picibanil and Spinal-Fractures

We report on the application of OK-432 (picibanil) in a patient with prolonged wound healing impairment. A 13-year-old girl had suffered a polytrauma with a displaced fracture of the sacrum which required neurosurgical decompression of the sacral plexus. Postoperatively, a seroma with recurrent fistulation was seen. Excision of the wound, prolonged suction drainage and the instillation of hypertonic glucose solution did not have any effect over a period of four months postoperatively. Relying on our personal experience of the treatment of lymphangiomas using OK-432 we instilled OK-432 into the wound. Leakage stopped immediately, there was a regression of fluid accumulation and four weeks later the ultrasound examination was normal. The patient is still asymptomatic four years after treatment. OK-432 can be used effectively for the treatment of chronic wound healing impairment.

Topics: Administration, Topical; Adolescent; Antineoplastic Agents; Female; Follow-Up Studies; Humans; Lumbosacral Plexus; Multiple Trauma; Picibanil; Sacrum; Sclerosing Solutions; Spinal Fractures; Surgical Wound Dehiscence; Wound Healing