picibanil and Palatal-Neoplasms

We report a very rare case of double cancer involving palatal malignant melanoma and gastrointestinal stromal tumor (GIST), a rare tumor of the gastrointestinal tract originating from a primitive mesenchymal cell. After chemotherapy, radiation therapy, and treatment with interferon and OK-432, the GIST was resected and the melanoma disappeared. The patient has had no evidence of recurrent tumor, and the patient's clinical course has been uneventful for 1 year. This is probably the first report of synchronous double cancer involving oral malignant melanoma and GIST.

Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Gastrointestinal Stromal Tumors; Humans; Interferon-beta; Melanoma; Neoplasms, Multiple Primary; Palatal Neoplasms; Picibanil; Stomach Neoplasms

We used concomitant therapy that consisted of cryosurgery and injection of OK 432 (a hemolytic streptococcal preparation) in the treatment of a giant malignant melanoma that primarily arose from the hard palate to the alveolar process in a 69-year-old man. The tumor consequently disappeared completely. One and a half years later, there are no signs of relapse.

Topics: Aged; Alveolar Process; Biological Products; Cryosurgery; Humans; Male; Melanoma; Palatal Neoplasms; Picibanil