pifithrin has been researched along with Brain Neoplasms in 4 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we investigated the precursor and active forms of a p53 small-molecule inhibitor for their effects on temozolomide (TMZ) antitumor activity against glioblastoma (GBM), using both in vitro and in vivo experimental approaches." | 7.74 | p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. ( Berger, MS; Dinca, EB; Haas-Kogan, DA; James, CD; Lu, KV; Pieper, RO; Prados, MD; Sarkaria, JN; Vandenberg, SR, 2008) |
| " This was of interest because E6 silencing of p53 sensitizes U87MG astrocytic glioma cells to BCNU and temozolomide (TMZ), cytotoxic drugs that are modestly helpful in the treatment of aggressive astrocytic gliomas." | 7.73 | Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide. ( Cairncross, JG; Mymryk, JS; Xu, GW, 2005) |
| "In this study, we investigated the precursor and active forms of a p53 small-molecule inhibitor for their effects on temozolomide (TMZ) antitumor activity against glioblastoma (GBM), using both in vitro and in vivo experimental approaches." | 3.74 | p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. ( Berger, MS; Dinca, EB; Haas-Kogan, DA; James, CD; Lu, KV; Pieper, RO; Prados, MD; Sarkaria, JN; Vandenberg, SR, 2008) |
| " This was of interest because E6 silencing of p53 sensitizes U87MG astrocytic glioma cells to BCNU and temozolomide (TMZ), cytotoxic drugs that are modestly helpful in the treatment of aggressive astrocytic gliomas." | 3.73 | Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide. ( Cairncross, JG; Mymryk, JS; Xu, GW, 2005) |
| "Astrocytic tumors are the most common brain tumors with various genetic defects." | 1.35 | Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway. ( Chen, GS; Gu, Y; Li, FF; Li, H; Li, Q; Liu, F; Ye, J; Zhang, F; Zhang, LY, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Djuzenova, CS | 1 |
| Fiedler, V | 1 |
| Memmel, S | 1 |
| Katzer, A | 1 |
| Hartmann, S | 1 |
| Krohne, G | 1 |
| Zimmermann, H | 1 |
| Scholz, CJ | 1 |
| Polat, B | 1 |
| Flentje, M | 1 |
| Sukhorukov, VL | 1 |
| Dinca, EB | 1 |
| Lu, KV | 1 |
| Sarkaria, JN | 1 |
| Pieper, RO | 1 |
| Prados, MD | 1 |
| Haas-Kogan, DA | 1 |
| Vandenberg, SR | 1 |
| Berger, MS | 1 |
| James, CD | 1 |
| Zhang, LY | 1 |
| Ye, J | 1 |
| Zhang, F | 1 |
| Li, FF | 1 |
| Li, H | 1 |
| Gu, Y | 1 |
| Liu, F | 1 |
| Chen, GS | 1 |
| Li, Q | 1 |
| Xu, GW | 1 |
| Mymryk, JS | 1 |
| Cairncross, JG | 1 |
4 other studies available for pifithrin and Brain Neoplasms
| Article | Year |
|---|---|
Actin cytoskeleton organization, cell surface modification and invasion rate of 5 glioblastoma cell lines differing in PTEN and p53 status.
Topics: Actin Cytoskeleton; Actins; Benzothiazoles; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell M | 2015 |
p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzothiazoles; Brain Neoplasms; Dacarbazin | 2008 |
Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Astrocytoma; Axin Protein; Benzothiazoles; Brain Neopla | 2009 |
Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide.
Topics: Antineoplastic Agents, Alkylating; Benzothiazoles; Brain Neoplasms; Carmustine; Dacarbazine; DNA Dam | 2005 |