picrotoxin has been researched along with Seizures in 475 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 208 (43.79) | 18.7374 |
| 1990's | 112 (23.58) | 18.2507 |
| 2000's | 95 (20.00) | 29.6817 |
| 2010's | 45 (9.47) | 24.3611 |
| 2020's | 15 (3.16) | 2.80 |
| Authors | Studies |
|---|---|
| Fatima, A; Maqbool, S; Sadaf, R; Younus, I | 1 |
| Distler, U; Ihbe, N; Kürten, T; Mittmann, T; Sielaff, M; Tenzer, S; Ueberbach, T | 1 |
| Mishchenko, M; Shtrygol, D; Shtrygol, S; Tsyvunin, V | 1 |
| Adeyemi, OO; Afolayan, O; Ajayi, AM; Ben-Azu, B; Ishola, IO; James, AB; Nwose, E; Olubodun-Obadun, TG; Umukoro, S | 1 |
| Georgiyants, V; Kayal, WE; Mishchenko, M; Severina, H; Shtrygol, D; Shtrygol, S; Zalevskyi, S | 1 |
| Adassi, MB; Foutsop, AF; Kom, TD; Ngo Bum, E; Ngoupaye, GT; Yassi, FB | 1 |
| Bao, X; Cai, J; Han, QT; Li, F; Qu, J; Shi, Q; Wang, XL; Yang, WQ; Yu, SS; Zang, C; Zhang, CJ; Zhang, D; Zhou, L | 1 |
| Deyama, S; Ito, S; Izumi, S; Kaneda, K; Niitani, K; Nishitani, N; Wada, S | 1 |
| Bandara, SB; Carty, DR; Harvey, DJ; Lein, PJ; Pressly, B; Singh, V; Vasylieva, N; Wulff, H | 1 |
| Adeyeba, OA; Awosan, OB; Ayankunle, AA; Kolawole, OT; Onaolapo, OJ; Wakeel, OK | 1 |
| Ahamad, T; Dhawale, K; Gawande, MB; Ghorai, SK; Nilkanth, PR; Sathiyanarayanan, A; Shelke, SN | 1 |
| Chen, HY; Chen, YC; Huang, LC; Yu, JH | 1 |
| Carmona-Aparicio, L; González-Trujano, ME; Martínez-Vargas, D; Santos-Valencia, F; Urbina-Trejo, E; Villasana-Salazar, B | 1 |
| Garcia, V; Voss, LJ | 1 |
| Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD | 1 |
| Barker, S; Costa, ACS; Faber, J; Pinheiro, DJLL; Scorza, CA; Scott-McKean, JJ; Stasko, MR; Victorino, DB | 1 |
| Carandini, M; Kullmann, DM; Rossi, LF; Wykes, RC | 1 |
| He, Z; Li, D; Li, P; Li, Y; Liang, L; Luo, X; Ma, J; Qin, L; Sun, Y; Zhou, X | 1 |
| da Rosa, MS; Gonçalves, D; Leipnitz, G; Luft, JG; Morás, AM; Moura, DJ; Pereira, P; Pflüger, PF; Regner, GG; Steffens, L | 1 |
| Distler, MG; Escayg, A; Gorfinkle, N; Palmer, AA; Papale, LA; Termini, J; Winawer, MR; Wuenschell, GE | 1 |
| Imoto, K; Ishihara, H; Kaneko, K; Kase, D; Nairn, AC; Obata, K; Yamagata, Y | 1 |
| Dhir, A; Rogawski, MA; Zolkowska, D | 1 |
| Aguiar, CC; Almeida, AB; Araújo, PV; Chaves, EM; de Barros Viana, GS; do Vale, OC; Leal, LK; Macêdo, DS; Vasconcelos, GS; Vasconcelos, SM | 1 |
| Aykan, DA; Erkoseoglu, I; Kadioglu, M; Kalyoncu, NI; Kesim, M; Yaris, E; Yulug, E | 1 |
| Ahangar, N; Ebrahimzadeh, MA; Nabavi, SF; Nabavi, SM | 1 |
| Bennett, CF; Chen, G; Cirrito, JR; DeVos, SL; Goncharoff, DK; Holtzman, DM; Kebodeaux, CS; Maloney, SE; Miller, TM; Rigo, F; Schuler, DR; Stewart, FR; Wozniak, DF; Yamada, K | 1 |
| Chow, E; Gane, J; Jeffrey, M; Lang, M; Wu, C; Zhang, L | 1 |
| Alhumayyd, MS; Bukhari, IA; Gilani, AH; Mahesar, AL; Pivac, N | 1 |
| Abdel Razzak, RL; Alzoubi, KH; Hasan, ZA | 1 |
| Ananthalakshmi, KV; Edafiogho, IO; Kombian, SB; Phillips, OA; Qaddoumi, MG | 1 |
| Chang, CF; Chen, CS; Chuang, TH; Mukkanti, K; Pusuluri, S; Sorra, K; Wu, CR | 1 |
| Abramov, DA; Kapitsa, IG; Kaplun, AP; Prokhorov, DI; Sariev, AK; Seifulla, RD; Shiriaeva, MV; Voronina, TA; Zhuravko, AS | 1 |
| Al-Obaid, AM; Al-Salem, HS; El-Messery, SM; El-Subbagh, HI; El-Taher, KE; Hegazy, GH | 1 |
| Cao, L; Di, ZL; Jiang, Y; Lei, H; Tian, Y; Zhang, GJ | 1 |
| Avoli, M; Benini, R; D'Antuono, M; de Guzman, P; Köhling, R | 1 |
| Pillai, KK; Vohora, D | 1 |
| Deepakumari, HN; Jayanna, BK; Prashanth, MK; Revanasiddappa, HD; Veeresh, B | 1 |
| Albert, GW; Howard, MA; Schnizler, MK; Severson, MA; Welsh, MJ; Wemmie, JA; Ziemann, AE | 1 |
| Ren, L; Tsang, SY; Wang, F; Xu, Z; Xue, H | 1 |
| BALLIN, HM; GELLHORN, E | 1 |
| Jain, R; Kaur, N; Krishnamoorthy, S; Meena, CL; Monga, V; Pawar, C; Rajput, SK; Sharma, SS | 1 |
| Furutani, S; Itoh, A; Nakajima, H; Oshiro, H; Sugimoto, Y; Sun, S; Tanahashi, T; Yamada, J | 1 |
| Barth, AL; Benedetti, BL; Sheehan, JJ | 1 |
| Ares-Pena, FJ; Bregains, J; Cadarso-Suárez, C; Jorge-Barreiro, FJ; López-Martín, E; Relova-Quinteiro, JL | 1 |
| Amabeoku, G | 1 |
| Shalini, M; Sriram, D; Stables, JP; Yogeeswari, P | 1 |
| Gholamreza, S; Golnaz, E; Mohammad, H; Reza, HM | 1 |
| Héja, L; Kardos, J; Lasztóczi, B; Nyitrai, G | 1 |
| Avoli, M; Biagini, G; D'Antuono, M; Gotman, J; Köhling, R; Ricalzone, S | 1 |
| Behravan, E; Dadollahi, Z; Etemad, L; Heidari, MR; Mehrabani, M; Mehrabi, H; Pourzadeh-Hosseini, M | 1 |
| Ingole, S; Jain, G; Jain, R; Kaur, N; Meena, CL; Monga, V; Rajput, SK; Sharma, SS; Singh, JN | 1 |
| Arora, SK; Chakrabarti, A; Hota, D; Khanduja, KL; Prakash, A; Singh, S | 1 |
| Araki, H; Kawasaki, H; Ochi, R; Suemaru, K | 1 |
| Aladeokin, AC; Umukoro, S | 1 |
| Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M | 1 |
| Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G | 1 |
| Adeyemi, OO; Aigbe, FR; Akindele, AJ; Fagbo, FI; Yemitan, OK | 1 |
| Cachat, J; Chang, K; Dileo, J; Frank, K; Gaikwad, S; Gilder, T; Grossman, L; Kalueff, AV; Stewart, A; Suciu, C; Utterback, E; Wong, K; Wu, N | 1 |
| El Idrissi, A; L'Amoreaux, WJ; Marsillo, A | 1 |
| Jacobson, G; Melin, S; Sleigh, JW; Voss, LJ | 1 |
| de Freitas, RM; Feng, D; Silva, Fde O; Silva, MG | 1 |
| Abbasifard, M; Azimzadeh, BS; Behravan, E; Etemad, L; Heidari, M; Heidari, MR; Moshiri, M | 1 |
| Alvarez-Figueiras, M; Ares-Pena, FJ; Cadarso-Suárez, C; Carballo-Quintás, M; López-Martín, E; Martínez-Silva, I | 1 |
| Desaer, C; Ramakrishnan, L | 1 |
| Bayliss, DA; Chen, X; Du, G; Kapur, J; Shu, S; Todorovic, MS | 1 |
| Kokaia, M | 1 |
| Adio, O; Fageyinbo, S; Sowemimo, AA | 1 |
| Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R | 1 |
| Cen, D; He, Z; Li, D; Li, P; Liang, L; Luo, X; Meng, Z | 1 |
| Cho, S; Han, D; Jeon, YJ; Jin, YH; Jo, J; Kim, SB; Lee, SH; Shimizu, M; Yang, H; Yong, H; Yoon, M | 1 |
| Banks, CN; Bruun, DA; Dhir, A; Hammock, BD; Inceoglu, B; Lein, PJ; McCoy, MR; Rogawski, MA; Sanborn, JR; Zolkowska, D | 1 |
| Aslan, M; Deliorman Orhan, D; Orhan, IE; Orhan, N; Süküroğlu, M | 1 |
| Baines, RA; Günay, C; Lin, WH; Marley, R; Prinz, AA | 1 |
| Kamal, SM | 1 |
| Abbas, SY; Abd-Alrahman, SN; Ahmed, GF; Ammar, RM; Ammar, YA; Farag, AA | 1 |
| Du, XM; Guo, YT; Shoyama, Y; Sun, NY; Takizawa, N | 1 |
| Paul, V; Subramanian, EH | 1 |
| Bernardi, MM; Spinosa, Hde S; Stilck, SR | 1 |
| Bough, KJ; Eagles, DA; Gudi, K; Han, FT; Rathod, AH | 1 |
| Pericić, D; Svob, D | 1 |
| Chaichantipyuth, C; Matsumoto, K; Murakami, Y; Sukma, M; Tohda, M; Watanabe, H | 1 |
| Kalyoncu, NI; Tan, M; Tan, U | 1 |
| Paul, V | 1 |
| Chan, MN; Huen, MS; Leung, JW; Lui, WS; Ng, W; Wong, JT; Xue, H | 1 |
| Jayakumar, R; Rajasekaran, K; Venkatachalam, K | 1 |
| Ekambaram, P; Paul, V; Reddy, L | 2 |
| Matsumoto, K; Murakami, Y; Nomura, H; Takahata, H; Taki, K; Watanabe, H | 1 |
| Carvalho, JC; Carvalho, JE; Perazzo, FF; Rehder, VL | 1 |
| MEIDINGER, F | 1 |
| BURT, GS | 1 |
| HAHN, F; OBERDORF, A | 1 |
| GRUNDY, HF | 1 |
| CARTER, SH; ROA, PD; STONE, WE; TEWS, JK | 1 |
| VARDAPETIAN, GA | 1 |
| SIGG, EB; WARNER, CL; YEN, HC | 1 |
| CHUBB, FL; HAJDU, A; KOMLOSSY, J; LEE, CF; MCCOLL, JD | 1 |
| BASIL, B; BLAIR, AM; HOLMES, SW | 1 |
| FISCHER, R; LISS, L; SOLZE, DA | 1 |
| GHOSH, JJ; SIKDAR, K | 1 |
| SYTINSKY, IA; THINH, NT | 1 |
| MAGISTRETTI, MJ; SETNIKAR, I | 1 |
| AKINTONWA, DA; HATHWAY, DE; MALLINSON, A | 1 |
| RAMWELL, PW; SHAW, JE | 1 |
| Fei, J; Guo, LH; Ma, YH; Mei, ZT; Zhao, WJ | 1 |
| Boehrer, A; Nehlig, A; Vergnes, M | 1 |
| Ekambaram, P; Vanaja, P | 1 |
| Ha, JH; Koo, BS; Lee, DU; Lee, SI | 1 |
| Reddy, DS | 1 |
| Ekambaram, P; Paul, V | 2 |
| Hu, B; Karnup, S; Stelzer, A; Zhou, L | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Szyndler, J; Taracha, E; Turzyńska, D; Walkowiak, J; Wisłowska, A; Zienowicz, M | 1 |
| Arkhipov, VI; Kulagina, TP; Shevchenko, NA | 1 |
| Flerov, MA; Gerasimova, IA; Tolstukhina, TI | 1 |
| Lazić, J; Pericić, D; Svob Strac, D | 1 |
| da Costa, F; de Oliveira, DL; Perry, ML; Scheibel, F; Schweigert, ID; Souza, DO; Wofchuk, ST | 1 |
| Godlevskii, LS; Kobolev, EV | 1 |
| Sierra-Marcuño, G; Sierra-Paredes, G; Vázquez-López, A | 1 |
| Hitti, FL; Kim, U; Lee, KH; Leiter, JC; Roberts, DW; Shalinsky, MH | 1 |
| Benedito, MA; Contó, MB; de Carvalho, JG | 1 |
| Jazvinsćak Jembrek, M; Lazić, J; Pericić, D; Svob Strac, D | 1 |
| Acharya, MM; Katyare, SS | 1 |
| Ojewole, JA | 3 |
| Ares-Pena, FJ; Gallego-Gómez, R; Jorge-Barreiro, FJ; López-Martín, E; Peleteiro-Fernández, M; Relova-Quinteiro, JL | 1 |
| Hasan, Z; Otoom, S | 1 |
| Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K | 1 |
| Dhir, A; Kulkarni, SK; Naidu, PS | 1 |
| Araújo, DA; Cruz, JS; de Almeida, RN; de Sousa, DP; Gonçalves, JC; Quintans-Júnior, L | 1 |
| Núñez-Rodriguez, A; Oreiro-García, T; Sierra-Marcuño, G; Sierra-Paredes, G; Vázquez-López, A | 2 |
| Pericić, D; Strac, DS; Vlainić, J | 2 |
| Chen, Y; Hou, L; Li, K; Wang, J | 1 |
| Amabeoku, GJ; Ojewole, JA | 1 |
| Chang, SM; Ha, JH; Lee, JT; Lee, MG | 1 |
| Avallone, R; Baraldi, M; Brusiani, F; Losi, G; Puia, G; Rivasi, M; Zanoli, P; Zavatti, M | 1 |
| Chouinard, SW; Littleton, JT; Saraswati, S; Stilwell, GE | 1 |
| Gütschow, M; Kubacka, M; Librowski, T; Meusel, M; Müller, CE; Scolari, S | 1 |
| Amabeoku, GJ; Green, I; Kabatende, J | 1 |
| Kubová, H; Mares, P; Tchekalarova, J | 1 |
| Hyrc, K; Perry, G; Rothman, SM; Schmidt, BF; Yang, XF | 1 |
| Akula, KK; Dhir, A; Kulkarni, SK | 1 |
| Alves, PB; Antoniolli, AR; Blank, AF; Bonjardim, LR; Leite, BS; Lessa, NM; Quintans-Júnior, LJ; Santos, MR; Souza, TT | 1 |
| Mustafa, AA; Salih, MA | 1 |
| Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I | 1 |
| Gillardin, JM; Heulard, I; Verleye, M | 1 |
| Choi, SY; Choi, UK; Kang, JH; Kang, TC; Kim, DW; Kim, HT; Kim, JE; Kwak, SE; Kwon, OS; Lee, SJ | 1 |
| Saito, S; Tokunaga, Y | 1 |
| DeFeudis, FV; Elliott, KA | 2 |
| Kelkar, MR; Sethy, VH; Sheth, UK | 1 |
| Kádár, T; Penke, B; Pesti, A; Telegdy, G | 1 |
| File, SE | 3 |
| Calder, LD; Karler, R; Sangdee, P; Turkanis, SA | 1 |
| Calder, LD; Karler, R; Turkanis, SA | 1 |
| Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH | 1 |
| Brahmapurikar, MT; Mateenuddin, M; Sadre, NL | 1 |
| Leeb-Lundberg, F; Napias, C; Olsen, RW | 1 |
| Flicker, C; Geyer, MA | 1 |
| Hara, S; Kitagawa, H; Satoh, T | 1 |
| Alpert, M; Triner, L; Verosky, M; Vulliemoz, Y | 1 |
| Georgiev, VP; Lambadjieva, ND | 1 |
| Olsen, RW | 1 |
| Corda, MG; Costa, E; Guidotti, A | 1 |
| Batts, CC; Cowen, PJ; Grahame-Smith, DG; Green, AR; Nutt, DJ | 1 |
| Hablitz, JJ; Johnston, D; Lebeda, FJ | 1 |
| Engel, J; Liljequist, S | 1 |
| Gomes, C; Leite, JR; Pagliusi, SR; Trolin, G | 1 |
| Kádár, T; Penke, B; Pesti, A; Telegdy, G; Tóth, G; Zarándi, M | 1 |
| Ashton, D | 1 |
| Jensen, LH; Petersen, EN | 1 |
| File, SE; Green, AR; Nutt, DJ; Vincent, ND | 1 |
| Manev, H; Pericić, D | 3 |
| Jog, MV; Kulkarni, SK | 1 |
| Mauss, EA; Wallenstein, MC | 1 |
| Fujii, T; Ikeda, H; Nonaka, C | 1 |
| Andreas, K; Dienel, A; Schmidt, J | 1 |
| Ciesielski, L; Mandel, P; Simler, S | 1 |
| Kovács, GL; Szabó, G; Telegdy, G | 2 |
| Crider, AM; Hinko, CN; Seibert, K | 1 |
| Collins, RC; Lothman, EW; Tearse, RG | 1 |
| Foote, F; Gale, K | 1 |
| Barbadoro, E; Graziani, G; Testa, R; Tirone, F | 1 |
| File, SE; Simmonds, MA | 1 |
| Hablitz, JJ | 1 |
| Kofman, O; Mintz, M; Myslobodsky, M | 1 |
| Ciesielski, L; Klein, M; Mandel, P; Simler, S | 1 |
| Kalichman, MW | 1 |
| Betin, C; Blavet, N; Clostre, F; DeFeudis, FV | 1 |
| Collins, RC | 1 |
| Menon, MK; Vivonia, CA | 1 |
| Di Chiara, G; Imperato, A | 1 |
| Kofman, O; Mintz, M; Myslobodsky, MS | 1 |
| Pericić, D | 1 |
| Burnham, WM; Kalichman, MW; Livingston, KE | 1 |
| Myslobodsky, MS; Valenstein, ES | 1 |
| Barker, JL; MacDonald, JF | 1 |
| Javid, MJ; Stone, WE | 1 |
| Burnham, WM; Kalichman, MW | 1 |
| Bourn, WM; Reigel, CE | 1 |
| Hiscock, JJ; Mackenzie, L; Medvedev, A; Willoughby, JO | 2 |
| Brusentsov, AI; Godlevskiĭ, LS; Mikhaleva, II; Prudchenko, IA; Shandra, AA; Vast'ianov, RS; Zaporozhan, VN | 1 |
| Abu-Laban, A; Hasan, Z; Khatib, S | 1 |
| Brightman, T; Flynn, EJ; McArdle, JJ; Ortiz-Jimenez, E; Wu, WH; Ye, JH | 1 |
| Godlevsky, LS; Mazarati, AM; Mikhaleva, II; Shandra, AA; Vastyanov, RS | 1 |
| Dunham, L; Guillet, R | 1 |
| Ali, BH; Banna, NR; Bashir, AK; Tanira, MO | 1 |
| Imaizumi, M; Machida, H; Miyazaki, S | 1 |
| Sainsbury, RS; Teskey, GC; Trepel, C; Valentine, PA | 1 |
| Obara, N | 1 |
| Basile, AS; Drugan, RC; Ferland, RJ; Ha, JH | 1 |
| Chirkov, YP; Godlevsky, LS; Mazarati, AM; Panenko, AV; Shandra, AA; Tkachenko, IV | 1 |
| Bolster, B; Dakshinamurti, K; Sharma, SK | 1 |
| Adachi, I; Eigyo, M; Inoue, Y; Ishibashi, C; Koyabu, K; Matsushita, A; Murata, S; Sakaguchi, I; Shiomi, T; Ueda, M | 1 |
| Freeman, P; Meade, HM; Seeley, NA; Sturman, G | 1 |
| Cao, B; Hong, GX | 1 |
