pifithrin has been researched along with Disease Models, Animal in 35 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The potential salutary effect of pifithrin alpha, a novel-specific inhibitor of the transcription factor p53, administered 1-6 h following focal reversible cerebral ischemia, was investigated." | 7.72 | The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. ( Aharonowiz, M; Greig, NH; Leker, RR; Ovadia, H, 2004) |
| "3'-UTR: 3-untranslated region; CIR: cerebral ischemia-reperfusion; CIS: cerebral ischemic stroke; PFT-α: Pifithrin-α; PVDF: polyvinylidene fluoride; SD: Sprague-Dawley; TBST: tris buffered saline with tween." | 3.88 | MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53. ( Jing, L; Xie, YL; Zhang, B, 2018) |
| " We tested the efficacy of a p53 inhibitor, pifithrin-α p-nitro (PFT) in attenuating steatosis, associated oxidative stress and apoptosis in a murine model of non-alcoholic fatty liver disease (NAFLD)." | 3.79 | Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. ( Derdak, Z; Harb, R; Sousa, A; Villegas, KA; Wands, JR; Wu, AM, 2013) |
| " The potential salutary effect of pifithrin alpha, a novel-specific inhibitor of the transcription factor p53, administered 1-6 h following focal reversible cerebral ischemia, was investigated." | 3.72 | The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. ( Aharonowiz, M; Greig, NH; Leker, RR; Ovadia, H, 2004) |
| "Renal ischemia-reperfusion injury is a leading cause of acute kidney injury; the pathogenesis of which remains poorly understood and effective therapies are still lacking." | 1.46 | Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6. ( Dong, Z; Hao, J; Li, L; Mei, C; Mei, S; Su, Y; Wei, Q, 2017) |
| "Unilateral cryptorchidism was surgically induced in the rats of the cryptorchid group, PFT-α group, and cryptorchid+dissolvent of PFT-α group." | 1.40 | [Effect of PFT-α on apoptosis of spermatogenic cells caused by enorchia]. ( He, L; Long, Z; Shi, J; Xie, L; Xie, Y; Yang, Z, 2014) |
| " Half dosage of this gene in humans causes most of the features of the DiGeorge or Velocardiofacial syndrome phenotypes, including aortic arch and cardiac outflow tract abnormalities." | 1.40 | p53 Suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome. ( Baldini, A; Caprio, C, 2014) |
| "The mechanism of cerebral vasospasm following subarachnoid haemorrhage (SAH) is not understood." | 1.35 | Pifithrin-alpha reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat. ( Chen, CH; Hu, Q; Luan, LJ; Qin, LH; Shi, XZ; Yan, JH; Yang, L; Yang, XM; Zhao, J; Zhou, CM, 2008) |
| "Prion diseases, among them scrapie and BSE, are a group of fatal neurodegenerative disorders associated with the conversion of PrP(C) to PrP(Sc), its conformational abnormal isoform." | 1.33 | Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time. ( Engelstein, R; Gabizon, R; Greig, NH; Grigoriadis, N; Ovadia, H, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (34.29) | 29.6817 |
