pifithrin has been researched along with Cancer of Prostate in 5 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Androgen-independent prostate cancer cells are remarkably resistant to therapeutic agents that work by triggering apoptosis via the caspase cascade." | 2.41 | Resistance to apoptosis in prostate cancer cells. ( Howell, SB, 2000) |
| "Exposure of human prostate cancer 22Rv1 cells, harboring wild-type p53, to growth-suppressive concentrations (10-80 microM) of apigenin resulted in the stabilization of p53 by phosphorylation on critical serine sites, p14ARF-mediated downregulation of MDM2 protein, inhibition of NF-kappaB/p65 transcriptional activity, and induction of p21/WAF-1 in a dose- and time-dependent manner." | 1.35 | Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. ( Gupta, S; Shukla, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Misra, UK | 1 |
| Pizzo, SV | 1 |
| Jiang, C | 1 |
| Hu, H | 1 |
| Malewicz, B | 1 |
| Wang, Z | 1 |
| Lü, J | 1 |
| Nazarova, N | 1 |
| Qiao, S | 1 |
| Golovko, O | 1 |
| Lou, YR | 1 |
| Tuohimaa, P | 1 |
| Shukla, S | 1 |
| Gupta, S | 1 |
| Howell, SB | 1 |
1 review available for pifithrin and Cancer of Prostate
| Article | Year |
|---|---|
Resistance to apoptosis in prostate cancer cells.
Topics: Androgen Antagonists; Androgens; Apoptosis; Benzothiazoles; Caspases; DNA Repair; Drug Resistance, N | 2000 |
4 other studies available for pifithrin and Cancer of Prostate
| Article | Year |
|---|---|
PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells.
Topics: Antibodies, Neoplasm; Apoptosis; Apoptosis Regulatory Proteins; Autoantibodies; Benzothiazoles; Casp | 2010 |
Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Benzothiazoles; Caspase Inhibitors; Caspases; Cell Line, | 2004 |
Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth.
Topics: Antineoplastic Agents; Benzothiazoles; Bone Morphogenetic Proteins; Calcitriol; Calcium Channel Agon | 2004 |
Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apigenin; Apoptosis; Benzothiazoles | 2008 |