pifithrin has been researched along with Malignant Melanoma in 4 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cytotoxicity and apoptosis induced by etoposide were studied during 72 hr in human melanoma cells." | 7.75 | Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells. ( Cervinka, M; Rudolf, E; Rudolf, K, 2009) |
| "Temozolomide (TMZ), a DNA alkylating agent used in the treatment of melanoma, is believed to mediate its effect by addition of a methyl group to the O(6) position of guanine in DNA." | 7.74 | Temozolomide induces senescence but not apoptosis in human melanoma cells. ( Allen, J; Avery-Kiejda, KA; Hersey, P; Mhaidat, NM; Scott, RJ; Zhang, XD, 2007) |
| "Malignant melanoma has high metastatic potential, is highly resistant to chemotherapy, and has a poor survival rate." | 5.43 | Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis. ( Liang, L; Zhang, Z, 2016) |
| "Calpain-3 is an intracellular cysteine protease, belonging to Calpain superfamily and predominantly expressed in skeletal muscle." | 5.42 | Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. ( Allavena, G; Corti, A; Del Bello, B; Maellaro, E; Moretti, D; Signorini, C, 2015) |
| "Cytotoxicity and apoptosis induced by etoposide were studied during 72 hr in human melanoma cells." | 3.75 | Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells. ( Cervinka, M; Rudolf, E; Rudolf, K, 2009) |
| "Temozolomide (TMZ), a DNA alkylating agent used in the treatment of melanoma, is believed to mediate its effect by addition of a methyl group to the O(6) position of guanine in DNA." | 3.74 | Temozolomide induces senescence but not apoptosis in human melanoma cells. ( Allen, J; Avery-Kiejda, KA; Hersey, P; Mhaidat, NM; Scott, RJ; Zhang, XD, 2007) |
| "Malignant melanoma has high metastatic potential, is highly resistant to chemotherapy, and has a poor survival rate." | 1.43 | Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis. ( Liang, L; Zhang, Z, 2016) |
| "Calpain-3 is an intracellular cysteine protease, belonging to Calpain superfamily and predominantly expressed in skeletal muscle." | 1.42 | Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. ( Allavena, G; Corti, A; Del Bello, B; Maellaro, E; Moretti, D; Signorini, C, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moretti, D | 1 |
| Del Bello, B | 1 |
| Allavena, G | 1 |
| Corti, A | 1 |
| Signorini, C | 1 |
| Maellaro, E | 1 |
| Liang, L | 1 |
| Zhang, Z | 1 |
| Rudolf, K | 1 |
| Cervinka, M | 1 |
| Rudolf, E | 1 |
| Mhaidat, NM | 1 |
| Zhang, XD | 1 |
| Allen, J | 1 |
| Avery-Kiejda, KA | 1 |
| Scott, RJ | 1 |
| Hersey, P | 1 |
4 other studies available for pifithrin and Malignant Melanoma
| Article | Year |
|---|---|
Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells.
Topics: Benzothiazoles; Calpain; Cell Death; Cell Line, Tumor; Cell Proliferation; Humans; Melanoma; Muscle | 2015 |
Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Benzothiazole | 2016 |
Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells.
Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; Ataxia Telangiectasia Mutated | 2009 |
Temozolomide induces senescence but not apoptosis in human melanoma cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzothiazoles; Cell Division; Cellular Senescence; Da | 2007 |