pifithrin has been researched along with Neurodegenerative Diseases in 2 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gilman, CP | 1 |
| Chan, SL | 1 |
| Guo, Z | 1 |
| Zhu, X | 1 |
| Greig, N | 1 |
| Mattson, MP | 1 |
| Gudkov, AV | 1 |
| Komarova, EA | 1 |
1 review available for pifithrin and Neurodegenerative Diseases
| Article | Year |
|---|---|
Prospective therapeutic applications of p53 inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Drug Synergism; Humans; Neurodegenerative | 2005 |
1 other study available for pifithrin and Neurodegenerative Diseases
| Article | Year |
|---|---|
p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults.
Topics: Animals; Benzothiazoles; Brain; Cells, Cultured; DNA Damage; Etoposide; Membrane Potentials; Mice; M | 2003 |