Page last updated: 2024-08-23

picrotoxin and Seizures

picrotoxin has been researched along with Seizures in 475 studies

Research

Studies (475)

TimeframeStudies, this research(%)All Research%
pre-1990208 (43.79)18.7374
1990's112 (23.58)18.2507
2000's95 (20.00)29.6817
2010's45 (9.47)24.3611
2020's15 (3.16)2.80

Authors

AuthorsStudies
Fatima, A; Maqbool, S; Sadaf, R; Younus, I1
Distler, U; Ihbe, N; Kürten, T; Mittmann, T; Sielaff, M; Tenzer, S; Ueberbach, T1
Mishchenko, M; Shtrygol, D; Shtrygol, S; Tsyvunin, V1
Adeyemi, OO; Afolayan, O; Ajayi, AM; Ben-Azu, B; Ishola, IO; James, AB; Nwose, E; Olubodun-Obadun, TG; Umukoro, S1
Georgiyants, V; Kayal, WE; Mishchenko, M; Severina, H; Shtrygol, D; Shtrygol, S; Zalevskyi, S1
Adassi, MB; Foutsop, AF; Kom, TD; Ngo Bum, E; Ngoupaye, GT; Yassi, FB1
Bao, X; Cai, J; Han, QT; Li, F; Qu, J; Shi, Q; Wang, XL; Yang, WQ; Yu, SS; Zang, C; Zhang, CJ; Zhang, D; Zhou, L1
Deyama, S; Ito, S; Izumi, S; Kaneda, K; Niitani, K; Nishitani, N; Wada, S1
Bandara, SB; Carty, DR; Harvey, DJ; Lein, PJ; Pressly, B; Singh, V; Vasylieva, N; Wulff, H1
Adeyeba, OA; Awosan, OB; Ayankunle, AA; Kolawole, OT; Onaolapo, OJ; Wakeel, OK1
Ahamad, T; Dhawale, K; Gawande, MB; Ghorai, SK; Nilkanth, PR; Sathiyanarayanan, A; Shelke, SN1
Chen, HY; Chen, YC; Huang, LC; Yu, JH1
Carmona-Aparicio, L; González-Trujano, ME; Martínez-Vargas, D; Santos-Valencia, F; Urbina-Trejo, E; Villasana-Salazar, B1
Garcia, V; Voss, LJ1
Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD1
Barker, S; Costa, ACS; Faber, J; Pinheiro, DJLL; Scorza, CA; Scott-McKean, JJ; Stasko, MR; Victorino, DB1
Carandini, M; Kullmann, DM; Rossi, LF; Wykes, RC1
He, Z; Li, D; Li, P; Li, Y; Liang, L; Luo, X; Ma, J; Qin, L; Sun, Y; Zhou, X1
da Rosa, MS; Gonçalves, D; Leipnitz, G; Luft, JG; Morás, AM; Moura, DJ; Pereira, P; Pflüger, PF; Regner, GG; Steffens, L1
Distler, MG; Escayg, A; Gorfinkle, N; Palmer, AA; Papale, LA; Termini, J; Winawer, MR; Wuenschell, GE1
Imoto, K; Ishihara, H; Kaneko, K; Kase, D; Nairn, AC; Obata, K; Yamagata, Y1
Dhir, A; Rogawski, MA; Zolkowska, D1
Aguiar, CC; Almeida, AB; Araújo, PV; Chaves, EM; de Barros Viana, GS; do Vale, OC; Leal, LK; Macêdo, DS; Vasconcelos, GS; Vasconcelos, SM1
Aykan, DA; Erkoseoglu, I; Kadioglu, M; Kalyoncu, NI; Kesim, M; Yaris, E; Yulug, E1
Ahangar, N; Ebrahimzadeh, MA; Nabavi, SF; Nabavi, SM1
Bennett, CF; Chen, G; Cirrito, JR; DeVos, SL; Goncharoff, DK; Holtzman, DM; Kebodeaux, CS; Maloney, SE; Miller, TM; Rigo, F; Schuler, DR; Stewart, FR; Wozniak, DF; Yamada, K1
Chow, E; Gane, J; Jeffrey, M; Lang, M; Wu, C; Zhang, L1
Alhumayyd, MS; Bukhari, IA; Gilani, AH; Mahesar, AL; Pivac, N1
Abdel Razzak, RL; Alzoubi, KH; Hasan, ZA1
Ananthalakshmi, KV; Edafiogho, IO; Kombian, SB; Phillips, OA; Qaddoumi, MG1
Chang, CF; Chen, CS; Chuang, TH; Mukkanti, K; Pusuluri, S; Sorra, K; Wu, CR1
Abramov, DA; Kapitsa, IG; Kaplun, AP; Prokhorov, DI; Sariev, AK; Seifulla, RD; Shiriaeva, MV; Voronina, TA; Zhuravko, AS1
Al-Obaid, AM; Al-Salem, HS; El-Messery, SM; El-Subbagh, HI; El-Taher, KE; Hegazy, GH1
Cao, L; Di, ZL; Jiang, Y; Lei, H; Tian, Y; Zhang, GJ1
Avoli, M; Benini, R; D'Antuono, M; de Guzman, P; Köhling, R1
Pillai, KK; Vohora, D1
Deepakumari, HN; Jayanna, BK; Prashanth, MK; Revanasiddappa, HD; Veeresh, B1
Albert, GW; Howard, MA; Schnizler, MK; Severson, MA; Welsh, MJ; Wemmie, JA; Ziemann, AE1
Ren, L; Tsang, SY; Wang, F; Xu, Z; Xue, H1
BALLIN, HM; GELLHORN, E1
Jain, R; Kaur, N; Krishnamoorthy, S; Meena, CL; Monga, V; Pawar, C; Rajput, SK; Sharma, SS1
Furutani, S; Itoh, A; Nakajima, H; Oshiro, H; Sugimoto, Y; Sun, S; Tanahashi, T; Yamada, J1
Barth, AL; Benedetti, BL; Sheehan, JJ1
Ares-Pena, FJ; Bregains, J; Cadarso-Suárez, C; Jorge-Barreiro, FJ; López-Martín, E; Relova-Quinteiro, JL1
Amabeoku, G1
Shalini, M; Sriram, D; Stables, JP; Yogeeswari, P1
Gholamreza, S; Golnaz, E; Mohammad, H; Reza, HM1
Héja, L; Kardos, J; Lasztóczi, B; Nyitrai, G1
Avoli, M; Biagini, G; D'Antuono, M; Gotman, J; Köhling, R; Ricalzone, S1
Behravan, E; Dadollahi, Z; Etemad, L; Heidari, MR; Mehrabani, M; Mehrabi, H; Pourzadeh-Hosseini, M1
Ingole, S; Jain, G; Jain, R; Kaur, N; Meena, CL; Monga, V; Rajput, SK; Sharma, SS; Singh, JN1
Arora, SK; Chakrabarti, A; Hota, D; Khanduja, KL; Prakash, A; Singh, S1
Araki, H; Kawasaki, H; Ochi, R; Suemaru, K1
Aladeokin, AC; Umukoro, S1
Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M1
Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G1
Adeyemi, OO; Aigbe, FR; Akindele, AJ; Fagbo, FI; Yemitan, OK1
Cachat, J; Chang, K; Dileo, J; Frank, K; Gaikwad, S; Gilder, T; Grossman, L; Kalueff, AV; Stewart, A; Suciu, C; Utterback, E; Wong, K; Wu, N1
El Idrissi, A; L'Amoreaux, WJ; Marsillo, A1
Jacobson, G; Melin, S; Sleigh, JW; Voss, LJ1
de Freitas, RM; Feng, D; Silva, Fde O; Silva, MG1
Abbasifard, M; Azimzadeh, BS; Behravan, E; Etemad, L; Heidari, M; Heidari, MR; Moshiri, M1
Alvarez-Figueiras, M; Ares-Pena, FJ; Cadarso-Suárez, C; Carballo-Quintás, M; López-Martín, E; Martínez-Silva, I1
Desaer, C; Ramakrishnan, L1
Bayliss, DA; Chen, X; Du, G; Kapur, J; Shu, S; Todorovic, MS1
Kokaia, M1
Adio, O; Fageyinbo, S; Sowemimo, AA1
Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R1
Cen, D; He, Z; Li, D; Li, P; Liang, L; Luo, X; Meng, Z1
Cho, S; Han, D; Jeon, YJ; Jin, YH; Jo, J; Kim, SB; Lee, SH; Shimizu, M; Yang, H; Yong, H; Yoon, M1
Banks, CN; Bruun, DA; Dhir, A; Hammock, BD; Inceoglu, B; Lein, PJ; McCoy, MR; Rogawski, MA; Sanborn, JR; Zolkowska, D1
Aslan, M; Deliorman Orhan, D; Orhan, IE; Orhan, N; Süküroğlu, M1
Baines, RA; Günay, C; Lin, WH; Marley, R; Prinz, AA1
Kamal, SM1
Abbas, SY; Abd-Alrahman, SN; Ahmed, GF; Ammar, RM; Ammar, YA; Farag, AA1
Du, XM; Guo, YT; Shoyama, Y; Sun, NY; Takizawa, N1
Paul, V; Subramanian, EH1
Bernardi, MM; Spinosa, Hde S; Stilck, SR1
Bough, KJ; Eagles, DA; Gudi, K; Han, FT; Rathod, AH1
Pericić, D; Svob, D1
Chaichantipyuth, C; Matsumoto, K; Murakami, Y; Sukma, M; Tohda, M; Watanabe, H1
Kalyoncu, NI; Tan, M; Tan, U1
Paul, V1
Chan, MN; Huen, MS; Leung, JW; Lui, WS; Ng, W; Wong, JT; Xue, H1
Jayakumar, R; Rajasekaran, K; Venkatachalam, K1
Ekambaram, P; Paul, V; Reddy, L2
Matsumoto, K; Murakami, Y; Nomura, H; Takahata, H; Taki, K; Watanabe, H1
Carvalho, JC; Carvalho, JE; Perazzo, FF; Rehder, VL1
MEIDINGER, F1
BURT, GS1
HAHN, F; OBERDORF, A1
GRUNDY, HF1
CARTER, SH; ROA, PD; STONE, WE; TEWS, JK1
VARDAPETIAN, GA1
SIGG, EB; WARNER, CL; YEN, HC1
CHUBB, FL; HAJDU, A; KOMLOSSY, J; LEE, CF; MCCOLL, JD1
BASIL, B; BLAIR, AM; HOLMES, SW1
FISCHER, R; LISS, L; SOLZE, DA1
GHOSH, JJ; SIKDAR, K1
SYTINSKY, IA; THINH, NT1
MAGISTRETTI, MJ; SETNIKAR, I1
AKINTONWA, DA; HATHWAY, DE; MALLINSON, A1
RAMWELL, PW; SHAW, JE1
Fei, J; Guo, LH; Ma, YH; Mei, ZT; Zhao, WJ1
Boehrer, A; Nehlig, A; Vergnes, M1
Ekambaram, P; Vanaja, P1
Ha, JH; Koo, BS; Lee, DU; Lee, SI1
Reddy, DS1
Ekambaram, P; Paul, V2
Hu, B; Karnup, S; Stelzer, A; Zhou, L1
Bidziński, A; Członkowska, AI; Krzaścik, P; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Szyndler, J; Taracha, E; Turzyńska, D; Walkowiak, J; Wisłowska, A; Zienowicz, M1
Arkhipov, VI; Kulagina, TP; Shevchenko, NA1
Flerov, MA; Gerasimova, IA; Tolstukhina, TI1
Lazić, J; Pericić, D; Svob Strac, D1
da Costa, F; de Oliveira, DL; Perry, ML; Scheibel, F; Schweigert, ID; Souza, DO; Wofchuk, ST1
Godlevskii, LS; Kobolev, EV1
Sierra-Marcuño, G; Sierra-Paredes, G; Vázquez-López, A1
Hitti, FL; Kim, U; Lee, KH; Leiter, JC; Roberts, DW; Shalinsky, MH1
Benedito, MA; Contó, MB; de Carvalho, JG1
Jazvinsćak Jembrek, M; Lazić, J; Pericić, D; Svob Strac, D1
Acharya, MM; Katyare, SS1
Ojewole, JA3
Ares-Pena, FJ; Gallego-Gómez, R; Jorge-Barreiro, FJ; López-Martín, E; Peleteiro-Fernández, M; Relova-Quinteiro, JL1
Hasan, Z; Otoom, S1
Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K1
Dhir, A; Kulkarni, SK; Naidu, PS1
Araújo, DA; Cruz, JS; de Almeida, RN; de Sousa, DP; Gonçalves, JC; Quintans-Júnior, L1
Núñez-Rodriguez, A; Oreiro-García, T; Sierra-Marcuño, G; Sierra-Paredes, G; Vázquez-López, A2
Pericić, D; Strac, DS; Vlainić, J2
Chen, Y; Hou, L; Li, K; Wang, J1
Amabeoku, GJ; Ojewole, JA1
Chang, SM; Ha, JH; Lee, JT; Lee, MG1
Avallone, R; Baraldi, M; Brusiani, F; Losi, G; Puia, G; Rivasi, M; Zanoli, P; Zavatti, M1
Chouinard, SW; Littleton, JT; Saraswati, S; Stilwell, GE1
Gütschow, M; Kubacka, M; Librowski, T; Meusel, M; Müller, CE; Scolari, S1
Amabeoku, GJ; Green, I; Kabatende, J1
Kubová, H; Mares, P; Tchekalarova, J1
Hyrc, K; Perry, G; Rothman, SM; Schmidt, BF; Yang, XF1
Akula, KK; Dhir, A; Kulkarni, SK1
Alves, PB; Antoniolli, AR; Blank, AF; Bonjardim, LR; Leite, BS; Lessa, NM; Quintans-Júnior, LJ; Santos, MR; Souza, TT1
Mustafa, AA; Salih, MA1
Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I1
Gillardin, JM; Heulard, I; Verleye, M1
Choi, SY; Choi, UK; Kang, JH; Kang, TC; Kim, DW; Kim, HT; Kim, JE; Kwak, SE; Kwon, OS; Lee, SJ1
Saito, S; Tokunaga, Y1
DeFeudis, FV; Elliott, KA2
Kelkar, MR; Sethy, VH; Sheth, UK1
Kádár, T; Penke, B; Pesti, A; Telegdy, G1
File, SE3
Calder, LD; Karler, R; Sangdee, P; Turkanis, SA1
Calder, LD; Karler, R; Turkanis, SA1
Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH1
Brahmapurikar, MT; Mateenuddin, M; Sadre, NL1
Leeb-Lundberg, F; Napias, C; Olsen, RW1
Flicker, C; Geyer, MA1
Hara, S; Kitagawa, H; Satoh, T1
Alpert, M; Triner, L; Verosky, M; Vulliemoz, Y1
Georgiev, VP; Lambadjieva, ND1
Olsen, RW1
Corda, MG; Costa, E; Guidotti, A1
Batts, CC; Cowen, PJ; Grahame-Smith, DG; Green, AR; Nutt, DJ1
Hablitz, JJ; Johnston, D; Lebeda, FJ1
Engel, J; Liljequist, S1
Gomes, C; Leite, JR; Pagliusi, SR; Trolin, G1
Kádár, T; Penke, B; Pesti, A; Telegdy, G; Tóth, G; Zarándi, M1
Ashton, D1
Jensen, LH; Petersen, EN1
File, SE; Green, AR; Nutt, DJ; Vincent, ND1
Manev, H; Pericić, D3
Jog, MV; Kulkarni, SK1
Mauss, EA; Wallenstein, MC1
Fujii, T; Ikeda, H; Nonaka, C1
Andreas, K; Dienel, A; Schmidt, J1
Ciesielski, L; Mandel, P; Simler, S1
Kovács, GL; Szabó, G; Telegdy, G2
Crider, AM; Hinko, CN; Seibert, K1
Collins, RC; Lothman, EW; Tearse, RG1
Foote, F; Gale, K1
Barbadoro, E; Graziani, G; Testa, R; Tirone, F1
File, SE; Simmonds, MA1
Hablitz, JJ1
Kofman, O; Mintz, M; Myslobodsky, M1
Ciesielski, L; Klein, M; Mandel, P; Simler, S1
Kalichman, MW1
Betin, C; Blavet, N; Clostre, F; DeFeudis, FV1
Collins, RC1
Menon, MK; Vivonia, CA1
Di Chiara, G; Imperato, A1
Kofman, O; Mintz, M; Myslobodsky, MS1
Pericić, D1
Burnham, WM; Kalichman, MW; Livingston, KE1
Myslobodsky, MS; Valenstein, ES1
Barker, JL; MacDonald, JF1
Javid, MJ; Stone, WE1
Burnham, WM; Kalichman, MW1
Bourn, WM; Reigel, CE1
Hiscock, JJ; Mackenzie, L; Medvedev, A; Willoughby, JO2
Brusentsov, AI; Godlevskiĭ, LS; Mikhaleva, II; Prudchenko, IA; Shandra, AA; Vast'ianov, RS; Zaporozhan, VN1
Abu-Laban, A; Hasan, Z; Khatib, S1
Brightman, T; Flynn, EJ; McArdle, JJ; Ortiz-Jimenez, E; Wu, WH; Ye, JH1
Godlevsky, LS; Mazarati, AM; Mikhaleva, II; Shandra, AA; Vastyanov, RS1
Dunham, L; Guillet, R1
Ali, BH; Banna, NR; Bashir, AK; Tanira, MO1
Imaizumi, M; Machida, H; Miyazaki, S1
Sainsbury, RS; Teskey, GC; Trepel, C; Valentine, PA1
Obara, N1
Basile, AS; Drugan, RC; Ferland, RJ; Ha, JH1
Chirkov, YP; Godlevsky, LS; Mazarati, AM; Panenko, AV; Shandra, AA; Tkachenko, IV1
Bolster, B; Dakshinamurti, K; Sharma, SK1
Adachi, I; Eigyo, M; Inoue, Y; Ishibashi, C; Koyabu, K; Matsushita, A; Murata, S; Sakaguchi, I; Shiomi, T; Ueda, M1
Freeman, P; Meade, HM; Seeley, NA; Sturman, G1
Cao, B; Hong, GX1
Askanazi, J; Manner, T; Petersen, AJ; Skeie, B; Steen, PA1
Getova, DP; Maslarova, JE; Nikolov, RK; Semkova, IS1
Kazi, M; Paul, V1
Hirayama, K; Matsuura, S; Murata, R1
Kenigs, V; Nores, WL; Olson, GA; Olson, RD; Thomas, J1
Amabeoku, GJ; Chikuni, O1
Balasubramaniam, E; Kazi, M; Paul, V; Sheela, S1
Nores, WL; Pariser, R; Thomas, J1
Borowski, TB; Kirkby, RD; Kokkinidis, L1
al-Hader, AF; Hasan, MM; Hasan, ZA; Takrouri, MS1
Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J1
Bernardi, MM; Gorniak, SL; Massoco, CO; Silva, MR; Spinosa, MS1
Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS1
Obrenovitch, TP; Urenjak, J; Zilkha, E1
Hiscock, JJ; Mackenzie, L; Willoughby, JO3
Carroll, DM; Grossman, AB; Kirkby, RD; Subramaniam, S1
Chiu, TH; Rosenberg, HC; Zhao, TJ1
Endo, T; Hara, S; Iwata, N; Kano, S; Kuriiwa, F; Mukai, T1
Bujas, M; Manev, H; Pericić, D1
Feigenbaum, JJ; Howard, SG1
Sierra-Marcuño, G; Sierra-Paredes, G1
Montagne-Clavel, J; Oliveras, JL1
Miyakawa, T; Niki, H; Tateishi, K; Yagi, T1
Boivin, E; Catérini, R; Clarençon, D; Ellis, P; Fatôme, M; Gourmelon, P; Hille, B; Kerckhoeve, A; Renaudin, M1
Cannizzaro, C; Cannizzaro, E; Gagliano, M; Mangiapane, N1
Cross, AJ; Green, AR; Misra, A; Murray, TK; Snape, MF1
Arkhipov, VI; Shilakina, TG1
Golovko, AI; Kliuntina, TV; Kurganova, TA; Sofronov, GA1
Chang, CC; Chiou, LC; Ling, JY1
Badran, S; Olpe, HR; Schmutz, M1
Mimaki, Y; Sashida, Y; Toshimizu, N; Yamada, K1
Bonsignori, A; Colombo, M; Dostert, P; Fariello, RG; Heidempergher, F; McArthur, RA; Pevarello, P; Pinciroli, V; Post, C; Salvati, P; Varasi, M1
Alexander, CB; Ellmore, TM; Kirkby, RD; Kokate, TG1
Aguilar-Veiga, E; Galán-Valiente, J; Mendez-Alvarez, E; Sierra-Marcuño, G; Sierra-Paredes, G; Soto-Otero, R; Vazquez-Illanes, MD1
Golovko, AI; Ivanov, MB; Shilov, VV; Sofronov, GA; Sviderskiĭ, OA1
Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML1
Amabeoku, GJ1
Mackenzie, L; Willoughby, JO1
Cornes, JM; Sierra-Marcuño, G; Sierra-Paredes, G1
Jayakumar, AR; Jayakumar, R; Paul, V; Puviarasan, K; Sujatha, R1
Kim, DC; Todd, MM1
Boehrer, A; Marescaux, C; Reibel, S; Simler, S; Vergnes, M1
Bijak, M; Chojnacka-Wójcik, E; Czuczwar, SJ; Kroczka, B; Kłodzińska, A; Pilc, A; Swiader, M1
Chae, WG; Choi, H; Choi, J; Jahng, Y; Je, SM; Kim, EK; Kim, TH; Kim, YC; Lee, ES; Park, M; Zhao, LX1
Jayakumar, AR; Paul, V1
da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP1
Aguilar-Veiga, E; Galán-Valiente, J; Sierra-Marcuño, G; Sierra-Paredes, G; Vazquez-Illanes, MD1
Atapour, N; Kalantaripour, TP; Niazi, M; Nourpanah, M1
Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J1
Senra-Vidal, A; Sierra-Marcuño, G; Sierra-Paredes, G1
Jazvinscak, M; Mirkovic, K; Pericic, D; Svob, D2
Yakimovskii, A1
Arkhipov, VI; Kolomiitseva, IK; Kulagina, TP1
Paul, V; Rajasekaran, K; Reddy, PL1
Bidziński, A; Członkowska, AI; Krzaścik, P; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J1
Jayakumar, AR; Vanaja, P1
Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K1
Jazvinsćak Jembrek, M; Mirković Kos, K; Pericić, D; Svob, D1
Arkhipov, V1
Hiscock, JJ; Mackenzie, L; Medvedev, A; Pope, KJ; Willoughby, JO1
Amabeoku, GJ; Bienvenu, E; Eagles, PK; Scott, G; Springfield, EP1
Chopde, CT; Kasture, SB; Kasture, VS1
Bidziński, A; Członkowska, AI; Kostowski, W; Krzaścik, P; Maciejak, P; Plaznik, A; Szyndler, J; Walkowiak, J1
Stach, R1
Chimote, KV; Moghe, PJ1
Bures, J; Islam, S1
Lothman, EW; Somjen, GG1
Bures, J; Ueda, M1
Georgiev, VP; Petkova, BP2
McQueen, JK; Woodbury, DM1
Costa, E; Guidotti, A; Mao, CC; Suria, A1
Georgiev, VP; Petkova-Radkova, BP2
Matthews, WD; McCafferty, GP1
Stone, WE1
Rose, D1
Ciesielski, L; Kempf, E; Mack, G; Maitre, M; Mandel, P; Simler, S1
Killam, KF; Rosenkranz, RP1
Fukumori, R; Kitagawa, H; Minegishi, A; Nakagawa, I; Satoh, T; Yanaura, S1
Mansour, R; Myslobodsky, MS1
György, L1
Anhut, H; Hertting, G; Steinhauer, HB1
Simon, P; Soubrie, P1
Bigler, ED1
Gartside, IB; Hayes, AG; Straughan, DW1
Georgiev, V1
Frey, HH; Löscher, W1
Breuker, EL; Dennis, BJ; Duong, T; Kerr, DI; Prager, RH; Ward, AD1
Bures, J; Jonescu, E; Welzl, H1
Kim, HJ; Routtenberg, A1
Cowen, JS; Maxson, SC1
Mulas, A; Pedata, F; Pepeu, G; Pepeu, IM1
Georgiev, V; Markovska, V1
Georgiev, VP; Markovska, VL1
Conforti, N; Harel, D; Lavy, S; Raday, N1
Borzek, G; Bures, J; von Schwarzenfeld, I1
Meldrum, BS; Stephenson, JD1
Marsden, CD; Meldrum, B; Pycock, C; Tarsy, D1
Peesker, SJ; Wood, JD1
Barbeau, A; Davidson, DL1
Serratosa, J; Trullas, R; Tusell, JM; Vendrell, M1
Bohuslav, T; Kubová, M; Mares, P1
Golovko, AI; Sofronov, GA1
Askanazi, J; Jellum, E; Manner, T; Petersen, AJ; Skeie, B; Steen, PA1
Godlevskiĭ, LS; Oleĭnik, AA; Shandra, AA; Vikhrestiuk, SL1
Mazarati, AM; Telegdy, G1
Mizuki, Y; Sekimoto, M; Ushijima, I; Yamada, M1
Godlevskiĭ, LS; Mazarati, AM; Shandra, AA; Vast'ianov, RS1
Habibuddin, M; Pal, M; Pal, SP1
Harro, J; Lang, A; Soosaar, A; Vasar, E1
Bertolini, A; Marrama, D; Sandrini, M; Vergoni, AV1
Aley, KO; Kulkarni, SK1
Bitran, D; Kellogg, CK; Primus, RJ1
Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Mazarati, AM; Nguyen, TT; Shandra, AA1
Bierkamper, GG; Smith, KA1
Lothman, EW; Stringer, JL1
Drummer, HL; Woolley, DE1
Dai, KS; Drummer, HL; Hasan, ZA; Woolley, DE1
Liljequist, S1
Bandyopadhyay, AA; Godlevsky, LS; Lobenko, AA; Mazarati, AM; Shandra, AA1
Dreier, JP; Heinemann, U1
Lok, SY; Meldrum, BS; Millan, MH; Obrenovitch, TP; Sarna, GS; Symon, L1
Araki, H; Sano, M; Shimada, C; Tanaka, S1
Carboni, G; Corda, MG; Frau, V; Giorgi, O; Lecca, D; Orlandi, M1
Faktorová, M; Kubová, H; Mares, P1
Rizzi, M; Samanin, R; Serafini, R; Stasi, MA; Vezzani, A; Viganò, G1
Canney, DJ; Covey, DF; Ferrendelli, JA; Holland, KD; Levine, JA; McKeon, AC1
McLean, JH; Thomas, J1
Helton, DR; Williams, PD1
Batatinha, MJ; Bernardi, MM; De Souza-Spinosa, H; Giorgi, R1
Dai, KS; Woolley, DE1
Burke, K; Chandler, CJ; Starr, BS; Starr, MS1
Alkana, RL; Finn, DA; Jones, BL; Kobayashi, LS; Syapin, PJ1
Becker, A; Grecksch, G; Matthies, H1
Mares, P; Rokyta, R; Velísek, L; Velísková, J1
Depaulis, A; Kempf, E; Liu, Z; Marescaux, C; Vergnes, M1
De Barry, J; Mathis, C; Ungerer, A1
Kádár, T; Schally, AV; Telegdy, G1
Jones, RS; Lambert, JD1
Mehta, AK; Ticku, MK3
Dragunow, M1
Campbell, JA; Greenwood, TD; Rathman, TL; Sleevi, MC; Wolfe, JF1
Thomas, J2
Depaulis, A; Liu, Z; Marescaux, C; Vergnes, M1
Kaneto, H; Miwa, T; Nakamura, J; Sasaki, H; Shibasaki, J1
Depaulis, A; Liu, Z; Marescaux, C; Micheletti, G; Vergnes, M; Warter, JM1
Kulkarni, SK; Mehta, AK; Ticku, MK1
Fishman, BE; Gianutsos, G3
Dudek, BC; Kim, D; Phillips, TJ1
Mizukawa, K; Otsuka, N; Watanabe, H1
Ho, IK; Ito, Y; Lim, DK; Nabeshima, T1
Paul, SM; Schwartz, RD; Seale, TW; Skolnick, P1
Kulkarni, SK; Ticku, MK2
Curran, T; Hempstead, J; Macgregor-Leon, PF; Mitchelmore, C; Morgan, JI; Sonnenberg, JL1
Pierson, MG; Smith, KL; Swann, JW1
Abdul-Ghani, AS; el-Lati, S; Ghneim, H; Saca'an, A1
Korotzer, A; Pfaff, DW; Schwartz-Giblin, S1
Bhadra, S; Idemudia, SO; Lal, H1
Georgieva, J1
Palermo-Neto, J; Sandoval, MR1
Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Makul'kin, RF; Mazarati, AM; Shandra, AA1
Ticku, MK1
Gale, RG; Little, HJ; Nutt, DJ; Standing, BL; Taylor, SC1
Ben-Shachar, D; Laufer, D; Livne, E; Silbermann, M1
Goldberg, O; Teichberg, VI1
Frenk, H; Liban, A; Teichberg, VI; Urca, G1
Kent, AP; Webster, RA1
Anderson, MC; Chung, EY; Van Woert, MH1
Hutchison, AJ; Lehmann, J; McPherson, SE; Mondadori, C; Murphy, DE; Schmutz, M; Sinton, CM; Steel, DJ; Tsai, C; Williams, M1
Hara, T; Kawazawa, S; Mizuki, Y; Ushijima, I; Yamada, M1
Rastogi, SK; Ticku, MK1
Beitz, AJ; Larson, AA1
Bourn, WM; Garrett, RL1
Maĭmets, MO; Nurk, AM; Riago, LK; Soosaar, AKh; Vasar, EE1
Dewhurst, DG1
Little, HJ; Nutt, DJ; Taylor, SC1
Croucher, M; Gueremy, C; Le Fur, G; Legrand, JJ; Mazadier, M; Meldrum, B; Mizoule, J; Ollat, C; Uzan, A1
Anić-Stojiljković, S; Manev, H; Pericić, D1
Centra, M; Keeting, PE; Lysz, TW; Markey, K1
Laporte, AM; Soubrié, P; Thiébot, MH1
Brioni, JD; McGaugh, JL1
Kantarev, N; Parisheva, Z; Toreva, D1
Bayardo, F; Buzsáki, G; Gage, FH; Ponomareff, G; Shaw, T1
Crabbe, JC; Feller, DJ; Harris, RA1
Lister, RG; Nutt, DJ1
Bernasconi, R; Christen, P; Hafner, T; Klein, M; Martin, P; Portet, C; Schmutz, M1
Georgiev, V; Getova, D1
Burdette, LJ; Dyer, RS1
Evans, D; Smith, JC1
Cain, DP1
Durand, D1
Piredda, SG; Swinyard, EA; Woodhead, JH1
Geber, J; Manev, H; Pericić, D1
Calderazzo-Filho, LS; Cavalheiro, EA; Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, WA1
Davis, JM; Himwich, WA1
Cowan, A; Harry, EJ1
Bravo, MC; Negishi, K; Verzeano, M1
Atsev, E; Tchavdarov, D; Usunoff, G1
Barrada, O; Oftedal, SI1
Vernadakis, A; Woodbury, DM1
Hill, RG; Simmonds, MA; Straughan, DW1
Hathway, DE; Mallinson, A1
Bean, JW; Thom, B; Zee, D1
Chusid, JG; Kopeloff, LM1
Abrahams, DE; Wood, JD1
Frank, GB; Jhamandas, K2
Kimura, R; Murata, T1
Selye, H1
Andry, ML; Luttges, MW1
Eichbaum, FW; Yasaka, J1
Araki, Y; Ueki, S1
Clarke, G; Hill, RG; Straughan, DW1
Radomski, MW; Watson, WJ1
Brown, DJ; Stone, WE1
Baxter, MG; Miller, AA; Webster, RA1
Goldstein, DB1
Borowitz, JL; Sangiah, S; Yim, GK1
Baker, WW; Kratky, M1
Saito, S1
Swinyard, EA1
Tudor, I1
Fujiwara, M; Matsuo, S; Shimamoto, K1
Dadkar, NK; Damle, SK; Gaitonde, B1
Yoshino, T1
Elliott, KA; Yoshino, Y3
Radomski, MW; Wood, JD1
Hahn, F; May, HU1
Hata, T; Kita, T; Murakami, T; Okage, T1
Watson, WJ; Wood, JD1
Ferngren, H1
Adachi, S; Ishida, R; Kodama, T; Kowa, Y; Nishizawa, Y1
Atsev, E; Chavdarov, D; Usunoff, G2
Atsev, E; Chavdarov, D; Mihailov, S; Usunoff, G1
Hahn, F; Kretzschmar, R; Meyer, HJ1
Iwata, H; Oka, T; Shikimi, T1
Kuriyama, K; Roberts, E; Rubinstein, MK1

