picrotoxin and Disease Models, Animal

Topics: Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Apolipoprotein E4; Brain; Cognition Disorders; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; GABA Antagonists; Genetic Carrier Screening; Hippocampus; Humans; Mice; Mice, Transgenic; Nerve Net; Neural Inhibition; Picrotoxin; Synaptic Transmission; tau Proteins

Topics: Acoustic Stimulation; Animals; Attention Deficit Disorder with Hyperactivity; Cocculus; Disease Models, Animal; Double-Blind Method; Male; Movement Disorders; Nanoparticles; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Reaction Time; Reflex, Startle; Sleep Deprivation; Sleep, REM; Time Factors

Topics: Animals; Cocculus; Cytokines; Dengue Virus; Disease Models, Animal; Humans; Mice; Morphinans; Viremia

Topics: Animals; Anticonvulsants; Apoptosis; Brain; Cocculus; Disease Models, Animal; Female; Male; Neurons; Neuroprotective Agents; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Seizures; Strychnine

Topics: Animals; Cocculus; Disease Models, Animal; Ethanol; Kidney Function Tests; Male; Medicine, Ayurvedic; Nephrectomy; Plant Extracts; Plant Leaves; Protective Agents; Rats; Rats, Wistar; Renal Insufficiency, Chronic

Topics: Acids; Animals; Bicuculline; Caffeine; Cyclohexenes; Disease Models, Animal; Electroencephalography; Flavonoids; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Humulus; Hypnotics and Sedatives; Mice; Picrotoxin; Propiophenones; Receptors, GABA-A; Sleep; Sleep Initiation and Maintenance Disorders; Terpenes

Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy-Related Proteins; Brain Injuries, Traumatic; Disease Models, Animal; Epilepsy; Mice; Picrotoxin; Receptors, GABA-A; Seizures

Topics: Animals; Behavior, Animal; Disease Models, Animal; Light; Mice; Mice, Inbred C57BL; Neurons; Picrotoxin; Receptors, GABA-A; Retinal Cone Photoreceptor Cells; Retinal Degeneration; Retinal Ganglion Cells; Retinal Rod Photoreceptor Cells; Vision, Ocular

Topics: Adult; Animals; Cells, Cultured; Disease Models, Animal; GABAergic Neurons; Hippocampus; Humans; Intellectual Disability; Learning; Memory; Mice; Mutation; Neurodevelopmental Disorders; Organ Specificity; Picrotoxin; Proto-Oncogene Proteins p21(ras); Signal Transduction

Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mice; Pentylenetetrazole; Phytochemicals; Picrotoxin; Plant Bark; Plant Extracts; Plant Stems; Psychotria; Rats, Wistar; Seizures; Semicarbazides; Sleep; Sleep Latency; Strychnine; Water

Topics: Animals; Disease Models, Animal; Epileptic Syndromes; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; GABAergic Neurons; Long-Term Potentiation; Mice; Mice, Knockout; Neuronal Plasticity; Open Field Test; Perirhinal Cortex; Phosphinic Acids; Picrotoxin; Propanolamines; Protein Serine-Threonine Kinases; Receptors, GABA-B; Spasms, Infantile

Topics: Animals; Diazepam; Disease Models, Animal; Down Syndrome; Electrophysiological Phenomena; Female; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Picrotoxin; Seizures; Synaptic Transmission

Topics: Animals; Autism Spectrum Disorder; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Electroencephalography; Endocannabinoids; Excitatory Postsynaptic Potentials; GABA Antagonists; GABAergic Neurons; gamma-Aminobutyric Acid; Glutamic Acid; Long-Term Synaptic Depression; Male; Membrane Proteins; Mice; Mice, Transgenic; Neostriatum; Nerve Tissue Proteins; Patch-Clamp Techniques; Picrotoxin; Receptor, Cannabinoid, CB1

Topics: Animals; Cells, Cultured; Central Nervous System Stimulants; Convulsants; Disease Models, Animal; Disks Large Homolog 4 Protein; Dose-Response Relationship, Drug; Embryo, Mammalian; Epilepsy; Green Fluorescent Proteins; Hippocampus; Kindling, Neurologic; Male; Mice; Narcotic Antagonists; Narcotics; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Opioid, kappa; Repressor Proteins; Synapses; Synaptophysin; Tetrodotoxin; Transfection; Tumor Suppressor Proteins

Topics: Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Down Syndrome; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Humans; Long-Term Potentiation; Male; Memantine; Mice, Inbred C57BL; Mice, Transgenic; Picrotoxin; Prion Proteins

Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Electroencephalography; Fruit; GABA Antagonists; Gene Expression; Locomotion; Mice; Neurotransmitter Agents; Norepinephrine; Picrotoxin; Plant Extracts; RNA, Messenger; Serotonin; Tannins; Terminalia

Topics: Action Potentials; Animals; Autism Spectrum Disorder; Benzoxazines; Capillary Permeability; Central Nervous System Stimulants; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Exploratory Behavior; Gastrointestinal Microbiome; Humans; Interpersonal Relations; Limosilactobacillus reuteri; Male; Mice; Mice, Transgenic; Microfilament Proteins; Nerve Tissue Proteins; Picrotoxin; Piperidines; Receptors, Oxytocin; Smell; Social Behavior Disorders; Valproic Acid

