Page last updated: 2024-11-08

pilocarpine and Abdominal Epilepsy

pilocarpine has been researched along with Abdominal Epilepsy in 14 studies

Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.

Research Excerpts

ExcerptRelevanceReference
"Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe."7.73Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006)
"Pilocarpine-treated animals, which did not develop status epilepticus, showed no change in growth-associated phosphoprotein levels, indicating that status epilepticus is important to induce growth-associated phosphoprotein overexpression."5.30Growth-associated phosphoprotein expression is increased in the supragranular regions of the dentate gyrus following pilocarpine-induced seizures in rats. ( Cavalheiro, EA; Funke, MG; Naffah-Mazzacoratti, MG; Sanabria, ER, 1999)
"Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe."3.73Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006)
"In the present study glutamate decarboxylase immunoreactivity (GAD-IR) was used to quantify GABAergic neurons in the hippocampus of rats exhibiting spontaneous recurrent seizures following pilocarpine-induced status epilepticus."3.68GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures. ( Cavalheiro, EA, 1990)
"Interictal activity and seizures are the hallmarks of focal epileptic disorders (which include mesial temporal lobe epilepsy, MTLE) in humans and in animal models."3.01Evolution of interictal activity in models of mesial temporal lobe epilepsy. ( Avoli, M; Lévesque, M; Macey-Dare, ADB; Salami, P; Wang, S, 2023)
" hM4Di has no effect in the absence of its selective, normally inactive and orally bioavailable agonist clozapine-N-oxide (CNO)."1.40Chemical-genetic attenuation of focal neocortical seizures. ( Kätzel, D; Kullmann, DM; Nicholson, E; Schorge, S; Walker, MC, 2014)
"Pilocarpine-treated animals, which did not develop status epilepticus, showed no change in growth-associated phosphoprotein levels, indicating that status epilepticus is important to induce growth-associated phosphoprotein overexpression."1.30Growth-associated phosphoprotein expression is increased in the supragranular regions of the dentate gyrus following pilocarpine-induced seizures in rats. ( Cavalheiro, EA; Funke, MG; Naffah-Mazzacoratti, MG; Sanabria, ER, 1999)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (28.57)18.2507
2000's6 (42.86)29.6817
2010's3 (21.43)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Lévesque, M1
Wang, S1
Macey-Dare, ADB1
Salami, P1
Avoli, M1
Yi, PL2
Lu, CY2
Cheng, CH1
Tsai, YF1
Lin, CT1
Chang, FC2
Kätzel, D1
Nicholson, E1
Schorge, S1
Walker, MC1
Kullmann, DM1
Jou, SB1
Trindade-Filho, EM1
de Castro-Neto, EF1
de A Carvalho, R1
Lima, E1
Scorza, FA1
Amado, D1
Naffah-Mazzacoratti, Mda G1
Cavalheiro, EA4
Xia, Y1
Lai, Y1
Lei, L1
Liu, Y1
Yao, D1
Kohane, DS1
Holmes, GL1
Chau, Y1
Zurakowski, D1
Langer, R1
Cha, BH1
Meurs, A1
Clinckers, R1
Ebinger, G2
Michotte, Y2
Smolders, I2
Milh, M1
Becq, H1
Villeneuve, N1
Ben-Ari, Y1
Aniksztejn, L1
Naffah-Mazzacoratti, MG1
Funke, MG1
Sanabria, ER1
Lindekens, H1
Khan, GM1
Bialer, M1
Fernandes, MJ1
Turski, L1
Mazzacoratti, MG1
Fine, A1
Meldrum, BS1
Patel, S1

Reviews

1 review available for pilocarpine and Abdominal Epilepsy

ArticleYear
Evolution of interictal activity in models of mesial temporal lobe epilepsy.
    Neurobiology of disease, 2023, Volume: 180

    Topics: Animals; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans; Pil

2023

Other Studies

13 other studies available for pilocarpine and Abdominal Epilepsy

ArticleYear
Amygdala opioid receptors mediate the electroacupuncture-induced deterioration of sleep disruptions in epilepsy rats.
    Journal of biomedical science, 2013, Nov-12, Volume: 20

    Topics: Amygdala; Animals; Electroacupuncture; Epilepsies, Partial; Male; Naloxone; Narcotic Antagonists; Pi

2013
Chemical-genetic attenuation of focal neocortical seizures.
    Nature communications, 2014, May-27, Volume: 5

    Topics: Acute Disease; Animals; Clozapine; Epilepsies, Partial; Gene Silencing; Genetic Therapy; Humans; Mal

2014
Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Journal of biomedical science, 2015, Jul-07, Volume: 22

    Topics: Animals; Electroacupuncture; Electroencephalography; Epilepsies, Partial; Humans; Naloxone; Pilocarp

2015
Serotonin depletion effects on the pilocarpine model of epilepsy.
    Epilepsy research, 2008, Volume: 82, Issue:2-3

    Topics: 5,7-Dihydroxytryptamine; Acute Disease; Animals; Behavior, Animal; Chronic Disease; Disease Models,

2008
Left hemisphere predominance of pilocarpine-induced rat epileptiform discharges.
    Journal of neuroengineering and rehabilitation, 2009, Nov-30, Volume: 6

    Topics: Animals; Azides; Cerebral Cortex; Disease Models, Animal; Epilepsies, Partial; Functional Laterality

2009
Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures.
    Epilepsia, 2002, Volume: 43, Issue:12

    Topics: Animals; Anticonvulsants; Drug Carriers; Drug Implants; Epilepsies, Partial; GABA-A Receptor Agonist

2002
Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures.
    Epilepsia, 2006, Volume: 47, Issue:9

    Topics: Animals; Anticonvulsants; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response

2006
Inhibition of glutamate transporters results in a "suppression-burst" pattern and partial seizures in the newborn rat.
    Epilepsia, 2007, Volume: 48, Issue:1

    Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cerebral Cortex; Disease

2007
Growth-associated phosphoprotein expression is increased in the supragranular regions of the dentate gyrus following pilocarpine-induced seizures in rats.
    Neuroscience, 1999, Volume: 91, Issue:2

    Topics: Animals; Dentate Gyrus; Epilepsies, Partial; GAP-43 Protein; Immunohistochemistry; Male; Phosphoprot

1999
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy.
    Pharmaceutical research, 2000, Volume: 17, Issue:11

    Topics: Amides; Animals; Anti-Anxiety Agents; Anticonvulsants; Epilepsies, Partial; gamma-Aminobutyric Acid;

2000
Neurochemical changes in the hippocampus of rats with spontaneous recurrent seizures.
    Epilepsy research. Supplement, 1992, Volume: 9

    Topics: Amino Acids; Animals; Dopamine; Electroencephalography; Epilepsies, Partial; Hippocampus; Male; Moto

1992
GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1990, Volume: 23, Issue:6-7

    Topics: Animals; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Male; N

1990
Modulation of experimentally induced epilepsy by intracerebral grafts of fetal GABAergic neurons.
    Neuropsychologia, 1990, Volume: 28, Issue:6

    Topics: Animals; Brain Mapping; Caudate Nucleus; Epilepsies, Partial; Fetus; Kindling, Neurologic; Male; Ner

1990