Page last updated: 2024-10-20

picolinic acid and Depression

picolinic acid has been researched along with Depression in 4 studies

picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206
picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"St."2.40The effects of nutritional supplements on the treatment of depression, diabetes, and hypercholesterolemia in the renal patient. ( Duncan, MG, 1999)
"Depression is often associated with insulin resistance, owing to cortisol overproduction; conversely, many studies suggest that diabetics are at increased risk for depression."1.29Enhancing central and peripheral insulin activity as a strategy for the treatment of endogenous depression--an adjuvant role for chromium picolinate? ( McCarty, MF, 1994)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dubey, VK1
Ansari, F1
Vohora, D1
Khanam, R1
Krikorian, R1
Eliassen, JC1
Boespflug, EL1
Nash, TA1
Shidler, MD1
McCarty, MF1
Duncan, MG1

Reviews

1 review available for picolinic acid and Depression

ArticleYear
The effects of nutritional supplements on the treatment of depression, diabetes, and hypercholesterolemia in the renal patient.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 1999, Volume: 9, Issue:2

    Topics: Depression; Diabetic Nephropathies; Dietary Supplements; Ericales; Garlic; Humans; Hypercholesterole

1999

Trials

1 trial available for picolinic acid and Depression

ArticleYear
Improved cognitive-cerebral function in older adults with chromium supplementation.
    Nutritional neuroscience, 2010, Volume: 13, Issue:3

    Topics: Aged; Blood Glucose; Brain; Chromium; Cognition; Dementia; Depression; Dietary Supplements; Double-B

2010

Other Studies

2 other studies available for picolinic acid and Depression

ArticleYear
Possible involvement of corticosterone and serotonin in antidepressant and antianxiety effects of chromium picolinate in chronic unpredictable mild stress induced depression and anxiety in rats.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2015, Volume: 29

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain; Chronic Disease; Corticosterone

2015
Enhancing central and peripheral insulin activity as a strategy for the treatment of endogenous depression--an adjuvant role for chromium picolinate?
    Medical hypotheses, 1994, Volume: 43, Issue:4

    Topics: Brain; Chemotherapy, Adjuvant; Depression; Humans; Insulin; Picolinic Acids; Receptor, Insulin

1994