pifithrin has been researched along with Glioblastoma in 4 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we investigated the precursor and active forms of a p53 small-molecule inhibitor for their effects on temozolomide (TMZ) antitumor activity against glioblastoma (GBM), using both in vitro and in vivo experimental approaches." | 7.74 | p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. ( Berger, MS; Dinca, EB; Haas-Kogan, DA; James, CD; Lu, KV; Pieper, RO; Prados, MD; Sarkaria, JN; Vandenberg, SR, 2008) |
| "In this study, we investigated the precursor and active forms of a p53 small-molecule inhibitor for their effects on temozolomide (TMZ) antitumor activity against glioblastoma (GBM), using both in vitro and in vivo experimental approaches." | 3.74 | p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. ( Berger, MS; Dinca, EB; Haas-Kogan, DA; James, CD; Lu, KV; Pieper, RO; Prados, MD; Sarkaria, JN; Vandenberg, SR, 2008) |
| "Astrocytic tumors are the most common brain tumors with various genetic defects." | 1.35 | Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway. ( Chen, GS; Gu, Y; Li, FF; Li, H; Li, Q; Liu, F; Ye, J; Zhang, F; Zhang, LY, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Djuzenova, CS | 1 |
| Fiedler, V | 1 |
| Memmel, S | 1 |
| Katzer, A | 1 |
| Hartmann, S | 1 |
| Krohne, G | 1 |
| Zimmermann, H | 1 |
| Scholz, CJ | 1 |
| Polat, B | 1 |
| Flentje, M | 1 |
| Sukhorukov, VL | 1 |
| Lin, CJ | 1 |
| Chang, YA | 1 |
| Lin, YL | 1 |
| Liu, SH | 1 |
| Chang, CK | 1 |
| Chen, RM | 1 |
| Dinca, EB | 1 |
| Lu, KV | 1 |
| Sarkaria, JN | 1 |
| Pieper, RO | 1 |
| Prados, MD | 1 |
| Haas-Kogan, DA | 1 |
| Vandenberg, SR | 1 |
| Berger, MS | 1 |
| James, CD | 1 |
| Zhang, LY | 1 |
| Ye, J | 1 |
| Zhang, F | 1 |
| Li, FF | 1 |
| Li, H | 1 |
| Gu, Y | 1 |
| Liu, F | 1 |
| Chen, GS | 1 |
| Li, Q | 1 |
4 other studies available for pifithrin and Glioblastoma
| Article | Year |
|---|---|
Actin cytoskeleton organization, cell surface modification and invasion rate of 5 glioblastoma cell lines differing in PTEN and p53 status.
Topics: Actin Cytoskeleton; Actins; Benzothiazoles; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell M | 2015 |
Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis.
Topics: Animals; Apoptosis; Benzothiazoles; Biphenyl Compounds; Caspases; Cell Cycle Checkpoints; Cell Cycle | 2016 |
p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzothiazoles; Brain Neoplasms; Dacarbazin | 2008 |
Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Astrocytoma; Axin Protein; Benzothiazoles; Brain Neopla | 2009 |