam; Electroencephalography; Lithium; Pilocarpine; Reaction Time | 1988 |
Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats.
Topics: Animals; Anticonvulsants; Atropine; Diazepam; Electroencephalography; Lithium; Male; Paraldehyde; Ph | 1987 |
Acetylcholine content in rat brain is elevated by status epilepticus induced by lithium and pilocarpine.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Brain; Choline; Lithium; Male; Pilocarpine; | 1987 |
Status epilepticus facilitated by pilocarpine in amygdala-kindled rats.
Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pilocarpine; Rats; Ra | 1986 |
Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats.
Topics: Animals; Atropine; Diazepam; Drug Synergism; Electroencephalography; Hemicholinium 3; Lithium; Male; | 1986 |