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picolinic acid and Diabetes Mellitus, Adult-Onset

picolinic acid has been researched along with Diabetes Mellitus, Adult-Onset in 36 studies

picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206
picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.

Research Excerpts

ExcerptRelevanceReference
"Insulin sensitivity was negatively correlated to soleus and tibialis muscle intramyocellular lipids and intrahepatic lipid content."2.75Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus. ( Anderson, RA; Cefalu, WT; Levitan, L; Martin, CK; Martin, JM; Newcomer, B; Pinsonat, P; Qin, J; Rood, J; Sereda, O; Wang, ZQ; Zhang, XH, 2010)
"Chromium treatment has been reported to improve glycemic control and insulin sensitivity in specific populations of patients with type 2 diabetes."2.72Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. ( Bakker, SJ; Bilo, HJ; Gans, RO; Groenier, KH; Houweling, ST; Jansman, FG; Kleefstra, N; Meyboom-de Jong, B, 2006)
"Thirty-seven subjects with type 2 diabetes were evaluated."2.72Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. ( Cefalu, WT; Martin, J; Matthews, DE; Volaufova, J; Wachtel, D; Wang, ZQ; Zhang, XH, 2006)
"The prevalence of the type 2 diabetes mellitus is still growing."2.71[Chromium (III)-ion enhances the utilization of glucose in type-2 diabetes mellitus]. ( Keszthelyi, Z; Koltai, K; Mózsik, G; Past, T; Szabó, L, 2003)
"Of 60 patients with type 2 diabetes mellitus, 30 were randomly assigned to group A, and 30 to group B."2.71Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus. ( Anderson, RA; Briski, A; Kocijancic, A; Radovancevic, B; Vrtovec, B; Vrtovec, M, 2005)
"Chromium is an essential nutrient involved in normal carbohydrate and lipid metabolism."2.68Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. ( Anderson, RA; Bryden, NA; Cheng, N; Chi, J; Feng, J; Polansky, MM, 1997)
"Chromium (Cr) is a trace element involved in glucose homeostasis."2.52Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. ( Phung, OJ; Yin, RV, 2015)
"Hallmark features of type 2 diabetes mellitus include glucosuria and polyuria."1.38Renal distal tubule proliferation and increased aquaporin 2 level but decreased urine osmolality in db/db mouse: treatment with chromium picolinate. ( Abdelsayed, R; Baban, B; Liu, JY; Mozaffari, MS; Zakhary, I, 2012)
" The highest variability of DNA-damage was monitored under the prolonged treatment with high dosage of CrPic."1.38Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics. ( Golubnitschaja, O; Schild, HH; Yeghiazaryan, K, 2012)
