pifithrin has been researched along with Glioma in 5 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Following treatment with casticin, cell viability, apoptosis, and cell cycle arrest were examined in U251 glioma cells." | 7.79 | Casticin induces human glioma cell death through apoptosis and mitotic arrest. ( Gu, J; He, W; Kuang, Y; Liu, E; Xing, X, 2013) |
| "Shikonin induces the generation of ROS, depletion of GSH, disruption of mitochondrial transmembrane potential, upregulation of p53, and cleavage of PARP [poly(ADP-ribose) polymerase] in U87MG glioma cells." | 7.78 | Novel multiple apoptotic mechanism of shikonin in human glioma cells. ( Chen, CH; Lin, ML; Ong, PL; Yang, JT, 2012) |
| " This was of interest because E6 silencing of p53 sensitizes U87MG astrocytic glioma cells to BCNU and temozolomide (TMZ), cytotoxic drugs that are modestly helpful in the treatment of aggressive astrocytic gliomas." | 7.73 | Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide. ( Cairncross, JG; Mymryk, JS; Xu, GW, 2005) |
| "Following treatment with casticin, cell viability, apoptosis, and cell cycle arrest were examined in U251 glioma cells." | 3.79 | Casticin induces human glioma cell death through apoptosis and mitotic arrest. ( Gu, J; He, W; Kuang, Y; Liu, E; Xing, X, 2013) |
| "Shikonin induces the generation of ROS, depletion of GSH, disruption of mitochondrial transmembrane potential, upregulation of p53, and cleavage of PARP [poly(ADP-ribose) polymerase] in U87MG glioma cells." | 3.78 | Novel multiple apoptotic mechanism of shikonin in human glioma cells. ( Chen, CH; Lin, ML; Ong, PL; Yang, JT, 2012) |
| " This was of interest because E6 silencing of p53 sensitizes U87MG astrocytic glioma cells to BCNU and temozolomide (TMZ), cytotoxic drugs that are modestly helpful in the treatment of aggressive astrocytic gliomas." | 3.73 | Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide. ( Cairncross, JG; Mymryk, JS; Xu, GW, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, E | 1 |
| Kuang, Y | 1 |
| He, W | 1 |
| Xing, X | 1 |
| Gu, J | 1 |
| Liu, YP | 1 |
| Dong, FX | 1 |
| Chai, X | 1 |
| Zhu, S | 1 |
| Zhang, BL | 1 |
| Gao, DS | 1 |
| Sinn, B | 1 |
| Schulze, J | 1 |
| Schroeder, G | 1 |
| Konschak, R | 1 |
| Freyer, D | 1 |
| Budach, V | 1 |
| Tinhofer, I | 1 |
| Chen, CH | 1 |
| Lin, ML | 1 |
| Ong, PL | 1 |
| Yang, JT | 1 |
| Xu, GW | 1 |
| Mymryk, JS | 1 |
| Cairncross, JG | 1 |
5 other studies available for pifithrin and Glioma
| Article | Year |
|---|---|
Casticin induces human glioma cell death through apoptosis and mitotic arrest.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; C | 2013 |
Role of Autophagy in Capsaicin-Induced Apoptosis in U251 Glioma Cells.
Topics: Apoptosis; Autophagy; Benzothiazoles; Capsaicin; Caspase 3; Cell Line, Tumor; Cell Survival; Glioma; | 2016 |
Pifithrin-α as a potential cytoprotective agent in radiotherapy: protection of normal tissue without decreasing therapeutic efficacy in glioma cells.
Topics: Animals; Astrocytes; Benzothiazoles; Cell Line, Tumor; Cytoprotection; Fibroblasts; G1 Phase; Gene E | 2010 |
Novel multiple apoptotic mechanism of shikonin in human glioma cells.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Benz | 2012 |
Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide.
Topics: Antineoplastic Agents, Alkylating; Benzothiazoles; Brain Neoplasms; Carmustine; Dacarbazine; DNA Dam | 2005 |