picibanil and Precancerous-Conditions

The effects of 12 weeks of intravesical instillation of bleomycin, cisplatinum and picibanyl on development of urinary bladder tumors and preneoplastic lesions were examined in rats pretreated with N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for four weeks. Upon sacrifice at week 36, histopathological examination revealed a significantly reduced incidence of PN hyperplasia and a tendency for decreased papilloma generation in rats given cisplatinum. However, the other treatments were not associated with any effect on carcinogen-induced lesion development. The results demonstrate that cisplatinum has a potential for postinitiation inhibition of rat bladder carcinogenesis.

Topics: Administration, Intravesical; Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Products; Bleomycin; Butylhydroxybutylnitrosamine; Cisplatin; Drug Evaluation, Preclinical; Drug Interactions; Epithelium; Female; Nitrosamines; Picibanil; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors; Urinary Bladder; Urinary Bladder Neoplasms