picrotoxin has been researched along with Epilepsy in 124 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (19.35) | 18.7374 |
| 1990's | 41 (33.06) | 18.2507 |
| 2000's | 44 (35.48) | 29.6817 |
| 2010's | 10 (8.06) | 24.3611 |
| 2020's | 5 (4.03) | 2.80 |
| Authors | Studies |
|---|---|
| Distler, U; Ihbe, N; Kürten, T; Mittmann, T; Sielaff, M; Tenzer, S; Ueberbach, T | 1 |
| Adassi, MB; Foutsop, AF; Kom, TD; Ngo Bum, E; Ngoupaye, GT; Yassi, FB | 1 |
| Bao, X; Cai, J; Han, QT; Li, F; Qu, J; Shi, Q; Wang, XL; Yang, WQ; Yu, SS; Zang, C; Zhang, CJ; Zhang, D; Zhou, L | 1 |
| Carmona-Aparicio, L; González-Trujano, ME; Martínez-Vargas, D; Santos-Valencia, F; Urbina-Trejo, E; Villasana-Salazar, B | 1 |
| Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD | 1 |
| Dunn, RL; Feng, Y; Forcelli, PA; Hammack, RJ; Huizenga, MN; Pak, DTS; Queenan, BN; Santos, VR; Vicini, S | 1 |
| Anisimova, VA; Grechko, OY; Kalitin, KY; Matukhno, AE; Spasov, AA; Sukhov, AG | 1 |
| Kubová, H; Mareš, P | 1 |
| Araújo, DA; Claudino, Fde S; de Almeida, RN; de Sousa, DP; Leite, JR; Mattei, R; Nóbrega, FF | 1 |
| Faria, LC; Fuortes, MG; Merlin, LR | 1 |
| Koyama, R; Matsuki, N; Nakahara, S; Tamura, M | 1 |
| Bailabar, T; Bum, EN; Hiana, IR; Moto, FC; Nkainsa, LA; Rakotonirina, A; Rakotonirina, SV; Seke Etet, PF; Seyni, P; Taiwe, GS | 1 |
| Mucke, L; Palop, JJ | 1 |
| Cristino, L; Di Marzo, V; Drago, F; Leggio, GM; Micale, V; Petrosino, S; Tamburella, A | 1 |
| Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M | 1 |
| Jia, XM; Liu, CY; Pei, L; Pei, YR; Wang, Y | 1 |
| Feng, ZY; Tian, C; Wang, Y; Xing, HY; Zheng, XJ | 1 |
| Doretto, MC; Drumond, LE; Guidine, PA; Kushmerick, C; Massensini, AR; Moraes, MF | 1 |
| Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R | 1 |
| Baxendale, S; Cunliffe, VT; Fox, J; Harrison, MR; Holdsworth, CJ; Ingham, PW; Meza Santoscoy, PL; Parkin, CA | 1 |
| Kombian, SB; Phillips, OA | 1 |
| Longacher, JM; Staley, KJ; Yee, AS | 1 |
| Tian, FF; Xie, GJ; Yang, QD | 1 |
| Bikson, M; Durand, DM; Lian, J; Sciortino, C; Stacey, WC | 1 |
| BURGERMEISTER-GUEX, G; DUCOMMUN, M; FROMMEL, E; RADOUCO-THOMAS, C | 1 |
| CHUSID, JG; KOPELOFF, LM; KOPELOFF, N | 1 |
| Ma, HT; Wu, CH; Wu, JY | 1 |
| Merlin, LR; Rico, MJ | 1 |
| Tang, YH; Zheng, Y; Zhou, H | 2 |
| de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S | 1 |
| Namiki, A; Ohmori, H; Sato, Y | 1 |
| Durand, DM; Feng, Z | 1 |
| Buznego, MT; Pérez-Saad, H | 3 |
| Budzińska, K | 1 |
| Acharya, MM; Katyare, SS | 1 |
| Godlevskii, LS; Kobolev, EV | 1 |
| Errington, AC; Lees, G; Stöhr, T | 1 |
| Hitti, FL; Kim, U; Lee, KH; Leiter, JC; Roberts, DW; Shalinsky, MH | 1 |
| Kullmann, DM; Scimemi, A; Semyanov, A; Sperk, G; Walker, MC | 1 |
| Plenz, D | 1 |
| Sierra-Marcuño, G; Sierra-Paredes, G; Vázquez-López, A | 1 |
| Broberg, M; Nilsson, M; Pope, KJ; Wallace, A; Willoughby, JO; Wilson, J | 1 |
| Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS | 1 |
| Jiang, K; Shui, Q; Yu, Z | 1 |
| Pericić, D; Strac, DS; Vlainić, J | 1 |
| Choi, SY; Choi, UK; Kang, JH; Kang, TC; Kim, DW; Kim, HT; Kim, JE; Kwak, SE; Kwon, OS; Lee, SJ | 1 |
| Hablitz, JJ | 2 |
| Dudek, FE; Snow, RW | 1 |
| Al-Sayegh, A; Ebadi, M; Hammad, HM; Swanson, S | 1 |
| Kofman, O; Mintz, M; Myslobodsky, MS | 1 |
| Myslobodsky, MS; Valenstein, ES | 1 |
| Merlin, LR; Taylor, GW; Wong, RK | 1 |
| Crichlow, EC; Kim, JS | 1 |
| Gerfin-Moser, A; Grogg, F; Rietschin, L; Streit, P; Thompson, SM | 1 |
| Aliev, AN; Aliev, MN; Mamedbeĭli, TN; Rzaev, RN | 1 |
| Rutecki, PA | 1 |
| Hablitz, JJ; Rucker, F; Sutor, B; ten Bruggencate, G | 1 |
| Köhling, R; Speckmann, EJ; Straub, H | 1 |
| Mott, DD; Stasheff, SF; Wilson, WA | 1 |
| Jefferys, JG; Miles, R; Traub, RD | 1 |
| Müller, M | 1 |
| Gutnick, MJ; Wadman, WJ | 1 |
| Dorce, VA; Sandoval, MR | 1 |
| Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS | 1 |
| Bijak, M; Smiałowska, M; Sopala, M; Tokarski, K | 1 |
| Rasmussen, PA; Rutecki, PA; Yang, Y | 1 |
