pifithrin has been researched along with Acute Kidney Injury in 11 studies
pifithrin: a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 ml/kg saline (Group A) or of the same volume 50% glycerol was used to induce rhabdomyolysis and subsequent AKI (Group B)." | 8.12 | Pifithrin-α ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation. ( Jiejun, W; Lisha, Z; Niansong, W; Qin, X; Yuqiang, C, 2022) |
| " In this study, we evaluated the role of p53 activation in glycerol-induced acute kidney injury (Gly-AKI)." | 7.77 | p53-Mediated oxidative stress and tubular injury in rats with glycerol-induced acute kidney injury. ( Bouçada Inácio Peixoto, E; Butori Lopes de Faria, J; Homsi, E; Janino, P; Machado de Brito, S; Mota da Silva, S, 2011) |
| "5 ml/kg saline (Group A) or of the same volume 50% glycerol was used to induce rhabdomyolysis and subsequent AKI (Group B)." | 4.12 | Pifithrin-α ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation. ( Jiejun, W; Lisha, Z; Niansong, W; Qin, X; Yuqiang, C, 2022) |
| " Here, we tested whether the inhibition of p53 may ameliorate vancomycin (VAN) induced acute kidney injury (AKI)." | 3.83 | p53 activates miR-192-5p to mediate vancomycin induced AKI. ( Chen, J; Li, H; Wang, J; Wang, S; Xiang, X; Zhang, D, 2016) |
| " In this study, we evaluated the role of p53 activation in glycerol-induced acute kidney injury (Gly-AKI)." | 3.77 | p53-Mediated oxidative stress and tubular injury in rats with glycerol-induced acute kidney injury. ( Bouçada Inácio Peixoto, E; Butori Lopes de Faria, J; Homsi, E; Janino, P; Machado de Brito, S; Mota da Silva, S, 2011) |
| "Renal ischemia-reperfusion injury is a leading cause of acute kidney injury; the pathogenesis of which remains poorly understood and effective therapies are still lacking." | 1.46 | Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6. ( Dong, Z; Hao, J; Li, L; Mei, C; Mei, S; Su, Y; Wei, Q, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Yuqiang, C | 1 |
| Lisha, Z | 1 |
| Jiejun, W | 1 |
| Qin, X | 1 |
| Niansong, W | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Yang, A | 1 |
| Liu, F | 1 |
| Guan, B | 1 |
| Luo, Z | 1 |
| Lin, J | 1 |
| Fang, W | 1 |
| Liu, L | 1 |
| Zuo, W | 1 |
| Hao, J | 1 |
| Wei, Q | 2 |
| Mei, S | 1 |
| Li, L | 1 |
| Su, Y | 1 |
| Mei, C | 1 |
| Dong, Z | 2 |
| Chen, J | 1 |
| Wang, J | 1 |
| Li, H | 1 |
| Wang, S | 1 |
| Xiang, X | 1 |
| Zhang, D | 1 |
| Sutton, TA | 3 |
| Wilkinson, J | 1 |
| Mang, HE | 2 |
| Knipe, NL | 2 |
| Plotkin, Z | 3 |
| Hosein, M | 1 |
| Zak, K | 1 |
| Wittenborn, J | 1 |
| Dagher, PC | 3 |
| Homsi, E | 1 |
| Mota da Silva, S | 1 |
| Machado de Brito, S | 1 |
| Bouçada Inácio Peixoto, E | 1 |
| Butori Lopes de Faria, J | 1 |
| Janino, P | 1 |
| Shimizu, H | 1 |
| Bolati, D | 1 |
| Adijiang, A | 1 |
| Muteliefu, G | 1 |
| Enomoto, A | 1 |
| Nishijima, F | 1 |
| Dateki, M | 1 |
| Niwa, T | 1 |
| Mai, EM | 1 |
| Hato, T | 2 |
| Lee, SY | 1 |
| Anderson, MD | 1 |
| Karozos, SC | 1 |
| Mai, E | 1 |
| Yoshimoto, M | 1 |
| Kuehl, S | 1 |
| Anderson, M | 1 |
| Mang, H | 1 |
| Chan, RJ | 1 |
| Dong, G | 1 |
| Yang, T | 1 |
| Megyesi, J | 1 |
| Price, PM | 1 |
11 other studies available for pifithrin and Acute Kidney Injury
| Article | Year |
|---|---|
Pifithrin-α ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation.
Topics: Acute Kidney Injury; Animals; Benzothiazoles; Glycerol; Mice; Mice, Inbred C57BL; Rhabdomyolysis; To | 2022 |
Acute kidney injury induces dramatic p21 upregulation via a novel, glucocorticoid-activated, pathway.
Topics: Acute Kidney Injury; Animals; Benzothiazoles; Cyclin-Dependent Kinase Inhibitor p21; Dexamethasone; | 2019 |
p53 induces miR-199a-3p to suppress mechanistic target of rapamycin activation in cisplatin-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Cell Proliferation; Cisplatin; Drug Resista | 2019 |
Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Caspases; Cell Line; Disease Models, Animal | 2017 |
p53 activates miR-192-5p to mediate vancomycin induced AKI.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Blood Urea Nitrogen; Cell Cycle; Cell Line; | 2016 |
p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Benzothiazoles; Cell Line; Hypoxia-Inducible Factor 1, alpha Subunit; | 2008 |
p53-Mediated oxidative stress and tubular injury in rats with glycerol-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Caspase 3; Glycerol; In Situ Nick-End Label | 2011 |
NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells.
Topics: Actins; Acute Kidney Injury; Animals; Benzothiazoles; beta-Galactosidase; Cell Line; Cell Proliferat | 2011 |
The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury.
Topics: Acute Kidney Injury; Animals; Benzothiazoles; Fibrosis; Ischemia; Kidney; Male; Rats; Rats, Sprague- | 2012 |
p53 is renoprotective after ischemic kidney injury by reducing inflammation.
Topics: Acute Kidney Injury; Animals; Apoptosis; Benzothiazoles; Bone Marrow Transplantation; Chimera; Cytok | 2013 |
Activation and involvement of p53 in cisplatin-induced nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cisplatin; Disease M | 2007 |