Reviews

9 review(s) available for picrotoxin and Seizures

ArticleYear
Light-activated channels in acute seizures.
    Epilepsia, 2011, Volume: 52 Suppl 8

    Topics: Animals; Bacterial Proteins; Convulsants; Electric Stimulation; Halorhodopsins; Hippocampus; Humans; Light; Luminescent Proteins; Membrane Potentials; Mice; Models, Biological; Organ Culture Techniques; Picrotoxin; Seizures; Transfection

2011
Changes in CNS sensitivity to cannabinoids with repeated treatment: tolerance and auxoesthesia.
    NIDA research monograph, 1984, Volume: 54

    Topics: Animals; Brain; Cannabidiol; Cannabinoids; Dronabinol; Drug Tolerance; Electroshock; Kindling, Neurologic; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures

1984
The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs.
    Molecular and cellular biochemistry, 1981, Sep-25, Volume: 39

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Bicuculline; Brain; Chlorides; Convulsants; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Picrotoxin; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures; Synaptic Membranes

1981
Gamma hydroxybutyrate is not a GABA agonist.
    Progress in neurobiology, 1996, Volume: 50, Issue:1

    Topics: 4-Butyrolactone; Animals; Central Nervous System; Convulsants; Electroencephalography; GABA Agonists; gamma-Aminobutyric Acid; Humans; Mammals; Muscle Contraction; Picrotoxin; Rabbits; Rats; Receptors, GABA; Respiration; Seizures; Sodium Oxybate

1996
New concepts on the mechanism of action of benzodiazepines.
    Life sciences, 1975, Jul-15, Volume: 17, Issue:2

    Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Ganglia, Autonomic; Glycine; Humans; Isoniazid; Medulla Oblongata; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Receptors, Drug; Seizures; Sensory Receptor Cells; Spinal Cord; Strychnine; Substantia Nigra

1975
Response of brain amino acids to drugs and environmental conditions.
    Advances in psychobiology, 1972, Volume: 1

    Topics: Amino Acids; Aminobutyrates; Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Chlorpromazine; Environment; Ethanol; Glutamates; Guinea Pigs; Haloperidol; Hibernation; Hypoxia; Insulin; Mice; Picrotoxin; Rabbits; Rats; Reserpine; Seizures; Sleep

1972
[Biochemistry of epilepsy].
    Shinkei kenkyu no shimpo. Advances in neurological sciences, 1968, Volume: 12, Issue:3

    Topics: Acetylcholine; Aminobutyrates; Animals; Brain; Electroencephalography; Epilepsy; Glutamates; Glutamine; Humans; Muscle Cramp; Pentylenetetrazole; Picrotoxin; Seizures

1968
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
    Epilepsia, 1969, Volume: 10, Issue:2

    Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; Electroshock; Humans; Methionine Sulfoximine; Methods; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine; Thiosemicarbazones; Trimethadione; Urea

1969
[Biochemical aspects of seizures in convulsive diseases].
    Studii si cercetari de neurologie, 1969, Volume: 14, Issue:3

    Topics: Ammonia; Animals; Biochemical Phenomena; Biochemistry; Cell Membrane; Epilepsy; Fatty Acids; Humans; Methionine; Nervous System; Neurons; Picrotoxin; Potassium; Seizures; Sodium; Strychnine

1969

Other Studies

466 other study(ies) available for picrotoxin and Seizures

ArticleYear
Neuro-pharmacological evaluation of anticonvulsant and neuroprotective activity of Cocculus laurifolius leaves in wistar rats.
    Metabolic brain disease, 2019, Volume: 34, Issue:4

    Topics: Animals; Anticonvulsants; Apoptosis; Brain; Cocculus; Disease Models, Animal; Female; Male; Neurons; Neuroprotective Agents; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Seizures; Strychnine

2019
GABA
    International journal of molecular sciences, 2022, Mar-31, Volume: 23, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy-Related Proteins; Brain Injuries, Traumatic; Disease Models, Animal; Epilepsy; Mice; Picrotoxin; Receptors, GABA-A; Seizures

2022
Digoxin at sub-cardiotonic dose modulates the anticonvulsive potential of valproate, levetiracetam and topiramate in experimental primary generalized seizures.
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2022,Spring, Volume: 71, Issue:2

    Topics: Animals; Anticonvulsants; Camphor; Cardiotonic Agents; Digoxin; Levetiracetam; Male; Mice; Picrotoxin; Seizures; Strychnine; Topiramate; Valproic Acid

2022
Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
    Journal of food biochemistry, 2022, Volume: 46, Issue:10

    Topics: Animals; Anticonvulsants; Antioxidants; Arginine; Clerodendrum; Cyclooxygenase 2; Flumazenil; Guanosine Monophosphate; Kainic Acid; Lamiaceae; Methylene Blue; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Picrotoxin; Plant Extracts; Receptors, GABA-A; Seizures; Soluble Guanylyl Cyclase; Spasm

2022
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2022,Fall, Volume: 71, Issue:5

    Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Molecular Docking Simulation; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine

2022
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
    Journal of ethnopharmacology, 2023, Mar-01, Volume: 303

    Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin; Pilocarpine; Plant Extracts; Seizures; Strychnine; Water

2023
The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin.
    Signal transduction and targeted therapy, 2023, 03-10, Volume: 8, Issue:1

    Topics: Animals; Calcineurin; Epilepsy; Mice; Picrotoxin; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Seizures

2023
Noradrenergic stimulation of α
    Scientific reports, 2023, 05-19, Volume: 13, Issue:1

    Topics: Animals; Mice; Norepinephrine; Picrotoxin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Seizures

2023
Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists.
    Neurotoxicology, 2020, Volume: 76

    Topics: Animals; Brain; Bridged-Ring Compounds; Drug Evaluation, Preclinical; GABA-A Receptor Antagonists; Pentylenetetrazole; Picrotoxin; Seizures; Zebrafish

2020
Potential Mechanisms Involved in the Anticonvulsant Effect of Methanol Extract of
    Central nervous system agents in medicinal chemistry, 2020, Volume: 20, Issue:2

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Methanol; Mice; Picrotoxin; Plant Extracts; Plants, Medicinal; Seizures; Toxicity Tests, Acute

2020
Synthesis and Evaluation of Anticonvulsant Activity of Some Schiff Bases of 7-Amino-1,3-dihydro-2H-1,4-benzodiazepin-2-one.
    Chemistry & biodiversity, 2020, Volume: 17, Issue:9

    Topics: Animals; Anticonvulsants; Azepines; Behavior, Animal; Female; Male; Models, Molecular; Molecular Structure; Picrotoxin; Rats; Rats, Wistar; Schiff Bases; Seizures

2020
Sweet poison: seizures in two patients with
    Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:6

    Topics: Adult; Female; Humans; Picrotoxin; Plants, Toxic; Seizures; Sesquiterpenes

2021
Pharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in mice.
    Journal of ethnopharmacology, 2021, May-10, Volume: 271

    Topics: Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Male; Medicine, Traditional; Mice; Mortality; Pentylenetetrazole; Picrotoxin; Plant Extracts; Ruta; Seizures

2021
Electrophysiological field potential identification of an intact GABAergic system in mouse cortical slices.
    Brain research, 2021, 04-01, Volume: 1756

    Topics: Action Potentials; Animals; Brain; Electrophysiological Phenomena; gamma-Aminobutyric Acid; Mice, Inbred C57BL; Neurons; Picrotoxin; Seizures

2021
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
    Journal of ethnopharmacology, 2021, May-23, Volume: 272

    Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mice; Pentylenetetrazole; Phytochemicals; Picrotoxin; Plant Bark; Plant Extracts; Plant Stems; Psychotria; Rats, Wistar; Seizures; Semicarbazides; Sleep; Sleep Latency; Strychnine; Water

2021
Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome.
    Scientific reports, 2021, 05-04, Volume: 11, Issue:1

    Topics: Animals; Diazepam; Disease Models, Animal; Down Syndrome; Electrophysiological Phenomena; Female; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Picrotoxin; Seizures; Synaptic Transmission

2021
Focal cortical seizures start as standing waves and propagate respecting homotopic connectivity.
    Nature communications, 2017, 08-09, Volume: 8, Issue:1

    Topics: Animals; Mice, Transgenic; Picrotoxin; Seizures; Visual Cortex

2017
Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures.
    Journal of neuroinflammation, 2019, Mar-28, Volume: 16, Issue:1

    Topics: Animals; Brain; Cells, Cultured; Convulsants; Cytokines; Disease Models, Animal; Gene Expression Regulation; Interleukin-10; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Nucleic Acids; Picrotoxin; RNA, Small Interfering; Seizures; Signal Transduction; STAT3 Transcription Factor

2019
Rosmarinic acid improves oxidative stress parameters and mitochondrial respiratory chain activity following 4-aminopyridine and picrotoxin-induced seizure in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:11

    Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Cinnamates; Depsides; Disease Models, Animal; DNA Damage; Electron Transport Complex II; Hippocampus; Mice; Mitochondria; Neuroprotective Agents; Oxidative Stress; Picrotoxin; Rosmarinic Acid; Seizures

2019
Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility.
    Epilepsia, 2013, Volume: 54, Issue:4

    Topics: Animals; Anticonvulsants; Behavior, Animal; Databases, Genetic; Electroencephalography; Enzyme Inhibitors; Feedback, Physiological; GABA Antagonists; Gene Expression Regulation, Enzymologic; Glutathione; Lactoylglutathione Lyase; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscarinic Agonists; Picrotoxin; Pilocarpine; Pyruvaldehyde; Receptors, GABA-A; Seizures; Status Epilepticus

2013
Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices.
    Brain research, 2013, Apr-24, Volume: 1507

    Topics: Animals; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; In Vitro Techniques; Magnesium; Male; MAP Kinase Signaling System; Picrotoxin; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Somatosensory Cortex

2013
Seizure protection by intrapulmonary delivery of midazolam in mice.
    Neuropharmacology, 2013, Volume: 73

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Routes; Kainic Acid; Male; Mice; Midazolam; Pentylenetetrazole; Picrotoxin; Seizures

2013
Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures.
    Cellular and molecular neurobiology, 2013, Volume: 33, Issue:6

    Topics: Acetamides; Animals; Brain; Catalase; Female; Lipid Peroxidation; Mice; Nitrites; Oxidative Stress; Pentylenetetrazole; Picrotoxin; Pilocarpine; Seizures; Strychnine

2013
The effect of simvastatin on picrotoxin-induced seizure in mice.
    JPMA. The Journal of the Pakistan Medical Association, 2012, Volume: 62, Issue:11

    Topics: Animals; Chi-Square Distribution; Hippocampus; Mice; Mice, Inbred BALB C; Picrotoxin; Pyramidal Cells; Random Allocation; Seizures; Simvastatin; Statistics, Nonparametric

2012
Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved.
    European review for medical and pharmacological sciences, 2013, Volume: 17, Issue:16

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; gamma-Aminobutyric Acid; Hypericum; Male; Medicine, Traditional; Mice; Nitric Oxide; Pentylenetetrazole; Picrotoxin; Plant Extracts; Seizures; Time Factors

2013
Antisense reduction of tau in adult mice protects against seizures.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jul-31, Volume: 33, Issue:31

    Topics: Age Factors; Animals; Anticonvulsants; Central Nervous System; Convulsants; Disease Models, Animal; Gait Disorders, Neurologic; Gene Expression Regulation; Infusions, Intraventricular; Lactic Acid; Locomotion; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Oligonucleotides, Antisense; Pentylenetetrazole; Picrotoxin; Seizures; tau Proteins

2013
Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling.
    Neuroscience, 2014, Jan-17, Volume: 257

    Topics: Action Potentials; Animals; Anticonvulsants; Berberine Alkaloids; Carbamazepine; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Electrodes, Implanted; Finasteride; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Midazolam; Picrotoxin; Progesterone; Seizures

2014
The analgesic and anticonvulsant effects of piperine in mice.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2013, Volume: 64, Issue:6

    Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anticonvulsants; Benzodioxoles; Hot Temperature; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pentylenetetrazole; Picrotoxin; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Seizures

2013
Comparison between the effect of propofol and midazolam on picrotoxin-induced convulsions in rat.
    Physiology & behavior, 2014, Apr-10, Volume: 128

    Topics: Administration, Intravenous; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Female; Midazolam; Picrotoxin; Propofol; Rats, Sprague-Dawley; Seizures; Time Factors

2014
Evaluation of anticonvulsant actions of dibromophenyl enaminones using in vitro and in vivo seizure models.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Action Potentials; Animals; Anticonvulsants; CA1 Region, Hippocampal; Culture Media; Cyclohexanones; Cyclohexylamines; Electric Stimulation; Electroshock; Locomotion; Magnesium; Male; Microtomy; Phenytoin; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Tissue Culture Techniques

2014
Synthesis, anticonvulsant, sedative and anxiolytic activities of novel annulated pyrrolo[1,4]benzodiazepines.
    International journal of molecular sciences, 2014, Sep-18, Volume: 15, Issue:9

