pifithrin has been researched along with Neuroblastoma in 3 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Curcumin treatment activated p53 through hyperphosphorylation at serine 15 before Bex genes induction indicating Bex genes are novel downstream targets of p53." | 5.46 | Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells. ( Giri, RK; Sidhar, H, 2017) |
| "Curcumin treatment activated p53 through hyperphosphorylation at serine 15 before Bex genes induction indicating Bex genes are novel downstream targets of p53." | 1.46 | Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells. ( Giri, RK; Sidhar, H, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sidhar, H | 1 |
| Giri, RK | 1 |
| Tamagno, E | 1 |
| Parola, M | 1 |
| Guglielmotto, M | 1 |
| Santoro, G | 1 |
| Bardini, P | 1 |
| Marra, L | 1 |
| Tabaton, M | 1 |
| Danni, O | 1 |
| Nakaso, K | 1 |
| Yoshimoto, Y | 1 |
| Yano, H | 1 |
| Takeshima, T | 1 |
| Nakashima, K | 1 |
3 other studies available for pifithrin and Neuroblastoma
| Article | Year |
|---|---|
Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells.
Topics: Androstadienes; Animals; Anthracenes; Apoptosis; Benzothiazoles; Cell Line, Tumor; Curcumin; Enzyme | 2017 |
Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.
Topics: Acetylcysteine; alpha-Tocopherol; Amyloid beta-Peptides; Apoptosis; bcl-2-Associated X Protein; Benz | 2003 |
p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells.
Topics: bcl-2-Associated X Protein; Benzimidazoles; Benzothiazoles; Blotting, Western; Carbocyanines; Cell D | 2004 |