picolinic acid has been researched along with Koch's Disease in 3 studies
picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206
picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen because of its sterilizing activity against non-replicating Mycobacterium tuberculosis (Mtb), but its mechanism of action has remained enigmatic." | 1.72 | Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents. ( Aldrich, CC; Aragaw, WW; Cole, MS; Dick, T; Grüber, G; Harikishore, A; Hegde, PV; Jachak, G; Ragunathan, P; Sharma, S, 2022) |
| "We found that Mycobacterium tuberculosis infection induced marked upregulation of IDO-1 expression in both human and murine macrophages in vitro and in the lungs of mice following aerosol challenge with M." | 1.38 | M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. ( Blumenthal, A; Britton, WJ; Ehrt, S; Guillemin, GJ; Huch, JH; Nagalingam, G; Saunders, BM; Smythe, GA; Walker, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hegde, PV | 1 |
| Aragaw, WW | 1 |
| Cole, MS | 1 |
| Jachak, G | 1 |
| Ragunathan, P | 1 |
| Sharma, S | 1 |
| Harikishore, A | 1 |
| Grüber, G | 1 |
| Dick, T | 1 |
| Aldrich, CC | 1 |
| Pavan, FR | 1 |
| Poelhsitz, GV | 1 |
| Barbosa, MI | 1 |
| Leite, SR | 1 |
| Batista, AA | 1 |
| Ellena, J | 1 |
| Sato, LS | 1 |
| Franzblau, SG | 1 |
| Moreno, V | 1 |
| Gambino, D | 1 |
| Leite, CQ | 1 |
| Blumenthal, A | 1 |
| Nagalingam, G | 1 |
| Huch, JH | 1 |
| Walker, L | 1 |
| Guillemin, GJ | 1 |
| Smythe, GA | 1 |
| Ehrt, S | 1 |
| Britton, WJ | 1 |
| Saunders, BM | 1 |
3 other studies available for picolinic acid and Koch's Disease
| Article | Year |
|---|---|
Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
Topics: Amidohydrolases; Antitubercular Agents; Carboxylic Acids; Drug Resistance, Bacterial; Humans; Microb | 2022 |
Ruthenium(II) phosphine/diimine/picolinate complexes: inorganic compounds as agents against tuberculosis.
Topics: Animals; Antitubercular Agents; Cell Line; Crystallography, X-Ray; Humans; Imines; Mice; Models, Mol | 2011 |
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
Topics: Animals; Blotting, Western; DNA Primers; Female; Gene Expression Profiling; Humans; Immunohistochemi | 2012 |