pifithrin has been researched along with Amyotrophic Lateral Sclerosis in 2 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dexpramipexole is a BTZ structural analog of riluzole and was a great hope for the treatment of ALS." | 6.66 | From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies. ( Desaphy, JF; Lentini, G; Majoral, JP; Mignani, S, 2020) |
| "Dexpramipexole is a BTZ structural analog of riluzole and was a great hope for the treatment of ALS." | 2.66 | From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies. ( Desaphy, JF; Lentini, G; Majoral, JP; Mignani, S, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mignani, S | 1 |
| Majoral, JP | 1 |
| Desaphy, JF | 1 |
| Lentini, G | 1 |
| Eve, DJ | 1 |
| Dennis, JS | 1 |
| Citron, BA | 1 |
1 review available for pifithrin and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies.
Topics: Amyotrophic Lateral Sclerosis; Animals; Benzothiazoles; Clinical Trials as Topic; Drug Approval; Dru | 2020 |
1 other study available for pifithrin and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Transcription factor p53 in degenerating spinal cords.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Behavior, Animal; Benzothiazoles; Case-Control | 2007 |