| Ikegaya, Y; Nishiyama, N; Saito, H; Yoshida, M | 1 |
| Coulter, DA; DeLorenzo, RJ; Gibbs, JW; Sombati, S | 1 |
| Corrèges, P; Duport, S; Stoppini, L | 1 |
| Merlin, LR; Wong, RK | 1 |
| Colmers, WF; Klapstein, GJ | 1 |
| Marinelli, S; Sagratella, S; Tebano, MT | 1 |
| Connors, BW; Telfeian, AE | 2 |
| Gean, PW; Lu, KT | 1 |
| Bergold, PJ; Merlin, LR; Wong, RK | 1 |
| Brusentsov, AI; Godlevskiĭ, LS; Moroz, VV; Pomazanova, TN; Shandra, AA; Suprun, SA | 1 |
| Ikegaya, Y | 1 |
| Merlin, LR | 2 |
| Anic, T; Aralica, G; Dodig, G; Duplancie, B; Jelovac, N; Marovic, A; Mise, S; Perovic, D; Petek, M; Pigac, B; Prkacin, I; Rucman, R; Sebecic, B; Seiwerth, S; Sikiric, P; Slobodnjak, Z; Stancic-Rokotov, D; Turkovic, B; Ziger, T; Zoricic, I | 1 |
| Galoyan, SM; Merlin, LR | 1 |
| da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP | 1 |
| Senra-Vidal, A; Sierra-Marcuño, G; Sierra-Paredes, G | 1 |
| Bikson, M; Durand, DM; Hahn, PJ; Lian, J; Sciortino, C; Stacey, WC | 1 |
| Karnup, S; Stelzer, A | 1 |
| Wong, M; Yamada, KA | 1 |
| Chang, CK; Lin, MT | 1 |
| Cvitanović, P; Mogul, DJ; Slutzky, MW | 1 |
| Jayakumar, AR; Vanaja, P | 1 |
| Tan, M; Tan, U | 1 |
| Hamani, C; Mello, LE | 1 |
| Bohuslav, T; Kubová, M; Mares, P | 1 |
| Berg-Johnsen, J; Hegstad, E; Langmoen, IA | 1 |
| Brady, RJ; Smith, KL; Swann, JW | 1 |
| Hablitz, JJ; Lee, WL | 3 |
| Dreier, JP; Heinemann, U | 1 |
| Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Shandra, AA; Vikhrestiuk, SL | 1 |
| Kryzhanovskiĭ, GN; Shandra, AA; Sudakov, KV | 1 |
| Aksent'ev, SB; Levinskiĭ, MV | 1 |
| Johnston, D; Lebeda, FJ; Rutecki, PA | 1 |
| Heinemann, U; Köhr, G | 1 |
| Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Mazarati, AM; Shandra, AA | 1 |
| Depaulis, A; Lee, RJ; Lomax, P; Olsen, RW | 1 |
| Hablitz, JJ; Sutor, B | 1 |
| Bayardo, F; Buzsáki, G; Gage, FH; Ponomareff, GL; Ruiz, R | 1 |
| Godlevskiĭ, LS; Karganov, MIu; Kryzhanovskiĭ, GN; Lutsenko, VK; Shandra, AA | 1 |
| Hablitz, JJ; Heinemann, U | 2 |
| Dingledine, R; King, GL | 1 |
| Jones, RS | 1 |
| Thomson, AM; West, DC | 1 |
| Knowles, WD; Strowbridge, BW; Traub, RD | 1 |
| Bayardo, F; Buzsáki, G; Gage, FH; Ponomareff, G; Shaw, T | 1 |
| Larson-Prior, LJ; Slater, NT | 1 |
| Gean, PW; Shinnick-Gallagher, P | 1 |
| Saito, S | 1 |
| Tudor, I | 1 |
4 review(s) available for picrotoxin and Epilepsy
| Article | Year |
|---|---|
Epilepsy and cognitive impairments in Alzheimer disease.
Topics: Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Apolipoprotein E4; Brain; Cognition Disorders; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; GABA Antagonists; Genetic Carrier Screening; Hippocampus; Humans; Mice; Mice, Transgenic; Nerve Net; Neural Inhibition; Picrotoxin; Synaptic Transmission; tau Proteins | 2009 |
[GABA receptor complex and the mechanisms of action of various anticonvulsants (review of the literature)].
Topics: Animals; Anticonvulsants; Barbiturates; Brain; Drug Evaluation; Epilepsy; gamma-Aminobutyric Acid; Humans; Picrotoxin; Rats; Receptors, GABA-A | 1990 |
[Biochemistry of epilepsy].
Topics: Acetylcholine; Aminobutyrates; Animals; Brain; Electroencephalography; Epilepsy; Glutamates; Glutamine; Humans; Muscle Cramp; Pentylenetetrazole; Picrotoxin; Seizures | 1968 |
[Biochemical aspects of seizures in convulsive diseases].
Topics: Ammonia; Animals; Biochemical Phenomena; Biochemistry; Cell Membrane; Epilepsy; Fatty Acids; Humans; Methionine; Nervous System; Neurons; Picrotoxin; Potassium; Seizures; Sodium; Strychnine | 1969 |
120 other study(ies) available for picrotoxin and Epilepsy
| Article | Year |
|---|---|
GABA
Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy-Related Proteins; Brain Injuries, Traumatic; Disease Models, Animal; Epilepsy; Mice; Picrotoxin; Receptors, GABA-A; Seizures | 2022 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin; Pilocarpine; Plant Extracts; Seizures; Strychnine; Water | 2023 |
The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin.