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Exploratory Behavior; Heterocyclic Compounds, 4 or More Rings; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Molecular Structure; Pentobarbital; Picrotoxin; Reflex, Abnormal; Seizures; Strychnine

2014
Experimental investigation of pharmacodynamics and pharmacokinetics of carbamazepine nanoemulsion.
    Bulletin of experimental biology and medicine, 2014, Volume: 157, Issue:6

    Topics: Animals; Anticonvulsants; Biological Availability; Blood-Brain Barrier; Diethylcarbamazine; Electric Stimulation; Emulsions; Male; Mice; Nanostructures; Picrotoxin; Seizures; Statistics, Nonparametric

2014
Synthesis, anticonvulsant activity and molecular modeling study of some new hydrazinecarbothioamide, benzenesulfonohydrazide, and phenacylacetohydrazide analogues of 4(3H)-quinazolinone.
    Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Hydrazines; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Picrotoxin; Quinazolinones; Seizures; Structure-Activity Relationship; Sulfonamides; Thiourea

2015
Down-regulation of Homer1b/c protects against chemically induced seizures through inhibition of mTOR signaling.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:4

    Topics: Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; Down-Regulation; Glycine; Hippocampus; Homer Scaffolding Proteins; Maze Learning; Mice; PC12 Cells; Pentylenetetrazole; Phenylacetates; Phosphorylation; Picrotoxin; Rats; Receptor, Metabotropic Glutamate 5; Ribosomal Protein S6 Kinases; RNA Interference; Seizures; Signal Transduction; TOR Serine-Threonine Kinases

2015
Hypersynchronous ictal onset in the perirhinal cortex results from dynamic weakening in inhibition.
    Neurobiology of disease, 2016, Volume: 87

    Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cations, Monovalent; Cerebral Cortex; Excitatory Amino Acid Antagonists; GABA Antagonists; Neurons; Periodicity; Phosphinic Acids; Picrotoxin; Piperazines; Potassium; Propanolamines; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Seizures; Tissue Culture Techniques

2016
NORADRENERGIC MECHANISMS IN THE PROCONVULSANT EFFECTS OF BUSPIRONE.
    Indian journal of physiology and pharmacology, 1999, Volume: 43, Issue:1

    Topics: Animals; Anticonvulsants; Buspirone; Male; Mice; Picrotoxin; Receptors, Adrenergic, alpha-2; Seizures

1999
Synthesis and Anticonvulsant Activity of N-(Substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides.
    Archiv der Pharmazie, 2016, Volume: 349, Issue:7

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Methaqualone; Mice; Pentylenetetrazole; Picrotoxin; Quinazolines; Seizures; Structure-Activity Relationship; Valproic Acid

2016
Seizure termination by acidosis depends on ASIC1a.
    Nature neuroscience, 2008, Volume: 11, Issue:7

    Topics: Acid Sensing Ion Channels; Acidosis; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Carbon Dioxide; Electroencephalography; Female; Hippocampus; Hydrogen-Ion Concentration; Interneurons; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Knockout; Nerve Tissue Proteins; Patch-Clamp Techniques; Pentylenetetrazole; Picrotoxin; Seizures; Sodium Channels; Time Factors

2008
GABA A receptor subtype selectivity underlying selective anxiolytic effect of baicalin.
    Neuropharmacology, 2008, Volume: 55, Issue:7

    Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Cell Line; Convulsants; Data Interpretation, Statistical; Electrophysiology; Flavonoids; Male; Mice; Mice, Inbred ICR; Patch-Clamp Techniques; Picrotoxin; Postural Balance; Radioligand Assay; Receptors, GABA-A; Seizures

2008
Effect of optic and acoustic stimuli on the cortex and hypothalamus under conditions of picrotoxin convulsions.
    Archives of neurology and psychiatry, 1948, Volume: 59, Issue:4

    Topics: Cerebral Cortex; Hypothalamus; Picrotoxin; Seizures

1948
Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog.
    Epilepsy & behavior : E&B, 2009, Volume: 14, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Cardiovascular System; Central Nervous System Stimulants; Cerebrovascular Circulation; Convulsants; Electroshock; Hypnotics and Sedatives; Kainic Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Seizures; Sleep; Theophylline; Thyrotropin; Thyrotropin-Releasing Hormone

2009
Effects of extracts and neferine from the embryo of Nelumbo nucifera seeds on the central nervous system.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2008, Volume: 15, Issue:12

    Topics: Animals; Anti-Anxiety Agents; Benzylisoquinolines; Body Temperature; Male; Mice; Mice, Inbred ICR; Motor Activity; Nelumbo; Phytotherapy; Picrotoxin; Plant Extracts; Rotarod Performance Test; Seeds; Seizures; Sleep; Strychnine

2008
Anticonvulsant effects of the BK-channel antagonist paxilline.
    Epilepsia, 2009, Volume: 50, Issue:4

    Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Indoles; Mice; Mice, Inbred C57BL; Neocortex; Pentylenetetrazole; Picrotoxin; Potassium Channel Blockers; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Seizures; Time Factors

2009
The action of pulse-modulated GSM radiation increases regional changes in brain activity and c-Fos expression in cortical and subcortical areas in a rat model of picrotoxin-induced seizure proneness.
    Journal of neuroscience research, 2009, May-01, Volume: 87, Issue:6

    Topics: Analysis of Variance; Animals; Brain; Disease Models, Animal; Electroencephalography; Gene Expression; Male; Picrotoxin; Proto-Oncogene Proteins c-fos; Radiation Dosage; Radio Waves; Rats; Rats, Sprague-Dawley; Seizures

2009
Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice.
    Human & experimental toxicology, 2008, Volume: 27, Issue:11

    Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Epilepsy, Generalized; Lethal Dose 50; Male; Methanol; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Plant Extracts; Plant Leaves; Polygalaceae; Seizures; Solvents; Water

2008
Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2009, Volume: 63, Issue:3

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Semicarbazones; Structure-Activity Relationship; Strychnine; Toxicity Tests

2009
Effect of methanolic extract of Hyoscymus niger L. on the seizure induced by picritoxin in mice.
    Pakistan journal of pharmaceutical sciences, 2009, Volume: 22, Issue:3

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Seeds; Seizures; Solanaceae

2009
Synchronization of GABAergic inputs to CA3 pyramidal cells precedes seizure-like event onset in juvenile rat hippocampal slices.
    Journal of neurophysiology, 2009, Volume: 102, Issue:4

    Topics: Aging; Animals; CA3 Region, Hippocampal; Chlorides; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Intracellular Space; Magnesium Deficiency; Male; Periodicity; Picrotoxin; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Seizures; Synapses; Synaptic Transmission; Time Factors

2009
Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Brain; Carbamazepine; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Entorhinal Cortex; Fructose; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Topiramate; Valproic Acid

2010
Study of antiseizure effects of Matricaria recutita extract in mice.
    Annals of the New York Academy of Sciences, 2009, Volume: 1171

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Matricaria; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Seizures; Survival Analysis; Survival Rate; Time Factors

2009
Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parameters.
    Epilepsy research, 2009, Volume: 87, Issue:2-3

    Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Electrophysiology; Electroshock; Ganglia, Spinal; Kainic Acid; Male; Mice; Motor Activity; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Statistics, Nonparametric; Thyrotropin-Releasing Hormone

2009
Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 94, Issue:3

    Topics: Animals; Convulsants; Disease Models, Animal; Electrophoresis, Agar Gel; Enzyme Inhibitors; Finasteride; Indomethacin; Male; Mice; Neurons; Picrotoxin; Pregnanolone; Seizures

2010
Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice.
    Acta medica Okayama, 2009, Volume: 63, Issue:5

    Topics: Aminophylline; Animals; Anticonvulsants; Apnea; Bronchodilator Agents; Child; Convulsants; Diazepam; Dizocilpine Maleate; Fever; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; Humans; Infant; Japan; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Picrotoxin; Purinergic P1 Receptor Agonists; Saccharomyces cerevisiae; Seizures

2009
Evaluation of the anti-stress and anticonvulsant activities of leaf extract of Alchornea cordifolia in mice.
    Journal of ethnopharmacology, 2010, Feb-17, Volume: 127, Issue:3

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Euphorbiaceae; Fatigue; Female; Male; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures; Stress, Psychological; Swimming

2010
Anticonvulsant activity of DNS II fraction in the acute seizure models.
    Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3

    Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbred Strains; Pakistan; Pentylenetetrazole; Phenytoin; Picrotoxin; Ranunculaceae; Seizures; Skin Neoplasms

2010
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
    Neurological research, 2010, Volume: 32, Issue:9

    Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; GABA Modulators; gamma-Aminobutyric Acid; Organoselenium Compounds; Phenobarbital; Picrotoxin; Rats; Seizures

2010
Anticonvulsant, anxiolytic and sedative activities of the aqueous root extract of Securidaca longepedunculata Fresen.
    Journal of ethnopharmacology, 2010, Jul-20, Volume: 130, Issue:2

    Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Hexobarbital; Hypnotics and Sedatives; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Picrotoxin; Plant Extracts; Plant Roots; Securidaca; Seizures; Sleep; Strychnine; Time Factors

2010
Modeling seizure-related behavioral and endocrine phenotypes in adult zebrafish.
    Brain research, 2010, Aug-12, Volume: 1348

    Topics: Animals; Behavior, Animal; Caffeine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Hydrocortisone; Locomotion; Male; Numerical Analysis, Computer-Assisted; Pentylenetetrazole; Phenotype; Picrotoxin; Reaction Time; Seizures; Statistics, Nonparametric; Zebrafish

2010
Pharmacological characterization of GABAA receptors in taurine-fed mice.
    Journal of biomedical science, 2010, Aug-24, Volume: 17 Suppl 1

    Topics: Animals; Behavior, Animal; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mice; Picrotoxin; Receptors, GABA-A; Seizures; Taurine

2010
GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity.
    Brain research, 2010, Nov-11, Volume: 1360

    Topics: Animals; Connexins; Electroencephalography; Electrophysiological Phenomena; Etomidate; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junction delta-2 Protein; Gap Junctions; Hypnotics and Sedatives; In Vitro Techniques; Magnesium Deficiency; Male; Mefloquine; Mice; Mice, Inbred C57BL; Mice, Knockout; Picrotoxin; Receptors, GABA-A; Seizures

2010
Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice.
    Fitoterapia, 2011, Volume: 82, Issue:2

    Topics: Animals; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Ketones; Male; Mice; Motor Activity; Pentylenetetrazole; Phytotherapy; Picrotoxin; Piperidines; Plant Extracts; Plant Leaves; Seizures; Senna Plant

2011
Investigation of Hypericum perforatum extract on convulsion induced by picrotoxin in mice.
    Pakistan journal of pharmaceutical sciences, 2011, Volume: 24, Issue:2

    Topics: Animals; Hypericum; Male; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Seizures

2011
A study of neurotoxic biomarkers, c-fos and GFAP after acute exposure to GSM radiation at 900 MHz in the picrotoxin model of rat brains.
    Neurotoxicology, 2011, Volume: 32, Issue:4

    Topics: Animals; Behavior, Animal; Biomarkers; Brain; Cell Phone; Disease Models, Animal; Electromagnetic Radiation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Neurotoxicity Syndromes; Picrotoxin; Proto-Oncogene Proteins c-fos; Radiation Injuries; Rats; Rats, Sprague-Dawley; Seizures; Time Factors

2011
Carbamazepine inhibits distinct chemoconvulsant-induced seizure-like activity in Dugesia tigrina.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:4

    Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Antagonists; N-Methylaspartate; Nicotine; Nicotinic Agonists; Oxcarbazepine; Picrotoxin; Planarians; Seizures; Structure-Activity Relationship

2011
TASK Channel Deletion Reduces Sensitivity to Local Anesthetic-induced Seizures.
    Anesthesiology, 2011, Volume: 115, Issue:5

    Topics: Anesthetics, Local; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Electroencephalography; Humans; Hydrogen-Ion Concentration; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Picrotoxin; Potassium Channels, Tandem Pore Domain; Seizures

2011
Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders.
    Journal of ethnopharmacology, 2011, Dec-08, Volume: 138, Issue:3

    Topics: Acanthaceae; Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Female; Male; Medicine, African Traditional; Methanol; Mice; Nigeria; Phenobarbital; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures; Solvents; Strychnine

2011
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
    Epilepsy & behavior : E&B, 2011, Volume: 22, Issue:4

    Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Compounding; Drug Interactions; Epilepsy; Gas Chromatography-Mass Spectrometry; Lipid Peroxidation; Male; Manihot; Motor Activity; Muscarinic Agonists; Pentylenetetrazole; Phytotherapy; Picrotoxin; Pilocarpine; Plant Preparations; Random Allocation; Rats; Rats, Wistar; Seizures; Superoxide Dismutase

2011
Human intravenous immunoglobulins suppress seizure activities and inhibit the activation of GFAP-positive astrocytes in the hippocampus of picrotoxin-kindled rats.
    The International journal of neuroscience, 2012, Volume: 122, Issue:4

    Topics: Animals; Astrocytes; CA1 Region, Hippocampal; CA2 Region, Hippocampal; Convulsants; Dentate Gyrus; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Immunoglobulins, Intravenous; Kindling, Neurologic; Male; Picrotoxin; Rats; Rats, Wistar; Seizures

2012
Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed.
    Bioscience, biotechnology, and biochemistry, 2012, Volume: 76, Issue:1

    Topics: Animals; Anticonvulsants; Benzodiazepines; Central Nervous System; Central Nervous System Agents; Enzymes; Male; Mice; Phaeophyceae; Picrotoxin; Plant Extracts; Plants, Edible; Rats; Receptors, GABA-A; Seaweed; Seizures; Sleep; Tannins

2012
Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:2

    Topics: Animals; Astrocytes; Bridged-Ring Compounds; Calcium-Binding Proteins; Cerebral Cortex; Convulsants; Extremities; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Male; Mice; Microfilament Proteins; Microglia; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures

2012
UPLC-TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities.
    Journal of ethnopharmacology, 2012, May-07, Volume: 141, Issue:1

    Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ethanol; Female; Galium; Male; Mice; Motor Activity; Neuroprotective Agents; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Reaction Time; Seizures; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors

2012
Activity-dependent alternative splicing increases persistent sodium current and promotes seizure.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, May-23, Volume: 32, Issue:21

    Topics: Alternative Splicing; Animals; Drosophila Proteins; Exons; gamma-Aminobutyric Acid; Membrane Potentials; Molecular Sequence Data; Mutant Proteins; Phenytoin; Picrotoxin; Ribonucleoproteins; Seizures; Sodium Channels; Synaptic Transmission

2012
Combination of valproate and paroxetine in mice exposed to picrotoxin.
    International journal of nanomedicine, 2012, Volume: 7

    Topics: Animals; Anticonvulsants; Brain Chemistry; Drug Combinations; gamma-Aminobutyric Acid; Mice; Nucleus Accumbens; Paroxetine; Picrotoxin; Seizures; Selective Serotonin Reuptake Inhibitors; Thiobarbituric Acid Reactive Substances; Valproic Acid

2012
Synthesis of some azoles incorporating a sulfonamide moiety as anticonvulsant agents.
    Archiv der Pharmazie, 2012, Volume: 345, Issue:9

    Topics: Animals; Anticonvulsants; Azoles; Convulsants; Drug Design; Mice; Molecular Structure; Picrotoxin; Seizures; Structure-Activity Relationship; Sulfonamides; Survival Analysis

2012
Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana.
    Phytotherapy research : PTR, 2002, Volume: 16, Issue:3

    Topics: Animals; Anticonvulsants; Convulsants; Disaccharides; Flavonoids; Flavonols; Glycosides; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Motor Activity; Orchidaceae; Pentobarbital; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Sprague-Dawley; Seizures; Sleep Wake Disorders

2002
Evidence for an involvement of nitric oxide and gamma aminobutyric acid in the anticonvulsant action of L-arginine on picrotoxin-induced convulsions in rats.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:3

    Topics: Animals; Anticonvulsants; Arginine; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Nitric Oxide; Picrotoxin; Rats; Rats, Wistar; Seizures

2002
Possible anxiolytic effects of ivermectin in rats.
    Veterinary research communications, 2002, Volume: 26, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Ivermectin; Locomotion; Male; Picrotoxin; Rats; Rats, Wistar; Seizures

2002
An anticonvulsant profile of the ketogenic diet in the rat.
    Epilepsy research, 2002, Volume: 50, Issue:3

    Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Bicuculline; Convulsants; Dietary Fats; Disease Models, Animal; Electroencephalography; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Strychnine; Survival Rate; Time Factors

2002
Interaction of stress and noradrenergic drugs in the control of picrotoxin-induced seizures.
    Epilepsy research, 2002, Volume: 51, Issue:1-2

    Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Analysis of Variance; Animals; Benzylamines; Desipramine; Drug Interactions; Enzyme Inhibitors; GABA Antagonists; Male; Mice; Mice, Inbred CBA; Picrotoxin; Seizures; Stress, Physiological; Swimming

2002
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
    Journal of ethnopharmacology, 2002, Volume: 83, Issue:1-2

    Topics: Animals; Anticonvulsants; Benzopyrans; Bicuculline; Cassia; Diazepam; Dopamine; Dose-Response Relationship, Drug; Male; Maze Learning; Methamphetamine; Pentylenetetrazole; Phenalenes; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Seizures; Sleep; Strychnine; Thiopental

2002
Sex difference in susceptibility to picrotoxin-induced seizures in rats following octreotide.
    The International journal of neuroscience, 2002, Volume: 112, Issue:8

    Topics: Animals; Disease Susceptibility; Estrous Cycle; Female; Hormones; Male; Octreotide; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Sex Factors; Somatostatin

2002
The effect of N-nitro-L-arginine methyl ester posttreatment on the anticonvulsant effect of phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 74, Issue:4

    Topics: Animals; Anticonvulsants; Diazepam; Drug Synergism; Male; NG-Nitroarginine Methyl Ester; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures

2003
5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties.
    Biochemical pharmacology, 2003, Jul-01, Volume: 66, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Drugs, Chinese Herbal; Flavonoids; Ligands; Male; Maze Learning; Mice; Mice, Inbred ICR; Motor Activity; Picrotoxin; Plants, Medicinal; Psychomotor Performance; Radioligand Assay; Rats; Rats, Sprague-Dawley; Scutellaria baicalensis; Seizures

2003
Increased neuronal nitric oxide synthase (nNOS) activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic drugs.
    Brain research, 2003, Jul-25, Volume: 979, Issue:1-2

    Topics: Animals; Anticonvulsants; Brain; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indazoles; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Picrotoxin; Rats; Rats, Wistar; Seizures

2003
Prevention of picrotoxin convulsions-induced learning and memory impairment by nitric oxide increasing dose of L-arginine in rats.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:2

    Topics: Animals; Arginine; Avoidance Learning; Convulsants; Dose-Response Relationship, Drug; Electroshock; Learning Disabilities; Male; Memory Disorders; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Picrotoxin; Psychomotor Performance; Rats; Rats, Wistar; Seizures

2003
Long-term social isolation enhances picrotoxin seizure susceptibility in mice: up-regulatory role of endogenous brain allopregnanolone in GABAergic systems.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:4

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Male; Mice; Picrotoxin; Pregnanolone; Receptors, GABA-A; Seizures; Social Isolation; Time; Up-Regulation

2003
Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L.
    Pharmacological research, 2003, Volume: 48, Issue:5

    Topics: Animals; Anticonvulsants; Artemisia; Central Nervous System Agents; Convulsants; Ethanol; Gas Chromatography-Mass Spectrometry; Lethal Dose 50; Male; Mice; Oils, Volatile; Pentylenetetrazole; Picrotoxin; Pilocarpine; Plant Extracts; Plant Leaves; Postural Balance; Rats; Rats, Wistar; Seizures; Solvents; Strychnine

2003
[Comparative action of products, numbers 3277 R.P., 4560 R.P., 4909 R.P. and of phenobarbital on convulsions induced by strychnine, picrotoxin, cocaine, cafeine and amphetamine].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1956, Volume: 150, Issue:7

    Topics: Amphetamine; Amphetamines; Chlorpromazine; Cocaine; Histamine H1 Antagonists; Phenobarbital; Phenothiazines; Picrotoxin; Seizures; Strychnine

1956
Strain differences in picrotoxin seizure threshold.
    Nature, 1962, Jan-20, Volume: 193

    Topics: Learning; Picrotoxin; Seizures

1962
[Comparative studies on the convulsive action of bemegrid, pentetrazol and picrotoxin].
    Archives internationales de pharmacodynamie et de therapie, 1962, Jan-01, Volume: 135

    Topics: Central Nervous System Stimulants; Pentylenetetrazole; Picrotoxin; Seizures

1962
Circulation of cerebrospinal fluid in the spinal region of the cat.
    The Journal of physiology, 1962, Volume: 163

    Topics: Animals; Cats; Cerebrospinal Fluid; Picrotoxin; Seizures; Spinal Cord

1962
FREE AMINO ACIDS AND RELATED COMPOUNDS IN DOG BRAIN: POST-MORTEM AND ANOXIC CHANGES, EFFECTS OF AMMONIUM CHLORIDE INFUSION, AND LEVELS DURING SEIZURES INDUCED BY PICROTOXIN AND BY PENTYLENETETRAZOL.
    Journal of neurochemistry, 1963, Volume: 10

    Topics: Amino Acids; Ammonium Chloride; Autopsy; Brain; Dogs; Hypoxia; Pathology; Pentylenetetrazole; Pharmacology; Picrotoxin; Proteins; Research; Seizures

1963
[THE BIOELECTRIC ACTIVITY OF THE CENTRAL AND SYMPATHETIC NERVOUS SYSTEMS IN CAMPHOR, NICOTINE AND PICROTOXIN-INDUCED SEIZURES].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1963, Volume: 49

    Topics: Autonomic Nervous System; Camphor; Electroencephalography; Ganglia; Ganglia, Autonomic; Hypothalamus; Nicotine; Pharmacology; Picrotoxin; Rabbits; Research; Seizures; Sympathetic Nervous System; Toxicology

1963
STIMULANT ACTION OF PYRIDYL DERIVATIVES OF BENZODIOXANS AND BENZODIOXEPANS.
    International journal of neuropharmacology, 1963, Volume: 2

    Topics: Animals; Anticonvulsants; Atropine; Bemegride; Central Nervous System Agents; Central Nervous System Stimulants; Chlorisondamine; Chlorpromazine; Diazepam; Mephenesin; Meprobamate; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Phenytoin; Picrotoxin; Research; Seizures; Strychnine; Tranquilizing Agents

1963
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF PHENYL-SUBSTITUTED BIURETS.
    Journal of medicinal chemistry, 1963, Volume: 6

    Topics: Atropine; Biuret; Chemistry, Pharmaceutical; Gastric Juice; Meprobamate; Mice; Nicotine; Pentylenetetrazole; Peptic Ulcer; Pharmacology; Phenformin; Phenobarbital; Picrotoxin; Rats; Research; Seizures; Strychnine; Toxicology; Urea

