Compounds > picropodophyllin
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picropodophyllin and Malignant Melanoma

picropodophyllin has been researched along with Malignant Melanoma in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (88.89)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
All-Ericsson, C; Andersson, S; Axelson, M; Economou, MA; Girnita, A; Girnita, L; Larsson, O; Menu, E; Seregard, S; Vasilcanu, D2
All-Ericsson, C; Aström, K; Axelson, M; Economou, MA; Girnita, A; Girnita, L; Larsson, O; Seregard, S2
Economou, MA1
Hei, TK; Ivanov, VN; Karasic, TB1
Axelson, M; Girnita, A; Girnita, L; Larsson, O; Vasilcanu, D; Vasilcanu, R1
Axelson, M; Girnita, A; Girnita, L; Sehat, B; Vasilcanu, D; Vasilcanu, R; Yin, S1

Other Studies

9 other study(ies) available for picropodophyllin and Malignant Melanoma

ArticleYear
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
    Investigative ophthalmology & visual science, 2008, Volume: 49, Issue:6

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Proliferation; Cell Survival; Humans; Melanoma; Mice; Mice, SCID; Neoplasm Transplantation; Podophyllotoxin; Receptor, IGF Type 1; Specific Pathogen-Free Organisms; Transplantation, Heterologous; Tumor Cells, Cultured; Uveal Neoplasms; Vascular Endothelial Growth Factor A

2008
Introduction: Uveal melanoma.
    Acta ophthalmologica, 2008, Volume: 86 Thesis 4

    Topics: Administration, Oral; Animals; Humans; Melanoma; Neoplasm Metastasis; Podophyllotoxin; Prognosis; Proto-Oncogene Proteins c-met; Receptor, IGF Type 1; Uveal Neoplasms; Vascular Endothelial Growth Factor A

2008
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
    Acta ophthalmologica, 2008, Volume: 86 Thesis 4

    Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Extracellular Matrix Proteins; Humans; Matrix Metalloproteinase Inhibitors; Melanoma; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Phosphorylation; Podophyllotoxin; Receptor, IGF Type 1; Transplantation, Heterologous; Uveal Neoplasms

2008
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
    Acta ophthalmologica, 2008, Volume: 86 Thesis 4

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Melanoma; Mice; Mice, SCID; Neoplasm Transplantation; Podophyllotoxin; Receptor, IGF Type 1; Transplantation, Heterologous; Uveal Neoplasms; Vascular Endothelial Growth Factor A

2008
Uveal melanoma and macular degeneration: molecular biology and potential therapeutic applications.
    Acta ophthalmologica, 2008, Volume: 86, Issue:8

    Topics: Animals; Biomarkers; Humans; Macular Degeneration; Melanoma; Mice; Molecular Biology; Podophyllotoxin; Prognosis; Receptor, IGF Type 1; Signal Transduction; Uveal Neoplasms; Vascular Endothelial Growth Factor A

2008
Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma.
    Experimental cell research, 2010, Jul-15, Volume: 316, Issue:12

    Topics: Apoptosis; Cell Survival; Humans; Melanoma; Podophyllotoxin; Receptor, IGF Type 1; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured

2010
The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway.
    Oncogene, 2004, Oct-14, Volume: 23, Issue:47

    Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Line; Cell Line, Tumor; Cell Survival; Fibroblasts; Humans; Insulin Receptor Substrate Proteins; Kinetics; Melanoma; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Podophyllotoxin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Recombinant Proteins; Transfection

2004
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Feb-15, Volume: 12, Issue:4

    Topics: Animals; Blotting, Western; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, SCID; Neoplasm Invasiveness; Phosphorylation; Podophyllotoxin; Receptor, IGF Type 1; Uveal Neoplasms; Xenograft Model Antitumor Assays

2006
Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin.
    Molecular pharmacology, 2008, Volume: 73, Issue:3

    Topics: Cell Survival; Enzyme Activation; Enzyme Induction; Glioblastoma; Humans; Melanoma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; RNA, Small Interfering; Signal Transduction; Transfection; Tumor Cells, Cultured; Ubiquitination

2008