pifithrin has been researched along with Brain Injuries in 4 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rachmany, L | 1 |
| Tweedie, D | 2 |
| Rubovitch, V | 1 |
| Yu, QS | 2 |
| Li, Y | 1 |
| Wang, JY | 2 |
| Pick, CG | 2 |
| Greig, NH | 2 |
| Dong, Y | 1 |
| Ito, T | 1 |
| Velayo, C | 1 |
| Sato, T | 1 |
| Iida, K | 1 |
| Endo, M | 1 |
| Funamoto, K | 1 |
| Sato, N | 1 |
| Yaegashi, N | 1 |
| Kimura, Y | 1 |
| Yang, LY | 1 |
| Chu, YH | 1 |
| Hoffer, BJ | 1 |
| Plesnila, N | 1 |
| von Baumgarten, L | 1 |
| Retiounskaia, M | 1 |
| Engel, D | 1 |
| Ardeshiri, A | 1 |
| Zimmermann, R | 1 |
| Hoffmann, F | 1 |
| Landshamer, S | 1 |
| Wagner, E | 1 |
| Culmsee, C | 1 |
4 other studies available for pifithrin and Brain Injuries
| Article | Year |
|---|---|
Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-α.
Topics: Animals; Benzothiazoles; Brain Injuries; Cell Death; Cell Line; Cell Survival; Cognitive Dysfunction | 2013 |
Intrauterine ischemic reperfusion switches the fetal transcriptional pattern from HIF-1α- to P53-dependent regulation in the murine brain.
Topics: Animals; Benzothiazoles; Brain Injuries; Female; Fetus; Gene Expression Regulation; Hypoxia-Inducibl | 2014 |
Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.
Topics: Animals; Apoptosis; Benzothiazoles; Brain Injuries; Cell Survival; Disease Models, Animal; Male; Neu | 2015 |
Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity.
Topics: Animals; Apoptosis; Benzothiazoles; Brain Injuries; Disease Models, Animal; Female; Humans; Male; Mi | 2007 |