| Askanazi, J; Manner, T; Petersen, AJ; Skeie, B; Steen, PA | 1 |
| Getova, DP; Maslarova, JE; Nikolov, RK; Semkova, IS | 1 |
| Kazi, M; Paul, V | 1 |
| Hirayama, K; Matsuura, S; Murata, R | 1 |
| Kenigs, V; Nores, WL; Olson, GA; Olson, RD; Thomas, J | 1 |
| Amabeoku, GJ; Chikuni, O | 1 |
| Balasubramaniam, E; Kazi, M; Paul, V; Sheela, S | 1 |
| Nores, WL; Pariser, R; Thomas, J | 1 |
| Borowski, TB; Kirkby, RD; Kokkinidis, L | 1 |
| al-Hader, AF; Hasan, MM; Hasan, ZA; Takrouri, MS | 1 |
| Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J | 1 |
| Bernardi, MM; Gorniak, SL; Massoco, CO; Silva, MR; Spinosa, MS | 1 |
| Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS | 1 |
| Obrenovitch, TP; Urenjak, J; Zilkha, E | 1 |
| Hiscock, JJ; Mackenzie, L; Willoughby, JO | 3 |
| Carroll, DM; Grossman, AB; Kirkby, RD; Subramaniam, S | 1 |
| Chiu, TH; Rosenberg, HC; Zhao, TJ | 1 |
| Endo, T; Hara, S; Iwata, N; Kano, S; Kuriiwa, F; Mukai, T | 1 |
| Bujas, M; Manev, H; Pericić, D | 1 |
| Feigenbaum, JJ; Howard, SG | 1 |
| Sierra-Marcuño, G; Sierra-Paredes, G | 1 |
| Montagne-Clavel, J; Oliveras, JL | 1 |
| Miyakawa, T; Niki, H; Tateishi, K; Yagi, T | 1 |
| Boivin, E; Catérini, R; Clarençon, D; Ellis, P; Fatôme, M; Gourmelon, P; Hille, B; Kerckhoeve, A; Renaudin, M | 1 |
| Cannizzaro, C; Cannizzaro, E; Gagliano, M; Mangiapane, N | 1 |
| Cross, AJ; Green, AR; Misra, A; Murray, TK; Snape, MF | 1 |
| Arkhipov, VI; Shilakina, TG | 1 |
| Golovko, AI; Kliuntina, TV; Kurganova, TA; Sofronov, GA | 1 |
| Chang, CC; Chiou, LC; Ling, JY | 1 |
| Badran, S; Olpe, HR; Schmutz, M | 1 |
| Mimaki, Y; Sashida, Y; Toshimizu, N; Yamada, K | 1 |
| Bonsignori, A; Colombo, M; Dostert, P; Fariello, RG; Heidempergher, F; McArthur, RA; Pevarello, P; Pinciroli, V; Post, C; Salvati, P; Varasi, M | 1 |
| Alexander, CB; Ellmore, TM; Kirkby, RD; Kokate, TG | 1 |
| Aguilar-Veiga, E; Galán-Valiente, J; Mendez-Alvarez, E; Sierra-Marcuño, G; Sierra-Paredes, G; Soto-Otero, R; Vazquez-Illanes, MD | 1 |
| Golovko, AI; Ivanov, MB; Shilov, VV; Sofronov, GA; Sviderskiĭ, OA | 1 |
| Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML | 1 |
| Amabeoku, GJ | 1 |
| Mackenzie, L; Willoughby, JO | 1 |
| Cornes, JM; Sierra-Marcuño, G; Sierra-Paredes, G | 1 |
| Jayakumar, AR; Jayakumar, R; Paul, V; Puviarasan, K; Sujatha, R | 1 |
| Kim, DC; Todd, MM | 1 |
| Boehrer, A; Marescaux, C; Reibel, S; Simler, S; Vergnes, M | 1 |
| Bijak, M; Chojnacka-Wójcik, E; Czuczwar, SJ; Kroczka, B; Kłodzińska, A; Pilc, A; Swiader, M | 1 |
| Chae, WG; Choi, H; Choi, J; Jahng, Y; Je, SM; Kim, EK; Kim, TH; Kim, YC; Lee, ES; Park, M; Zhao, LX | 1 |
| Jayakumar, AR; Paul, V | 1 |
| da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP | 1 |
| Aguilar-Veiga, E; Galán-Valiente, J; Sierra-Marcuño, G; Sierra-Paredes, G; Vazquez-Illanes, MD | 1 |
| Atapour, N; Kalantaripour, TP; Niazi, M; Nourpanah, M | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Senra-Vidal, A; Sierra-Marcuño, G; Sierra-Paredes, G | 1 |
| Jazvinscak, M; Mirkovic, K; Pericic, D; Svob, D | 2 |
| Yakimovskii, A | 1 |
| Arkhipov, VI; Kolomiitseva, IK; Kulagina, TP | 1 |
| Paul, V; Rajasekaran, K; Reddy, PL | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Jayakumar, AR; Vanaja, P | 1 |
| Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K | 1 |
| Jazvinsćak Jembrek, M; Mirković Kos, K; Pericić, D; Svob, D | 1 |
| Arkhipov, V | 1 |
| Hiscock, JJ; Mackenzie, L; Medvedev, A; Pope, KJ; Willoughby, JO | 1 |
| Amabeoku, GJ; Bienvenu, E; Eagles, PK; Scott, G; Springfield, EP | 1 |
| Chopde, CT; Kasture, SB; Kasture, VS | 1 |
| Bidziński, A; Członkowska, AI; Kostowski, W; Krzaścik, P; Maciejak, P; Plaznik, A; Szyndler, J; Walkowiak, J | 1 |
| Stach, R | 1 |
| Chimote, KV; Moghe, PJ | 1 |
| Bures, J; Islam, S | 1 |
| Lothman, EW; Somjen, GG | 1 |
| Bures, J; Ueda, M | 1 |
| Georgiev, VP; Petkova, BP | 2 |
| McQueen, JK; Woodbury, DM | 1 |
| Costa, E; Guidotti, A; Mao, CC; Suria, A | 1 |
| Georgiev, VP; Petkova-Radkova, BP | 2 |
| Matthews, WD; McCafferty, GP | 1 |
| Stone, WE | 1 |
| Rose, D | 1 |
| Ciesielski, L; Kempf, E; Mack, G; Maitre, M; Mandel, P; Simler, S | 1 |
| Killam, KF; Rosenkranz, RP | 1 |
| Fukumori, R; Kitagawa, H; Minegishi, A; Nakagawa, I; Satoh, T; Yanaura, S | 1 |
| Mansour, R; Myslobodsky, MS | 1 |
| György, L | 1 |
| Anhut, H; Hertting, G; Steinhauer, HB | 1 |
| Simon, P; Soubrie, P | 1 |
| Bigler, ED | 1 |
| Gartside, IB; Hayes, AG; Straughan, DW | 1 |
| Georgiev, V | 1 |
| Frey, HH; Löscher, W | 1 |
| Breuker, EL; Dennis, BJ; Duong, T; Kerr, DI; Prager, RH; Ward, AD | 1 |
| Bures, J; Jonescu, E; Welzl, H | 1 |
| Kim, HJ; Routtenberg, A | 1 |
| Cowen, JS; Maxson, SC | 1 |
| Mulas, A; Pedata, F; Pepeu, G; Pepeu, IM | 1 |
| Georgiev, V; Markovska, V | 1 |
| Georgiev, VP; Markovska, VL | 1 |
| Conforti, N; Harel, D; Lavy, S; Raday, N | 1 |
| Borzek, G; Bures, J; von Schwarzenfeld, I | 1 |
| Meldrum, BS; Stephenson, JD | 1 |
| Marsden, CD; Meldrum, B; Pycock, C; Tarsy, D | 1 |
| Peesker, SJ; Wood, JD | 1 |
| Barbeau, A; Davidson, DL | 1 |
| Serratosa, J; Trullas, R; Tusell, JM; Vendrell, M | 1 |
| Bohuslav, T; Kubová, M; Mares, P | 1 |
| Golovko, AI; Sofronov, GA | 1 |
| Askanazi, J; Jellum, E; Manner, T; Petersen, AJ; Skeie, B; Steen, PA | 1 |
| Godlevskiĭ, LS; Oleĭnik, AA; Shandra, AA; Vikhrestiuk, SL | 1 |
| Mazarati, AM; Telegdy, G | 1 |
| Mizuki, Y; Sekimoto, M; Ushijima, I; Yamada, M | 1 |
| Godlevskiĭ, LS; Mazarati, AM; Shandra, AA; Vast'ianov, RS | 1 |
| Habibuddin, M; Pal, M; Pal, SP | 1 |
| Harro, J; Lang, A; Soosaar, A; Vasar, E | 1 |
| Bertolini, A; Marrama, D; Sandrini, M; Vergoni, AV | 1 |
| Aley, KO; Kulkarni, SK | 1 |
| Bitran, D; Kellogg, CK; Primus, RJ | 1 |
| Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Mazarati, AM; Nguyen, TT; Shandra, AA | 1 |
| Bierkamper, GG; Smith, KA | 1 |
| Lothman, EW; Stringer, JL | 1 |
| Drummer, HL; Woolley, DE | 1 |
| Dai, KS; Drummer, HL; Hasan, ZA; Woolley, DE | 1 |
| Liljequist, S | 1 |
| Bandyopadhyay, AA; Godlevsky, LS; Lobenko, AA; Mazarati, AM; Shandra, AA | 1 |
| Dreier, JP; Heinemann, U | 1 |
| Lok, SY; Meldrum, BS; Millan, MH; Obrenovitch, TP; Sarna, GS; Symon, L | 1 |
| Araki, H; Sano, M; Shimada, C; Tanaka, S | 1 |
| Carboni, G; Corda, MG; Frau, V; Giorgi, O; Lecca, D; Orlandi, M | 1 |
| Faktorová, M; Kubová, H; Mares, P | 1 |
| Rizzi, M; Samanin, R; Serafini, R; Stasi, MA; Vezzani, A; Viganò, G | 1 |
| Canney, DJ; Covey, DF; Ferrendelli, JA; Holland, KD; Levine, JA; McKeon, AC | 1 |
| McLean, JH; Thomas, J | 1 |
| Helton, DR; Williams, PD | 1 |
| Batatinha, MJ; Bernardi, MM; De Souza-Spinosa, H; Giorgi, R | 1 |
| Dai, KS; Woolley, DE | 1 |
| Burke, K; Chandler, CJ; Starr, BS; Starr, MS | 1 |
| Alkana, RL; Finn, DA; Jones, BL; Kobayashi, LS; Syapin, PJ | 1 |
| Becker, A; Grecksch, G; Matthies, H | 1 |
| Mares, P; Rokyta, R; Velísek, L; Velísková, J | 1 |
| Depaulis, A; Kempf, E; Liu, Z; Marescaux, C; Vergnes, M | 1 |
| De Barry, J; Mathis, C; Ungerer, A | 1 |
| Kádár, T; Schally, AV; Telegdy, G | 1 |
| Jones, RS; Lambert, JD | 1 |
| Mehta, AK; Ticku, MK | 3 |
| Dragunow, M | 1 |
| Campbell, JA; Greenwood, TD; Rathman, TL; Sleevi, MC; Wolfe, JF | 1 |
| Thomas, J | 2 |
| Depaulis, A; Liu, Z; Marescaux, C; Vergnes, M | 1 |
| Kaneto, H; Miwa, T; Nakamura, J; Sasaki, H; Shibasaki, J | 1 |
| Depaulis, A; Liu, Z; Marescaux, C; Micheletti, G; Vergnes, M; Warter, JM | 1 |
| Kulkarni, SK; Mehta, AK; Ticku, MK | 1 |
| Fishman, BE; Gianutsos, G | 3 |
| Dudek, BC; Kim, D; Phillips, TJ | 1 |
| Mizukawa, K; Otsuka, N; Watanabe, H | 1 |
| Ho, IK; Ito, Y; Lim, DK; Nabeshima, T | 1 |
| Paul, SM; Schwartz, RD; Seale, TW; Skolnick, P | 1 |
| Kulkarni, SK; Ticku, MK | 2 |
| Curran, T; Hempstead, J; Macgregor-Leon, PF; Mitchelmore, C; Morgan, JI; Sonnenberg, JL | 1 |
| Pierson, MG; Smith, KL; Swann, JW | 1 |
| Abdul-Ghani, AS; el-Lati, S; Ghneim, H; Saca'an, A | 1 |
| Korotzer, A; Pfaff, DW; Schwartz-Giblin, S | 1 |
| Bhadra, S; Idemudia, SO; Lal, H | 1 |
| Georgieva, J | 1 |
| Palermo-Neto, J; Sandoval, MR | 1 |
| Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Makul'kin, RF; Mazarati, AM; Shandra, AA | 1 |
| Ticku, MK | 1 |
| Gale, RG; Little, HJ; Nutt, DJ; Standing, BL; Taylor, SC | 1 |
| Ben-Shachar, D; Laufer, D; Livne, E; Silbermann, M | 1 |
| Goldberg, O; Teichberg, VI | 1 |
| Frenk, H; Liban, A; Teichberg, VI; Urca, G | 1 |
| Kent, AP; Webster, RA | 1 |
| Anderson, MC; Chung, EY; Van Woert, MH | 1 |
| Hutchison, AJ; Lehmann, J; McPherson, SE; Mondadori, C; Murphy, DE; Schmutz, M; Sinton, CM; Steel, DJ; Tsai, C; Williams, M | 1 |
| Hara, T; Kawazawa, S; Mizuki, Y; Ushijima, I; Yamada, M | 1 |
| Rastogi, SK; Ticku, MK | 1 |
| Beitz, AJ; Larson, AA | 1 |
| Bourn, WM; Garrett, RL | 1 |
| Maĭmets, MO; Nurk, AM; Riago, LK; Soosaar, AKh; Vasar, EE | 1 |
| Dewhurst, DG | 1 |
| Little, HJ; Nutt, DJ; Taylor, SC | 1 |
| Croucher, M; Gueremy, C; Le Fur, G; Legrand, JJ; Mazadier, M; Meldrum, B; Mizoule, J; Ollat, C; Uzan, A | 1 |
| Anić-Stojiljković, S; Manev, H; Pericić, D | 1 |
| Centra, M; Keeting, PE; Lysz, TW; Markey, K | 1 |
| Laporte, AM; Soubrié, P; Thiébot, MH | 1 |
| Brioni, JD; McGaugh, JL | 1 |
| Kantarev, N; Parisheva, Z; Toreva, D | 1 |
| Bayardo, F; Buzsáki, G; Gage, FH; Ponomareff, G; Shaw, T | 1 |
| Crabbe, JC; Feller, DJ; Harris, RA | 1 |
| Lister, RG; Nutt, DJ | 1 |
| Bernasconi, R; Christen, P; Hafner, T; Klein, M; Martin, P; Portet, C; Schmutz, M | 1 |
| Georgiev, V; Getova, D | 1 |
| Burdette, LJ; Dyer, RS | 1 |
| Evans, D; Smith, JC | 1 |
| Cain, DP | 1 |
| Durand, D | 1 |
| Piredda, SG; Swinyard, EA; Woodhead, JH | 1 |
| Geber, J; Manev, H; Pericić, D | 1 |
| Calderazzo-Filho, LS; Cavalheiro, EA; Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, WA | 1 |
| Davis, JM; Himwich, WA | 1 |
| Cowan, A; Harry, EJ | 1 |
| Bravo, MC; Negishi, K; Verzeano, M | 1 |
| Atsev, E; Tchavdarov, D; Usunoff, G | 1 |
| Barrada, O; Oftedal, SI | 1 |
| Vernadakis, A; Woodbury, DM | 1 |
| Hill, RG; Simmonds, MA; Straughan, DW | 1 |
| Hathway, DE; Mallinson, A | 1 |
| Bean, JW; Thom, B; Zee, D | 1 |
| Chusid, JG; Kopeloff, LM | 1 |
| Abrahams, DE; Wood, JD | 1 |
| Frank, GB; Jhamandas, K | 2 |
| Kimura, R; Murata, T | 1 |
| Selye, H | 1 |
| Andry, ML; Luttges, MW | 1 |
| Eichbaum, FW; Yasaka, J | 1 |
| Araki, Y; Ueki, S | 1 |
| Clarke, G; Hill, RG; Straughan, DW | 1 |
| Radomski, MW; Watson, WJ | 1 |
| Brown, DJ; Stone, WE | 1 |
| Baxter, MG; Miller, AA; Webster, RA | 1 |
| Goldstein, DB | 1 |
| Borowitz, JL; Sangiah, S; Yim, GK | 1 |
| Baker, WW; Kratky, M | 1 |
| Saito, S | 1 |
| Swinyard, EA | 1 |
| Tudor, I | 1 |
| Fujiwara, M; Matsuo, S; Shimamoto, K | 1 |
| Dadkar, NK; Damle, SK; Gaitonde, B | 1 |
| Yoshino, T | 1 |
| Elliott, KA; Yoshino, Y | 3 |
| Radomski, MW; Wood, JD | 1 |
| Hahn, F; May, HU | 1 |
| Hata, T; Kita, T; Murakami, T; Okage, T | 1 |
| Watson, WJ; Wood, JD | 1 |
| Ferngren, H | 1 |
| Adachi, S; Ishida, R; Kodama, T; Kowa, Y; Nishizawa, Y | 1 |
| Atsev, E; Chavdarov, D; Usunoff, G | 2 |
| Atsev, E; Chavdarov, D; Mihailov, S; Usunoff, G | 1 |
| Hahn, F; Kretzschmar, R; Meyer, HJ | 1 |
| Iwata, H; Oka, T; Shikimi, T | 1 |
| Kuriyama, K; Roberts, E; Rubinstein, MK | 1 |
9 review(s) available for picrotoxin and Seizures
| Article | Year |
|---|---|
Light-activated channels in acute seizures.
Topics: Animals; Bacterial Proteins; Convulsants; Electric Stimulation; Halorhodopsins; Hippocampus; Humans; Light; Luminescent Proteins; Membrane Potentials; Mice; Models, Biological; Organ Culture Techniques; Picrotoxin; Seizures; Transfection | 2011 |
Changes in CNS sensitivity to cannabinoids with repeated treatment: tolerance and auxoesthesia.
Topics: Animals; Brain; Cannabidiol; Cannabinoids; Dronabinol; Drug Tolerance; Electroshock; Kindling, Neurologic; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures | 1984 |
The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Bicuculline; Brain; Chlorides; Convulsants; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Picrotoxin; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures; Synaptic Membranes | 1981 |
Gamma hydroxybutyrate is not a GABA agonist.
Topics: 4-Butyrolactone; Animals; Central Nervous System; Convulsants; Electroencephalography; GABA Agonists; gamma-Aminobutyric Acid; Humans; Mammals; Muscle Contraction; Picrotoxin; Rabbits; Rats; Receptors, GABA; Respiration; Seizures; Sodium Oxybate | 1996 |
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Ganglia, Autonomic; Glycine; Humans; Isoniazid; Medulla Oblongata; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Receptors, Drug; Seizures; Sensory Receptor Cells; Spinal Cord; Strychnine; Substantia Nigra | 1975 |
Response of brain amino acids to drugs and environmental conditions.
