pifithrin has been researched along with Seizures in 4 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " By day 1, and extending through 4 days following kainic acid-induced seizures, brains from DNA-PKcs null mice showed widespread neurodegeneration that encompassed the entire hippocampal CA1-CA3 pyramidal cell layer, entorhinal cortex, and lateral septum, with relative sparing of the dentate gyrus granule cell layer and hilus, as judged by toluidine blue, Fluoro-Jade B, and terminal dUTP nick end labeling staining." | 7.73 | DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. ( Chechlacz, M; Gilliams-Francis, K; Lamonica, K; Lin, SL; Liu, J; Naegele, JR; Navarro-Quiroga, I; Neema, M, 2005) |
| " By day 1, and extending through 4 days following kainic acid-induced seizures, brains from DNA-PKcs null mice showed widespread neurodegeneration that encompassed the entire hippocampal CA1-CA3 pyramidal cell layer, entorhinal cortex, and lateral septum, with relative sparing of the dentate gyrus granule cell layer and hilus, as judged by toluidine blue, Fluoro-Jade B, and terminal dUTP nick end labeling staining." | 3.73 | DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. ( Chechlacz, M; Gilliams-Francis, K; Lamonica, K; Lin, SL; Liu, J; Naegele, JR; Navarro-Quiroga, I; Neema, M, 2005) |
| "Because seizures activate p53, and p53-deficient mice are reportedly resistant to damage caused by prolonged seizures, we investigated the role of miR-34a in seizure-induced neuronal death in vivo." | 1.38 | MicroRNA-34a upregulation during seizure-induced neuronal death. ( Henshall, DC; Jimenez-Mateos, EM; Matsushima, S; Reynolds, JP; Sano, T; Taki, W, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, DC | 1 |
| Lee, KY | 1 |
| Lizarazo, S | 1 |
| Cook, JK | 1 |
| Tsai, NP | 1 |
| Sano, T | 1 |
| Reynolds, JP | 1 |
| Jimenez-Mateos, EM | 1 |
| Matsushima, S | 1 |
| Taki, W | 1 |
| Henshall, DC | 1 |
| Neema, M | 1 |
| Navarro-Quiroga, I | 1 |
| Chechlacz, M | 1 |
| Gilliams-Francis, K | 1 |
| Liu, J | 1 |
| Lamonica, K | 1 |
| Lin, SL | 1 |
| Naegele, JR | 1 |
| Culmsee, C | 1 |
| Zhu, X | 1 |
| Yu, QS | 1 |
| Chan, SL | 1 |
| Camandola, S | 1 |
| Guo, Z | 1 |
| Greig, NH | 1 |
| Mattson, MP | 1 |
4 other studies available for pifithrin and Seizures
| Article | Year |
|---|---|
ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model.
Topics: Animals; Benzothiazoles; Endoplasmic Reticulum Stress; Fragile X Mental Retardation Protein; Fragile | 2021 |
MicroRNA-34a upregulation during seizure-induced neuronal death.
Topics: Animals; Apoptosis; Argonaute Proteins; Benzothiazoles; Hippocampus; Immunoprecipitation; Kainic Aci | 2012 |
DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures.
Topics: Animals; Benzothiazoles; Cell Death; Cells, Cultured; DNA Damage; DNA Repair; DNA-Activated Protein | 2005 |
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.
Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Ca | 2001 |