Topics: Animals; Brain; Cells, Cultured; Convulsants; Cytokines; Disease Models, Animal; Gene Expression Regulation; Interleukin-10; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Nucleic Acids; Picrotoxin; RNA, Small Interfering; Seizures; Signal Transduction; STAT3 Transcription Factor

Topics: Animals; Anxiety; Blotting, Western; Disease Models, Animal; Epilepsy, Temporal Lobe; GABAergic Neurons; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Muscimol; Picrotoxin; Pilocarpine; Real-Time Polymerase Chain Reaction; Receptors, GABA-A

Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Cinnamates; Depsides; Disease Models, Animal; DNA Damage; Electron Transport Complex II; Hippocampus; Mice; Mitochondria; Neuroprotective Agents; Oxidative Stress; Picrotoxin; Rosmarinic Acid; Seizures

Topics: Air Pollutants, Occupational; Amygdala; Animals; Anxiety; Benzhydryl Compounds; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Evoked Potentials; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Enzymologic; Glutamate Decarboxylase; In Vitro Techniques; Indolizines; Male; Methionine; Neural Inhibition; Neurons; Phenols; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley

Topics: Animals; Central Nervous System Stimulants; Cognition Disorders; Disease Models, Animal; Excitatory Postsynaptic Potentials; Functional Laterality; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Infarction, Middle Cerebral Artery; Male; Maze Learning; Membrane Proteins; Motor Activity; Nerve Tissue Proteins; Picrotoxin; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Visual Perception

Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; gamma-Aminobutyric Acid; Hypericum; Male; Medicine, Traditional; Mice; Nitric Oxide; Pentylenetetrazole; Picrotoxin; Plant Extracts; Seizures; Time Factors

Topics: Age Factors; Animals; Anticonvulsants; Central Nervous System; Convulsants; Disease Models, Animal; Gait Disorders, Neurologic; Gene Expression Regulation; Infusions, Intraventricular; Lactic Acid; Locomotion; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Oligonucleotides, Antisense; Pentylenetetrazole; Picrotoxin; Seizures; tau Proteins

Topics: Animals; Benzoxazines; Chronic Disease; Disease Models, Animal; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neuronal Plasticity; Picrotoxin; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Psychological; Synaptic Transmission

Topics: Amygdala; Animals; Channelrhodopsins; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation; HEK293 Cells; Humans; Male; Neural Pathways; Nucleus Accumbens; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Self Administration; Spermine; Substance Withdrawal Syndrome; Synapses

Topics: Action Potentials; Animals; Anticonvulsants; Berberine Alkaloids; Carbamazepine; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Electrodes, Implanted; Finasteride; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Midazolam; Picrotoxin; Progesterone; Seizures

Topics: Animals; Animals, Newborn; Avoidance Learning; Cognition Disorders; Complement C3; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Net; Neurons; Picrotoxin; Synapses; Ultrasonography; Valine

Topics: Action Potentials; Aminopyridines; Analysis of Variance; Animals; Bacterial Proteins; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; GABA Agents; GABA Antagonists; Halorhodopsins; In Vitro Techniques; Kainic Acid; Luminescent Proteins; Membrane Potentials; Mice; Neurons; Optogenetics; Patch-Clamp Techniques; Picrotoxin; Status Epilepticus; Transduction, Genetic

Topics: Animals; Brain; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Dystonia; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation; In Vitro Techniques; Mice; Mice, Transgenic; Molecular Chaperones; Muscarinic Antagonists; Mutation; Neuronal Plasticity; Neurons; Picrotoxin; Pirenzepine; Synapses

Topics: Animals; Behavior, Animal; Disease Models, Animal; GABA-A Receptor Antagonists; Hippocampus; Male; Mental Retardation, X-Linked; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Picrotoxin

Topics: Animals; Attention Deficit Disorder with Hyperactivity; Choice Behavior; Disease Models, Animal; Dose-Response Relationship, Drug; Evoked Potentials, Visual; Exploratory Behavior; GABA Antagonists; GABA-A Receptor Agonists; Male; Muscimol; Neural Inhibition; Neurons; Picrotoxin; Prefrontal Cortex; Rats; Reaction Time; Reflex, Startle; Sensory Gating

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neuralgia; Phosphorylation; Picrotoxin; Receptors, AMPA; Sodium Channel Blockers; Subcellular Fractions; Synaptic Transmission; Tetrodotoxin

Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Central Nervous System Stimulants; Dendritic Spines; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neuronal Plasticity; Neurons; Picrotoxin; Presenilin-1; Synaptic Potentials; Time Factors

Topics: Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; Down-Regulation; Glycine; Hippocampus; Homer Scaffolding Proteins; Maze Learning; Mice; PC12 Cells; Pentylenetetrazole; Phenylacetates; Phosphorylation; Picrotoxin; Rats; Receptor, Metabotropic Glutamate 5; Ribosomal Protein S6 Kinases; RNA Interference; Seizures; Signal Transduction; TOR Serine-Threonine Kinases

