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picolinic acid and Aging

picolinic acid has been researched along with Aging in 4 studies

picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206
picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The kynurenine pathway of tryptophan catabolism plays an important role in several biological systems affected by aging."3.77Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. ( Braidy, N; Chan-Ling, T; Grant, R; Guillemin, GJ; Mansour, H, 2011)
"In patients with no apparent CNS disease, CSF PIC levels were 10-fold higher in samples taken between 20:00 and 16:00 h compared with those collected between 04:00 and 12:00 h."1.35Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid. ( Bilgin, A; Coggan, SE; Grant, RS; Smythe, GA, 2009)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Coggan, SE1
Smythe, GA1
Bilgin, A1
Grant, RS1
Braidy, N1
Guillemin, GJ1
Mansour, H1
Chan-Ling, T1
Grant, R1
McCarty, MF2

Other Studies

4 other studies available for picolinic acid and Aging

ArticleYear
Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid.
    Journal of neurochemistry, 2009, Volume: 108, Issue:5

    Topics: Aging; Analysis of Variance; C-Reactive Protein; Case-Control Studies; Central Nervous System Diseas

2009
Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats.
    The FEBS journal, 2011, Volume: 278, Issue:22

    Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectro

2011
Longevity effect of chromium picolinate--'rejuvenation' of hypothalamic function?
    Medical hypotheses, 1994, Volume: 43, Issue:4

    Topics: Aging; Animals; Humans; Hypothalamus; Insulin; Phenformin; Picolinic Acids; Rats; Rejuvenation

1994
Homologous physiological effects of phenformin and chromium picolinate.
    Medical hypotheses, 1993, Volume: 41, Issue:4

    Topics: Adipose Tissue; Aging; Animals; Brain; Humans; Insulin Resistance; Longevity; Neoplasms, Experimenta

1993