picolinic acid has been researched along with Granulocytic Leukemia, Chronic in 1 studies
picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206
picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In human chronic myelogenous leukemia cells, K562, which are relatively resistant to various inducers of apoptosis, the apoptosis was induced by picolinic acid and dipicolinic acid in about 50% of the cells 5-10 mM via the caspase pathway, but was not at 1 mM." | 1.31 | Apoptosis induced by niacin-related compounds in K562 cells but not in normal human lymphocytes. ( Fujita, H; Ogata, S; Okumura, K; Shibata, K; Taguchi, H; Takeuchi, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ogata, S | 1 |
| Takeuchi, M | 1 |
| Fujita, H | 1 |
| Shibata, K | 1 |
| Okumura, K | 1 |
| Taguchi, H | 1 |
1 other study available for picolinic acid and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Apoptosis induced by niacin-related compounds in K562 cells but not in normal human lymphocytes.
Topics: Antineoplastic Agents; Apoptosis; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positi | 2000 |