Topics: Animals; Calcineurin; Epilepsy; Mice; Picrotoxin; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Seizures | 2023 |
Pharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Male; Medicine, Traditional; Mice; Mortality; Pentylenetetrazole; Picrotoxin; Plant Extracts; Ruta; Seizures | 2021 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mice; Pentylenetetrazole; Phytochemicals; Picrotoxin; Plant Bark; Plant Extracts; Plant Stems; Psychotria; Rats, Wistar; Seizures; Semicarbazides; Sleep; Sleep Latency; Strychnine; Water | 2021 |
Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis.
Topics: Animals; Cells, Cultured; Central Nervous System Stimulants; Convulsants; Disease Models, Animal; Disks Large Homolog 4 Protein; Dose-Response Relationship, Drug; Embryo, Mammalian; Epilepsy; Green Fluorescent Proteins; Hippocampus; Kindling, Neurologic; Male; Mice; Narcotic Antagonists; Narcotics; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Opioid, kappa; Repressor Proteins; Synapses; Synaptophysin; Tetrodotoxin; Transfection; Tumor Suppressor Proteins | 2018 |
GABAergic Mechanism of Anticonvulsive Effect of Chemical Agent RU-1205.
Topics: Animals; Anticonvulsants; Benzimidazoles; Brain; Epilepsy; Mice; Morpholines; Picrotoxin; Rats; Receptors, GABA-A | 2018 |
GABAB, not GABAA receptors play a role in cortical postictal refractoriness.
Topics: Animals; Azepines; Bicuculline; Cerebral Cortex; Electric Stimulation; Electrodes, Implanted; Epilepsy; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Male; Organophosphorus Compounds; Pentylenetetrazole; Picrotoxin; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B | 2015 |
Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Cyclohexane Monoterpenes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Epilepsy; Flumazenil; GABA Modulators; In Vitro Techniques; Male; Mice; Monoterpenes; Pentylenetetrazole; Physical Stimulation; Picrotoxin; Rats; Rats, Wistar; Sciatic Nerve | 2008 |
Impact of protein kinase C activation on epileptiform activity in the hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Atropine; Benzoates; Benzophenanthridines; Enzyme Activation; Epilepsy; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Phorbol 12,13-Dibutyrate; Picrotoxin; Protein Kinase C; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Signal Transduction | 2008 |
Neuronal hyperactivity sustains the basal dendrites of immature dentate granule cells: time-lapse confocal analysis using hippocampal slice cultures.
Topics: Action Potentials; Analysis of Variance; Animals; Calbindins; Cell Shape; Dendrites; Electroporation; Epilepsy; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; In Vitro Techniques; Microscopy, Confocal; Neurons; Picrotoxin; Pseudopodia; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Sodium Channel Blockers; Tetrodotoxin | 2009 |
Validation of anticonvulsant and sedative activity of six medicinal plants.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Excitatory Amino Acid Agonists; Hypnotics and Sedatives; Isoniazid; Male; Medicine, African Traditional; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Plants, Medicinal; Sleep Initiation and Maintenance Disorders; Stereotyped Behavior; Strychnine | 2009 |
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Capsaicin; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Epilepsy; GABA Antagonists; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Picrotoxin; Piperidines; Pyrazoles; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Dopamine D3; Serotonin; TRPV Cation Channels | 2009 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbred Strains; Pakistan; Pentylenetetrazole; Phenytoin; Picrotoxin; Ranunculaceae; Seizures; Skin Neoplasms | 2010 |
[Effects of Tianbingtiaodu capsule on improvement of learning and memory abilities and expression of NMDAR1 of epileptic rats in the hippocampus].
Topics: Animals; Behavior, Animal; Capsules; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Epilepsy; Hippocampus; Immunohistochemistry; Learning; Male; Memory; Neuroprotective Agents; Picrotoxin; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Changes of paired-pulse evoked responses during the development of epileptic activity in the hippocampus.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Epilepsy; Evoked Potentials; GABA-A Receptor Antagonists; Hippocampus; Humans; Neurons; Picrotoxin; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Time Factors | 2011 |
Reduced hippocampal GABAergic function in Wistar audiogenic rats.
Topics: Animals; CA1 Region, Hippocampal; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Male; Neural Inhibition; Picrotoxin; Rats; Rats, Wistar; Synapses; Synaptic Transmission | 2011 |
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Compounding; Drug Interactions; Epilepsy; Gas Chromatography-Mass Spectrometry; Lipid Peroxidation; Male; Manihot; Motor Activity; Muscarinic Agonists; Pentylenetetrazole; Phytotherapy; Picrotoxin; Pilocarpine; Plant Preparations; Random Allocation; Rats; Rats, Wistar; Seizures; Superoxide Dismutase | 2011 |
Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures.
Topics: Animals; Anticonvulsants; Central Nervous System; Disease Models, Animal; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Epilepsy; Gene Expression Regulation, Developmental; In Situ Hybridization; Larva; Motor Activity; Muscles; Organ Specificity; Pentylenetetrazole; Picrotoxin; Small Molecule Libraries; Zebrafish | 2012 |
Novel actions of oxazolidinones: in vitro screening of a triazolyloxazolidinone for anticonvulsant activity.
Topics: Action Potentials; Animals; Anticonvulsants; Central Nervous System Stimulants; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Magnesium; Oxazolidinones; Picrotoxin; Rats; Rats, Sprague-Dawley | 2013 |
Convulsant and anticonvulsant effects on spontaneous CA3 population bursts.