1963
THE ACTION OF SODIUM 4-HYDROXYBUTYRATE ON SPINAL REFLEXES.
    British journal of pharmacology and chemotherapy, 1964, Volume: 22

    Topics: Aminobutyrates; Anesthesia; Anesthesia, Local; Anesthesiology; Animals; Blood Pressure Determination; Cats; Diaphragm; gamma-Aminobutyric Acid; Hydroxybutyrates; Injections, Intraperitoneal; Injections, Intravenous; Meprobamate; Mice; Nervous System Physiological Phenomena; Neuromuscular Junction; Pharmacology; Phrenic Nerve; Picrotoxin; Poultry; Rats; Reflex; Research; Seizures; Sodium; Sodium Oxybate; Spinal Cord; Strychnine; Swine; Toxicology

1964
THE HISTOMORPHOLOGY OF EXPERIMENTAL EXCITATION.
    Neurology, 1964, Volume: 14

    Topics: Acridines; Coloring Agents; Depression; Depressive Disorder; Hippocampus; Histology; Lysergic Acid Diethylamide; Neuroglia; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Research; Seizures; Staining and Labeling; Toxicology

1964
HISTOLOGICAL CHANGES IN STRUCTURAL CONSTITUENTS OF SPINAL MOTONEURONS AFTER PICROTOXIN, STRYCHNINE AND TETANUS TOXIN ADMINISTRATION.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Motor Neurons; Pathology; Picrotoxin; Rats; Research; Seizures; Spinal Cord; Strychnine; Tetanus Toxin; Toxicology

1964
THE DISTRIBUTION OF GAMMA-AMINOBUTYRIC ACID IN THE MONKEY BRAIN DURING PICROTOXIN-INDUCED SEIZURES.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Chromatography; gamma-Aminobutyric Acid; Glutamates; Haplorhini; Metabolism; Parietal Lobe; Picrotoxin; Research; Seizures; Toxicology

1964
CARDIAC EFFECTS OF DIMEFLINE COMPARED WITH THOSE OF OTHER CENTRAL NERVOUS SYSTEM STIMULANTS.
    Archives internationales de pharmacodynamie et de therapie, 1964, Sep-01, Volume: 151

    Topics: Aminobutyrates; Bemegride; Benzene; Calcium; Central Nervous System Stimulants; Chlorides; Coronary Vessels; Electrocardiography; Epinephrine; Flavones; Flavonoids; Guinea Pigs; Heart; Nikethamide; Pentylenetetrazole; Pharmacology; Picrotoxin; Research; Seizures; Strychnine; Toxicology; Ventricular Fibrillation

1964
EFFECTS OF DIELDRIN, PICROTOXIN AND TELODRIN ON THE METABOLISM OF AMMONIA IN BRAIN.
    The Biochemical journal, 1965, Volume: 94

    Topics: Alanine; Amino Acids; Ammonia; Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Dieldrin; Furans; Glutamic Acid; Glutamine; Lactates; Metabolism; Pharmacology; Picrotoxin; Rats; Seizures

1965
THE EFFECT OF PICROTOXIN ON MOTOR ACTIVITY AND THE ELECTROENCEPHALOGRAM OF MICE.
    British journal of pharmacology and chemotherapy, 1965, Volume: 24

    Topics: Amphetamine; Amphetamines; Animals; Bemegride; Blood Pressure; Dextroamphetamine; Electroencephalography; Electrophysiology; Injections, Intravenous; Mice; Motor Activity; Motor Neurons; Movement; Pharmacology; Picrotoxin; Research; Seizures

1965
Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1.
    Acta pharmacologica Sinica, 2003, Volume: 24, Issue:10

    Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Carrier Proteins; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; Genetic Predisposition to Disease; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Seizures

2003
Developmental characteristics of picrotoxin-induced convulsions in rats with genetic absence epilepsy.
    Experimental neurology, 2003, Volume: 184, Issue:1

    Topics: Aging; Animals; Brain; Convulsants; Electroencephalography; Epilepsy, Absence; GABA Antagonists; GABA-A Receptor Antagonists; Picrotoxin; Rats; Rats, Wistar; Seizures

2003
Demonstrating the dose- and time-related effects of 7-nitroindazole on picrotoxin-induced convulsions, memory formation, brain nitric oxide synthase activity, and nitric oxide concentration in rats.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 77, Issue:1

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Indazoles; Male; Memory; Nitric Oxide; Nitric Oxide Synthase; Picrotoxin; Rats; Rats, Wistar; Seizures; Time Factors

2004
Inhibitory effects of the essential oil from SuHeXiang Wan on the central nervous system after inhalation.
    Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:4

    Topics: 4-Aminobutyrate Transaminase; Administration, Inhalation; Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Drugs, Chinese Herbal; Glutamic Acid; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Oils, Volatile; Pentylenetetrazole; Phytotherapy; Picrotoxin; Receptors, GABA-A; Seizures; Sleep; Strychnine

2004
Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol.
    Neuroreport, 2004, Mar-01, Volume: 15, Issue:3

    Topics: Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Carbolines; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Flutamide; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Picrotoxin; Receptors, Androgen; Receptors, GABA-A; Seizures; Testosterone

2004
Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
    Indian journal of physiology and pharmacology, 2003, Volume: 47, Issue:4

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Indazoles; Male; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures

2003
Reversal of hippocampal LTP by spontaneous seizure-like activity: role of group I mGluR and cell depolarization.
    Journal of neurophysiology, 2005, Volume: 93, Issue:1

    Topics: Animals; Bicuculline; Calcium; Dendrites; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Membrane Potentials; Models, Neurological; Neurons; Picrotoxin; Receptors, Metabotropic Glutamate; Seizures; Synaptic Transmission; Time Factors

2005
Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 78, Issue:4

    Topics: Alanine; Amino Acids; Animals; Bicuculline; Convulsants; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Male; Mice; Microinjections; N-Methylaspartate; Picrotoxin; Pregnenolone; Seizures

2004
The effect of L-arginine on the memory impairing action of phenobarbitone in rats that convulsed after the injection of picrotoxin.
    Indian journal of physiology and pharmacology, 2004, Volume: 48, Issue:2

    Topics: Animals; Arginine; Male; Memory Disorders; Nitric Oxide; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures

2004
Influence of seizures on lipids of homogenate and neuronal and glial nuclei of rat neocortex.
    Biochemistry. Biokhimiia, 2004, Volume: 69, Issue:10

    Topics: Animals; Cell Nucleus; Convulsants; DNA; Lipid Metabolism; Lysophosphatidylcholines; Male; Microscopy, Electron; Neocortex; Neuroglia; Neurons; Nuclear Proteins; Picrotoxin; Rats; Seizures; Sphingomyelins

2004
Free radical lipid oxidation in brain cortex neurons and neuroglia during convulsions.
    Bulletin of experimental biology and medicine, 2004, Volume: 138, Issue:4

    Topics: Animals; Cerebral Cortex; Convulsants; Free Radicals; Lipid Peroxidation; Male; Neuroglia; Neurons; Picrotoxin; Rats; Seizures

2004
Anticonvulsant effects of acute and repeated fluoxetine treatment in unstressed and stressed mice.
    Brain research, 2005, Feb-01, Volume: 1033, Issue:1

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Fluoxetine; Hindlimb; Male; Mice; Mice, Inbred CBA; Picrotoxin; Seizures; Stress, Psychological; Swimming

2005
Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices.
    Brain research. Developmental brain research, 2005, Feb-08, Volume: 154, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Caseins; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Fetal Nutrition Disorders; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Lactation; Male; Picrotoxin; Pregnancy; Prenatal Nutritional Physiological Phenomena; Quinolinic Acid; Rats; Seizures; Time Factors; Tritium

2005
Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 80, Issue:3

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; gamma-Aminobutyric Acid; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures

2005
The effects of L-DOPA and transcranial magnetic stimulation on behavioral reactions in kindled rats.
    Neuroscience and behavioral physiology, 2005, Volume: 35, Issue:3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dopamine Agents; Electric Stimulation; Electromagnetic Fields; Epilepsy; Exploratory Behavior; Feeding Behavior; Female; Kindling, Neurologic; Levodopa; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Sexual Behavior, Animal

2005
Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures.
    Neurochemical research, 2005, Volume: 30, Issue:5

    Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hippocampus; Male; Microdialysis; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures

2005
Abolition of spindle oscillations and 3-Hz absence seizurelike activity in the thalamus by using high-frequency stimulation: potential mechanism of action.
    Journal of neurosurgery, 2005, Volume: 103, Issue:3

    Topics: Action Potentials; Animals; Deep Brain Stimulation; Epilepsy; Essential Tremor; Female; Ferrets; GABA Antagonists; Male; Neurons; Neurotransmitter Agents; Parkinson Disease; Periodicity; Picrotoxin; Seizures; Synaptic Membranes; Thalamus

2005
Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 82, Issue:3

    Topics: Animals; Behavior, Animal; Benzodiazepines; Carbolines; Convulsants; Dose-Response Relationship, Drug; Male; Picrotoxin; Rats; Rats, Wistar; Seizures

2005
Stimulation of 5-HT 1A receptors increases the seizure threshold for picrotoxin in mice.
    European journal of pharmacology, 2005, Dec-19, Volume: 527, Issue:1-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Drug Administration Schedule; Drug Therapy, Combination; Ketanserin; Male; Mice; Mice, Inbred CBA; Picrotoxin; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Seizures; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Stress, Physiological; Swimming

2005
Picrotoxin-induced convulsions alters rat brain microsomal membrane structural properties.
    Neuroscience letters, 2006, Feb-06, Volume: 394, Issue:1

    Topics: Animals; Brain; Cholesterol; Disease Models, Animal; Male; Membranes; Microsomes; Phospholipids; Picrotoxin; Rats; Seizures

2006
Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice.
    Phytotherapy research : PTR, 2005, Volume: 19, Issue:12

    Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Bicuculline; Female; Fruit; Hot Temperature; Male; Mice; Mice, Inbred BALB C; Pain; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures; Tetrapleura

2005
GSM radiation triggers seizures and increases cerebral c-Fos positivity in rats pretreated with subconvulsive doses of picrotoxin.
    Neuroscience letters, 2006, May-01, Volume: 398, Issue:1-2

    Topics: Animals; Brain; Cell Phone; Convulsants; Male; Microwaves; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures

2006
Nifedipine inhibits picrotoxin-induced seizure activity: further evidence on the involvement of L-type calcium channel blockers in epilepsy.
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:2

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Convulsants; Dose-Response Relationship, Drug; Female; Nifedipine; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures

2006
Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils.
    European journal of pharmacology, 2006, May-01, Volume: 536, Issue:3

    Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Ethanol; Flumazenil; Flurothyl; GABA Antagonists; GABA-A Receptor Antagonists; Gerbillinae; Male; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid

2006
Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action.
    Indian journal of experimental biology, 2006, Volume: 44, Issue:4

    Topics: Animals; Bicuculline; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Muscimol; Picrotoxin; Seizures

2006
Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents.
    Neuroscience letters, 2006, Jul-03, Volume: 401, Issue:3

    Topics: Action Potentials; Acyclic Monoterpenes; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Mice; Monoterpenes; Neural Conduction; Pentylenetetrazole; Picrotoxin; Reaction Time; Seizures; Time Factors

2006
Seizures induced by in vivo latrunculin a and jasplakinolide microperfusion in the rat hippocampus.
    Journal of molecular neuroscience : MN, 2006, Volume: 28, Issue:2

    Topics: Actins; Animals; Anticonvulsants; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Depsipeptides; Hippocampus; Male; Microdialysis; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Thiazolidines

2006
Zimelidine decreases seizure susceptibility in stressed mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2006, Volume: 113, Issue:12

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Ketanserin; Male; Mianserin; Mice; Mice, Inbred CBA; Phenols; Picrotoxin; Piperazines; Pyridines; Seizures; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Stress, Psychological; Sulfonamides; Swimming; Zimeldine

2006
Blockade of inhibitory neurotransmission evoked seizure-like firing of cardiac parasympathetic neurons in brainstem slices of newborn rats: Implications for sudden deaths in patients of epilepsy.
    Epilepsy research, 2006, Volume: 70, Issue:2-3

    Topics: Animals; Animals, Newborn; Arrhythmias, Cardiac; Brain Stem; Cerebrospinal Fluid; Death, Sudden, Cardiac; GABA Antagonists; Glycine Agents; Neurons; Parasympathetic Nervous System; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Strychnine; Synaptic Transmission

2006
Anticonvulsant effect of Persea americana Mill (Lauraceae) (Avocado) leaf aqueous extract in mice.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:8

    Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Lethal Dose 50; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Persea; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures

2006
In vivo characterization of sedative activities of Fossilia Mastodi OSSIS.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:7

    Topics: Animals; Diazepam; Fossils; Hypnotics and Sedatives; Male; Mammals; Mice; Mice, Inbred ICR; Motor Activity; Pentobarbital; Picrotoxin; Seizures; Sleep; Tissue Extracts

2006
Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission.
    Journal of ethnopharmacology, 2007, Jan-03, Volume: 109, Issue:1

    Topics: Animals; Antidepressive Agents; Binding, Competitive; Carbon Dioxide; Central Nervous System; Cerebellum; Depression, Chemical; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Humulus; Male; Maze Learning; Motor Activity; Pentobarbital; Picrotoxin; Plant Extracts; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sleep; Solvents; Swimming; Synaptic Transmission

2007
Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats.
    Epilepsy research, 2006, Volume: 72, Issue:2-3

    Topics: Administration, Oral; Animals; Anticonvulsants; Behavior, Animal; Dibenzazepines; Disease Models, Animal; Electroencephalography; Hippocampus; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures

2006
Development of a Drosophila seizure model for in vivo high-throughput drug screening.
    The European journal of neuroscience, 2006, Volume: 24, Issue:8

    Topics: Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Cell Survival; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila; Drug Evaluation, Preclinical; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; Larva; Pentylenetetrazole; Phenotype; Phenytoin; Picrotoxin; Seizures

2006
Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.
    European journal of pharmacology, 2007, Mar-22, Volume: 559, Issue:2-3

    Topics: Analgesics; Animals; Anticonvulsants; Benzhydryl Compounds; Benzyl Compounds; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hot Temperature; Male; Mice; Molecular Structure; Motor Activity; Pain Measurement; Pain Threshold; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Receptors, Purinergic P1; Seizures; Structure-Activity Relationship; Urea

2007
Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice.
    Journal of ethnopharmacology, 2007, May-30, Volume: 112, Issue:1

    Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Crassulaceae; Dose-Response Relationship, Drug; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures

2007
Effects of postnatal caffeine exposure on seizure susceptibility in developing rats.
    Brain research, 2007, May-30, Volume: 1150

    Topics: Age Factors; Aminophylline; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Disease Susceptibility; Drug Interactions; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Severity of Illness Index

2007
Optical suppression of seizure-like activity with an LED.
    Epilepsy research, 2007, Volume: 74, Issue:2-3

    Topics: Animals; Anticonvulsants; Calcium; Cells, Cultured; Electrophysiology; Epilepsies, Partial; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Mice; Microscopy, Fluorescence; Neurons; Picrotoxin; Seizures; Ultraviolet Rays

2007
Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm ('African potato') aqueous extract in mice.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:1

    Topics: Animals; Anticonvulsants; Bicuculline; Hypoxis; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures

2008
Pro-convulsant effect of cefazolin sodium against pentylenetetrazol- or picrotoxin-induced convulsions in mice.
    Indian journal of experimental biology, 2007, Volume: 45, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Cefazolin; Convulsants; GABA-A Receptor Agonists; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures

2007
Interaction of diazepam and swim stress.
    Brain research, 2007, Dec-12, Volume: 1184

    Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Mice; Picrotoxin; Pregnanolone; Reaction Time; Seizures; Stress, Psychological; Swimming

2007
Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2008, Volume: 15, Issue:8

    Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mice; Oils, Volatile; Pentylenetetrazole; Phenytoin; Phytotherapy; Picrotoxin; Plant Leaves; Plant Oils; Poaceae; Seizures; Strychnine

2008
A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice.
    Epilepsy & behavior : E&B, 2008, Volume: 12, Issue:1

    Topics: Analysis of Variance; Animals; Anticonvulsants; Chromatography, Thin Layer; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glycine; Mice; Mice, Inbred BALB C; Phytotherapy; Picrotoxin; Plant Preparations; Seizures; Vicia faba

2008
Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin.
    Epilepsy research, 2008, Volume: 78, Issue:1

    Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, Liquid; Disease Models, Animal; Dopamine; Electroencephalography; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Methoxyhydroxyphenylglycol; Microdialysis; Picrotoxin; Pilocarpine; Rats; Rats, Wistar; Seizures; Serotonin; Statistics, Nonparametric; Time Factors

2008
Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract.
    Brain research bulletin, 2008, Jan-31, Volume: 75, Issue:1

    Topics: Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Mice; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures

2008
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
    Psychopharmacology, 2008, Volume: 197, Issue:4

    Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; Drug Interactions; Finasteride; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Oxazines; Picrotoxin; Pregnanolone; Progesterone; Receptors, GABA-A; Restraint, Physical; Seizures; Stress, Psychological

2008
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
    Neuropharmacology, 2008, Volume: 54, Issue:6

    Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; Electroshock; Enzyme Inhibitors; Epilepsy; gamma-Aminobutyric Acid; Gerbillinae; Magnesium; Male; Mice; Mice, Inbred BALB C; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution

2008
Some correlations between picrotoxin-induced seizures and gamma-aminobutyric acid in animal brain.
    The Journal of pharmacology and experimental therapeutics, 1967, Volume: 157, Issue:3

    Topics: Aminobutyrates; Animals; Diencephalon; Epinephrine; Female; In Vitro Techniques; Male; Mesencephalon; Mice; Norepinephrine; Picrotoxin; Rabbits; Seizures

1967
Delay or inhibition of convulsions by intraperitoneal injections of diverse substances.
    Canadian journal of physiology and pharmacology, 1967, Volume: 45, Issue:5

    Topics: Alanine; Aminobutyrates; Animals; Atmospheric Pressure; Brain Chemistry; Hypertonic Solutions; Injections, Intraperitoneal; Male; Organ Size; Oxygen; Pentylenetetrazole; Picrotoxin; Potassium; Rats; Seizures; Sodium; Sodium Chloride; Strychnine; Succinates; Sucrose; Urea

1967
Effect of anticonvulsants on picrotoxin induced flaccid stationary posture in mice.
    Indian journal of medical sciences, 1967, Volume: 21, Issue:6

    Topics: Animals; Anticonvulsants; Female; Mice; Picrotoxin; Seizures

1967
Inhibition of seizures induced by picrotoxin and electroshock by cholecystokinin octapeptides and their fragments in rats after intracerebroventricular administration.
    Neuropharmacology, 1984, Volume: 23, Issue:8

    Topics: Animals; Anticonvulsants; Diazepam; Electroshock; Injections, Intraventricular; Male; Peptide Fragments; Picrotoxin; Rats; Seizures; Sincalide

1984
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
    British journal of pharmacology, 1984, Volume: 83, Issue:2

    Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Tolerance; Isoquinolines; Ligands; Male; Mice; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Strychnine

1984
Interaction between delta-9-tetrahydrocannabinol and kindling by electrical and chemical stimuli in mice.
    Neuropharmacology, 1984, Volume: 23, Issue:11

    Topics: Animals; Dronabinol; Drug Interactions; Electric Stimulation; Electroshock; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Stimulation, Chemical; Time Factors

1984
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
    Brain research, 1980, May-12, Volume: 189, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stress, Physiological; Thiosemicarbazones

1980
Effect of repeated electroconvulsive shocks (ECS) on subthreshold doses of some CNS stimulants.
    Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 246, Issue:1

    Topics: Animals; Central Nervous System Stimulants; Electroshock; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures

1980
Dihydropicrotoxinin binding sites in mammalian brain: interaction with convulsant and depressant benzodiazepines.
    Brain research, 1981, Jul-20, Volume: 216, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Brain; gamma-Aminobutyric Acid; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures; Stereoisomerism

1981
Behavior during hippocampal microinfusions. IV. Transmitter interactions.
    Brain research, 1982, Volume: 257, Issue:1

    Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Exploratory Behavior; gamma-Aminobutyric Acid; Hippocampus; Male; Motor Activity; Neurotransmitter Agents; Norepinephrine; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1982
Dose-dependence of the effect of hydralazine on the central nervous system in rats.
    The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:1

    Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Hydralazine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors

1983
Modification of seizures elicited by the benzodiazepine Ro 5-3663--a comparison with picrotoxin.
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:12

    Topics: Animals; Benzodiazepinones; Chemical Phenomena; Chemistry; Convulsants; Diazepam; Drug Synergism; Flumazenil; Male; Mice; Picrotoxin; Pyrazoles; Quinolines; Seizures

1984
Halothane effect on cGMP and control of motor activity in mouse cerebellum.
    Anesthesiology, 1981, Volume: 54, Issue:3

    Topics: Animals; Cerebellum; Cyclic GMP; Halothane; Isoniazid; Male; Mice; Motor Activity; Picrotoxin; Seizures; Strychnine

1981
Interactions between cholinergic drugs, gamma-aminobutyric acid and cyclic guanosine monophosphate on picrotoxin-induced convulsive-seizure threshold.
    Neuropharmacology, 1981, Volume: 20, Issue:9

    Topics: Animals; Cyclic GMP; Dibutyryl Cyclic GMP; Drug Interactions; gamma-Aminobutyric Acid; Mice; Oxotremorine; Parasympathomimetics; Picrotoxin; Seizures

1981
Specific proconvulsant action of an imidazobenzodiazepine (RO 15-1788) on isoniazid convulsions.
    Neuropharmacology, 1982, Volume: 21, Issue:1

    Topics: Animals; Benzodiazepinones; Brain; Convulsants; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; Isoniazid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Seizures

1982
Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling).
    Psychopharmacology, 1982, Volume: 76, Issue:1

    Topics: Animals; Bicuculline; Electroshock; GABA Antagonists; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures

1982
Antagonism of GABA-mediated responses by d-tubocurarine in hippocampal neurons.
    Journal of neurophysiology, 1982, Volume: 48, Issue:3

    Topics: Animals; Bicuculline; Culture Techniques; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Neural Inhibition; Neurons; Picrotoxin; Receptors, Adrenergic, beta; Seizures; Synapses; Synaptic Transmission; Tetrodotoxin; Tubocurarine

1982
Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes.
    Psychopharmacology, 1982, Volume: 78, Issue:1

    Topics: Animals; Behavior, Animal; Bicuculline; Body Temperature Regulation; Dose-Response Relationship, Drug; Ethanol; Female; Motor Activity; Muridae; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Sleep Stages; Strychnine

1982
Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments.
    Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 322, Issue:3

    Topics: 3-Mercaptopropionic Acid; Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Brain; Cell Compartmentation; Cell Fractionation; Cerebellum; Drug Interactions; Female; gamma-Aminobutyric Acid; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Synaptosomes

1983
Structure-activity and dose-effect relationships of the antagonism of picrotoxin-induced seizures by cholecystokinin, fragments and analogues of cholecystokinin in mice.
    Neuropharmacology, 1983, Volume: 22, Issue:10

    Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Male; Mice; Peptide Fragments; Picrotoxin; Seizures; Sincalide; Structure-Activity Relationship

1983
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
    European journal of pharmacology, 1983, Oct-28, Volume: 94, Issue:3-4

    Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures

1983
Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures.
    Journal of neural transmission, 1983, Volume: 58, Issue:3-4

    Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Convulsants; Dose-Response Relationship, Drug; Flumazenil; Lorazepam; Male; Muridae; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures

1983
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
    Psychopharmacology, 1984, Volume: 82, Issue:3

    Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures

1984
Proconvulsant action of CGS 8216.
    Neuroscience letters, 1983, Mar-14, Volume: 35, Issue:3

    Topics: Animals; Benzodiazepinones; Convulsants; Drug Synergism; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrazoles; Seizures

1983
Effect of dihydroergotoxine on the susceptibility of rats to convulsions produced by different convulsant agents.
    Psychopharmacology, 1983, Volume: 80, Issue:2

    Topics: Animals; Bicuculline; Convulsants; Dihydroergotoxine; Drug Synergism; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Strychnine

1983
Facilitation of diazepam action by anticonvulsant agents against picrotoxin induced convulsions.
    Psychopharmacology, 1983, Volume: 81, Issue:4

    Topics: Animals; Anticonvulsants; Diazepam; Female; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1983
Effect of prostaglandin synthetase inhibitors on experimentally induced convulsions in rats.
    Pharmacology, 1984, Volume: 29, Issue:2

    Topics: Animals; Anticonvulsants; Bicuculline; Cyclooxygenase Inhibitors; Electroshock; Female; Hindlimb; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1984
Differential effects of picrotoxin- and pentylenetetrazol-induced convulsions on the secretion of luteinizing hormone and follicle-stimulating hormone in rats.
    Psychoneuroendocrinology, 1984, Volume: 9, Issue:4

    Topics: Animals; Calcium; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Male; Pentylenetetrazole; Picrotoxin; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Seizures

1984
[Effect of nootropic agents on the lowering of the spasm threshold after a single ethanol application].
    Biomedica biochimica acta, 1984, Volume: 43, Issue:10

    Topics: Animals; Brain; Ethanol; Male; Meclofenoxate; Meglumine; Mice; Orotic Acid; Picrotoxin; Piracetam; Pyrithioxin; Seizures; Spasm; Time Factors

1984
[Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1981, Volume: 175, Issue:1

    Topics: Animals; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Valproic Acid

1981
Increased sensitivity to picrotoxin as an index of physical dependence on alcohol in the mouse.
    Drug and alcohol dependence, 1984, Volume: 14, Issue:2

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Dose-Response Relationship, Drug; Humans; Lethal Dose 50; Male; Mice; Picrotoxin; Psychoses, Alcoholic; Pyrazoles; Reaction Time; Seizures

1984
Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate.
    Neuropharmacology, 1984, Volume: 23, Issue:9

    Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1984
Functional anatomy of limbic seizures: focal discharges from medial entorhinal cortex in rat.
    Brain research, 1983, Nov-28, Volume: 280, Issue:1

    Topics: Animals; Autoradiography; Carbon Radioisotopes; Deoxyglucose; Electric Stimulation; Hippocampus; Male; Penicillins; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Temporal Lobe

1983
Morphine potentiates seizures induced by GABA antagonists and attenuates seizures induced by electroshock in the rat.
    European journal of pharmacology, 1983, Nov-25, Volume: 95, Issue:3-4

    Topics: Animals; Bicuculline; Drug Synergism; Electroshock; GABA Antagonists; Isoniazid; Male; Morphine; Naloxone; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1983
Effect of phenoxybenzamine on the GABA system and on convulsive activity.
    Neuropsychobiology, 1983, Volume: 10, Issue:1

    Topics: Aminooxyacetic Acid; Animals; Behavior, Animal; Brain Chemistry; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Phenoxybenzamine; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Tissue Distribution

1983
Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:8

    Topics: Animals; Anticonvulsants; Electroencephalography; Electroshock; Female; Imidazoles; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Procaine; Rabbits; Rats; Rats, Inbred Strains; Seizures; Species Specificity

1983
Interactions of two phenylquinolines with picrotoxin and benzodiazepines in vivo and in vitro.
    European journal of pharmacology, 1984, Jan-27, Volume: 97, Issue:3-4

    Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Myoclonus; Pentylenetetrazole; Picrotoxin; Quinolines; Rats; Rats, Inbred Strains; Seizures

1984
Effects of intracellular injections of chloride and EGTA on postepileptiform-burst hyperpolarizations in hippocampal neurons.
    Neuroscience letters, 1981, Mar-10, Volume: 22, Issue:2

    Topics: Animals; Chlorides; Egtazic Acid; Ethylene Glycols; Guinea Pigs; Hippocampus; Neurons; Penicillins; Picrotoxin; Seizures

1981
Convulsant-specific architecture of the postictal behavior syndrome in the rat.
    Epilepsia, 1981, Volume: 22, Issue:5

    Topics: Animals; Behavior, Animal; Benzodiazepinones; Catatonia; Convulsants; Disease Models, Animal; Electroshock; Epilepsy, Tonic-Clonic; Female; Humans; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures

1981
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.
    Neuropharmacology, 1982, Volume: 21, Issue:2

    Topics: Acoustic Stimulation; Aggression; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; Humans; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid

1982
Pharmacological investigation of convulsant gamma-aminobutyric acid (GABA) antagonists in amygdala-kindled rats.
    Epilepsia, 1982, Volume: 23, Issue:2

    Topics: Amygdala; Animals; Convulsants; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1982
Further characterization of the behavioral despair test in mice: positive effects of convulsants.
    Physiology & behavior, 1982, Volume: 28, Issue:2

    Topics: Animals; Antidepressive Agents; Bicuculline; Brain; Convulsants; Dextroamphetamine; Escape Reaction; Male; Mice; Motivation; Motor Activity; Muridae; Picrotoxin; Seizures; Sleep, REM; Strychnine

1982
Anticonvulsant effects of muscimol.
    Neurology, 1980, Volume: 30, Issue:6

    Topics: Animals; Bicuculline; GABA Antagonists; Muscimol; Neurons; Oxazoles; Penicillins; Picrotoxin; Rats; Receptors, Drug; Seizures; Strychnine

1980
Muscimol-induced myoclonic jerks in mice.
    Neuropharmacology, 1981, Volume: 20, Issue:5

    Topics: Animals; Drug Interactions; Kinetics; Male; Mice; Muscimol; Oxazoles; Picrotoxin; Seizures

1981
Behavioural effects of GABA-agonists and antagonists infused in the mesencephalic reticular formation - deep layers of superior colliculus.
    Brain research, 1981, Nov-09, Volume: 224, Issue:1

    Topics: Animals; Behavior, Animal; Bicuculline; Dominance, Cerebral; gamma-Aminobutyric Acid; Mesencephalon; Motor Activity; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Reticular Formation; Seizures; Superior Colliculi

1981
Pharmacologic analysis of the postictal immobility syndrome in the rat.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:1

    Topics: Animals; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Female; Haloperidol; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors

1981
Dihydroergotoxine and the Seizure Threshold.
    International pharmacopsychiatry, 1981, Volume: 16, Issue:1

    Topics: Allylglycine; Animals; Brain Chemistry; Catecholamines; Dihydroergotoxine; Drug Interactions; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1981
Pharmacological investigation of gamma aminobutyric acid (GABA) and the development of amygdala-kindled seizures in the rat.
    Experimental neurology, 1981, Volume: 74, Issue:3

    Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Aminocaproates; Amygdala; Animals; Bicuculline; gamma-Aminobutyric Acid; Imidazoles; Kindling, Neurologic; Male; Pentobarbital; Picrotoxin; Rats; Seizures; Vigabatrin

1981
Amygdaloid kindling and the GABA system.
    Epilepsia, 1980, Volume: 21, Issue:2

    Topics: 4-Aminobutyrate Transaminase; Amygdala; Animals; Electric Stimulation; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Seizures; Transaminases

1980
Picrotoxin convulsions involve synaptic and nonsynaptic mechanisms on cultured mouse spinal neurons.
    Science (New York, N.Y.), 1980, May-30, Volume: 208, Issue:4447

    Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Magnesium; Membrane Potentials; Mice; Picrotoxin; Seizures; Spinal Cord; Synapses

1980
Effects of anticonvulsants and glutamate antagonists on the convulsive action of kainic acid.
    Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 243, Issue:1

    Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bemegride; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrrolidines; Seizures

1980
Locomotor and convulsive responses to picrotoxin in amygdala-kindled rats.
    Experimental neurology, 1980, Volume: 70, Issue:1

    Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Electric Stimulation; gamma-Aminobutyric Acid; Locomotion; Male; Picrotoxin; Rats; Seizures

1980
Effects of barbital or diazepam withdrawal on seizure thresholds to bicuculline, picrotoxin and flurazepam.
    Proceedings of the Western Pharmacology Society, 1995, Volume: 38

    Topics: Animals; Barbital; Bicuculline; Convulsants; Diazepam; Flurazepam; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome

1995
Distribution of Fos-positive neurons in cortical and subcortical structures after picrotoxin-induced convulsions varies with seizure type.
    Brain research, 1995, Jun-12, Volume: 683, Issue:1

    Topics: Animals; Behavior, Animal; Cell Count; Cerebral Cortex; Coloring Agents; Electroencephalography; Immunohistochemistry; Infusions, Intravenous; Male; Neurons; Pentobarbital; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures

1995
[The effect of the intranigral use of the delta sleep-inducing peptide and its analogs on the motor and seizure activities of rats].
    Fiziologicheskii zhurnal imeni I.M. Sechenova, 1995, Volume: 81, Issue:2

    Topics: Animals; Anticonvulsants; Delta Sleep-Inducing Peptide; Drug Evaluation, Preclinical; Male; Microinjections; Motor Activity; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Substantia Nigra

1995
Effects of propofol and thiopentone on picrotoxin convulsive threshold in the rabbit.
    Canadian journal of physiology and pharmacology, 1995, Volume: 73, Issue:6

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Picrotoxin; Propofol; Rabbits; Seizures; Thiopental

1995
2,3-Butanedione monoxime protects mice against the convulsant effect of picrotoxin by facilitating GABA-activated currents.
    Brain research, 1995, Apr-24, Volume: 678, Issue:1-2

    Topics: Animals; Anticonvulsants; Cholinesterase Reactivators; Diacetyl; Dose-Response Relationship, Drug; Hypothalamus; Male; Mice; Picrotoxin; Receptors, GABA; Seizures

1995
Seizure-protecting effects of kyotorphin and related peptides in an animal model of epilepsy.
    Brain research bulletin, 1995, Volume: 37, Issue:3

    Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Endorphins; Hippocampus; Injections; Injections, Intraventricular; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Stereoisomerism; Substantia Nigra

1995
Neonatal caffeine exposure and seizure susceptibility in adult rats.
    Epilepsia, 1995, Volume: 36, Issue:8

    Topics: Animals; Animals, Newborn; Bicuculline; Brain; Caffeine; Female; Kainic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Receptors, Purinergic P1; Seizures; Sex Factors; Strychnine

1995
Central nervous system activity of Rhazya stricta (Decne) in mice.
    Clinical and experimental pharmacology & physiology, 1995, Volume: 22, Issue:4

    Topics: Abdomen; Analgesia; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Cimetidine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Hypnotics and Sedatives; Male; Medicine, Arabic; Mice; Motor Activity; Naloxone; Pentobarbital; Picrotoxin; Plant Extracts; Plant Leaves; Plants, Medicinal; Seizures; Sleep; Tail

1995
Effects of 1-amino-5-bromouracil on the benzodiazepine-GABAA receptor complex.
    European journal of pharmacology, 1994, Dec-12, Volume: 271, Issue:1

    Topics: Anesthesia; Animals; Anti-Anxiety Agents; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bromouracil; Convulsants; Dehydroepiandrosterone; Male; Mice; Mice, Inbred ICR; Muscimol; Picrotoxin; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Seizures; Synaptic Membranes

1994
Evolution of afterdischarge and seizure characteristics during electrical kindling of the guinea-pig.
    Brain research, 1995, Feb-20, Volume: 672, Issue:1-2

    Topics: Animals; Behavior, Animal; Electric Stimulation; Electroencephalography; Electrophysiology; Female; Guinea Pigs; Kindling, Neurologic; Male; Movement; Neural Inhibition; Picrotoxin; Reserpine; Seizures; Time Factors

1995
[Involvement of GABAergic and NMDA systems in drug-induced convulsions in mice].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1995, Volume: 15, Issue:1

    Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channels; Chloride Channels; Male; Mice; Mice, Inbred Strains; Muscimol; Phenobarbital; Picrotoxin; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Seizures

1995
The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists.
    Brain research, 1994, Oct-24, Volume: 661, Issue:1-2

    Topics: Analysis of Variance; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Electroshock; Escape Reaction; Flumazenil; GABA-A Receptor Agonists; Hippocampus; Male; Picrotoxin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sesterterpenes; Stress, Psychological; Strychnine; Sulfur Radioisotopes; Tritium

1994
On the mechanism of antiepileptic peptides appearance in the cerebrospinal fluid.
    Brain research bulletin, 1994, Volume: 35, Issue:4

    Topics: Animals; Anticonvulsants; Cats; Cerebellum; Electroshock; Male; Peptides; Picrotoxin; Rats; Rats, Wistar; Seizures; Superior Colliculi

1994
Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats.
    Journal of the neurological sciences, 1994, Volume: 121, Issue:1

    Topics: Animals; Cerebral Cortex; Differential Threshold; Electroencephalography; Electronic Data Processing; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurons; Pentylenetetrazole; Picrotoxin; Pyridoxine; Rats; Rats, Sprague-Dawley; Seizures; Thalamus; Vitamin B 6 Deficiency

1994
Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice.
    Japanese journal of pharmacology, 1994, Volume: 65, Issue:2

    Topics: Administration, Oral; Animals; Anticonvulsants; Bemegride; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Electroshock; Female; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Seizures

1994
Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.
    Agents and actions, 1994, Volume: 41 Spec No

    Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Histamine Agonists; Histamine Antagonists; Histamine H1 Antagonists; Male; Mice; Mice, Neurologic Mutants; Pentylenetetrazole; Picrotoxin; Receptors, Histamine H3; Seizures

1994
[Central inhibition action of Valeriana jatamansii Jones].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1994, Volume: 19, Issue:1

    Topics: Analgesics; Animals; Anticonvulsants; Drug Synergism; Drugs, Chinese Herbal; Female; Hypnotics and Sedatives; Male; Mice; Pentobarbital; Picrotoxin; Seizures; Semicarbazides

1994
Effects of valine, leucine, isoleucine, and a balanced amino acid solution on the seizure threshold to picrotoxin in rats.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:1

    Topics: Amino Acids; Amino Acids, Branched-Chain; Animals; Injections, Intraperitoneal; Isoleucine; Leucine; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Valine

1994
Effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on convulsive seizures.
    Methods and findings in experimental and clinical pharmacology, 1994, Volume: 16, Issue:3

    Topics: Animals; Anticonvulsants; Bicuculline; Endothelins; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine

1994
A technique for quantitative measurement of clonic convulsions in rats.
    Indian journal of physiology and pharmacology, 1994, Volume: 38, Issue:2

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Monitoring, Physiologic; Picrotoxin; Rats; Rats, Wistar; Seizures

1994
Effects of an N-methyl-D-aspartate antagonist and a GABAergic antagonist on entorhinal tetanic responses during the early stages of amygdala kindling in rats.
    Neuroscience research, 1994, Volume: 19, Issue:4

    Topics: Amygdala; Animals; Electrophysiology; GABA Antagonists; Kindling, Neurologic; Limbic System; Male; N-Methylaspartate; Picrotoxin; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures

1994
Picrotoxin-induced seizures modified by morphine and opiate antagonists.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:3

    Topics: Animals; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Male; Morphine; Motor Activity; MSH Release-Inhibiting Hormone; Narcotic Antagonists; Picrotoxin; Rats; Seizures

1993
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
    Biochemical pharmacology, 1993, Dec-14, Volume: 46, Issue:12

    Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; Mice; Muscimol; Phenobarbital; Phenytoin; Picrotoxin; Receptors, GABA; Seizures; Strychnine

1993
Behavioural and biochemical changes produced by repeated oral administration of the insecticide endosulfan in immature rats.
    Indian journal of physiology and pharmacology, 1993, Volume: 37, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Behavior, Animal; Body Weight; Eating; Endosulfan; Growth; Male; Motor Activity; Organ Size; Picrotoxin; Postural Balance; Proteins; Rats; Rats, Wistar; Seizures

1993
Picrotoxin-induced behavioral tolerance and altered susceptibility to seizures: effects of naloxone.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:3

    Topics: Animals; Behavior, Animal; Drug Tolerance; Epilepsies, Myoclonic; Epilepsies, Partial; Kindling, Neurologic; Male; Motor Activity; Naloxone; Picrotoxin; Rats; Seizures

1993
Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures.
    Brain research bulletin, 1993, Volume: 30, Issue:5-6

    Topics: Amphetamine; Animals; Antidepressive Agents; Bupropion; Desipramine; Male; Mice; N-Methylaspartate; Picrotoxin; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Zimeldine

1993
The anticonvulsant effects of propofol, diazepam, and thiopental, against picrotoxin-induced seizure in the rat.
    Middle East journal of anaesthesiology, 1993, Volume: 12, Issue:2

    Topics: Animals; Anticonvulsants; Diazepam; Female; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Seizures; Thiopental

1993
Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:4

    Topics: Animals; Anticonvulsants; Behavior, Animal; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Ethosuximide; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Seizures

1993
Behavioral effects of acute and long-term administration of catnip (Nepeta cataria) in mice.
    Veterinary and human toxicology, 1995, Volume: 37, Issue:6

    Topics: Animals; Behavior, Animal; Catalepsy; Male; Mice; Motor Activity; Pentobarbital; Picrotoxin; Plant Extracts; Plant Leaves; Plants, Medicinal; Seizures; Sleep; Stereotyped Behavior; Strychnine

1995
Frontal cortex leads other brain structures in generalised spike-and-wave spindles and seizure spikes induced by picrotoxin.
    Electroencephalography and clinical neurophysiology, 1996, Volume: 98, Issue:2

    Topics: Animals; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy, Generalized; Frontal Lobe; GABA Antagonists; Male; Mathematics; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Thalamus; Time Factors

1996
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
    Epilepsia, 1996, Volume: 37, Issue:3

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbital; Phenytoin; Picrotoxin; Rats; Rats, Wistar; Seizures

1996
Evidence disputing the link between seizure activity and high extracellular glutamate.
    Journal of neurochemistry, 1996, Volume: 66, Issue:6

    Topics: Animals; Dicarboxylic Acids; Electroencephalography; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; Membrane Potentials; Microdialysis; Neurotransmitter Uptake Inhibitors; Picrotoxin; Pyrrolidines; Rats; Rats, Sprague-Dawley; Seizures

1996
Pentobarbitone induces Fos in astrocytes: increased expression following picrotoxin and seizures.
    Experimental neurology, 1996, Volume: 139, Issue:1

    Topics: Animals; Antibody Specificity; Astrocytes; Chloride Channels; Convulsants; GABA-A Receptor Antagonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Oncogene Proteins v-fos; Pentobarbital; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures

1996
Factors determining proconvulsant and anticonvulsant effects of inhibitors of nitric oxide synthase in rodents.
    Epilepsy research, 1996, Volume: 24, Issue:2

    Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Indazoles; Kainic Acid; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Picrotoxin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Species Specificity

1996
Treatment with an antisense oligodeoxynucleotide to the GABAA receptor gamma 2 subunit increases convulsive threshold for beta-CCM, a benzodiazepine "inverse agonist', in rats.
    European journal of pharmacology, 1996, Jun-13, Volume: 306, Issue:1-3

    Topics: Analysis of Variance; Animals; Body Weight; Carbolines; Convulsants; Injections, Intraventricular; Male; Oligonucleotides, Antisense; Picrotoxin; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Seizures; Strychnine

1996
Distinct effects of N omega-nitro-L-arginine on seizures induced by several drugs in mice.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:3

    Topics: Animals; Arginine; Bicuculline; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures; Time Factors

1996
Gonadal hormones and picrotoxin-induced convulsions in male and female rats.
    Brain research, 1996, Oct-14, Volume: 736, Issue:1-2

    Topics: Analysis of Variance; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Cerebral Cortex; Estradiol; Female; Ligands; Male; Orchiectomy; Ovariectomy; Picrotoxin; Rats; Rats, Wistar; Seizures; Sex Characteristics; Testosterone

1996
Effects of NMDA antagonists on seizure thresholds induced by intrahippocampal microdialysis of picrotoxin in freely moving rats.
    Neuroscience letters, 1996, Oct-25, Volume: 218, Issue:1

    Topics: Animals; Electroencephalography; Hippocampus; Male; Microdialysis; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Sensory Thresholds

1996
Picrotoxin produces a "central" pain-like syndrome when microinjected into the somato-motor cortex of the rat.
    Physiology & behavior, 1996, Volume: 60, Issue:6

    Topics: Animals; Behavior, Animal; Male; Microinjections; Pain; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Somatosensory Cortex

1996
Fos induction in subtypes of cerebrocortical neurons following single picrotoxin-induced seizures.
    Brain research, 1996, Nov-04, Volume: 738, Issue:2

    Topics: Animals; Calcium-Binding Proteins; Cerebral Cortex; Dendrites; Immunohistochemistry; Male; Nerve Tissue Proteins; Neurons; Picrotoxin; Proto-Oncogene Proteins c-fos; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures

1996
Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice.
    Neuroreport, 1996, Nov-04, Volume: 7, Issue:15-17

    Topics: Animals; Bicuculline; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Protein-Tyrosine Kinases; Seizures

1996
Real-time spike detection in EEG signals using the wavelet transform and a dedicated digital signal processor card.
    Journal of neuroscience methods, 1996, Volume: 70, Issue:1

    Topics: Algorithms; Animals; Computer Systems; Electroencephalography; GABA Antagonists; Microcomputers; Models, Theoretical; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Signal Processing, Computer-Assisted; Software

1996
Behavioural responsiveness to picrotoxin and desipramine in adult rats prenatally exposed to different benzodiazepine receptor agonists.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1995, Volume: 5, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Alprazolam; Animals; Behavior, Animal; Desipramine; Diazepam; Female; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Rats; Rats, Wistar; Seizures; Zolpidem

1995
A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor.
    Neuropharmacology, 1996, Volume: 35, Issue:9-10

    Topics: Allosteric Regulation; Animals; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; Dose-Response Relationship, Drug; GABA Modulators; Hypnotics and Sedatives; Male; Muscle Relaxation; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Sesterterpenes; Triazoles

