pifithrin has been researched along with Benign Neoplasms in 8 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "When the cancer cells were cocultured with the CAF aggregates incorporating GM-PFT, the invasion rate of cancer cells was significantly high compared with CAF aggregates or CAF aggregates incorporating GM with or without the same dose of free PFT as well as two-dimension cultured CAF with or without the same dose of PFT." | 1.51 | A Cancer Invasion Model Combined with Cancer-Associated Fibroblasts Aggregates Incorporating Gelatin Hydrogel Microspheres Containing a p53 Inhibitor. ( Makino, K; Nii, T; Tabata, Y, 2019) |
| "We found that ADR treatment of cancer cells in HG increased autophagy, as displayed by greater LC3II accumulation and p62 degradation compared to ADR-treated cells in low glucose." | 1.46 | p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions. ( Baldari, S; Cirone, M; D'Orazi, G; Garufi, A; Pistritto, G; Toietta, G, 2017) |
| "Chemotherapy and radiation therapy for cancer often have severe side effects that limit their efficacy." | 1.30 | A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. ( Chernov, MV; Christov-Tselkov, K; Coon, JS; Gudkov, AV; Komarov, PG; Komarova, EA; Kondratov, RV, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nii, T | 1 |
| Makino, K | 1 |
| Tabata, Y | 1 |
| Garufi, A | 1 |
| Pistritto, G | 1 |
| Baldari, S | 1 |
| Toietta, G | 1 |
| Cirone, M | 1 |
| D'Orazi, G | 1 |
| Yang, A | 1 |
| Liu, F | 1 |
| Guan, B | 1 |
| Luo, Z | 1 |
| Lin, J | 1 |
| Fang, W | 1 |
| Liu, L | 1 |
| Zuo, W | 1 |
| Leonova, KI | 1 |
| Shneyder, J | 1 |
| Antoch, MP | 1 |
| Toshkov, IA | 1 |
| Novototskaya, LR | 1 |
| Komarov, PG | 2 |
| Komarova, EA | 4 |
| Gudkov, AV | 4 |
| Kondratov, RV | 1 |
| Christov-Tselkov, K | 1 |
| Coon, JS | 1 |
| Chernov, MV | 1 |
| Ferber, D | 1 |
2 reviews available for pifithrin and Benign Neoplasms
| Article | Year |
|---|---|
Dangerous habits of a security guard: the two faces of p53 as a drug target.
Topics: Animals; Apoptosis; Benzothiazoles; Gene Expression Regulation; Genes, p53; Humans; Neoplasms; Tolue | 2007 |
Suppression of p53: a new approach to overcome side effects of antitumor therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Gene Expression Regulation, Neoplastic; G | 2000 |
6 other studies available for pifithrin and Benign Neoplasms
| Article | Year |
|---|---|
A Cancer Invasion Model Combined with Cancer-Associated Fibroblasts Aggregates Incorporating Gelatin Hydrogel Microspheres Containing a p53 Inhibitor.
Topics: Benzothiazoles; Cancer-Associated Fibroblasts; Cell Line, Tumor; Gelatin; Humans; Hydrogels; Microsp | 2019 |
p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Benzothia | 2017 |
p53 induces miR-199a-3p to suppress mechanistic target of rapamycin activation in cisplatin-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Cell Proliferation; Cisplatin; Drug Resista | 2019 |
A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice.
Topics: Animals; Benzothiazoles; Cell Proliferation; Cells, Cultured; Gamma Rays; Hematopoietic Stem Cells; | 2010 |
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Division; Cell Line; Cell Nucleus; C | 1999 |
Cancer research. A new way to combat therapy side effects.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Division; Cells, Cultured; Drug Eval | 1999 |