picolinic acid has been researched along with Alloxan Diabetes in 23 studies
picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206
picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The results showed that no pathological, toxic feces and urine changes were observed in clinical signs of parental and fetal rats in chromium malate groups." | 1.42 | Evaluation of the Reproductive Toxicity, Glycometabolism, Glycometabolism-Related Enzyme Levels and Lipid Metabolism of Chromium Malate Supplementation in Sprague-Dawley Rats. ( Bao, Y; Feng, W; Huang, J; Mao, G; Wang, W; Wu, X; Yang, L; Zhang, W; Zhao, T; Zhou, Z, 2015) |
| " The highest variability of DNA-damage was monitored under the prolonged treatment with high dosage of CrPic." | 1.38 | Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics. ( Golubnitschaja, O; Schild, HH; Yeghiazaryan, K, 2012) |
| "Treatment with chromium picolinate produced a significant decrease in elevated cholesterol and triglyceride levels in both types of diabetic rats." | 1.32 | Insulin sensitising action of chromium picolinate in various experimental models of diabetes mellitus. ( Dhalla, NS; Goyal, RK; Sharma, G; Shindea, UA; Xu, YJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (56.52) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, H | 1 |
| Hu, Y | 1 |
| Shao, M | 1 |
| Chen, S | 1 |
| Qi, S | 1 |
| Qi, SS | 1 |
| Zheng, HX | 1 |
| Jiang, H | 1 |
| Yuan, LP | 1 |
| Dong, LC | 1 |
| Fan, W | 1 |
| Chen, K | 1 |
| Zheng, G | 1 |
| Wang, W | 2 |
| Teng, A | 1 |
| Liu, A | 1 |
| Ming, D | 1 |
| Yan, P | 1 |
| Huang, S | 1 |
| Peng, W | 1 |
| Jiang, X | 1 |
| Shao, K | 1 |
| Xia, L | 1 |
| Tang, Y | 1 |
| Qiu, J | 1 |
| Feng, W | 1 |
| Zhang, W | 1 |
| Zhao, T | 1 |
| Mao, G | 1 |
| Wu, X | 2 |
| Zhou, Z | 1 |
| Huang, J | 1 |
| Bao, Y | 1 |
| Yang, L | 1 |
| Sasaki, N | 1 |
| Egashira, Y | 1 |
| Sanada, H | 1 |
| Refaie, FM | 1 |
| Esmat, AY | 1 |
| Mohamed, AF | 1 |
| Aboul Nour, WH | 1 |
| Komorowski, JR | 3 |
| Tuzcu, M | 3 |
| Sahin, N | 2 |
| Juturu, V | 3 |
| Orhan, C | 2 |
| Ulas, M | 1 |
| Sahin, K | 3 |
| Sundaram, B | 2 |
| Singhal, K | 1 |
| Sandhir, R | 2 |
| Yeghiazaryan, K | 1 |
| Schild, HH | 1 |
| Golubnitschaja, O | 1 |
| Aggarwal, A | 1 |
| Kucuk, O | 1 |
| Ozercan, IH | 2 |
| Yasui, H | 1 |
| Tamura, A | 1 |
| Takino, T | 1 |
| Sakurai, H | 2 |
| Kim, DS | 1 |
| Kim, TW | 1 |
| Kang, JS | 1 |
| Shindea, UA | 1 |
| Sharma, G | 1 |
| Xu, YJ | 1 |
| Dhalla, NS | 1 |
| Goyal, RK | 1 |
| Mita, Y | 1 |
| Ishihara, K | 1 |
| Fukuchi, Y | 1 |
| Fukuya, Y | 1 |
| Yasumoto, K | 1 |
| Khanam, R | 2 |
| Pillai, KK | 2 |
| Machaliński, B | 1 |
| Walczak, M | 1 |
| Syrenicz, A | 1 |
| Machalińska, A | 1 |
| Grymuła, K | 1 |
| Stecewicz, I | 1 |
| Wiszniewska, B | 1 |
| Dabkowska, E | 1 |
| Yasumatsu, N | 1 |
| Yoshikawa, Y | 1 |
| Adachi, Y | 1 |
| Onderci, M | 1 |
| Ustundag, B | 1 |
| Cikim, G | 1 |
| Sriramoju, V | 1 |
| Vinson, JA | 1 |
| Jain, SK | 1 |
| Rains, JL | 1 |
| Croad, JL | 1 |
23 other studies available for picolinic acid and Alloxan Diabetes
| Article | Year |
|---|---|
Chromium Picolinate Protects against Testicular Damage in STZ-Induced Diabetic Rats via Anti-Inflammation, Anti-Oxidation, Inhibiting Apoptosis, and Regulating the TGF-β1/Smad Pathway.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Nephropathie | 2023 |
Protective Effects of Chromium Picolinate Against Diabetic-Induced Renal Dysfunction and Renal Fibrosis in Streptozotocin-Induced Diabetic Rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Gene Express | 2020 |
Role of liver fatty acid binding protein in hepatocellular injury: effect of CrPic treatment.
