picolinic acid has been researched along with Cerebral Malaria in 4 studies
picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206
picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miu, J | 1 |
| Ball, HJ | 1 |
| Mellor, AL | 1 |
| Hunt, NH | 3 |
| Medana, IM | 2 |
| Day, NP | 2 |
| Salahifar-Sabet, H | 1 |
| Stocker, R | 2 |
| Smythe, G | 2 |
| Bwanaisa, L | 1 |
| Njobvu, A | 1 |
| Kayira, K | 1 |
| Turner, GD | 2 |
| Taylor, TE | 1 |
| Clark, CJ | 1 |
| Mackay, GM | 1 |
| Smythe, GA | 1 |
| Bustamante, S | 1 |
| Stone, TW | 1 |
| Phillips, RS | 1 |
| Hien, TT | 1 |
| Phu, NH | 1 |
| Mai, NT | 1 |
| Chu'ong, LV | 1 |
| Chau, TT | 1 |
| Taylor, A | 1 |
| Salahifar, H | 1 |
| Farrar, J | 1 |
| White, NJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819] | 256 participants (Anticipated) | Observational | 2021-01-02 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for picolinic acid and Cerebral Malaria
| Article | Year |
|---|---|
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.
Topics: Adult; Child; Child, Preschool; Disease Progression; Humans; Kynurenine; Malaria, Cerebral; Malawi; | 2003 |
The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Artemether; Artemisinins; Humans; Kynurenine; Lacta | 2002 |
2 other studies available for picolinic acid and Cerebral Malaria
| Article | Year |
|---|---|
Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria.
Topics: Animals; Brain; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Indoleamine | 2009 |
Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition.
Topics: Animals; Chemokine CCL4; Disease Models, Animal; Kynurenine; Kynurenine 3-Monooxygenase; Macrophage | 2005 |