"To evaluate whether CrPic may aid in treatment of the insulin resistance syndrome, we assessed its effects in JCR:LA-corpulent rats, a model of this syndrome."1.31Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats. ( Baldor, LC; Cefalu, WT; Russell, JC; Wang, ZQ; Zhang, XH, 2002)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (13.89)18.2507
2000's20 (55.56)29.6817
2010's11 (30.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huang, S1
Peng, W1
Jiang, X1
Shao, K1
Xia, L1
Tang, Y1
Qiu, J1
Yin, RV1
Phung, OJ1
Paiva, AN1
Lima, JG1
Medeiros, AC1
Figueiredo, HA1
Andrade, RL1
Ururahy, MA1
Rezende, AA1
Brandão-Neto, J1
Almeida, Md1
Zhou, J1
Xu, H1
Huang, K1
Abdourahman, A1
Edwards, JG1
Wang, YQ1
Dong, Y1
Yao, MH1
Cefalu, WT3
Rood, J1
Pinsonat, P1
Qin, J1
Sereda, O1
Levitan, L1
Anderson, RA3
Zhang, XH3
Martin, JM1
Martin, CK1
Wang, ZQ3
Newcomer, B1
Lodyga-Chruscinska, E1
Micera, G1
Garribba, E1
Mozaffari, MS3
Baban, B2
Abdelsayed, R2
Liu, JY2
Wimborne, H1
Rodriguez, N1
Abebe, W1
Zakhary, I1
Sahin, K1
Tuzcu, M1
Orhan, C1
Gencoglu, H1
Ulas, M1
Atalay, M1
Sahin, N1
Hayirli, A1
Komorowski, JR2
Shao, C1
Lü, XF1
Xiao, XH1
Xu, ZR1
Yang, ZJ1
Wang, P1
Liu, XL1
Yang, WY1
Yeghiazaryan, K1
Schild, HH1
Golubnitschaja, O1
Kalman, DS1
Brown, M1
Keszthelyi, Z1
Past, T1
Koltai, K1
Szabó, L1
Mózsik, G1
Vincent, JB1
Kojima, Y1
Yoshikawa, Y1
Ueda, E1
Kondo, M1
Takahashi, S1
Matsukura, T1
Sakurai, H1
Hiroi, T1
Imaoka, S1
Funae, Y1
Ravina, A1
Vrtovec, M1
Vrtovec, B1
Briski, A1
Kocijancic, A1
Radovancevic, B1
Mita, Y1
Ishihara, K1
Fukuchi, Y1
Fukuya, Y1
Yasumoto, K1
Fuhr, JP1
He, H1
Goldfarb, N1
Nash, DB1
Patel, C1
Ballas, C1
Schaffer, SW1
Kleefstra, N1
Houweling, ST1
Jansman, FG1
Groenier, KH1
Gans, RO1
Meyboom-de Jong, B1
Bakker, SJ1
Bilo, HJ1
Martin, J1
Wachtel, D1
Volaufova, J1
Matthews, DE1
Trumbo, PR1
Ellwood, KC1
Singer, GM1
Geohas, J2
Daly, A1
Juturu, V1
Finch, M1
Vinson, JA1
Jain, SK1
Rains, JL1
Croad, JL1
Lee, NA1
Reasner, CA1
Grant, KE1
Chandler, RM1
Castle, AL1
Ivy, JL1
Cheng, N2
Bryden, NA1
Polansky, MM1
Chi, J1
Feng, J1
McCarty, MF1
Baldor, LC1
Russell, JC1
Evans, GW1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Combination of Zinc, Chromium, Vitamin C, and Copper Supplement for Prediabetes Progression: Randomized Controlled-Trial in Jakarta[NCT04511468]670 participants (Anticipated)Interventional2021-06-23Recruiting
Chromium and Insulin Action[NCT00398853]Phase 4100 participants (Actual)Interventional2003-10-31Completed
Effect of Chromium Supplementation on Insulin Sensitivity in Patients With Type 2 Diabetes[NCT01368328]Phase 357 participants (Anticipated)Interventional2010-03-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for picolinic acid and Diabetes Mellitus, Adult-Onset