Topics: Amino Acids; Aminobutyrates; Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Chlorpromazine; Environment; Ethanol; Glutamates; Guinea Pigs; Haloperidol; Hibernation; Hypoxia; Insulin; Mice; Picrotoxin; Rabbits; Rats; Reserpine; Seizures; Sleep | 1972 |
[Biochemistry of epilepsy].
Topics: Acetylcholine; Aminobutyrates; Animals; Brain; Electroencephalography; Epilepsy; Glutamates; Glutamine; Humans; Muscle Cramp; Pentylenetetrazole; Picrotoxin; Seizures | 1968 |
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; Electroshock; Humans; Methionine Sulfoximine; Methods; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine; Thiosemicarbazones; Trimethadione; Urea | 1969 |
[Biochemical aspects of seizures in convulsive diseases].
Topics: Ammonia; Animals; Biochemical Phenomena; Biochemistry; Cell Membrane; Epilepsy; Fatty Acids; Humans; Methionine; Nervous System; Neurons; Picrotoxin; Potassium; Seizures; Sodium; Strychnine | 1969 |
466 other study(ies) available for picrotoxin and Seizures
| Article | Year |
|---|---|
Neuro-pharmacological evaluation of anticonvulsant and neuroprotective activity of Cocculus laurifolius leaves in wistar rats.
Topics: Animals; Anticonvulsants; Apoptosis; Brain; Cocculus; Disease Models, Animal; Female; Male; Neurons; Neuroprotective Agents; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Seizures; Strychnine | 2019 |
GABA
Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy-Related Proteins; Brain Injuries, Traumatic; Disease Models, Animal; Epilepsy; Mice; Picrotoxin; Receptors, GABA-A; Seizures | 2022 |
Digoxin at sub-cardiotonic dose modulates the anticonvulsive potential of valproate, levetiracetam and topiramate in experimental primary generalized seizures.
Topics: Animals; Anticonvulsants; Camphor; Cardiotonic Agents; Digoxin; Levetiracetam; Male; Mice; Picrotoxin; Seizures; Strychnine; Topiramate; Valproic Acid | 2022 |
Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Arginine; Clerodendrum; Cyclooxygenase 2; Flumazenil; Guanosine Monophosphate; Kainic Acid; Lamiaceae; Methylene Blue; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Picrotoxin; Plant Extracts; Receptors, GABA-A; Seizures; Soluble Guanylyl Cyclase; Spasm | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Molecular Docking Simulation; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 2022 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin; Pilocarpine; Plant Extracts; Seizures; Strychnine; Water | 2023 |
The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin.
Topics: Animals; Calcineurin; Epilepsy; Mice; Picrotoxin; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Seizures | 2023 |
Noradrenergic stimulation of α
Topics: Animals; Mice; Norepinephrine; Picrotoxin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Seizures | 2023 |
Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists.
Topics: Animals; Brain; Bridged-Ring Compounds; Drug Evaluation, Preclinical; GABA-A Receptor Antagonists; Pentylenetetrazole; Picrotoxin; Seizures; Zebrafish | 2020 |
Potential Mechanisms Involved in the Anticonvulsant Effect of Methanol Extract of
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Methanol; Mice; Picrotoxin; Plant Extracts; Plants, Medicinal; Seizures; Toxicity Tests, Acute | 2020 |
Synthesis and Evaluation of Anticonvulsant Activity of Some Schiff Bases of 7-Amino-1,3-dihydro-2H-1,4-benzodiazepin-2-one.
Topics: Animals; Anticonvulsants; Azepines; Behavior, Animal; Female; Male; Models, Molecular; Molecular Structure; Picrotoxin; Rats; Rats, Wistar; Schiff Bases; Seizures | 2020 |
Sweet poison: seizures in two patients with
Topics: Adult; Female; Humans; Picrotoxin; Plants, Toxic; Seizures; Sesquiterpenes | 2021 |
Pharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Male; Medicine, Traditional; Mice; Mortality; Pentylenetetrazole; Picrotoxin; Plant Extracts; Ruta; Seizures | 2021 |
Electrophysiological field potential identification of an intact GABAergic system in mouse cortical slices.
Topics: Action Potentials; Animals; Brain; Electrophysiological Phenomena; gamma-Aminobutyric Acid; Mice, Inbred C57BL; Neurons; Picrotoxin; Seizures | 2021 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mice; Pentylenetetrazole; Phytochemicals; Picrotoxin; Plant Bark; Plant Extracts; Plant Stems; Psychotria; Rats, Wistar; Seizures; Semicarbazides; Sleep; Sleep Latency; Strychnine; Water | 2021 |
Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome.
Topics: Animals; Diazepam; Disease Models, Animal; Down Syndrome; Electrophysiological Phenomena; Female; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Picrotoxin; Seizures; Synaptic Transmission | 2021 |
Focal cortical seizures start as standing waves and propagate respecting homotopic connectivity.
Topics: Animals; Mice, Transgenic; Picrotoxin; Seizures; Visual Cortex | 2017 |
Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures.
Topics: Animals; Brain; Cells, Cultured; Convulsants; Cytokines; Disease Models, Animal; Gene Expression Regulation; Interleukin-10; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Nucleic Acids; Picrotoxin; RNA, Small Interfering; Seizures; Signal Transduction; STAT3 Transcription Factor | 2019 |
Rosmarinic acid improves oxidative stress parameters and mitochondrial respiratory chain activity following 4-aminopyridine and picrotoxin-induced seizure in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Cinnamates; Depsides; Disease Models, Animal; DNA Damage; Electron Transport Complex II; Hippocampus; Mice; Mitochondria; Neuroprotective Agents; Oxidative Stress; Picrotoxin; Rosmarinic Acid; Seizures | 2019 |
Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility.
Topics: Animals; Anticonvulsants; Behavior, Animal; Databases, Genetic; Electroencephalography; Enzyme Inhibitors; Feedback, Physiological; GABA Antagonists; Gene Expression Regulation, Enzymologic; Glutathione; Lactoylglutathione Lyase; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscarinic Agonists; Picrotoxin; Pilocarpine; Pyruvaldehyde; Receptors, GABA-A; Seizures; Status Epilepticus | 2013 |
Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; In Vitro Techniques; Magnesium; Male; MAP Kinase Signaling System; Picrotoxin; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Somatosensory Cortex | 2013 |
Seizure protection by intrapulmonary delivery of midazolam in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Routes; Kainic Acid; Male; Mice; Midazolam; Pentylenetetrazole; Picrotoxin; Seizures | 2013 |
Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures.
Topics: Acetamides; Animals; Brain; Catalase; Female; Lipid Peroxidation; Mice; Nitrites; Oxidative Stress; Pentylenetetrazole; Picrotoxin; Pilocarpine; Seizures; Strychnine | 2013 |
The effect of simvastatin on picrotoxin-induced seizure in mice.
Topics: Animals; Chi-Square Distribution; Hippocampus; Mice; Mice, Inbred BALB C; Picrotoxin; Pyramidal Cells; Random Allocation; Seizures; Simvastatin; Statistics, Nonparametric | 2012 |
Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; gamma-Aminobutyric Acid; Hypericum; Male; Medicine, Traditional; Mice; Nitric Oxide; Pentylenetetrazole; Picrotoxin; Plant Extracts; Seizures; Time Factors | 2013 |
Antisense reduction of tau in adult mice protects against seizures.
Topics: Age Factors; Animals; Anticonvulsants; Central Nervous System; Convulsants; Disease Models, Animal; Gait Disorders, Neurologic; Gene Expression Regulation; Infusions, Intraventricular; Lactic Acid; Locomotion; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Oligonucleotides, Antisense; Pentylenetetrazole; Picrotoxin; Seizures; tau Proteins | 2013 |
Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling.
Topics: Action Potentials; Animals; Anticonvulsants; Berberine Alkaloids; Carbamazepine; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Electrodes, Implanted; Finasteride; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Midazolam; Picrotoxin; Progesterone; Seizures | 2014 |
The analgesic and anticonvulsant effects of piperine in mice.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anticonvulsants; Benzodioxoles; Hot Temperature; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pentylenetetrazole; Picrotoxin; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Seizures | 2013 |
Comparison between the effect of propofol and midazolam on picrotoxin-induced convulsions in rat.
Topics: Administration, Intravenous; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Female; Midazolam; Picrotoxin; Propofol; Rats, Sprague-Dawley; Seizures; Time Factors | 2014 |
Evaluation of anticonvulsant actions of dibromophenyl enaminones using in vitro and in vivo seizure models.
Topics: Action Potentials; Animals; Anticonvulsants; CA1 Region, Hippocampal; Culture Media; Cyclohexanones; Cyclohexylamines; Electric Stimulation; Electroshock; Locomotion; Magnesium; Male; Microtomy; Phenytoin; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Tissue Culture Techniques | 2014 |
Synthesis, anticonvulsant, sedative and anxiolytic activities of novel annulated pyrrolo[1,4]benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Exploratory Behavior; Heterocyclic Compounds, 4 or More Rings; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Molecular Structure; Pentobarbital; Picrotoxin; Reflex, Abnormal; Seizures; Strychnine | 2014 |
Experimental investigation of pharmacodynamics and pharmacokinetics of carbamazepine nanoemulsion.
Topics: Animals; Anticonvulsants; Biological Availability; Blood-Brain Barrier; Diethylcarbamazine; Electric Stimulation; Emulsions; Male; Mice; Nanostructures; Picrotoxin; Seizures; Statistics, Nonparametric | 2014 |
Synthesis, anticonvulsant activity and molecular modeling study of some new hydrazinecarbothioamide, benzenesulfonohydrazide, and phenacylacetohydrazide analogues of 4(3H)-quinazolinone.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Hydrazines; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Picrotoxin; Quinazolinones; Seizures; Structure-Activity Relationship; Sulfonamides; Thiourea | 2015 |
Down-regulation of Homer1b/c protects against chemically induced seizures through inhibition of mTOR signaling.
Topics: Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; Down-Regulation; Glycine; Hippocampus; Homer Scaffolding Proteins; Maze Learning; Mice; PC12 Cells; Pentylenetetrazole; Phenylacetates; Phosphorylation; Picrotoxin; Rats; Receptor, Metabotropic Glutamate 5; Ribosomal Protein S6 Kinases; RNA Interference; Seizures; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
Hypersynchronous ictal onset in the perirhinal cortex results from dynamic weakening in inhibition.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cations, Monovalent; Cerebral Cortex; Excitatory Amino Acid Antagonists; GABA Antagonists; Neurons; Periodicity; Phosphinic Acids; Picrotoxin; Piperazines; Potassium; Propanolamines; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Seizures; Tissue Culture Techniques | 2016 |
NORADRENERGIC MECHANISMS IN THE PROCONVULSANT EFFECTS OF BUSPIRONE.
Topics: Animals; Anticonvulsants; Buspirone; Male; Mice; Picrotoxin; Receptors, Adrenergic, alpha-2; Seizures | 1999 |
Synthesis and Anticonvulsant Activity of N-(Substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Methaqualone; Mice; Pentylenetetrazole; Picrotoxin; Quinazolines; Seizures; Structure-Activity Relationship; Valproic Acid | 2016 |
Seizure termination by acidosis depends on ASIC1a.
Topics: Acid Sensing Ion Channels; Acidosis; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Carbon Dioxide; Electroencephalography; Female; Hippocampus; Hydrogen-Ion Concentration; Interneurons; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Knockout; Nerve Tissue Proteins; Patch-Clamp Techniques; Pentylenetetrazole; Picrotoxin; Seizures; Sodium Channels; Time Factors | 2008 |
GABA A receptor subtype selectivity underlying selective anxiolytic effect of baicalin.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Cell Line; Convulsants; Data Interpretation, Statistical; Electrophysiology; Flavonoids; Male; Mice; Mice, Inbred ICR; Patch-Clamp Techniques; Picrotoxin; Postural Balance; Radioligand Assay; Receptors, GABA-A; Seizures | 2008 |
Effect of optic and acoustic stimuli on the cortex and hypothalamus under conditions of picrotoxin convulsions.
Topics: Cerebral Cortex; Hypothalamus; Picrotoxin; Seizures | 1948 |
Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Cardiovascular System; Central Nervous System Stimulants; Cerebrovascular Circulation; Convulsants; Electroshock; Hypnotics and Sedatives; Kainic Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Seizures; Sleep; Theophylline; Thyrotropin; Thyrotropin-Releasing Hormone | 2009 |
Effects of extracts and neferine from the embryo of Nelumbo nucifera seeds on the central nervous system.
Topics: Animals; Anti-Anxiety Agents; Benzylisoquinolines; Body Temperature; Male; Mice; Mice, Inbred ICR; Motor Activity; Nelumbo; Phytotherapy; Picrotoxin; Plant Extracts; Rotarod Performance Test; Seeds; Seizures; Sleep; Strychnine | 2008 |
Anticonvulsant effects of the BK-channel antagonist paxilline.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Indoles; Mice; Mice, Inbred C57BL; Neocortex; Pentylenetetrazole; Picrotoxin; Potassium Channel Blockers; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Seizures; Time Factors | 2009 |
The action of pulse-modulated GSM radiation increases regional changes in brain activity and c-Fos expression in cortical and subcortical areas in a rat model of picrotoxin-induced seizure proneness.
Topics: Analysis of Variance; Animals; Brain; Disease Models, Animal; Electroencephalography; Gene Expression; Male; Picrotoxin; Proto-Oncogene Proteins c-fos; Radiation Dosage; Radio Waves; Rats; Rats, Sprague-Dawley; Seizures | 2009 |
Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Epilepsy, Generalized; Lethal Dose 50; Male; Methanol; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Plant Extracts; Plant Leaves; Polygalaceae; Seizures; Solvents; Water | 2008 |
Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Semicarbazones; Structure-Activity Relationship; Strychnine; Toxicity Tests | 2009 |
Effect of methanolic extract of Hyoscymus niger L. on the seizure induced by picritoxin in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Seeds; Seizures; Solanaceae | 2009 |
Synchronization of GABAergic inputs to CA3 pyramidal cells precedes seizure-like event onset in juvenile rat hippocampal slices.
Topics: Aging; Animals; CA3 Region, Hippocampal; Chlorides; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Intracellular Space; Magnesium Deficiency; Male; Periodicity; Picrotoxin; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Seizures; Synapses; Synaptic Transmission; Time Factors | 2009 |
Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Brain; Carbamazepine; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Entorhinal Cortex; Fructose; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Topiramate; Valproic Acid | 2010 |
Study of antiseizure effects of Matricaria recutita extract in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Matricaria; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Seizures; Survival Analysis; Survival Rate; Time Factors | 2009 |
Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parameters.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Electrophysiology; Electroshock; Ganglia, Spinal; Kainic Acid; Male; Mice; Motor Activity; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Statistics, Nonparametric; Thyrotropin-Releasing Hormone | 2009 |
Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Electrophoresis, Agar Gel; Enzyme Inhibitors; Finasteride; Indomethacin; Male; Mice; Neurons; Picrotoxin; Pregnanolone; Seizures | 2010 |
Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Apnea; Bronchodilator Agents; Child; Convulsants; Diazepam; Dizocilpine Maleate; Fever; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; Humans; Infant; Japan; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Picrotoxin; Purinergic P1 Receptor Agonists; Saccharomyces cerevisiae; Seizures | 2009 |
Evaluation of the anti-stress and anticonvulsant activities of leaf extract of Alchornea cordifolia in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Euphorbiaceae; Fatigue; Female; Male; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures; Stress, Psychological; Swimming | 2010 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbred Strains; Pakistan; Pentylenetetrazole; Phenytoin; Picrotoxin; Ranunculaceae; Seizures; Skin Neoplasms | 2010 |
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; GABA Modulators; gamma-Aminobutyric Acid; Organoselenium Compounds; Phenobarbital; Picrotoxin; Rats; Seizures | 2010 |
Anticonvulsant, anxiolytic and sedative activities of the aqueous root extract of Securidaca longepedunculata Fresen.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Hexobarbital; Hypnotics and Sedatives; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Picrotoxin; Plant Extracts; Plant Roots; Securidaca; Seizures; Sleep; Strychnine; Time Factors | 2010 |
Modeling seizure-related behavioral and endocrine phenotypes in adult zebrafish.
Topics: Animals; Behavior, Animal; Caffeine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Hydrocortisone; Locomotion; Male; Numerical Analysis, Computer-Assisted; Pentylenetetrazole; Phenotype; Picrotoxin; Reaction Time; Seizures; Statistics, Nonparametric; Zebrafish | 2010 |
Pharmacological characterization of GABAA receptors in taurine-fed mice.
Topics: Animals; Behavior, Animal; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mice; Picrotoxin; Receptors, GABA-A; Seizures; Taurine | 2010 |
GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity.
Topics: Animals; Connexins; Electroencephalography; Electrophysiological Phenomena; Etomidate; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junction delta-2 Protein; Gap Junctions; Hypnotics and Sedatives; In Vitro Techniques; Magnesium Deficiency; Male; Mefloquine; Mice; Mice, Inbred C57BL; Mice, Knockout; Picrotoxin; Receptors, GABA-A; Seizures | 2010 |
Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice.
Topics: Animals; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Ketones; Male; Mice; Motor Activity; Pentylenetetrazole; Phytotherapy; Picrotoxin; Piperidines; Plant Extracts; Plant Leaves; Seizures; Senna Plant | 2011 |
Investigation of Hypericum perforatum extract on convulsion induced by picrotoxin in mice.
Topics: Animals; Hypericum; Male; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2011 |
A study of neurotoxic biomarkers, c-fos and GFAP after acute exposure to GSM radiation at 900 MHz in the picrotoxin model of rat brains.
Topics: Animals; Behavior, Animal; Biomarkers; Brain; Cell Phone; Disease Models, Animal; Electromagnetic Radiation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Neurotoxicity Syndromes; Picrotoxin; Proto-Oncogene Proteins c-fos; Radiation Injuries; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 2011 |
Carbamazepine inhibits distinct chemoconvulsant-induced seizure-like activity in Dugesia tigrina.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Antagonists; N-Methylaspartate; Nicotine; Nicotinic Agonists; Oxcarbazepine; Picrotoxin; Planarians; Seizures; Structure-Activity Relationship | 2011 |
TASK Channel Deletion Reduces Sensitivity to Local Anesthetic-induced Seizures.
Topics: Anesthetics, Local; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Electroencephalography; Humans; Hydrogen-Ion Concentration; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Picrotoxin; Potassium Channels, Tandem Pore Domain; Seizures | 2011 |
Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders.
Topics: Acanthaceae; Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Female; Male; Medicine, African Traditional; Methanol; Mice; Nigeria; Phenobarbital; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures; Solvents; Strychnine | 2011 |
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Compounding; Drug Interactions; Epilepsy; Gas Chromatography-Mass Spectrometry; Lipid Peroxidation; Male; Manihot; Motor Activity; Muscarinic Agonists; Pentylenetetrazole; Phytotherapy; Picrotoxin; Pilocarpine; Plant Preparations; Random Allocation; Rats; Rats, Wistar; Seizures; Superoxide Dismutase | 2011 |
Human intravenous immunoglobulins suppress seizure activities and inhibit the activation of GFAP-positive astrocytes in the hippocampus of picrotoxin-kindled rats.
Topics: Animals; Astrocytes; CA1 Region, Hippocampal; CA2 Region, Hippocampal; Convulsants; Dentate Gyrus; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Immunoglobulins, Intravenous; Kindling, Neurologic; Male; Picrotoxin; Rats; Rats, Wistar; Seizures | 2012 |
Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed.
Topics: Animals; Anticonvulsants; Benzodiazepines; Central Nervous System; Central Nervous System Agents; Enzymes; Male; Mice; Phaeophyceae; Picrotoxin; Plant Extracts; Plants, Edible; Rats; Receptors, GABA-A; Seaweed; Seizures; Sleep; Tannins | 2012 |
Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine.
