picolinic acid has been researched along with Amyotrophic Lateral Sclerosis in 1 studies
picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206
picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The kynurenine pathway (KP), activated during neuroinflammation, is emerging as a possible contributory factor in ALS." | 7.76 | The kynurenine pathway and inflammation in amyotrophic lateral sclerosis. ( Brew, BJ; Chen, Y; Coggan, S; Cullen, KM; Garner, B; Grant, R; Guillemin, GJ; Meininger, V; Stankovic, R, 2010) |
| " The kynurenine pathway (KP), activated during neuroinflammation, is emerging as a possible contributory factor in ALS." | 3.76 | The kynurenine pathway and inflammation in amyotrophic lateral sclerosis. ( Brew, BJ; Chen, Y; Coggan, S; Cullen, KM; Garner, B; Grant, R; Guillemin, GJ; Meininger, V; Stankovic, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Stankovic, R | 1 |
| Cullen, KM | 1 |
| Meininger, V | 1 |
| Garner, B | 1 |
| Coggan, S | 1 |
| Grant, R | 1 |
| Brew, BJ | 1 |
| Guillemin, GJ | 1 |
1 other study available for picolinic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Brain; Female; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2, | 2010 |