picropodophyllin and Disease Models, Animal

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: Animals; Antigens, CD34; Apoptosis; Disease Models, Animal; Fetal Blood; Fusion Proteins, bcr-abl; Humans; In Vitro Techniques; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Transgenic; Microtubules; Neoplastic Stem Cells; Phosphorylation; Podophyllotoxin; Signal Transduction; Stem Cells; Transcriptional Activation; Tumor Suppressor Protein p53

Topics: Animals; Apoptosis; Cell Cycle; Cell Hypoxia; Cell Proliferation; Cell Survival; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Hypoxia-Ischemia, Brain; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Neural Stem Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Podophyllotoxin; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction

Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Disease Models, Animal; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression; Humans; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Ligands; Male; Mice; Podophyllotoxin; Receptor, IGF Type 1; Receptor, Insulin; Rhabdomyosarcoma; Signal Transduction; Xenograft Model Antitumor Assays

Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred NOD; Myelin Sheath; Neural Conduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Podophyllotoxin; Recombinant Proteins; Sciatic Nerve

Topics: Animals; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Female; Growth Substances; Hyperinsulinism; Insulin; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Molecular Targeted Therapy; Peptides; Podophyllotoxin; Receptor, IGF Type 1; Therapies, Investigational

Topics: Animals; Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Humans; Mice; Mutation; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Tumor Burden; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Humans; Lung Neoplasms; Mice; Podophyllotoxin; Receptor, IGF Type 1

Topics: Administration, Oral; Animals; Blotting, Western; Cell Culture Techniques; Choroid; Choroidal Neovascularization; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Injections, Intraperitoneal; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C57BL; Pigment Epithelium of Eye; Podophyllotoxin; Receptor, IGF Type 1; Transfection; Vascular Endothelial Growth Factor A

Topics: Animals; Breast Neoplasms; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Mice; Mice, Transgenic; Models, Biological; Podophyllotoxin; ras Proteins; Receptor, IGF Type 1; Signal Transduction

Topics: Animals; Caspase 3; Cell Proliferation; Cerebellar Neoplasms; Disease Models, Animal; Gene Knockdown Techniques; Humans; Medulloblastoma; Mice; Podophyllotoxin; Receptor, IGF Type 1

Topics: Adrenergic beta-Antagonists; Angiogenesis Inhibitors; Animals; Animals, Newborn; Blood-Retinal Barrier; Blotting, Western; Capillary Permeability; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Humans; Infant, Newborn; Injections, Intraperitoneal; Injections, Subcutaneous; Insulin-Like Growth Factor I; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; Oxygen; Podophyllotoxin; Propranolol; Receptor, IGF Type 1; Receptors, Adrenergic, beta; Retinal Neovascularization; Retinopathy of Prematurity; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A

Topics: Animals; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Hyperalgesia; Insulin-Like Growth Factor I; Male; Oncogene Protein v-akt; Pain Measurement; Pain Threshold; Podophyllotoxin; Postoperative Complications; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, IGF Type 1; Skin

Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Fluorodeoxyglucose F18; Mice; Podophyllotoxin; Positron-Emission Tomography; Receptor, IGF Type 1; Rhabdomyosarcoma

Topics: Animals; Bone Marrow; Cell Proliferation; Disease Models, Animal; Enzyme Activation; In Vitro Techniques; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Microcirculation; Mitogen-Activated Protein Kinase 1; Multiple Myeloma; Neovascularization, Pathologic; Paraproteins; Phosphorylation; Podophyllotoxin; Receptor, IGF Type 1; Survival Rate; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Bone Neoplasms; Disease Models, Animal; Kaplan-Meier Estimate; Mice; Multiple Myeloma; Neovascularization, Pathologic; Podophyllotoxin; Receptor, IGF Type 1

Topics: Animals; Apoptosis; Cardiovascular Agents; Carotid Artery Injuries; Catheterization; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperplasia; Insulin-Like Growth Factor I; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Signal Transduction; Time Factors; Tunica Intima