Topics: Animals; Astrocytes; Bridged-Ring Compounds; Calcium-Binding Proteins; Cerebral Cortex; Convulsants; Extremities; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Male; Mice; Microfilament Proteins; Microglia; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures | 2012 |
UPLC-TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ethanol; Female; Galium; Male; Mice; Motor Activity; Neuroprotective Agents; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Reaction Time; Seizures; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2012 |
Activity-dependent alternative splicing increases persistent sodium current and promotes seizure.
Topics: Alternative Splicing; Animals; Drosophila Proteins; Exons; gamma-Aminobutyric Acid; Membrane Potentials; Molecular Sequence Data; Mutant Proteins; Phenytoin; Picrotoxin; Ribonucleoproteins; Seizures; Sodium Channels; Synaptic Transmission | 2012 |
Combination of valproate and paroxetine in mice exposed to picrotoxin.
Topics: Animals; Anticonvulsants; Brain Chemistry; Drug Combinations; gamma-Aminobutyric Acid; Mice; Nucleus Accumbens; Paroxetine; Picrotoxin; Seizures; Selective Serotonin Reuptake Inhibitors; Thiobarbituric Acid Reactive Substances; Valproic Acid | 2012 |
Synthesis of some azoles incorporating a sulfonamide moiety as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Azoles; Convulsants; Drug Design; Mice; Molecular Structure; Picrotoxin; Seizures; Structure-Activity Relationship; Sulfonamides; Survival Analysis | 2012 |
Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana.
Topics: Animals; Anticonvulsants; Convulsants; Disaccharides; Flavonoids; Flavonols; Glycosides; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Motor Activity; Orchidaceae; Pentobarbital; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Sprague-Dawley; Seizures; Sleep Wake Disorders | 2002 |
Evidence for an involvement of nitric oxide and gamma aminobutyric acid in the anticonvulsant action of L-arginine on picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Arginine; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Nitric Oxide; Picrotoxin; Rats; Rats, Wistar; Seizures | 2002 |
Possible anxiolytic effects of ivermectin in rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Ivermectin; Locomotion; Male; Picrotoxin; Rats; Rats, Wistar; Seizures | 2002 |
An anticonvulsant profile of the ketogenic diet in the rat.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Bicuculline; Convulsants; Dietary Fats; Disease Models, Animal; Electroencephalography; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Strychnine; Survival Rate; Time Factors | 2002 |
Interaction of stress and noradrenergic drugs in the control of picrotoxin-induced seizures.
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Analysis of Variance; Animals; Benzylamines; Desipramine; Drug Interactions; Enzyme Inhibitors; GABA Antagonists; Male; Mice; Mice, Inbred CBA; Picrotoxin; Seizures; Stress, Physiological; Swimming | 2002 |
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
Topics: Animals; Anticonvulsants; Benzopyrans; Bicuculline; Cassia; Diazepam; Dopamine; Dose-Response Relationship, Drug; Male; Maze Learning; Methamphetamine; Pentylenetetrazole; Phenalenes; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Seizures; Sleep; Strychnine; Thiopental | 2002 |
Sex difference in susceptibility to picrotoxin-induced seizures in rats following octreotide.
Topics: Animals; Disease Susceptibility; Estrous Cycle; Female; Hormones; Male; Octreotide; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Sex Factors; Somatostatin | 2002 |
The effect of N-nitro-L-arginine methyl ester posttreatment on the anticonvulsant effect of phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Drug Synergism; Male; NG-Nitroarginine Methyl Ester; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures | 2003 |
5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Drugs, Chinese Herbal; Flavonoids; Ligands; Male; Maze Learning; Mice; Mice, Inbred ICR; Motor Activity; Picrotoxin; Plants, Medicinal; Psychomotor Performance; Radioligand Assay; Rats; Rats, Sprague-Dawley; Scutellaria baicalensis; Seizures | 2003 |
Increased neuronal nitric oxide synthase (nNOS) activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Brain; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indazoles; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Picrotoxin; Rats; Rats, Wistar; Seizures | 2003 |
Prevention of picrotoxin convulsions-induced learning and memory impairment by nitric oxide increasing dose of L-arginine in rats.
Topics: Animals; Arginine; Avoidance Learning; Convulsants; Dose-Response Relationship, Drug; Electroshock; Learning Disabilities; Male; Memory Disorders; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Picrotoxin; Psychomotor Performance; Rats; Rats, Wistar; Seizures | 2003 |
Long-term social isolation enhances picrotoxin seizure susceptibility in mice: up-regulatory role of endogenous brain allopregnanolone in GABAergic systems.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Male; Mice; Picrotoxin; Pregnanolone; Receptors, GABA-A; Seizures; Social Isolation; Time; Up-Regulation | 2003 |
Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L.
Topics: Animals; Anticonvulsants; Artemisia; Central Nervous System Agents; Convulsants; Ethanol; Gas Chromatography-Mass Spectrometry; Lethal Dose 50; Male; Mice; Oils, Volatile; Pentylenetetrazole; Picrotoxin; Pilocarpine; Plant Extracts; Plant Leaves; Postural Balance; Rats; Rats, Wistar; Seizures; Solvents; Strychnine | 2003 |
[Comparative action of products, numbers 3277 R.P., 4560 R.P., 4909 R.P. and of phenobarbital on convulsions induced by strychnine, picrotoxin, cocaine, cafeine and amphetamine].
Topics: Amphetamine; Amphetamines; Chlorpromazine; Cocaine; Histamine H1 Antagonists; Phenobarbital; Phenothiazines; Picrotoxin; Seizures; Strychnine | 1956 |
Strain differences in picrotoxin seizure threshold.
Topics: Learning; Picrotoxin; Seizures | 1962 |
[Comparative studies on the convulsive action of bemegrid, pentetrazol and picrotoxin].
Topics: Central Nervous System Stimulants; Pentylenetetrazole; Picrotoxin; Seizures | 1962 |
Circulation of cerebrospinal fluid in the spinal region of the cat.
Topics: Animals; Cats; Cerebrospinal Fluid; Picrotoxin; Seizures; Spinal Cord | 1962 |
FREE AMINO ACIDS AND RELATED COMPOUNDS IN DOG BRAIN: POST-MORTEM AND ANOXIC CHANGES, EFFECTS OF AMMONIUM CHLORIDE INFUSION, AND LEVELS DURING SEIZURES INDUCED BY PICROTOXIN AND BY PENTYLENETETRAZOL.
Topics: Amino Acids; Ammonium Chloride; Autopsy; Brain; Dogs; Hypoxia; Pathology; Pentylenetetrazole; Pharmacology; Picrotoxin; Proteins; Research; Seizures | 1963 |
[THE BIOELECTRIC ACTIVITY OF THE CENTRAL AND SYMPATHETIC NERVOUS SYSTEMS IN CAMPHOR, NICOTINE AND PICROTOXIN-INDUCED SEIZURES].
Topics: Autonomic Nervous System; Camphor; Electroencephalography; Ganglia; Ganglia, Autonomic; Hypothalamus; Nicotine; Pharmacology; Picrotoxin; Rabbits; Research; Seizures; Sympathetic Nervous System; Toxicology | 1963 |
STIMULANT ACTION OF PYRIDYL DERIVATIVES OF BENZODIOXANS AND BENZODIOXEPANS.
Topics: Animals; Anticonvulsants; Atropine; Bemegride; Central Nervous System Agents; Central Nervous System Stimulants; Chlorisondamine; Chlorpromazine; Diazepam; Mephenesin; Meprobamate; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Phenytoin; Picrotoxin; Research; Seizures; Strychnine; Tranquilizing Agents | 1963 |
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF PHENYL-SUBSTITUTED BIURETS.
Topics: Atropine; Biuret; Chemistry, Pharmaceutical; Gastric Juice; Meprobamate; Mice; Nicotine; Pentylenetetrazole; Peptic Ulcer; Pharmacology; Phenformin; Phenobarbital; Picrotoxin; Rats; Research; Seizures; Strychnine; Toxicology; Urea | 1963 |
THE ACTION OF SODIUM 4-HYDROXYBUTYRATE ON SPINAL REFLEXES.
Topics: Aminobutyrates; Anesthesia; Anesthesia, Local; Anesthesiology; Animals; Blood Pressure Determination; Cats; Diaphragm; gamma-Aminobutyric Acid; Hydroxybutyrates; Injections, Intraperitoneal; Injections, Intravenous; Meprobamate; Mice; Nervous System Physiological Phenomena; Neuromuscular Junction; Pharmacology; Phrenic Nerve; Picrotoxin; Poultry; Rats; Reflex; Research; Seizures; Sodium; Sodium Oxybate; Spinal Cord; Strychnine; Swine; Toxicology | 1964 |
THE HISTOMORPHOLOGY OF EXPERIMENTAL EXCITATION.
Topics: Acridines; Coloring Agents; Depression; Depressive Disorder; Hippocampus; Histology; Lysergic Acid Diethylamide; Neuroglia; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Research; Seizures; Staining and Labeling; Toxicology | 1964 |
HISTOLOGICAL CHANGES IN STRUCTURAL CONSTITUENTS OF SPINAL MOTONEURONS AFTER PICROTOXIN, STRYCHNINE AND TETANUS TOXIN ADMINISTRATION.
Topics: Motor Neurons; Pathology; Picrotoxin; Rats; Research; Seizures; Spinal Cord; Strychnine; Tetanus Toxin; Toxicology | 1964 |
THE DISTRIBUTION OF GAMMA-AMINOBUTYRIC ACID IN THE MONKEY BRAIN DURING PICROTOXIN-INDUCED SEIZURES.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Chromatography; gamma-Aminobutyric Acid; Glutamates; Haplorhini; Metabolism; Parietal Lobe; Picrotoxin; Research; Seizures; Toxicology | 1964 |
CARDIAC EFFECTS OF DIMEFLINE COMPARED WITH THOSE OF OTHER CENTRAL NERVOUS SYSTEM STIMULANTS.
Topics: Aminobutyrates; Bemegride; Benzene; Calcium; Central Nervous System Stimulants; Chlorides; Coronary Vessels; Electrocardiography; Epinephrine; Flavones; Flavonoids; Guinea Pigs; Heart; Nikethamide; Pentylenetetrazole; Pharmacology; Picrotoxin; Research; Seizures; Strychnine; Toxicology; Ventricular Fibrillation | 1964 |
EFFECTS OF DIELDRIN, PICROTOXIN AND TELODRIN ON THE METABOLISM OF AMMONIA IN BRAIN.
Topics: Alanine; Amino Acids; Ammonia; Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Dieldrin; Furans; Glutamic Acid; Glutamine; Lactates; Metabolism; Pharmacology; Picrotoxin; Rats; Seizures | 1965 |
THE EFFECT OF PICROTOXIN ON MOTOR ACTIVITY AND THE ELECTROENCEPHALOGRAM OF MICE.
Topics: Amphetamine; Amphetamines; Animals; Bemegride; Blood Pressure; Dextroamphetamine; Electroencephalography; Electrophysiology; Injections, Intravenous; Mice; Motor Activity; Motor Neurons; Movement; Pharmacology; Picrotoxin; Research; Seizures | 1965 |
Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Carrier Proteins; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; Genetic Predisposition to Disease; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Seizures | 2003 |
Developmental characteristics of picrotoxin-induced convulsions in rats with genetic absence epilepsy.
Topics: Aging; Animals; Brain; Convulsants; Electroencephalography; Epilepsy, Absence; GABA Antagonists; GABA-A Receptor Antagonists; Picrotoxin; Rats; Rats, Wistar; Seizures | 2003 |
Demonstrating the dose- and time-related effects of 7-nitroindazole on picrotoxin-induced convulsions, memory formation, brain nitric oxide synthase activity, and nitric oxide concentration in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Indazoles; Male; Memory; Nitric Oxide; Nitric Oxide Synthase; Picrotoxin; Rats; Rats, Wistar; Seizures; Time Factors | 2004 |
Inhibitory effects of the essential oil from SuHeXiang Wan on the central nervous system after inhalation.
Topics: 4-Aminobutyrate Transaminase; Administration, Inhalation; Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Drugs, Chinese Herbal; Glutamic Acid; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Oils, Volatile; Pentylenetetrazole; Phytotherapy; Picrotoxin; Receptors, GABA-A; Seizures; Sleep; Strychnine | 2004 |
Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol.
Topics: Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Carbolines; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Flutamide; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Picrotoxin; Receptors, Androgen; Receptors, GABA-A; Seizures; Testosterone | 2004 |
Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Indazoles; Male; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures | 2003 |
Reversal of hippocampal LTP by spontaneous seizure-like activity: role of group I mGluR and cell depolarization.
Topics: Animals; Bicuculline; Calcium; Dendrites; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Membrane Potentials; Models, Neurological; Neurons; Picrotoxin; Receptors, Metabotropic Glutamate; Seizures; Synaptic Transmission; Time Factors | 2005 |
Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine.
Topics: Alanine; Amino Acids; Animals; Bicuculline; Convulsants; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Male; Mice; Microinjections; N-Methylaspartate; Picrotoxin; Pregnenolone; Seizures | 2004 |
The effect of L-arginine on the memory impairing action of phenobarbitone in rats that convulsed after the injection of picrotoxin.
Topics: Animals; Arginine; Male; Memory Disorders; Nitric Oxide; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures | 2004 |
Influence of seizures on lipids of homogenate and neuronal and glial nuclei of rat neocortex.
Topics: Animals; Cell Nucleus; Convulsants; DNA; Lipid Metabolism; Lysophosphatidylcholines; Male; Microscopy, Electron; Neocortex; Neuroglia; Neurons; Nuclear Proteins; Picrotoxin; Rats; Seizures; Sphingomyelins | 2004 |
Free radical lipid oxidation in brain cortex neurons and neuroglia during convulsions.
Topics: Animals; Cerebral Cortex; Convulsants; Free Radicals; Lipid Peroxidation; Male; Neuroglia; Neurons; Picrotoxin; Rats; Seizures | 2004 |
Anticonvulsant effects of acute and repeated fluoxetine treatment in unstressed and stressed mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Fluoxetine; Hindlimb; Male; Mice; Mice, Inbred CBA; Picrotoxin; Seizures; Stress, Psychological; Swimming | 2005 |
Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices.
Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Caseins; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Fetal Nutrition Disorders; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Lactation; Male; Picrotoxin; Pregnancy; Prenatal Nutritional Physiological Phenomena; Quinolinic Acid; Rats; Seizures; Time Factors; Tritium | 2005 |
Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; gamma-Aminobutyric Acid; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures | 2005 |
The effects of L-DOPA and transcranial magnetic stimulation on behavioral reactions in kindled rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dopamine Agents; Electric Stimulation; Electromagnetic Fields; Epilepsy; Exploratory Behavior; Feeding Behavior; Female; Kindling, Neurologic; Levodopa; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Sexual Behavior, Animal | 2005 |
Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hippocampus; Male; Microdialysis; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures | 2005 |
Abolition of spindle oscillations and 3-Hz absence seizurelike activity in the thalamus by using high-frequency stimulation: potential mechanism of action.
Topics: Action Potentials; Animals; Deep Brain Stimulation; Epilepsy; Essential Tremor; Female; Ferrets; GABA Antagonists; Male; Neurons; Neurotransmitter Agents; Parkinson Disease; Periodicity; Picrotoxin; Seizures; Synaptic Membranes; Thalamus | 2005 |
Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist.
Topics: Animals; Behavior, Animal; Benzodiazepines; Carbolines; Convulsants; Dose-Response Relationship, Drug; Male; Picrotoxin; Rats; Rats, Wistar; Seizures | 2005 |
Stimulation of 5-HT 1A receptors increases the seizure threshold for picrotoxin in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Drug Administration Schedule; Drug Therapy, Combination; Ketanserin; Male; Mice; Mice, Inbred CBA; Picrotoxin; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Seizures; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Stress, Physiological; Swimming | 2005 |
Picrotoxin-induced convulsions alters rat brain microsomal membrane structural properties.
Topics: Animals; Brain; Cholesterol; Disease Models, Animal; Male; Membranes; Microsomes; Phospholipids; Picrotoxin; Rats; Seizures | 2006 |
Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Bicuculline; Female; Fruit; Hot Temperature; Male; Mice; Mice, Inbred BALB C; Pain; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures; Tetrapleura | 2005 |
GSM radiation triggers seizures and increases cerebral c-Fos positivity in rats pretreated with subconvulsive doses of picrotoxin.
Topics: Animals; Brain; Cell Phone; Convulsants; Male; Microwaves; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures | 2006 |
Nifedipine inhibits picrotoxin-induced seizure activity: further evidence on the involvement of L-type calcium channel blockers in epilepsy.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Convulsants; Dose-Response Relationship, Drug; Female; Nifedipine; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures | 2006 |
Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Ethanol; Flumazenil; Flurothyl; GABA Antagonists; GABA-A Receptor Antagonists; Gerbillinae; Male; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 2006 |
Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action.
Topics: Animals; Bicuculline; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Muscimol; Picrotoxin; Seizures | 2006 |
Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents.
Topics: Action Potentials; Acyclic Monoterpenes; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Mice; Monoterpenes; Neural Conduction; Pentylenetetrazole; Picrotoxin; Reaction Time; Seizures; Time Factors | 2006 |
Seizures induced by in vivo latrunculin a and jasplakinolide microperfusion in the rat hippocampus.
Topics: Actins; Animals; Anticonvulsants; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Depsipeptides; Hippocampus; Male; Microdialysis; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Thiazolidines | 2006 |
Zimelidine decreases seizure susceptibility in stressed mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Ketanserin; Male; Mianserin; Mice; Mice, Inbred CBA; Phenols; Picrotoxin; Piperazines; Pyridines; Seizures; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Stress, Psychological; Sulfonamides; Swimming; Zimeldine | 2006 |
Blockade of inhibitory neurotransmission evoked seizure-like firing of cardiac parasympathetic neurons in brainstem slices of newborn rats: Implications for sudden deaths in patients of epilepsy.
Topics: Animals; Animals, Newborn; Arrhythmias, Cardiac; Brain Stem; Cerebrospinal Fluid; Death, Sudden, Cardiac; GABA Antagonists; Glycine Agents; Neurons; Parasympathetic Nervous System; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Strychnine; Synaptic Transmission | 2006 |
Anticonvulsant effect of Persea americana Mill (Lauraceae) (Avocado) leaf aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Lethal Dose 50; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Persea; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures | 2006 |
In vivo characterization of sedative activities of Fossilia Mastodi OSSIS.
Topics: Animals; Diazepam; Fossils; Hypnotics and Sedatives; Male; Mammals; Mice; Mice, Inbred ICR; Motor Activity; Pentobarbital; Picrotoxin; Seizures; Sleep; Tissue Extracts | 2006 |
Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission.
Topics: Animals; Antidepressive Agents; Binding, Competitive; Carbon Dioxide; Central Nervous System; Cerebellum; Depression, Chemical; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Humulus; Male; Maze Learning; Motor Activity; Pentobarbital; Picrotoxin; Plant Extracts; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sleep; Solvents; Swimming; Synaptic Transmission | 2007 |
Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats.
Topics: Administration, Oral; Animals; Anticonvulsants; Behavior, Animal; Dibenzazepines; Disease Models, Animal; Electroencephalography; Hippocampus; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures | 2006 |
Development of a Drosophila seizure model for in vivo high-throughput drug screening.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Cell Survival; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila; Drug Evaluation, Preclinical; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; Larva; Pentylenetetrazole; Phenotype; Phenytoin; Picrotoxin; Seizures | 2006 |
Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.
Topics: Analgesics; Animals; Anticonvulsants; Benzhydryl Compounds; Benzyl Compounds; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hot Temperature; Male; Mice; Molecular Structure; Motor Activity; Pain Measurement; Pain Threshold; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Receptors, Purinergic P1; Seizures; Structure-Activity Relationship; Urea | 2007 |
Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Crassulaceae; Dose-Response Relationship, Drug; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures | 2007 |
Effects of postnatal caffeine exposure on seizure susceptibility in developing rats.