Topics: Animals; Carotid Artery Diseases; Cells, Cultured; Central Nervous System Stimulants; Cyclin-Dependent Kinase 5; Disease Models, Animal; Embryo, Mammalian; Glucose; Hippocampus; Hypoxia; Long-Term Potentiation; Male; Mice; Neurons; Phosphorylation; Picrotoxin; Post-Synaptic Density; Rats; Receptors, N-Methyl-D-Aspartate; Serine

Topics: Animals; Central Nervous System Stimulants; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Freund's Adjuvant; HEK293 Cells; Humans; In Vitro Techniques; Inflammation; Male; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Microfilament Proteins; Nerve Tissue Proteins; Pain; Pain Measurement; Patch-Clamp Techniques; Picrotoxin; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord Dorsal Horn

Topics: Action Potentials; Animals; Animals, Newborn; Blindness; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; GABA Agents; GluK2 Kainate Receptor; HEK293 Cells; Hippocampus; Humans; Light; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phosphinic Acids; Picrotoxin; Pyridines; Receptors, AMPA; Receptors, Kainic Acid; Retinal Ganglion Cells; rho GTP-Binding Proteins; Rod Opsins; Sesterterpenes

Topics: Animals; Avoidance Learning; Cerebral Cortex; Corticosterone; Disease Models, Animal; Emotions; Environment; Housing, Animal; Hypothalamo-Hypophyseal System; Male; Memory; Motor Activity; Muscimol; Picrotoxin; Pituitary-Adrenal System; Rats, Wistar; Stress, Psychological

Topics: Action Potentials; Ammonia; Animals; Animals, Newborn; Arginase; Disease Models, Animal; Genetic Therapy; Hyperargininemia; In Vitro Techniques; Mice; Mice, Transgenic; Motor Cortex; Nerve Net; Neurons; Picrotoxin; Recovery of Function; Sodium Channel Blockers; Synapses; Tetrodotoxin

Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; Male; Maze Learning; Memory Disorders; Memory, Long-Term; Memory, Short-Term; Motor Activity; Pesticides; Picrotoxin; Pilot Projects; Pyrazoles; Random Allocation; Rats, Wistar; Receptors, GABA-A; Recognition, Psychology; Spatial Memory; Weight Gain

Topics: Animals; Benzylamines; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Ketamine; Memantine; Phosphinic Acids; Phosphorylation; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Swimming; Synaptic Transmission; Synaptosomes

Topics: Analysis of Variance; Animals; Axons; Calcium-Binding Proteins; Central Nervous System Stimulants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Freund's Adjuvant; Glial Fibrillary Acidic Protein; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Myelin-Oligodendrocyte Glycoprotein; Optic Nerve; Peptide Fragments; Picrotoxin; Protein Kinase C-alpha; Retina; Transcription Factor Brn-3A; Vimentin

Topics: Acetylcholine; Action Potentials; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Antagonists; Gene Expression Regulation; Hyperalgesia; Male; Pain Threshold; Picrotoxin; Prefrontal Cortex; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Sciatica; Subcellular Fractions; Synaptic Transmission; Valine

Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Cyclohexane Monoterpenes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Epilepsy; Flumazenil; GABA Modulators; In Vitro Techniques; Male; Mice; Monoterpenes; Pentylenetetrazole; Physical Stimulation; Picrotoxin; Rats; Rats, Wistar; Sciatic Nerve

Topics: Acute Disease; Animals; Animals, Newborn; Chickens; Disease Models, Animal; Glycine; Hypnotics and Sedatives; Male; Picrotoxin; Receptors, GABA-A; Receptors, Glycine; Serine; Stress, Psychological

Topics: Action Potentials; Analysis of Variance; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Epilepsy, Post-Traumatic; GABA Antagonists; In Vitro Techniques; Mice; Mossy Fibers, Hippocampal; Picrotoxin; Time Factors

Topics: Action Potentials; Amygdala; Animals; Disease Models, Animal; Electrophysiological Phenomena; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Male; Membrane Potentials; Neural Pathways; Picrotoxin; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Schizophrenia

Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Indoles; Mice; Mice, Inbred C57BL; Neocortex; Pentylenetetrazole; Picrotoxin; Potassium Channel Blockers; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Seizures; Time Factors

Topics: Analysis of Variance; Animals; Brain; Disease Models, Animal; Electroencephalography; Gene Expression; Male; Picrotoxin; Proto-Oncogene Proteins c-fos; Radiation Dosage; Radio Waves; Rats; Rats, Sprague-Dawley; Seizures

Topics: Animals; CD4-Positive T-Lymphocytes; Central Nervous System; Central Nervous System Stimulants; Dendritic Cells; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Flow Cytometry; Forkhead Transcription Factors; Freund's Adjuvant; Glycoproteins; Immune System Phenomena; Interferon-alpha; Interferon-gamma; Interleukin-7; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Picrotoxin; T-Lymphocytes; Time Factors

Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Semicarbazones; Structure-Activity Relationship; Strychnine; Toxicity Tests