1996
[The effect of picrotoxin-induced seizure activity on the cAMP-dependent phosphorylation of synapsin-I in rats].
    Fiziologicheskii zhurnal imeni I.M. Sechenova, 1996, Volume: 82, Issue:7

    Topics: Animals; Cerebral Cortex; Convulsants; Cyclic AMP; Hippocampus; Male; Phosphorus Radioisotopes; Phosphorylation; Picrotoxin; Rats; Rats, Wistar; Seizures; Synapsins; Synaptosomes

1996
[The effect of aminooxyacetic acid on the antidote activity of diazepam after exposure to GABA-lytics].
    Biulleten' eksperimental'noi biologii i meditsiny, 1994, Volume: 117, Issue:4

    Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Drug Interactions; GABA Agents; Male; Mice; Picrotoxin; Seizures

1994
Chinese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices.
    Neuroscience letters, 1997, Aug-15, Volume: 231, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Drugs, Chinese Herbal; Electroshock; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoin; Picrotoxin; Potassium; Rats; Seizures; Sesquiterpenes, Eudesmane; Terpenes

1997
Comparative in vivo and in vitro studies with the potent GABAB receptor antagonist, CGP 56999A.
    European journal of pharmacology, 1997, Aug-27, Volume: 333, Issue:2-3

    Topics: Animals; Baclofen; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; GABA-B Receptor Antagonists; In Vitro Techniques; Injections, Intraperitoneal; Male; Mice; Neurons; Pentylenetetrazole; Phosphinic Acids; Picrotoxin; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Seizures; Stereotyped Behavior

1997
[Anti-convulsion effects of choto-san and chotoko (Uncariae Uncis cam Ramlus) in mice, and identification of the active principles].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1997, Volume: 117, Issue:12

    Topics: Alkaloids; Animals; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutamic Acid; Indole Alkaloids; Indoles; Male; Mice; Mice, Inbred Strains; Picrotoxin; Seizures; Strychnine

1997
Synthesis and anticonvulsant activity of a new class of 2-[(arylalky)amino]alkanamide derivatives.
    Journal of medicinal chemistry, 1998, Feb-12, Volume: 41, Issue:4

    Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Bicuculline; Drug Design; Electroshock; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Structure; Motor Activity; Picrotoxin; Postural Balance; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship; Strychnine

1998
Laminar distribution of Fos/calcium-binding protein and Fos/neurofilament protein-labeled neurons in rat motor and sensory cortex after picrotoxin-induced seizures.
    Experimental neurology, 1998, Volume: 149, Issue:2

    Topics: Animals; Calbindin 2; Calbindins; Calcium-Binding Proteins; Cerebral Cortex; Male; Motor Cortex; Nerve Tissue Proteins; Neurofilament Proteins; Neurons; Parvalbumins; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Seizures; Somatosensory Cortex

1998
Further studies on anti- and proconvulsant effects of inhibitors of nitric oxide synthase in rodents.
    European journal of pharmacology, 1998, Feb-26, Volume: 344, Issue:1

    Topics: Animals; Anticonvulsants; Convulsants; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures

1998
Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments.
    Neuroscience letters, 1998, May-22, Volume: 248, Issue:1

    Topics: Amino Acids; Animals; Aspartic Acid; Electroencephalography; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Male; Microdialysis; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Taurine

1998
[Mechanisms of development of elevated seizure readiness during norbornene intoxication].
    Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 125, Issue:6

    Topics: Animals; Bicuculline; Chloride Channels; Convulsants; Dopamine Antagonists; GABA Agonists; GABA Antagonists; Kindling, Neurologic; Lethal Dose 50; Male; Mice; Muscarinic Agonists; Norbornanes; Picrotoxin; Receptors, GABA-A; Seizures

1998
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:1

    Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Strychnine; Time Factors; Weaning

1999
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.
    General pharmacology, 1999, Volume: 32, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Clonidine; Dextromethorphan; Drug Interactions; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ketamine; Mice; Muscimol; N-Methylaspartate; Picrotoxin; Receptors, GABA; Receptors, Glutamate; Seizures; Theophylline

1999
Picrotoxin-, kainic acid- and seizure-induced Fos in brainstem, with special reference to catecholamine cell groups.
    Neuroscience research, 1999, Volume: 33, Issue:3

    Topics: Animals; Brain Stem; Gene Expression Regulation; Genes, fos; Kainic Acid; Male; Neurons; Neurotoxins; Organ Specificity; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Stereotyped Behavior; Tyrosine 3-Monooxygenase

1999
Calpain inhibitor I retards seizure offset in the hippocampus of freely moving rats.
    Neuroscience letters, 1999, Mar-26, Volume: 263, Issue:2-3

    Topics: Animals; Cysteine Proteinase Inhibitors; Electroencephalography; Glycoproteins; Male; Perfusion; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Time Factors; Videotape Recording

1999
Involvement of nitric oxide and nitric oxide synthase activity in anticonvulsive action.
    Brain research bulletin, 1999, Mar-01, Volume: 48, Issue:4

    Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Synergism; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Picrotoxin; Rats; Rats, Wistar; Seizures

1999
Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat.
    Brain research, 1999, Jun-12, Volume: 831, Issue:1-2

    Topics: Analysis of Variance; Animals; Brain Ischemia; Convulsants; Lidocaine; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Prosencephalon; Rats; Rats, Sprague-Dawley; Seizures

1999
Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy.
    Experimental neurology, 2000, Volume: 161, Issue:2

    Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Carbolines; Convulsants; Electroencephalography; Epilepsy, Absence; Frontal Lobe; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoniazid; Kainic Acid; Limbic System; Male; Parietal Lobe; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Strychnine

2000
Roles of group II metabotropic glutamate receptors in modulation of seizure activity.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 361, Issue:3

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Brain; Bridged Bicyclo Compounds; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Electrophysiology; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures

2000
Design and synthesis of anticonvulsive agents as gamma-vinyl GABA-based potential dual acting prodrugs and their biological activities.
    Bioorganic & medicinal chemistry letters, 2000, Apr-03, Volume: 10, Issue:7

    Topics: Animals; Anticonvulsants; Bicuculline; Drug Design; Mice; Pentylenetetrazole; Picrotoxin; Prodrugs; Seizures; Vigabatrin

2000
Effects of L-arginine on picrotoxin-induced increase in brain ammonia concentrations and convulsions in rats.
    Indian journal of physiology and pharmacology, 1999, Volume: 43, Issue:4

    Topics: Ammonia; Animals; Anticonvulsants; Arginine; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Tissue Distribution

1999
Guanosine and GMP prevent seizures induced by quinolinic acid in mice.
    Brain research, 2000, May-02, Volume: 864, Issue:1

    Topics: Animals; Anticonvulsants; Central Nervous System; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine; Guanosine Monophosphate; Male; Mice; Neurons; Picrotoxin; Quinolinic Acid; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Seizures; Time Factors

2000
Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.
    Neurochemistry international, 2000, Volume: 37, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Picrotoxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures

2000
Chemical kindling and seizure susceptibility in morphine dependent rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2000, Volume: 10, Issue:6

    Topics: Animals; Caffeine; Convulsants; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Kindling, Neurologic; Male; Morphine; Morphine Dependence; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA; Receptors, Purinergic P1; Seizures

2000
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:2

    Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids

2000
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
    Brain research, 2001, Jan-05, Volume: 888, Issue:1

    Topics: Animals; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; Microdialysis; Motor Activity; Neural Inhibition; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures

2001
Beta-1 adrenoceptor antagonists potentiate the anticonvulsive effect of swim stress in mice.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:3

    Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Betaxolol; Convulsants; Male; Mice; Mice, Inbred CBA; Picrotoxin; Propanolamines; Propranolol; Receptors, Adrenergic, beta-1; Seizures; Stress, Physiological; Swimming

2000
Swim stress alters the behavioural response of mice to GABA-related and some GABA-unrelated convulsants.
    Epilepsy research, 2001, Volume: 43, Issue:2

    Topics: Animals; Behavior, Animal; Convulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Mice, Inbred CBA; Picrotoxin; Seizures; Stress, Physiological; Swimming; Temperature; Water

2001
Activation of neostriatal dopaminergic system in rats prevents toxic effects of picrotoxin administered into globus pallidus.
    Bulletin of experimental biology and medicine, 2000, Volume: 130, Issue:8

    Topics: Amphetamine; Animals; Dopamine; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Male; Motor Activity; Neostriatum; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Seizures

2000
Effect of picrotoxin-induced seizures on lipid composition of cortical tissue homogenate and its nuclear fraction in rats.
    Bulletin of experimental biology and medicine, 2000, Volume: 130, Issue:9

    Topics: Animals; Cell Nucleus; Cerebral Cortex; Convulsants; Lipid Metabolism; Male; Picrotoxin; Rats; Rats, Wistar; Seizures

2000
Effect of systemically administered nitric oxide donor, sodium nitroprusside on picrotoxin-induced convulsions in rats.
    Indian journal of physiology and pharmacology, 2001, Volume: 45, Issue:1

    Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Picrotoxin; Rats; Rats, Wistar; Seizures; Vasodilator Agents

2001
Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures.
    European journal of pharmacology, 2001, Aug-10, Volume: 425, Issue:2

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Drug Combinations; Drug Tolerance; Male; Mice; Midazolam; Muscle, Skeletal; Picrotoxin; Pregnanolone; Receptors, GABA-A; Seizures

2001
Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam.
    Neurological research, 2001, Volume: 23, Issue:6

    Topics: Ammonia; Animals; Arginine; Brain; Diazepam; Drug Interactions; Epilepsy; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hyperammonemia; Male; Neural Inhibition; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Synaptic Transmission

2001
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:9

    Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Injections, Intraventricular; Male; Mice; Pentobarbital; Picrotoxin; Pyrazines; Seizures; Sleep; Time Factors; Valproic Acid

2001
The involvement of alpha2-adrenoceptors in the anticonvulsive effect of swim stress in mice.
    Psychopharmacology, 2001, Volume: 158, Issue:1

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Antagonists; Animals; Convulsants; Dihydropyridines; GABA-A Receptor Antagonists; Idazoxan; Infusions, Intravenous; Injections, Intraperitoneal; Male; Mice; Mice, Inbred CBA; Picrotoxin; Receptors, Adrenergic, alpha-2; Seizures; Stress, Physiological; Swimming

2001
Delayed impairment of response extinction after single seizures induced by picrotoxin.
    Behavioural brain research, 2002, Jan-07, Volume: 128, Issue:1

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Convulsants; Extinction, Psychological; Habituation, Psychophysiologic; Male; Picrotoxin; Rats; Rats, Wistar; Seizures

2002
Picrotoxin-induced generalised convulsive seizure in rat: changes in regional distribution and frequency of the power of electroencephalogram rhythms.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2002, Volume: 113, Issue:4

    Topics: Animals; Brain; Convulsants; Electroencephalography; Frontal Lobe; Hindlimb; Intralaminar Thalamic Nuclei; Male; Picrotoxin; Pons; Rats; Rats, Sprague-Dawley; Seizures; Signal Processing, Computer-Assisted

2002
Anticonvulsant activity of aqueous extract of Leonotis leonurus.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2002, Volume: 9, Issue:3

    Topics: Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Lamiaceae; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures

2002
Anticonvulsive activity of Butea monosperma flowers in laboratory animals.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:4

    Topics: Animals; Anticonvulsants; Behavior, Animal; Butea; Convulsants; Dyskinesia, Drug-Induced; Electroshock; Flowers; Lithium; Male; Pentylenetetrazole; Picrotoxin; Pilocarpine; Postural Balance; Rats; Rats, Sprague-Dawley; Seizures; Strychnine

2002
Antagonism of picrotoxin-induced changes in dopamine and serotonin metabolism by allopregnanolone and midazolam.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:4

    Topics: Amino Acids; Animals; Convulsants; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; Injections, Intraventricular; Male; Mice; Microinjections; Midazolam; Picrotoxin; Pregnanolone; Seizures; Serotonin

2002
The influence of neuromediators injected into nucleus caudatus on bioelectrical seizure activity of amygdala.
    Polish journal of pharmacology and pharmacy, 1976, Volume: 28, Issue:2

    Topics: Amygdala; Animals; Caudate Nucleus; Dopamine; Electrodes, Implanted; Glutamates; Injections; Male; Methacholine Compounds; Neostigmine; Neurotransmitter Agents; Picrotoxin; Rabbits; Seizures; Serotonin; Stimulation, Chemical

1976
Putative neurotransmitters in CNS and chemoconvulsions.
    Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 228, Issue:2

    Topics: Animals; Bemegride; Catecholamines; Central Nervous System; Female; Male; Mice; Neurotransmitter Agents; Pentylenetetrazole; Picrotoxin; Procaine; Seizures; Strychnine

1977
Interaction between the activity of an epileptic focus and discrete skilled movements in rats.
    Electroencephalography and clinical neurophysiology, 1975, Volume: 39, Issue:6

    Topics: Action Potentials; Animals; Forelimb; Functional Laterality; Male; Motor Cortex; Movement; Neural Inhibition; Neural Pathways; Picrotoxin; Rats; Seizures; Time Factors

1975
Functions of primary afferents and responses of extracellular K+ during spinal epileptiform seizures.
    Electroencephalography and clinical neurophysiology, 1976, Volume: 41, Issue:3

    Topics: Action Potentials; Animals; Cats; Extracellular Space; Membrane Potentials; Neural Inhibition; Neurons; Neurons, Afferent; Penicillin G; Pentobarbital; Picrotoxin; Potassium; Seizures; Spinal Cord; Spinal Nerve Roots

1976
Differential effects of cortical speading depression on epileptic foci induced by various convulsants.
    Electroencephalography and clinical neurophysiology, 1977, Volume: 43, Issue:5

    Topics: Animals; Cerebral Cortex; Convulsants; Cortical Spreading Depression; Electroencephalography; Male; Penicillin G; Pentylenetetrazole; Picrotoxin; Potassium; Rats; Seizures; Spironolactone; Strychnine

1977
Effect of p-chlorophenylalanine on the central nervous excitability threshold and on the activity of some central depressants.
    Medical biology, 1975, Volume: 53, Issue:1

    Topics: Animals; Central Nervous System; Depression, Chemical; Fenclonine; Hypnotics and Sedatives; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenylacetates; Picrotoxin; Seizures; Strychnine; Time Factors; Toluene; Urea

1975
Attempts to produce spike-and-wave complexes in the electrocorticogram of the rat.
    Epilepsia, 1975, Volume: 16, Issue:2

    Topics: Animals; Cerebral Cortex; Cobalt; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Estrogens, Conjugated (USP); Fluoroacetates; Male; Methionine Sulfoximine; Pentylenetetrazole; Picrotoxin; Rats; Seizures

1975
Effects of certain drugs connected with the system of 3',5'-cAMP on the picrotoxin convulsive-seizure threshold and on the action of GABA.
    Comptes rendus de l'Academie Bulgare des sciences : sciences mathematiques et naturelles, 1976, Volume: 29, Issue:11

    Topics: Aminobutyrates; Animals; Brain; Bucladesine; Cyclic AMP; Drug Interactions; gamma-Aminobutyric Acid; Isoproterenol; Male; Mice; Picrotoxin; Seizures

1976
Effect of isopropylnoradrenaline, adenosine, cyclic 3',5'-adenosinemonosphosphate and dibutyryl cyclic adenosinemonophosphate on the picrotoxin convulsive-seizure threshold. Interaction with gamma-aminobutyric acid.
    Acta physiologica et pharmacologica Bulgarica, 1976, Volume: 2, Issue:4

    Topics: Adenosine; Aminobutyrates; Animals; Bucladesine; Cyclic AMP; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; Norepinephrine; Picrotoxin; Seizures

1976
Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission.
    Neuropharmacology, 1979, Volume: 18, Issue:11

    Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Synaptic Transmission

1979
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
    Epilepsia, 1977, Volume: 18, Issue:4

    Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hydrazines; Male; Mice; Pentylenetetrazole; Phenelzine; Picrotoxin; Pyridoxine; Reaction Time; Seizures; Thiones; Valproic Acid

1977
Comparative effects of centrophenoxine on the picrotoxin convulsive-seizure threshold in non-irradiated and irradiated mice.
    Acta physiologica et pharmacologica Bulgarica, 1978, Volume: 4, Issue:4

    Topics: Animals; Glycolates; Injections, Intraventricular; Male; Meclofenoxate; Mice; Picrotoxin; Radiation Injuries, Experimental; Seizures; Time Factors

1978
Facilitation of bicuculline- and picrotoxin-induced seizures by sodium valproate in rats.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 239, Issue:1

    Topics: Animals; Bicuculline; Drug Synergism; Male; Picrotoxin; Rats; Seizures; Valproic Acid

1979
Involvement of central GABA-ergic systems in convulsions and aggressive behavior.
    Advances in experimental medicine and biology, 1979, Volume: 123

    Topics: 4-Aminobutyrate Transaminase; Aggression; Allylglycine; Animals; Bicuculline; Brain; Fatty Acids; gamma-Aminobutyric Acid; Humans; Kinetics; Mice; Muscimol; Picrotoxin; Rats; Seizures; Structure-Activity Relationship; Valproic Acid

1979
Effects of intracerebroventricular administration of prostaglandins E1 and E2 on chemically induced convulsions in mice.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:2

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intraventricular; Isoniazid; Male; Mice; Pentylenetetrazole; Picrotoxin; Prostaglandins E; Seizures; Strychnine

1979
Effect of tryptophol on pentylenetetrazol and picrotoxin induced convulsion in mice.
    Life sciences, 1979, May-28, Volume: 24, Issue:22

    Topics: Animals; Anticonvulsants; Brain; Indoles; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures

1979
Hypersynchronisation and sedation produced by GABA-transaminase inhibitors and picrotoxin: does GABA participate in sleep control?
    Waking and sleeping, 1979, Volume: 3, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Animals; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Seizures; Sleep Stages; Transaminases

1979
Role of dopaminergic and GABA-ergic interactions in seizure susceptibility.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 241, Issue:2

    Topics: Aminooxyacetic Acid; Animals; Apomorphine; Dopamine; Electroshock; Female; gamma-Aminobutyric Acid; Haloperidol; Male; Mice; Picrotoxin; Piribedil; Reserpine; Seizures

1979
The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.
    Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 310, Issue:1

    Topics: Animals; Brain; Diazepam; In Vitro Techniques; Male; Mice; Oxazoles; Oxygen; Pentylenetetrazole; Picrotoxin; Prostaglandins; Seizures; Thromboxanes; Time Factors; Trimethadione

1979
Comparative study of the antagonism of bemegride and picrotoxin on behavioural depressant effects of diazepam in rats and mice.
    Neuropharmacology, 1978, Volume: 17, Issue:2

    Topics: Amnesia; Animals; Behavior, Animal; Bemegride; Diazepam; Humans; Male; Mice; Motor Activity; Motor Skills; Picrotoxin; Rats; Seizures; Strychnine

1978
Comparison of effects of bicuculline, strychnine, and picrotoxin with those of pentylenetetrazol on photically evoked afterdischarges.
    Epilepsia, 1977, Volume: 18, Issue:4

    Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Electroencephalography; Isoquinolines; Light; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Visual Cortex

1977
Effect of four convulsants on the time course of presynaptic inhibition and the relation to seizure activity.
    Neuropharmacology, 1977, Volume: 16, Issue:11

    Topics: Animals; Bemegride; Bicuculline; Cerebral Cortex; Convulsants; Instinct; Male; Medulla Oblongata; Neural Inhibition; Pentylenetetrazole; Picrotoxin; Rats; Seizures

1977
[Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam].
    Eksperimentalna meditsina i morfologiia, 1978, Volume: 17, Issue:3

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; gamma-Aminobutyric Acid; Imidazoles; Male; Mice; Papaverine; Picrotoxin; Seizures; Theophylline; Time Factors

1978
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:2

    Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; Female; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Strychnine; Trimethadione; Valerates; Valproic Acid

1976
Antagonism of GABA-mediated inhibition in the central nervous system by caprolactam derivatives.
    Brain research, 1976, Jul-09, Volume: 110, Issue:2

    Topics: Aminobutyrates; Animals; Azepines; Brain; Caprolactam; Evoked Potentials; GABA Antagonists; Neural Inhibition; Picrotoxin; Rabbits; Seizures; Structure-Activity Relationship; Substantia Nigra

1976
Tracing the neural circuits of pecking and licking with intracerebral injection of convulsants.
    Activitas nervosa superior, 1976, Volume: 18, Issue:1-2

    Topics: Animals; Brain; Brain Mapping; Columbidae; Feeding Behavior; Models, Neurological; Neural Pathways; Picrotoxin; Rats; Seizures

1976
Retention disruption following post-trial picrotoxin injection into the substantia nigra.
    Brain research, 1976, Sep-03, Volume: 113, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Memory; Picrotoxin; Rats; Reaction Time; Retention, Psychology; Seizures; Strychnine; Substantia Nigra

1976
Electroencephalographic correlates of the audiogenic seizure response of inbred mice.
    Physiology & behavior, 1976, Volume: 16, Issue:5

    Topics: Acoustic Stimulation; Animals; Brain Stem; Cerebral Cortex; Female; Genetics, Behavioral; Male; Mice; Mice, Inbred Strains; Phenotype; Picrotoxin; Seizures

1976
Changes in regional brain acetylcholine levels during drug-induced convulsions.
    European journal of pharmacology, 1976, Volume: 40, Issue:2

    Topics: Acetylcholine; Animals; Bicuculline; Brain Chemistry; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine

1976
Effects of apomorphine, pimoside, theophylline, meta-tolylcarbamide and diazepam on the picrotoxin convulsive-seizure threshold.
    Comptes rendus de l'Academie Bulgare des sciences : sciences mathematiques et naturelles, 1976, Volume: 29, Issue:11

    Topics: Animals; Apomorphine; Brain; Diazepam; Male; Mice; Phenylurea Compounds; Picrotoxin; Pimozide; Seizures; Theophylline

1976
Are the central dopaminergic synapses related to the convulsive-seizure threshold?--Effects of central dopaminergic drugs on the picrotoxin convulsive-seizure threshold. Interaction with diazepam, meta-tolylcarbamide and theophylline.
    Acta physiologica et pharmacologica Bulgarica, 1976, Volume: 2, Issue:4

    Topics: Animals; Apomorphine; Diazepam; Drug Interactions; Male; Mice; Phenylurea Compounds; Picrotoxin; Pimozide; Receptors, Dopamine; Seizures; Theophylline

1976
Analysis of preseizure electrocorticographic changes in rats during hyperbaric oxygenation.
    Experimental neurology, 1975, Volume: 46, Issue:1

    Topics: Animals; Diagnosis, Computer-Assisted; Electroencephalography; Hyperbaric Oxygenation; Male; Oxygen; Pentylenetetrazole; Picrotoxin; Rats; Seizures

1975
Blockage of cortical spreading depression by picrotoxin foci of paroxysmal activity.
    Epilepsia, 1975, Volume: 16, Issue:1

    Topics: Animals; Brain; Cerebral Cortex; Cortical Spreading Depression; Electroencephalography; Pentylenetetrazole; Picrotoxin; Potassium; Potassium Chloride; Rats; Seizures; Tubocurarine

