picolinic acid has been researched along with Compensatory Hyperinsulinemia in 6 studies
picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206
picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.
Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mechanistically, Cr3+ reversed hyperinsulinemia-induced cellular cholesterol accrual and associated defects in cholesterol transporter ATP-binding cassette transporter-A1 trafficking and apolipoprotein A1-mediated cholesterol efflux." | 1.37 | Evidence that chromium modulates cellular cholesterol homeostasis and ABCA1 functionality impaired by hyperinsulinemia--brief report. ( Elmendorf, JS; Penque, BA; Sealls, W, 2011) |
| "To evaluate whether CrPic may aid in treatment of the insulin resistance syndrome, we assessed its effects in JCR:LA-corpulent rats, a model of this syndrome." | 1.31 | Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats. ( Baldor, LC; Cefalu, WT; Russell, JC; Wang, ZQ; Zhang, XH, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elseweidy, MM | 1 |
| Amin, RS | 1 |
| Atteia, HH | 1 |
| Aly, MA | 1 |
| Hoffman, NJ | 1 |
| Penque, BA | 2 |
| Habegger, KM | 1 |
| Sealls, W | 2 |
| Tackett, L | 2 |
| Elmendorf, JS | 3 |
| Lydic, ML | 1 |
| McNurlan, M | 1 |
| Bembo, S | 1 |
| Mitchell, L | 1 |
| Komaroff, E | 1 |
| Gelato, M | 1 |
| Horvath, EM | 1 |
| McCarthy, AM | 1 |
| Raman, P | 1 |
| Brozinick, JT | 1 |
| Cefalu, WT | 1 |
| Wang, ZQ | 1 |
| Zhang, XH | 1 |
| Baldor, LC | 1 |
| Russell, JC | 1 |
1 trial available for picolinic acid and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome.
Topics: Adult; Female; Humans; Hyperinsulinism; Insulin Resistance; Iron Chelating Agents; Obesity; Picolini | 2006 |
5 other studies available for picolinic acid and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Nigella sativa Oil and Chromium Picolinate Ameliorate Fructose-Induced Hyperinsulinemia by Enhancing Insulin Signaling and Suppressing Insulin-Degrading Enzyme in Male Rats.
Topics: Animals; Fructose; Hyperinsulinism; Insulin; Insulysin; Male; Nigella sativa; Picolinic Acids; Plant | 2018 |
Chromium enhances insulin responsiveness via AMPK.
Topics: Actins; AMP-Activated Protein Kinases; Animals; Cell Membrane; Cells, Cultured; Cholesterol; Chromiu | 2014 |
Evidence that chromium modulates cellular cholesterol homeostasis and ABCA1 functionality impaired by hyperinsulinemia--brief report.
Topics: Adipocytes; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apolipoprotein A-I; | 2011 |
Antidiabetogenic effects of chromium mitigate hyperinsulinemia-induced cellular insulin resistance via correction of plasma membrane cholesterol imbalance.
Topics: Animals; Cell Membrane; Cholesterol; Cytoskeleton; Female; Glucose; Glucose Transporter Type 4; Hype | 2008 |
Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats.
Topics: Administration, Oral; Animals; Area Under Curve; Blood Glucose; Carbohydrate Metabolism; Diabetes Me | 2002 |