pifithrin has been researched along with Brain Infarction in 2 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Brain Infarction: Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3'-UTR: 3-untranslated region; CIR: cerebral ischemia-reperfusion; CIS: cerebral ischemic stroke; PFT-α: Pifithrin-α; PVDF: polyvinylidene fluoride; SD: Sprague-Dawley; TBST: tris buffered saline with tween." | 3.88 | MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53. ( Jing, L; Xie, YL; Zhang, B, 2018) |
| "PFT-α inhibited neurological deficits, brain infarct volume, neuroinflammation, apoptosis, and BBB integrity than the MCAO/R rats; however, this inhibition was reversed by DKK1." | 1.91 | PFT-α protects the blood-brain barrier through the Wnt/β-catenin pathway after acute ischemic stroke. ( Du, D; Gao, X; Li, Z; Liu, P; Tian, X; Wang, B; Xu, Y; Yang, S; Zhang, H, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Du, D | 1 |
| Gao, X | 1 |
| Tian, X | 1 |
| Xu, Y | 1 |
| Wang, B | 1 |
| Yang, S | 1 |
| Liu, P | 1 |
| Li, Z | 1 |
| Xie, YL | 1 |
| Zhang, B | 1 |
| Jing, L | 1 |
2 other studies available for pifithrin and Brain Infarction
| Article | Year |
|---|---|
PFT-α protects the blood-brain barrier through the Wnt/β-catenin pathway after acute ischemic stroke.
Topics: Animals; beta Catenin; Blood-Brain Barrier; Brain Infarction; Endothelial Cells; Fluorescein; Ischem | 2023 |
MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Brain Infarction; Brain Ischemia; Ca | 2018 |