pifithrin has been researched along with Inflammation in 8 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pifithrin-µ (PFT-µ) is a drug with striking neuroprotective abilities in a preclinical model of hypoxia-ischemia (HI)-induced NE wherein cell death is a substantial cause of injury." | 1.42 | The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia. ( Chhor, V; Fleiss, B; Gressens, P; Hagberg, H; Lebon, S; Rajudin, N; Thornton, C, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, J | 1 |
| Wang, S | 1 |
| Guo, H | 1 |
| Tan, Y | 1 |
| Liang, Y | 1 |
| Feng, A | 1 |
| Liu, Q | 2 |
| Damodaran, C | 1 |
| Zhang, Z | 1 |
| Keller, BB | 1 |
| Zhang, C | 1 |
| Cai, L | 1 |
| Huang, YN | 1 |
| Yang, LY | 1 |
| Greig, NH | 1 |
| Wang, YC | 1 |
| Lai, CC | 1 |
| Wang, JY | 1 |
| Jebelli, J | 1 |
| Hooper, C | 1 |
| Pocock, JM | 1 |
| Fleiss, B | 1 |
| Chhor, V | 1 |
| Rajudin, N | 1 |
| Lebon, S | 1 |
| Hagberg, H | 1 |
| Gressens, P | 1 |
| Thornton, C | 1 |
| Murase, D | 1 |
| Hachiya, A | 1 |
| Amano, Y | 1 |
| Ohuchi, A | 1 |
| Kitahara, T | 1 |
| Takema, Y | 1 |
| Yuan, XM | 1 |
| Lei, H | 1 |
| Xia, Y | 1 |
| Ma, KH | 1 |
| Sutton, TA | 1 |
| Hato, T | 1 |
| Mai, E | 1 |
| Yoshimoto, M | 1 |
| Kuehl, S | 1 |
| Anderson, M | 1 |
| Mang, H | 1 |
| Plotkin, Z | 1 |
| Chan, RJ | 1 |
| Dagher, PC | 1 |
| Marsolais, D | 1 |
| Côté, CH | 1 |
| Frenette, J | 1 |
8 other studies available for pifithrin and Inflammation
| Article | Year |
|---|---|
Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis.
Topics: Animals; Apoptosis; Benzothiazoles; Cardiotonic Agents; Cellular Senescence; Diabetic Cardiomyopathi | 2018 |
Neuroprotective effects of pifithrin-α against traumatic brain injury in the striatum through suppression of neuroinflammation, oxidative stress, autophagy, and apoptosis.
Topics: Animals; Apoptosis; Autophagy; Benzothiazoles; Blotting, Western; Brain Injuries, Traumatic; Disease | 2018 |
Microglial p53 activation is detrimental to neuronal synapses during activation-induced inflammation: Implications for neurodegeneration.
Topics: Animals; Apoptosis; Benzothiazoles; Brain; Cells, Cultured; Inflammation; Lipopolysaccharides; Micro | 2014 |
The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia.
Topics: Animals; Benzothiazoles; Cell Line; Gene Expression; Inflammation; Mice; Microglia; Mitochondria; Ne | 2015 |
The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling.
Topics: Aging; Animals; Benzothiazoles; Cytokines; Epidermal Cells; Epidermis; Female; Gene Expression Regul | 2009 |
[Effects of hot shock protein 70 inhibitor PFTµ on inflammatory response in lipopolysaccharide-stimulated RAW264.7 cells and mice underwent myocardial ischemia-reperfusion injury].
Topics: Animals; Benzothiazoles; Cell Line; HSP70 Heat-Shock Proteins; Inflammation; Lipopolysaccharides; Ma | 2011 |
p53 is renoprotective after ischemic kidney injury by reducing inflammation.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Bone Marrow Transplantation; Chimera; Cytok | 2013 |
Pifithrin-alpha, an inhibitor of p53 transactivation, alters the inflammatory process and delays tendon healing following acute injury.
Topics: Achilles Tendon; Animals; Apoptosis; Benzothiazoles; Biomechanical Phenomena; Caspase 3; Collagen; C | 2007 |