Topics: Age Factors; Aminophylline; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Disease Susceptibility; Drug Interactions; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Severity of Illness Index | 2007 |
Optical suppression of seizure-like activity with an LED.
Topics: Animals; Anticonvulsants; Calcium; Cells, Cultured; Electrophysiology; Epilepsies, Partial; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Mice; Microscopy, Fluorescence; Neurons; Picrotoxin; Seizures; Ultraviolet Rays | 2007 |
Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm ('African potato') aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Hypoxis; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2008 |
Pro-convulsant effect of cefazolin sodium against pentylenetetrazol- or picrotoxin-induced convulsions in mice.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Cefazolin; Convulsants; GABA-A Receptor Agonists; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures | 2007 |
Interaction of diazepam and swim stress.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Mice; Picrotoxin; Pregnanolone; Reaction Time; Seizures; Stress, Psychological; Swimming | 2007 |
Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mice; Oils, Volatile; Pentylenetetrazole; Phenytoin; Phytotherapy; Picrotoxin; Plant Leaves; Plant Oils; Poaceae; Seizures; Strychnine | 2008 |
A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Chromatography, Thin Layer; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glycine; Mice; Mice, Inbred BALB C; Phytotherapy; Picrotoxin; Plant Preparations; Seizures; Vicia faba | 2008 |
Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, Liquid; Disease Models, Animal; Dopamine; Electroencephalography; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Methoxyhydroxyphenylglycol; Microdialysis; Picrotoxin; Pilocarpine; Rats; Rats, Wistar; Seizures; Serotonin; Statistics, Nonparametric; Time Factors | 2008 |
Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract.
Topics: Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Mice; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2008 |
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; Drug Interactions; Finasteride; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Oxazines; Picrotoxin; Pregnanolone; Progesterone; Receptors, GABA-A; Restraint, Physical; Seizures; Stress, Psychological | 2008 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; Electroshock; Enzyme Inhibitors; Epilepsy; gamma-Aminobutyric Acid; Gerbillinae; Magnesium; Male; Mice; Mice, Inbred BALB C; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution | 2008 |
Some correlations between picrotoxin-induced seizures and gamma-aminobutyric acid in animal brain.
Topics: Aminobutyrates; Animals; Diencephalon; Epinephrine; Female; In Vitro Techniques; Male; Mesencephalon; Mice; Norepinephrine; Picrotoxin; Rabbits; Seizures | 1967 |
Delay or inhibition of convulsions by intraperitoneal injections of diverse substances.
Topics: Alanine; Aminobutyrates; Animals; Atmospheric Pressure; Brain Chemistry; Hypertonic Solutions; Injections, Intraperitoneal; Male; Organ Size; Oxygen; Pentylenetetrazole; Picrotoxin; Potassium; Rats; Seizures; Sodium; Sodium Chloride; Strychnine; Succinates; Sucrose; Urea | 1967 |
Effect of anticonvulsants on picrotoxin induced flaccid stationary posture in mice.
Topics: Animals; Anticonvulsants; Female; Mice; Picrotoxin; Seizures | 1967 |
Inhibition of seizures induced by picrotoxin and electroshock by cholecystokinin octapeptides and their fragments in rats after intracerebroventricular administration.
Topics: Animals; Anticonvulsants; Diazepam; Electroshock; Injections, Intraventricular; Male; Peptide Fragments; Picrotoxin; Rats; Seizures; Sincalide | 1984 |
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Tolerance; Isoquinolines; Ligands; Male; Mice; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Strychnine | 1984 |
Interaction between delta-9-tetrahydrocannabinol and kindling by electrical and chemical stimuli in mice.
Topics: Animals; Dronabinol; Drug Interactions; Electric Stimulation; Electroshock; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Stimulation, Chemical; Time Factors | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stress, Physiological; Thiosemicarbazones | 1980 |
Effect of repeated electroconvulsive shocks (ECS) on subthreshold doses of some CNS stimulants.
Topics: Animals; Central Nervous System Stimulants; Electroshock; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1980 |
Dihydropicrotoxinin binding sites in mammalian brain: interaction with convulsant and depressant benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Brain; gamma-Aminobutyric Acid; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures; Stereoisomerism | 1981 |
Behavior during hippocampal microinfusions. IV. Transmitter interactions.
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Exploratory Behavior; gamma-Aminobutyric Acid; Hippocampus; Male; Motor Activity; Neurotransmitter Agents; Norepinephrine; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1982 |
Dose-dependence of the effect of hydralazine on the central nervous system in rats.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Hydralazine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1983 |
Modification of seizures elicited by the benzodiazepine Ro 5-3663--a comparison with picrotoxin.
Topics: Animals; Benzodiazepinones; Chemical Phenomena; Chemistry; Convulsants; Diazepam; Drug Synergism; Flumazenil; Male; Mice; Picrotoxin; Pyrazoles; Quinolines; Seizures | 1984 |
Halothane effect on cGMP and control of motor activity in mouse cerebellum.
Topics: Animals; Cerebellum; Cyclic GMP; Halothane; Isoniazid; Male; Mice; Motor Activity; Picrotoxin; Seizures; Strychnine | 1981 |
Interactions between cholinergic drugs, gamma-aminobutyric acid and cyclic guanosine monophosphate on picrotoxin-induced convulsive-seizure threshold.
Topics: Animals; Cyclic GMP; Dibutyryl Cyclic GMP; Drug Interactions; gamma-Aminobutyric Acid; Mice; Oxotremorine; Parasympathomimetics; Picrotoxin; Seizures | 1981 |
Specific proconvulsant action of an imidazobenzodiazepine (RO 15-1788) on isoniazid convulsions.
Topics: Animals; Benzodiazepinones; Brain; Convulsants; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; Isoniazid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Seizures | 1982 |
Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling).
Topics: Animals; Bicuculline; Electroshock; GABA Antagonists; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures | 1982 |
Antagonism of GABA-mediated responses by d-tubocurarine in hippocampal neurons.
Topics: Animals; Bicuculline; Culture Techniques; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Neural Inhibition; Neurons; Picrotoxin; Receptors, Adrenergic, beta; Seizures; Synapses; Synaptic Transmission; Tetrodotoxin; Tubocurarine | 1982 |
Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes.
Topics: Animals; Behavior, Animal; Bicuculline; Body Temperature Regulation; Dose-Response Relationship, Drug; Ethanol; Female; Motor Activity; Muridae; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Sleep Stages; Strychnine | 1982 |
Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments.
Topics: 3-Mercaptopropionic Acid; Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Brain; Cell Compartmentation; Cell Fractionation; Cerebellum; Drug Interactions; Female; gamma-Aminobutyric Acid; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Synaptosomes | 1983 |
Structure-activity and dose-effect relationships of the antagonism of picrotoxin-induced seizures by cholecystokinin, fragments and analogues of cholecystokinin in mice.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Male; Mice; Peptide Fragments; Picrotoxin; Seizures; Sincalide; Structure-Activity Relationship | 1983 |
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Convulsants; Dose-Response Relationship, Drug; Flumazenil; Lorazepam; Male; Muridae; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
Proconvulsant action of CGS 8216.
Topics: Animals; Benzodiazepinones; Convulsants; Drug Synergism; Flumazenil; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrazoles; Seizures | 1983 |
Effect of dihydroergotoxine on the susceptibility of rats to convulsions produced by different convulsant agents.
Topics: Animals; Bicuculline; Convulsants; Dihydroergotoxine; Drug Synergism; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1983 |
Facilitation of diazepam action by anticonvulsant agents against picrotoxin induced convulsions.
Topics: Animals; Anticonvulsants; Diazepam; Female; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1983 |
Effect of prostaglandin synthetase inhibitors on experimentally induced convulsions in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Cyclooxygenase Inhibitors; Electroshock; Female; Hindlimb; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Differential effects of picrotoxin- and pentylenetetrazol-induced convulsions on the secretion of luteinizing hormone and follicle-stimulating hormone in rats.
Topics: Animals; Calcium; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Male; Pentylenetetrazole; Picrotoxin; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Seizures | 1984 |
[Effect of nootropic agents on the lowering of the spasm threshold after a single ethanol application].
Topics: Animals; Brain; Ethanol; Male; Meclofenoxate; Meglumine; Mice; Orotic Acid; Picrotoxin; Piracetam; Pyrithioxin; Seizures; Spasm; Time Factors | 1984 |
[Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin].
Topics: Animals; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Valproic Acid | 1981 |
Increased sensitivity to picrotoxin as an index of physical dependence on alcohol in the mouse.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Dose-Response Relationship, Drug; Humans; Lethal Dose 50; Male; Mice; Picrotoxin; Psychoses, Alcoholic; Pyrazoles; Reaction Time; Seizures | 1984 |
Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Functional anatomy of limbic seizures: focal discharges from medial entorhinal cortex in rat.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Deoxyglucose; Electric Stimulation; Hippocampus; Male; Penicillins; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Temporal Lobe | 1983 |
Morphine potentiates seizures induced by GABA antagonists and attenuates seizures induced by electroshock in the rat.
Topics: Animals; Bicuculline; Drug Synergism; Electroshock; GABA Antagonists; Isoniazid; Male; Morphine; Naloxone; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1983 |
Effect of phenoxybenzamine on the GABA system and on convulsive activity.
Topics: Aminooxyacetic Acid; Animals; Behavior, Animal; Brain Chemistry; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Phenoxybenzamine; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Tissue Distribution | 1983 |
Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile.
Topics: Animals; Anticonvulsants; Electroencephalography; Electroshock; Female; Imidazoles; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Procaine; Rabbits; Rats; Rats, Inbred Strains; Seizures; Species Specificity | 1983 |
Interactions of two phenylquinolines with picrotoxin and benzodiazepines in vivo and in vitro.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Myoclonus; Pentylenetetrazole; Picrotoxin; Quinolines; Rats; Rats, Inbred Strains; Seizures | 1984 |
Effects of intracellular injections of chloride and EGTA on postepileptiform-burst hyperpolarizations in hippocampal neurons.
Topics: Animals; Chlorides; Egtazic Acid; Ethylene Glycols; Guinea Pigs; Hippocampus; Neurons; Penicillins; Picrotoxin; Seizures | 1981 |
Convulsant-specific architecture of the postictal behavior syndrome in the rat.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Catatonia; Convulsants; Disease Models, Animal; Electroshock; Epilepsy, Tonic-Clonic; Female; Humans; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1981 |
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.
Topics: Acoustic Stimulation; Aggression; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; Humans; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1982 |
Pharmacological investigation of convulsant gamma-aminobutyric acid (GABA) antagonists in amygdala-kindled rats.
Topics: Amygdala; Animals; Convulsants; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1982 |
Further characterization of the behavioral despair test in mice: positive effects of convulsants.
Topics: Animals; Antidepressive Agents; Bicuculline; Brain; Convulsants; Dextroamphetamine; Escape Reaction; Male; Mice; Motivation; Motor Activity; Muridae; Picrotoxin; Seizures; Sleep, REM; Strychnine | 1982 |
Anticonvulsant effects of muscimol.
Topics: Animals; Bicuculline; GABA Antagonists; Muscimol; Neurons; Oxazoles; Penicillins; Picrotoxin; Rats; Receptors, Drug; Seizures; Strychnine | 1980 |
Muscimol-induced myoclonic jerks in mice.
Topics: Animals; Drug Interactions; Kinetics; Male; Mice; Muscimol; Oxazoles; Picrotoxin; Seizures | 1981 |
Behavioural effects of GABA-agonists and antagonists infused in the mesencephalic reticular formation - deep layers of superior colliculus.
Topics: Animals; Behavior, Animal; Bicuculline; Dominance, Cerebral; gamma-Aminobutyric Acid; Mesencephalon; Motor Activity; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Reticular Formation; Seizures; Superior Colliculi | 1981 |
Pharmacologic analysis of the postictal immobility syndrome in the rat.
Topics: Animals; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Female; Haloperidol; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1981 |
Dihydroergotoxine and the Seizure Threshold.
Topics: Allylglycine; Animals; Brain Chemistry; Catecholamines; Dihydroergotoxine; Drug Interactions; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1981 |
Pharmacological investigation of gamma aminobutyric acid (GABA) and the development of amygdala-kindled seizures in the rat.
Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Aminocaproates; Amygdala; Animals; Bicuculline; gamma-Aminobutyric Acid; Imidazoles; Kindling, Neurologic; Male; Pentobarbital; Picrotoxin; Rats; Seizures; Vigabatrin | 1981 |
Amygdaloid kindling and the GABA system.
Topics: 4-Aminobutyrate Transaminase; Amygdala; Animals; Electric Stimulation; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Seizures; Transaminases | 1980 |
Picrotoxin convulsions involve synaptic and nonsynaptic mechanisms on cultured mouse spinal neurons.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Magnesium; Membrane Potentials; Mice; Picrotoxin; Seizures; Spinal Cord; Synapses | 1980 |
Effects of anticonvulsants and glutamate antagonists on the convulsive action of kainic acid.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bemegride; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrrolidines; Seizures | 1980 |
Locomotor and convulsive responses to picrotoxin in amygdala-kindled rats.
Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Electric Stimulation; gamma-Aminobutyric Acid; Locomotion; Male; Picrotoxin; Rats; Seizures | 1980 |
Effects of barbital or diazepam withdrawal on seizure thresholds to bicuculline, picrotoxin and flurazepam.
Topics: Animals; Barbital; Bicuculline; Convulsants; Diazepam; Flurazepam; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome | 1995 |
Distribution of Fos-positive neurons in cortical and subcortical structures after picrotoxin-induced convulsions varies with seizure type.
Topics: Animals; Behavior, Animal; Cell Count; Cerebral Cortex; Coloring Agents; Electroencephalography; Immunohistochemistry; Infusions, Intravenous; Male; Neurons; Pentobarbital; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
[The effect of the intranigral use of the delta sleep-inducing peptide and its analogs on the motor and seizure activities of rats].
Topics: Animals; Anticonvulsants; Delta Sleep-Inducing Peptide; Drug Evaluation, Preclinical; Male; Microinjections; Motor Activity; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Substantia Nigra | 1995 |
Effects of propofol and thiopentone on picrotoxin convulsive threshold in the rabbit.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Picrotoxin; Propofol; Rabbits; Seizures; Thiopental | 1995 |
2,3-Butanedione monoxime protects mice against the convulsant effect of picrotoxin by facilitating GABA-activated currents.
Topics: Animals; Anticonvulsants; Cholinesterase Reactivators; Diacetyl; Dose-Response Relationship, Drug; Hypothalamus; Male; Mice; Picrotoxin; Receptors, GABA; Seizures | 1995 |
Seizure-protecting effects of kyotorphin and related peptides in an animal model of epilepsy.
Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Endorphins; Hippocampus; Injections; Injections, Intraventricular; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Stereoisomerism; Substantia Nigra | 1995 |
Neonatal caffeine exposure and seizure susceptibility in adult rats.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Caffeine; Female; Kainic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Receptors, Purinergic P1; Seizures; Sex Factors; Strychnine | 1995 |
Central nervous system activity of Rhazya stricta (Decne) in mice.
Topics: Abdomen; Analgesia; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Cimetidine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Hypnotics and Sedatives; Male; Medicine, Arabic; Mice; Motor Activity; Naloxone; Pentobarbital; Picrotoxin; Plant Extracts; Plant Leaves; Plants, Medicinal; Seizures; Sleep; Tail | 1995 |
Effects of 1-amino-5-bromouracil on the benzodiazepine-GABAA receptor complex.
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bromouracil; Convulsants; Dehydroepiandrosterone; Male; Mice; Mice, Inbred ICR; Muscimol; Picrotoxin; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Seizures; Synaptic Membranes | 1994 |
Evolution of afterdischarge and seizure characteristics during electrical kindling of the guinea-pig.
Topics: Animals; Behavior, Animal; Electric Stimulation; Electroencephalography; Electrophysiology; Female; Guinea Pigs; Kindling, Neurologic; Male; Movement; Neural Inhibition; Picrotoxin; Reserpine; Seizures; Time Factors | 1995 |
[Involvement of GABAergic and NMDA systems in drug-induced convulsions in mice].
Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channels; Chloride Channels; Male; Mice; Mice, Inbred Strains; Muscimol; Phenobarbital; Picrotoxin; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists.
Topics: Analysis of Variance; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Electroshock; Escape Reaction; Flumazenil; GABA-A Receptor Agonists; Hippocampus; Male; Picrotoxin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sesterterpenes; Stress, Psychological; Strychnine; Sulfur Radioisotopes; Tritium | 1994 |
On the mechanism of antiepileptic peptides appearance in the cerebrospinal fluid.
Topics: Animals; Anticonvulsants; Cats; Cerebellum; Electroshock; Male; Peptides; Picrotoxin; Rats; Rats, Wistar; Seizures; Superior Colliculi | 1994 |
Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats.
Topics: Animals; Cerebral Cortex; Differential Threshold; Electroencephalography; Electronic Data Processing; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurons; Pentylenetetrazole; Picrotoxin; Pyridoxine; Rats; Rats, Sprague-Dawley; Seizures; Thalamus; Vitamin B 6 Deficiency | 1994 |
Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice.
Topics: Administration, Oral; Animals; Anticonvulsants; Bemegride; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Electroshock; Female; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Seizures | 1994 |
Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Histamine Agonists; Histamine Antagonists; Histamine H1 Antagonists; Male; Mice; Mice, Neurologic Mutants; Pentylenetetrazole; Picrotoxin; Receptors, Histamine H3; Seizures | 1994 |
[Central inhibition action of Valeriana jatamansii Jones].
Topics: Analgesics; Animals; Anticonvulsants; Drug Synergism; Drugs, Chinese Herbal; Female; Hypnotics and Sedatives; Male; Mice; Pentobarbital; Picrotoxin; Seizures; Semicarbazides | 1994 |
Effects of valine, leucine, isoleucine, and a balanced amino acid solution on the seizure threshold to picrotoxin in rats.
Topics: Amino Acids; Amino Acids, Branched-Chain; Animals; Injections, Intraperitoneal; Isoleucine; Leucine; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Valine | 1994 |
Effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Endothelins; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1994 |
A technique for quantitative measurement of clonic convulsions in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Monitoring, Physiologic; Picrotoxin; Rats; Rats, Wistar; Seizures | 1994 |
Effects of an N-methyl-D-aspartate antagonist and a GABAergic antagonist on entorhinal tetanic responses during the early stages of amygdala kindling in rats.
Topics: Amygdala; Animals; Electrophysiology; GABA Antagonists; Kindling, Neurologic; Limbic System; Male; N-Methylaspartate; Picrotoxin; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures | 1994 |
Picrotoxin-induced seizures modified by morphine and opiate antagonists.
Topics: Animals; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Male; Morphine; Motor Activity; MSH Release-Inhibiting Hormone; Narcotic Antagonists; Picrotoxin; Rats; Seizures | 1993 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; Mice; Muscimol; Phenobarbital; Phenytoin; Picrotoxin; Receptors, GABA; Seizures; Strychnine | 1993 |
Behavioural and biochemical changes produced by repeated oral administration of the insecticide endosulfan in immature rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Behavior, Animal; Body Weight; Eating; Endosulfan; Growth; Male; Motor Activity; Organ Size; Picrotoxin; Postural Balance; Proteins; Rats; Rats, Wistar; Seizures | 1993 |
Picrotoxin-induced behavioral tolerance and altered susceptibility to seizures: effects of naloxone.
Topics: Animals; Behavior, Animal; Drug Tolerance; Epilepsies, Myoclonic; Epilepsies, Partial; Kindling, Neurologic; Male; Motor Activity; Naloxone; Picrotoxin; Rats; Seizures | 1993 |
Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures.
Topics: Amphetamine; Animals; Antidepressive Agents; Bupropion; Desipramine; Male; Mice; N-Methylaspartate; Picrotoxin; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Zimeldine | 1993 |
The anticonvulsant effects of propofol, diazepam, and thiopental, against picrotoxin-induced seizure in the rat.