Topics: Acetazolamide; Action Potentials; Animals; Anticonvulsants; Convulsants; Epilepsy; Hippocampus; Models, Neurological; Organ Culture Techniques; Pentobarbital; Picrotoxin; Pyramidal Cells; Rats; Rats, Wistar | 2003 |
[Kindling model of SD rats induced by injection of PTX intraperitoneally].
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Injections, Intraperitoneal; Kindling, Neurologic; Male; Picrotoxin; Random Allocation; Rats; Rats, Sprague-Dawley | 2001 |
Local suppression of epileptiform activity by electrical stimulation in rat hippocampus in vitro.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Electricity; Electrodes; Epilepsy; Extracellular Space; Hippocampus; In Vitro Techniques; Membrane Potentials; Osmolar Concentration; Picrotoxin; Potassium; Rats; Rats, Sprague-Dawley | 2003 |
[The point of peripheral impact of coramine, cardiazol, picrotoxin and scilliroside and their relation to cholinergic action. I].
Topics: Bufanolides; Cholinergic Agents; Disease; Epilepsy; Muscles; Nikethamide; Pentylenetetrazole; Picrotoxin; Plants, Medicinal; Vagus Nerve | 1953 |
Convulsant threshold dosages of picrotoxin and strychnine sulfate in normal and epileptic monkeys.
Topics: Animals; Convulsants; Epilepsy; Haplorhini; Picrotoxin; Strychnine; Sulfates | 1957 |
Initiation of spontaneous epileptiform events in the rat neocortex in vivo.
Topics: Animals; Bicuculline; Epilepsy; Evoked Potentials; GABA-B Receptor Antagonists; Male; Neocortex; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-B | 2004 |
Evidence that phospholipase D activation prevents group I mGluR-induced persistent prolongation of epileptiform bursts.
Topics: Animals; Cyclopropanes; Cysteine; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; Glycine; Guinea Pigs; Methoxyhydroxyphenylglycol; Neurotransmitter Agents; Phospholipase D; Picrotoxin; Receptors, Metabotropic Glutamate | 2004 |
[Tutin-induced epileptiform discharge of CA1 pyramidal cells in rat hippocampal slices].
Topics: Animals; Electrophysiology; Epilepsy; Female; Hippocampus; Male; Picrotoxin; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2004 |
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Epilepsy; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Glutamic Acid; Guanosine; In Vitro Techniques; Injections, Intraventricular; Male; Neurons; Phenobarbital; Picrotoxin; Quinolinic Acid; Rats; Rats, Wistar | 2004 |
The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aminophylline; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theobromine; Xanthines | 2004 |
Decrease in synaptic transmission can reverse the propagation direction of epileptiform activity in hippocampus in vivo.
Topics: Animals; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Epilepsy; Evoked Potentials; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Neural Inhibition; Picrotoxin; Potassium; Rats; Rats, Sprague-Dawley; Reaction Time; Synaptic Transmission; Time Factors | 2005 |
Acute effect of an extract of Ambrosia paniculata (Willd.) O. E. Schultz (mugwort) in several models of experimental epilepsy.
Topics: Ambrosia; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Electroshock; Epilepsy; Exploratory Behavior; Isoniazid; Male; Mice; Motor Activity; Penicillins; Phytotherapy; Picrotoxin; Plant Preparations; Psychomotor Performance; Rats; Reaction Time; Time Factors; Tubocurarine | 2004 |
Hypoglossal and phrenic nerve responses to changes in oxygen tension during picrotoxin-induced seizures in the rat.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hyperoxia; Hypoglossal Nerve; Hypoxia; Male; Motor Activity; Oxygen; Phrenic Nerve; Picrotoxin; Rats; Respiration | 2004 |
Structural and functional alterations in mitochondrial membrane in picrotoxin-induced epileptic rat brain.
Topics: Animals; Brain; Cell Death; Cell Respiration; Convulsants; Cytochromes; Disease Models, Animal; Electron Transport Chain Complex Proteins; Energy Metabolism; Epilepsy; Intracellular Membranes; Male; Membrane Fluidity; Membrane Lipids; Membrane Potentials; Mitochondria; Mitochondrial Proton-Translocating ATPases; Nerve Degeneration; Oxidative Phosphorylation; Picrotoxin; Rats | 2005 |
The effects of L-DOPA and transcranial magnetic stimulation on behavioral reactions in kindled rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dopamine Agents; Electric Stimulation; Electromagnetic Fields; Epilepsy; Exploratory Behavior; Feeding Behavior; Female; Kindling, Neurologic; Levodopa; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Sexual Behavior, Animal | 2005 |
Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetamides; Animals; Anticonvulsants; Carbamazepine; Convulsants; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; Female; In Vitro Techniques; Lacosamide; Male; Membrane Potentials; Patch-Clamp Techniques; Phenobarbital; Picrotoxin; Potassium Channel Blockers; Prohibitins; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Visual Cortex | 2006 |
Abolition of spindle oscillations and 3-Hz absence seizurelike activity in the thalamus by using high-frequency stimulation: potential mechanism of action.
Topics: Action Potentials; Animals; Deep Brain Stimulation; Epilepsy; Essential Tremor; Female; Ferrets; GABA Antagonists; Male; Neurons; Neurotransmitter Agents; Parkinson Disease; Periodicity; Picrotoxin; Seizures; Synaptic Membranes; Thalamus | 2005 |
Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug Interactions; Epilepsy; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Neural Inhibition; Neuronal Plasticity; Neurons; Nipecotic Acids; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tetrodotoxin | 2005 |
Comment on "Critical branching captures activity in living neural networks and maximizes the number of metastable states".
Topics: Animals; Cerebral Cortex; Epilepsy; Humans; Models, Neurological; Nerve Net; Neurons; Picrotoxin | 2005 |
A new rat model of acute seizures induced by tutin.
