Page last updated: 2024-11-02

pifithrin and Melanoma

pifithrin has been researched along with Melanoma in 4 studies

pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"Cytotoxicity and apoptosis induced by etoposide were studied during 72 hr in human melanoma cells."7.75Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells. ( Cervinka, M; Rudolf, E; Rudolf, K, 2009)
"Temozolomide (TMZ), a DNA alkylating agent used in the treatment of melanoma, is believed to mediate its effect by addition of a methyl group to the O(6) position of guanine in DNA."7.74Temozolomide induces senescence but not apoptosis in human melanoma cells. ( Allen, J; Avery-Kiejda, KA; Hersey, P; Mhaidat, NM; Scott, RJ; Zhang, XD, 2007)
"Malignant melanoma has high metastatic potential, is highly resistant to chemotherapy, and has a poor survival rate."5.43Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis. ( Liang, L; Zhang, Z, 2016)
"Calpain-3 is an intracellular cysteine protease, belonging to Calpain superfamily and predominantly expressed in skeletal muscle."5.42Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. ( Allavena, G; Corti, A; Del Bello, B; Maellaro, E; Moretti, D; Signorini, C, 2015)
"Cytotoxicity and apoptosis induced by etoposide were studied during 72 hr in human melanoma cells."3.75Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells. ( Cervinka, M; Rudolf, E; Rudolf, K, 2009)
"Temozolomide (TMZ), a DNA alkylating agent used in the treatment of melanoma, is believed to mediate its effect by addition of a methyl group to the O(6) position of guanine in DNA."3.74Temozolomide induces senescence but not apoptosis in human melanoma cells. ( Allen, J; Avery-Kiejda, KA; Hersey, P; Mhaidat, NM; Scott, RJ; Zhang, XD, 2007)
"Malignant melanoma has high metastatic potential, is highly resistant to chemotherapy, and has a poor survival rate."1.43Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis. ( Liang, L; Zhang, Z, 2016)
"Calpain-3 is an intracellular cysteine protease, belonging to Calpain superfamily and predominantly expressed in skeletal muscle."1.42Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. ( Allavena, G; Corti, A; Del Bello, B; Maellaro, E; Moretti, D; Signorini, C, 2015)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Moretti, D1
Del Bello, B1
Allavena, G1
Corti, A1
Signorini, C1
Maellaro, E1
Liang, L1
Zhang, Z1
Rudolf, K1
Cervinka, M1
Rudolf, E1
Mhaidat, NM1
Zhang, XD1
Allen, J1
Avery-Kiejda, KA1
Scott, RJ1
Hersey, P1

Other Studies

4 other studies available for pifithrin and Melanoma

ArticleYear
Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Benzothiazoles; Calpain; Cell Death; Cell Line, Tumor; Cell Proliferation; Humans; Melanoma; Muscle

2015
Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 38, Issue:4

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Benzothiazole

2016
Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells.
    Cancer investigation, 2009, Volume: 27, Issue:7

    Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; Ataxia Telangiectasia Mutated

2009
Temozolomide induces senescence but not apoptosis in human melanoma cells.
    British journal of cancer, 2007, Nov-05, Volume: 97, Issue:9

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzothiazoles; Cell Division; Cellular Senescence; Da

2007