Topics: Animals; Anticonvulsants; Diazepam; Female; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Seizures; Thiopental | 1993 |
Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Ethosuximide; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Seizures | 1993 |
Behavioral effects of acute and long-term administration of catnip (Nepeta cataria) in mice.
Topics: Animals; Behavior, Animal; Catalepsy; Male; Mice; Motor Activity; Pentobarbital; Picrotoxin; Plant Extracts; Plant Leaves; Plants, Medicinal; Seizures; Sleep; Stereotyped Behavior; Strychnine | 1995 |
Frontal cortex leads other brain structures in generalised spike-and-wave spindles and seizure spikes induced by picrotoxin.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy, Generalized; Frontal Lobe; GABA Antagonists; Male; Mathematics; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Thalamus; Time Factors | 1996 |
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbital; Phenytoin; Picrotoxin; Rats; Rats, Wistar; Seizures | 1996 |
Evidence disputing the link between seizure activity and high extracellular glutamate.
Topics: Animals; Dicarboxylic Acids; Electroencephalography; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; Membrane Potentials; Microdialysis; Neurotransmitter Uptake Inhibitors; Picrotoxin; Pyrrolidines; Rats; Rats, Sprague-Dawley; Seizures | 1996 |
Pentobarbitone induces Fos in astrocytes: increased expression following picrotoxin and seizures.
Topics: Animals; Antibody Specificity; Astrocytes; Chloride Channels; Convulsants; GABA-A Receptor Antagonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Oncogene Proteins v-fos; Pentobarbital; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures | 1996 |
Factors determining proconvulsant and anticonvulsant effects of inhibitors of nitric oxide synthase in rodents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Indazoles; Kainic Acid; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Picrotoxin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Species Specificity | 1996 |
Treatment with an antisense oligodeoxynucleotide to the GABAA receptor gamma 2 subunit increases convulsive threshold for beta-CCM, a benzodiazepine "inverse agonist', in rats.
Topics: Analysis of Variance; Animals; Body Weight; Carbolines; Convulsants; Injections, Intraventricular; Male; Oligonucleotides, Antisense; Picrotoxin; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Seizures; Strychnine | 1996 |
Distinct effects of N omega-nitro-L-arginine on seizures induced by several drugs in mice.
Topics: Animals; Arginine; Bicuculline; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures; Time Factors | 1996 |
Gonadal hormones and picrotoxin-induced convulsions in male and female rats.
Topics: Analysis of Variance; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Cerebral Cortex; Estradiol; Female; Ligands; Male; Orchiectomy; Ovariectomy; Picrotoxin; Rats; Rats, Wistar; Seizures; Sex Characteristics; Testosterone | 1996 |
Effects of NMDA antagonists on seizure thresholds induced by intrahippocampal microdialysis of picrotoxin in freely moving rats.
Topics: Animals; Electroencephalography; Hippocampus; Male; Microdialysis; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Sensory Thresholds | 1996 |
Picrotoxin produces a "central" pain-like syndrome when microinjected into the somato-motor cortex of the rat.
Topics: Animals; Behavior, Animal; Male; Microinjections; Pain; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Somatosensory Cortex | 1996 |
Fos induction in subtypes of cerebrocortical neurons following single picrotoxin-induced seizures.
Topics: Animals; Calcium-Binding Proteins; Cerebral Cortex; Dendrites; Immunohistochemistry; Male; Nerve Tissue Proteins; Neurons; Picrotoxin; Proto-Oncogene Proteins c-fos; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures | 1996 |
Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice.
Topics: Animals; Bicuculline; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Protein-Tyrosine Kinases; Seizures | 1996 |
Real-time spike detection in EEG signals using the wavelet transform and a dedicated digital signal processor card.
Topics: Algorithms; Animals; Computer Systems; Electroencephalography; GABA Antagonists; Microcomputers; Models, Theoretical; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Signal Processing, Computer-Assisted; Software | 1996 |
Behavioural responsiveness to picrotoxin and desipramine in adult rats prenatally exposed to different benzodiazepine receptor agonists.
Topics: Adrenergic Uptake Inhibitors; Alprazolam; Animals; Behavior, Animal; Desipramine; Diazepam; Female; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Rats; Rats, Wistar; Seizures; Zolpidem | 1995 |
A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor.
Topics: Allosteric Regulation; Animals; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; Dose-Response Relationship, Drug; GABA Modulators; Hypnotics and Sedatives; Male; Muscle Relaxation; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Sesterterpenes; Triazoles | 1996 |
[The effect of picrotoxin-induced seizure activity on the cAMP-dependent phosphorylation of synapsin-I in rats].
Topics: Animals; Cerebral Cortex; Convulsants; Cyclic AMP; Hippocampus; Male; Phosphorus Radioisotopes; Phosphorylation; Picrotoxin; Rats; Rats, Wistar; Seizures; Synapsins; Synaptosomes | 1996 |
[The effect of aminooxyacetic acid on the antidote activity of diazepam after exposure to GABA-lytics].
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Drug Interactions; GABA Agents; Male; Mice; Picrotoxin; Seizures | 1994 |
Chinese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Drugs, Chinese Herbal; Electroshock; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoin; Picrotoxin; Potassium; Rats; Seizures; Sesquiterpenes, Eudesmane; Terpenes | 1997 |
Comparative in vivo and in vitro studies with the potent GABAB receptor antagonist, CGP 56999A.
Topics: Animals; Baclofen; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; GABA-B Receptor Antagonists; In Vitro Techniques; Injections, Intraperitoneal; Male; Mice; Neurons; Pentylenetetrazole; Phosphinic Acids; Picrotoxin; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Seizures; Stereotyped Behavior | 1997 |
[Anti-convulsion effects of choto-san and chotoko (Uncariae Uncis cam Ramlus) in mice, and identification of the active principles].
Topics: Alkaloids; Animals; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutamic Acid; Indole Alkaloids; Indoles; Male; Mice; Mice, Inbred Strains; Picrotoxin; Seizures; Strychnine | 1997 |
Synthesis and anticonvulsant activity of a new class of 2-[(arylalky)amino]alkanamide derivatives.
Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Bicuculline; Drug Design; Electroshock; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Structure; Motor Activity; Picrotoxin; Postural Balance; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship; Strychnine | 1998 |
Laminar distribution of Fos/calcium-binding protein and Fos/neurofilament protein-labeled neurons in rat motor and sensory cortex after picrotoxin-induced seizures.
Topics: Animals; Calbindin 2; Calbindins; Calcium-Binding Proteins; Cerebral Cortex; Male; Motor Cortex; Nerve Tissue Proteins; Neurofilament Proteins; Neurons; Parvalbumins; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Seizures; Somatosensory Cortex | 1998 |
Further studies on anti- and proconvulsant effects of inhibitors of nitric oxide synthase in rodents.
Topics: Animals; Anticonvulsants; Convulsants; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures | 1998 |
Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments.
Topics: Amino Acids; Animals; Aspartic Acid; Electroencephalography; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Male; Microdialysis; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Taurine | 1998 |
[Mechanisms of development of elevated seizure readiness during norbornene intoxication].
Topics: Animals; Bicuculline; Chloride Channels; Convulsants; Dopamine Antagonists; GABA Agonists; GABA Antagonists; Kindling, Neurologic; Lethal Dose 50; Male; Mice; Muscarinic Agonists; Norbornanes; Picrotoxin; Receptors, GABA-A; Seizures | 1998 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Strychnine; Time Factors; Weaning | 1999 |
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Clonidine; Dextromethorphan; Drug Interactions; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ketamine; Mice; Muscimol; N-Methylaspartate; Picrotoxin; Receptors, GABA; Receptors, Glutamate; Seizures; Theophylline | 1999 |
Picrotoxin-, kainic acid- and seizure-induced Fos in brainstem, with special reference to catecholamine cell groups.
Topics: Animals; Brain Stem; Gene Expression Regulation; Genes, fos; Kainic Acid; Male; Neurons; Neurotoxins; Organ Specificity; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1999 |
Calpain inhibitor I retards seizure offset in the hippocampus of freely moving rats.
Topics: Animals; Cysteine Proteinase Inhibitors; Electroencephalography; Glycoproteins; Male; Perfusion; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Time Factors; Videotape Recording | 1999 |
Involvement of nitric oxide and nitric oxide synthase activity in anticonvulsive action.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Synergism; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Picrotoxin; Rats; Rats, Wistar; Seizures | 1999 |
Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat.
Topics: Analysis of Variance; Animals; Brain Ischemia; Convulsants; Lidocaine; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Prosencephalon; Rats; Rats, Sprague-Dawley; Seizures | 1999 |
Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy.
Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Carbolines; Convulsants; Electroencephalography; Epilepsy, Absence; Frontal Lobe; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoniazid; Kainic Acid; Limbic System; Male; Parietal Lobe; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Strychnine | 2000 |
Roles of group II metabotropic glutamate receptors in modulation of seizure activity.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Brain; Bridged Bicyclo Compounds; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Electrophysiology; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures | 2000 |
Design and synthesis of anticonvulsive agents as gamma-vinyl GABA-based potential dual acting prodrugs and their biological activities.
Topics: Animals; Anticonvulsants; Bicuculline; Drug Design; Mice; Pentylenetetrazole; Picrotoxin; Prodrugs; Seizures; Vigabatrin | 2000 |
Effects of L-arginine on picrotoxin-induced increase in brain ammonia concentrations and convulsions in rats.
Topics: Ammonia; Animals; Anticonvulsants; Arginine; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Tissue Distribution | 1999 |
Guanosine and GMP prevent seizures induced by quinolinic acid in mice.
Topics: Animals; Anticonvulsants; Central Nervous System; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine; Guanosine Monophosphate; Male; Mice; Neurons; Picrotoxin; Quinolinic Acid; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Seizures; Time Factors | 2000 |
Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Picrotoxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures | 2000 |
Chemical kindling and seizure susceptibility in morphine dependent rats.
Topics: Animals; Caffeine; Convulsants; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Kindling, Neurologic; Male; Morphine; Morphine Dependence; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA; Receptors, Purinergic P1; Seizures | 2000 |
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids | 2000 |
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
Topics: Animals; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; Microdialysis; Motor Activity; Neural Inhibition; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2001 |
Beta-1 adrenoceptor antagonists potentiate the anticonvulsive effect of swim stress in mice.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Betaxolol; Convulsants; Male; Mice; Mice, Inbred CBA; Picrotoxin; Propanolamines; Propranolol; Receptors, Adrenergic, beta-1; Seizures; Stress, Physiological; Swimming | 2000 |
Swim stress alters the behavioural response of mice to GABA-related and some GABA-unrelated convulsants.
Topics: Animals; Behavior, Animal; Convulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Mice, Inbred CBA; Picrotoxin; Seizures; Stress, Physiological; Swimming; Temperature; Water | 2001 |
Activation of neostriatal dopaminergic system in rats prevents toxic effects of picrotoxin administered into globus pallidus.
Topics: Amphetamine; Animals; Dopamine; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Male; Motor Activity; Neostriatum; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Seizures | 2000 |
Effect of picrotoxin-induced seizures on lipid composition of cortical tissue homogenate and its nuclear fraction in rats.
Topics: Animals; Cell Nucleus; Cerebral Cortex; Convulsants; Lipid Metabolism; Male; Picrotoxin; Rats; Rats, Wistar; Seizures | 2000 |
Effect of systemically administered nitric oxide donor, sodium nitroprusside on picrotoxin-induced convulsions in rats.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Picrotoxin; Rats; Rats, Wistar; Seizures; Vasodilator Agents | 2001 |
Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Drug Combinations; Drug Tolerance; Male; Mice; Midazolam; Muscle, Skeletal; Picrotoxin; Pregnanolone; Receptors, GABA-A; Seizures | 2001 |
Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam.
Topics: Ammonia; Animals; Arginine; Brain; Diazepam; Drug Interactions; Epilepsy; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hyperammonemia; Male; Neural Inhibition; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Synaptic Transmission | 2001 |
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Injections, Intraventricular; Male; Mice; Pentobarbital; Picrotoxin; Pyrazines; Seizures; Sleep; Time Factors; Valproic Acid | 2001 |
The involvement of alpha2-adrenoceptors in the anticonvulsive effect of swim stress in mice.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Antagonists; Animals; Convulsants; Dihydropyridines; GABA-A Receptor Antagonists; Idazoxan; Infusions, Intravenous; Injections, Intraperitoneal; Male; Mice; Mice, Inbred CBA; Picrotoxin; Receptors, Adrenergic, alpha-2; Seizures; Stress, Physiological; Swimming | 2001 |
Delayed impairment of response extinction after single seizures induced by picrotoxin.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Convulsants; Extinction, Psychological; Habituation, Psychophysiologic; Male; Picrotoxin; Rats; Rats, Wistar; Seizures | 2002 |
Picrotoxin-induced generalised convulsive seizure in rat: changes in regional distribution and frequency of the power of electroencephalogram rhythms.
Topics: Animals; Brain; Convulsants; Electroencephalography; Frontal Lobe; Hindlimb; Intralaminar Thalamic Nuclei; Male; Picrotoxin; Pons; Rats; Rats, Sprague-Dawley; Seizures; Signal Processing, Computer-Assisted | 2002 |
Anticonvulsant activity of aqueous extract of Leonotis leonurus.
Topics: Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Lamiaceae; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures | 2002 |
Anticonvulsive activity of Butea monosperma flowers in laboratory animals.
Topics: Animals; Anticonvulsants; Behavior, Animal; Butea; Convulsants; Dyskinesia, Drug-Induced; Electroshock; Flowers; Lithium; Male; Pentylenetetrazole; Picrotoxin; Pilocarpine; Postural Balance; Rats; Rats, Sprague-Dawley; Seizures; Strychnine | 2002 |
Antagonism of picrotoxin-induced changes in dopamine and serotonin metabolism by allopregnanolone and midazolam.
Topics: Amino Acids; Animals; Convulsants; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; Injections, Intraventricular; Male; Mice; Microinjections; Midazolam; Picrotoxin; Pregnanolone; Seizures; Serotonin | 2002 |
The influence of neuromediators injected into nucleus caudatus on bioelectrical seizure activity of amygdala.
Topics: Amygdala; Animals; Caudate Nucleus; Dopamine; Electrodes, Implanted; Glutamates; Injections; Male; Methacholine Compounds; Neostigmine; Neurotransmitter Agents; Picrotoxin; Rabbits; Seizures; Serotonin; Stimulation, Chemical | 1976 |
Putative neurotransmitters in CNS and chemoconvulsions.
Topics: Animals; Bemegride; Catecholamines; Central Nervous System; Female; Male; Mice; Neurotransmitter Agents; Pentylenetetrazole; Picrotoxin; Procaine; Seizures; Strychnine | 1977 |
Interaction between the activity of an epileptic focus and discrete skilled movements in rats.
Topics: Action Potentials; Animals; Forelimb; Functional Laterality; Male; Motor Cortex; Movement; Neural Inhibition; Neural Pathways; Picrotoxin; Rats; Seizures; Time Factors | 1975 |
Functions of primary afferents and responses of extracellular K+ during spinal epileptiform seizures.
Topics: Action Potentials; Animals; Cats; Extracellular Space; Membrane Potentials; Neural Inhibition; Neurons; Neurons, Afferent; Penicillin G; Pentobarbital; Picrotoxin; Potassium; Seizures; Spinal Cord; Spinal Nerve Roots | 1976 |
Differential effects of cortical speading depression on epileptic foci induced by various convulsants.
Topics: Animals; Cerebral Cortex; Convulsants; Cortical Spreading Depression; Electroencephalography; Male; Penicillin G; Pentylenetetrazole; Picrotoxin; Potassium; Rats; Seizures; Spironolactone; Strychnine | 1977 |
Effect of p-chlorophenylalanine on the central nervous excitability threshold and on the activity of some central depressants.
Topics: Animals; Central Nervous System; Depression, Chemical; Fenclonine; Hypnotics and Sedatives; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenylacetates; Picrotoxin; Seizures; Strychnine; Time Factors; Toluene; Urea | 1975 |
Attempts to produce spike-and-wave complexes in the electrocorticogram of the rat.
Topics: Animals; Cerebral Cortex; Cobalt; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Estrogens, Conjugated (USP); Fluoroacetates; Male; Methionine Sulfoximine; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1975 |
Effects of certain drugs connected with the system of 3',5'-cAMP on the picrotoxin convulsive-seizure threshold and on the action of GABA.
Topics: Aminobutyrates; Animals; Brain; Bucladesine; Cyclic AMP; Drug Interactions; gamma-Aminobutyric Acid; Isoproterenol; Male; Mice; Picrotoxin; Seizures | 1976 |
Effect of isopropylnoradrenaline, adenosine, cyclic 3',5'-adenosinemonosphosphate and dibutyryl cyclic adenosinemonophosphate on the picrotoxin convulsive-seizure threshold. Interaction with gamma-aminobutyric acid.
Topics: Adenosine; Aminobutyrates; Animals; Bucladesine; Cyclic AMP; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; Norepinephrine; Picrotoxin; Seizures | 1976 |
Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Synaptic Transmission | 1979 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hydrazines; Male; Mice; Pentylenetetrazole; Phenelzine; Picrotoxin; Pyridoxine; Reaction Time; Seizures; Thiones; Valproic Acid | 1977 |
Comparative effects of centrophenoxine on the picrotoxin convulsive-seizure threshold in non-irradiated and irradiated mice.
Topics: Animals; Glycolates; Injections, Intraventricular; Male; Meclofenoxate; Mice; Picrotoxin; Radiation Injuries, Experimental; Seizures; Time Factors | 1978 |
Facilitation of bicuculline- and picrotoxin-induced seizures by sodium valproate in rats.
Topics: Animals; Bicuculline; Drug Synergism; Male; Picrotoxin; Rats; Seizures; Valproic Acid | 1979 |
Involvement of central GABA-ergic systems in convulsions and aggressive behavior.
Topics: 4-Aminobutyrate Transaminase; Aggression; Allylglycine; Animals; Bicuculline; Brain; Fatty Acids; gamma-Aminobutyric Acid; Humans; Kinetics; Mice; Muscimol; Picrotoxin; Rats; Seizures; Structure-Activity Relationship; Valproic Acid | 1979 |
Effects of intracerebroventricular administration of prostaglandins E1 and E2 on chemically induced convulsions in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intraventricular; Isoniazid; Male; Mice; Pentylenetetrazole; Picrotoxin; Prostaglandins E; Seizures; Strychnine | 1979 |
Effect of tryptophol on pentylenetetrazol and picrotoxin induced convulsion in mice.
Topics: Animals; Anticonvulsants; Brain; Indoles; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures | 1979 |
Hypersynchronisation and sedation produced by GABA-transaminase inhibitors and picrotoxin: does GABA participate in sleep control?
Topics: 4-Aminobutyrate Transaminase; Animals; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Seizures; Sleep Stages; Transaminases | 1979 |
Role of dopaminergic and GABA-ergic interactions in seizure susceptibility.
Topics: Aminooxyacetic Acid; Animals; Apomorphine; Dopamine; Electroshock; Female; gamma-Aminobutyric Acid; Haloperidol; Male; Mice; Picrotoxin; Piribedil; Reserpine; Seizures | 1979 |
The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.
Topics: Animals; Brain; Diazepam; In Vitro Techniques; Male; Mice; Oxazoles; Oxygen; Pentylenetetrazole; Picrotoxin; Prostaglandins; Seizures; Thromboxanes; Time Factors; Trimethadione | 1979 |
Comparative study of the antagonism of bemegride and picrotoxin on behavioural depressant effects of diazepam in rats and mice.
Topics: Amnesia; Animals; Behavior, Animal; Bemegride; Diazepam; Humans; Male; Mice; Motor Activity; Motor Skills; Picrotoxin; Rats; Seizures; Strychnine | 1978 |
Comparison of effects of bicuculline, strychnine, and picrotoxin with those of pentylenetetrazol on photically evoked afterdischarges.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Electroencephalography; Isoquinolines; Light; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine; Visual Cortex | 1977 |
Effect of four convulsants on the time course of presynaptic inhibition and the relation to seizure activity.