Topics: Action Potentials; Acute Disease; Animals; Brain; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Female; Injections, Intraventricular; Male; Picrotoxin; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Status Epilepticus | 2006 |
Behavioral and antiepileptic effect of acute administration of the extract of the aquatic plant Echinodorus berteroi (Sprengel) Fassett (upright burhead).
Topics: Alismataceae; Animals; Central Nervous System; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Electroshock; Epilepsy; Isoniazid; Male; Mice; Mice, Inbred Strains; Muscle Hypotonia; Penicillins; Phytotherapy; Picrotoxin; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Stereotyped Behavior | 2006 |
Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus.
Topics: Animals; Anticonvulsants; Calcineurin Inhibitors; Convulsants; Epilepsy; Hippocampus; Immunosuppressive Agents; Male; Perfusion; Phosphorylation; Picrotoxin; Rats; Rats, Sprague-Dawley; Tacrolimus | 2006 |
Preseizure increased gamma electroencephalographic activity has no effect on extracellular potassium or calcium.
Topics: Analysis of Variance; Animals; Brain; Calcium; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Extracellular Fluid; Kainic Acid; Male; Picrotoxin; Potassium; Rats; Rats, Sprague-Dawley; Spectrum Analysis | 2007 |
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Bicuculline; Cobalt; Convulsants; Electroshock; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epilepsy, Reflex; Excitatory Amino Acid Agonists; GABA Antagonists; Homocysteine; Kindling, Neurologic; Lacosamide; Male; Mice; N-Methylaspartate; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2007 |
The pattern of ATP-sensitive K+ channel subunits, Kir6.2 and SUR1 mRNA expressions in DG region is different from those in CA1-3 regions of chronic epilepsy induced by picrotoxin in rats.
Topics: Animals; Blotting, Western; Cerebral Cortex; Chronic Disease; Convulsants; Dentate Gyrus; Epilepsy; In Situ Hybridization; Kindling, Neurologic; Male; Picrotoxin; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2007 |
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Epilepsy; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Mice, Inbred CBA; Motor Activity; Pentylenetetrazole; Picrotoxin; Pyridines; Zolpidem | 2008 |
Behavioral and antiepileptic effects of acute administration of the extract of the plant Cestrum nocturnum Lin (lady of the night).
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Cestrum; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Exploratory Behavior; Hyperalgesia; Isoniazid; Male; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Stereotyped Behavior | 2008 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; Electroshock; Enzyme Inhibitors; Epilepsy; gamma-Aminobutyric Acid; Gerbillinae; Magnesium; Male; Mice; Mice, Inbred BALB C; Neurotoxicity Syndromes; Pentylenetetrazole; Picrotoxin; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution | 2008 |
Picrotoxin-induced epileptiform activity in hippocampus: role of endogenous versus synaptic factors.
Topics: Animals; Electric Stimulation; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Periodicity; Picrotoxin; Refractory Period, Electrophysiological; Synapses; Synaptic Transmission | 1984 |
Electrical fields directly contribute to action potential synchronization during convulsant-induced epileptiform bursts.
Topics: Action Potentials; Animals; Cortical Synchronization; Electromagnetic Fields; Epilepsy; Hippocampus; In Vitro Techniques; Picrotoxin; Rats | 1984 |
Dissociation between epileptic seizures induced by convulsant drugs and alteration in the concentrations of pyridoxal phosphate in rat brain regions.
Topics: 3-Mercaptopropionic Acid; Allylglycine; Animals; Bicuculline; Brain; Convulsants; Epilepsy; Male; Picrotoxin; Pyridoxal Kinase; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Strychnine | 1983 |
Pharmacologic analysis of the postictal immobility syndrome in the rat.
Topics: Animals; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Female; Haloperidol; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1981 |
Amygdaloid kindling and the GABA system.
Topics: 4-Aminobutyrate Transaminase; Amygdala; Animals; Electric Stimulation; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Seizures; Transaminases | 1980 |
Role of metabotropic glutamate receptor subtypes in the patterning of epileptiform activities in vitro.
Topics: Animals; Epilepsy; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Picrotoxin; Receptors, Metabotropic Glutamate; Time Factors | 1995 |
Clinical signs of ivermectin toxicity and the efficacy of antigabaergic convulsants as antidotes for ivermectin poisoning in epileptic chickens.
Topics: Animals; Antidotes; Carbolines; Chickens; Epilepsy; GABA Antagonists; Ivermectin; Pentylenetetrazole; Picrotoxin; Poultry Diseases | 1995 |
Alterations in glutamate but not GABAA receptor subunit expression as a consequence of epileptiform activity in vitro.
Topics: Animals; Autoradiography; Cells, Cultured; Epilepsy; Gene Expression; Glutamic Acid; Hippocampus; In Situ Hybridization; In Vitro Techniques; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; RNA, Messenger | 1995 |
[The role of lipid peroxidation in the pathogenesis of neuropathological syndromes and in experimental therapy].
Topics: Animals; Antioxidants; Bemegride; Brain Chemistry; Chorea; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Epilepsy; Female; GABA Agonists; Haloperidol; Hyperkinesis; Lipid Peroxidation; Male; Mice; Picrotoxin; Rats; Syndrome | 1994 |
Noradrenergic modulation of epileptiform activity in the hippocampus.
Topics: Adrenergic Agents; Adrenergic Antagonists; Animals; Epilepsy; Hippocampus; In Vitro Techniques; Norepinephrine; Picrotoxin; Potassium; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic | 1995 |
Spread of epileptiform activity in the immature rat neocortex studied with voltage-sensitive dyes and laser scanning microscopy.
Topics: Age Factors; Animals; Bicuculline; Culture Techniques; Epilepsy; Frontal Lobe; Membrane Potentials; Microscopy; Picrotoxin; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1994 |
Picrotoxin-induced epileptic activity in hippocampal and neocortical slices (guinea pig): suppression by organic calcium channel blockers.
