pifithrin has been researched along with Cerebral Ischemia in 8 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| " The potential salutary effect of pifithrin alpha, a novel-specific inhibitor of the transcription factor p53, administered 1-6 h following focal reversible cerebral ischemia, was investigated." | 7.72 | The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. ( Aharonowiz, M; Greig, NH; Leker, RR; Ovadia, H, 2004) |
| "3'-UTR: 3-untranslated region; CIR: cerebral ischemia-reperfusion; CIS: cerebral ischemic stroke; PFT-α: Pifithrin-α; PVDF: polyvinylidene fluoride; SD: Sprague-Dawley; TBST: tris buffered saline with tween." | 3.88 | MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53. ( Jing, L; Xie, YL; Zhang, B, 2018) |
| " The potential salutary effect of pifithrin alpha, a novel-specific inhibitor of the transcription factor p53, administered 1-6 h following focal reversible cerebral ischemia, was investigated." | 3.72 | The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. ( Aharonowiz, M; Greig, NH; Leker, RR; Ovadia, H, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, YL | 1 |
| Zhang, B | 1 |
| Jing, L | 1 |
| Ahn, KC | 1 |
| MacKenzie, EM | 1 |
| Learman, CR | 1 |
| Hall, TC | 1 |
| Weaver, CL | 1 |
| Dunbar, GL | 1 |
| Song, MS | 1 |
| Zhang, P | 1 |
| Lei, X | 1 |
| Sun, Y | 1 |
| Zhang, H | 1 |
| Chang, L | 1 |
| Li, C | 1 |
| Liu, D | 1 |
| Bhatta, N | 1 |
| Zhang, Z | 1 |
| Jiang, C | 1 |
| Tu, YF | 1 |
| Lu, PJ | 1 |
| Huang, CC | 1 |
| Ho, CJ | 1 |
| Chou, YP | 1 |
| Culmsee, C | 2 |
| Siewe, J | 1 |
| Junker, V | 1 |
| Retiounskaia, M | 1 |
| Schwarz, S | 1 |
| Camandola, S | 2 |
| El-Metainy, S | 1 |
| Behnke, H | 1 |
| Mattson, MP | 2 |
| Krieglstein, J | 1 |
| Leker, RR | 1 |
| Aharonowiz, M | 1 |
| Greig, NH | 2 |
| Ovadia, H | 1 |
| Strosznajder, RP | 1 |
| Jesko, H | 1 |
| Banasik, M | 1 |
| Tanaka, S | 1 |
| Zhu, X | 1 |
| Yu, QS | 1 |
| Chan, SL | 1 |
| Guo, Z | 1 |
8 other studies available for pifithrin and Cerebral Ischemia
| Article | Year |
|---|---|
MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Brain Infarction; Brain Ischemia; Ca | 2018 |
Inhibition of p53 attenuates ischemic stress-induced activation of astrocytes.
Topics: Animals; Astrocytes; Benzothiazoles; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Central Nervous | 2015 |
Regenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner.
Topics: Animals; Benzothiazoles; Brain Ischemia; Cell Proliferation; Disease Models, Animal; In Vitro Techni | 2016 |
Moderate dietary restriction reduces p53-mediated neurovascular damage and microglia activation after hypoxic ischemia in neonatal brain.
Topics: Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Blood-Brain Barrier; Blotting, Western; Body W | 2012 |
Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.
Topics: Acetyltransferases; Animals; Benzothiazoles; Brain Ischemia; Cell Cycle Proteins; Cell Death; Cell H | 2003 |
The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha.
Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Brain; Brain Ischemia; Cell Count; Disability | 2004 |
Effects of p53 inhibitor on survival and death of cells subjected to oxidative stress.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Benzothiazoles; Brain Ischemia; Cell Death; Cell Shape; C | 2005 |
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.
Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Ca | 2001 |