1975
Enhancement of picrotoxin convulsions in chicks and mice by the prior intraperitoneal injection of hypertonic GABA or mannitol.
    European journal of pharmacology, 1975, Volume: 30, Issue:2

    Topics: Aminobutyrates; Animals; Animals, Newborn; Chickens; Drug Synergism; gamma-Aminobutyric Acid; Hypertonic Solutions; Injections, Intraperitoneal; Mannitol; Mice; Mice, Inbred Strains; Picrotoxin; Seizures; Time Factors

1975
Rotational behavior induced in rats by intranigral picrotoxin.
    Brain research, 1975, May-16, Volume: 89, Issue:1

    Topics: Animals; Behavior, Animal; Brain Mapping; Dose-Response Relationship, Drug; Functional Laterality; GABA Antagonists; Injections; Male; Neural Inhibition; Neural Pathways; Picrotoxin; Rats; Rotation; Seizures; Substantia Nigra; Time Factors

1975
The anticonvulsant action of GABA-elevating agents: a re-evaluation.
    Journal of neurochemistry, 1975, Volume: 25, Issue:3

    Topics: Allyl Compounds; Aminobutyrates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hydrazines; Hydroxylamines; Hyperbaric Oxygenation; Isoniazid; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Stimulation, Chemical; Time Factors

1975
Locomotor activity and seizures induced by picrotoxin in the fastigeal nucleus of the rat.
    Experimental neurology, 1975, Volume: 49, Issue:2

    Topics: Animals; Cerebellar Nuclei; gamma-Aminobutyric Acid; Locomotion; Male; Neural Inhibition; Ouabain; Picrotoxin; Rats; Seizures

1975
Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+)MK-801 and voltage-dependent calcium channel blockers.
    Brain research, 1992, Oct-16, Volume: 593, Issue:2

    Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Convulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hexachlorocyclohexane; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nifedipine; Pentylenetetrazole; Picrotoxin; Seizures; Sesterterpenes; Species Specificity

1992
Effects of clonazepam on picrotoxin-induced convulsions.
    Physiological research, 1992, Volume: 41, Issue:2

    Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Epilepsy; Injections, Intraperitoneal; Picrotoxin; Rats; Rats, Wistar; Seizures

1992
[Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum].
    Biulleten' eksperimental'noi biologii i meditsiny, 1992, Volume: 113, Issue:1

    Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Diazepam; GABA Antagonists; Male; Muscimol; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Tritium

1992
Branched-chain amino acids increase the seizure threshold to picrotoxin in rats.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:3

    Topics: Amino Acids, Branched-Chain; Animals; Anticonvulsants; GABA-A Receptor Antagonists; Male; Picrotoxin; Rats; Rats, Wistar; Seizures

1992
[The effect of activation of the superior colliculus on the convulsive activity during picrotoxin-induced kindling].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1992, Volume: 78, Issue:7

    Topics: Animals; Bicuculline; Electroencephalography; Kindling, Neurologic; Male; Microinjections; Penicillin G; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Superior Colliculi

1992
Effects of somatostatin and anti-somatostatin serum on picrotoxin-kindled seizures.
    Neuropharmacology, 1992, Volume: 31, Issue:8

    Topics: Animals; Injections, Intraventricular; Kindling, Neurologic; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Somatostatin

1992
[The threshold lowering effects of chronic treatment with haloperidol on beta-carboline derivative-induced tonic convulsion].
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1992, Volume: 12, Issue:3

    Topics: Animals; Bicuculline; Carbolines; Drug Administration Schedule; Drug Interactions; Haloperidol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Seizures

1992
[Effects of neurotropin on seizure activity in picrotoxin kindling].
    Biulleten' eksperimental'noi biologii i meditsiny, 1992, Volume: 113, Issue:3

    Topics: Animals; Anticonvulsants; Ceruletide; Cycloheximide; Electroencephalography; Injections, Intraperitoneal; Injections, Intraventricular; Kindling, Neurologic; Male; Picrotoxin; Polysaccharides; Rats; Rats, Wistar; Seizures

1992
Neuropharmacology of amide derivatives of P-GABA.
    Indian journal of experimental biology, 1992, Volume: 30, Issue:7

    Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Brain; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Muscle Relaxation; Nervous System; Picrotoxin; Seizures

1992
Changes at cholecystokinin receptors induced by long-term treatment with diazepam and haloperidol.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1992, Volume: 2, Issue:4

    Topics: Aggression; Animals; Behavior, Animal; Ceruletide; Dextroamphetamine; Diazepam; Electroshock; Haloperidol; Male; Mice; Motor Activity; Picrotoxin; Receptors, Cholecystokinin; Seizures

1992
Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures.
    Life sciences, 1992, Volume: 51, Issue:10

    Topics: Animals; Binding Sites; Cerebral Cortex; Flunitrazepam; Hippocampus; Hyperthyroidism; Isoniazid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Triiodothyronine

1992
Altered response to GABAergic agents following electro and chemo convulsions in mice.
    Indian journal of experimental biology, 1991, Volume: 29, Issue:3

    Topics: Animals; Bicuculline; Electroshock; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures

1991
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
    European journal of pharmacology, 1991, Apr-24, Volume: 196, Issue:3

    Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Female; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A; Seizures; Strychnine; Synaptosomes

1991
[The role of the opiate mechanisms of the hippocampus and substantia nigra in the behavioral and convulsive disorders in picrotoxin-induced kindling].
    Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 111, Issue:3

    Topics: Analgesics; Animals; Behavior, Animal; Drug Interactions; Dynorphins; Enkephalin, Methionine; Hippocampus; Kindling, Neurologic; Male; Narcotics; Peptide Fragments; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Seizures; Substantia Nigra

1991
Paradoxical role of GABA in a chronic model of petit mal (absence)-like epilepsy in the rat.
    European journal of pharmacology, 1990, Jan-25, Volume: 176, Issue:1

    Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Epilepsy, Absence; GABA Antagonists; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Seizures; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

1990
Pharmacological evidence indicating a role of GABAergic systems in termination of limbic seizures.
    Epilepsy research, 1990, Volume: 7, Issue:3

    Topics: Animals; Baclofen; Bicuculline; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Ion Channels; Limbic System; Male; Membrane Proteins; Muscimol; Neural Inhibition; Picrotoxin; Rats; Seizures

1990
Toxicokinetics of Ro 5-4864, lindane and picrotoxin compared.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:2

    Topics: Animals; Behavior, Animal; Benzodiazepinones; Body Temperature; Body Weight; Convulsants; Dose-Response Relationship, Drug; Eating; Female; Hexachlorocyclohexane; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1991
Changes in limbic evoked potentials produced by the atypical benzodiazepine Ro 5-4864.
    Proceedings of the Western Pharmacology Society, 1991, Volume: 34

    Topics: Animals; Benzodiazepinones; Convulsants; Evoked Potentials; Female; Hexachlorocyclohexane; Hippocampus; Limbic System; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1991
Evidence that genetic differences in habituation and GABAergic mechanisms may be related to sensitivity to ethanol and development of ethanol tolerance in mice.
    Psychopharmacology, 1991, Volume: 105, Issue:1

    Topics: Animals; Avoidance Learning; Bicuculline; Body Temperature; Brain; Drug Tolerance; Environment; Ethanol; gamma-Aminobutyric Acid; Habituation, Psychophysiologic; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Motor Activity; Picrotoxin; Postural Balance; Seizures; Sleep; Species Specificity

1991
Influence of cerebro-spinal fluid of picrotoxin kindled rats on seizure susceptibility and locomotor activity of recipients.
    Indian journal of experimental biology, 1991, Volume: 29, Issue:8

    Topics: Animals; Cerebrospinal Fluid; Kindling, Neurologic; Locomotion; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1991
Regional and time dependent variations of low Mg2+ induced epileptiform activity in rat temporal cortex slices.
    Experimental brain research, 1991, Volume: 87, Issue:3

    Topics: Animals; Baclofen; Brain Mapping; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Magnesium; Picrotoxin; Pyramidal Tracts; Rats; Seizures; Temporal Lobe

1991
Changes in rat brain extracellular glutamate concentration during seizures induced by systemic picrotoxin or focal bicuculline injection: an in vivo dialysis study with on-line enzymatic detection.
    Epilepsy research, 1991, Volume: 9, Issue:2

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicuculline; Brain Chemistry; Cerebral Cortex; Dialysis; Electroencephalography; Electroshock; Extracellular Space; Glutamates; Hippocampus; Injections; Kainic Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1991
[Drug-induced seizures in taurine-deficient mice].
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1991, Volume: 11, Issue:4

    Topics: Amino Acids; Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine; Taurine

1991
Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 40, Issue:2

    Topics: Animals; Azides; Benzodiazepines; Carbolines; GABA Antagonists; Isoniazid; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Strychnine

1991
Effect of phenobarbital on motor seizures elicited by picrotoxin and bicuculline in rats.
    Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems, 1991, Volume: 33, Issue:3

    Topics: Animals; Bicuculline; Male; Pentylenetetrazole; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1991
A peptidase-resistant cyclic octapeptide analogue of somatostatin (SMS 201-995) modulates seizures induced by quinolinic and kainic acids differently in the rat hippocampus.
    Neuropharmacology, 1991, Volume: 30, Issue:4

    Topics: Animals; Atropine; Convulsants; Electroencephalography; Hippocampus; Kainic Acid; Male; Octreotide; Picrotoxin; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures

1991
Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:4

    Topics: 4-Butyrolactone; Alkylation; Animals; Anticonvulsants; Brain; Convulsants; Female; Ligands; Mice; Mice, Inbred Strains; Molecular Structure; Neurotoxins; Picrotoxin; Receptors, GABA-A; Seizures; Structure-Activity Relationship

1991
Castration alters susceptibility of male rats to specific seizures.
    Physiology & behavior, 1991, Volume: 49, Issue:6

    Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Estrogens; Male; Orchiectomy; Picrotoxin; Rats; Reaction Time; Seizures; Testosterone

1991
The proconvulsive activity of quinolone antibiotics in an animal model.
    Toxicology letters, 1991, Volume: 58, Issue:1

    Topics: Animals; Anti-Infective Agents; Convulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Nalidixic Acid; Oxolinic Acid; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine

1991
Croton zehntneri: possible central nervous system effects in rodents.
    Journal of ethnopharmacology, 1991, Volume: 33, Issue:3

    Topics: Animals; Anticonvulsants; Brazil; Male; Medicine, Traditional; Mice; Phenobarbital; Picrotoxin; Plant Extracts; Rats; Rats, Inbred Strains; Seizures; Strychnine

1991
Ro 5-4864, like picrotoxin, enhances EPSP-spike coupling in the freely behaving rat.
    Brain research bulletin, 1991, Volume: 27, Issue:1

    Topics: Animals; Benzodiazepinones; Convulsants; Electric Stimulation; Evoked Potentials; Female; Hippocampus; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1991
Seizure promotion and protection by D-1 and D-2 dopaminergic drugs in the mouse.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4

    Topics: Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Synergism; Ergolines; Female; Indoles; Male; Mice; Phenanthridines; Picrotoxin; Pilocarpine; Quinpirole; Seizures; Strychnine

1990
Low-level hyperbaric heliox does not affect drug-induced seizure latency in mice.
    Annals of the New York Academy of Sciences, 1991, Volume: 625

    Topics: Allylglycine; Animals; Atmospheric Pressure; Convulsants; Helium; Hyperbaric Oxygenation; Isoniazid; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Myoclonus; Picrotoxin; Seizures; Time Factors

1991
Threshold to elicit seizures by picrotoxin is lowered in pentylenetetrazol-kindled mice.
    Neuropharmacology, 1990, Volume: 29, Issue:11

    Topics: Animals; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures

1990
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:4

    Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1990
Involvement of the nigral output pathways in the inhibitory control of the substantia nigra over generalized non-convulsive seizures in the rat.
    Neuroscience, 1990, Volume: 39, Issue:2

    Topics: Animals; Brain; Dopamine; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Hydroxydopamines; Male; Muscimol; Norepinephrine; Oxidopamine; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Serotonin; Substantia Nigra

1990
NMDA antagonist properties of gamma-L-glutamyl-L-aspartate demonstrated on chemically induced seizures in mice.
    European journal of pharmacology, 1990, Aug-21, Volume: 185, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Dipeptides; Dose-Response Relationship, Drug; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Seizures

1990
Neuropharmacological actions of the superactive agonist analog D-TRP-6-LH-RH after peripheral injection into mice.
    Neuropeptides, 1990, Volume: 17, Issue:2

    Topics: Analgesia; Animals; Apomorphine; Behavior, Animal; Catalepsy; Central Nervous System; Exploratory Behavior; Gonadotropin-Releasing Hormone; Male; Mice; Pain Measurement; Picrotoxin; Seizures; Stereotyped Behavior; Triptorelin Pamoate

1990
Dual species dependent effect of dihydroergosine on the convulsions induced by GABA antagonists.
    Journal of neural transmission. General section, 1990, Volume: 79, Issue:1-2

    Topics: Animals; Antidepressive Agents; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Ergotamines; Female; Male; Mice; Mice, Inbred CBA; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Species Specificity

1990
Synchronous discharges in the rat entorhinal cortex in vitro: site of initiation and the role of excitatory amino acid receptors.
    Neuroscience, 1990, Volume: 34, Issue:3

    Topics: Action Potentials; Animals; Bicuculline; Cats; Cerebral Cortex; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures

1990
Are GABAB receptors involved in the pharmacological effects of ethanol?
    European journal of pharmacology, 1990, Jul-17, Volume: 182, Issue:3

    Topics: Animals; Baclofen; Cells, Cultured; Chlorine; Diazepam; Ethanol; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Picrotoxin; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Spinal Cord

1990
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4

    Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neurologic; Male; Picrotoxin; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Purinergic; Rolipram; Seizures; Theophylline; Xanthines

1990
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Lethal Dose 50; Male; Methaqualone; Mice; Molecular Structure; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship; Strychnine

1990
The effect of nimodipine on picrotoxin-induced seizures.
    Brain research bulletin, 1990, Volume: 24, Issue:1

    Topics: Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Male; Nimodipine; Picrotoxin; Rats; Seizures

1990
Gender difference in susceptibility to picrotoxin-induced seizures is seizure- and stimulation-dependent.
    Brain research bulletin, 1990, Volume: 24, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Picrotoxin; Rats; Reaction Time; Seizures; Sex Characteristics

1990
The GABAergic nigro-collicular pathway is not involved in the inhibitory control of audiogenic seizures in the rat.
    Neuroscience letters, 1990, Apr-06, Volume: 111, Issue:3

    Topics: Acoustic Stimulation; Animals; Male; Microinjections; Muscimol; Neural Pathways; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Superior Colliculi

1990
Effect of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole in mice.
    Journal of pharmacobio-dynamics, 1990, Volume: 13, Issue:1

    Topics: Animals; Anticonvulsants; Decanoic Acids; Fatty Acids; Lauric Acids; Male; Mice; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Pentylenetetrazole; Picrotoxin; Seizures; Stearic Acids

1990
Suppression of spontaneous generalized non-convulsive seizures in the rat by microinjection of GABA antagonists into the superior colliculus.
    Epilepsy research, 1990, Volume: 5, Issue:3

    Topics: Animals; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Male; Microinjections; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Superior Colliculi

1990
Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid- and picrotoxin-induced convulsions in rats.
    Life sciences, 1990, Volume: 46, Issue:7

    Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Ethanol; Kainic Acid; Male; N-Methylaspartate; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1990
Differential effects of gamma-hexachlorocyclohexane (lindane) on pharmacologically-induced seizures.
    Archives of toxicology, 1987, Volume: 59, Issue:6

    Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; Hexachlorocyclohexane; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures

1987
Opposite effects of different hexachlorocyclohexane (lindane) isomers on cerebellar cyclic GMP: relation of cyclic GMP accumulation to seizure activity.
    Life sciences, 1987, Oct-05, Volume: 41, Issue:14

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Cyclic GMP; Hexachlorocyclohexane; Isomerism; Male; Mice; Picrotoxin; Seizures; Strychnine

1987
CNS biochemical and pharmacological effects of the isomers of hexachlorocyclohexane (lindane) in the mouse.
    Toxicology and applied pharmacology, 1988, Mar-30, Volume: 93, Issue:1

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Drug Synergism; Hexachlorocyclohexane; Ion Channels; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures

1988
Convulsant properties of GABA antagonists and anticonvulsant properties of ethanol in selectively bred long- and short-sleep mice.
    Psychopharmacology, 1989, Volume: 98, Issue:4

    Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Ethanol; GABA Antagonists; Mice; Picrotoxin; Seizures

1989
Ultrastructural changes in granule cell somata and mossy fibers of the rat hippocampus during picrotoxin-induced convulsions.
    Cell and tissue research, 1989, Volume: 255, Issue:2

    Topics: Animals; Hippocampus; Inclusion Bodies; Male; Microscopy, Electron; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1989
Effects of picrotoxin treatment on GABAA receptor supramolecular complexes in rat brain.
    Journal of neurochemistry, 1989, Volume: 52, Issue:4

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Flunitrazepam; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tissue Distribution

1989
Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding.
    Brain research, 1989, Feb-27, Volume: 481, Issue:1

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Dose-Response Relationship, Drug; Frontal Lobe; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Muscimol; Pentobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Species Specificity; Synaptosomes

1989
Interaction between GABAergic anticonvulsants and the NMDA receptor antagonist MK 801 against MES- and picrotoxin-induced convulsions in rats.
    Life sciences, 1989, Volume: 44, Issue:18

    Topics: Animals; Anticonvulsants; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Electroshock; Ethanol; Male; Motor Activity; Pentobarbital; Phenobarbital; Phenytoin; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Stereotyped Behavior

1989
Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
    Journal of neuroscience research, 1989, Volume: 24, Issue:1

    Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Blotting, Northern; Convulsants; DNA-Binding Proteins; Electroshock; Gene Expression Regulation; Immunoblotting; Kainic Acid; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; Nucleic Acid Hybridization; Pentylenetetrazole; Picrotoxin; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Seizures; Transcription Factors

1989
A slow NMDA-mediated synaptic potential underlies seizures originating from midbrain.
    Brain research, 1989, May-08, Volume: 486, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; In Vitro Techniques; Inferior Colliculi; N-Methylaspartate; Picrotoxin; Rats; Seizures; Valine

1989
Changes in the activity of glutamate related enzymes in cerebral cortex, during insulin-induced seizures.
    The International journal of neuroscience, 1989, Volume: 44, Issue:1-2

    Topics: Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Blood Glucose; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Insulin; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1989
Steroid hormone effects on picrotoxin-induced seizures in female and male rats.
    Brain research, 1989, Jan-09, Volume: 476, Issue:2

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Implants; Estradiol; Female; Male; Ovariectomy; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Sex Factors; Testosterone

1989
RO15-4513 but not FG-7142 reverses anticonvulsant effects of ethanol against bicuculline- and picrotoxin-induced convulsions in rats.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1

    Topics: Affinity Labels; Animals; Appetite Depressants; Azides; Benzodiazepines; Bicuculline; Carbolines; Ethanol; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1989
The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxinin.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1989, Volume: 2, Issue:2

    Topics: Animals; Anxiety; Bicuculline; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; GABA Antagonists; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Sesterterpenes; Substance Withdrawal Syndrome

1989
Effects of the diterpene sclareol glycol on convulsive seizures.
    Methods and findings in experimental and clinical pharmacology, 1989, Volume: 11, Issue:5

    Topics: Animals; Bicuculline; Colforsin; Convulsants; Diterpenes; Drug Synergism; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures

1989
Behavioral aspects of GABAergic-dopaminergic interactions in the central nervous system.
    European journal of pharmacology, 1989, Aug-11, Volume: 167, Issue:1

    Topics: 3-Mercaptopropionic Acid; Animals; Dopamine; gamma-Aminobutyric Acid; Haloperidol; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Stereotyped Behavior; Strychnine; Time Factors

1989
[Development of motor and emotional disorders in rats during daily administration of subliminal doses of picrotoxin].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 108, Issue:7

    Topics: Animals; Behavior, Animal; Brain; Electrocardiography; Emotions; Kindling, Neurologic; Male; Movement Disorders; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Syndrome; Time Factors

1989
Behavioral and functional studies indicate a role for GABAAergic transmission in the actions of ethanol.
    Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1987, Volume: 1

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Ethanol; Flunitrazepam; Male; Mice; Mice, Inbred C57BL; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Spinal Cord

1987
Changes in benzodiazepine/GABA receptor complex function in benzodiazepine-tolerant mice.
    Psychopharmacology, 1988, Volume: 95, Issue:3

    Topics: Animals; Anticonvulsants; Bicuculline; Body Temperature; Drug Tolerance; Flurazepam; gamma-Aminobutyric Acid; Infusions, Intravenous; Male; Mice; Motor Activity; Pentobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Time Factors

1988
Picrotoxin, a gamma-aminobutyric acid-receptor antagonist, retards craniofacial development in the weaning rat: I. Effect on mandibular bone growth.
    Journal of craniofacial genetics and developmental biology, 1988, Volume: 8, Issue:4

    Topics: Alkaline Phosphatase; Animals; Body Weight; Calcium; Male; Mandible; Phosphorus; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Skull; Weaning

1988
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:4

    Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine

1988
A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:12

    Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Corpus Striatum; Dipeptides; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Picrotoxin; Quisqualic Acid; Rats; Seizures; Sodium

1985
Absence of side-effects in the anticonvulsant action of cortically applied antagonists of N-methyl-D-aspartate.
    Brain research, 1986, May-14, Volume: 373, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dipeptides; Morphine; N-Methylaspartate; Picrotoxin; Quinoxalines; Rats; Rats, Inbred Strains; Seizures; Strychnine; Valine

1986
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
    Neuropharmacology, 1986, Volume: 25, Issue:9

    Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid

1986
Effect of inferior olive lesion on seizure threshold in the rat.
    Life sciences, 1987, Jun-15, Volume: 40, Issue:24

    Topics: Animals; Bicuculline; Cerebellum; Convulsants; Male; Motor Activity; Neural Pathways; Olivary Nucleus; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Seizures; Strychnine

1987
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1

    Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Competitive; Darkness; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Structure-Activity Relationship; Tetrodotoxin

1988
Benzodiazepines increase tonic component of postdecapitation convulsions in mice.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Bicuculline; Decerebrate State; Flumazenil; Male; Mice; Mice, Inbred Strains; Picrotoxin; Receptors, GABA-A; Seizures

1988
Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:1

    Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Drug Interactions; Electroshock; Ethanol; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sleep

1985
Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA.
    European journal of pharmacology, 1985, Aug-15, Volume: 114, Issue:2

    Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Injections, Spinal; Male; Mice; Nipecotic Acids; Picrotoxin; Pipecolic Acids; Proline; Receptors, GABA-A; Seizures; Strychnine

1985
Convulsant component of a depressant benzodiazepine.
    Life sciences, 1985, Nov-18, Volume: 37, Issue:20

    Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures

1985
[Modulating effect of cerulein on benzodiazepine receptors].
    Biulleten' eksperimental'noi biologii i meditsiny, 1985, Volume: 100, Issue:12