Topics: Animals; Cerebral Cortex; Depression, Chemical; Epilepsy; Female; Flunarizine; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Picrotoxin; Receptors, GABA-A; Verapamil | 1994 |
Axon terminal hyperexcitability associated with epileptogenesis in vitro. II. Pharmacological regulation by NMDA and GABAA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Axons; Baclofen; Culture Techniques; Epilepsy; Evoked Potentials; Hippocampus; Kindling, Neurologic; Male; Neuronal Plasticity; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1993 |
Synaptic and intrinsic conductances shape picrotoxin-induced synchronized after-discharges in the guinea-pig hippocampal slice.
Topics: Animals; Computer Simulation; Culture Techniques; Electrophysiology; Epilepsy; Guinea Pigs; Hippocampus; Models, Neurological; Neurons; Picrotoxin; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 1993 |
Morphological and functional consequences of chronic epilepsy in rat hippocampal slice cultures.
Topics: Animals; Bicuculline; Chronic Disease; Culture Techniques; Disease Models, Animal; Electrophysiology; Epilepsy; Hippocampus; Neurons; Picrotoxin; Rats | 1993 |
Non-uniform propagation of epileptiform discharge in brain slices of rat neocortex.
Topics: Animals; Cerebral Cortex; Electric Stimulation; Electrodes; Epilepsy; Female; Guinea Pigs; In Vitro Techniques; Male; Neurons; Neurons, Afferent; Picrotoxin; Rats | 1993 |
Behavioural and electroencephalographic effects of Tityus serrulatus scorpion venom in rats.
Topics: Animals; Behavior, Animal; Convulsants; Dose-Response Relationship, Drug; Electrodes; Electroencephalography; Epilepsy; Hippocampus; Male; Microinjections; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Scorpion Venoms | 1993 |
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbital; Phenytoin; Picrotoxin; Rats; Rats, Wistar; Seizures | 1996 |
Inhibitory effect of NPY on the picrotoxin-induced activity in the hippocampus: a behavioural and electrophysiological study.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Electrophysiology; Epilepsy; Hippocampus; In Vitro Techniques; Injections; Male; Neuropeptide Y; Picrotoxin; Pyramidal Cells; Rats; Rats, Wistar | 1996 |
Propofol inhibits epileptiform activity in rat hippocampal slices.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Convulsants; Drug Evaluation, Preclinical; Epilepsy; GABA Antagonists; Hypnotics and Sedatives; In Vitro Techniques; Male; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley | 1996 |
Epileptic activity prevents synapse formation of hippocampal mossy fibers via L-type calcium channel activation in vitro.
Topics: Animals; Calcium Channels; Epilepsy; Hippocampus; In Vitro Techniques; Picrotoxin; Rats; Rats, Wistar; Synapses; Synaptic Transmission | 1997 |
Physiological and pharmacological alterations in postsynaptic GABA(A) receptor function in a hippocampal culture model of chronic spontaneous seizures.
Topics: Animals; Anticonvulsants; Cells, Cultured; Chloride Channels; Clonazepam; Disease Models, Animal; Epilepsy; GABA Agents; Hippocampus; Magnesium; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1997 |
Electrophysiological approach of the antiepileptic effect of dexamethasone on hippocampal slice culture using a multirecording system: the Physiocard.
Topics: Animals; Anticonvulsants; Convulsants; Dexamethasone; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy; GABA Antagonists; Hippocampus; In Vitro Techniques; Picrotoxin; Rats | 1997 |
Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro.
Topics: Animals; Cycloleucine; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Picrotoxin; Receptors, Metabotropic Glutamate | 1997 |
Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro.
Topics: Animals; Anticonvulsants; Electric Stimulation; Epilepsy; Hippocampus; Magnesium Deficiency; Male; Membrane Potentials; Neuropeptide Y; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y | 1997 |
Glutamate metabotropic receptors modulate the expression of in vitro epileptiform activity in rat hippocampal slices.
Topics: Animals; Epilepsy; Hippocampus; In Vitro Techniques; Male; Picrotoxin; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1997 |
Layer-specific pathways for the horizontal propagation of epileptiform discharges in neocortex.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy; GABA Antagonists; Membrane Potentials; Neocortex; Neural Pathways; Picrotoxin; Rats; Rats, Sprague-Dawley; Somatosensory Cortex | 1998 |
Endogenous serotonin inhibits epileptiform activity in rat hippocampal CA1 neurons via 5-hydroxytryptamine1A receptor activation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Barium; Epilepsy; Excitatory Postsynaptic Potentials; Fluoxetine; Hippocampus; In Vitro Techniques; Ketanserin; Male; Membrane Potentials; Metergoline; Neurons; Oxadiazoles; Picrotoxin; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptic Transmission; Tryptamines | 1998 |
Requirement of protein synthesis for group I mGluR-mediated induction of epileptiform discharges.
Topics: Action Potentials; Animals; Anisomycin; Brain Chemistry; Convulsants; Epilepsy; Excitatory Amino Acid Antagonists; Glycine; Guinea Pigs; Neurons; Periodicity; Picrotoxin; Protein Synthesis Inhibitors; Receptors, Metabotropic Glutamate; Resorcinols | 1998 |
[Changes in the blastogenic lymphocyte transformation during kindling induced by picrotoxin in rats].
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Delta Sleep-Inducing Peptide; Epilepsy; Kindling, Neurologic; Lipopolysaccharides; Lymphocyte Activation; Male; Phytohemagglutinins; Picrotoxin; Rats; Rats, Wistar | 1998 |
Abnormal targeting of developing hippocampal mossy fibers after epileptiform activities via L-type Ca2+ channel activation in vitro.