Topics: Animals; Bemegride; Bicuculline; Cerebral Cortex; Convulsants; Instinct; Male; Medulla Oblongata; Neural Inhibition; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1977 |
[Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam].
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; gamma-Aminobutyric Acid; Imidazoles; Male; Mice; Papaverine; Picrotoxin; Seizures; Theophylline; Time Factors | 1978 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; Female; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Strychnine; Trimethadione; Valerates; Valproic Acid | 1976 |
Antagonism of GABA-mediated inhibition in the central nervous system by caprolactam derivatives.
Topics: Aminobutyrates; Animals; Azepines; Brain; Caprolactam; Evoked Potentials; GABA Antagonists; Neural Inhibition; Picrotoxin; Rabbits; Seizures; Structure-Activity Relationship; Substantia Nigra | 1976 |
Tracing the neural circuits of pecking and licking with intracerebral injection of convulsants.
Topics: Animals; Brain; Brain Mapping; Columbidae; Feeding Behavior; Models, Neurological; Neural Pathways; Picrotoxin; Rats; Seizures | 1976 |
Retention disruption following post-trial picrotoxin injection into the substantia nigra.
Topics: Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Memory; Picrotoxin; Rats; Reaction Time; Retention, Psychology; Seizures; Strychnine; Substantia Nigra | 1976 |
Electroencephalographic correlates of the audiogenic seizure response of inbred mice.
Topics: Acoustic Stimulation; Animals; Brain Stem; Cerebral Cortex; Female; Genetics, Behavioral; Male; Mice; Mice, Inbred Strains; Phenotype; Picrotoxin; Seizures | 1976 |
Changes in regional brain acetylcholine levels during drug-induced convulsions.
Topics: Acetylcholine; Animals; Bicuculline; Brain Chemistry; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Strychnine | 1976 |
Effects of apomorphine, pimoside, theophylline, meta-tolylcarbamide and diazepam on the picrotoxin convulsive-seizure threshold.
Topics: Animals; Apomorphine; Brain; Diazepam; Male; Mice; Phenylurea Compounds; Picrotoxin; Pimozide; Seizures; Theophylline | 1976 |
Are the central dopaminergic synapses related to the convulsive-seizure threshold?--Effects of central dopaminergic drugs on the picrotoxin convulsive-seizure threshold. Interaction with diazepam, meta-tolylcarbamide and theophylline.
Topics: Animals; Apomorphine; Diazepam; Drug Interactions; Male; Mice; Phenylurea Compounds; Picrotoxin; Pimozide; Receptors, Dopamine; Seizures; Theophylline | 1976 |
Analysis of preseizure electrocorticographic changes in rats during hyperbaric oxygenation.
Topics: Animals; Diagnosis, Computer-Assisted; Electroencephalography; Hyperbaric Oxygenation; Male; Oxygen; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1975 |
Blockage of cortical spreading depression by picrotoxin foci of paroxysmal activity.
Topics: Animals; Brain; Cerebral Cortex; Cortical Spreading Depression; Electroencephalography; Pentylenetetrazole; Picrotoxin; Potassium; Potassium Chloride; Rats; Seizures; Tubocurarine | 1975 |
Enhancement of picrotoxin convulsions in chicks and mice by the prior intraperitoneal injection of hypertonic GABA or mannitol.
Topics: Aminobutyrates; Animals; Animals, Newborn; Chickens; Drug Synergism; gamma-Aminobutyric Acid; Hypertonic Solutions; Injections, Intraperitoneal; Mannitol; Mice; Mice, Inbred Strains; Picrotoxin; Seizures; Time Factors | 1975 |
Rotational behavior induced in rats by intranigral picrotoxin.
Topics: Animals; Behavior, Animal; Brain Mapping; Dose-Response Relationship, Drug; Functional Laterality; GABA Antagonists; Injections; Male; Neural Inhibition; Neural Pathways; Picrotoxin; Rats; Rotation; Seizures; Substantia Nigra; Time Factors | 1975 |
The anticonvulsant action of GABA-elevating agents: a re-evaluation.
Topics: Allyl Compounds; Aminobutyrates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hydrazines; Hydroxylamines; Hyperbaric Oxygenation; Isoniazid; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Stimulation, Chemical; Time Factors | 1975 |
Locomotor activity and seizures induced by picrotoxin in the fastigeal nucleus of the rat.
Topics: Animals; Cerebellar Nuclei; gamma-Aminobutyric Acid; Locomotion; Male; Neural Inhibition; Ouabain; Picrotoxin; Rats; Seizures | 1975 |
Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+)MK-801 and voltage-dependent calcium channel blockers.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Convulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hexachlorocyclohexane; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nifedipine; Pentylenetetrazole; Picrotoxin; Seizures; Sesterterpenes; Species Specificity | 1992 |
Effects of clonazepam on picrotoxin-induced convulsions.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Epilepsy; Injections, Intraperitoneal; Picrotoxin; Rats; Rats, Wistar; Seizures | 1992 |
[Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum].
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Diazepam; GABA Antagonists; Male; Muscimol; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Tritium | 1992 |
Branched-chain amino acids increase the seizure threshold to picrotoxin in rats.
Topics: Amino Acids, Branched-Chain; Animals; Anticonvulsants; GABA-A Receptor Antagonists; Male; Picrotoxin; Rats; Rats, Wistar; Seizures | 1992 |
[The effect of activation of the superior colliculus on the convulsive activity during picrotoxin-induced kindling].
Topics: Animals; Bicuculline; Electroencephalography; Kindling, Neurologic; Male; Microinjections; Penicillin G; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Superior Colliculi | 1992 |
Effects of somatostatin and anti-somatostatin serum on picrotoxin-kindled seizures.
Topics: Animals; Injections, Intraventricular; Kindling, Neurologic; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Somatostatin | 1992 |
[The threshold lowering effects of chronic treatment with haloperidol on beta-carboline derivative-induced tonic convulsion].
Topics: Animals; Bicuculline; Carbolines; Drug Administration Schedule; Drug Interactions; Haloperidol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Seizures | 1992 |
[Effects of neurotropin on seizure activity in picrotoxin kindling].
Topics: Animals; Anticonvulsants; Ceruletide; Cycloheximide; Electroencephalography; Injections, Intraperitoneal; Injections, Intraventricular; Kindling, Neurologic; Male; Picrotoxin; Polysaccharides; Rats; Rats, Wistar; Seizures | 1992 |
Neuropharmacology of amide derivatives of P-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Brain; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Muscle Relaxation; Nervous System; Picrotoxin; Seizures | 1992 |
Changes at cholecystokinin receptors induced by long-term treatment with diazepam and haloperidol.
Topics: Aggression; Animals; Behavior, Animal; Ceruletide; Dextroamphetamine; Diazepam; Electroshock; Haloperidol; Male; Mice; Motor Activity; Picrotoxin; Receptors, Cholecystokinin; Seizures | 1992 |
Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures.
Topics: Animals; Binding Sites; Cerebral Cortex; Flunitrazepam; Hippocampus; Hyperthyroidism; Isoniazid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Triiodothyronine | 1992 |
Altered response to GABAergic agents following electro and chemo convulsions in mice.
Topics: Animals; Bicuculline; Electroshock; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1991 |
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Female; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A; Seizures; Strychnine; Synaptosomes | 1991 |
[The role of the opiate mechanisms of the hippocampus and substantia nigra in the behavioral and convulsive disorders in picrotoxin-induced kindling].
Topics: Analgesics; Animals; Behavior, Animal; Drug Interactions; Dynorphins; Enkephalin, Methionine; Hippocampus; Kindling, Neurologic; Male; Narcotics; Peptide Fragments; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Seizures; Substantia Nigra | 1991 |
Paradoxical role of GABA in a chronic model of petit mal (absence)-like epilepsy in the rat.
Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Epilepsy, Absence; GABA Antagonists; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Seizures; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1990 |
Pharmacological evidence indicating a role of GABAergic systems in termination of limbic seizures.
Topics: Animals; Baclofen; Bicuculline; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Ion Channels; Limbic System; Male; Membrane Proteins; Muscimol; Neural Inhibition; Picrotoxin; Rats; Seizures | 1990 |
Toxicokinetics of Ro 5-4864, lindane and picrotoxin compared.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Body Temperature; Body Weight; Convulsants; Dose-Response Relationship, Drug; Eating; Female; Hexachlorocyclohexane; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
Changes in limbic evoked potentials produced by the atypical benzodiazepine Ro 5-4864.
Topics: Animals; Benzodiazepinones; Convulsants; Evoked Potentials; Female; Hexachlorocyclohexane; Hippocampus; Limbic System; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
Evidence that genetic differences in habituation and GABAergic mechanisms may be related to sensitivity to ethanol and development of ethanol tolerance in mice.
Topics: Animals; Avoidance Learning; Bicuculline; Body Temperature; Brain; Drug Tolerance; Environment; Ethanol; gamma-Aminobutyric Acid; Habituation, Psychophysiologic; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Motor Activity; Picrotoxin; Postural Balance; Seizures; Sleep; Species Specificity | 1991 |
Influence of cerebro-spinal fluid of picrotoxin kindled rats on seizure susceptibility and locomotor activity of recipients.
Topics: Animals; Cerebrospinal Fluid; Kindling, Neurologic; Locomotion; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
Regional and time dependent variations of low Mg2+ induced epileptiform activity in rat temporal cortex slices.
Topics: Animals; Baclofen; Brain Mapping; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Magnesium; Picrotoxin; Pyramidal Tracts; Rats; Seizures; Temporal Lobe | 1991 |
Changes in rat brain extracellular glutamate concentration during seizures induced by systemic picrotoxin or focal bicuculline injection: an in vivo dialysis study with on-line enzymatic detection.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicuculline; Brain Chemistry; Cerebral Cortex; Dialysis; Electroencephalography; Electroshock; Extracellular Space; Glutamates; Hippocampus; Injections; Kainic Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
[Drug-induced seizures in taurine-deficient mice].
Topics: Amino Acids; Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine; Taurine | 1991 |
Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors.
Topics: Animals; Azides; Benzodiazepines; Carbolines; GABA Antagonists; Isoniazid; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1991 |
Effect of phenobarbital on motor seizures elicited by picrotoxin and bicuculline in rats.
Topics: Animals; Bicuculline; Male; Pentylenetetrazole; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
A peptidase-resistant cyclic octapeptide analogue of somatostatin (SMS 201-995) modulates seizures induced by quinolinic and kainic acids differently in the rat hippocampus.
Topics: Animals; Atropine; Convulsants; Electroencephalography; Hippocampus; Kainic Acid; Male; Octreotide; Picrotoxin; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures | 1991 |
Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.
Topics: 4-Butyrolactone; Alkylation; Animals; Anticonvulsants; Brain; Convulsants; Female; Ligands; Mice; Mice, Inbred Strains; Molecular Structure; Neurotoxins; Picrotoxin; Receptors, GABA-A; Seizures; Structure-Activity Relationship | 1991 |
Castration alters susceptibility of male rats to specific seizures.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Estrogens; Male; Orchiectomy; Picrotoxin; Rats; Reaction Time; Seizures; Testosterone | 1991 |
The proconvulsive activity of quinolone antibiotics in an animal model.
Topics: Animals; Anti-Infective Agents; Convulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Nalidixic Acid; Oxolinic Acid; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1991 |
Croton zehntneri: possible central nervous system effects in rodents.
Topics: Animals; Anticonvulsants; Brazil; Male; Medicine, Traditional; Mice; Phenobarbital; Picrotoxin; Plant Extracts; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1991 |
Ro 5-4864, like picrotoxin, enhances EPSP-spike coupling in the freely behaving rat.
Topics: Animals; Benzodiazepinones; Convulsants; Electric Stimulation; Evoked Potentials; Female; Hippocampus; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
Seizure promotion and protection by D-1 and D-2 dopaminergic drugs in the mouse.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Synergism; Ergolines; Female; Indoles; Male; Mice; Phenanthridines; Picrotoxin; Pilocarpine; Quinpirole; Seizures; Strychnine | 1990 |
Low-level hyperbaric heliox does not affect drug-induced seizure latency in mice.
Topics: Allylglycine; Animals; Atmospheric Pressure; Convulsants; Helium; Hyperbaric Oxygenation; Isoniazid; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Myoclonus; Picrotoxin; Seizures; Time Factors | 1991 |
Threshold to elicit seizures by picrotoxin is lowered in pentylenetetrazol-kindled mice.
Topics: Animals; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizures | 1990 |
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1990 |
Involvement of the nigral output pathways in the inhibitory control of the substantia nigra over generalized non-convulsive seizures in the rat.
Topics: Animals; Brain; Dopamine; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Hydroxydopamines; Male; Muscimol; Norepinephrine; Oxidopamine; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Serotonin; Substantia Nigra | 1990 |
NMDA antagonist properties of gamma-L-glutamyl-L-aspartate demonstrated on chemically induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dipeptides; Dose-Response Relationship, Drug; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Seizures | 1990 |
Neuropharmacological actions of the superactive agonist analog D-TRP-6-LH-RH after peripheral injection into mice.
Topics: Analgesia; Animals; Apomorphine; Behavior, Animal; Catalepsy; Central Nervous System; Exploratory Behavior; Gonadotropin-Releasing Hormone; Male; Mice; Pain Measurement; Picrotoxin; Seizures; Stereotyped Behavior; Triptorelin Pamoate | 1990 |
Dual species dependent effect of dihydroergosine on the convulsions induced by GABA antagonists.
Topics: Animals; Antidepressive Agents; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Ergotamines; Female; Male; Mice; Mice, Inbred CBA; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Species Specificity | 1990 |
Synchronous discharges in the rat entorhinal cortex in vitro: site of initiation and the role of excitatory amino acid receptors.
Topics: Action Potentials; Animals; Bicuculline; Cats; Cerebral Cortex; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1990 |
Are GABAB receptors involved in the pharmacological effects of ethanol?
Topics: Animals; Baclofen; Cells, Cultured; Chlorine; Diazepam; Ethanol; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Picrotoxin; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Spinal Cord | 1990 |
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neurologic; Male; Picrotoxin; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Purinergic; Rolipram; Seizures; Theophylline; Xanthines | 1990 |
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
Topics: Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Lethal Dose 50; Male; Methaqualone; Mice; Molecular Structure; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship; Strychnine | 1990 |
The effect of nimodipine on picrotoxin-induced seizures.
Topics: Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Male; Nimodipine; Picrotoxin; Rats; Seizures | 1990 |
Gender difference in susceptibility to picrotoxin-induced seizures is seizure- and stimulation-dependent.
Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Picrotoxin; Rats; Reaction Time; Seizures; Sex Characteristics | 1990 |
The GABAergic nigro-collicular pathway is not involved in the inhibitory control of audiogenic seizures in the rat.
Topics: Acoustic Stimulation; Animals; Male; Microinjections; Muscimol; Neural Pathways; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Superior Colliculi | 1990 |
Effect of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Decanoic Acids; Fatty Acids; Lauric Acids; Male; Mice; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Pentylenetetrazole; Picrotoxin; Seizures; Stearic Acids | 1990 |
Suppression of spontaneous generalized non-convulsive seizures in the rat by microinjection of GABA antagonists into the superior colliculus.
Topics: Animals; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Male; Microinjections; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Superior Colliculi | 1990 |
Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Ethanol; Kainic Acid; Male; N-Methylaspartate; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1990 |
Differential effects of gamma-hexachlorocyclohexane (lindane) on pharmacologically-induced seizures.
Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; Hexachlorocyclohexane; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1987 |
Opposite effects of different hexachlorocyclohexane (lindane) isomers on cerebellar cyclic GMP: relation of cyclic GMP accumulation to seizure activity.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Cyclic GMP; Hexachlorocyclohexane; Isomerism; Male; Mice; Picrotoxin; Seizures; Strychnine | 1987 |
CNS biochemical and pharmacological effects of the isomers of hexachlorocyclohexane (lindane) in the mouse.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Drug Synergism; Hexachlorocyclohexane; Ion Channels; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures | 1988 |
Convulsant properties of GABA antagonists and anticonvulsant properties of ethanol in selectively bred long- and short-sleep mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Ethanol; GABA Antagonists; Mice; Picrotoxin; Seizures | 1989 |
Ultrastructural changes in granule cell somata and mossy fibers of the rat hippocampus during picrotoxin-induced convulsions.
Topics: Animals; Hippocampus; Inclusion Bodies; Male; Microscopy, Electron; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1989 |
Effects of picrotoxin treatment on GABAA receptor supramolecular complexes in rat brain.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Flunitrazepam; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tissue Distribution | 1989 |
Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Dose-Response Relationship, Drug; Frontal Lobe; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Muscimol; Pentobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Species Specificity; Synaptosomes | 1989 |
Interaction between GABAergic anticonvulsants and the NMDA receptor antagonist MK 801 against MES- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Electroshock; Ethanol; Male; Motor Activity; Pentobarbital; Phenobarbital; Phenytoin; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Stereotyped Behavior | 1989 |
Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Blotting, Northern; Convulsants; DNA-Binding Proteins; Electroshock; Gene Expression Regulation; Immunoblotting; Kainic Acid; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; Nucleic Acid Hybridization; Pentylenetetrazole; Picrotoxin; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Seizures; Transcription Factors | 1989 |
A slow NMDA-mediated synaptic potential underlies seizures originating from midbrain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; In Vitro Techniques; Inferior Colliculi; N-Methylaspartate; Picrotoxin; Rats; Seizures; Valine | 1989 |
Changes in the activity of glutamate related enzymes in cerebral cortex, during insulin-induced seizures.
Topics: Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Blood Glucose; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Insulin; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1989 |
Steroid hormone effects on picrotoxin-induced seizures in female and male rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Implants; Estradiol; Female; Male; Ovariectomy; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Sex Factors; Testosterone | 1989 |
RO15-4513 but not FG-7142 reverses anticonvulsant effects of ethanol against bicuculline- and picrotoxin-induced convulsions in rats.
Topics: Affinity Labels; Animals; Appetite Depressants; Azides; Benzodiazepines; Bicuculline; Carbolines; Ethanol; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1989 |
The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxinin.
Topics: Animals; Anxiety; Bicuculline; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; GABA Antagonists; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Sesterterpenes; Substance Withdrawal Syndrome | 1989 |
Effects of the diterpene sclareol glycol on convulsive seizures.
Topics: Animals; Bicuculline; Colforsin; Convulsants; Diterpenes; Drug Synergism; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1989 |
Behavioral aspects of GABAergic-dopaminergic interactions in the central nervous system.
Topics: 3-Mercaptopropionic Acid; Animals; Dopamine; gamma-Aminobutyric Acid; Haloperidol; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Stereotyped Behavior; Strychnine; Time Factors | 1989 |
[Development of motor and emotional disorders in rats during daily administration of subliminal doses of picrotoxin].
Topics: Animals; Behavior, Animal; Brain; Electrocardiography; Emotions; Kindling, Neurologic; Male; Movement Disorders; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Syndrome; Time Factors | 1989 |
Behavioral and functional studies indicate a role for GABAAergic transmission in the actions of ethanol.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Ethanol; Flunitrazepam; Male; Mice; Mice, Inbred C57BL; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Spinal Cord | 1987 |
Changes in benzodiazepine/GABA receptor complex function in benzodiazepine-tolerant mice.
Topics: Animals; Anticonvulsants; Bicuculline; Body Temperature; Drug Tolerance; Flurazepam; gamma-Aminobutyric Acid; Infusions, Intravenous; Male; Mice; Motor Activity; Pentobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Time Factors | 1988 |
Picrotoxin, a gamma-aminobutyric acid-receptor antagonist, retards craniofacial development in the weaning rat: I. Effect on mandibular bone growth.