ArticleYear
Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus.
    Nutrition journal, 2015, Feb-13, Volume: 14

    Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Chlorides; Chromium; Chromium Compounds; Diabetes Mel

2015
Organoselenium Small Molecules and Chromium(III) Complexes for Intervention in Chronic Low-grade Inflammation and Type 2 Diabetes.
    Current topics in medicinal chemistry, 2016, Volume: 16, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Azoles; Chromium Compounds; Cysteine; Diabetes Mellitus, Ty

2016
Recent advances in the nutritional biochemistry of trivalent chromium.
    The Proceedings of the Nutrition Society, 2004, Volume: 63, Issue:1

    Topics: Animals; Blood Glucose; Carrier Proteins; Chromium; Diabetes Mellitus, Type 2; Diet; Dietary Supplem

2004
Chromium picolinate intake and risk of type 2 diabetes: an evidence-based review by the United States Food and Drug Administration.
    Nutrition reviews, 2006, Volume: 64, Issue:8

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Evidence-Based Medicine; Food Labelin

2006

Trials

11 trials available for picolinic acid and Diabetes Mellitus, Adult-Onset

ArticleYear
Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2015, Volume: 32

    Topics: Administration, Oral; Case-Control Studies; Diabetes Mellitus, Type 2; Dietary Supplements; Female;

2015
Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus.
    Metabolism: clinical and experimental, 2010, Volume: 59, Issue:5

    Topics: Adult; Aged; Blood Glucose; Body Composition; Body Weight; Cohort Studies; Diabetes Mellitus, Type 2

2010
[Efficacy of tianmaixiaoke tablets in the treatment of newly diagnosed type 2 diabetes mellitus in China].
    Zhonghua yi xue za zhi, 2012, Jun-12, Volume: 92, Issue:22

    Topics: Adult; Aged; Aged, 80 and over; China; Chromium; Diabetes Mellitus, Type 2; Female; Glycated Hemoglo

2012
[Chromium (III)-ion enhances the utilization of glucose in type-2 diabetes mellitus].
    Orvosi hetilap, 2003, Oct-19, Volume: 144, Issue:42

    Topics: Adult; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Female; Glucose; Glycated Hemoglobin;

2003
Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus.
    American heart journal, 2005, Volume: 149, Issue:4

    Topics: Chromium; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; E

2005
Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial.
    Diabetes care, 2006, Volume: 29, Issue:3

    Topics: Aged; Blood Pressure; Body Mass Index; Chromium; Diabetes Mellitus, Type 2; Double-Blind Method; Fem

2006
Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes.
    Diabetes care, 2006, Volume: 29, Issue:8

    Topics: Adipose Tissue; Adult; Aged; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; I

2006
The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial.
    Diabetes technology & therapeutics, 2006, Volume: 8, Issue:6

    Topics: Adult; Biotin; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Combinations; Fem

2006
Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial.
    The American journal of the medical sciences, 2007, Volume: 333, Issue:3

    Topics: Adult; Biotin; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Chromium; Diabetes Melli

2007
Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM.
    Diabetes care, 1994, Volume: 17, Issue:12

    Topics: Administration, Oral; Adult; Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Die

1994
Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes.
    Diabetes, 1997, Volume: 46, Issue:11

    Topics: Adult; Aged; Blood Glucose; Chromium; Diabetes Mellitus, Type 2; Fasting; Female; Glycated Hemoglobi

1997

Other Studies

21 other studies available for picolinic acid and Diabetes Mellitus, Adult-Onset

ArticleYear
The effect of chromium picolinate supplementation on the pancreas and macroangiopathy in type II diabetes mellitus rats.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Adiponectin; Animals; Apelin; Cerebrovascular Disorders; Colorimetry; Diabetes Complications; Diabet

2014
Chromium supplementation improves glucose tolerance in diabetic Goto-Kakizaki rats.
    IUBMB life, 2008, Volume: 60, Issue:8

    Topics: Analysis of Variance; Animals; Diabetes Mellitus, Type 2; Dietary Supplements; Dose-Response Relatio

2008
Chromium picolinate inhibits resistin secretion in insulin-resistant 3T3-L1 adipocytes via activation of amp-activated protein kinase.
    Clinical and experimental pharmacology & physiology, 2009, Volume: 36, Issue:8

    Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Ty

2009
Complex formation in aqueous solution and in the solid state of the potent insulin-enhancing V(IV)O2+ compounds formed by picolinate and quinolinate derivatives.
    Inorganic chemistry, 2011, Feb-07, Volume: 50, Issue:3

    Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Models, Molecular; Oxides; Picolini

2011
Renal and glycemic effects of high-dose chromium picolinate in db/db mice: assessment of DNA damage.
    The Journal of nutritional biochemistry, 2012, Volume: 23, Issue:8

    Topics: Albuminuria; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; DNA Breaks,

2012
Renal distal tubule proliferation and increased aquaporin 2 level but decreased urine osmolality in db/db mouse: treatment with chromium picolinate.
    Experimental and molecular pathology, 2012, Volume: 92, Issue:1

