pifithrin has been researched along with Brain Ischemia in 8 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The potential salutary effect of pifithrin alpha, a novel-specific inhibitor of the transcription factor p53, administered 1-6 h following focal reversible cerebral ischemia, was investigated." | 7.72 | The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. ( Aharonowiz, M; Greig, NH; Leker, RR; Ovadia, H, 2004) |
| "3'-UTR: 3-untranslated region; CIR: cerebral ischemia-reperfusion; CIS: cerebral ischemic stroke; PFT-α: Pifithrin-α; PVDF: polyvinylidene fluoride; SD: Sprague-Dawley; TBST: tris buffered saline with tween." | 3.88 | MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53. ( Jing, L; Xie, YL; Zhang, B, 2018) |
| " The potential salutary effect of pifithrin alpha, a novel-specific inhibitor of the transcription factor p53, administered 1-6 h following focal reversible cerebral ischemia, was investigated." | 3.72 | The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. ( Aharonowiz, M; Greig, NH; Leker, RR; Ovadia, H, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, YL | 1 |
| Zhang, B | 1 |
| Jing, L | 1 |
| Ahn, KC | 1 |
| MacKenzie, EM | 1 |
| Learman, CR | 1 |
| Hall, TC | 1 |
| Weaver, CL | 1 |
| Dunbar, GL | 1 |
| Song, MS | 1 |
| Zhang, P | 1 |
| Lei, X | 1 |
| Sun, Y | 1 |
| Zhang, H | 1 |
| Chang, L | 1 |
| Li, C | 1 |
| Liu, D | 1 |
| Bhatta, N | 1 |
| Zhang, Z | 1 |
| Jiang, C | 1 |
| Tu, YF | 1 |
| Lu, PJ | 1 |
| Huang, CC | 1 |
| Ho, CJ | 1 |
| Chou, YP | 1 |
| Culmsee, C | 2 |
| Siewe, J | 1 |
| Junker, V | 1 |
| Retiounskaia, M | 1 |
| Schwarz, S | 1 |
| Camandola, S | 2 |
| El-Metainy, S | 1 |
| Behnke, H | 1 |
| Mattson, MP | 2 |
| Krieglstein, J | 1 |
| Leker, RR | 1 |
| Aharonowiz, M | 1 |
| Greig, NH | 2 |
| Ovadia, H | 1 |
| Strosznajder, RP | 1 |
| Jesko, H | 1 |
| Banasik, M | 1 |
| Tanaka, S | 1 |
| Zhu, X | 1 |
| Yu, QS | 1 |
| Chan, SL | 1 |
| Guo, Z | 1 |
8 other studies available for pifithrin and Brain Ischemia
| Article | Year |
|---|---|
MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Brain Infarction; Brain Ischemia; Ca | 2018 |
Inhibition of p53 attenuates ischemic stress-induced activation of astrocytes.
Topics: Animals; Astrocytes; Benzothiazoles; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Central Nervous | 2015 |
Regenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner.
Topics: Animals; Benzothiazoles; Brain Ischemia; Cell Proliferation; Disease Models, Animal; In Vitro Techni | 2016 |
Moderate dietary restriction reduces p53-mediated neurovascular damage and microglia activation after hypoxic ischemia in neonatal brain.
Topics: Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Blood-Brain Barrier; Blotting, Western; Body W | 2012 |
Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.
Topics: Acetyltransferases; Animals; Benzothiazoles; Brain Ischemia; Cell Cycle Proteins; Cell Death; Cell H | 2003 |
The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha.
Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Brain; Brain Ischemia; Cell Count; Disability | 2004 |
Effects of p53 inhibitor on survival and death of cells subjected to oxidative stress.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Benzothiazoles; Brain Ischemia; Cell Death; Cell Shape; C | 2005 |
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.
Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Ca | 2001 |