Topics: Amygdala; Animals; Disease Models, Animal; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons; Neural Pathways; Neuronal Plasticity; Neurons; Picrotoxin; Rats; Receptors, GABA-A; Schizophrenia

Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Seeds; Seizures; Solanaceae

Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Capsaicin; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Epilepsy; GABA Antagonists; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Picrotoxin; Piperidines; Pyrazoles; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Dopamine D3; Serotonin; TRPV Cation Channels

Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Brain; Carbamazepine; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Entorhinal Cortex; Fructose; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Topiramate; Valproic Acid

Topics: Animals; Convulsants; Disease Models, Animal; Electrophoresis, Agar Gel; Enzyme Inhibitors; Finasteride; Indomethacin; Male; Mice; Neurons; Picrotoxin; Pregnanolone; Seizures

Topics: Animals; Anticonvulsants; Disease Models, Animal; Euphorbiaceae; Fatigue; Female; Male; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures; Stress, Psychological; Swimming

Topics: Animals; Biophysics; Conditioning, Classical; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Fear; GABA Antagonists; Hippocampus; In Vitro Techniques; Learning Disabilities; Lithium; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Picrotoxin; Pilocarpine; Status Epilepticus; Time Factors

Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; GABA Modulators; gamma-Aminobutyric Acid; Organoselenium Compounds; Phenobarbital; Picrotoxin; Rats; Seizures

Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Hexobarbital; Hypnotics and Sedatives; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Picrotoxin; Plant Extracts; Plant Roots; Securidaca; Seizures; Sleep; Strychnine; Time Factors

Topics: Animals; Behavior, Animal; Caffeine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Hydrocortisone; Locomotion; Male; Numerical Analysis, Computer-Assisted; Pentylenetetrazole; Phenotype; Picrotoxin; Reaction Time; Seizures; Statistics, Nonparametric; Zebrafish

Topics: Animals; Animals, Newborn; Antibodies; Bone Marrow; Cell Differentiation; Central Nervous System Stimulants; Cerebellum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Flow Cytometry; Freund's Adjuvant; Glycoproteins; In Vitro Techniques; Leukocyte Common Antigens; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Myelin Basic Protein; Myelin Proteolipid Protein; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Nerve Regeneration; Neurologic Examination; Oligodendroglia; Peptide Fragments; Picrotoxin; Proliferating Cell Nuclear Antigen; Receptors, Interleukin-8B; Recovery of Function; Severity of Illness Index; Stem Cells; Time Factors

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Animals, Newborn; Biophysics; Calcium; Calcium Channels; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Hippocampus; Hypothyroidism; In Vitro Techniques; Methimazole; Neurons; Patch-Clamp Techniques; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin

Topics: Animals; Behavior, Animal; Capsules; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Epilepsy; Hippocampus; Immunohistochemistry; Learning; Male; Memory; Neuroprotective Agents; Picrotoxin; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

Topics: Age Factors; Animals; Borates; Deafness; Disease Models, Animal; GABA Antagonists; Glycine; Homozygote; Mice; Mice, Mutant Strains; Picrotoxin; Receptors, Glycine; Synapses

Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Injuries; Calcium; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Extracellular Fluid; GABA Antagonists; Glucose; Hippocampus; Hydrogen-Ion Concentration; Hypoxia; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Membrane Potentials; Mice; Mice, Knockout; Mutation; Nerve Tissue Proteins; Neurons; Oligonucleotides; Patch-Clamp Techniques; Picrotoxin; Putrescine; Sodium Channels; Spermine; Tetrazolium Salts; Time Factors; Transfection; Valine

Topics: Animals; Biophysics; Calcium; Disease Models, Animal; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Glycine Agents; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Confocal; Patch-Clamp Techniques; Picrotoxin; Quinoxalines; Retina; Retinal Degeneration; Retinal Ganglion Cells; Sesterterpenes; Strychnine; Visual Pathways

Topics: Animals; Behavior, Animal; Biomarkers; Brain; Cell Phone; Disease Models, Animal; Electromagnetic Radiation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Neurotoxicity Syndromes; Picrotoxin; Proto-Oncogene Proteins c-fos; Radiation Injuries; Rats; Rats, Sprague-Dawley; Seizures; Time Factors

Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Convulsants; Disease Models, Animal; Doublecortin Domain Proteins; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Functional Laterality; Hippocampus; Kainic Acid; Luminescent Proteins; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Motor Activity; Neurogenesis; Neuropeptides; Patch-Clamp Techniques; Picrotoxin

Topics: Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; Animals, Genetically Modified; Behavior, Animal; Corpus Striatum; Discrimination, Psychological; Disease Models, Animal; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Antagonists; GABA Antagonists; Genotype; Huntingtin Protein; Huntington Disease; Inhibition, Psychological; Longitudinal Studies; Male; Nerve Tissue Proteins; Neural Pathways; Neuropsychological Tests; Nuclear Proteins; Picrotoxin; Prefrontal Cortex; Psychomotor Performance; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex, Startle; Synaptic Membranes; Trinucleotide Repeat Expansion

