pifithrin has been researched along with Fatty Liver in 2 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We tested the efficacy of a p53 inhibitor, pifithrin-α p-nitro (PFT) in attenuating steatosis, associated oxidative stress and apoptosis in a murine model of non-alcoholic fatty liver disease (NAFLD)." | 3.79 | Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. ( Derdak, Z; Harb, R; Sousa, A; Villegas, KA; Wands, JR; Wu, AM, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, YM | 1 |
| Lee, WK | 1 |
| Lee, YH | 1 |
| Kang, ES | 1 |
| Cha, BS | 1 |
| Lee, BW | 1 |
| Derdak, Z | 1 |
| Villegas, KA | 1 |
| Harb, R | 1 |
| Wu, AM | 1 |
| Sousa, A | 1 |
| Wands, JR | 1 |
2 other studies available for pifithrin and Fatty Liver
| Article | Year |
|---|---|
Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53.
Topics: Animals; Benzothiazoles; Caloric Restriction; Cell Survival; Diet; Endoplasmic Reticulum Stress; Fat | 2016 |
Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Apoptosis; Benzothiazoles; Cell Line; Diet, High-Fat; Disease Models, | 2013 |