| 2010's | 21 (60.00) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Zhang, L | 1 |
| Gao, Y | 1 |
| Zhang, R | 1 |
| Sun, F | 1 |
| Cheng, C | 1 |
| Qian, F | 1 |
| Duan, X | 1 |
| Wei, G | 1 |
| Sun, C | 1 |
| Pang, X | 1 |
| Chen, P | 1 |
| Chai, R | 1 |
| Yang, T | 2 |
| Wu, H | 1 |
| Liu, D | 2 |
| Lu, T | 1 |
| Kim, PP | 1 |
| Greig, NH | 8 |
| Luo, Y | 3 |
| Jin, F | 1 |
| Wang, Y | 3 |
| Wang, X | 2 |
| Wu, Y | 1 |
| Liu, Q | 1 |
| Zhu, Y | 1 |
| Liu, E | 1 |
| Fan, J | 1 |
| Huang, YN | 2 |
| Yang, LY | 3 |
| Wang, YC | 1 |
| Lai, CC | 1 |
| Wang, JY | 3 |
| Yano, T | 1 |
| Abe, K | 1 |
| Tanno, M | 1 |
| Miki, T | 1 |
| Kuno, A | 1 |
| Miura, T | 1 |
| Steenbergen, C | 1 |
| Xie, YL | 1 |
| Zhang, B | 1 |
| Jing, L | 1 |
| Pfaff, MJ | 1 |
| Mukhopadhyay, S | 1 |
| Hoofnagle, M | 1 |
| Chabasse, C | 1 |
| Sarkar, R | 1 |
| Zhang, H | 2 |
| Xu, CF | 1 |
| Ren, C | 1 |
| Wu, TT | 1 |
| Dong, N | 1 |
| Yao, YM | 1 |
| Ehrnhoefer, DE | 1 |
| Skotte, NH | 1 |
| Ladha, S | 1 |
| Nguyen, YT | 1 |
| Qiu, X | 1 |
| Deng, Y | 1 |
| Huynh, KT | 1 |
| Engemann, S | 1 |
| Nielsen, SM | 1 |
| Becanovic, K | 1 |
| Leavitt, BR | 1 |
| Hasholt, L | 1 |
| Hayden, MR | 1 |
| Xie, L | 1 |
| He, L | 1 |
| Yang, Z | 1 |
| Shi, J | 1 |
| Long, Z | 1 |
| Xie, Y | 1 |
| Caprio, C | 1 |
| Baldini, A | 1 |
| Chu, YH | 1 |
| Tweedie, D | 2 |
| Yu, QS | 3 |
| Pick, CG | 1 |
| Hoffer, BJ | 3 |
| Zhang, P | 1 |
| Lei, X | 1 |
| Sun, Y | 1 |
| Chang, L | 1 |
| Li, C | 1 |
| Bhatta, N | 1 |
| Zhang, Z | 1 |
| Jiang, C | 1 |
| Cui, D | 1 |
| Shang, H | 1 |
| Zhang, X | 1 |
| Jiang, W | 1 |
| Jia, X | 1 |
| Hsieh, TH | 1 |
| Kao, YC | 1 |
| Hao, J | 1 |
| Wei, Q | 2 |
| Mei, S | 1 |
| Li, L | 1 |
| Su, Y | 1 |
| Mei, C | 1 |
| Dong, Z | 2 |
| Li, J | 1 |
| Ghiani, CA | 1 |
| Kim, JY | 1 |
| Liu, A | 1 |
| Sandoval, J | 1 |
| DeVellis, J | 1 |
| Casaccia-Bonnefil, P | 1 |
| Karunakaran, S | 1 |
| Saeed, U | 1 |
| Mishra, M | 1 |
| Valli, RK | 1 |
| Joshi, SD | 1 |
| Meka, DP | 1 |
| Seth, P | 1 |
| Ravindranath, V | 1 |
| Kuo, CC | 1 |
| Shen, H | 1 |
| Chou, J | 1 |
| Zhou, L | 1 |
| Fu, P | 1 |
| Huang, XR | 1 |
| Liu, F | 1 |
| Lai, KN | 1 |
| Lan, HY | 1 |
| Christodoulou, MS | 1 |
| Colombo, F | 1 |
| Passarella, D | 1 |
| Ieronimo, G | 1 |
| Zuco, V | 1 |
| De Cesare, M | 1 |
| Zunino, F | 1 |
| Xu, H | 1 |
| Menendez, S | 1 |
| Schlegelberger, B | 1 |
| Bae, N | 1 |
| Aplan, PD | 1 |
| Göhring, G | 1 |
| Deblasio, TR | 1 |
| Nimer, SD | 1 |
| Leeper, NJ | 1 |
| Raiesdana, A | 1 |
| Kojima, Y | 1 |
| Kundu, RK | 1 |
| Cheng, H | 1 |
| Maegdefessel, L | 1 |
| Toh, R | 1 |
| Ahn, GO | 1 |
| Ali, ZA | 1 |
| Anderson, DR | 1 |
| Miller, CL | 1 |
| Roberts, SC | 1 |
| Spin, JM | 1 |
| de Almeida, PE | 1 |
| Wu, JC | 1 |