    Topics: Animals; Aquaporin 2; Biological Transport; Blood Glucose; Body Weight; Cell Proliferation; Dehydrat

2012
The effects of chromium picolinate and chromium histidinate administration on NF-κB and Nrf2/HO-1 pathway in the brain of diabetic rats.
    Biological trace element research, 2012, Volume: 150, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Chelating Agents; Chromium; Diabetes Mellit

2012
Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics.
    Infectious disorders drug targets, 2012, Volume: 12, Issue:5

    Topics: Animals; Comet Assay; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; DNA Breaks; DNA Da

2012
Chromium picolinate and type 2 diabetes.
    The American journal of clinical nutrition, 2003, Volume: 78, Issue:1

    Topics: Diabetes Mellitus, Type 2; Humans; Picolinic Acids

2003
Harnessing chromium in the fight against diabetes.
    Drug discovery today, 2003, Nov-01, Volume: 8, Issue:21

    Topics: Chromium; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Insulin;

2003
Blood glucose lowering and toxicological effects of zinc (II) complexes with maltol, threonine, and picolinic acid.
    Research communications in molecular pathology and pharmacology, 2002, Volume: 112, Issue:1-4

    Topics: Animals; Blood Glucose; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2E1; Diabete

2002
Initiating insulin in type 2 diabetes.
    The Israel Medical Association journal : IMAJ, 2004, Volume: 6, Issue:12

    Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Picolinic Acids

2004
Supplementation with chromium picolinate recovers renal Cr concentration and improves carbohydrate metabolism and renal function in type 2 diabetic mice.
    Biological trace element research, 2005,Summer, Volume: 105, Issue:1-3

    Topics: Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism; Chromium; Creatinine; Diabetes Mellitu

2005
Use of chromium picolinate and biotin in the management of type 2 diabetes: an economic analysis.
    Disease management : DM, 2005, Volume: 8, Issue:4

    Topics: Biotin; Cost Savings; Diabetes Mellitus, Type 2; Drug Combinations; Glycated Hemoglobin; Health Care

2005
Effects of chronic chromium picolinate treatment in uninephrectomized rat.
    Metabolism: clinical and experimental, 2005, Volume: 54, Issue:9

    Topics: Animals; Body Weight; Diabetes Mellitus, Type 2; Glucose Intolerance; Insulin; Iron Chelating Agents

2005
So many choices, so what's a consumer to do?: A commentary on "Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-alpha, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of strepto
    Free radical biology & medicine, 2007, Oct-15, Volume: 43, Issue:8

    Topics: Animals; C-Reactive Protein; Cholesterol; Chromium; Diabetes Mellitus, Experimental; Diabetes Mellit

2007
Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-alpha, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocin-treated diabetic rats.
    Free radical biology & medicine, 2007, Oct-15, Volume: 43, Issue:8

    Topics: Animals; C-Reactive Protein; Cholesterol; Chromium; Diabetes Mellitus, Experimental; Diabetes Mellit

2007
Chromium and exercise training: effect on obese women.
    Medicine and science in sports and exercise, 1997, Volume: 29, Issue:8

    Topics: Adolescent; Adult; Blood Glucose; Coronary Disease; Diabetes Mellitus, Type 2; Exercise Therapy; Fem

1997
High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes.
    Medical hypotheses, 1999, Volume: 52, Issue:5

    Topics: Biotin; Diabetes Mellitus, Type 2; Drug Synergism; Enzyme Induction; Gene Expression Regulation, Enz

1999
Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats.
    The Journal of nutrition, 2002, Volume: 132, Issue:6

    Topics: Administration, Oral; Animals; Area Under Curve; Blood Glucose; Carbohydrate Metabolism; Diabetes Me

2002
An inexpensive, convenient adjunct for the treatment of diabetes.
    The Western journal of medicine, 1991, Volume: 155, Issue:5

    Topics: Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Female; Humans; Male; Picolinic Acids

1991