pifithrin has been researched along with Parkinsonian Disorders in 2 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duan, W | 1 |
| Zhu, X | 1 |
| Ladenheim, B | 1 |
| Yu, QS | 1 |
| Guo, Z | 1 |
| Oyler, J | 1 |
| Cutler, RG | 1 |
| Cadet, JL | 1 |
| Greig, NH | 1 |
| Mattson, MP | 1 |
| Liang, ZQ | 1 |
| Li, YL | 1 |
| Zhao, XL | 1 |
| Han, R | 1 |
| Wang, XX | 1 |
| Wang, Y | 1 |
| Chase, TN | 1 |
| Bennett, MC | 1 |
| Qin, ZH | 1 |
2 other studies available for pifithrin and Parkinsonian Disorders
| Article | Year |
|---|---|
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; bcl-2-Associated X Protein; Behavi | 2002 |
NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Benzothiazoles; DNA Fragmentation; Dopamine; Mal | 2007 |