Topics: Animals; Animals, Newborn; Biophysics; Cerebral Cortex; Channelrhodopsins; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy, Absence; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Pathways; Neurons; Organophosphorus Compounds; Patch-Clamp Techniques; Picrotoxin; Receptors, AMPA; Thalamus

Topics: Animals; Disease Models, Animal; Electric Stimulation; Epilepsy; Evoked Potentials; GABA-A Receptor Antagonists; Hippocampus; Humans; Neurons; Picrotoxin; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Time Factors

Topics: Acanthaceae; Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Female; Male; Medicine, African Traditional; Methanol; Mice; Nigeria; Phenobarbital; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures; Solvents; Strychnine

Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Compounding; Drug Interactions; Epilepsy; Gas Chromatography-Mass Spectrometry; Lipid Peroxidation; Male; Manihot; Motor Activity; Muscarinic Agonists; Pentylenetetrazole; Phytotherapy; Picrotoxin; Pilocarpine; Plant Preparations; Random Allocation; Rats; Rats, Wistar; Seizures; Superoxide Dismutase

Topics: Actins; Aggression; Animals; Behavior, Animal; Bicuculline; Body Weight; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Dendritic Spines; Disease Models, Animal; Embryo, Mammalian; Endophenotypes; Exploratory Behavior; Female; GABA Antagonists; GABA-A Receptor Antagonists; Gene Expression Regulation; Genotype; Glial Fibrillary Acidic Protein; Glycine; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Inhibition, Psychological; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Membrane Potentials; Memory, Short-Term; Mental Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Muscle Strength; Mutation; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Picrotoxin; Post-Synaptic Density; Psychomotor Performance; Receptors, AMPA; Receptors, Kainic Acid; Recognition, Psychology; Rotarod Performance Test; Sialoglycoproteins; Statistics, Nonparametric; Time Factors

Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ethanol; Female; Galium; Male; Mice; Motor Activity; Neuroprotective Agents; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Reaction Time; Seizures; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors

Topics: Amygdala; Animals; Bipolar Disorder; Brain Mapping; CA2 Region, Hippocampal; Disease Models, Animal; Electrophysiology; Hippocampus; Interneurons; Kainic Acid; Male; Oscillometry; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Schizophrenia; Signal Transduction

Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Biophysics; Bromodeoxyuridine; Conditioning, Psychological; Disease Models, Animal; Doublecortin Domain Proteins; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fear; Feeding Behavior; GABA Antagonists; Green Fluorescent Proteins; Hippocampus; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Neurogenesis; Neuropeptides; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Picrotoxin; Protein Kinases; Sciatica; Signal Transduction

Topics: Animals; Anticonvulsants; Central Nervous System; Disease Models, Animal; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Epilepsy; Gene Expression Regulation, Developmental; In Situ Hybridization; Larva; Motor Activity; Muscles; Organ Specificity; Pentylenetetrazole; Picrotoxin; Small Molecule Libraries; Zebrafish

Topics: Age Factors; Age of Onset; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Diabetes Mellitus, Experimental; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Neural Pathways; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Receptors, Glutamate; Streptozocin; Synapses; Valine

Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Bicuculline; Convulsants; Dietary Fats; Disease Models, Animal; Electroencephalography; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Strychnine; Survival Rate; Time Factors

Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Kainic Acid; Lithium; Male; Muscarinic Agonists; Pentylenetetrazole; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Status Epilepticus

Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Electric Stimulation Therapy; Electroencephalography; Epilepsy, Absence; Fear; GABA Antagonists; GABA-A Receptor Antagonists; Genetic Predisposition to Disease; Male; Maze Learning; Microinjections; Neural Inhibition; Picrotoxin; Rats; Rats, Inbred Strains; Superior Colliculi; Treatment Outcome; Water Deprivation

Topics: Acoustic Stimulation; Age Factors; Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Auditory Threshold; Avian Proteins; Basigin; Blood Proteins; Carrier Proteins; Disease Models, Animal; Epilepsy, Reflex; Evoked Potentials, Auditory, Brain Stem; Gene Expression Regulation, Developmental; Genes, Recessive; Genetic Linkage; Genetic Predisposition to Disease; Genotype; Hearing Tests; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Knockout; Mice, Mutant Strains; Microsatellite Repeats; N-Methylaspartate; Physical Chromosome Mapping; Picrotoxin; Vesicular Transport Proteins

Topics: Animals; Disease Models, Animal; Epilepsy; Female; Injections, Intraperitoneal; Kindling, Neurologic; Male; Picrotoxin; Random Allocation; Rats; Rats, Sprague-Dawley

Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Apomorphine; Avoidance Learning; Biguanides; Brain Chemistry; Chlordiazepoxide; Clonidine; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Droperidol; Drug Interactions; GABA Agents; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Male; Memantine; Mephenytoin; Microinjections; Pentylenetetrazole; Phentolamine; Picrotoxin; Piperazines; Propranolol; Pyrimidines; Rats; Serotonin; Sulpiride; Ventromedial Hypothalamic Nucleus; Yohimbine

Topics: Animals; Atropine; Carbachol; Cholinergic Agonists; Disease Models, Animal; Drug Interactions; Electric Stimulation; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Antagonists; Hippocampus; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Picrotoxin; Receptors, Cholinergic; Receptors, GABA-A; RNA-Binding Proteins; Time Factors