| Xu, B | 1 |
| Cheng, K | 1 |
| Quertermous, M | 1 |
| Kundu, S | 1 |
| Kortekaas, KE | 1 |
| Berzin, E | 1 |
| Downing, KP | 1 |
| Dalman, RL | 1 |
| Tsao, PS | 1 |
| Schadt, EE | 1 |
| Owens, GK | 1 |
| Quertermous, T | 1 |
| Derdak, Z | 1 |
| Villegas, KA | 1 |
| Harb, R | 1 |
| Wu, AM | 1 |
| Sousa, A | 1 |
| Wands, JR | 1 |
| Sutton, TA | 1 |
| Hato, T | 1 |
| Mai, E | 1 |
| Yoshimoto, M | 1 |
| Kuehl, S | 1 |
| Anderson, M | 1 |
| Mang, H | 1 |
| Plotkin, Z | 1 |
| Chan, RJ | 1 |
| Dagher, PC | 1 |
| Leker, RR | 1 |
| Aharonowiz, M | 1 |
| Ovadia, H | 2 |
| Engelstein, R | 1 |
| Grigoriadis, N | 1 |
| Gabizon, R | 1 |
| Zhou, C | 1 |
| Yamaguchi, M | 1 |
| Colohan, AR | 1 |
| Zhang, JH | 1 |
| Strosznajder, RP | 1 |
| Jesko, H | 1 |
| Banasik, M | 1 |
| Tanaka, S | 1 |
| Eve, DJ | 1 |
| Dennis, JS | 1 |
| Citron, BA | 1 |
| Plesnila, N | 1 |
| von Baumgarten, L | 1 |
| Retiounskaia, M | 1 |
| Engel, D | 1 |
| Ardeshiri, A | 1 |
| Zimmermann, R | 1 |
| Hoffmann, F | 1 |
| Landshamer, S | 1 |
| Wagner, E | 1 |
| Culmsee, C | 2 |
| Dong, G | 1 |
| Megyesi, J | 1 |
| Price, PM | 1 |
| Yan, JH | 1 |
| Yang, XM | 1 |
| Chen, CH | 1 |
| Hu, Q | 1 |
| Zhao, J | 1 |
| Shi, XZ | 1 |
| Luan, LJ | 1 |
| Yang, L | 1 |
| Qin, LH | 1 |
| Zhou, CM | 1 |
| Zhu, X | 1 |
| Chan, SL | 1 |
| Camandola, S | 1 |
| Guo, Z | 1 |
| Mattson, MP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of New Neuroinflammation Markers in Subarachnoid Haemorrhage Patients: a Pilot Study[NCT03411746] | 60 participants (Actual) | Observational | 2018-01-26 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
35 other studies available for pifithrin and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis.
Topics: Animals; Apoptosis; Benzothiazoles; CRISPR-Associated Protein 9; Deafness; Disease Models, Animal; D | 2020 |
Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity.
Topics: Animals; bcl-2-Associated X Protein; Benzothiazoles; Central Nervous System Stimulants; Disease Mode | 2017 |
Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2-Mediated Degradation of p53.
Topics: Animals; Benzothiazoles; Bone and Bones; Bone Marrow Cells; Cell Differentiation; Cyclin-Dependent K | 2017 |
Neuroprotective effects of pifithrin-α against traumatic brain injury in the striatum through suppression of neuroinflammation, oxidative stress, autophagy, and apoptosis.
Topics: Animals; Apoptosis; Autophagy; Benzothiazoles; Blotting, Western; Brain Injuries, Traumatic; Disease | 2018 |
Does p53 Inhibition Suppress Myocardial Ischemia-Reperfusion Injury?
Topics: Animals; Benzothiazoles; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Knockout; Myocardia | 2018 |
MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Brain Infarction; Brain Ischemia; Ca | 2018 |
Tumor suppressor protein p53 negatively regulates ischemia-induced angiogenesis and arteriogenesis.
Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Benzothiazoles; Blood Flow Velocity; | 2018 |
Novel Role of p53 in Septic Immunosuppression: Involvement in Loss and Dysfunction of CD4+ T Lymphocytes.
Topics: Animals; Apoptosis; Benzothiazoles; CD4-Positive T-Lymphocytes; Disease Models, Animal; Humans; Jurk | 2018 |
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.
Topics: Animals; Benzothiazoles; Caspase 6; Cells, Cultured; Disease Models, Animal; Female; Fibroblasts; Hu | 2014 |
[Effect of PFT-α on apoptosis of spermatogenic cells caused by enorchia].
Topics: Animals; Apoptosis; Benzothiazoles; Cryptorchidism; Disease Models, Animal; Humans; Male; Rats; Rats | 2014 |
p53 Suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome.
Topics: Animals; Arteries; Benzothiazoles; Branchial Region; Chromatin; Crosses, Genetic; DiGeorge Syndrome; | 2014 |
Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.
Topics: Animals; Apoptosis; Benzothiazoles; Brain Injuries; Cell Survival; Disease Models, Animal; Male; Neu | 2015 |
Regenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner.
Topics: Animals; Benzothiazoles; Brain Ischemia; Cell Proliferation; Disease Models, Animal; In Vitro Techni | 2016 |
Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways.
Topics: Animals; Apoptosis; Autophagy; Benzothiazoles; Biomarkers; Blood Gas Analysis; Cell Death; Disease M | 2016 |
Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.
Topics: Aldehydes; Animals; Annexin A5; Apoptosis Regulatory Proteins; Benzothiazoles; Brain; Brain Injuries | 2016 |
Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Caspases; Cell Line; Disease Models, Animal | 2017 |
Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination.
Topics: Animals; Benzothiazoles; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; | 2008 |
Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Benzothiazoles; Brain; | 2008 |
Delayed treatment with a p53 inhibitor enhances recovery in stroke brain.
Topics: Adult Stem Cells; Analysis of Variance; Animals; Benzothiazoles; Brain; Bromodeoxyuridine; Cell Diff | 2009 |
Activation of p53 promotes renal injury in acute aristolochic acid nephropathy.
Topics: Animals; Apoptosis; Aristolochic Acids; Benzothiazoles; Cells, Cultured; Disease Models, Animal; Dos | 2010 |
Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors.
Topics: Animals; Antineoplastic Agents; Benzothiazoles; Cell Line, Tumor; Disease Models, Animal; Female; Ge | 2011 |
Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13-driven mouse model.
Topics: Animals; Benzothiazoles; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Flow Cytom | 2012 |
Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.
Topics: Adolescent; Adult; Aged; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Benzothia | 2013 |
Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Apoptosis; Benzothiazoles; Cell Line; Diet, High-Fat; Disease Models, | 2013 |
p53 is renoprotective after ischemic kidney injury by reducing inflammation.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Bone Marrow Transplantation; Chimera; Cytok | 2013 |
The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha.
Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Brain; Brain Ischemia; Cell Count; Disability | 2004 |
Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time.
Topics: Animals; Apoptosis; Benzothiazoles; Brain; Caspase 3; Caspases; Cell Line; Cricetinae; Disease Model | 2005 |
Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Basilar Artery; Benzothiazoles; Blotting, Western; Brain; Cerebral Angiography; | 2005 |
Effects of p53 inhibitor on survival and death of cells subjected to oxidative stress.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Benzothiazoles; Brain Ischemia; Cell Death; Cell Shape; C | 2005 |
Transcription factor p53 in degenerating spinal cords.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Behavior, Animal; Benzothiazoles; Case-Control | 2007 |
Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity.
Topics: Animals; Apoptosis; Benzothiazoles; Brain Injuries; Disease Models, Animal; Female; Humans; Male; Mi | 2007 |
Activation and involvement of p53 in cisplatin-induced nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cisplatin; Disease M | 2007 |
Pifithrin-alpha reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat.
Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Disease Models, Animal; Endothelial Cells; Ma | 2008 |
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.
Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Ca | 2001 |