pifithrin has been researched along with Subarachnoid Hemorrhage in 4 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, adult rats were divided into 3 groups: sham (n=21), nontreatment (subarachnoid hemorrhage [SAH]+dimethyl sulfoxide; n=42), and treatment (SAH+pifithrin-alpha) (n=42) groups." | 3.73 | Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage. ( Cahill, J; Calvert, JW; Solaroglu, I; Zhang, JH, 2006) |
| "The mechanism of cerebral vasospasm following subarachnoid haemorrhage (SAH) is not understood." | 1.35 | Pifithrin-alpha reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat. ( Chen, CH; Hu, Q; Luan, LJ; Qin, LH; Shi, XZ; Yan, JH; Yang, L; Yang, XM; Zhao, J; Zhou, CM, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, JH | 2 |
| Khatibi, NH | 1 |
| Han, HB | 1 |
| Hu, Q | 2 |
| Chen, CH | 2 |
| Li, L | 1 |
| Yang, XM | 2 |
| Zhou, CM | 2 |
| Zhou, C | 1 |
| Yamaguchi, M | 1 |
| Colohan, AR | 1 |
| Zhang, JH | 2 |
| Cahill, J | 1 |
| Calvert, JW | 1 |
| Solaroglu, I | 1 |
| Zhao, J | 1 |
| Shi, XZ | 1 |
| Luan, LJ | 1 |
| Yang, L | 1 |
| Qin, LH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of New Neuroinflammation Markers in Subarachnoid Haemorrhage Patients: a Pilot Study[NCT03411746] | 60 participants (Actual) | Observational | 2018-01-26 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for pifithrin and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
p53-induced uncoupling expression of aquaporin-4 and inwardly rectifying K+ 4.1 channels in cytotoxic edema after subarachnoid hemorrhage.
Topics: Animals; Aquaporin 4; Benzothiazoles; Brain Edema; Gene Expression Regulation; Hippocampus; Male; Po | 2012 |
Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Basilar Artery; Benzothiazoles; Blotting, Western; Brain; Cerebral Angiography; | 2005 |
Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage.
Topics: Animals; Apoptosis Regulatory Proteins; Basilar Artery; Benzothiazoles; Blood-Brain Barrier; Blottin | 2006 |
Pifithrin-alpha reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat.
Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Disease Models, Animal; Endothelial Cells; Ma | 2008 |