pifithrin has been researched along with Multiple Myeloma in 2 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dexamethasone is widely used in multiple myeloma (MM) for its cytotoxic effects on lymphoid cells." | 5.46 | Omega-3 Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid Enhance Dexamethasone Sensitivity in Multiple Myeloma Cells by the p53/miR-34a/Bcl-2 Axis. ( Dai, X; Geng, F; Li, M, 2017) |
| "Dexamethasone is widely used in multiple myeloma (MM) for its cytotoxic effects on lymphoid cells." | 1.46 | Omega-3 Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid Enhance Dexamethasone Sensitivity in Multiple Myeloma Cells by the p53/miR-34a/Bcl-2 Axis. ( Dai, X; Geng, F; Li, M, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, X | 1 |
| Li, M | 1 |
| Geng, F | 1 |
| Saha, MN | 1 |
| Jiang, H | 1 |
| Chang, H | 1 |
2 other studies available for pifithrin and Multiple Myeloma
| Article | Year |
|---|---|
Omega-3 Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid Enhance Dexamethasone Sensitivity in Multiple Myeloma Cells by the p53/miR-34a/Bcl-2 Axis.
Topics: 3' Untranslated Regions; Antagomirs; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Line, Tu | 2017 |
Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Cell | 2010 |