picolinic acid has been researched along with Seizures in 5 studies
picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206
picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Picolinic acid completely prevented seizures." | 5.27 | Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acids. ( Lapin, IP, 1983) |
| "Picolinic acid (PIC) is an endogenous metabolite of the kynurenine pathway and a chelating agent added to dietary supplements." | 1.46 | Influence of picolinic acid on seizure susceptibility in mice. ( Cioczek-Czuczwar, A; Czuczwar, P; Parada-Turska, J; Turski, WA, 2017) |
| "Picolinic acid completely prevented seizures." | 1.27 | Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acids. ( Lapin, IP, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cioczek-Czuczwar, A | 1 |
| Czuczwar, P | 1 |
| Turski, WA | 1 |
| Parada-Turska, J | 1 |
| Paruszewski, R | 1 |
| Strupińska, M | 1 |
| Rostafińska-Suchar, G | 1 |
| Stables, JP | 1 |
| Lapin, IP | 1 |
| Tonohiro, T | 1 |
| Kaneko, T | 1 |
| Tanabe, M | 1 |
| Iwata, N | 1 |
| Kockler, DR | 1 |
| McCarthy, MW | 1 |
| Lawson, CL | 1 |
5 other studies available for picolinic acid and Seizures
| Article | Year |
|---|---|
Influence of picolinic acid on seizure susceptibility in mice.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Male; Mice; Pi | 2017 |
New derivatives of picolinic acid and nicotinic acid with anticonvulsant activity.
Topics: Animals; Anticonvulsants; Computers; Drug Design; Electric Stimulation; Mice; Picolinic Acids; Seizu | 2005 |
Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acids.
Topics: Animals; Dose-Response Relationship, Drug; Female; Kynurenic Acid; Kynurenine; Male; Muridae; Picoli | 1983 |
Picolinic acid and indole-2-carboxylic acid: two types of glycinergic compounds modulate motor function differentially.
Topics: Animals; Anticonvulsants; Bicuculline; Carboxylic Acids; Cats; Decerebrate State; Female; Glycine Ag | 1997 |
Seizure activity and unresponsiveness after hydroxycut ingestion.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Citrates; Drug Combinations; Drugs, Chinese Herb | 2001 |