pifithrin has been researched along with Melanoma in 4 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cytotoxicity and apoptosis induced by etoposide were studied during 72 hr in human melanoma cells." | 7.75 | Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells. ( Cervinka, M; Rudolf, E; Rudolf, K, 2009) |
| "Temozolomide (TMZ), a DNA alkylating agent used in the treatment of melanoma, is believed to mediate its effect by addition of a methyl group to the O(6) position of guanine in DNA." | 7.74 | Temozolomide induces senescence but not apoptosis in human melanoma cells. ( Allen, J; Avery-Kiejda, KA; Hersey, P; Mhaidat, NM; Scott, RJ; Zhang, XD, 2007) |
| "Malignant melanoma has high metastatic potential, is highly resistant to chemotherapy, and has a poor survival rate." | 5.43 | Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis. ( Liang, L; Zhang, Z, 2016) |
| "Calpain-3 is an intracellular cysteine protease, belonging to Calpain superfamily and predominantly expressed in skeletal muscle." | 5.42 | Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. ( Allavena, G; Corti, A; Del Bello, B; Maellaro, E; Moretti, D; Signorini, C, 2015) |
| "Cytotoxicity and apoptosis induced by etoposide were studied during 72 hr in human melanoma cells." | 3.75 | Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells. ( Cervinka, M; Rudolf, E; Rudolf, K, 2009) |
| "Temozolomide (TMZ), a DNA alkylating agent used in the treatment of melanoma, is believed to mediate its effect by addition of a methyl group to the O(6) position of guanine in DNA." | 3.74 | Temozolomide induces senescence but not apoptosis in human melanoma cells. ( Allen, J; Avery-Kiejda, KA; Hersey, P; Mhaidat, NM; Scott, RJ; Zhang, XD, 2007) |
| "Malignant melanoma has high metastatic potential, is highly resistant to chemotherapy, and has a poor survival rate." | 1.43 | Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis. ( Liang, L; Zhang, Z, 2016) |
| "Calpain-3 is an intracellular cysteine protease, belonging to Calpain superfamily and predominantly expressed in skeletal muscle." | 1.42 | Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. ( Allavena, G; Corti, A; Del Bello, B; Maellaro, E; Moretti, D; Signorini, C, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moretti, D | 1 |
| Del Bello, B | 1 |
| Allavena, G | 1 |
| Corti, A | 1 |
| Signorini, C | 1 |
| Maellaro, E | 1 |
| Liang, L | 1 |
| Zhang, Z | 1 |
| Rudolf, K | 1 |
| Cervinka, M | 1 |
| Rudolf, E | 1 |
| Mhaidat, NM | 1 |
| Zhang, XD | 1 |
| Allen, J | 1 |
| Avery-Kiejda, KA | 1 |
| Scott, RJ | 1 |
| Hersey, P | 1 |
4 other studies available for pifithrin and Melanoma
| Article | Year |
|---|---|
Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells.
Topics: Benzothiazoles; Calpain; Cell Death; Cell Line, Tumor; Cell Proliferation; Humans; Melanoma; Muscle | 2015 |
Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Benzothiazole | 2016 |
Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells.
Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; Ataxia Telangiectasia Mutated | 2009 |
Temozolomide induces senescence but not apoptosis in human melanoma cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzothiazoles; Cell Division; Cellular Senescence; Da | 2007 |