    Topics: Animals; Brain; Ceruletide; Dose-Response Relationship, Drug; Drug Interactions; Flunitrazepam; Male; Mice; Picrotoxin; Proglumide; Reaction Time; Receptors, GABA-A; Seizures

1985
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.
    British journal of pharmacology, 1986, Volume: 87, Issue:1

    Topics: Animals; Carbachol; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Muscles; Phenobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid

1986
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
    British journal of pharmacology, 1986, Volume: 88, Issue:3

    Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; Muscimol; Pentobarbital; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Time Factors

1986
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties.
    Neuropharmacology, 1985, Volume: 24, Issue:8

    Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Electroshock; Female; Glutamate Decarboxylase; Harmaline; Male; Mice; Mice, Inbred DBA; Ouabain; Papio; Pentylenetetrazole; Picrotoxin; Rats; Riluzole; Seizures; Synaptic Transmission; Thiazoles

1985
Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:5

    Topics: Amino Acids; Amino Acids, Neutral; Animals; Anticonvulsants; Bicuculline; Electroshock; Male; Muscimol; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures

1986
Sex differences in the sensitivity of CBA mice to convulsions induced by GABA antagonists are age-dependent.
    Psychopharmacology, 1987, Volume: 91, Issue:2

    Topics: Aging; Animals; Bicuculline; Female; GABA Antagonists; Male; Mice; Mice, Inbred CBA; Picrotoxin; Seizures; Sex Factors; Strychnine

1987
Evidence for increased activity of mouse brain fatty acid cyclooxygenase following drug-induced convulsions.
    Brain research, 1987, Apr-07, Volume: 408, Issue:1-2

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Dinoprost; Dinoprostone; Ethosuximide; Female; Kinetics; Mice; Microsomes; Pentylenetetrazole; Picrotoxin; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Prostaglandins F; Seizures; Strychnine

1987
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
    Psychopharmacology, 1987, Volume: 93, Issue:3

    Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotoxin; Punishment; Seizures

1987
Post-training administration of GABAergic antagonists enhances retention of aversively motivated tasks.
    Psychopharmacology, 1988, Volume: 96, Issue:4

    Topics: Animals; Bicuculline; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Electroshock; GABA Antagonists; Male; Mice; Mice, Inbred Strains; Picrotoxin; Reinforcement, Psychology; Seizures

1988
Changes in GABA content of the brain and sensitivity to GABA-antagonists during and after repetitive treatment of rats with diphenilhydantoin.
    Folia medica, 1988, Volume: 30, Issue:3

    Topics: Animals; Brain; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1988
Suppression and induction of epileptic activity by neuronal grafts.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:23

    Topics: Animals; Denervation; Epilepsy; Hippocampus; Locus Coeruleus; Neurons; Picrotoxin; Rats; Reference Values; Seizures

1988
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
    European journal of pharmacology, 1988, Nov-22, Volume: 157, Issue:2-3

    Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures; Substance Withdrawal Syndrome

1988
Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.
    British journal of pharmacology, 1988, Volume: 93, Issue:1

    Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Bicuculline; Carbolines; Convulsants; Drug Interactions; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures

1988
Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice.
    Journal of neural transmission, 1988, Volume: 72, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Injections; Isoniazid; Mice; Osmolar Concentration; Pentylenetetrazole; Picrotoxin; Seizures; Vigabatrin

1988
GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists.
    Acta physiologica et pharmacologica Bulgarica, 1987, Volume: 13, Issue:3

    Topics: 3-Mercaptopropionic Acid; Allylglycine; Animals; Anticonvulsants; Barbiturates; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Picrotoxin; Rats; Seizures; Semicarbazides

1987
Differential effects of caffeine, picrotoxin, and pentylenetetrazol on hippocampal afterdischarge activity and wet dog shakes.
    Experimental neurology, 1987, Volume: 96, Issue:2

    Topics: Animals; Caffeine; Electroencephalography; Hippocampus; Male; Membrane Potentials; Pentylenetetrazole; Picrotoxin; Rats; Seizures

1987
Seizure activity and cortical spreading depression monitored by an extrinsic potential-sensitive molecular probe.
    Brain research, 1987, Apr-21, Volume: 409, Issue:2

    Topics: Animals; Bicuculline; Cerebral Cortex; Cortical Spreading Depression; Electrophysiology; Female; Gerbillinae; Male; Mitochondria; Picrotoxin; Potassium Chloride; Seizures

1987
Effects of neurohypophyseal peptide hormones on alcohol dependence and withdrawal.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1987, Volume: 22, Issue:1

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Lypressin; Male; Mice; Oxytocin; Picrotoxin; Psychoses, Alcoholic; Seizures

1987
Kindling by repeated intraperitoneal or intracerebral injection of picrotoxin transfers to electrical kindling.
    Experimental neurology, 1987, Volume: 97, Issue:2

    Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Injections; Injections, Intraperitoneal; Kindling, Neurologic; Male; Picrotoxin; Rats; Seizures

1987
Electrical stimulation can inhibit synchronized neuronal activity.
    Brain research, 1986, Sep-10, Volume: 382, Issue:1

    Topics: Animals; Electric Stimulation; Hippocampus; Kinetics; Neurons; Penicillins; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1986
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:3

    Topics: Animals; Anticonvulsants; Bicuculline; Electroshock; Ethosuximide; Male; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures; Valproic Acid

1985
Sex related differences in the response of mice, rats and cats to administration of picrotoxin.
    Life sciences, 1986, Mar-10, Volume: 38, Issue:10

    Topics: Animals; Cats; Dose-Response Relationship, Drug; Electrophysiology; Female; Male; Mice; Mice, Inbred CBA; Motor Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Sex Characteristics; Spinal Cord

1986
Injections of picrotoxin and bicuculline into the amygdaloid complex of the rat: an electroencephalographic, behavioural and morphological analysis.
    Neuroscience, 1985, Volume: 14, Issue:1

    Topics: Amygdala; Animals; Behavior, Animal; Bicuculline; Drug Interactions; Electroencephalography; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Seizures

1985
Proceedings: Potentiation of picrotoxin-induced convulsions in mice by antidepressants. Specificity of the effect.
    British journal of pharmacology, 1974, Volume: 52, Issue:3

    Topics: Animals; Anticonvulsants; Antidepressive Agents; Central Nervous System Stimulants; Drug Synergism; Male; Mice; Mice, Inbred Strains; Picrotoxin; Seizures; Tranquilizing Agents

1974
The action of convulsants on neuronal and gross wave activity in the thalamus and in the cortex.
    Electroencephalography and clinical neurophysiology, 1963

    Topics: Animals; Cats; Cerebral Cortex; Injections, Intravenous; Neurons; Pentylenetetrazole; Picrotoxin; Seizures; Thalamus

1963
On the mechanisms of picrotoxin epileptic seizure (macro- and micro-electrode investigations).
    Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:4

    Topics: Action Potentials; Animals; Cats; Cerebral Cortex; Electroencephalography; Electrophysiology; Neurons; Picrotoxin; Seizures

1969
The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.
    Electroencephalography and clinical neurophysiology, 1970, Volume: 29, Issue:2

    Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrocardiography; Electroencephalography; Picrotoxin; Rabbits; Respiration; Seizures

1970
The developing animal as a model.
    Epilepsia, 1969, Volume: 10, Issue:2

    Topics: Age Factors; Animals; Barbiturates; Brain; Central Nervous System; Electric Stimulation; Electroshock; Fetus; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Reflex; Seizures; Spinal Cord; Strychnine; Synaptic Transmission; Time Factors

1969
Proceedings: Presynaptic inhibition and the depressant actions of GABA and glycine in the feline cuneate nucleus: changes related to electrographic seizure activity.
    The Journal of physiology, 1973, Volume: 234, Issue:2

    Topics: Alkaloids; Aminobutyrates; Animals; Cats; Dioxoles; Electroencephalography; Glycine; Injections, Intravenous; Iontophoresis; Isoquinolines; Medulla Oblongata; Neural Inhibition; Picrotoxin; Seizures; Sensory Receptor Cells; Strychnine; Synaptic Transmission

1973
Chemical studies in relation to convulsive conditions. Effect of Telodrin on the liberation and utilization of ammonia in rat brain.
    The Biochemical journal, 1964, Volume: 90, Issue:1

    Topics: Amino Acids; Ammonia; Animals; Benzofurans; Brain; Central Nervous System Stimulants; Chromatography, Paper; Electric Stimulation; Glutamates; Glutamine; Ketoglutaric Acids; Picrotoxin; Pyruvates; Rats; Seizures

1964
Pulmonary changes with convulsions induced by drugs and oxygen at high pressure.
    Journal of applied physiology, 1966, Volume: 21, Issue:3

    Topics: Amino Alcohols; Animals; Central Nervous System Stimulants; Chlorpromazine; Curare; Dibenzylchlorethamine; Hyperbaric Oxygenation; Lung; Oxygen; Pentobarbital; Pentylenetetrazole; Picrotoxin; Pulmonary Edema; Rats; Seizures; Sympatholytics

1966
Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.
    Epilepsia, 1969, Volume: 10, Issue:2

    Topics: Aluminum; Aminobutyrates; Animals; Bemegride; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Diphenhydramine; Electroencephalography; Ethers; Fluorine; Haplorhini; Hydroxides; Hydroxylamines; Isoflurophate; Pentylenetetrazole; Picrotoxin; Pyridoxine; Reserpine; Seizures; Semicarbazides; Strychnine

1969
Hydrazide-induced seizures and cerebral levels of gamma-aminobutyric acid: a re-evaluation.
    Journal of neurochemistry, 1970, Volume: 17, Issue:8

    Topics: Age Factors; Aminobutyrates; Animals; Animals, Newborn; Brain Chemistry; Central Nervous System Stimulants; Centrifugation; Chickens; Freeze Drying; Picrotoxin; Seizures; Semicarbazides; Strychnine; Thiosemicarbazones

1970
Effects of drugs acting alone and in combination on the motor activity of intact mice.
    British journal of pharmacology, 1970, Volume: 39, Issue:4

    Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central Nervous System Stimulants; Chlorpromazine; Diazepam; Diphenhydramine; Female; Glutamates; Hydroxybutyrates; Lactones; Meperidine; Meprobamate; Mice; Motor Activity; Nikethamide; Phenobarbital; Picrotoxin; Promethazine; Reflex; Scopolamine; Seizures; Strychnine; Tranquilizing Agents

1970
Effects of general stimulant drugs on the electrical responses of isolated slabs of cat's cerebral cortex.
    British journal of pharmacology, 1970, Volume: 39, Issue:4

    Topics: Action Potentials; Animals; Bemegride; Caffeine; Cats; Central Nervous System Stimulants; Cerebral Cortex; Female; Glutamates; In Vitro Techniques; Male; Nikethamide; Picrotoxin; Seizures; Stimulation, Chemical; Strychnine

1970
Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine.
    Chemical & pharmaceutical bulletin, 1971, Volume: 19, Issue:6

    Topics: Amides; Amino Acids; Animals; Bemegride; Brain; Brain Chemistry; Caffeine; Carbon Isotopes; Central Nervous System; Depression, Chemical; Glutamine; Hexobarbital; Liver; Male; Mice; Pentylenetetrazole; Picrotoxin; Piperidines; Seizures; Sleep; Strychnine

1971
Resistance to picrotoxin poisoning induced by catatoxic steroids.
    Agents and actions, 1970, Volume: 1, Issue:3

    Topics: Anabolic Agents; Androstanes; Animals; Cholesterol; Desoxycorticosterone; Ethylestrenol; Female; Fluorine; Ketosteroids; Oxandrolone; Picrotoxin; Poisoning; Prednisolone; Pregnanediones; Pregnanes; Progesterone; Rats; Seizures; Spironolactone; Steroids; Triamcinolone

1970
Convulsive activity in garter snakes.
    Behavioral biology, 1972, Volume: 7, Issue:2

    Topics: Animals; Behavior, Animal; Bemegride; Body Temperature; Brain; Central Nervous System; Central Nervous System Stimulants; Electroencephalography; Evoked Potentials; Pentylenetetrazole; Picrotoxin; Receptors, Adrenergic; Receptors, Cholinergic; Seizures; Snakes; Strychnine; Synapses

1972
Inhibition of post-decapitation convulsions by reserpine.
    Experientia, 1973, Volume: 29, Issue:7

    Topics: Animals; Cervical Vertebrae; Cordotomy; Male; Norepinephrine; Pentylenetetrazole; Picrotoxin; Rats; Reserpine; Seizures; Strychnine

1973
Changes in sensitivity to convulsion in mice with olfactory bulb ablation.
    Japanese journal of pharmacology, 1972, Volume: 22, Issue:4

    Topics: Animals; Cyclohexanes; Electroshock; Limbic System; Male; Mice; Olfactory Bulb; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine

1972
Some characteristics of cortical inhibition induced by local stimulation and by an acute seizure focus in the cat.
    British journal of pharmacology, 1972, Volume: 46, Issue:3

    Topics: Animals; Cats; Cerebral Cortex; Injections, Intravenous; Iontophoresis; Isoquinolines; Neural Inhibition; Neurons; Penicillin G; Picrotoxin; Seizures

1972
Effect of lithium on acute oxygen toxicity and associated changes in brain gamma-aminobutyric acid.
    Aerospace medicine, 1973, Volume: 44, Issue:4

    Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Hyperbaric Oxygenation; Lithium; Magnesium; Male; Manganese; Oxygen; Pentylenetetrazole; Picrotoxin; Pulmonary Edema; Rats; Seizures; Strychnine; Thiosemicarbazones; Zinc

1973
Glutamate and aspartate in cortical subarachnoid fluid in relation to convulsive activity.
    Brain research, 1973, May-17, Volume: 54

    Topics: Animals; Aspartic Acid; Azoles; Brain; Dogs; Glutamates; Methionine Sulfoximine; Picrotoxin; Seizures; Subarachnoid Space; Thiosemicarbazones

1973
Some studies on the convulsant action of folic acid.
    British journal of pharmacology, 1973, Volume: 48, Issue:2

    Topics: Alkaloids; Animals; Auditory Threshold; Cerebral Ventricles; Dioxoles; Electroshock; Folic Acid; Folic Acid Antagonists; Glutamates; Injections; Injections, Intravenous; Isoquinolines; Mice; Ouabain; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine

1973
Convulsions elicited by handling: a sensitive method of measuring CNS excitation in mice treated with reserpine or convulsant drugs.
    Psychopharmacologia, 1973, Aug-22, Volume: 32, Issue:1

    Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Ethanol; Humans; Male; Mice; Pentylenetetrazole; Picrotoxin; Reserpine; Seizures; Strychnine; Substance Withdrawal Syndrome; Time Factors

1973
Actions of GABA, picrotoxin and bicuculline on adrenal medulla.
    European journal of pharmacology, 1974, Volume: 27, Issue:1

    Topics: Acetylcholine; Adrenal Glands; Adrenal Medulla; Alkaloids; Aminobutyrates; Animals; Calcium; Catecholamines; Cattle; Dioxoles; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Isoquinolines; Picrotoxin; Potassium; Seizures; Strychnine

1974
Changes in local excitability produced by intrahippocampal injections of thiosemicarbazide and GABA.
    Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 170, Issue:1

    Topics: Aminobutyrates; Animals; Cats; Electroencephalography; Evoked Potentials; Hippocampus; Male; Picrotoxin; Seizures; Semicarbazides; Stereotaxic Techniques; Strychnine; Tubocurarine

1967
Effects of N, N' -diphenyldicarbamate-1,1-demethylol cyclopentane (Carmalon) on the spinal cord reflexes.
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:2

    Topics: Animals; Atropine; Barbiturates; Cyclopentanes; Depression, Chemical; Electric Stimulation; Male; Mephenesin; Mice; Pentylenetetrazole; Picrotoxin; Reflex; Seizures; Sleep; Spinal Cord; Strychnine

1968
The convulsive action of 2,5-dicarbethoxy 3,4-dihydroxythiophane (dicetol).
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:4

    Topics: Acetylcholine; Animals; Blood Pressure; Brain Chemistry; Cats; Depression, Chemical; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Mice; Muscles; Pentobarbital; Picrotoxin; Rabbits; Rats; Reserpine; Respiration; Seizures; Sleep; Thiophenes

1968
[Action of diazepam on the spinal cord reflex, with special reference to dorsal root reflex].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1969, Jul-20, Volume: 65, Issue:4

    Topics: Animals; Cats; Chlordiazepoxide; Denervation; Diazepam; Electric Stimulation; Evoked Potentials; Female; Injections, Intraperitoneal; Male; Mice; Picrotoxin; Reflex; Seizures; Solvents; Spinal Cord; Strychnine; Synapses; Time Factors

1969
Effects of various conditions on the movement of carbon atoms derived from glucose into and out of protein in rat brain.
    Canadian journal of biochemistry, 1970, Volume: 48, Issue:3

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Cerebral Cortex; Depression, Chemical; Glucose; Glutamates; Hypoxia; Injections, Intravenous; Insulin; Male; Metabolism; Nerve Tissue Proteins; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stimulation, Chemical; Time Factors

1970
Incorporation of carbon atoms from glucose into free amino acids in brain under normal and altered conditions.
    Canadian journal of biochemistry, 1970, Volume: 48, Issue:3

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Depression, Chemical; Glucose; Glutamates; Glutamine; Glycolates; Hypoxia; Injections, Intravenous; Lactates; Male; Metabolism; Methods; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stimulation, Chemical; Time Factors

1970
Protein-bound amide groups in brain.
    Canadian journal of biochemistry, 1970, Volume: 48, Issue:10

    Topics: Amides; Ammonia; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Cerebral Cortex; Glucose; Glutamates; Glutamine; Hydrochloric Acid; Nerve Tissue Proteins; Pentobarbital; Peptide Hydrolases; Picrotoxin; Protein Binding; Rats; Seizures; Streptomyces

1970
Effect of metal ions on oxygen toxicity.
    Aerospace medicine, 1970, Volume: 41, Issue:12

    Topics: Animals; Atmospheric Pressure; Cobalt; Hydroxylamines; Hyperbaric Oxygenation; Injections, Intraperitoneal; Ions; Lung; Male; Manganese; Metals; Methods; Oxygen; Pentylenetetrazole; Picrotoxin; Potassium; Pulmonary Edema; Rats; Seizures; Strychnine; Thiosemicarbazones; Zinc

1970
Concerning the depressant activity of analeptics (pentylenetetrazol, bemegride, nikethamide, picrotoxin).
    Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 188, Issue:2

    Topics: Anesthesia; Animals; Barbiturates; Bemegride; Depression, Chemical; Guinea Pigs; Nikethamide; Nitrous Oxide; Pentylenetetrazole; Picrotoxin; Rats; Seizures

1970
[Introduction of mass psychology in animals to pharmacology. 7. Mutural relation in convulsion of El-mice and drugs acting on the central nervous system].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1970, Volume: 66, Issue:6

    Topics: Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Hydantoins; Imidazoles; Mice; Phenobarbital; Picrotoxin; Psychology; Seizures

1970
The effect of intraperitoneal injections of hyperosmotic solutions on convulsions induced by drugs and hyperbaric oxygen.
    Canadian journal of physiology and pharmacology, 1968, Volume: 46, Issue:4

    Topics: Aminobutyrates; Animals; Brain Diseases; Dehydration; Glucose; Hyperbaric Oxygenation; Hypertonic Solutions; Injections, Intraperitoneal; Male; Osmolar Concentration; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Semicarbazides; Urea

1968
Convulsions and the gamma-aminobutyric acid content of rat brain.
    Canadian journal of physiology and pharmacology, 1968, Volume: 46, Issue:5

    Topics: Alanine; Aminobutyrates; Animals; Brain Chemistry; Hyperbaric Oxygenation; Osmolar Concentration; Oxygen; Picrotoxin; Rats; Seizures

1968
Further studies on chemically induced siezures and their antagonism by anticonvulsants during postnatal development in the mouse.
    Acta pharmacologica et toxicologica, 1968, Volume: 26, Issue:2

    Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Trimethadione

1968
Electrophysiological investigations on homopantothenic acid.
    The Journal of vitaminology, 1968, Dec-10, Volume: 14, Issue:4

    Topics: Animals; Brain; Cats; Cerebral Cortex; Electroencephalography; Electrophysiology; Male; Pantothenic Acid; Pentylenetetrazole; Picrotoxin; Rabbits; Seizures; Time Factors

1968
Macro- and micro-electrode investigations on the mechanisms of pycrotoxine epileptic seizure.
    Comptes rendus de l'Academie Bulgare des sciences : sciences mathematiques et naturelles, 1968, Volume: 21, Issue:9

    Topics: Animals; Cats; Electroencephalography; Picrotoxin; Seizures

1968
On the effect of cardiazol and picrotoxin on cats with crossed blood circulation.
    Comptes rendus de l'Academie Bulgare des sciences : sciences mathematiques et naturelles, 1968, Volume: 21, Issue:8

    Topics: Animals; Blood Transfusion; Cats; Electroencephalography; Pentylenetetrazole; Picrotoxin; Seizures

1968
Effect of picrotoxin and pyramidon in cats with strychnine cortical focus during crossed blood circulation.
    Comptes rendus de l'Academie Bulgare des sciences : sciences mathematiques et naturelles, 1968, Volume: 21, Issue:8

    Topics: Aminopyrine; Animals; Blood Transfusion; Cats; Electroencephalography; Picrotoxin; Seizures; Strychnine

1968
[On the inflence of fluid volume on the efficacy of bemegride, Pentetrazole and picrotoxin in phenobarbital poisoning].
    Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 174, Issue:2

    Topics: Animals; Bemegride; Mice; Pentylenetetrazole; Pharmaceutical Vehicles; Phenobarbital; Picrotoxin; Seizures; Sodium Chloride; Solutions; Suspensions

1968
Pharmacological significances of peptidase and proteinase in the brain. I. Enzymatic inactivation of bradykinin in rat brain.
    Biochemical pharmacology, 1969, Volume: 18, Issue:1

    Topics: Animals; Biological Assay; Bradykinin; Brain; Brain Stem; Carboxypeptidases; Cell Nucleus; Cerebellum; Cerebral Cortex; Depression, Chemical; Endopeptidases; Hydrogen-Ion Concentration; Male; Microsomes; Mitochondria; Muscle, Smooth; Nerve Tissue Proteins; Pentylenetetrazole; Peptide Hydrolases; Picrotoxin; Rats; Seizures; Stimulation, Chemical; Temperature

1969
Elevation of gamma-aminobutyric acid in brain with amino-oxyacetic acid and susceptibility to convulsive seizures in mice: a quantitative re-evaluation.
    Biochemical pharmacology, 1966, Volume: 15, Issue:3

    Topics: Acetates; Adenosine Triphosphate; Aminobutyrates; Animals; Brain; Carboxy-Lyases; Electroconvulsive Therapy; In Vitro Techniques; Mice; Nerve Endings; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine

1966