Topics: Animals; Atropine; Basal Ganglia; Basal Ganglia Diseases; Bicuculline; Brain Stem; Cats; Choline O-Acetyltransferase; Disease Models, Animal; Efferent Pathways; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Excitatory Amino Acid Agonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; Locomotion; Muscarinic Antagonists; Muscimol; Muscle Tonus; N-Methylaspartate; Neural Inhibition; Picrotoxin; Stimulation, Chemical

Topics: Analysis of Variance; Animals; Anxiety; Autoradiography; Behavior, Animal; Binding Sites; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Exploratory Behavior; Factor Analysis, Statistical; Fear; GABA Agonists; GABA Antagonists; GABA Modulators; Male; Midazolam; Muscimol; Picrotoxin; Rats; Rats, Wistar; Time Factors; Tritium

Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Carrier Proteins; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; Genetic Predisposition to Disease; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Seizures

Topics: Amygdala; Animals; Biogenic Monoamines; Disease Models, Animal; Fluorescence Resonance Energy Transfer; Gene Expression Profiling; Gene Expression Regulation; GTP-Binding Proteins; Hippocampus; Injections; Male; Oligonucleotide Array Sequence Analysis; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neurotransmitter; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schizophrenia

Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Epilepsy; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Glutamic Acid; Guanosine; In Vitro Techniques; Injections, Intraventricular; Male; Neurons; Phenobarbital; Picrotoxin; Quinolinic Acid; Rats; Rats, Wistar

Topics: 2-Amino-5-phosphonovalerate; Animals; Cognition Disorders; Crosses, Genetic; Dentate Gyrus; Disease Models, Animal; Down Syndrome; Evoked Potentials; Female; GABA-A Receptor Antagonists; Gene Dosage; Glycine; Hippocampus; Long-Term Potentiation; Magnesium; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Patch-Clamp Techniques; Picrotoxin; Presynaptic Terminals; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Species Specificity; Trisomy

Topics: Ambrosia; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Electroshock; Epilepsy; Exploratory Behavior; Isoniazid; Male; Mice; Motor Activity; Penicillins; Phytotherapy; Picrotoxin; Plant Preparations; Psychomotor Performance; Rats; Reaction Time; Time Factors; Tubocurarine

Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hyperoxia; Hypoglossal Nerve; Hypoxia; Male; Motor Activity; Oxygen; Phrenic Nerve; Picrotoxin; Rats; Respiration

Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Excitatory Amino Acid Agonists; Extracellular Fluid; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Intralaminar Thalamic Nuclei; Kainic Acid; Male; Microdialysis; Microinjections; Neural Pathways; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Superior Colliculi

Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Fluoxetine; Hindlimb; Male; Mice; Mice, Inbred CBA; Picrotoxin; Seizures; Stress, Psychological; Swimming

Topics: Animals; Brain; Cell Death; Cell Respiration; Convulsants; Cytochromes; Disease Models, Animal; Electron Transport Chain Complex Proteins; Energy Metabolism; Epilepsy; Intracellular Membranes; Male; Membrane Fluidity; Membrane Lipids; Membrane Potentials; Mitochondria; Mitochondrial Proton-Translocating ATPases; Nerve Degeneration; Oxidative Phosphorylation; Picrotoxin; Rats

Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dopamine Agents; Electric Stimulation; Electromagnetic Fields; Epilepsy; Exploratory Behavior; Feeding Behavior; Female; Kindling, Neurologic; Levodopa; Male; Picrotoxin; Rats; Rats, Wistar; Seizures; Sexual Behavior, Animal

Topics: Animals; Disease Models, Animal; Down Syndrome; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Long-Term Potentiation; Male; Mice; Organ Culture Techniques; Picrotoxin; Synaptic Transmission

Topics: Animals; Annona; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; GABA Agonists; GABA Antagonists; Hexanes; Male; Mice; Muscimol; Picrotoxin; Plant Extracts; Plant Leaves; Receptors, GABA-A

Topics: Animals; Apnea; Bicuculline; Blood Pressure; Cats; Disease Models, Animal; GABA Antagonists; GABA-A Receptor Antagonists; Inhalation; Injections, Intravenous; Ketamine; Phrenic Nerve; Picrotoxin; Receptors, GABA-A; Respiratory Mechanics

Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug Interactions; Epilepsy; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Neural Inhibition; Neuronal Plasticity; Neurons; Nipecotic Acids; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tetrodotoxin

Topics: Animals; Brain; Cholesterol; Disease Models, Animal; Male; Membranes; Microsomes; Phospholipids; Picrotoxin; Rats; Seizures

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amygdala; Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Matched-Pair Analysis; Nerve Net; Neural Inhibition; Neurons; Parahippocampal Gyrus; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Age Factors; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy, Absence; Evoked Potentials; Excitatory Postsynaptic Potentials; Homeostasis; Lidocaine; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Picrotoxin; Pyramidal Cells; Somatosensory Cortex; Synaptic Transmission; Thalamic Nuclei; Valine

