pifithrin has been researched along with Breast Neoplasms in 10 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The impairment of SNO homeostasis in breast cancer cells was achieved with the highly specific TrxR inhibitor auranofin and/or exposure to S-nitroso-L-cysteine." | 3.78 | Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors. ( Aranda, E; Cañas, A; De La Haba-Rodríguez, JR; Fuentes, E; Hernández, V; López-Pedrera, C; López-Sánchez, LM; Muñoz-Castañeda, JR; Rodríguez-Ariza, A; Valverde-Estepa, A, 2012) |
| "Breast cancer is currently the leading cause of cancer-related deaths among women globally." | 1.39 | The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways. ( Hsu, A; Tan, BK; Wong, FC; Woo, CC, 2013) |
| "Together these findings suggest that in breast cancer cells, p53 promotes theaflavin-induced apoptosis in a transcription-dependent manner through mitochondrial death cascade." | 1.35 | Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. ( Banerjee, S; Bhattacharyya, A; Bhattacharyya, S; Chakraborty, J; Chattopadhyay, S; Choudhuri, T; Das, T; Lahiry, L; Mandal, D; Sa, G; Saha, B, 2008) |
| "2." | 1.31 | Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells. ( Chopin, V; Jouy, N; Le Bourhis, X; Toillon, RA, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wong, FC | 1 |
| Woo, CC | 1 |
| Hsu, A | 1 |
| Tan, BK | 1 |
| Ireno, IC | 1 |
| Wiehe, RS | 1 |
| Stahl, AI | 1 |
| Hampp, S | 1 |
| Aydin, S | 1 |
| Troester, MA | 1 |
| Selivanova, G | 1 |
| Wiesmüller, L | 1 |
| Struckhoff, AP | 1 |
| Patel, B | 1 |
| Beckman, BS | 1 |
| Kim, S | 1 |
| Han, J | 1 |
| Lee, SK | 1 |
| Hur, SM | 1 |
| Koo, M | 1 |
| Cho, DH | 1 |
| Bae, SY | 1 |
| Choi, MY | 1 |
| Shin, I | 1 |
| Yang, JH | 1 |
| Nam, SJ | 1 |
| Lee, JE | 1 |
| Nakari, M | 1 |
| Kanouchi, H | 1 |
| Oka, T | 1 |
| Cañas, A | 1 |
| López-Sánchez, LM | 1 |
| Valverde-Estepa, A | 1 |
| Hernández, V | 1 |
| Fuentes, E | 1 |
| Muñoz-Castañeda, JR | 1 |
| López-Pedrera, C | 1 |
| De La Haba-Rodríguez, JR | 1 |
| Aranda, E | 1 |
| Rodríguez-Ariza, A | 1 |
| Plísková, M | 1 |
| Vondrácek, J | 1 |
| Vojtesek, B | 1 |
| Kozubík, A | 1 |
| Machala, M | 1 |
| Sparfel, L | 1 |
| Van Grevenynghe, J | 1 |
| Le Vee, M | 1 |
| Aninat, C | 1 |
| Fardel, O | 1 |
| Lahiry, L | 1 |
| Saha, B | 1 |
| Chakraborty, J | 1 |
| Bhattacharyya, S | 1 |
| Chattopadhyay, S | 1 |
| Banerjee, S | 1 |
| Choudhuri, T | 1 |
| Mandal, D | 1 |
| Bhattacharyya, A | 1 |
| Sa, G | 1 |
| Das, T | 1 |
| Chopin, V | 1 |
| Toillon, RA | 1 |
| Jouy, N | 1 |
| Le Bourhis, X | 1 |
10 other studies available for pifithrin and Breast Neoplasms
| Article | Year |
|---|---|
The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways.
Topics: Antineoplastic Agents; Apoptosis; Benzothiazoles; Breast Neoplasms; Caspases; Cell Cycle; Humans; MC | 2013 |
Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53.
Topics: Benzothiazoles; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Female; Gene Knockdown Techni | 2014 |
Inhibition of p53 sensitizes MCF-7 cells to ceramide treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzothiazoles; Breast Neoplasms; Carcino | 2010 |
Pifithrin-α, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway.
Topics: Benzothiazoles; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Cyclooxygenase 2; Dose-Response | 2010 |
High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α.
Topics: Acetonitriles; Antineoplastic Agents; Apoptosis; Benzothiazoles; Breast Neoplasms; Cell Line, Tumor; | 2011 |
Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors.
Topics: Antineoplastic Agents, Hormonal; Antirheumatic Agents; Auranofin; Benzothiazoles; Breast Neoplasms; | 2012 |
Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events.
Topics: Benz(a)Anthracenes; Benzo(a)pyrene; Benzothiazoles; Breast Neoplasms; Bromodeoxyuridine; Carcinogens | 2005 |
Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha.
Topics: Apoptosis; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzothiazoles; Breast Neoplasms; Carcinog | 2006 |
Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis.
Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Biflavonoids; Breast Neoplasms; Caspases; Cat | 2008 |
Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Blotting, Western; Breast Neoplasms; Butyrate | 2002 |