Topics: Alkaline Phosphatase; Animals; Body Weight; Calcium; Male; Mandible; Phosphorus; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Skull; Weaning | 1988 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine | 1988 |
A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Corpus Striatum; Dipeptides; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Picrotoxin; Quisqualic Acid; Rats; Seizures; Sodium | 1985 |
Absence of side-effects in the anticonvulsant action of cortically applied antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dipeptides; Morphine; N-Methylaspartate; Picrotoxin; Quinoxalines; Rats; Rats, Inbred Strains; Seizures; Strychnine; Valine | 1986 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1986 |
Effect of inferior olive lesion on seizure threshold in the rat.
Topics: Animals; Bicuculline; Cerebellum; Convulsants; Male; Motor Activity; Neural Pathways; Olivary Nucleus; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Seizures; Strychnine | 1987 |
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Competitive; Darkness; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Structure-Activity Relationship; Tetrodotoxin | 1988 |
Benzodiazepines increase tonic component of postdecapitation convulsions in mice.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Decerebrate State; Flumazenil; Male; Mice; Mice, Inbred Strains; Picrotoxin; Receptors, GABA-A; Seizures | 1988 |
Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Drug Interactions; Electroshock; Ethanol; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sleep | 1985 |
Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Injections, Spinal; Male; Mice; Nipecotic Acids; Picrotoxin; Pipecolic Acids; Proline; Receptors, GABA-A; Seizures; Strychnine | 1985 |
Convulsant component of a depressant benzodiazepine.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
[Modulating effect of cerulein on benzodiazepine receptors].
Topics: Animals; Brain; Ceruletide; Dose-Response Relationship, Drug; Drug Interactions; Flunitrazepam; Male; Mice; Picrotoxin; Proglumide; Reaction Time; Receptors, GABA-A; Seizures | 1985 |
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.
Topics: Animals; Carbachol; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Muscles; Phenobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 1986 |
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; Muscimol; Pentobarbital; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Seizures; Time Factors | 1986 |
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties.
Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Electroshock; Female; Glutamate Decarboxylase; Harmaline; Male; Mice; Mice, Inbred DBA; Ouabain; Papio; Pentylenetetrazole; Picrotoxin; Rats; Riluzole; Seizures; Synaptic Transmission; Thiazoles | 1985 |
Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Anticonvulsants; Bicuculline; Electroshock; Male; Muscimol; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1986 |
Sex differences in the sensitivity of CBA mice to convulsions induced by GABA antagonists are age-dependent.
Topics: Aging; Animals; Bicuculline; Female; GABA Antagonists; Male; Mice; Mice, Inbred CBA; Picrotoxin; Seizures; Sex Factors; Strychnine | 1987 |
Evidence for increased activity of mouse brain fatty acid cyclooxygenase following drug-induced convulsions.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Dinoprost; Dinoprostone; Ethosuximide; Female; Kinetics; Mice; Microsomes; Pentylenetetrazole; Picrotoxin; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Prostaglandins F; Seizures; Strychnine | 1987 |
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotoxin; Punishment; Seizures | 1987 |
Post-training administration of GABAergic antagonists enhances retention of aversively motivated tasks.
Topics: Animals; Bicuculline; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Electroshock; GABA Antagonists; Male; Mice; Mice, Inbred Strains; Picrotoxin; Reinforcement, Psychology; Seizures | 1988 |
Changes in GABA content of the brain and sensitivity to GABA-antagonists during and after repetitive treatment of rats with diphenilhydantoin.
Topics: Animals; Brain; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1988 |
Suppression and induction of epileptic activity by neuronal grafts.
Topics: Animals; Denervation; Epilepsy; Hippocampus; Locus Coeruleus; Neurons; Picrotoxin; Rats; Reference Values; Seizures | 1988 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures; Substance Withdrawal Syndrome | 1988 |
Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Bicuculline; Carbolines; Convulsants; Drug Interactions; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1988 |
Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Injections; Isoniazid; Mice; Osmolar Concentration; Pentylenetetrazole; Picrotoxin; Seizures; Vigabatrin | 1988 |
GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists.
Topics: 3-Mercaptopropionic Acid; Allylglycine; Animals; Anticonvulsants; Barbiturates; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Picrotoxin; Rats; Seizures; Semicarbazides | 1987 |
Differential effects of caffeine, picrotoxin, and pentylenetetrazol on hippocampal afterdischarge activity and wet dog shakes.
Topics: Animals; Caffeine; Electroencephalography; Hippocampus; Male; Membrane Potentials; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1987 |
Seizure activity and cortical spreading depression monitored by an extrinsic potential-sensitive molecular probe.
Topics: Animals; Bicuculline; Cerebral Cortex; Cortical Spreading Depression; Electrophysiology; Female; Gerbillinae; Male; Mitochondria; Picrotoxin; Potassium Chloride; Seizures | 1987 |
Effects of neurohypophyseal peptide hormones on alcohol dependence and withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Lypressin; Male; Mice; Oxytocin; Picrotoxin; Psychoses, Alcoholic; Seizures | 1987 |
Kindling by repeated intraperitoneal or intracerebral injection of picrotoxin transfers to electrical kindling.
Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Injections; Injections, Intraperitoneal; Kindling, Neurologic; Male; Picrotoxin; Rats; Seizures | 1987 |
Electrical stimulation can inhibit synchronized neuronal activity.
Topics: Animals; Electric Stimulation; Hippocampus; Kinetics; Neurons; Penicillins; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1986 |
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
Topics: Animals; Anticonvulsants; Bicuculline; Electroshock; Ethosuximide; Male; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures; Valproic Acid | 1985 |
Sex related differences in the response of mice, rats and cats to administration of picrotoxin.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Electrophysiology; Female; Male; Mice; Mice, Inbred CBA; Motor Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Sex Characteristics; Spinal Cord | 1986 |
Injections of picrotoxin and bicuculline into the amygdaloid complex of the rat: an electroencephalographic, behavioural and morphological analysis.
Topics: Amygdala; Animals; Behavior, Animal; Bicuculline; Drug Interactions; Electroencephalography; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1985 |
Proceedings: Potentiation of picrotoxin-induced convulsions in mice by antidepressants. Specificity of the effect.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Central Nervous System Stimulants; Drug Synergism; Male; Mice; Mice, Inbred Strains; Picrotoxin; Seizures; Tranquilizing Agents | 1974 |
The action of convulsants on neuronal and gross wave activity in the thalamus and in the cortex.
Topics: Animals; Cats; Cerebral Cortex; Injections, Intravenous; Neurons; Pentylenetetrazole; Picrotoxin; Seizures; Thalamus | 1963 |
On the mechanisms of picrotoxin epileptic seizure (macro- and micro-electrode investigations).
Topics: Action Potentials; Animals; Cats; Cerebral Cortex; Electroencephalography; Electrophysiology; Neurons; Picrotoxin; Seizures | 1969 |
The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrocardiography; Electroencephalography; Picrotoxin; Rabbits; Respiration; Seizures | 1970 |
The developing animal as a model.
Topics: Age Factors; Animals; Barbiturates; Brain; Central Nervous System; Electric Stimulation; Electroshock; Fetus; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Reflex; Seizures; Spinal Cord; Strychnine; Synaptic Transmission; Time Factors | 1969 |
Proceedings: Presynaptic inhibition and the depressant actions of GABA and glycine in the feline cuneate nucleus: changes related to electrographic seizure activity.
Topics: Alkaloids; Aminobutyrates; Animals; Cats; Dioxoles; Electroencephalography; Glycine; Injections, Intravenous; Iontophoresis; Isoquinolines; Medulla Oblongata; Neural Inhibition; Picrotoxin; Seizures; Sensory Receptor Cells; Strychnine; Synaptic Transmission | 1973 |
Chemical studies in relation to convulsive conditions. Effect of Telodrin on the liberation and utilization of ammonia in rat brain.
Topics: Amino Acids; Ammonia; Animals; Benzofurans; Brain; Central Nervous System Stimulants; Chromatography, Paper; Electric Stimulation; Glutamates; Glutamine; Ketoglutaric Acids; Picrotoxin; Pyruvates; Rats; Seizures | 1964 |
Pulmonary changes with convulsions induced by drugs and oxygen at high pressure.
Topics: Amino Alcohols; Animals; Central Nervous System Stimulants; Chlorpromazine; Curare; Dibenzylchlorethamine; Hyperbaric Oxygenation; Lung; Oxygen; Pentobarbital; Pentylenetetrazole; Picrotoxin; Pulmonary Edema; Rats; Seizures; Sympatholytics | 1966 |
Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.
Topics: Aluminum; Aminobutyrates; Animals; Bemegride; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Diphenhydramine; Electroencephalography; Ethers; Fluorine; Haplorhini; Hydroxides; Hydroxylamines; Isoflurophate; Pentylenetetrazole; Picrotoxin; Pyridoxine; Reserpine; Seizures; Semicarbazides; Strychnine | 1969 |
Hydrazide-induced seizures and cerebral levels of gamma-aminobutyric acid: a re-evaluation.
Topics: Age Factors; Aminobutyrates; Animals; Animals, Newborn; Brain Chemistry; Central Nervous System Stimulants; Centrifugation; Chickens; Freeze Drying; Picrotoxin; Seizures; Semicarbazides; Strychnine; Thiosemicarbazones | 1970 |
Effects of drugs acting alone and in combination on the motor activity of intact mice.
Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central Nervous System Stimulants; Chlorpromazine; Diazepam; Diphenhydramine; Female; Glutamates; Hydroxybutyrates; Lactones; Meperidine; Meprobamate; Mice; Motor Activity; Nikethamide; Phenobarbital; Picrotoxin; Promethazine; Reflex; Scopolamine; Seizures; Strychnine; Tranquilizing Agents | 1970 |
Effects of general stimulant drugs on the electrical responses of isolated slabs of cat's cerebral cortex.
Topics: Action Potentials; Animals; Bemegride; Caffeine; Cats; Central Nervous System Stimulants; Cerebral Cortex; Female; Glutamates; In Vitro Techniques; Male; Nikethamide; Picrotoxin; Seizures; Stimulation, Chemical; Strychnine | 1970 |
Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine.
Topics: Amides; Amino Acids; Animals; Bemegride; Brain; Brain Chemistry; Caffeine; Carbon Isotopes; Central Nervous System; Depression, Chemical; Glutamine; Hexobarbital; Liver; Male; Mice; Pentylenetetrazole; Picrotoxin; Piperidines; Seizures; Sleep; Strychnine | 1971 |
Resistance to picrotoxin poisoning induced by catatoxic steroids.
Topics: Anabolic Agents; Androstanes; Animals; Cholesterol; Desoxycorticosterone; Ethylestrenol; Female; Fluorine; Ketosteroids; Oxandrolone; Picrotoxin; Poisoning; Prednisolone; Pregnanediones; Pregnanes; Progesterone; Rats; Seizures; Spironolactone; Steroids; Triamcinolone | 1970 |
Convulsive activity in garter snakes.
Topics: Animals; Behavior, Animal; Bemegride; Body Temperature; Brain; Central Nervous System; Central Nervous System Stimulants; Electroencephalography; Evoked Potentials; Pentylenetetrazole; Picrotoxin; Receptors, Adrenergic; Receptors, Cholinergic; Seizures; Snakes; Strychnine; Synapses | 1972 |
Inhibition of post-decapitation convulsions by reserpine.
Topics: Animals; Cervical Vertebrae; Cordotomy; Male; Norepinephrine; Pentylenetetrazole; Picrotoxin; Rats; Reserpine; Seizures; Strychnine | 1973 |
Changes in sensitivity to convulsion in mice with olfactory bulb ablation.
Topics: Animals; Cyclohexanes; Electroshock; Limbic System; Male; Mice; Olfactory Bulb; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1972 |
Some characteristics of cortical inhibition induced by local stimulation and by an acute seizure focus in the cat.
Topics: Animals; Cats; Cerebral Cortex; Injections, Intravenous; Iontophoresis; Isoquinolines; Neural Inhibition; Neurons; Penicillin G; Picrotoxin; Seizures | 1972 |
Effect of lithium on acute oxygen toxicity and associated changes in brain gamma-aminobutyric acid.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Hyperbaric Oxygenation; Lithium; Magnesium; Male; Manganese; Oxygen; Pentylenetetrazole; Picrotoxin; Pulmonary Edema; Rats; Seizures; Strychnine; Thiosemicarbazones; Zinc | 1973 |
Glutamate and aspartate in cortical subarachnoid fluid in relation to convulsive activity.
Topics: Animals; Aspartic Acid; Azoles; Brain; Dogs; Glutamates; Methionine Sulfoximine; Picrotoxin; Seizures; Subarachnoid Space; Thiosemicarbazones | 1973 |
Some studies on the convulsant action of folic acid.
Topics: Alkaloids; Animals; Auditory Threshold; Cerebral Ventricles; Dioxoles; Electroshock; Folic Acid; Folic Acid Antagonists; Glutamates; Injections; Injections, Intravenous; Isoquinolines; Mice; Ouabain; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine | 1973 |
Convulsions elicited by handling: a sensitive method of measuring CNS excitation in mice treated with reserpine or convulsant drugs.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Ethanol; Humans; Male; Mice; Pentylenetetrazole; Picrotoxin; Reserpine; Seizures; Strychnine; Substance Withdrawal Syndrome; Time Factors | 1973 |
Actions of GABA, picrotoxin and bicuculline on adrenal medulla.
Topics: Acetylcholine; Adrenal Glands; Adrenal Medulla; Alkaloids; Aminobutyrates; Animals; Calcium; Catecholamines; Cattle; Dioxoles; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Isoquinolines; Picrotoxin; Potassium; Seizures; Strychnine | 1974 |
Changes in local excitability produced by intrahippocampal injections of thiosemicarbazide and GABA.
Topics: Aminobutyrates; Animals; Cats; Electroencephalography; Evoked Potentials; Hippocampus; Male; Picrotoxin; Seizures; Semicarbazides; Stereotaxic Techniques; Strychnine; Tubocurarine | 1967 |
Effects of N, N' -diphenyldicarbamate-1,1-demethylol cyclopentane (Carmalon) on the spinal cord reflexes.
Topics: Animals; Atropine; Barbiturates; Cyclopentanes; Depression, Chemical; Electric Stimulation; Male; Mephenesin; Mice; Pentylenetetrazole; Picrotoxin; Reflex; Seizures; Sleep; Spinal Cord; Strychnine | 1968 |
The convulsive action of 2,5-dicarbethoxy 3,4-dihydroxythiophane (dicetol).
Topics: Acetylcholine; Animals; Blood Pressure; Brain Chemistry; Cats; Depression, Chemical; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Mice; Muscles; Pentobarbital; Picrotoxin; Rabbits; Rats; Reserpine; Respiration; Seizures; Sleep; Thiophenes | 1968 |
[Action of diazepam on the spinal cord reflex, with special reference to dorsal root reflex].
Topics: Animals; Cats; Chlordiazepoxide; Denervation; Diazepam; Electric Stimulation; Evoked Potentials; Female; Injections, Intraperitoneal; Male; Mice; Picrotoxin; Reflex; Seizures; Solvents; Spinal Cord; Strychnine; Synapses; Time Factors | 1969 |
Effects of various conditions on the movement of carbon atoms derived from glucose into and out of protein in rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Cerebral Cortex; Depression, Chemical; Glucose; Glutamates; Hypoxia; Injections, Intravenous; Insulin; Male; Metabolism; Nerve Tissue Proteins; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stimulation, Chemical; Time Factors | 1970 |
Incorporation of carbon atoms from glucose into free amino acids in brain under normal and altered conditions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Depression, Chemical; Glucose; Glutamates; Glutamine; Glycolates; Hypoxia; Injections, Intravenous; Lactates; Male; Metabolism; Methods; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stimulation, Chemical; Time Factors | 1970 |
Protein-bound amide groups in brain.
Topics: Amides; Ammonia; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Cerebral Cortex; Glucose; Glutamates; Glutamine; Hydrochloric Acid; Nerve Tissue Proteins; Pentobarbital; Peptide Hydrolases; Picrotoxin; Protein Binding; Rats; Seizures; Streptomyces | 1970 |
Effect of metal ions on oxygen toxicity.
Topics: Animals; Atmospheric Pressure; Cobalt; Hydroxylamines; Hyperbaric Oxygenation; Injections, Intraperitoneal; Ions; Lung; Male; Manganese; Metals; Methods; Oxygen; Pentylenetetrazole; Picrotoxin; Potassium; Pulmonary Edema; Rats; Seizures; Strychnine; Thiosemicarbazones; Zinc | 1970 |
Concerning the depressant activity of analeptics (pentylenetetrazol, bemegride, nikethamide, picrotoxin).
Topics: Anesthesia; Animals; Barbiturates; Bemegride; Depression, Chemical; Guinea Pigs; Nikethamide; Nitrous Oxide; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1970 |
[Introduction of mass psychology in animals to pharmacology. 7. Mutural relation in convulsion of El-mice and drugs acting on the central nervous system].
Topics: Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Hydantoins; Imidazoles; Mice; Phenobarbital; Picrotoxin; Psychology; Seizures | 1970 |
The effect of intraperitoneal injections of hyperosmotic solutions on convulsions induced by drugs and hyperbaric oxygen.
Topics: Aminobutyrates; Animals; Brain Diseases; Dehydration; Glucose; Hyperbaric Oxygenation; Hypertonic Solutions; Injections, Intraperitoneal; Male; Osmolar Concentration; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Semicarbazides; Urea | 1968 |
Convulsions and the gamma-aminobutyric acid content of rat brain.
Topics: Alanine; Aminobutyrates; Animals; Brain Chemistry; Hyperbaric Oxygenation; Osmolar Concentration; Oxygen; Picrotoxin; Rats; Seizures | 1968 |
Further studies on chemically induced siezures and their antagonism by anticonvulsants during postnatal development in the mouse.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Trimethadione | 1968 |
Electrophysiological investigations on homopantothenic acid.
Topics: Animals; Brain; Cats; Cerebral Cortex; Electroencephalography; Electrophysiology; Male; Pantothenic Acid; Pentylenetetrazole; Picrotoxin; Rabbits; Seizures; Time Factors | 1968 |
Macro- and micro-electrode investigations on the mechanisms of pycrotoxine epileptic seizure.
Topics: Animals; Cats; Electroencephalography; Picrotoxin; Seizures | 1968 |
On the effect of cardiazol and picrotoxin on cats with crossed blood circulation.
Topics: Animals; Blood Transfusion; Cats; Electroencephalography; Pentylenetetrazole; Picrotoxin; Seizures | 1968 |
Effect of picrotoxin and pyramidon in cats with strychnine cortical focus during crossed blood circulation.
Topics: Aminopyrine; Animals; Blood Transfusion; Cats; Electroencephalography; Picrotoxin; Seizures; Strychnine | 1968 |
[On the inflence of fluid volume on the efficacy of bemegride, Pentetrazole and picrotoxin in phenobarbital poisoning].
Topics: Animals; Bemegride; Mice; Pentylenetetrazole; Pharmaceutical Vehicles; Phenobarbital; Picrotoxin; Seizures; Sodium Chloride; Solutions; Suspensions | 1968 |
Pharmacological significances of peptidase and proteinase in the brain. I. Enzymatic inactivation of bradykinin in rat brain.
Topics: Animals; Biological Assay; Bradykinin; Brain; Brain Stem; Carboxypeptidases; Cell Nucleus; Cerebellum; Cerebral Cortex; Depression, Chemical; Endopeptidases; Hydrogen-Ion Concentration; Male; Microsomes; Mitochondria; Muscle, Smooth; Nerve Tissue Proteins; Pentylenetetrazole; Peptide Hydrolases; Picrotoxin; Rats; Seizures; Stimulation, Chemical; Temperature | 1969 |
Elevation of gamma-aminobutyric acid in brain with amino-oxyacetic acid and susceptibility to convulsive seizures in mice: a quantitative re-evaluation.
Topics: Acetates; Adenosine Triphosphate; Aminobutyrates; Animals; Brain; Carboxy-Lyases; Electroconvulsive Therapy; In Vitro Techniques; Mice; Nerve Endings; Pentylenetetrazole; Picrotoxin; Seizures; Strychnine | 1966 |