Topics: Alanine Transaminase; Alloxan; Animals; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, E | 2013 |
The effect of chromium picolinate supplementation on the pancreas and macroangiopathy in type II diabetes mellitus rats.
Topics: Adiponectin; Animals; Apelin; Cerebrovascular Disorders; Colorimetry; Diabetes Complications; Diabet | 2014 |
Evaluation of the Reproductive Toxicity, Glycometabolism, Glycometabolism-Related Enzyme Levels and Lipid Metabolism of Chromium Malate Supplementation in Sprague-Dawley Rats.
Topics: Animals; Chromium Compounds; Diabetes Mellitus, Experimental; Dietary Supplements; Dose-Response Rel | 2015 |
Production of L-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Carboxy-Lyases; Diabetes Mellitus, Experimental; Hepatocytes; Kynurenine; Ma | 2009 |
Effect of chromium supplementation on the diabetes induced-oxidative stress in liver and brain of adult rats.
Topics: Alloxan; Animals; Brain; Catalase; Chromium; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dis | 2009 |
Chromium picolinate modulates serotonergic properties and carbohydrate metabolism in a rat model of diabetes.
Topics: Animals; Body Weight; Brain; Carbohydrate Metabolism; Chromium; Diabetes Mellitus, Experimental; Die | 2012 |
Anti-atherogenic effect of chromium picolinate in streptozotocin-induced experimental diabetes.
Topics: Animals; Atherosclerosis; Cholesterol; Diabetes Mellitus, Experimental; Glucosephosphate Dehydrogena | 2013 |
Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics.
Topics: Animals; Comet Assay; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; DNA Breaks; DNA Da | 2012 |
Chromium picolinate attenuates hyperglycemia-induced oxidative stress in streptozotocin-induced diabetic rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Diabetes Mellitus, Experiment | 2013 |
Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin.
Topics: Adipose Tissue; Animals; Biotin; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Die | 2013 |
Structure-dependent metallokinetics of antidiabetic vanadyl-picolinate complexes in rats: studies on solution structure, insulinomimetic activity, and metallokinetics.
Topics: Adipocytes; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Electron Spin Resonance Spectro | 2002 |
Chromium picolinate supplementation improves insulin sensitivity in Goto-Kakizaki diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dietary Supplements; Glucose T | 2004 |
Insulin sensitising action of chromium picolinate in various experimental models of diabetes mellitus.
Topics: 3T3 Cells; Animals; Animals, Newborn; Area Under Curve; Cell Differentiation; Cholesterol; Chromium; | 2004 |
Supplementation with chromium picolinate recovers renal Cr concentration and improves carbohydrate metabolism and renal function in type 2 diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism; Chromium; Creatinine; Diabetes Mellitu | 2005 |
Effect of chromium picolinate on modified forced swimming test in diabetic rats: involvement of serotonergic pathways and potassium channels.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Fe | 2006 |
Hypoglycemic potency of novel trivalent chromium in hyperglycemic insulin-deficient rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Body Weight; Cell Line; C | 2006 |
Antidiabetic copper(II)-picolinate: impact of the first transition metal in the metallopicolinate complexes.
Topics: Adipocytes; Animals; Blood Glucose; Cell Survival; Chemical Phenomena; Chemistry, Physical; Copper; | 2007 |
Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat.
Topics: Animals; Biomarkers; Body Weight; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diet, At | 2007 |
So many choices, so what's a consumer to do?: A commentary on "Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-alpha, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of strepto
Topics: Animals; C-Reactive Protein; Cholesterol; Chromium; Diabetes Mellitus, Experimental; Diabetes Mellit | 2007 |
Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-alpha, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocin-treated diabetic rats.
Topics: Animals; C-Reactive Protein; Cholesterol; Chromium; Diabetes Mellitus, Experimental; Diabetes Mellit | 2007 |
Effect of chronic chromium picolinate in animal models of anxiety and memory.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diabetes Mellitus, Experimental; Disease Mo | 2007 |