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Microscopy, Confocal; Mossy Fibers, Hippocampal; Picrotoxin; Rats; Rats, Wistar; Synaptic Transmission; Tetrodotoxin | 1999 |
Group I mGluR-mediated silent induction of long-lasting epileptiform discharges.
Topics: Animals; Epilepsy; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Guinea Pigs; In Vitro Techniques; Methoxyhydroxyphenylglycol; Picrotoxin; Receptors, Metabotropic Glutamate; Time Factors | 1999 |
Epileptiform propagation patterns mediated by NMDA and non-NMDA receptors in rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dose-Response Relationship, Drug; Epilepsy; Evoked Potentials; Magnesium; Neocortex; Neural Pathways; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex | 1999 |
The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam.
Topics: Amino Acid Sequence; Animals; Anti-Ulcer Agents; Anticonvulsants; Antitubercular Agents; Brain Chemistry; Diazepam; Drug Interactions; Drug Tolerance; Epilepsy; Isoniazid; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Peptide Fragments; Picrotoxin; Proteins; Receptors, GABA-A; Substance Withdrawal Syndrome | 1999 |
Long-lasting potentiation of epileptiform bursts by group I mGluRs is NMDA receptor independent.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Convulsants; Epilepsy; Excitatory Amino Acid Antagonists; Guinea Pigs; Hippocampus; Long-Term Potentiation; Methoxyhydroxyphenylglycol; Neurons; Periodicity; Picrotoxin; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2000 |
Guanosine and GMP prevent seizures induced by quinolinic acid in mice.
Topics: Animals; Anticonvulsants; Central Nervous System; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine; Guanosine Monophosphate; Male; Mice; Neurons; Picrotoxin; Quinolinic Acid; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Seizures; Time Factors | 2000 |
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
Topics: Animals; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; Microdialysis; Motor Activity; Neural Inhibition; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2001 |
Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices.
Topics: Animals; Calcium; Electric Stimulation; Electromagnetic Fields; Electrophysiology; Epilepsy; GABA Antagonists; Hippocampus; Image Processing, Computer-Assisted; Patch-Clamp Techniques; Picrotoxin; Potassium; Rats; Rats, Sprague-Dawley | 2001 |
Seizure-like activity in the disinhibited CA1 minislice of adult guinea-pigs.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Bicuculline; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; Guinea Pigs; Hippocampus; Neural Inhibition; Neurons, Afferent; Organ Culture Techniques; Picrotoxin; Pyridazines; Receptors, AMPA; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols | 2001 |
Developmental characteristics of epileptiform activity in immature rat neocortex: a comparison of four in vitro seizure models.
Topics: 4-Aminopyridine; Age Factors; Animals; Convulsants; Epilepsy; GABA Antagonists; Magnesium; Membrane Potentials; Neocortex; Organ Culture Techniques; Organophosphorus Compounds; Picrotoxin; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2001 |
DL-Tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.
Topics: Amygdala; Animals; Berberine Alkaloids; Dopamine; Dopamine Antagonists; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Hyperkinesis; Male; Motor Activity; Neural Inhibition; Neurons; Picrotoxin; Rats; Rats, Sprague-Dawley | 2001 |
Deterministic chaos and noise in three in vitro hippocampal models of epilepsy.
Topics: Animals; Bicuculline; Biomedical Engineering; Computer Simulation; Electrophysiology; Epilepsy; GABA Antagonists; Hippocampus; In Vitro Techniques; Magnesium; Male; Models, Neurological; Nonlinear Dynamics; Picrotoxin; Potassium; Rats; Rats, Sprague-Dawley; Stochastic Processes | 2001 |
Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam.
Topics: Ammonia; Animals; Arginine; Brain; Diazepam; Drug Interactions; Epilepsy; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hyperammonemia; Male; Neural Inhibition; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Synaptic Transmission | 2001 |
Sex difference in susceptibility to epileptic seizures in rats: importance of estrous cycle.
Topics: Animals; Disease Susceptibility; Epilepsy; Estrous Cycle; Female; GABA Antagonists; Injections, Intravenous; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Sex Factors | 2001 |
Differential roles for mGluR1 and mGluR5 in the persistent prolongation of epileptiform bursts.
Topics: Animals; Benzoates; Convulsants; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Picrotoxin; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Time Factors | 2002 |
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsy.
Topics: Acetylcholine; Action Potentials; Aggression; Animals; Behavior, Animal; Brain; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscarinic Agonists; Nerve Degeneration; Neural Pathways; Neurons; Picrotoxin; Pilocarpine; Rats; Rats, Wistar; Reaction Time; Statistics as Topic | 2002 |
Effects of clonazepam on picrotoxin-induced convulsions.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Epilepsy; Injections, Intraperitoneal; Picrotoxin; Rats; Rats, Wistar; Seizures | 1992 |
An experimental study of the effect of isoflurane on epileptiform bursts.
Topics: Animals; Electroencephalography; Epilepsy; Hippocampus; In Vitro Techniques; Isoflurane; Neurons, Afferent; Picrotoxin; Rats; Rats, Wistar | 1992 |
Calcium modulation of the N-methyl-D-aspartate (NMDA) response and electrographic seizures in immature hippocampus.
Topics: Age Factors; Animals; Calcium; Calcium Channels; Drug Interactions; Epilepsy; GABA Antagonists; Hippocampus; Ion Channel Gating; N-Methylaspartate; Penicillins; Picrotoxin; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1991 |
Initiation of epileptiform activity by excitatory amino acid receptors in the disinhibited rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cerebral Cortex; Electricity; Epilepsy; Female; Male; N-Methylaspartate; Picrotoxin; Quinoxalines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1991 |
Excitatory synaptic involvement in epileptiform bursting in the immature rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Cerebral Cortex; Epilepsy; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Neurons; Picrotoxin; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 1991 |
Regional and time dependent variations of low Mg2+ induced epileptiform activity in rat temporal cortex slices.
