pifithrin has been researched along with Reperfusion Injury in 12 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3'-UTR: 3-untranslated region; CIR: cerebral ischemia-reperfusion; CIS: cerebral ischemic stroke; PFT-α: Pifithrin-α; PVDF: polyvinylidene fluoride; SD: Sprague-Dawley; TBST: tris buffered saline with tween." | 3.88 | MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53. ( Jing, L; Xie, YL; Zhang, B, 2018) |
| "PFT-α inhibited neurological deficits, brain infarct volume, neuroinflammation, apoptosis, and BBB integrity than the MCAO/R rats; however, this inhibition was reversed by DKK1." | 1.91 | PFT-α protects the blood-brain barrier through the Wnt/β-catenin pathway after acute ischemic stroke. ( Du, D; Gao, X; Li, Z; Liu, P; Tian, X; Wang, B; Xu, Y; Yang, S; Zhang, H, 2023) |
| "Renal ischemia-reperfusion injury is a leading cause of acute kidney injury; the pathogenesis of which remains poorly understood and effective therapies are still lacking." | 1.46 | Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6. ( Dong, Z; Hao, J; Li, L; Mei, C; Mei, S; Su, Y; Wei, Q, 2017) |
| "Renal ischemia reperfusion injury is known to shorten telomeres and upregulate stress-induced genes, such as the cyclin-dependent kinase (CDK) inhibitor p21." | 1.34 | p21 and mTERT are novel markers for determining different ischemic time periods in renal ischemia-reperfusion injury. ( Heininger, D; Hochegger, K; Huber, JM; Koppelstaetter, C; Mayer, G; Rosenkranz, AR; Tagwerker, A, 2007) |
| "Pifithrin-alpha was protective when given up to 14 h after the ischemic insult." | 1.32 | P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. ( Dagher, PC; Kelly, KJ; Plotkin, Z; Vulgamott, SL, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Du, D | 1 |
| Gao, X | 1 |
| Tian, X | 1 |
| Xu, Y | 1 |
| Wang, B | 1 |
| Yang, S | 1 |
| Liu, P | 2 |
| Li, Z | 1 |
| Xie, YL | 1 |
| Zhang, B | 1 |
| Jing, L | 1 |
| Pfaff, MJ | 1 |
| Mukhopadhyay, S | 1 |
| Hoofnagle, M | 1 |
| Chabasse, C | 1 |
| Sarkar, R | 1 |
| Li, X | 1 |
| Gu, S | 1 |
| Ling, Y | 1 |
| Shen, C | 1 |
| Cao, X | 1 |
| Xie, R | 1 |
| Hao, J | 1 |
| Wei, Q | 1 |
| Mei, S | 1 |
| Li, L | 1 |
| Su, Y | 1 |
| Mei, C | 1 |
| Dong, Z | 1 |
| Sutton, TA | 2 |
| Wilkinson, J | 1 |
| Mang, HE | 1 |
| Knipe, NL | 1 |
| Plotkin, Z | 3 |
| Hosein, M | 1 |
| Zak, K | 1 |
| Wittenborn, J | 1 |
| Dagher, PC | 3 |
| Li, Y | 1 |
| Liu, X | 1 |
| Rong, F | 1 |
| Hato, T | 1 |
| Mai, E | 1 |
| Yoshimoto, M | 1 |
| Kuehl, S | 1 |
| Anderson, M | 1 |
| Mang, H | 1 |
| Chan, RJ | 1 |
| Kelly, KJ | 1 |
| Vulgamott, SL | 1 |
| Strosznajder, RP | 1 |
| Jesko, H | 1 |
| Banasik, M | 1 |
| Tanaka, S | 1 |
| Hochegger, K | 1 |
| Koppelstaetter, C | 1 |
| Tagwerker, A | 1 |
| Huber, JM | 1 |
| Heininger, D | 1 |
| Mayer, G | 1 |
| Rosenkranz, AR | 1 |
| Xu, B | 1 |
| Cavalieri, TA | 1 |
| Hock, CE | 1 |
12 other studies available for pifithrin and Reperfusion Injury
| Article | Year |
|---|---|
PFT-α protects the blood-brain barrier through the Wnt/β-catenin pathway after acute ischemic stroke.
Topics: Animals; beta Catenin; Blood-Brain Barrier; Brain Infarction; Endothelial Cells; Fluorescein; Ischem | 2023 |
MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Brain Infarction; Brain Ischemia; Ca | 2018 |
Tumor suppressor protein p53 negatively regulates ischemia-induced angiogenesis and arteriogenesis.
Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Benzothiazoles; Blood Flow Velocity; | 2018 |
p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling.
Topics: Animals; Benzothiazoles; Cells, Cultured; Female; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective | 2015 |
Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Caspases; Cell Line; Disease Models, Animal | 2017 |
p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Benzothiazoles; Cell Line; Hypoxia-Inducible Factor 1, alpha Subunit; | 2008 |
PUMA mediates the apoptotic signal of hypoxia/reoxygenation in cardiomyocytes through mitochondrial pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Caspase 3; Caspase 8; Cells, Cult | 2011 |
p53 is renoprotective after ischemic kidney injury by reducing inflammation.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Bone Marrow Transplantation; Chimera; Cytok | 2013 |
P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cyclin-Dependent Kinase Inhibitor p2 | 2003 |
Effects of p53 inhibitor on survival and death of cells subjected to oxidative stress.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Benzothiazoles; Brain Ischemia; Cell Death; Cell Shape; C | 2005 |
p21 and mTERT are novel markers for determining different ischemic time periods in renal ischemia-reperfusion injury.
Topics: Animals; Benzothiazoles; Biomarkers; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase | 2007 |
Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; DNA Fragmentation; Electrocardiograp | 2006 |