Topics: Animals; Bicuculline; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Muscimol; Picrotoxin; Seizures

Topics: Action Potentials; Acyclic Monoterpenes; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Mice; Monoterpenes; Neural Conduction; Pentylenetetrazole; Picrotoxin; Reaction Time; Seizures; Time Factors

Topics: Action Potentials; Acute Disease; Animals; Brain; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Female; Injections, Intraventricular; Male; Picrotoxin; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Status Epilepticus

Topics: Alismataceae; Animals; Central Nervous System; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Electroshock; Epilepsy; Isoniazid; Male; Mice; Mice, Inbred Strains; Muscle Hypotonia; Penicillins; Phytotherapy; Picrotoxin; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Stereotyped Behavior

Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Lethal Dose 50; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Persea; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures

Topics: Administration, Oral; Animals; Anticonvulsants; Behavior, Animal; Dibenzazepines; Disease Models, Animal; Electroencephalography; Hippocampus; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures

Topics: Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Cell Survival; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila; Drug Evaluation, Preclinical; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; Larva; Pentylenetetrazole; Phenotype; Phenytoin; Picrotoxin; Seizures

Topics: Analgesics; Animals; Anticonvulsants; Benzhydryl Compounds; Benzyl Compounds; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hot Temperature; Male; Mice; Molecular Structure; Motor Activity; Pain Measurement; Pain Threshold; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Receptors, Purinergic P1; Seizures; Structure-Activity Relationship; Urea

Topics: Animals; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Down Syndrome; Electric Stimulation; Excitatory Postsynaptic Potentials; Exploratory Behavior; Female; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurons; Pentylenetetrazole; Picrotoxin

Topics: Animals; Disease Models, Animal; GABA Antagonists; Hippocampus; Neurons; Picrotoxin; Rats; Rats, Sprague-Dawley; Schizophrenia

Topics: Age Factors; Aminophylline; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Disease Susceptibility; Drug Interactions; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Seizures; Severity of Illness Index

Topics: Animals; Central Nervous System Stimulants; Chromosomes, Human, Pair 21; Cyclopentanes; Disease Models, Animal; Down Syndrome; Furans; GABA Antagonists; Ginkgolides; Humans; Maze Learning; Memory; Mice; Mice, Transgenic; Neuropsychological Tests; Pentylenetetrazole; Picrotoxin

Topics: Amygdala; Animals; Convulsants; Disease Models, Animal; Environment; Exploratory Behavior; Hippocampus; Male; Neural Pathways; Neurons; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Schizophrenia; Space Perception

Topics: Analysis of Variance; Animals; Anticonvulsants; Chromatography, Thin Layer; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glycine; Mice; Mice, Inbred BALB C; Phytotherapy; Picrotoxin; Plant Preparations; Seizures; Vicia faba

Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, Liquid; Disease Models, Animal; Dopamine; Electroencephalography; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Methoxyhydroxyphenylglycol; Microdialysis; Picrotoxin; Pilocarpine; Rats; Rats, Wistar; Seizures; Serotonin; Statistics, Nonparametric; Time Factors

Topics: Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Mice; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures

Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Epilepsy; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Mice, Inbred CBA; Motor Activity; Pentylenetetrazole; Picrotoxin; Pyridines; Zolpidem

Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Cestrum; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Exploratory Behavior; Hyperalgesia; Isoniazid; Male; Mice; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Stereotyped Behavior

Topics: Alcohol Drinking; Alcoholism; Animals; Arecoline; Atropine; Central Nervous System Stimulants; Cyproheptadine; Disease Models, Animal; Drinking Behavior; Food Preferences; Haloperidol; Humans; Isoproterenol; Male; Methamphetamine; Mice; Phenoxybenzamine; Picrotoxin; Propranolol

Topics: Animals; Bicuculline; Blood Pressure; Brain; Cats; Disease Models, Animal; gamma-Aminobutyric Acid; Guinea Pigs; Hypertension; Medulla Oblongata; Pentobarbital; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Respiration

Topics: 4-Aminobutyrate Transaminase; Administration, Topical; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diffusion; Disease Models, Animal; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Huntington Disease; Injections; Male; Picrotoxin; Rats; Transaminases

Topics: Animals; Behavior, Animal; Benzodiazepinones; Catatonia; Convulsants; Disease Models, Animal; Electroshock; Epilepsy, Tonic-Clonic; Female; Humans; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Seizures

Topics: Animals; Basal Ganglia Diseases; Disease Models, Animal; Female; Movement Disorders; Papio; Picrotoxin; Reaction Time

Topics: Animals; Antioxidants; Bemegride; Brain Chemistry; Chorea; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Epilepsy; Female; GABA Agonists; Haloperidol; Hyperkinesis; Lipid Peroxidation; Male; Mice; Picrotoxin; Rats; Syndrome

Topics: Animals; Behavior, Animal; Disease Models, Animal; GABA-A Receptor Antagonists; Male; Microinjections; Pain; Picrotoxin; Rats; Rats, Sprague-Dawley; Thalamic Nuclei

Topics: Administration, Oral; Animals; Anticonvulsants; Bemegride; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Electroshock; Female; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Seizures