Topics: Animals; Baclofen; Brain Mapping; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Magnesium; Picrotoxin; Pyramidal Tracts; Rats; Seizures; Temporal Lobe | 1991 |
[Effects of activation and lesions of the superior colliculi of the lamina quadrigemina on epileptic activity in rats].
Topics: Animals; Bicuculline; Electrophysiology; Epilepsy; Kindling, Neurologic; Male; Penicillins; Picrotoxin; Rats; Rats, Inbred Strains; Superior Colliculi | 1991 |
[Anticonvulsive effects of neurotropin].
Topics: Animals; Anticonvulsants; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epilepsy; Mice; Picrotoxin; Polysaccharides; Rats; Rats, Inbred Strains | 1991 |
Epileptiform activity in the hippocampus produced by tetraethylammonium.
Topics: Animals; Electric Stimulation; Electrodes; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; Picrotoxin; Rats; Rats, Inbred Strains; Synapses; Tetraethylammonium; Tetraethylammonium Compounds | 1990 |
Anticonvulsant effects of tetronic acid derivatives on picrotoxin induced epileptiform activity in rat hippocampal slices.
Topics: Action Potentials; Animals; Anticonvulsants; Epilepsy; Female; Furans; Hippocampus; In Vitro Techniques; Picrotoxin; Rats; Rats, Inbred Strains | 1990 |
[Effects of destruction and activation of limbic structures on formation of convulsive and emotional disorders during picrotoxin kindling].
Topics: Amygdala; Animals; Behavior, Animal; Emotions; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Picrotoxin; Rats; Rats, Inbred Strains | 1990 |
Anticonvulsant effect of muscimol injected into the thalamus of spontaneously epileptic Mongolian gerbils.
Topics: Animals; Anticonvulsants; Baclofen; Dose-Response Relationship, Drug; Epilepsy; Female; Gerbillinae; Male; Muscimol; Picrotoxin; Receptors, GABA-A; Thalamic Nuclei | 1989 |
Involvement of non-NMDA receptors in picrotoxin-induced epileptiform activity in the hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Epilepsy; Hippocampus; In Vitro Techniques; Picrotoxin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Cholinergic modulation of epileptiform activity in the developing rat neocortex.
Topics: Action Potentials; Animals; Carbachol; Cerebral Cortex; Cholinergic Fibers; Electric Stimulation; Epilepsy; In Vitro Techniques; Picrotoxin; Rats | 1989 |
Neuronal activity in the subcortically denervated hippocampus: a chronic model for epilepsy.
Topics: Action Potentials; Animals; Epilepsy; Female; gamma-Aminobutyric Acid; Hippocampus; Picrotoxin; Rats; Rats, Inbred Strains | 1989 |
[Effect of brain extracts from rats subjected to korazol kindling on generalized epileptic activity].
Topics: Animals; Brain; Drug Interactions; Epilepsy; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Naloxone; Pentylenetetrazole; Peptides; Picrotoxin; Rats; Rats, Inbred Strains | 1989 |
Alterations in the microenvironment during spreading depression associated with epileptiform activity in the immature neocortex.
Topics: Aging; Animals; Calcium; Cerebral Cortex; Cortical Spreading Depression; Electric Stimulation; Epilepsy; In Vitro Techniques; Picrotoxin; Potassium; Rats | 1989 |
Evidence for the activation of the N-methyl-D-aspartate receptor during epileptiform discharge.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Epilepsy; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Neural Inhibition; Picrotoxin; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Synaptic Transmission; Valine | 1986 |
Epileptiform events induced by GABA-antagonists in entorhinal cortical cells in vitro are partly mediated by N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Bicuculline; Cerebral Cortex; Epilepsy; In Vitro Techniques; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
N-methylaspartate receptors mediate epileptiform activity evoked in some, but not all, conditions in rat neocortical slices.
Topics: Animals; Cerebral Cortex; Epilepsy; gamma-Aminobutyric Acid; Magnesium; Male; Membrane Potentials; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Recruitment, Neurophysiological; Synaptic Transmission | 1986 |
The initiation and spread of epileptiform bursts in the in vitro hippocampal slice.
Topics: Animals; Electrophysiology; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Neural Conduction; Neural Inhibition; Penicillins; Picrotoxin; Synapses; Synaptic Transmission | 1987 |
Suppression and induction of epileptic activity by neuronal grafts.
Topics: Animals; Denervation; Epilepsy; Hippocampus; Locus Coeruleus; Neurons; Picrotoxin; Rats; Reference Values; Seizures | 1988 |
GABAergic inhibition and epileptiform discharges in the turtle hippocampus in vitro.
Topics: Afferent Pathways; Animals; Bicuculline; Electric Stimulation; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons; Picrotoxin; Pipecolic Acids; Pyramidal Tracts; Reference Values; Synapses; Turtles | 1988 |
Extracellular K+ and Ca2+ changes during epileptiform discharges in the immature rat neocortex.
Topics: Animals; Calcium; Cerebral Cortex; Epilepsy; In Vitro Techniques; Kinetics; Microelectrodes; Picrotoxin; Potassium; Rats | 1987 |
Spontaneous ictal-like discharges and sustained potential shifts in the developing rat neocortex.
Topics: Aging; Animals; Cerebral Cortex; Electric Conductivity; Epilepsy; In Vitro Techniques; Membrane Potentials; Picrotoxin; Rats; Rats, Inbred Strains | 1987 |
Picrotoxin induced epileptiform activity in amygdaloid neurons.
Topics: Action Potentials; Amygdala; Animals; Epilepsy; In Vitro Techniques; Male; Neurilemma; Picrotoxin; Rats | 1987 |