Topics: Analgesics; Anesthesia, Intravenous; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Male; Pain; Pentobarbital; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Time Factors

Topics: Animals; Bicuculline; Chronic Disease; Culture Techniques; Disease Models, Animal; Electrophysiology; Epilepsy; Hippocampus; Neurons; Picrotoxin; Rats

Topics: Animals; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy, Generalized; Frontal Lobe; GABA Antagonists; Male; Mathematics; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Thalamus; Time Factors

Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbital; Phenytoin; Picrotoxin; Rats; Rats, Wistar; Seizures

Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Animals; Azides; Benzodiazepines; Carbolines; Catecholamines; Corticosterone; Diazepam; Disease Models, Animal; Female; GABA-A Receptor Agonists; Glucocorticoids; Immunity, Cellular; Immunity, Innate; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mifepristone; Nadolol; Naltrexone; Neurosecretory Systems; Oxidopamine; Phentolamine; Picrotoxin; Propranolol; Receptors, GABA-A; Spleen; Sympathetic Nervous System

Topics: Animals; Anticonvulsants; Cells, Cultured; Chloride Channels; Clonazepam; Disease Models, Animal; Epilepsy; GABA Agents; Hippocampus; Magnesium; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

Topics: Animals; Antipsychotic Agents; Disease Models, Animal; GABA Antagonists; GABA-A Receptor Antagonists; Haloperidol; Male; Picrotoxin; Prefrontal Cortex; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia

Topics: Amygdala; Animals; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Haloperidol; Male; Neural Inhibition; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia

Topics: Animals; Caffeine; Convulsants; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Kindling, Neurologic; Male; Morphine; Morphine Dependence; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA; Receptors, Purinergic P1; Seizures

Topics: Amygdala; Animals; Dentate Gyrus; Disease Models, Animal; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; Isoenzymes; Male; Neural Pathways; Neurons; Picrotoxin; Postmortem Changes; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Schizophrenia

Topics: Adrenergic Agents; Animals; Anxiety; Apomorphine; Avoidance Learning; Disease Models, Animal; Dopamine; Dopamine Agents; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus, Middle; Male; Memantine; Microinjections; Neurotransmitter Agents; Phenylephrine; Picrotoxin; Rats; Serotonin; Sulpiride; Yohimbine

Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Drug Combinations; Drug Tolerance; Male; Mice; Midazolam; Muscle, Skeletal; Picrotoxin; Pregnanolone; Receptors, GABA-A; Seizures

Topics: Acetylcholine; Action Potentials; Aggression; Animals; Behavior, Animal; Brain; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscarinic Agonists; Nerve Degeneration; Neural Pathways; Neurons; Picrotoxin; Pilocarpine; Rats; Rats, Wistar; Reaction Time; Statistics as Topic

Topics: Animals; Cerebral Cortex; Cobalt; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Estrogens, Conjugated (USP); Fluoroacetates; Male; Methionine Sulfoximine; Pentylenetetrazole; Picrotoxin; Rats; Seizures

Topics: Animals; Behavior; Caudate Nucleus; Diazepam; Disease Models, Animal; gamma-Aminobutyric Acid; Haloperidol; Humans; Lithium; Penicillins; Picrotoxin; Rats; Schizophrenia; Stereotyped Behavior; Syndrome; Tetanus Toxin

Topics: Animals; Anticonvulsants; Baclofen; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electrophysiology; Epilepsy, Absence; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred Strains; Organophosphorus Compounds; Picrotoxin; Quinoxalines; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate

Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chi-Square Distribution; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrocardiography; Female; Incidence; Male; Naloxone; Picrotoxin; Rats; Rats, Inbred Strains

Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Epilepsy, Absence; GABA Antagonists; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Seizures; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

Topics: Adenosine; Aminophylline; Amygdala; Animals; Bicuculline; Carbolines; Cerebral Cortex; Disease Models, Animal; Electrodes, Implanted; Epilepsies, Partial; GABA Antagonists; Harmine; Kindling, Neurologic; Male; Picrotoxin; Rats

Topics: Animals; Anticonvulsants; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epilepsy; Mice; Picrotoxin; Polysaccharides; Rats; Rats, Inbred Strains

Topics: Animals; Cats; Caudate Nucleus; Disease Models, Animal; Dyskinesia, Drug-Induced; Facial Muscles; gamma-Aminobutyric Acid; Globus Pallidus; Male; Neural Pathways; Picrotoxin; Receptors, GABA-A; Tongue

Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Imipramine; Male; Muscimol; Norepinephrine; Penbutolol; Picrotoxin; Prazosin; Rats; Rats, Inbred Strains

Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrocardiography; Electroencephalography; Picrotoxin; Rabbits; Respiration; Seizures

Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Catecholamines; Cats; Caudate Nucleus; Chlorpromazine; Cholinesterase Inhibitors; Chromatography, Thin Layer; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Electric Stimulation; Ganglionic Blockers; Movement Disorders; Phenylacetates; Picrotoxin; Rats; Tranquilizing Agents; Tritium; Tubocurarine; Tyrosine